Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Monday, 2 September 2019

Mustards in the Prevention and the Treatment of Chronic Diseases

By Kyle J. Norton

Chronic diseases are a group of medical conditions most commonly associated with aging, including
arthritis, cardiovascular diseases such as heart attacks and stroke, cancer, diabetes, epilepsy and seizures, and obesity.

Nutrigenomic activity is a scientific term that optimizes the interaction of nutrition and genes, especially in the prevention or treatment of disease.

In other words, the nutrigenomic activity provided information on how the interaction of certain foods with specific genes that lead to the increased risk of chronic diseases such as type 2 diabetes, obesity, heart disease, stroke, and certain cancers.

Biologically, nutrigenomics also provided the information molecularly how chemicals found in the diet altered the expression of genes that affect the individual health.

More precisely, nutrigenomics is depending totally on an individual's genetic makeup.

According to the Centers for Disease Control, chronic diseases also are the major driver of health care costs, accounting for nearly 75 percent of aggregate healthcare spending and increasing absenteeism that impact workforce patterns.

Each chronic patient has cost the health care spending $5300 annually.

Believe it or not, chronic diseases in the US, chronic diseases are responsible for 7 out of 10 deaths yearly. In other words, chronic diseases kill more than 1.7 million Americans each year.

According to the joint study led by the Fordham University, chronic diseases are among the most prevalent and costly health conditions in the US, affecting over 133 millions of the US population as many of them suffer from at least one chronic disease and the number is growing in the rapid rate.

Some chronic diseases such as cancer have been found to be the leading causes of hospitalization, long-term disability, reduced quality of life, and death.

The World Health Organization suggested that unhealthy diet and excessive energy intake, physical inactivity, and tobacco use are some of the most common cause of chronic diseases.

In other words, an unhealthy diet and physical inactivity raised blood pressure, raised glucose levels, abnormal blood lipids (particularly low-density lipoprotein – LDL cholesterol), and overweight (body mass index ≥25 kg/m2) and obesity (body mass index ≥30 kg/m2) are some of the most common prevalent factors found in patients in the Western World.

Other risk factors associated with the risk of chronic disease also inclduing excessive alcohol drinking, infectious agents, some environmental factors such as air pollution, which contribute to asthma and other chronic respiratory diseases.

Some researchers suggested by changing unhealthy lifestyle pattern, chronic diseases may be preventable.

Dr. Walter C. Willett, the lead scientist in the concern about the risk chronic disease in poor lifestyle individuals wrote, "Several lines of evidence indicate that realistic modifications of diet and lifestyle can prevent most CAD, stroke, diabetes, colon cancer, and smoking-related cancers".

And, "Among U.S. adults, more than 90 percent of type 2 diabetes, 80 percent of CAD, 70 percent of stroke, and 70 percent of colon cancer are potentially preventable by a combination of nonsmoking, avoidance of overweight, moderate physical activity, healthy diet, and moderate alcohol consumption".

Mustard is a genus Brassica, belongings to the family Brassicaceae, native to the Himalayan region of India. The veggie has seen used in some forms in African, Italian, Indian, Chinese, Japanese, and soul food cuisine because of its popularity.
With an aim to find natural food that lowers the incidence of chronic diseases including different kinds of cancer, researchers examined the anti-cancer effects of sulfur-containing glucosinolates (GLSs)-secondary plant compounds from mustards, including isothiocyanates.

According to medical literature, ITCs promoted overall health in vitro and vivo. The phytochemical also exerted anti-carcinogenic and anti-inflammatory properties by activating the redox-sensitive transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) involved in antioxidants expression. and phase II enzymes involved in drug metabolism.

Furthermore, administration ITCs also significantly ameliorate a severe inflammatory phenotype in colitic mice in vivo.

In other words, ITCs inhibited the risk of chronic disease through its antioxidants and anti-chemical toxicity activity.

Researchers after taking other factors into account wrote, "an epigenetic mode of action for Brassica-derived phytochemicals, the conduction of further studies would be recommendable to investigate if the beneficial effects of these compounds also persist during an irregular consumption pattern".

Taken altogether, mustards processed abundantly ITCs may be considered supplements for the prevention and treatment of chronic diseases, pending to the confirmation of the larger sample size and multicenter human study.

Intake of SFN in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Brassica-Derived Plant Bioactives as Modulators of Chemopreventive and Inflammatory Signaling Pathways by Sturm C1, Wagner AE. (PubMed)
(2) Chronic diseases and health promotion by WHO
(3) Chapter 44Prevention of Chronic Disease by Means of Diet and Lifestyle Changes by Walter C. Willett, Jeffrey P. Koplan, Rachel Nugent, Courtenay Dusenbury, Pekka Puska, and Thomas A. Gaziano. (NCBI)

Phytochemicals Betaxanthins Reduce the Risk of Stenosis of the Arteries

By Kyle J. Norton

Stenosis of the arteries is a narrowing large artery caused by the accumulation of plaques located on each side of the neck that carries blood to the head, face, and brain.

Most common causes of stenosis of the arteries are results from atherosclerosis.

Untreated stenosis of the arteries has been found to induce complications of transient ischemic attack or stroke, depending on a blot clot that briefly blockage or partly or completely blockage of a blood vessel to the brain.

Atherosclerosis is a medical condition caused by plaque accumulated on the wall of arteries, leading to the narrowing of the artery and reducing oxygen risk blood flow to the heart and brain.

Depending on the location of the blockage, if the reduced blood flow occurred in the brain, it will cause the death of the brain cells, leading to stroke.

However, if the reduced blood flow occurred in the heart, it will cause damage to the heart tissues, leading to heart disease.

Most common disease associated with atherosclerosis is coronary artery disease. Plaques are made up of cholesterol, calcium and other chemical substances in the artery

Most people with atherosclerosis are asymptomatic at the early stage.

Some researchers suggested that atherosclerosis is a lipoprotein-driven disease. Therefore, people with high blood cholesterol are at an increased risk of atherosclerosis. Overuse of calcium supplement is also found to elevated the condition risk, particularly in the elderly.

Other risk factors that have bee found epidemiologically by studies are high blood pressure, triglycerides, smoking, insulin resistance, obesity or diabetes and inflammatory diseases, such as arthritis, lupus or infections.

Most cases of atherosclerosis can be reversed by making a change of lifestyle and moderate exercise. However, in severe cases surgery to remove plaque from the artery may be the only option.

Betaxanthins are Phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, Sicilian prickly pear, etc.

On finding a potent ingredient for the treatment of cardiovascular disease, researchers investigated the effects of betalains, consisting of betacyanins and betaxanthins on the stenosis of the arteries.

In vivo and in vitro studies, betalains and betalain-rich diets is not only safe but also inhibited oxidative stress-, inflammation-, and dyslipidemia-related diseases associated with narrowing arteries involved in atherosclerosis, or a build-up of plaque on the inside of the arteries.

Furthermore, betalains and betalain-rich diets are safe toxicological safety, incorporated with easy accessibility, low price, biodegradability, and potentially advantageous biological effects on health.

These results strongly suggested betalains may be used in food manufacturing and related industries to overcome current concerns over the health risks of artificial colors.

Dr. Rahimi P, the lead scientist wrote, "(Even with the efficacy), further studies using pure betalains are required to gain a deeper understanding of their precise biological functions".

Taken altogether, betaxanthins found abundantly in betalains and betalain-rich diets may be considered anti-atherosclerotic remedy, pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) Betalains, the nature-inspired pigments, in health and diseases by Rahimi P1, Abedimanesh S1, Mesbah-Namin SA1, Ostadrahimi A. (PubMed)

Western diet Is Associated with The Risk of Metabolic Syndrome

By Kyle J. Norton

The Western pattern diet or typical American diet is a modern dietary pattern associated with a high intake of processed foods, red meat, processed meat, fried and refined foods, and high-sugar.

The Western pattern diet has also been found to induce chronic diseases. Dr. Hariharan D, the lead scientist wrote, "Characteristics of the Western diet that fueled the obesity epidemic may also impact kidney disease incidence and progression. Enlarging portion sizes over the past half-century have been accompanied by increased intake of protein, sodium, and processed foods while consumption of fruits and vegetables has declined".

And, ", the Western diet, characterized by high intake of red meat, animal fat, sweets, and desserts and low intake of fresh fruits and vegetables and low-fat dairy products, increases risk of chronic diseases".

The results clearly suggested, if you are following a traditional diet with high fruits and vegetable and fewer in processed food, saturated and trans fat, and red meat accompanied with moderate exercise daily, you are at a substantially decreased risk of chronic disease, compared to those who follow the Western diet.

Metabolic syndrome is a cluster of conditions that increase the risk of cardiovascular disease and diabetes, including too much fat around the waist, high blood pressure, triglycerides, and blood sugar, and low HDL cholesterol.

In other words, if you process 3 of the aforementioned conditions, you are at a higher risk of heart disease, stroke, and diabetes. However, most people with metabolic syndrome have never developed
CVD and diabetes.

Other than high blood glucose, most patients with metabolic conditions are asymptomatic.

Epidemiologically, aging, ethnicity, obesity, medical condition such as diabetes, nonalcoholic fatty liver disease, and polycystic ovary syndrome are most risk factors found in patients with the syndrome.

Green peas are species of Pisum Sativum belongings to the family Fabaceae and native to western Asia from the Mediterranean Sea to the Himalaya Mountains. The pea is a green, pod-shaped vegetable and a cool-season crop grown in many parts of the world.

On finding a potent ingredient for the reduced risk of cardiovascular disease and diabetes, researchers investigated the association between major dietary patterns and prevalence of the metabolic syndrome in individuals with impaired glucose tolerance.

The cross-sectional study included a total of 425 subjects 35 to 55 y of age. According to the returned food-frequency questionnaire from participants,

* The Western pattern with a high in sweets, butter, soda, mayonnaise, sugar, cookies, tail of a lamb, hydrogenated fat, and eggs was associated with greater odds of having increased triacylglycerol (odds ratio 1.76, 95% confidence interval 1.01-3.07) and blood pressure (odds ratio 2.62, 95% confidence interval 1.32-5.23).

* The prudent pattern with a high in fish, peas, honey, nuts, juice, dry fruits, vegetable oil, liver and organic meat, and coconuts and low in hydrogenated fat and non-leafy vegetables was associated with a prevalence of low high-density lipoprotein cholesterol levels (odds ratio 0.55, 95% confidence interval 0.31-0.96).

* The vegetarian dietary pattern with a was inversely associated with a risk of an abnormal fasting blood glucose level (odds ratio 2.26, 95% confidence interval 1.25-4.06).

Based on the findings, researchers said, "Major dietary patterns were significantly associated with the risk of metabolic syndrome".

Taken altogether, People who follow the Western diet are at a higher risk of cardiovascular disease and diabetes comapred to other dietary patterns.

Sources
(1) Relationship between major dietary patterns and metabolic syndrome among individuals with impaired glucose tolerance by Amini M1, Esmaillzadeh A, Shafaeizadeh S, Behrooz J, Zare M. (PubMed)
(2) The Western Diet and Chronic Kidney Disease by Hariharan D1, Vellanki K, Kramer H. (PubMed)

Green Peas (Pisum Sativum) Reduces the Risk of Inflammatory Bowel Disease

By Kyle J. Norton

An inflammatory bowel (IBD) disease is a group of chronic inflammatory diseases associated with the gastrointestinal tract, including ulcerative colitis and Crohn's disease.

Ulcerative colitis has been found to induce chronic inflammation and ulcers in the inner lining of the large intestine (colon) and rectum, causing diarrhea, often with blood or pus, abdominal pain, and cramping, rectal pain, and bleeding and urgency to defecate.

Crohn's disease is a type of IBD associated with the inflammation of the lining of the digestive tract, leading to symptoms of frequent, recurring diarrhea, rectal bleeding, unexplained weight loss, fever.
and abdominal pain and cramping.

According to the statistics, provided by the CDC in the US, IBD affects over 1.3% or 3 million US adults including Crohn's disease or ulcerative colitis in 2015.

Most common symptoms of IBD include diarrhea, fever, and fatigue, abdominal pain and cramping, loss of appetite and unintended weight loss and blood in the stool.

Conventionally, most cases of IBD are treated with anti-inflammatory medicine, immune suppressor or antibiotics, and drugs that reduce symptoms, depending on the severity of the conditions.

Most cases of IBD has been found in older adults in the age of 45 years or older.

Dr. Danielle Nimmons and Jimmy K Limdi said, "The incidence and prevalence of inflammatory bowel disease (IBD) are increasing globally. Coupled with an aging population, the number of older patients with IBD is set to increase. The clinical features and therapeutic options in young and elderly patients are comparable but there are some significant differences".

And, "In addition, age-specific concerns such as co-morbidity; loco-motor and cognitive function, poly-pharmacy and its consequences need to be taken into account. In applying modern treatment paradigms to the elderly, the clinician must consider the potential for more pronounced adverse effects in this vulnerable group and set appropriate boundaries maximizing benefit and minimizing harm".

Green peas are species of Pisum Sativum belongings to the family Fabaceae and native to western Asia from the Mediterranean Sea to the Himalaya Mountains. The pea is a green, pod-shaped vegetable and a cool-season crop grown in many parts of the world.

On finding a potent ingredient for the treatment of inflammatory bowel disease, researchers investigated the impact of green pea (GP) supplementation on the susceptibility of high-fat diet (HFD)-fed mice to dextran sulfate sodium (DSS)-induced colitis.

The study included 6-week-old C57BL/6J female mice fed a 45% HFD or HFD supplemented with 10% GP. for 7-week before colitis was induced by adding 2.5% DSS in drinking water for 7 days followed by a 7-day recovery period.

Based on the tested analysis, BP supplement showed a significant effect in ameliorating the disease index score in HFD-fed mice during the recovery stage by reducing neutrophil infiltration and chemokine associated with a pro-inflammatory response.

Furthermore, pro-inflammatory markers in the tested mice such as interleukin (IL)-6, cyclooxygenase-2 (COX-2), IL-17, interferon-γ (IFN-γ) were also inhibited by the administration of GP supplement.

Moreover, the mucin 2 content and goblet cell differentiation markers associated with the protection of digestive functioning were significantly increased by the GP supplement.

Additionally, the endoplasmic reticulum (ER) stress induced by the 2.5% DSS that cause digestive cell dysfunction was inhibited by the GP application.

Based on the findings, researchers wrote, "GP supplementation ameliorated the severity of DSS-induced colitis in HFD-fed mice, which was associated with the suppression of inflammation, mucin depletion, and ER stress in the colon".

Taken altogether, green peas may be considered a functional food for the prevention of inflammatory bowel disease, pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) Dietary Green Pea Protects against DSS-Induced Colitis in Mice Challenged with High-Fat Diet by Bibi S1, de Sousa Moraes LF2, Lebow N3, Zhu MJ. (PubMed)

Sunday, 1 September 2019

Broccoli Sprout Inhibits Parameters Associated with Sickle Cell Anemia

By Kyle J. Norton

Anemia is a medical condition associated with a lack of healthy red blood cells or hemoglobin in the blood.

Iron deficiency anemia is one of the most common anemia, caused by poor iron levels in the blood, leading to the reduced delivery of oxygen throughout your body.

A long-term deficiency of folate and vitamin B-12 plays a critical role in the production of healthy red blood cells associated with the increased risk of Amenia.

Also, people with the mutated gene inherited from the parent are at substantial risk of the disease. The Duliajan College study suggested that certain genes have been found to induce anemia.

Sickle cell anemia (SCD), a genetic preposition form of anemia is a condition associated with not enough healthy red blood cells to carry adequate oxygen throughout your body.

The red blood cells in sickle cell anemia patines are rigid and sticky with the shapes of sickles or crescent moons.

The normal red blood cells live for about 120 days comapred to the sickle cells that die in 10 to 20 days. In other words, the inability of the body to replace the cell that dies rapidly with new blood cells is a cause of sickle cell anemia.

According to the statistics, provided by the CDC, approximately 100,000 Americans are living with SCD. Ethnically, 1 out of every 365 Black or African-American births, 1 out of every 16,300 Hispanic-American births and 1 in 13 Black or African-American birth are sickle cell trait (SCT) carriers.

Conventionally, except for bone marrow transplant, treatments of sickle cell anemia is to improve quality of life, by relieving symptoms and preventing complications.

Collard Green is a species of Brassica Oleracea, belongings to the family Brassicaceae with unknown origin. Today, the plant is cultivated commercially for its thick, slightly bitter edible leaves.

With an aim to find a potential ingredient for the treatment of inherited blood disorder, researchers examined the effects of broccoli sprout homogenate (BSH) containing sulforaphane and sulforaphane in the activation of NRF2 on sickle cell disease (SCD).

Nrf2 is a protein that processes the function in the regulation of the expression of antioxidant enzymes against oxidative damage triggered by injury and inflammation.

According to the tested analysis, sulforaphane (SFN) significantly increased the expression of NRF2 associated with the increase of antioxidant enzymes that inhibits oxidative stress such as HMOX1, NQO1, and HBG1 in a dose-dependent manner.

In adults with SCD,

* BSH consumption showed no adverse effects.

* BSH consumption increase the mean relative whole blood mRNA levels NRF2 target HMOX1

* Furthermore, BSH injection increased mean relative mRNA levels of the NRF2 target HBG1, compared to the baseline at end of treatment, without affecting the levels of HbF protein.

In other words, BSH displays a similar effect compared to that of sulforaphane in the promotion of the production of antioxidant enzymes against sickle cell disease (SCD).

Based on the findings, researchers said, "BSH, in the provided doses, is safe in stable SCD patients and may induce changes in gene expression levels".

Taken altogether, broccoli sprout processed abundantly SFN may be considered a functional food for the treatment of SCD, pending to the confirmation of the larger sample size and multicenter human study.

Intake of SFN in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Phase 1 Study of a Sulforaphane-Containing Broccoli Sprout Homogenate for Sickle Cell Disease by Doss JF1,2, Jonassaint JC3, Garrett ME4, Ashley-Koch AE4, Telen MJ3, Chi JT. (PubMed)

Herbal Turmeric the Best for the Treatment of Gout and Recurrent Gout

By Kyle J. Norton

Gout, a painful and recurrent condition mostly affected one joint is a type of arthritis caused by uric acid building up in the blood that induces joint inflammation.

Epidemiologically, high levels of uric acid found in the body that leads to the forming of crystals are the culprit, as a result of the inability of the kidney to get rid of uric acid.

Most cases of gout are found in patients who follow the diet with a high intake of meats and seafood and foods containing higher levels of purine such as alcoholic beverages, especially beer, and drinks sweetened with fruit sugar (fructose).

Reduced intake of aforementioned products has been found to reduce the onset of recurrence of the condition in many previous patients.

Believe it or not, most patients with gout and recurrent gout also associated with medical conditions of hypertension, renal insufficiency, and hypertriglyceridemia.

Furthermore, the increase of the level of uric acid not only significantly raises the risks of gout, but also the risk of cardiovascular disease, and type 2 diabetes.

Dr. LÁlvarez-Lario B, the lead scientist at the Hospital Universitario de Burgos wrote, "Gout is characterized not only by an increase in uric acid, eventual episodes of arthritis, and chronic joint damage but also by association with several comorbidities and increased cardiovascular risk. The adoption of more healthier dietary habits may contribute to better management of uricemia and also to a reduction of associated diseases".

In other words, by a change of lifestyle and moderate exercise, gout may be manageable or preventable.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential compound for the treatment of gout with no side effect, researchers examined the effect of turmeric nanoparticles (T-NPs) against gout, in vitro and in vivo.

The T-NPs developed were about 46 nm in size with a positive zeta potential +29.55 ± 3.44 and low polydispersity index (PDI).

In mice induced gout by monosodium urate crystals, T-NPs administered orally showed a significant effect in the treatment of gout and gout symptoms with 5, 10, and 20 ppm.

All parameters associated with the development of gout were inhibited by the injection T-NPs regardless of doses.

In other words, T-NPs inhibited gout by improving the lipid profile, renal, and liver function involved in the expression of the levels of uric acid, observed by the tested assays.

Dr. the lead scientist said, "Uric acid levels were significantly reduced after the treatment with T-NPs. indicating that T-NPs show superior potential against gout management".

Taken altogether, turmeric in the form of turmeric nanoparticles (T-NPs) may be used for the treatment of gout, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Evaluation of Turmeric Nanoparticles as Anti-Gout Agent: Modernization of a Traditional Drug.
Kiyani MM1, Sohail MF2,3, Shahnaz G4, Rehman H5, Akhtar MF6, Nawaz I7, Mahmood T8 bt Manzoor M9, Bokhari SAI. (PubMed)
(2) [Hyperuricemia and gout; the role of diet].[Article in Spanish; Abstract available in Spanish from the publisher] by bÁlvarez-Lario B1, Alonso-Valdivielso JL2. (PubMed)

Onion Promotes Healthy Gut Microbiota

By Kyle J. Norton

Gut microbiota is a community of microbes living in the gastrointestinal tract, including at least 1000 different species of known bacteria with more than 3 million genes.

In a healthy individual, the ratio of good and bad microbes in the gut are balanced. However, people who have a psychological condition such as anxiety, and depression, and are under constant stress and long-term use of antibiotics, particularly your diet may have a negative impact on the ratio.

More precisely, under normal conditions, gut microbiota plays a critical role in overall health,
* Gut microbiota improves the absorption of the dietary nutrients of the digestive system

* Gut microbiota protects the body against xenobiotics and drug toxicity through facilitating the excretion.

* Gut microbiota also maintains the structural integrity of the gut mucosal barrier by enhancing the epithelial cells that protect the intestine against invasive pathogens and ensure the function of intestinal in nutrients adsorption.

* Gut microbiota interacts with the immune system against inflammatory immune disorders and inhibits the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.

However, imbalanced of the ratio of gut microbiota may have a negative impact on human health and diseases.

Epidemiological studies suggested imbalanced gut microbiota dysbiosis found in overweight and obese has been found to promote diet-induced obesity and metabolic complications.

Dr. KarinaAl-Ass wrote, "Obesity is a worldwide epidemiologic syndrome characterized by fat mass accumulation, mainly visceral fat. Current thinking considers the potential role of gut microbiota on the development of obesity and its related comorbidities"

And " Gut microbiota can influence energy extraction from food, lipid metabolism, immune response, and endocrine functions and its profile has shown to differs between obese and lean subjects".

A recent joint study led by the Tianjin Medical University, General Hospital, onion supplement may be potent to improve gut microflora and intestinal histomorphology on an animal model.

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

The study included a total of 300 and 12-day old broiler chicks (Ross) that randomly divided into four groups as A served as the control without any supplementation, and B, C, and D received supplemented with onion powder at the rate of 1.5, 2 and 2.5g/kg of feed respectively.

Based on the tested results,

* Supplementation of onion exerted a significantly (P<0.05) increased weight gain and feed consumption compared to control.

* Furthermore, supplementation of onion significantly inhibited the population of E. coli and increased significantly Lactobacillus and Streptococcus species.

In other words, onion supplement promotes colon health by improving the ratio of gut microbiota.

* More importantly, injection of onion supplement also significantly increase the morphometry of length, width, crypt depth and surface area of the villus in duodenum, jejunum, and ileum of the small intestine associated with the colon health optimization.

Based on the findings, researchers said, "onion supplementation in broiler produced a positive effect on performance, gut microflora, and intestinal histomorphology".

Taken altogether, onion processed a higher mount of onionin A (ONA) may be considered a remedy for the promotion of colon health, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of Quercetin Monoglycosides on Oxidative Stress and Gut MicrobiotaDiversity in Mice with Dextran Sodium Sulphate-Induced Colitis by Hong Z1, Piao M. (PubMed)
(2) In vivo effects of Allium cepa L. on the selected gut microflora and intestinal histomorphology in broiler by Ur Rahman S1, Khan S1, Chand N1, Sadique U2, Khan RU. (PubMed)
(3) Gut microbiota and obesity by Karina Al-Assal, Ana Cristina Martinez, Raquel SusanaTorrinhas, Camila Cardinelli, Dan Waitzberg. (Science Direct)