Bromelain Inhibits the Parameters Associated with The Onset of Alzheimer's disease

By Kyle J. Norton


 Alzheimer's disease (AD) is a neurodegenerative disease correlated with major reductions of neurons to the respective target areas, named after German physician Alois Alzheimer.

Alzheimer's destroys brain cells, causing cognitive modalities severe enough to affect language communication, memory, lifelong hobbies or social life. Alzheimer's gets worse over time, and it is fatal.

According to statistic, over 25 million people in the world today are affected by dementia and most are suffering from Alzheimer's disease. In Canada, approximately, over half a million Canadians living with dementia accompanied by the 25,000 new cases diagnosed every year.

Believe or not, in 2016, dementia had cost Canada over $10 billion, including the health-care system and out-of-pocket caregiver costs.

Epidemiologically, cigarette smoking, midlife high blood pressure and obesity, diabetes, and cerebrovascular lesions and psychosocial factors (eg, high education, active social engagement, physical exercise, and mentally stimulating activity) are associated with prevalent risk of AD  developing.

Some researchers in the evaluated the increased AD in the older adults in the Western world over the past few decades may be correlated to the promotion of the high-fat diet.

Dr. Peter Thériault, the lead researcher wrote, "WD promotes systemic inflammation by increasing the levels of blood-circulating monocytes and monocyte chemotactic protein-1 production, which is accompanied by an augmentation of oxidized-low density lipoprotein levels in blood circulation".

And, "At the blood-brain barrier (BBB), WD potentiates the age-induced increase of Aβ 1-40 accumulation and exacerbates the oxidative stress, specifically in cerebral microvasculature. These effects were accompanied by the dysfunction of pericytes, thus altering BBB functionality without compromising its integrity".

In other words, if you are high-diet follow, you are at high risk of AD developing.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

On finding a potential compound for the treatment of Alzheimer's disease, researchers investigated the ability of bromelain, a plant cysteine protease derived from pineapple stems interaction with synthetic Aβ42 monomers and oligomers.

According to the tested assays, bromelain protected the neuron successfully by degrading Aβ42 monomers and low and high molecular weight oligomers.

Examined the effects of bromelain preparations of 3 and 6 mU added to the cerebrospinal fluid (CSF), the levels of Aβ42 monomers and oligomers were significantly reduced, compared to that od the same standard Aβ42 preparations incubated in CSF without bromelain

Furthermore, the concentration of bromelain incubations with 0.1, 0.5, and 1 mU/ml were not toxic to the central nervous system.

Based on the findings, researchers said, "these results represent an important insight into the action of bromelain on Aβ42 oligomers, suggesting its potential use in the therapy of AD".

In order to know more information about bromelain anti-Alzheimer's disease activity, researchers examined a beta-degrading activity of diverse alpha 2-macroglobulin (alpha 2-M)-proteinase including trypsin, alpha-chymotrypsin, and bromelain (125)I-A beta 1--42.

The complex showed a strong degradation of (125)I-A beta 1--42.

In Ex vivo, oral administration of high doses of proteinases displayed an enhanced degradation of (125)I-A beta 1--42 in the blood of volunteers.

In other words, the complexes exhibited a significant A beta catabolism, thus reducing the risk of developing AD by preventing A beta accumulation in brain and vasculature.

Taken altogether, bromelain used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of Alzheimer's disease, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Bromelain Degrades Aβ1-42 Monomers and Soluble Aggregates: An In Vitro Study in Cerebrospinal Fluid of Alzheimer's Disease Patients by Sancesario GM1, Nuccetelli M2, Cerri A3, Zegeer J2, Severini C4, Ciotti MT5, Pieri M2, Martorana A3, Caltagirone C1,3, Nistico R5,6, Bernardini S. (PubMed)
(2) Alpha 2-macroglobulin-mediated degradation of amyloid beta 1--42: a mechanism to enhance amyloid beta catabolism by Lauer D1, Reichenbach A, Birkenmeier G. (PubMed)
(3) High fat diet exacerbates Alzheimer's disease-related pathology in APPswe/PS1 mice by Peter Thériault,1 Ayman ElAli,2 and Serge Rivest. (PMC)

Phytochemical 3,3'-Diindolylmethane Kills Triple Negative Breast Cancer Cells in Vivo and Vitro

By Kyle J. Norton


Unlike general breast cancer which processes either receptors for estrogen or progesterone and/or receptors with a protein called HER2, triple-negative breast cancer is a form of breast cancer that does not share the aforementioned characteristics.

In other words, triple-negative breast cancer does not have receptors of estrogen or progesterone or genetic preposition.

More importantly, triple negative breast cancer was found to infect women under the age of 40 and women of African or Asian ancestry in the US, compared to breast cancer in the White.

Particularly, according to the epidemiological study, younger women and in women of African ancestry are susceptible to a higher risk of basal-like triple negative breast cancers.

Compared to the malignant nature, triple-negative and basal-like breast cancers are highly invasive which can grow and spread quickly to other tissues and organs through lymph and blood.

Also compared to other breast cancer, with decreased risk after 5 years, triple-negative breast cancers have a substantial higher recurrent rate within 5 years after treatment.

Triple negative breast cancer shares the symptoms similar to those of breast cancer and risk factor except in the form of the genetic preposition.

According to Dr. Shimelis H, the lead scientist in the joint study led by the Mayo Clinic, said, "Pathogenic variants in BRIP1, RAD51C, and TP53 were associated with moderate risk (odds ratio > 2) of TNBC. Similar trends were observed for the African American population. Pathogenic variants in these TNBC genes were detected in 12.0% (3.7% non-BRCA1/2) of all participants".

And, "Multigene hereditary cancer panel testing can identify women with an elevated risk of TNBC due to mutations in BARD1, BRCA1, BRCA2, PALB2, and RAD51D". 

In other words, if you carry the mutated genes BARD1, BRCA1, BRCA2, PALB2, and RAD51D, you are at a higher risk of triple negative breast cancer.

In seeking a potential compound for the treatment of breast cancer, researchers reexamined the promising anticancer effects of novel C-substituted diindolylmethane (DIM) derivatives DIM-10 and DIM-14 in aggressive triple negative breast cancer (TNBC, MDA-MB-231) models.

In vitro studies, novel C-substituted diindolylmethane (DIM) derivatives DIM-10 and DIM-14 demonstrated strong anticancer effects.

NLC formulations. including DIM-10 and DIM-14 extended significant increase in oral bioavailability compared to poor permeability and poor oral bioavailability of DIM-10 and DIM-14 used alone in pharmacokinetic studies.

Futhermore, compared to DIM-10, DIM-10 used alone, the NLC formulation showed an increase in Cmax and AUC values by 4.73 and 11.19-folds.

Similar increased anti-aggressive triple negative breast cancer (TNBC) efficacy was also found in the DIM-14 NLC formulations.

In dogs, the DIM-10 NLC formulations showed an increase of 2.65 and 2.94-fold in Cmax and AUC, against triple negative breast cancer (TNBC) respectively.

Moreover, DIM-10 or DIM-14 NLC formulations demonstrated significant a reduction in tumor volumes TNBC models and treated animals.

Dr. Godugu C, the lead scientist after taking into account co and confounders wrote, "NLC formulation of both DIM-10 and 14 is effective in TNBC models".

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of triple negative breast cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Novel diindolylmethane derivatives based NLC formulations to improve the oral bioavailability and anticancer effects in triple negative breast cancer by Godugu C1, Doddapaneni R2, Safe SH3, Singh M. (PubMed)
(2) Triple-Negative Breast Cancer Risk Genes Identified by Multigene Hereditary Cancer Panel Testing by Shimelis H1, LaDuca H2, Hu C1, Hart SN3, Na J3, Thomas A3, Akinhanmi M1, Moore RM3, Brauch H4,5,6, Cox A7, Eccles DM8, Ewart-Toland A9, Fasching PA10,11,12, Fostira F13, Garber J14, Godwin AK15, Konstantopoulou I13, Nevanlinna H16, Sharma P15, Yannoukakos D13, Yao S17, Feng BJ18, Tippin Davis B2, Lilyquist J3, Pesaran T2, Goldgar DE18, Polley EC3, Dolinsky JS2, Couch. (PubMed)

Herbal Turmeric, a Natural Prevention and Treatment of Crohn's disease, Studies Showed

By Kyle J. Norton

Crohn's disease is a type of inflammatory bowel disease caused by the inflammation in the gastrointestinal tract.

The exact cause of Crohn's disease is not identified. However, some researchers suggested that people with the compromised immune system and genetic preposition are prone to the disease onset compared to people who do not

Most common symptoms of Crohn's disease are abdominal pain, severe diarrhea, fatigue, weight loss, and malnutrition.

If you are experiencing symptoms of severe abdominal pain accompanied by blood in the stool and persistent diarrhea, please check with your doctor right the way.

Risk factors of Crohn's disease include aging, family and person history, ethnicity, smoking and long-term use of Nonsteroidal anti-inflammatory medications.

.

Out of many risk factors that cause the onset of the condition, some researchers suggested that your risk of Crohn's disease is depending on where you live.

Dr. Pascal Michel wrote, "Crohn's disease (CD) is clinically expressed as a chronic affection of the gastrointestinal tract currently known to have a multifactorial etiology involving a complex pathophysiological host response modulated by genetic susceptibilities, demographic determinants, and environmental factors. With more than 20 cases per 100,000 person-years, the province of Quebec, Canada is among regions of the world with the highest reported occurrence of CD in relation to other places where comparable estimates are available".

And, "These findings suggest that known populational and regional factors derived through census information only explain a limited fraction of the geographical variation of CD incidence and lead to speculate that the effects of these factors may be incompletely captured (imperfect construction of proxy variables) or that other important factors remain unmeasured".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a natural ingredient for the treatment of Crohn's disease (CD), researchers at the Grand Valley State University compared the effects of Remicade to curcumin for the treatment of the condition.

The review study includes the search in electronic databases (ProQuest Medical Library, CINAHL Complete, and PUBMED) to locate and identify articles to meet a predetermined set of inclusion criteria, including articles published after 2007 in human participants 18 years or older.

Compared to Remicade in reducing TNF-a, the protein associated with inflammation in adults with CD, curcumin induced a 55 points mean reduction in the Crohn's Disease Activity Index, reduced the expression of IL-1 and levels of C-reactive protein (CRP), associated with elevated levels of proinflammatory cytokines in the colon, particularly in the reduced levels of TNF-a and PPMTase involved in the improvement of colorectal cancer outcomes.

Based on the findings, researchers said, "...Preliminary data would suggest using both would reduce LOR. Curcumin, even by itself, was found to be a cheap and safe way to reduce CD symptoms and inflammatory markers"

Furthermore, according to the study conducted by the Medical School of Marília in the search for articles associating curcuminoids and CD and UC on the database of MEDLINE-PubMed, curcumin demonstrated an intestinal protective effect on reducing oxidative stress and inhibiting the migration of neutrophils and inducible nitric oxide synthase in the intestine.

Moreover, curcumin also improved micro and macroscopic lesions in the gut, prevented apoptosis of intestinal cells and induced the restoration of immune reaction. 

 Dr. Cunha Neto F, after taking into account of co and confounders wrote, "The use of curcumin is cheap, efficient and associated with no side effects, and may become an alternative to the IBD treatment".

Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention and treatment of Crohn's disease (CD), pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Comparison of remicade to curcumin for the treatment of Crohn's disease: A systematic review by Schneider A1, Hossain I1, VanderMolen J2, Nicol K. (PubMed)
(2) Curcuminoids from Curcuma Longa: New adjuvants for the treatment of crohn's disease and ulcerative colitis? by Cunha Neto F1, Marton LT1, de Marqui SV1, Lima TA1, Barbalho SM. (PubMed)
(3) Geographical variation of Crohn's disease residual incidence in the Province of Quebec, Canada by Pascal Michel,1,2 Laurie St-Onge,1 Anne-Marie Lowe,3 Michel Bigras-Poulin,2 andPaul Brassard. (PMC)

Herbal Bilberry, A Natural Treatment for Peyronie's disease

By Kyle J. Norton


Peyronie's disease is a rare condition caused by plaque, that forms inside the penis, leading to a bent erect penis, depending on where the plaque is located.

Patients with Peyronie's disease has been found to affect sexual desire due to a physical condition associated with painful sexual intercourse and erectile dysfunction.

Researchers do not know the exact causes of Peyronie's disease. However, according to the epidemiological studies, researchers suggested that injury that causes bleeding inside the penis may induce the built-up of scars, particularly in men with the genetic preposition of certain genes.

Most cases of pain in Peyronie’s disease are mild and often do not require treatment, however, over counter medicine may be needed occasionally.

Believe or not, most mild cases of men with Peyronie's disease do not require treatment as the condition has been found to go away within a year. In severe cases, surgery may be necessary to remove the scar tissues in the penis that cause the condition.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Researchers on finding a natural compound for the treatment of Peyronie's disease investigated various antioxidants, including bilberry in PD treatment with significantly increase the likelihood of therapeutic success.

By comparing the effects of silymarin, ginkgo biloba, vitamin E, bilberry, topical diclofenac sodium, and pentoxifylline (PTX) in patients with PD, researchers found that by administration of a single oral antioxidant; two oral antioxidants; three oral antioxidants; five oral antioxidants + local diclofenac; and five oral antioxidants + local diclofenac + PTX achieve better results when combining more than one agent.

According to the tested assays, the combination of more than a single compound reduced the symptoms in patients with PD, including the improvement and disappearance of penile pain; percentage of reduction in the volume of penile plaque; reduction in penile curvature; recovery of erectile function in patients with erectile dysfunction; increase in the International Index of Erectile Function score; and reduction of psychosexual impact.

Particularly, treatment of combined therapy including oral treatment with more than one antioxidant is greater when topical use of diclofenac gel and perilesional injection of PTX, compared to those of single conventional medicine.

In other words, combined natural or dietary antioxidants such as bilberry into the diet of patients with PD are more effective in inhibiting the symptoms compared to the use alone of any single ingredient therapy.

The final outcome of 6 months of treatment showed that combined antioxidant therapy is effective in treating PD. 

Dr. Paulis G, the lead scientist, after taking other factors into account wrote in the final report, " Although several articles have already been published reporting the effectiveness of combined treatment in PD, this is the first study clearly proving how, as the number of substances used in treatment rises, a proportionally greater therapeutic effect is achieved."

Taken altogether, bilberry combined with other antioxidants or conventional medicines may be considered function remedies for the treatment of Peyronie's disease (PD), pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Rationale of combination therapy with antioxidants in medical management of Peyronie's disease: results of clinical application by Paulis G1,2, Paulis A3, Romano G4, Barletta D5, Fabiani A. (PubMed)

Herbal Turmeric Optimizes the Intestinal Mucosal Barrier Function Against Pathogens

By Kyle J. Norton


Intestinal mucosa processes a single cell layer of epithelial cells with a function to protect the intestine against invasive pathogens and ensure the function of intestinal in nutrients adsorption.

Biologically, the intestinal protection of the intestinal mucosal barrier function is associated with
*Bile and gastric acid produced the liver and stomach that only aid digestion but kills microorganism

* Defensins secretory epithelial cells with a function to protect the intestines against bacteria, fungi and many enveloped and nonenveloped viruses.

* Lysozyme is an enzyme that protects the intestine by causing the destruction of the cell walls of certain bacterias.

* Regenerating islet-derived protein 3 gammas (Reg3γ), an antibacterial lectin is a type of antimicrobial peptides found in the gut epithelial Paneth cells with a function to prevent microorganisms from coming into contact with the epithelial layer.

In other words, the intestinal mucosal barrier plays an essential role in the separation of the inside of the body from the outside environment, particularly in harmful microorganisms.

Dr. Oshima T the lead scientist in the examination of light junctions (TJs), the most important component for the construction of a constitutive barrier of epithelial cells that regulates the permeability of the barrier by tightly sealing the cell-cell junctions, wrote, "Gastrointestinal diseases including reflux esophagitis, inflammatory bowel disease, functional gastrointestinal disorders, and cancers may be regulated by these molecules, and disruption of their functions leads to chronic inflammatory conditions and chronic or progressive disease".

And, "regulation of the barrier function of epithelial cells by regulating the expression and localization of TJ proteins is a potential new target for the treatment of these diseases".

More precisely, by improving the intestinal mucosal barrier function, diseases associated with the gastrointestinal tract may be preventable.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a potential ingredient for the protection of the intestinal mucosal barrier, researchers examined the effects of curcumin extensive pharmacological effects, on gastrointestinal diseases.

According to the analysis, curcumin exerted protective effects of the intestinal mucosal barrier through multiple pathways.

More precisely, curcumin protected the tissues of the intestinal mucosal barrier by

* By reducing the production of proinflammatory cytokines in orchestrating cell damage.

* By inhibiting the oxidative stress caused by overexpression of free radicals in facilitating the onset of chronic inflammation in the initiation of intestinal mucosal damage.

* By reducing levels of bacteria in the induction of infection that may weaken the function of the intestinal mucosal barrier.

Moreover, curcumin also protected the cells of intestinal mucosa against apoptosis.

Additional differentiation of the tested assays, researchers also found that curcumin also balances the ratio of gut microbiota associated with the regulation of intestinal microecology and intestinal immune response which plays a critical role in enhancing the intestinal mucosal barrier function.

Taken altogether, turmeric may be considered supplements for the improvement of intestinal mucosal barrier function, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [Advances in the research of protective effect of curcumin on intestinal mucosalbarrier function].
[Article in Chinese; Abstract available in Chinese from the publisher] by He D1, Wang S2, Hu H2, Yin HY2. (PubMed)
(2) Gastrointestinal mucosal barrier function and diseases by Oshima T1, Miwa H. (PubMed)

Phytochemical Alliin Gobbles Up Plagues Against the Onset of Atherosclerosis

By Kyle J. Norton

Atherosclerosis is a medical condition induced arterial narrowing due to the accumulation of plague that weakens the arterial wall.

Atherosclerosis is the most common cause of heart disease and stroke in the Western world, depending on the location of oxygenated rich blood flow blockage.

Plague is made up of fat, cholesterol, calcium, and other substances in the blood.

According to the epidemiological studies, diseases associated with atherosclerosis include coronary heart disease (plaque in arteries in or leading to the heart), angina (chest pain from reduced blood flow to the heart muscle), carotid artery disease (plaque in neck arteries supplying blood to the brain),  and peripheral artery disease (plaque in arteries of the extremities, especially the legs).

According to the statistics provided by the CDC, coronary heart disease (CHD)  caused by atherosclerosis is the most common type of heart disease, that kills over 370,000 people annually.

Every year about 735,000 Americans has a heart attack. Of these, 525,000 are a first heart attack and 210,000 happen in people who have already had a heart attack

Although there are many risk factors that increase the risk of plaque accumulation, some researchers suggested people who follow the high-fat diet without injection of an adequate amount of fruits and vegetables are at a higher risk of atherosclerosis.

Dr. Zhao Y, the lead scientist in the team of cardiovascular disease at the Chinese PLA General Hospital wrote, "Coronary artery disease has a significant genetic predisposition, which mainly results from atherosclerosis".

And, "(Pig fed with high-fat diet) At 6 months, plaque lesions appeared in the abdominal aorta and iliac artery, while at 8 months, they appeared in the coronary artery. At 12 months, atherosclerotic lesions could be found in all major arteries, while lipid core, cholesterol precipitation, and calcium deposition appeared in the most serious sites".

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

With an aim to find potential treatment for atherosclerosis, a leading cause of cardiovascular disease, researchers evaluated the capacity of Allium ursinum (wild garlic) leaf lyophilisate (WGLL; alliin content: 0.261%) to mitigate cardiovascular damage in hypercholesterolemic rabbits.

Selected tested New Zealand rabbits incldued in the study were divided into three groups: (i) cholesterol-free rabbit chow (control); (ii) rabbit chow containing 2% cholesterol (hypercholesterolemic, HC); (iii) rabbit chow containing 2% cholesterol + 2% WGLL (hypercholesterolemic treated, HCT); for eight weeks.

According to the differentiation at the zero- and eight-week time points, WGLL treatment protects the cardio functioning by mediating the increase in fractional shortening, right ventricular function; peak systolic velocity; tricuspid annular systolic velocity in live animals.

Furthermore, WGLL improved aortic and coronary flow.

In other words,  WGLL exerted cardiovascular protective activity by promoting the function of ventricles in blood circulation via regulating the blood pressure.

Moreover, according to the Western blot analysis, revealed WGLL-associated increases in HO-1 protein associated with reduced cardio oxidative stress and decreases in SOD-1 protein involved oxygen metabolism.

Interestingly, WGLL also expressed a significant decrease in aortic atherosclerotic plaque coverage, plasma ApoB, an important component of many lipoproteins involved in atherosclerosis and cardiovascular disease. and the activity of LDH and CK (creatine kinase) in plasma.

Particularly, the chemical compound also inhibited the plasma LDL.

Based on the findings, researchers wrote in the final report, "The results clearly demonstrate that WGLL has complex cardioprotective effects, suggesting future strategies for its use in prevention and therapy for atherosclerotic disorders".

Taken altogether, alliin may be considered supplements for the prevention and treatment of atherosclerosis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-Atherogenic Properties of Allium ursinum Liophylisate: Impact on Lipoprotein Homeostasis and Cardiac Biomarkers in Hypercholesterolemic Rabbits by Bombicz M1,2, Priksz D3,4, Varga B5,6, Gesztelyi R7, Kertesz A8, Lengyel P9, Balogh P10, Csupor D11, Hohmann J12, Bhattoa HP13, Haines DD14, Juhasz B. (PubMed)
(2)  Atherosclerosis Induced by a High-Cholesterol and High-Fat Diet in the Inbred Strain of the Wuzhishan Miniature Pig by Zhao Y1, Xiang L1, Liu Y1, Niu M1, Yuan J1, Chen H. (PubMed)

Phytochemical Lycopene Inhibits Cancer Metastasis in Vitro and Vivo

By Kyle J. Norton

Cancer is a class of disease associated with irregular cell growth on the tissue of the specific organ.

Most cases of invasive cancer can spread to other organs in the body via lymph or blood.

According to the statistics provided by the Cancer Institue, between n 2011–2015, the number of new cases of cancer is 439.2 per 100,000 men and women per year (based on 2011–2015 cases). 

The number of cancer deaths (cancer mortality) is 163.5 per 100,000 men and women per year.

Under normal circumstance, cell growth is a natural process without even notice, every day millions of cell grow to replace millions of dead cells and to keep our body in balance and healthy.

Sometimes, acceleration of cells growth is necessary to prevent further damage to the body organ, such as cut, injure, etc., but after fulfilling their purposes, the growth of cells are back to a normal rate again due to our body growth inhibitors. Unfortunately, skin cells sometimes overgrow while healing, leading to scar to the skin.

In cancer cells, due to the alternation of DNA, can grow indefinitely. 

Cancer cell metastasis is the process that cancer cells break away from the primary site and travel through the blood or fluid circulation and form new tumors (metastatic tumors) in other parts of the body, similar to those of primary cancer.

Dr. RUI-AN WANG, the lead scientist in the explanation of the reasons for cancer metastasis, wrote, "Over several years, scientists investigating cancer have focused their efforts on elucidating the mechanisms underlying cancer metastasis, with the aim of finding a way to inhibit this process".

And, "Cancer metastasizes due to several factors, namely attack by the immune system, lack of oxygen and necessary nutrients, large amounts of lactic acid produced by glycolysis and increased cell death. Therefore, the majority of the presently available treatments for cancer also bear the potential to induce metastasis".

In other words, for the tumor to survive that must metastasize.

Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.

In the urgency to find a natural ingredient for the inhibition of cancer cell metastasis, researchers examined the apo-10'-lycopenoic acid (ALA), a derivative of lycopene through cleavage by carotene-9',10'-oxygenase, on tumor progression and metastasis in both liver and lung cancer animal models.

According to the tested assays, ALA showed significant activity in a dose-dependent manner in inhibiting migration and invasion of liver and lung cancer cells (HuH7 and A549).

In other words, ALA constrained lung cancer cell from the induction of mechanisms associated with cancer cell spreading.

Furthermore, in HuH7 and immortalized lung BEAS-2B cells, ALA suppressing the function of remodeling actin in stimulating cancer cell mobility and membrane formation.

More importantly, ALA also inhibited both HuH7 and A549 cells. proliferation and migration by suppressing the genes associated with angiogenesis.

Moreover, according to the tested assays, ALA also decreased the expression of enzyme which plays a pivotal role in cell migration during physiological and pathological processes.

In human THE-2 liver cells, ALA in a dose-dependently increased the mRNA expression and protein levels of peroxisome proliferator‑activated receptor‑γ (PPARγ) involved in controlling angiogenesis, tumor progression and metastasis.

Based on the findings, Dr. Cheng J., the lead scientist wrote, "ALA inhibits cancer cell motility and angiogenesis and induces PPARγ expression, which could be one of the potential mechanisms for ALA protecting against tumor progression".

Taken altogether, phytochemical lycopene may be considered supplements for the prevention of cancer cell metastasis, pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Peroxisome proliferator-activated receptor-γ inhibits pancreatic cancer cell invasion and metastasis via regulating MMP-2 expression through PTEN by Li Y1, Zhang DW1, Lin DQ1, Cao LQ1. (PubMed)
(1) Apo-10'-lycopenoic acid inhibits cancer cell migration and angiogenesis and induces peroxisome proliferator-activated receptor γ by Cheng J1, Miao B1, Hu KQ1, Fu X1, Wang XD. (PubMed)
(3) Reasons for cancer metastasis: A holistic perspective by RUI-AN WANG,1,2,3 YOU-YONG LU,4 and DAI-MING FAN (PubMed)