Oleanolic acid Processes Anti-Inflammatory and Anti-Apoptotic Activity in Vivo

By Kyle J. Norton

Inflammation is the natural response of the immune system macrophages, the first line of defense in stimulating the production of inflammatory cytokines to protect our body against the infection caused by foreign microorganisms during the acute phase of body damage and injury.

Truly, the main focus of inflammation is to repair damage and injury.

Most cases of infection associated with inflammation are stopped at the acute phase. The wound or injury is slowly recovered.

Acute inflammation occurs quickly or within the hours and lasts a few days or weeks and the damaged tissues are healed themselves after all pathogens are killed off.

However, if the immune system can not completely eradicate all invaders in the acute phase of infection, it will compromise, leading to chronic low-grade inflammation, a major cause of cardiovascular disease, arthritis, and diabetes.

Chronic inflammation is a low-grade inflammation caused by the inability of the immune system to eliminate the invasive pathogens that occurred in the acute phase of infection.

Any inflammation that lasts more than 8 weeks is considered chronic inflammation.

Believe it or not, worldwide, 3 of 5 death are results from chronic inflammatory diseases like stroke, chronic respiratory diseases, heart disorders, cancer, obesity, and diabetes.

In the US, chronic inflammatory diseases affect more than 50 million Americans each year.

Anti-inflammation is a process that inhibits the pro-inflammatory cytokines without affecting the immune system activity against pathogens.

Diseases associated with low-grade inflammation include diabetes and cardiovascular.

Conventionally, Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most common medical drugs such as aspirin. ibuprofen in reducing inflammation associated with pain-relieving.

Oleanolic acid is a phytochemical in the subclass of Triterpenoid, belonging to the group of Terpenes found abundantly in honey mesquite, garlic, java apple, clove, etc.

On finding a potential plant in the prevention and treatment of chronic diseases, researchers examined the effect of Oleanolic acid (OA), as a triterpenoid, has anti-oxidant, anti-inflammatory, and anti-apoptotic activities on motor function in Spinal cord injury (SCI) mice.

According to the results of the analysis,
* OA in a dose-dependent manner up-regulated the spinal cords of SCI mice and improved blood-spinal cord barrier.

* OA treatments significantly reduced the apoptotic cell death in spinal cord samples of SCI mice by decreasing the expression pro-apoptotic cleaved Caspase-3.

* Furthermore, OA significantly attenuated the pro-inflammatory response in SCI mice.

* Most importantly, SCI mice exhibited higher activation of mitogen-activated protein kinases (MAPKs) and nuclear factor-κB (NF-κB) signaling pathways involved in cell death but these effects were clearly blocked in SCI mice with OA treatments.

In other words, in vivo, OA exerted the protective effects against SCI induced by lipopolysaccharide (LPS)-stimulated mouse neurons mainly through the suppression of apoptosis and inflammatory response.

Taken altogether, Oleanolic acid may be considered a remedy that processes inflammatory and apoptotic activity, pending to the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Oleanolic acid inhibits mouse spinal cord injury through suppressing inflammation and apoptosis via the blockage of p38 and JNK MAPKs by Wang JL1, Ren CH1, Feng J2, Ou CH3, Liu L4. (PubMed)

Healthy Foods Brassica rapa Inhibits the Onset of Acute Liver Injury in Vivo

By Kyle J. Norton

The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing them to other parts of the body.

The liver also produces cholesterol, a waxy substance which aids digestion, builds cell membranes and produces vitamin D and steroid hormones.

Liver disease is a class of medical conditions characterized by the reduction of partly or completely the function of the liver, including liver failure.

Most common types of liver disease in the US are
* Hepatitis C (26%) is a liver disease caused by liver inflammation caused by viral Hepatitis C, leading to irreversible liver scars. Over time, the condition can also induce liver cancer.

* Alcoholic liver disease (21%) is a condition that caused long-term excessive alcohol drinking. It is known that years of alcohol abuse can cause the liver to become inflamed and swollen. Over time, it has been found to induce the formation of liver scars, known as cirrhosis. Cirrhosis is the final stage of liver disease.

* Hepatitis C plus alcoholic liver disease (15%).

* Cryptogenic causes (18%) is a condition with no apparent underlying reason. However, most researchers suggested that many cases of cryptogenic cirrhosis are likely caused by non-alcoholic fatty liver disease (NAFLD), a condition of fat accumulated in the liver.

* Hepatitis B and D (15%) are liver diseases caused by liver inflammation caused by viral Hepatitis C, leading to irreversible liver scars. Over time, the condition can also induce liver cancer.

Human toxicity is a general term refers to any substance which causes harm to human health if inhaled, ingested or absorbed through the skin.

Liver toxicity is a process that causes liver damage by reducing the function of the liver.

Liver oxidative stress caused by a toxic substance such as an overdose of the supplement has been found to constitute most cases of acute liver damage.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

With an aim to find a natural food for the prevention and treatment of liver diseases, researchers examined the hepatoprotective effects of B. Rapa polysaccharides (BRPs) on acute liver injury induced by carbon tetrachloride (CCl4 ) in mice.

According to the results of Mice treated with CCl4 after the oral administration of BRPs (55, 110 and 220 mg/kg) or bifendate (100 mg/kg) for 7 days, 

* BRP pre-treatment significantly decreased the enzymatic activities of liver oxidative stress markers ALT, ALP and AST in the serum, by increasing the activities of antioxidant enzymes SOD and GSH-Px in the liver and reduced the MDA concentration in the liver.

* BRPs alleviated hepatocyte injury and markedly inhibited the expression of pro-inflammatory cytokines TNF-α, IL-1β and IL-6.

* Furthermore, BRPs downregulated the CCl4 -induced hepatic tissue expression of caspase-3 involved in cell apoptosis.

* Moreover, BRPs inhibited the JAK2/STAT3 signaling pathway associated with the inhibition of cell division and stimulation of inflammation in a dose-dependent manner in the liver.

Based on the results, researchers wrote, " BRPs exert hepatoprotective effect against the CCl4 -induced liver injury via modulating the apoptotic and inflammatory responses and downregulating the JAK2/STAT3 signaling pathway"
Taken altogether, Brassica rapa may be considered supplementation for the prevention of acute liver damage, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Brassica rapa Polysaccharides Ameliorate CCl4 -Induced Acute Liver Injury in Mice through Inhibiting Inflammatory Apoptotic Response and Oxidative Stress by Li Q1, Yang H1, Wang W2, Li N1, Zou X1, Li Y2, Fan G1, Zhang Y1,2, Kuang T. (PubMed)

Herbal Elecampane (Inula helenium) Induce the Death of Human Leukemic Cells in Vitro

By Kyle J. Norton


Leukemia is a medical condition arisen from the abnormal white blood cells produced by the bone marrow.

Depending on the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.

Bone marrow, containing two main types of stem cells is the soft tissue inside the hollow center of the major bone, including the spine, pelvis, underarm, leg. etc. with the main function of generating blood cells.

Believe it or not, the bone marrow produces 200 billion new red blood cells every day, to replace the blood cells that die off, along with white blood cells and platelets.

There are several forms of leukemia, including acute lymphocytic leukemia (ALL), acute myelogenous leukemia (AML), chronic lymphocytic leukemia (CLL) and chronic myelogenous leukemia (CML).

CLL and AML are the most common cancers in adults and ALL are most common in children.

In contrast to chronic leukemias that take months or years to develop, acute leukemias start and develop within days or weeks.

According to Leukemia Research, Leukemia causes the death of approximately 68,000 every year. Adults are 10 times more likely to develop the disease, compared to children.

And, Non-Hodgkin's lymphoma is the 7th most common cancer in the U.S. The 5-year survival rate for all subtypes of leukemia is 61.4 percent.

Acute leukemia is a condition caused by a rapid increase in the numbers of extreme immature white blood cells which appear in the bloodstream in the other parts of the body, including tissue and organs,

Chronic leukemia is a condition of the slow but still excessive build-up of relatively mature abnormal white blood cells. The condition has a tendency to spread slowly to other parts of the body through the bloodstream and/or lymphatic system, including chronic lymphocytic leukemia (CLL) and chronic myelogenous leukemia (CML).

On finding a natural ingredient for the prevention and treatment of leukemia, scientists examined Gaillardin (GLN), a sesquiterpene lactone isolated from the chloroform extract of Inula oculus-christi L. on human leukemic cells.

Elecampane, also known as Horse-heal (Inula helenium) is a perennial composite plant, genus nulla, belonging to Asteraceae, native to Southern Europe, and Asia. 

The plant has been used in traditional and herbal medicine in treating bronchitis or emphysema, night sweats, pulmonary tuberculosis, irritating cough, catarrhal discharges, etc.

According to tested analysis,
* GLN could induce cytotoxic effects in human acute T lymphoblastic leukemia (MOLT-4) and B cell precursor leukemia cell line (NALM-6) with IC50 values of 7.3 and 6.1 μM, respectively.

* Furthermore, GLN induces cytotoxicity through G0/G1 phase arrest followed by apoptosis in a dose-dependent manner without affecting the normal cells.

In other words, GLN showed an extend chemotherapeutic sensitivity in ALL cells by reducing VCR concentration without constraining its effectiveness.

Based on the results, researchers suggest, "(Taken together, GLN) it might act as a promising anticancer agent for the treatment of leukemia".

Taken altogether,  Elecampanemay be considered a remedy for the treatment of leukemia, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antiproliferative Effect of Gaillardin from Inula oculus-christi in Human Leukemic Cells by Karami A1, Hamzeloo-Moghadam M2,3, Yami A1, Barzegar M1, Mashati P1, Gharehbaghian A. (PubMed)

Fermented Soy Lowers Blood Cholesterol

By Kyle J. Norton

Cholesterol is a waxy substance that is produced either by the liver or injected from animal food sources.

Cholesterol found in our body is needed for our body to build cell walls, hormones, and vitamin D, and create bile salts that aid digestion. However, too much of them, in most cases due to the intake of animal protein can cause plaques built up on the arterial wall, the major cause of heart disease and stroke.

More precisely, if levels of low-density lipoprotein are high compared to high-density lipoprotein which returns the accessed cholesterol back to the liver, you have high blood cholesterol.

In other words, healthy blood cholesterol is any level with either less than or equal to 4 (low-density lipoprotein/ 1 (high-density lipoprotein).

The most common diseases associated with high cholesterol are cardiovascular disease, including coronary heart disease, stroke, and peripheral vascular disease. 

Most patients with high cholesterol also have diabetes and high blood pressure.

Hyperlipidemia is a condition of abnormally high levels of cholesterol in the bloodstream.

High blood cholesterol is the most common cause of hyperlipidemia. 

According to statistics provided by the CDC, more than 12% of adults age 20 and older are living with high blood cholesterol with a total cholesterol higher than 240 mg/dL. and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL.

In other words, hyperlipidemia has a high prevalent ratio that affects over 100 million Americans and the condition is increasing at an alarming rate due to overweight and obesity.

Believe it or not, only half of the people with high blood cholesterol benefits from taking the lowering blood cholesterol medicine.

Fermented soy products are diverse varieties of soy food that are made from fermented soybeans, including miso, natto, tempeh, and soy sauce.


On finding a potential plant that processes high blood cholesterol activity researchers examined the health benefits of QCAN® Plus-an easily available fermented soy drink.

According to the results of the analysis of the study that was performed in lean (n = 10) and obese (n = 10) subjects during pre-soy (weeks -2, -1, and 0), on-soy (weeks 1, 2, 3, and 4), and post-soy (weeks 6, 8, 10, and 12) periods,

* Total cholesterol and low-density lipoprotein (LDL) cholesterol levels were significantly reduced in both lean and obese individuals during on-soy (P ≤ .05).

* Furthermore, cytokines such as platelet-derived growth factor (PDGF) AA and AB/BB were significantly lowered on-soy compared with pre-soy (P ≤ .05) in lean subjects and PDGF AA, IL-1RA, and GMCSF were significantly reduced on-soy (P ≤ .05) in obese subjects.

* The product is safe.

In other words, QCAN® Plus-an easily available fermented soy drink. showed a strong effect on the inhibition of high blood cholesterol and lipid oxidation.

Collectively, researchers said, "Our preliminary study on Q-CAN Plus ensures its safety for consumption and highlights its hypolipidemic and suppressive effect on certain cytokines ".

Taken altogether, fermented soy may be considered a functional food for the prevention and treatment of high blood cholesterol, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Fermented Soy Beverage Q-CAN Plus Consumption Improves Serum Cholesterol and Cytokines by Arumugam S1, Dioletis E1, Paiva R1, Fields MR2, Weiss TR2, Secor ER3, Ali A, (PubMed)

Healthy Food Cabbage May Prevent Damages Induced by Myocardial Infarction

By Kyle J. Norton

Myocardial infarction is a severe and medical emergency characterized by the obstruction of the blood supply to the brain, causing local brain neurons to death. Prompt treatment can minimize brain damage and potential post disease complications.

In other words, myocardial infarction (MI) occurs due to the imbalance in oxygen supply and demand caused by plaque rupture with thrombus formation in an artery, leading to the reduced blood flow to the heart.

The occurrence and extent of brain infarction are associated with three basic factors, including the site of arterial occlusion, the rapidity of arterial occlusion, and the presence or absence of collateral circulation.

In other words, brain infarction can be classified into myocardial infarction due to plaque rupture and myocardial oxygen supply-demand imbalance secondary to other acute illnesses.

The exact causes of a blood clot to induce acute brain infarction are unknown. Plaques accumulation in the arteries associated with hardening and stiffing arterial walls is a leading cause of cardiovascular disease, including stroke.

According to the statistics provided by the CDC, every year, approximately, about 790,000 Americans have a heart attack, including 580,000 cases of a first heart attack and 210,000 to people who have already had a first heart attack.

The most common symptoms of MI are pressure, tightness, pain, or a squeezing or aching sensation in your chest, digestive discomforts such as nausea, indigestion, heartburn, abdominal pain, shortness of breath and dizziness.

Conventionally, treatment of myocardial infarction is a focus to reduce the damage of the heart muscle accomplished through medical or mechanical means.

Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem with a crowded mass of leaves, usually green but in some varieties, it may be red or purplish.

On findings a natural wholefood for the treatment of post-stroke, researchers examined the effects of anthocyanin-rich red cabbage extract (ARCE) on H2O2 treated rat neonatal cardiomyoblasts (H9c2 cells) and isoproterenol (ISO) induced rodent model of myocardial infarction.

According to the tested analysis,
* H2O2 treated H9c2 cells recorded cytotoxicity (48-50%) and apoptosis (57.3%), compared to the reduction in the presence of ARCE (7-10% & 12.3% respectively).

* Rats pretreated with ARCE for 30 days followed by ISO treatment recorded favorable heart: body weight ratio as compared to ISO treated group.

* Furthermore, the mRNA levels of enzymatic antioxidants (sod and catalase) and apoptotic genes (Bax and BCL-2) in the ARCE+ISO treated group was similar to the control group suggesting that ARCE pretreatment prevents ISO induced depletion of enzymatic antioxidants and apoptosis.

* Moreover, ARCE+ISO treated group (4.5%) recorded results comparable to control (0%) in infracted areas (10%) and derangement of the myocardium.

* ARCE+ISO treated group accounted promote the caveolin-3 associated with the heart muscle and SERCA2a expression involved in the reduce risk of heart failure, compared to the ISO treated group an indication of ARCE in the mediated reduction in membrane damage and calcium imbalance.

Based on the results, researchers wrote, "Overall this study elucidates the mechanism of ARCE mediated prevention of experimentally induced myocardial damage".

Taken altogether, cabbage may be used for the treatment of myocardial infarction, pending to the confirmation of the larger sample size and multicenter human study.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anthocyanin rich extract of Brassica oleracea L. alleviates experimentally induced myocardial infarction by Jana S1, Patel D1,2, Patel S1, Upadhyay K1, Thadani J1, Mandal R3, Das S3, Devkar R. (PubMed)

Omega 3 Fatty Acid Inhibits the Onset of Diabetic Dyslipidemia

By Kyle J. Norton

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

In other words, diabetes occurs when cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

Most common types of diabetes are
* Type 1 diabetes, also known as juvenile diabetes or insulin-dependent diabetes, the most common form diabetes found in children is a condition in which the pancreas does not produce any insulin. The most common form of type 1 diabetes is caused by genetic mutation and some viruses.

* Type 2 diabetes is a medical condition characterized by insufficient insulin entering the bloodstream to regulate the glucose due to either cell in pancreas dying off or receptor sites clogged up by fat and cholesterol.

* Gestational diabetes is a form of diabetes that can occur during pregnancy, affecting between 3% and 20% of pregnant women.
Fat including cholesterol and triglycerides consists of hydrocarbon molecules.

Hyperlipidemia is a medical condition characterized by abnormally high levels of cholesterol in the bloodstream.

Overexpression of cholesterol levels in the bloodstream has been linked to plaques accumulation on the arterial walls, a major cause of some forms of heart disease and stroke.

Untreated high blood cholesterol has been found to induce serious complications including carotid artery disease, coronary heart disease, peripheral artery disease, and stroke.

Diabetic dyslipidemia is a condition associated with low high-density lipoprotein (HDL), increased triglycerides, and postprandial lipemia in diabetics.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of diseases associated with diabetes, researchers examined the effects of ω-3 polyunsaturated fatty acids from different sources on glucolipid metabolism in type 2 diabetic patients with dyslipidemia.

According to the results of the analysis of the participants (n=180) from the diabetes specialist clinic at the Guanlin hospital in Yixing city, Jiangsu Province from February 2017 to March 2017 who were randomly assigned to 3 g/day fish oil (FO), perilla oil (PO), or fish oil mixed with linseed oil (FLO) for 6 months,
* A total of 156 subjects aged (62.6±8.6) years completed the final follow-up after 6 months (FO,54 subjects; PO,52 subjects; FLO,50 subjects).

* Serum glucose, glycated hemoglobin, C peptide, insulin, and homeostasis model assessment-insulin resistance were not significantly different among the three groups after 6 months.

* Serum triglyceride decreased, whereas high-density lipoprotein cholesterol increased in FO [1.33 (1.05,1.93) mmol/L, (1.36±0.29) mmol/L, respectively] compared with PO [1.71 (1.23, 2.17) mmol/L, (1.23±0.22) mmol/L, respectively] and FLO [1.51 (1.12, 2.22) mmol/L, (1.29±0.30) mmol/L, respectively] (P<0.05).

* Serum low-density lipoprotein cholesterol and apolipoprotein B decreased in PO [(2.60±0.57) mmol/L,(0.96±0.23) g/L, respectively] compared with FO [(2.89±0.76) mmol/L, (1.07±0.30) g/L, respectively] (P<0.05).

* Serum lipoprotein(a) decreased in FLO [130.7 (63.3,270.6) mg/L] compared with FO [137.4 (58.7,333.2) mg/L] (P<0.05).

* Serum free fatty acid decreased in FLO [(0.43±0.15) mmol/L] compared with PO [(0.53±0.22) mmol/L] (P<0.05)

Moreover, researchers said, "The effects of ω-3 PUFA from different sources on glucose metabolism in type 2 diabetic patients with dyslipidemia are similar. Each of them has a good application prospect in improving lipid metabolism".

Taken altogether, Omega-3 fatty acids may be considered a remedy for the prevention and treatment of diabetic dyslipidemia, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [Effects of ω-3 polyunsaturated fatty acids from different sources on glucolipid metabolism in type 2 diabetic patients with dyslipidemia].[Article in Chinese; Abstract available in Chinese from the publisher] by Wang F1, Liu HC1, Liu XS2, Dong SN1, Pan D1, Yang LG1, Sun GJ. (PubMed)

Tocopherols Suppress the Onset of Metabolic Syndrome

By Kyle J. Norton

Metabolic syndrome is a group of conditions associated with an increased risk of cardiovascular disease and types 2 diabetes, including high blood pressure, sugar, cholesterol and triglyceride levels and excess body fat around the waist.

Epidemiological studies suggested if you have 3 of the above syndrome, you have metabolic syndrome.

According to statistics, metabolic syndrome is a growing prevalence in the Western world, In the US, 30% of Americans are living with metabolic syndrome,

In other words, 1 in 5 people in Canada has metabolic syndrome, affecting 19.1% of all Canadian adults.

The CDC statistic suggested, among US adults aged 18 years or older, the prevalence of metabolic syndrome rose by more than 35% from 25.3% to 34.2% according to the data from 1988–1994 to 2007–2012.

Symptoms of signs of metabolic syndrome depending on types of affected conditions and complications.

The exact causes of metabolic syndrome are unidentified. However, researchers suggested eating too many calories, particularly in a high-fat diet, physical inactivity, and excessive weight gain are some of the most common and prevalent factors in elevated the risk of metabolic syndrome in the Western world.

Most people with metabolic syndrome do not experience any symptoms until the condition progression into a later stage, overtimes, leading to insulin resistance and plagues built-up on the wall of the arteries.

Tocopherols are phytochemicals of which many have vitamin E activity, belongings to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of chronic diseases, researchers examined the effect of α- and γ-tocopherol levels on metabolic syndrome.

According to the analysis of the magnetic resonance imaging in 641 individuals (mean age 61 years; 40.6% women), 

* The α- tocopherol/cholesterol ratio was positively associated with VAT (β scaled by the interquartile range (IQR): 0.036; 95%Confidence Interval (CI): 0.0003; 0.071) and MetS (Odds Ratio (OR) Odds Ratio (OR): 1.83; 95% CI: 1.21-2.76 for 3rd vs. 1st tertile).


* The γ-tocopherol/cholesterol ratio was positively associated with VAT (β scaled by IQR: 0.066; 95% CI: 0.027; 0.104), SAT (β scaled by IQR: 0.048; 95% CI: 0.010; 0.087) and MetS (OR: 1.87; 95% CI: 1.23-2.84 for 3rd vs. 1st tertile).

* The γ-tocopherol/cholesterol ratio was positively associated with VAT (β scaled by IQR: 0.066; 95% CI: 0.027; 0.104), visceral (VAT) (β scaled by IQR: 0.048; 95% CI: 0.010; 0.087) and MetS (OR: 1.87; 95% CI: 1.23-2.84 for 3rd vs. 1st tertile).

* Finally, α- and γ-tocopherol levels were positively associated with high triglycerides and low high-density lipoprotein cholesterol levels (all Ptrend < 0.05). 

After talking about other factors into account, researchers said, "Circulating vitamin E levels displayed strong associations with VAT and MetS".

Taken altogether, tocopherols used regularly may be considered adjunct therapies for the prevention and treatment of metabolic syndrome, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Association of Vitamin E Levels with Metabolic Syndrome, and MRI-Derived Body Fat Volumes and Liver Fat Content by Waniek S1, di Giuseppe R2, Plachta-Danielzik S3, Ratjen I4, Jacobs G5,6, Koch M7,8, Borggrefe J9, Both M10, Müller HP11, Kassubek J12, Nöthlings U13, Esatbeyoglu T14, Schlesinger S15, Rimbach G16, Lieb W. (PubMed)