Herbal Ashwagandha inhibits the Pre-Cancer Stage of Multiple Myeloma in Vitro

By Kyle J. Norton

Cancer is a group of diseases characterized by the irregular cell growth on the body tissue, due to the alternation of cell DNA.

Most cases of cancer start in the cell on the surface of the inner lining tissue and do not exert any symptoms at the early stage.

At the later stage, the larger size tumor may press on the nearby blood vessels and nerve cells, causing localized severe bleeding and pain accompanied by the general symptoms of cancers, including the unintended weight loss, loss of appetite, fatigue and tiredness and gastrointestinal problems.

Most cancer cells at this stage can also travel a distance away from the original site to affect other healthy tissue and organs, leading to secondary metastasis.

Pre-cancer is a medical condition that likely develops into cancer if untreated.

Monoclonal gammopathy of undetermined significance (MGUS) is a precancerous condition and the most common plasma cell disorder.

In other words, monoclonal myeloma gammopathies is a precancerous condition that may cause myeloma, a cancer of white blood cell disorder.

Multiple myelomas. also known as plasma cell myeloma or Kahler's disease, is a type of abnormal growth of plasma cells collected in the none marrow where they grow and multiply to interfere with the production of normal blood cells. 

According to the study by the Harvard Medical School, paraprotein, an abnormal antibody produced by the plasma cell myeloma not only can cause kidney problem but also interference with the Roche automated total bilirubin, including total bilirubin (TBIL), direct bilirubin (DBIL), or HDL-cholesterol (HDL-C).

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound that processes the anti-cancer property, researchers examined the effects of Withaferin A (WA) isolated from the plant Withania somnifera, antitumor effects on a multiple myeloma cell model.
According to the results from Ingenuity Pathway Analysis and Western blot, WA exerted a significant action against monoclonal gammopathy of undetermined significance (MGUS) and related disorders.

Furthermore, WA showed a strong and massive blockage on both proteotoxic and oxidative stress response pathways by targeting protein networks such as multicatalytic proteinase complex, associated with the risk of monoclonal gammopathy.

In other words, WA mediated apoptosis is preceded by simultaneous targeting of cellular stress response pathways like proteasome degradation, autophagy and unfolded protein stress response.

Based on the findings, researchers said, "the combined approach can be used for other types of cancer and/or other promising multifunctional compounds, thereby increasing the potential development of new antitumor therapies".

Taken altogether, Ashwagandhaprocessed abundantly WA may be considered a functional herb for the modulation of the monoclonal myeloma gammopathies, pending to the result of larger sample size and multicenter study

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Proteomic characterization of Withaferin A-targeted protein networks for the treatment of monoclonal myeloma gammopathies by Dom M1, Offner F2, Vanden Berghe W1, Van Ostade X. (PubMed)
(2) Multiple Myeloma by Kyle J. Norton

Herbal Angelica Processes Neuro-Protective Activity

By Kyle J. Norton

Neuroprotection is a process to preserve the neuronal structure and/or function against the death or gradual death of neurons, including the use of medicines and herbs.

In other words, neuroprotection protects the neuronal integrity against the reduction in the rate of neuronal loss over time inducing neurological disease, including neurodegenerative disease.

Brain ischemia is a condition caused by insufficient blood flow to the brain to meet metabolic demand, leading to irreversible brain damage in severe cases.

In other words, brain ischemia-induced the death of neurons of the affected tissues.

Brain ischemia can be classified into
* Focal ischemia is a condition caused by damage to a specific region of the brain; and

* Global ischemia is a condition of damage that affects the wide areas of brain tissue, leading to symptoms of impairments in vision, body movement, and speaking.

Dr. Jin-Moo Lee in the study of the issues of how the brain tissue responses to ischemia, said, "The brain is particularly vulnerable to ischemia. Complete interruption of blood flow to the brain for only 5 minutes triggers the death of vulnerable neurons in several brain regions, whereas 20–40 minutes of ischemia is required to kill cardiac myocytes or kidney cells".

And, "...the brain’s intrinsic cell-cell and intracellular signaling mechanisms, normally responsible for information processing, become harmful under ischemic conditions, hastening energy failure and enhancing the final pathways underlying ischemic cell death in all tissues, including free radical production, activation of catabolic enzymes, membrane failure, apoptosis, and inflammation".

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a potential compound for the protection of the brain, researchers examined the neuroprotective effects of Xixian Tongshuan Preparation containing Ligusticum chuanxiong, Angelica Sinensis, Carthamus tinctorius, and Panax pseudo-ginseng.

According to chemical analysis, all constituents found in the formula work synergistically to protect the neurons against damage.

Furthermore, the formula inhibited the 5 glutamate receptors, TGFR-1, and VEGFR-2 in the mediation of the production of pro-inflammatory cytokines to induce neuron death and injury.

Moreover, a single component, such as neo-complanatoside and neo-carthamin, in Xixian Tongshuan Preparation could simultaneously act on different targets to exert their neuroprotective effects.

Based on the findings, researchers wrote, "This study explains the multi-target mechanism of anti-cerebral ischemic injury in neuroprotection at the molecular level, and provides a certain direction for the clinical application and experimental research of Xixian Tongshuan Preparation".

Taken altogether, herbal Angelica in combination with other herbal medicines that may be considered a neuroprotective remedy, pending to larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal  - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 
,
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [Multi-target neuroprotective effect of Xixian Tongshuan Preparation against cerebral ischemia injury].[Article in Chinese] by Gu Y1, Zhao BW1, Chen X1, Luo YZ1, Zhang YL. (PubMed)
(2) Brain tissue responses to ischemia by Jin-Moo Lee, Margaret C. Grabb, Gregory J. Zipfel, and Dennis W. Choi. (PMC)

Herbal Dandelion (Taraxacum officinale) Inhibits the Progression of Rheumatoid Arthritis (RA)

By Kyle J. Norton


Arthritis, one of the Musculoskeletal disorders (MSDs) degenerative disease, is a general term of joint inflammation, affecting over 21% of the US population.

There are over 100 different forms of arthritis and related diseases. Rheumatoid arthritis (RA), is the common form of arthritis involved in chronic low-grade inflammation.

Juvenile arthritis is an inflammatory disease affecting the synovium in children aged 16 or younger.

In other words, it is an autoimmune disorder caused by the immune system attacks some of the body's own healthy cells and tissues, in this case, the immune system attacks the joint tissue in the juvenile.

Genes that are associated with the risk of juvenile idiopathic arthritis include HLA-A. HLA-B. HLA-DPB1. HLA-DQA1. HLA-DQB1. HLA-DRB1. IL2RA. IL6, according to the National Institute of Health.

According to the statistic, the most common form of juvenile idiopathic arthritis (JIA), affects over 50,000 children in the United States alone.

Rheumatoid Arthritis (RA) is a type of arthritis associated with inflammation that affects mostly the flexible (synovial) joints and tissues and organs in the body.

The disease affects more women than men and generally occurs after the ages of 40, causing the diminished quality of life of many older adults.

According to the CDC, musculoskeletal disorders (MSDs) affect over 52 million adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions.

Rheumatoid Arthritis can induce bone loss through elevating bone resorption without increasing bone formation.

A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes.


Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the treatment of chronic inflammatory diseases, scientists examined taraxasterol (TAR), a bioactive active compound pentacyclic triterpenes isolated from Chinese medicine herb Taraxacum officinale effects on rheumatoid arthritis (RA). 

In Vitro and Vivo, the application of TRA significantly suppressed the proteins involved in the production of pro-inflammatory cytokines, namely tumor necrosis factor-α (TNF-α), IL-6, and IL-8 by blocking NOD-like receptor protein 3 (NLRP3) inflammasomes, activators of IL-1β secretion, particularly in the joints tissues of collagen-induced arthritis (CIA) mice.

Furthermore, the application of TRA also inhibited the enzymes involved in the productions of matrix metalloproteinases (MMPs), like MMP-1 and MMP-3 in HFLS-RA in vitro, degradation of the normal tissues.

Moreover, the injection of TRA also blocked nuclear factor kappa B (NF-κB) activation via modulating inhibitors of kappa B (IκB), IκB kinase (IKK) in the control of cytokines production and cell survival and transforming growth factor-β-activated kinase 1 (TAK1) to prevent the accumulation of ROS, resulting in cell death and inflammation.

Taken altogether, dandelion may be considered a remedy for the treatment of rheumatoid arthritis, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Taraxasterol suppresses inflammation in IL-1β-induced rheumatoid arthritisfibroblast-like synoviocytes and rheumatoid arthritis progression in mice by Chen J1, Wu W2, Zhang M1, Chen C. (PubMed)

Herbal Angelica Modulates the Immune Response In Vivo

By Kyle J. Norton

Immunomodulators are agents that have unique functions to modify the immune response or the functioning of the immune system such as the stimulation of antibody formation or the inhibition of abnormal white blood cell activity.

In other words, immunomodulation processed immunotherapy, in which immune responses are induced depending to the body needs.

The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases.

The immune system does a great job of keeping people healthy and preventing infections.

Besides foods and nutritional supplements, herbs also play important roles in helping the immune system to defend against viruses and bacteria attacks.

A variety of factors have been found to trigger immune responses include pathogens, damaged cells, and toxic compounds.

The immune response is a natural reaction of the immune system to protect our body against the invasion of foreign substances.

Inflammation is a natural response of the immune system which protects the body against the invasion of pathogens.

In the acute phase of infection, the immune system initiated the production of proinflammatory Th1 cytokines in activated interleukin-12 (IL-12) and gamma interferon (IFN-γ) and other pro-inflammatory factors such as TNF beta in response to detect, engulf and destroy pathogens and apoptotic cells through macrophages.

These activities played an important in induced apoptosis and reduced proliferation of bacteria or viruses by attaching to the surface of the injured cells to initiation of an alternation. however, overproduction of pro-inflammatory expression may indeed cause substantial adverse effects in tissue destruction, and, in some cases, shock and death.

Type 1 T helper (Th1) in response to tissue damage and injure also activated macrophages that are responsible for cell-mediated immunity and phagocyte-dependent protective activity.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a potential compound for the modulation of the immune functioning, researchers examined the effects of Dangguibuxue Tang (DBT), including herbal angelica on the growth performance and immune response in immunosuppressed broiler chicks.

A total of 240 one-d-old broiler chicks (DaHeng S01)with 4 d to r7 d of age, in the study were randomly divided into 4 groups, 2.0% DBT-treatment (A), 0.5% DBT-treatment (B), cyclophosphamide-control (C), and control group (D) from 8 d to 42 d of age, after the tested chicks in groups A, B and C were also given cyclophosphamide (CY) at a dosage of 100mg/kg body weight (BW) daily by intraperitoneal injection to induce immunosuppression.

Furthermore, the Chicks in the control group D were given an equal volume of physiological saline daily by intraperitoneal injection.

The experimental results suggested that compared to cyclophosphamide-control (C), chicks from group B has a lower feed gain rate (FGR), lower total mortality, higher immunity organ indexes.

Additionally, also compared to group C, chick in group B also demonstrated a significantly higher antiviral and infectious (Newcastle disease (ND) and infectious bursal disease (IBD)) antibody.

Moreover, the levels of pro-inflammatory cytokines induced by higher levels of interleukin-2 and interleukin-6 levels, and the response of greater lymphocyte proliferative responses to concanavalin A (ConAin) in the group B were also significantly lower compared to the group C.

In other words, Dangguibuxue Tang (DBT) displays strongly immune-modulatory effects regardless of the dose of herbal decode.

Based on the results, researchers said, "These results indicate that supplementation of 0.5% of DBT can improve both cellular immunity and humoral immunity in immunosuppressed broiler chicks".

Taken altogether, Herbal Angelica used alone or in the combination with other herbal medicines may be considered a function for improving immune response, pending to larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of Dangguibuxue Tang, a Chinese herbal medicine, on growth performance and immune responses in broiler chicks by Li XT1, Wang B, Li JL, Yang R, Li SC, Zhang M, Huang W, Cao L. (PubMed)

Lycopene Protects the Cells of Large Intestine Against colitis

By Kyle J. Norton

Colitis is medical a condition characterized by the inflammation of the large intestine, including the colon, caecum, and rectum.

Depending on the causes, colitis can be classified into microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis, and Behcet's colitis, particularly in those associated with inflammatory bowel disease (IBD), such as ulcerative colitis (UC).
* Inflammatory bowel disease (IBD) is the inflammation of chronic inflammation of the digestive tract associated with symptoms of severe diarrhea, abdominal pain, fatigue, and weight loss.

* Microscopic colitis is a disease involved in the inflammation of the colon or large intestine, associated with symptoms of watery diarrhea and cramping. Microscopic colitis is much less severe than other types of inflammatory bowel disease.

* Ischemic colitis is an inflammation of the large intestine caused by the injury-induced inadequate blood supply to the colon, leading to pain on the left side of the abdomen.

* Segmental colitis associated with diverticula is an inflammation that affects colonic luminal mucosa in segments due to diverticulosis, causing symptoms of bloody stools, sometimes accompanied by abdominal pain, cramping discomfort, or diarrhea.

* Radiation colitis is an inflammation of the large intestines in patients with radiation therapy, leading to symptoms of diarrhea, nausea, vomiting and stomach cramps.

* Diversion colitis is an inflammation of the large intestines as a complication of ileostomy or colostomy. Most cases of diversion colitis often occur within the year following the surgery.

* Eosinophilic colitis is a rare disease associated with a type of white blood cell, due to injury and inflammation to the large intestine.

* Behcet's colitis is chronic immune-mediated, inflammatory disorders that only affect the intestines but also the joints, skin, eyes, and biliary tracts.

Conventionally, colitis caused by infection is treated by antibiotics. However, treatment of non-infection colitis is focusing on symptoms relief, supportive care, and maintaining adequate hydration and pain control.

Most common tools used for the colitis diagnosis are X-rays of the colon, testing the stool for blood and pus, sigmoidoscopy and colonoscopy.

Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

On finding a potential compound for the treatment of inflammatory bowel disease (IBD), researchers examined the role of lycopene in a rat model of colitis induced by acetic acid.

Selected rats included in the study were randomly divided into the following five groups: the control group, colitis group, colitis + sulfasalazine group as a positive control group, colitis + lycopene and lycopene groups.

According to the chemical analysis, malondialdehyde (MDA) associated with stress marker, total sialic acid and DNA fragmentation levels associated with inflammatory expression were significantly higher in the colitis group.

Furthermore, the levels of antioxidant enzymes in the colitis group were lower comapred to the control group.

However, treatments with lycopene in the colitis group not only decreased MDA, total sialic acid and DNA fragmentation levels but also increased the levels of superoxide dismutase (SOD), total antioxidant status (TAS), and CPN, the body's inbuilt defensive mechanism against noxious responses or inflammation.

Moreover, Fe deficiency found in 1/3 patients with IBD were also increased significantly by the lycopene injection.

Based on the findings, researchers said, "Treatment with lycopene ameliorated the biochemical and pathological alterations caused by colitis.".

Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of colitis, pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You.  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Lycopene Ameliorates Experimental Colitis in Rats via Reducing Apoptosis and Oxidative Stress by Gul Baykalir B1, Aksit D1,2, Dogru MS3, Hanım Yay A4, Aksit H1,2, Seyrek K5, Attesahin A. (PubMed)

Turmeric's Curcumin Gel, the Natural Prevention and Treatment of Acne

By Kyle J. Norton

Acne or acne vulgaris is a chronic skin disease associated with the inflammation caused by hair follicles clogged up by dead skin cells and oil from the skin.

Holistically, acne can also be caused by the system of toxins in the body due to the liver and kidney inability to cleanse all toxins in the body, leading to toxin accumulated on the skin in facilitating the acne forming.

According to  experts, there are many things you can do to prevent acne from developing, including 

* Acne care with cream and lotion
Be sure before applying skin cream or lotion in acne affected area, wash it with mild soap and tepid water because water too hot or too cold might cause the breaking of capillaries (small veins). 

The best choice of acne cream and lotion is the one made by using ingredients of natural remedies that exist in the kitchen of your home for cost-effectiveness and little or no side effects.

* Following a healthy diet with reduced intake of saturated fat
Saturated fat intake causing the build-up of cholesterol in capillaries, the small veins in your skin, leading to oily skin and skin that is easy to attract dirt. 

It is recommended that you should substitute your red meat intake by 4- 8 servings every week with fish to prevent cholesterol build-up in small veins in the skin.

* Lower your body toxins by adding some delicious antioxidants super-foods in your diet will help to solve this problem quickly such as garlic, ginger, etc.

Conventionally, acnes are treated with antibiotics, with an aim to control the acne and avoid scarring or damage to the skin. If you are currently using antibiotics for acne treatment, please make sure you know all the side effects for preventive measures.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a potential compound for the treatment of acne with no side effects, researchers compared the effect of encapsulating curcumin, with size and zeta potential of ∼100 nm and ∼14 mV to those of azithromycin.

According to the agar diffusion assay, encapsulating curcumin showed a significant antibacterial activity through the lauric acid gel formulation by∼1.5 fold improvement compared to curcumin gel formulation. 

The combined application of encapsulating curcumin plus azithromycin exhibited significantly enhanced antibacterial effect against both macrolide-sensitive (1.81 versus 1.25 folds) and resistant strains of P. acnes (2.93 versus 1.22 folds) compared to individual counterparts.

In vivo, rat ear model induced acne, encapsulating curcumin, displayed a ∼2 fold reduction in comedones count and production of inflammatory cytokines, compared to the placebo-treated group.

In order to obtain more information about curcumin anti ance activity, researchers investigated, the visible blue light (BL, λmax = 462 nm) enhanced the antimicrobial activities of curcumin, a natural phenolic compound.

According to the tested assays, curcumin at 0.09 J/cm2 BL with 1.52 μM showed a significant decrease in the viability of Propionibacterium acnes (P. acnes).

The low-dose blue light irradiation also improved the function of curcumin cytotoxic effect against the progression of P. acnes. 

Furthermore, curcumin induced membrane disruption of microbes against P. acnes.

Based on the findings, researchers wrote, " Because the safety of blue light in the mammalian cell has been proven, the photolytic curcumin treatment could support non-antibiotic therapy to eradicate P. acnes on clinical dermatology".

Taken altogether, encapsulating curcumin or the visible blue light (BL, λmax = 462 nm) enhanced the antimicrobial activities of curcumin may be considered supplements for the prevention and treatment of acne, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Design, preparation, and evaluation of liposomal gel formulations for treatment of acne: in vitro and in vivo studies by Madan S1, Nehate C1, Barman TK1, Rathore AS2, Koul V. (PubMed)
(2) Low-dose blue light irradiation enhances the antimicrobial activities of curcumin against Propionibacterium acnes by Yang MY1, Chang KC2, Chen LY3, Hu A. (PubMed)

Phytochemical indicaxanthin in the Prevention and Treatment of Intestinal Motility Disorders

By Kyle J. Norton

The digestive system included the gastrointestinal tract, the liver, pancreas, and gallbladder play a critical role to maintain the body normal function by providing nutrients and fluids to the body and remove waste through the secretary system.

Digestion is a process of the digestive system by breaking out down food after food intake through mechanical and enzymatic action.

Indigestion, on the other hand, is symptoms of another digestive disease, including GERD. Most cases of indigestion not caused by underlying diseases can be resolved quickly.

People with indigestion experience symptoms differently. Some may feel the symptoms of occasionally while others may feel often and daily.

The intestines, including the small, large and anus are a long tube that runs from the stomach to the anus.

The small intestines play a critical role to absorb nutrients and minerals from foods. 90% of the digestion and absorption of food occurs in the small digestion.
The large intestines help the body to the recovery water and electrolytes, formation and storage of feces and fermentation of some indigestible food matter by bacteria.

The anus is a last potion of the intestine that stores and eliminates feces.

Intestinal contractility is a process or action of smooth muscle in the intestinal wall that produces tonic contractions for the effective digestion and uptake of nutrients.

In other words, GI motility, secretion, regulation, digestion, and circulation formed a complete chain for maintaining good health

Betaxanthins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, Sicilian prickly pear, etc.

On finding a potent ingredient for the improvement of the digestive absorption, researchers examined the indicaxanthin, a chemical constituent of betaxanthins, spasmolytic effects on the intestinal contractility.

In vitro, according to the results of record the mechanical activity, indicaxanthin induced inhibitory effects on spontaneous mechanical activity, without affecting the anti-inflammatory activity of indomethacin, a non-selective inhibitor of cyclooxygenase.

Furthermore, the presence of 3-isobutyl-1-methylxanthine (IBMX), a nonselective inhibitor of phosphodiesterases (PDEs) was found to reduce the indicaxanthin effects in intestinal contractility.

Injection of the combination of Indicaxanthin and IBMX significantly reduced the carbachol-evoked contractions without producing any additive effect. 

The combined indicaxanthin and IBMX exerted an increased inhibitory effects of forskolin, an adenylyl cyclase activator, without additive effect.

Moreover, the chemical compound showed no effect on sodium nitroprusside, a soluble guanylyl cyclase activator.

Indicaxanthin increased both basal and forskolin-induced cAMP content of mouse ileal muscle, a second messenger for intracellular signal transduction to regulate glycogen, sugar, and lipid metabolism.

Based on the findings, researchers said, "Indicaxanthin reduces the contractility of ileal longitudinal muscle by inhibition of PDEs and increase of cAMP concentration and raises the possibility of using indicaxanthin in the treatment of motility disorders, such as abdominal cramps".

Taken altogether, Indicaxanthin may be considered a functional remedy for the treatment of digestive motility dysfunction, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibitory effects of indicaxanthin on mouse ileal contractility: analysis of the mechanism of action by Baldassano S1, Rotondo A, Serio R, Livrea MA, Tesoriere L, Mulè F. (PubMed)