Ginger, the Natural Treatment for Endometriosis, with no Side Effects

By Kyle J. Norton

Endometriosis is a condition caused by endometrial tissues which grow somewhere in the body instead of in the endometrium. Most cases of endometriosis are in the organs in the pelvic area, including ovaries and fallopian tubes.

Endometriosis also reacts to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through the menstrual period.

According to the statistics provided by the Clinical Center of Niš,

* About 20% of reproductive age women with endometriosis are assymptomatic

* About 55% of women have developed the new onset of severe menstrual cramps

* About 25% of women with sub-fertility (less fertile than a normal couple), depending on the stages of endometriosis.

Endometriosis can be classified into 4 stages
* Minimal stage
The top surface, few in number. Commonly they are found in the inside wall of uterus, ligaments, and ovary, causing a significant reduction in both progesterone and its ratio with 17 beta-oestradiol, luteal dysfunction and abnormal secretory patterns(3). Minimal stage endometriosis may lead to unexplained causes of infertility(2).

* Mild stage
Deeper implants, greater numbers are presented. Commonly found in the same area as a minimal stage, causing worsening of oocyte quality. Mild stage of endometriosis may lead to infertility(4).

* Moderate stage:
Many implants, endometrial cysts are presented, affecting ovary function, and causing scar tissues and adhesion.

* Severe stage:
Intensive peritoneal implants, large endometriomas are presented with dense adhesion.

Conventionally, most cases of endometriosis are treated by pain medicines such as NSAIDs (non-steroidal anti-inflammatory drugs) and hormone therapy such as birth control pills with an aim to reduce pain and improve quality of life, including daily activity.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers in the urgency to find natural compounds for the treatment of endometriosis with no side effects evaluated the efficacy and safety of acupuncture-moxibustion combined with modified Mojie tablet containing ginger in the prevention of the recurrence of endometriosis (EMS) after laparoscopic surgery.

The study included 120 cases of EMS after laparoscopic surgery, randomly assigned into an acupuncture-moxibustion group, a western medication group, a Chinese medication group and a combined therapy of acupuncture-moxibustion and Chinese medication group (combined therapy group).

Each group containing 30 participants was separated, before treatment, after treatment, in 3 months after treatment and in 6 months after treatment.

In the acupuncture-moxibustion group, acupuncture was applied at Xuehai (SP 10), Sanyinjiao (SP 6) and Guanyuan (CV 4); the isolated moxibustion with ginger was used at Guanyuan (CV 4), once a day, twice a week.

In the western medication group, gestrinone was prescribed for oral administration, 2.5 mg, once a day, twice a week.

In the Chinese medication group, the self-prepared Mojie tablet was prescribed for oral administration.

And, in the combined therapy group, acupuncture, moxibustion and modified Mojie tablet for oral administration were used in combination.

In 3 and 6 months after treatment, the positive rates of EHP-5 score were 0% (0/30) in the combined therapy group and 0% (0/30) in the acupuncture-moxibustion group, compared to the lower significantly than 13.3% (4/30) in the western medication group.

In follow-up stage of 6 months after treatment, according to the abdominal ultrasound examination, there was no recurrence case in the combined therapy group, compared to the lower than 13.3% (4/30) in the western medication group.

According to assays, the serum CA125 detection in the combined therapy group did not find any abnormal case, compared to the lower than 16.7% (5/30) in the western medication group (P < 0.05).

Based on the results, researchers wrote in the final report, "Acupuncture and moxibustion combined with modified Mojie tablet effectively prevent the recurrence of EMS after laparoscopic surgery and improve the life quality of the patients".

Take all together, ginger may be used combined with other traditional medicine and therapies for the prevention and treatment of endometriosis and recurrent endometriosis, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) [Efficacy observation on the combination of acupuncture and Chinese medication in prevention of the recurrence of endometriosis after laparoscopic surgery] [Article in Chinese] by Zhang XY, Zhang CY. (PubMed)
(2) Mid to late luteal phase steroids in minimal stage endometriosis and unexplained infertility.
Barry-Kinsella C1, Sharma SC, Cottell E, Harrison RF(PubMed)
(3) Cyclical gonadotrophin and progesterone secretion in women with minimal endometriosis by Williams CA, Oak MK, Elstein M.(PubMed)
(4) Follicular fluid from infertile women with mild endometriosis may compromise the meiotic spindles of bovine metaphase II oocytes by Da Broi MG1, Malvezzi H, Paz CC, Ferriani RA, Navarro PA(PubMed)

Herbal Turmeric Inhibits the Onset and Progression of Chronic Prostatitis

By Kyle J. Norton

Prostatitis is a condition associated with the inflammation of the prostate and the areas around the prostate.

According to the statistics provided by the American Family Physician, approximately 8.2 percent of men in the US are living with prostatitis. The conditions account for 8 percent of visits to urologists, and up to 1 percent of visits to primary care physicians.

Believe it or not, in 2000, prostatitis has cost over $84 million, including the charge of diagnosis and treatment.

Most common symptoms of prostatitis are painful, difficult and/or frequent urinating, groin pain, rectal pain, abdominal pain and/or low back pain, fever, chills, and body aches.

In severe cases, patients may also experience symptoms of urethral discharge, painful ejaculation or sexual dysfunction and blood in the urine.

The exact causes of prostatitis are not identified, some researchers suggested that nerve damage in the lower urinary tract caused by surgery or trauma to the area has been found to induce prostatitis in patients.

Conventionally, most cases of prostatitis are treated by antibiotics in cases of infection, alpha blockers to relax the bladder neck and the muscle fibers and anti-inflammatory medicine to ease pain and discomforts.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a potential and natural ingredient for the treatment of inflammatory diseases such as chronic prostatitis/ chronic pelvic pain syndrome type III (CP/CPPS), researchers examined the effect of turmeric on chronic bacterial prostatitis.

The phase II, the randomized, single-blinded, placebo-controlled clinical trial included 60 patients who were examined by University of Catania from June 2015 to January 2016 we enrolled 60 consecutive due to CP/CPPS III.

At the end of the experiment, the treatment group showed a significant improvement of National Institutes of Health Chronic Prostatitis Symptom Index, IIEF-5 (+ 3.5; p &lt; 0.01), particularly other symptomatic parameters compared to placebo.

Participants were then allocated to receive treatment (Group A) or placebo(Group B). Treatment consisted of rectal suppositories of Curcumin extract 350 mg (95%) and Calendula extracts 80 mg (1 suppository/die for 1 month). Patients of Group B received 1 suppository/die for 1 month of placebo. 

The efficacy of the treatment with Curcumin and Calendula was associated with the reduction of inflammatory cytokines and of inflammatory cells.

Based on the findings, Dr. Morgia G, the lead researcher said, "In this phase II clinical trial, we showed the clinical efficacy of the treatment with Curcumin and Calendula in patients with CP/CPPS III".

Taken altogether, turmeric used alone or combined with Calendula may be considered supplements for the prevention and treatment of chronic bacterial prostatitis and chronic pelvic pain syndrome, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A phase II, randomized, single-blinded, placebo-controlled clinical trial on the efficacy of Curcumina and Calendula suppositories for the treatment of patients with chronic prostatitis/chronic pelvic pain syndrome type III by Morgia G1, Russo GI, Urzì D, Privitera S, Castelli T, Favilla V, Cimino S. (PubMed)
(2) Therapeutic roles of curcumin: lessons learned from clinical trials by Gupta SC1, Patchva S, Aggarwal BB. (PubMed)

Whole Food Tomato Normalizes Hepatic Markers Against Liver Damage and Injury

By Kyle J. Norton

Hepatic marker is a blood test that measures the function of the liver. In other words, according to the blood test results, your doctor may know the severity of the liver damage.

The liver is the largest internal organ in the body which plays a critical role to filter out blood from the digestive system before passing them to other parts of the body.

Furthermore, the liver also produces bile which has a strong impact on the building of cell membranes, production of steroid hormones and vitamin D and aiding the digestive system in the absorption of nutrients.

Liver transaminases aspartate transaminase (AST) and alanine transaminase (ALT) are some of the liver markers used by researchers to measure liver injury in a patient with some degree of intact liver function.

Aspartate transaminase (AST)  is an enzyme found primarily in the liver and kidney. High levels of ALT is associated with liver damage. ALT screening is used often in patients with
liver disease.

Alanine aminotransferase (ALT) is a liver enzyme. increased levels of ALT has been found in patients with liver damage.

Other liver enzymes such as Alkaline phosphatase (ALP) and Gamma-glutamyl transpeptidase (GGT) also have a similar effect as seen in ALT and AST.

More precisely, elevated liver enzymes is an indication of liver inflammation or cell damage.

Dr. Edoardo G. Giannin, the lead scientist in the explanation of liver enzymes alternation, wrote, "Abnormal liver enzyme levels may signal liver damage or alteration in bile flow. Liver enzyme alteration may be either the accompanying biochemical picture in a patient with symptoms or signs suggestive of liver disease or an isolated, unexpected finding in a patient who has undergone a wide range of laboratory tests for a nonhepatic disease or for minor, vague complaints".

And, "The pattern of enzyme abnormality, interpreted in the context of the patient's characteristics, can aid in directing the subsequent diagnostic work-up. Awareness of the prevalence of the determined liver disease in specific populations and of possible hepatic involvement during systemic illnesses or drug therapies may help the clinician identify the cause of alterations efficiently".

The results strongly suggested that testing hepatic markers of patients with liver disease may be helpful to identify the causes.

Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

In the urgency to discover healthy foods which process liver protective effects, researchers examined the effect of dry tomato peel (DTP) on hepatic markers on a high-saturated-fat (HSF) diet animal model for 12 weeks.

The study included 40 8 weeks old, weighing 22.2±1.0 g) BALB/c male mice (n=40) divided into four treatment groups (10 mice/group): (a) high-fat control diet (HF Ctrl), which contains sunflower oil as a sole source of fat; (b) HSF/high-cholesterol (HC) diet; (c) HSF/HC diet supplemented with 9% DTP and (d) HSF/HC diet supplemented with 17% DTP.

According to the tested assays, without supplement with DTP, HSF/HC diet treated mice showed significantly increased body weight gain, adipose tissue weight, insulin resistance and lipid peroxidation in the liver as well as the onset of liver steatosis and inflammation.

Upon the injection of DTP,  HSF/HC diet mice demonstrated a significant increase in plasma lycopene concentration and reduced markers associated with metabolic syndrome developing.

In other words, DTP inhibited the liver damage and injury marker through its anti-inflammatory and antioxidant activity and lipid metabolism

Taken altogether, tomato processed a high amount of lycopene may be considered a dietary supplements for liver protection, pending to large sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of dry tomato peel supplementation on glucose tolerance, insulin resistance, and hepatic markers in mice fed high-saturated-fat/high-cholesterol diets by Zidani S1, Benakmoum A2, Ammouche A3, Benali Y4, Bouhadef A4, Abbeddou S. (PubMed)
(2) Feeding tomato and broccoli powders enriched with bioactives improves bioactivity markers in rats by Liu AG1, Volker SE, Jeffery EH, Erdman JW Jr. (PubMed)
(3) Liver enzyme alteration: a guide for clinicians by Edoardo G. Giannini, Roberto Testa, and Vincenzo Savarino. (PMC)

Bromelain Suppresses Rheumatoid Arthritis in Vivo

By Kyle J. Norton

Rheumatoid Arthritis (RA) a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body.

The disease affects more women than men and generally occurs after the ages of 40, causing the diminished quality of life of many elders(1). 

According to CDC, Musculoskeletal disorders (MSDs) affects over 52 millions of adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions(2). 

Rheumatoid Arthritis can induce bone loss through elevating bone resorption without increasing bone formation(4). A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes(4a).

Most common symptoms of RA are
* The feet and joints
Patient with rheumatoid arthritis (RA) often associates with valgus deformities of the feet and gait due to body function in an effort to support the collapsing longitudinal arch of the foot.

* The gait
Rheumatoid arthritis (RA) causes a significant reduction in joint motions, joint moments, such as decreased hip flexion-extension range, hip abduction, knee flexion-extension range.

* The hands
The effects of deformation of RA's hands can be described through the defects of bone ankylosis as a result of bone damage to the prolonged onset of the disease(12).

* The Muscle strength
The effects of muscle strength in a patient with RA may contribute to the prevalence of functional limitations physically of that can affect daily living and quality of life.

* Rheumatoid Nodules
Rheumatoid nodules, lump on the skin, closed to the joint have been found to affect the joints of patients with rheumatoid nodules.

* Conjunctival nodule
Although is rare in patients with rheumatoid arthritis, the appearance of the nodules may exhibit the

the severity of the underlying disease.

* Morning stiffness
Morning stiffness, as a marker of inflammatory activity that reflects the functional disability and pain is a very common symptom of patients in early rheumatoid arthritis.

Conventionally, there is no cure for RA. Medication is to relieve symptoms such as pain, slow the progression and improve quality of life, including disease-modifying antirheumatic drugs (DMARDs) and nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a natural agent for the treatment of adjuvant rheumatic diseases, researchers examined the anti-inflammatory property of both enzyme therapy and combined therapy with cyclosporin in an animal model.

The study included rats with adjuvant-induced arthritis administered either cyclosporin A (2.5 or 5.0 mg/kg/day per os), a mixture of enzymes (Phlogenzym (PHL); 45 mg/kg twice daily intrarectally), or a combination of 2.5 mg cyclosporin A and 90 mg PHL for a period of 40 days.

According to the tested assays, the combination therapy with cyclosporin A plus PHLshowed a significantly inhibited both the inflammation and destructive arthritis-associated changes, such as serum albumin, changes in hind paw swelling and bone erosions.

Compared to the higher dose, 2.5 mg of cyclosporin A and PHL alone inhibited the disease markers to a lesser extent and a later stage of arthritis development.

In other words, the combination inhibited all parameters associated with the onset of adjuvant rheumatic diseases in a dose-dependent manner.

Based on the findings, researchers wrote, "The results show the inhibitory effect of enzyme therapy on rat adjuvant arthritis, as well as the efficacy of a low dose of cyclosporin A given in combination with enzyme therapy, which may be useful in the treatment of rheumatoid arthritis".

Taken altogether, bromelain used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of adjuvant rheumatic diseases, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [Proteolytic enzymes as an alternative in comparison with nonsteroidal anti-inflammatory drugs (NSAID) in the treatment of degenerative and inflammatory rheumatic disease: systematic review].
[Article in German] by Heyll U1, Münnich U, Senger V. (PubMed)
(2) Enzyme and combination therapy with cyclosporin A in the rat developing adjuvant arthritis by Rovenská E1, Svík K, Stancíková M, Rovenský J. (PubMed)
(3) Most Common Disease of elder: The Clinical Trials and Studies of musculoskeletal disorders(MSDs) - Rheumatoid Arthritis: The Signs and Symptoms by Kyle J. Norton

Phytochemical Alliin Strengthens the Gut immunity

By Kyle J. Norton

Gastrointestinal tract microbiome is the community of microorganisms containing micro-organisms including mostly bacterias and some viruses, fungi, and protozoa.

Under normal conditions, the ratio of good and bad microbiomes are balanced.

Believe it or not, our GI-tract harbors one of the most complex and abundant ecosystems colonized by more than 100 trillion microorganisms, including Firmicutes and Bacteroidetes.

Believe it or not, compared to only 23 000 genes in the human genome, the microbiome encodes over three million genes producing thousands of metabolites, which play a critical role in many of the functions of our body.

Dr. Veronica Lazar, the lead scientist in the examined the interaction of gut microbiome and the immune system suggested that

* Gut microbiome has a strong impact to modulate neutrophil migration and function that affects the differentiation of T cell populations into different types of helper cells (Th), respectively.

* Gut microbiome interaction also can trigger antimicrobial responses by stimulating the production of the sIgA production, the first line of defense against pathogens and toxins.

* Gut microbiome interacts with the immune system against the initiation and progression of infectious diseases.

* Balanced gut microbiome protects the intestinal immune responsiveness that associates with the onset of autoimmune and inflammatory diseases, inclduing cancer.

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

On findings a potential compound for the improvement of gut microbiota, researchers examined the diet of traditional Asian is similar to the Mediterranean rich of quercetin and alliin on the growth of host and the status of the gut microbiota and colonic epithelial immunity.

According to the tested assays, the alternate consumption of quercetin and alliin significantly increased the rat body weight and reshaped the gut microbiota composition.

In other words, the intake of quercetin and alliin improved the ratio of gut microbiota by enhancing the levels of good bacteria in the colon.

More precisely, quercetin and alliin increased the relative abundance of fecal Firmicutes and Cyanobacteria but decreased that of Bacteroidetes (P < 0.05) and increased the relative abundance of Candidatus Arthromitus, Lactococcus, Geobacillus, and Ruminococcus.

Furthermore, genes linked to gut immunity with higher-level systemic functions of cells, the organism, and the ecosystem were also altered in the rat fed with quercetin and alliin.

The results strongly suggested that the diet of traditional Asian is similar to the Mediterranean that not only promotes gut health but also enhanced gut immunity.

Based on the findings, researchers wrote, "the alternate consumption of quercetin and alliin in traditional Asian diet can contribute beneficial metabolic effects by optimizing gut microbiota and altering the immunologic function of colonic epithelial cells".

Taken altogether, alliin used alone or combined with another phytochemical may be considered supplements for the improvement of the gut immunity, pending on the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The Alternate Consumption of Quercetin and Alliin in the Traditional Asian Diet Reshaped Microbiota and Altered Gene Expression of Colonic Epithelial Cells in Rats by Yu J1, Guo H1, Xie J1, Luo J1, Li Y1, Liu L1, Ou S1, Zhang G1, Peng X. (PubMed)
(2) Aspects of Gut Microbiota and Immune System Interactions in Infectious Diseases, Immunopathology, and Cancer
Veronica Lazar1,2†, Lia-Mara Ditu1,2, Gratiela Gradisteanu Pircalabioru1,2†, Irina Gheorghe1,2, Carmen Curutiu1,2, Alina Maria Holban1,2, Ariana Picu1,3, Laura Petcu1,3 and Mariana Carmen Chifiriuc1. (Frontier in Immunology)

HerbaLTurmeric Blocks the Onset of Oral Mucositis Caused By the Bacterial Infection

By Kyle J. Norton

Oral mucositis is considered a side effect in patients who undergo cancer treatment, particularly chemotherapy and radiation.

In cancer, oral mucositis is caused by the reduced function of the immune system to protect the infection of open sores in the mucosa.

However, poor oral or dental health, smoking or chewing tobacco and drinking alcohol, female gender, dehydration and patients who had previously cancer treatment, have kidney disease are some of the most common risk factors that cause the onset of oral mucositis.

Most common symptoms of oral mucositis are red, shiny, or swollen mouth and gums, sores in the mouth or on the gums or tongue,  pain in the mouth or throat, mild burning, or pain when eating food.

Some patients may also experience symptoms of difficulty swallowing or talking, soft, whitish patches or pus in the mouth or on the tongue, particularly the increase of mucus or thicker saliva in the mouth.

Some researchers suggested the onset of oral mucositis in most cases are associated with people with a weakened immune system, including the use of chemotherapy.

Dr. Francesco Chiappelli wrote, "Mucositis is observed in a variety of immunosuppressed patients, but is most often consequential to cancer therapy. It appears as early as the third day of the intervention, and is usually established by Day 7 of treatment".

And, "The precise immune components involved in the etiology of mucositis are unclear, but evidence-based research (EBR) data has shown that applications of granulocyte–macrophage-colony stimulating factor prevent the onset of the exacerbation of oropharyngeal mucositis".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a potential compound for the treatment of oral mucositis(OM), researchers evaluated the effects of turmeric and curcumin in the management of oral mucositis in cancer patients undergoing chemo and/or radiotherapy by searching the database of Cochrane Library, LILACS, LIVIVO, PubMed, Scopus, and Web of Science.

After a two-step selection process, four randomized and one nonrandomized clinical trials were included in the analysis in which 2 studies suggested that topical application of turmeric/curcumin as a gel or mouthwash showed a reduced grade of mucositis, pain, erythema intensity, and ulcerative area.

In other words, the topical application of turmeric or curcumin may be effective in controlling signs and symptoms of oral mucositis in tested patients.

Furthermore, according to the study of 72 golden Syrian hamsters induced mucositis (OM) by 5-fluorouracil (5-FU) for 4 days randomly allocated into four groups: control, placebo, chamomilla, and a mucoadhesive formulation containing curcuminoid (MFC)
* On day 5, all groups exhibited OM

* On day 8, both MFC and chamomilla groups exhibited better-wound healing compared to other groups.

* Moreover, also on day 8, the MFC group demonstrated inhibited protein associated with stimulating new blood vessel for the OM to grow and proinflammatory cytokines to facilitate symptoms of OM, compared to placebo and control group.

Collectively, Dr. Schmidt TR, the lead scientist wrote in the final report, "these findings suggest that MFC has a therapeutic effect on OM, accelerating wound healing through re-epithelization and anti-inflammatory action as modulation of angiogenesis and TGF-β1 expression".

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of OM, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of turmeric and curcumin on oral mucositis: A systematic review by Normando AGC1, de Menêses AG2, de Toledo IP1,3, Borges GÁ1, de Lima CL1, Dos Reis PED2, Guerra ENS. (PubMed).
(2) Mucoadhesive formulation containing Curcuma longa L. reduces oral mucositisinduced by 5-fluorouracil in hamsters by Schmidt TR1, Curra M1, Wagner VP1, Martins MAT1,2, de Oliveira AC3, Batista AC4, Valadares MC5, Marreto RN3, Martins MD. (PubMed)
(3) The Molecular Immunology of Mucositis: Implications for Evidence-Based Research in Alternative and Complementary Palliative Treatments by Francesco Chiappelli. (PMC)

Phytochemical Betanin Normalizes Your High Blood Pressure

By Kyle J. Norton

Hypertension is a medical condition caused by abnormally high pressure that presses against the wall of the arteries, affecting the heart function in pumping blood to the body.

Hypertension is a member of the cluster of metabolic syndrome that facilitates the risk of cardiovascular disease and types 2 diabetes

Epidemiologically, uncontrolled high blood pressure has been found to induce the risk of heart attack and stroke.

Most patients with high blood pressure are asymptomatic. However, the long-term elevated force of the blood against your artery walls may result in symptoms of headache, dizziness, and shortness of breath, early signs of heart disease and stroke.

According to the statistics provided by the CDC, approximately 75 million American adults (32%) have high blood pressure. In other words, 1 in every 3 American adults is affected by high blood pressure.

Believe it or not, the actual numbers of high blood pressure are substantially higher if people with the stage of prehypertension are also taking into account.

Sadly, only half of the people with high blood pressure in the US are under control.

There are 2 types of hypertension, including primary hypertension that takes years to develop and secondary hypertension associated with other medical conditions, such as kidney and thyroid disease.

Out of many prevalent factors, some researchers suggested that the promotion of a high-fat diet over the past few decades may have a direct implication on the onset of hypertension in American adults.

Dr.Dixon W. Wilde, the lead scientist wrote, "Dietary fat contributes to the elevation of blood pressure and increases the risk of stroke and coronary artery disease".

And, "an elevation of plasma FAs may contribute to the development of hypertension via a process involving the elevation of Ca2+ current density and alteration of channel kinetics in the vascular smooth muscle membrane".

The results strongly suggested the high-fat diet induced elevated FAs associated with the alternation of vascular smooth muscle membrane in the initiation of hypertension.

Betanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains, found abundantly in beets, chard, etc.

On finding a potential ingredient for the treatment of hypertension, researchers examined the effect of betanin against a hypertensive animal model.

The study included animals divided into six main groups with each group containing 5 animals.

* Group I received the vehicle,

* Group II received dexamethasone injection (20 µg/kg/day, s.c.) for 14 days,

* Group III received an extract of Beta vulgaris (100 mg/kg/day, p.o.) for 14 days,

* Group IV received an extract of Beta vulgaris (300 mg/kg/day, p.o.) for 14 days,

* Group V received dexamethasone injection (20 ugs/kg/day, s.c.) and extract of Beta vulgaris (100 mg/kg/day, p.o.) for 14 days and

* Group VI received dexamethasone (DEXA) injection (20 µg/kg/day, s.c.) and extract of Beta vulgaris (300 mg/kg/day, p.o.) for 14 days.

At the end of the experiment after 14 days, the group treated with a combination of dexamethasone and beta vulgaris (100 and 300 mg/kg p.o. for 14 days) showed a significant decrease in heart rate compared to Dexamethasone group.

According to the tested assays, Dexamethasone treated group showed a significant elevation (p<0.05) in systolic blood pressure (SBP), vascular reactivity changes to Catecholamine, compared to the control group. 

Injection of beta vulgaris extract (100, 300 mg/kg/day, p.o.) for 14 days in dexamethasone administered rats significantly (p<0.05) demonstrated a significant reversal of such change.

Based on the finding, researchers wrote, "The methanolic-HCl extract of Beta vulgaris has antihypertensive activity in Dexamethasone models".

In other words, betanin detected by phytochemical analysis from beta vulgaris extract protected the heart function and blood vessels through its antihypertensive properties.

Taken altogether, betanin may be considered supplements for the prevention and treatment of hypertension, pending to the confirmation of larger sample size and multicenter human study.

Intake of betanin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antihypertensive activity of Beta vulgaris on dexamethasone-induced hypertension in rats by Dignesh Patel, Rupali A Patil, and Alkesh Patel. (Research Gate)
(2) High-Fat Diet Elevates Blood Pressure and Cerebrovascular Muscle Ca2+Current
Dixon W. Wilde, Kenneth D. Massey, Glenn K. Walker, Alan Vollmer, and Roger J. Grekin. (Hypertension)