Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Friday, 5 July 2019

Phytochemical Alliin, the Potent Antioxidant

By Kyle J. Norton

Antioxidants are stable atoms produced by the host or from the dietary sources with a function that inhibit free radicals.

Free radicals are the unstable atoms with highly reactive nature and single electron on the outermost ring. Therefore, in order for them to become stable, free radicals are ready to intercept or donate an electron to other stable atoms, leading to a chain reaction that can not be stopped until all electrons on the outermost ring are paired or inhibited by antioxidants.

Oxidative stress is a condition associated with overexpression of free radicals compared to low levels of antioxidants in the body. Over time, oxidative can cause protein, lipid, and cellular damage, leading to cells injury and death that facilitate the onset of chronic diseases, including CVD and cancer.

Believe it or not, free radicals at a moderate level are necessary for the body function, including maintaining the heart in the regulation of relaxation and constriction. However, if levels of free radical presented with a large amount, they can cause heart disease.

Most common types of free radical include

* Hydroxyl radical (OH•)
The hydroxyl radical is the neutral form of the hydroxide ion (OH–) produced from the decomposition of hydroperoxides (ROOH) by the reaction of an elevation in energy level above an arbitrary baseline energy state molecular oxygen.

* Superoxide anion radical (O2–•)
A superoxide anion is a compound that possesses an atom or molecule in which the total number of electrons is not equal to the total number of protons, giving it a net positive or negative electrical charge with the chemical formula O2− with one unpaired electron, leading to the generating of superoxide anion free radical.

* Singlet oxygen
Singlet oxygen is the common name used for the diamagnetic form of molecular oxygen (O2), which is less stable than the normal triplet oxygen.

* Hydrogen peroxide
Hydrogen peroxide (H2O2) is the simplest peroxide, a clear liquid, slightly more viscous than water, that appears colorless in dilute solution. It is considered a highly reactive oxygen species because of its strong oxidizing capacity.

* Lipid peroxyl free radical
Lipid peroxidation is a process in which free radicals steal electrons from the lipids in cell membranes, most often affecting polyunsaturated fatty acids, that can lead to cell membrane damage.

* Nitric oxide
Nitric oxide is a chemical compound with chemical formula NO. Even though low levels of NO production are important in protecting the liver from ischemic damage and contributing to proper smooth muscle contraction and growth, but its free radical and toxic nature can cause DNA damage and inflammation.

* Alkoxyl radical
Alkoxyl radical which is an alkyl (carbon and hydrogen chain) group singular bonded to oxygen can result in cellular damage caused by oxyfluorfen, a herbicide.

*Peroxynitrite
Peroxynitrite is the anion with the formula ONOO−reacted quickly with carbon dioxide, leading to forming of carbonate and nitrogen dioxide radicals.

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

On finding a natural ingredient for the treatment of diseases associated with oxidative stress, researchers investigation the alliin antioxidant effects.

By comparing four main chemical classes, alliin, allyl cysteine, allyl disulfide, and allicin, prepared by chemical synthesis or purification, researchers found that
* Alliin was the best free radical scavenged superoxide, compared to others phytochemicals.
* Allicin suppressed the formation of superoxide by inhibiting the xanthine/xanthine oxidase system associated with the generation of ROS.

* The antioxidant activity induced by alliin was probably associated with a thiol exchange mechanism, a chemical reaction in which a thiolate group −S− attacks a sulfur atom of a disulfide bond −S−S−.

* Hydroxyl radicals were also inhibited by alliin.

* However, alliin did prevent alliin, allicin microsomal lipid peroxidation.

Based on the findings, researchers wrote, "both alliin and allyl cysteine were hydroxyl scavengers, and allyl disulfide was a lipid peroxidation terminator"

In other words, alliin protects the body against the overexpression of free radicals in the induction of a chain reaction to cause lipid and cellular damage.

Dr, Chung LY again in the summary, said, " our findings indicated that allyl disulfide, alliin, allicin, and allyl cysteine exhibit different patterns of antioxidant activities as protective compounds against free radical damage".

Taken altogether, alliin may be considered supplements for the prevention and treatment of diseases associated with oxidative stress, pending on the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Turmeric Protects the Liver cells Damage Against the Risk of Liver Disease

By Kyle J. Norton

Liver formed part of the detoxed organs in the human body is the largest internal organ that filters the blood from the digestive tract, before passing them to the rest of the body.

The liver also plays an essential role to produce cholesterol to build a strong cell wall, produce steroid hormones and vitamin D and aid the digestive function in food absorption and detoxify toxic chemicals and metabolizes drugs.

Liver disease is a process of reduced function of the liver acutely or gradually.

Liver cancer is a chronic liver disease associated with irregular cell growth that starts in the cells on the surface of the liver inner lining tissue, before penetrating into deeper layers to form tumor through cell proliferation.

At the advanced stage, the cancerous cell in the primary liver cancer can travel a distance away to infect other nearby healthy tissue or organ, via blood and fluid circulation, leading to secondary metastasis.

Liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide.
Hepatocellular carcinoma (HCC) is a common form of primary liver cancer.

According to the Canadian Liver Foundation, approximately one in ten Canadians, or more than 3 million people in Canada has some form of liver disease,

Believe it or not, 95% of deaths from liver disease are due to chronic hepatitis B and C, alcoholic liver disease, non-alcoholic fatty liver disease, and liver cancer, including 25% of obese patients.

Most common signs and symptoms of liver disease are jaundice, abdominal pain, and swelling in the legs and ankles, itchy skin, dark urine color, pale stool color, or bloody or tar-colored stool and tendency to bruise easily.

If you have experienced some of the aforementioned symptoms that do not heal in a short period of time, please check with your doctor to rule out the possibility.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potent compound for the prevention of liver disease, researchers examined the liver protective effect of curcumin.

Curcumin showed a strong antioxidant activity that protects the liver against several mechanisms involved in hepatotoxicity, leading to cell membrane disruption, and initiation of the immune response.

Furthermore, the bioactive ingredient also improved the cellular pathways of drug metabolism and inhibited the accumulation of reactive oxygen species (ROS) that cause liver damage.

Lipid peroxidation that leads to cell death caused by overexpression of free radicals in facilitating the chain reaction has also blocked the presence of curcumin.

Moreover, in various protocols of hepatotoxicity such as acetaminophen, alcohol, lindane, carbon tetrachloride (CCL4), diethylnitrosamine and heavy metals induced hepatotoxicities, injection of curcumin also showed significant efficacy in protecting the liver against damage, observed by reduced liver stress markers.

These results strongly suggested that curcumin is strong anti-oxidant and anti-inflammatory effects and thus it possesses hepatoprotective properties.

Collectively, researchers wrote, "the hepatoprotective effects of curcumin with a focus on its mechanistic insights in various hepatotoxic protocols".

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of liver disease, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Identification of a Quality Marker of Vinegar-Processed Curcuma Zedoaria on Oxidative Liver Injury by Cui H1, Zhang B2, Li G3, Li L4, Chen H5, Qi J6, Liu W7, Chen J8, Wang P9, Lei H. (PubMed)
(2) Mechanistic insights of hepatoprotective effects of curcumin: Therapeutic updates and future prospects by Khan H1, Ullah H2, Nabavi SM. (PubMed)

Collard Greens Improves the Build-up of Bone Density Against Osteoporosis

By Kyle J. Norton

Bone density is also known as bone mineral density associated with the amount of bone mineral in bone tissue. The concept of bone density has been used to measure the mass of mineral per volume of bone to identify people in the risk and onset of osteoporosis.

Osteoarthritis (OA) is a common chronic inflammatory joint disease characterized by the breaking down of joint cartilage and the underlying bone, mostly in the women in the menopause and older adult, leading to symptoms of joint pain, tenderness, and lack of flexibility and stiffness.

Some osteoporotic patient may also experience symptoms of grating sensation and bone spurs.

Aging, genetic preposition, overweight, and obesity, injury, and overuse of the joints are the most common risk factor associated with the onset of the disease. However, occupation with the repetitive movements of the joint has been found to affect people in the industrial world.

Interestingly, osteoarthritis symptoms can come and go throughout the day and vary from person to person. The weather change has been one of the most complaints that trigger the symptoms of OA in the elderly.

According to the statistics, approximately, more than 200 million people are suffering from osteoporosis, including 44 million Americans with either osteoporosis or low bone mass and 1 in 3 women over the age of 50 years and 1 in 5 men will experience osteoporotic fractures in their lifetime.

Dr. Jakob F, the lead scientist in the study of the risk of osteoporosis in aging population wrote, "Age is a high-risk factor for osteoporosis. Vitamin D insufficiency and reduced calcium absorption are common in the elderly. Loss of bone and muscle development in a vicious circle of immobilization caused by underlying diseases. In addition deficits in cognition and coordination promote falls and fragility fractures".

And, "Specific medication is indicated if the 10-year fracture risk exceeds 30 %, wherein women > 75 and in men > 85 years of age bone density measurement can be relinquished".

Collard Green is a species of Brassica Oleracea, belongings to the family Brassicaceae with unknown origin. Today, the plant is cultivated commercially for its thick, slightly bitter edible leaves.

With an aim to find a natural compound for the treatment of osteoporosis, researchers examined the effects of sulforaphane (SFN) on age-related shifts in anabolic and catabolic responses.

According to the tested differentiation, in both normal and ovariectomized mice that treated with SFN for 5 weeks, sulforaphane (SFN), a naturally occurring in collard greens promotes osteoblast differentiation by epigenetic mechanisms associated with enhancing the production of bone density.

Furthermore, SFN enhanced active DNA demethylation via Tet1 and Tet2 involved in the production of bone cells against the pathogenesis of osteoporosis and promoted pre-osteoblast differentiation by enhancing extracellular matrix mineralization and the expression of osteoblastic markers in the process of making new bone cells.

Where Tet loss has been associated with abnormal osteoclast function.

Moreover, SFN inhibited the expression of the osteoclast activator RANKL in osteocytes associated with bone reabsorption and induced apoptosis in pre-osteoclastic cells through the several mechanisms involved in bone degenerative pathology.

The results suggested that these mechanistic effects not only lowers the rate of bone reabsorption but also accelerates the production of higher bone volume.

More importantly, SFN protected the bone density against the shifts in mineral density distribution observed by quantitative back-scattered electron imaging (qBEI).

Based on the findings, researchers concluded, "Our data indicate that the food-derived compound SFN epigenetically stimulates osteoblast activity and diminishes osteoclast bone resorption shifting the balance of bone homeostasis and favor bone acquisition and/or mitigation of bone resorption in vivo".

Taken altogether, collard green processed a higher amount of sulforaphane (SFN) may be considered supplements for the prevention and treatment of osteoporosis, pending to the confirmation of the larger sample size and multicenter human study.

Intake sulforaphane (SFN) in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anabolic and anti-resorptive modulation of bone homeostasis by the epigenetic modulator sulforaphane, a naturally occurring isothiocyanate by Roman Thaler1,2, Antonio Maurizi3 , Paul Roschger1 , Ines Sturmlechner1 , Farzaneh Khani2 , Silvia Spitzer1 , Monika Rumpler1 , Jochen Zwerina1 , Heidrun Karlic1 , Amel Dudakovic2 , Klaus Klaushofer1 , Anna Teti3 , Nadia Rucci3*, Franz Varga1*, Andre J. van Wijnen by (JBC Paper in Press)
(2) [Age and osteoporosis. Effects of aging on osteoporosis, the diagnostics and therapy].[Article in German] by Jakob F1, Seefried L, Schwab M. (PubMed)

Thursday, 4 July 2019

Healthy Food Cucumber's Cucurbitacin B (CuB), the Best Liver Detoxed Remedy Against Alcohol Toxicity

By Kyle J. Norton

Alcohol toxicity is a result of excessive consumption of alcohol that leads to alcohol poisoning.

People with a high level of blood alcohol may experience symptoms of confusion, unresponsive, and disorientation.

If severe cases, patients may loss of conscientiousness or go into a coma.

Long- term excessive alcohol consumption may cause liver damage, leading to the symptoms of jaundice, cirrhosis, liver failure, and liver cancer.

Some people may experience symptoms of alcohol withdrawal symptoms after a day of heavy drinking day. Depending on the body response, some people may experience alcohol withdrawal symptoms as early as two hours after the last drink.

However, most people may experience the symptoms as soon as they wake up after a night of sleep. The symptoms will peak within the first 24 to 48 hours.

Most common alcohol withdrawal symptoms are a rapid heartbeat, changes in blood pressure, sweating, tremors, and fever.

The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to find a natural compound which processes anti-alcoholic toxicity, researchers investigated the heat-treated cucumber juice protective effect on blood alcohol levels and hepatic alcohol metabolic enzyme system in experimental rats.

The study included alcoholic toxicity rats orally dosed to 22% alcohol (6ml/kg body weight) along with different concentrations of heat-treated cucumber juice (10, 100 and 500mg/kg) and commercial goods for hangover-removal on sale (2ml/kg).

According to the tested results, after 7h, all concentrations of heat treated cucumber remarkable reduced the blood alcohol levels.

Furthermore, levels of dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) enzymatic activities associated with a detoxicity in rat liver at 9h after alcohol administration were also increased in the treated rats.

The effect of heat-treated cucumber juice on alcohol detoxification was observed only in the rats treated before 30min from alcohol administration may be involved in stimulated blood alcohol metabolism.

Based on the finding, researchers said, "These findings indicate that heat-treated cucumber juice has a significant protective effect on alcohol detoxification in experimental rats, suggesting its usefulness in the treatment of the liver injury caused by alcohol consumption".

Taken altogether, heat-treated cucumber may be used for the prevention and treatment of alcoholic toxicity, pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) Protective effect of heat-treated cucumber (Cucumis sativus L.) juice on alcoholdetoxification in experimental rats by Bajpai VK1, Kim NH2, Kim JE3, Kim K4, Kang SC. (PubMed)
(2) NADPH-dependent reductases involved in the detoxification of reactive carbonyls in plants by Yamauchi Y1, Hasegawa A, Taninaka A, Mizutani M, Sugimoto Y. (PubMed)

Turmeric Suppresses the Formation of Plaque Against the Onset of Atherosclerosis

By Kyle J. Norton

Atherosclerosis is a condition caused by long-term plaques built-up on the wall of the arteries, leading to narrowing the arteries, a major cause of heart disease and stroke.

Plaque is made up of fat, cholesterol, calcium, and other substances found in the blood.

There are some stages of atherosclerosis, depending on the types of atheromatous plaques.

* In the early lesions or type I, foam cells of macrophage are localized to fatty deposits on blood vessel walls.

* Type II of atheromatous plaques are associated with contractile fibrils accumulated on the arterial wall that are not highly ordered and lipid infiltration.

* Type III is the stage caused by connective tissue deposition that is thicker and less cellular than the normal intima, leading to fluid motion characterized by chaotic changes in pressure and flow velocity in the artery.

The above development may take years to develop. Patients with hypertension, diabetes mellitus, hypercholesterolemia, and who smoke. are found to accelerate the time of onset.

* Type IV and V are stages that the condition in type III now has become a softer plaque with thinner fibrous cap, containing macrophages and smooth muscle cells.

At stage V, aterial plaques are more volnerble to disruption.

Some researchers suggested that the promotion of a high-fat diet in the western world may be one of the major culprits that cause widespread atherosclerosis.

Dr. Zhao Y, the lead scientist said, " At 6 months, (high-fat diet fed group) plaque lesions appeared in the abdominal aorta and iliac artery, while at 8 months, they appeared in the coronary artery. At 12 months, atherosclerotic lesions could be found in all major arteries, while lipid core, cholesterol precipitation, and calcium deposition appeared in the most serious sites".

And, "The progression of arterial lesions and distribution of the lesions were highly consistent in the pigs".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a potential ingredient for the treatment of atherosclerosis, researchers examined the effect of curcumin, a bioactive compound found in turmeric in modulating the expression of proinflammatory M1 and anti-inflammatory M2 macrophages against atherosclerotic plaques.

According to the assays from vitro and in vivo, researchers found that curcumin not only exerts lipid-lowering effects, and also can modulate the function of different macrophage subsets in various macrophage-involved diseases, including atherosclerosis.

In order to reveal more information about curcumin anti the development of atherosclerosis, researchers investigated the effect of a supplement containing Curcuma longa, silymarin, guggul, chlorogenic acid and inulin on NAFLD and atherosclerosis.

The study included C57BL/6 mice fed an HFD for 16 weeks followed by a treatment of a daily oral administration (os) of the NDS on half of the mice.

According to the PCR assay, NDS showed not only exhibited the genes involved in lipid metabolism and anti-inflammatory activity (Cpt2, Ifng) but also inhibited the genes involved in pro-inflammatory response and in free fatty acid uptake (Fabp5, Socs3).

Compared to the untreated group, injection of NDS also displays liver protective activity by significantly lowering hepatic angiotensinogen (AGT) and AT₁R mRNA expression (real-time PCR) and plasma angiotensin (ANG)-II levels (ELISA)plasma levels, the indication of hepatocellular impairment and overexpression of pro-inflammatory cytokines in facilitating onset of M1 macrophages.

Additionally, NDS exerted a similar effect as seen in the aforementioned study by protecting the arteries against plaques accumulation caused by imbalanced levels of M1 and M2 macrophages in populated growing atherosclerotic lesions.

Based on the findings, researchers said, " these results suggest that NDS prevents NAFLD and atherogenesis by modulating the expression of different genes involved in NAFLD and avoiding RAS imbalance".

Taken altogether, turmeric processed a high amount of curcumin may be considered supplements for the prevention and treatment of atherosclerosis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin as a potential modulator of M1 and M2 macrophages: new insights in atherosclerosis therapy by Momtazi-Borojeni AA1,2, Abdollahi E3,4, Nikfar B5, Chaichian S6,7, Ekhlasi-Hundrieser M8. (PubMed)
(2) NAFLD and Atherosclerosis Are Prevented by a Natural Dietary Supplement Containing Curcumin, Silymarin, Guggul, Chlorogenic Acid and Inulin in Mice Fed a High-Fat Diet by Amato A1, Caldara GF2, Nuzzo D3, Baldassano S4, Picone P5, Rizzo M6, Mulè F7, Di Carlo M. (PubMed)
(3) Atherosclerosis Induced by a High-Cholesterol and High-Fat Diet in the Inbred Strain of the Wuzhishan Miniature Pig by Zhao Y1, Xiang L1, Liu Y1, Niu M1, Yuan J1, Chen H. (PubMed)

Red Cabbage Processes the Cardio-protective Activity

By Kyle J. Norton

Cardioprotection is a process including the use of substances associated with the preserve of the function and viability of cardiac muscle tissue by the reintroduction of oxygenic blood flow back to the tissues.

Cardiovascular disease (CVD) is a group of conditions caused by the underlying damage of blood vessels and the heart.

More precisely, CVD can be coronary artery diseases (CAD) such as angina, myocardial infarction (commonly known as a heart attack) or stroke, depending on the location of the blockage or disruption,

According to the statistics provided by the American Heart Association, approximately 84 million people in this US living with some form of cardiovascular disease. The condition has also been found to cause the death of about 2,200 people a day.

The exact causes of CVD are not identified. however, the most prevalent factors that cause CVD are aging, family history, unhealthy diet, lack of exercise, being overweight and smoking.

Believe it or not, most patients who suffered from CVD are also associated with atherosclerosis, a condition caused by long-term plaque build-up on artery walls, that lead to narrow the arteries and reduce blood flow through your arteries to the heart.

Metabolic factors including hyperglycemia, hyperlipidemia, and hyperkalemia are the most common syndromes that have been found to promote CVD.

Where hyperglycemia, hyperlipidemia, and hyperkalemia are conditions of abnormally high levels of sugar, cholesterol and potassium level in the bloodstream, respectively.

Dr. Gumbiner B, the lead scientist wrote, "Risk factors for cardiovascular disease (CVD) appear to cluster in individuals, possibly because of a single, underlying metabolic disorder".

And, " Abnormal metabolic risk factors were defined as (1) an abnormal glucose value (fasting blood sugar greater than 115 mg/dl); (2) abnormal lipids (high-density lipoprotein cholesterol under 35 mg/dl in men or under 45 mg/dl in women; or low-density lipoproteins of 160 or greater; or triglycerides greater than 250 mg/dl), and (3) hypertension (blood pressure systolic above 160 mmHg; or diastolic above 90 mmHg)".

Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem with a crowded mass of leaves, usually green but in some varieties, it may be red or purplish.

On findings a natural wholefood for the prevention of cardiovascular disease, researchers examined the effects of Brassica vegetables such as red cabbage on the alleviation in experimentally induced myocardial infarction.

H2O2 induced rat neonatal cardiomyoblasts (H9c2 cells) treatment associated with cytotoxicity (48-50%) and apoptosis (57.3%), were reduced by the application of anthocyanin-rich red cabbage extract (ARCE).

Furthermore, in isoproterenol (ISO) induced rodent model of myocardial infarction, pretreated ARCE for 30 days recorded a significant increase of heart body weight ratio as compared to the ISO-treated group.

ARCE pretreatment also prevents the effect of ISO on the induction of the depletion of enzymatic antioxidants and apoptosis.

Moreover, ISO-induced infracted areas (10%) and derangement of the myocardium was also inhibited by the pretreatment of ARCE.

Additionally, ISO-induced heart cells membrane damage and heart calcium imbalance were also attenuated by the pretreatment of ARCE.

In other words, ARCE protected heart integrity against the isoproterenol (ISO) induced damage to the heart muscle.

Based on the results, researchers wrote, "Overall this study elucidates the mechanism of ARCE mediated prevention of experimentally induced myocardial damage".

Taken altogether, red cabbage may process cardioprotective activity, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anthocyanin rich extract of Brassica oleracea L. alleviates experimentally induced myocardial infarction by Jana S1, Patel D1,2, Patel S1, Upadhyay K1, Thadani J1, Mandal R3, Das S3, Devkar R. (PubMed)
(2) Metabolic risk factors for cardiovascular disease in a working population: a retrospective cohort study by Gumbiner B1, Andresen EM, Hearne FT, Michaelson TE, Bryson M, Lednar WM, Cass R. (PubMed)

Brocoli Inhibits the Symptoms of Diabetes

By Kyle J. Norton

Type I diabetes is also known as juvenile diabetes or insulin-dependent diabetes associated with not enough or no insulin produced by the pancreas due to the die-off or gradual die-off the insulin-producing beta cells

The exact causes of type I diabetes are not identified. However, the condition is a result of the body's own immune system mistakenly that destroys the insulin-producing cells in the pancreas.

Type II diabetes is a chronic acquired medical condition characterized by insufficient insulin entering the bloodstream to regulate the glucose.

The disease is either caused by cells in pancreas die-off or receptor sites clog-up by fat and cholesterol.

In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

The exact cause of type II diabetes is also unknown. However, some researchers suggested that the condition is most likely caused by genetic mutation and an unhealthy lifestyle.

Untreated and unmanageable type I and II diabetes may induce complications of cardiovascular disease, nerve damage (neuropathy), kidney damage (nephropathy), eye damage (retinopathy). foot damage and skin conditions.

Medication used for the treatment of diabetes is focused on alleviating the symptoms and improving quality of life, particularly, in type II diabetes in slowing down the progression of the disease.

Dr. Waqas Sami, the lead author in the study "Effect of diet on type 2 diabetes mellitus: A review" wrote. "Dietary habits and sedentary lifestyle are the major factors for the rapidly rising incidence of DM among developing countries. In type 2 diabetics, recently, the elevated HbA1c level has also been considered as one of the leading risk factors for developing microvascular and macrovascular complications".

And, "Improvement in the elevated HbA1c level can be achieved through diet management; thus, the patients could be prevented from developing diabetes complications. Awareness about diabetes complications and consequent improvement in dietary knowledge, attitude, and practices lead to better control of the disease".

These results suggested changes in diet and lifestyle are the most effective method in the management of type II diabetes.

Other risk factors associated with the early onset of type II diabetes include overweight or obese, age 45 or older, family history, ethnicity, Alaska Native, high blood pressure and cholesterol and women with polycystic ovary syndrome

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower head surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

With an aim to find a potential wholefood for the treatment of diabetes, researchers examined the effect of broccoli on type 2 diabetes.

The study included SD rats induced type 2 diabetes mellitus (T2DM) by a high-fat diet and injecting a low dose (35 mg/kg) of streptozocin were pretreated by treated broccoli extracts at a dose of 200, 400 and 800 mg/kg body weight for 28 days.

According to the tested assays at the 28-day, broccoli extracts showed an improvement in body weight, water, and food intake compared to diabetic control rats.

Compared to the doses viz., 200, 400, 800 mg/kg body weight demonstrated a significant attenuation in the blood glucose at 180 min in Streptozotocin (STZ) induced diabetic rats, also compared to control.

Based on the findings, researchers wrote in the final report, "The study demonstrated that ethanolic extract of Brassica oleracea extract has potential antidiabetic activities. Thus Brassica oleracea as a vegetable or its extract can be useful to control hyperglycemia".

Taken altogether, broccoli may be considered a functional food for the prevention and treatment of type 2 diabetes, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antidiabetic Potential of Brassica Oleracea Var. Italica in Type 2 Diabetic Sprague Dawley (SD) Rats by Mashood Ahmad Shah, Moklesur Rahman Sarker, and Mohammad GOUSUDDIN Inamdar. (Reseach Gate)
(2) Effect of diet on type 2 diabetes mellitus: A review by Waqas Sami,1,2 Tahir Ansari,3 Nadeem Shafique Butt,4 and Mohd Rashid Ab Hamid. (PubMed)