Bromelain Protects the tissues On Chronic Wound Healing

By Kyle J. Norton

A chronic wound is a wound that does not heal within a predictable period of time.

It may be a result of the interruption of the stage of wound healing or damage of the blood vessels that have a function in providing necessary conditions to promote the closure of the wound as seen in a diabetic leg ulcer.

In other words, any wound that does not heal with 3 months is considered a chronic wound.

According to the statistics provided by the study "An Economic Evaluation of the Impact, Cost, and Medicare Policy Implications of Chronic Nonhealing Wounds", approximately, 2% of the population in developed countries suffer from chronic wounds. 

Additionally, every year, more than 305 million cases of acute, traumatic and burn wounds are treated globally. 

Believe it or not,  chronic and acute wound affects more than nine times of people around the world compared to those living with cancer.

Some researchers suggested that pressure, trauma and/or lower extremity wounds, increased the bacterial load, interruption of the stage of wound healing including excessive proteases, degraded cell surface structures, and inappropriate treatment are considered the most potential causes of the conditions.

More precisely, if we can protect all stages of wound healing without interruption, the chronic wound can be preventable.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent for the treatment of pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a natural compound for the treatment of the chronic wound, researchers examined the efficacy of bromelain-based enzymatic debridement of chronic wounds.

The study included 24 patients with chronic wounds of different aetiologies.

According to 2 consecutive single-arm studies assessing the enzymatic debridement efficacy in 2 medical centers, all wounds achieved an average of 68% ± 30% debridement in an average of 3.5 ± 2.8 enzymatic debridement 4-hour sessions.

17/24 patients showed the responding wounds (venous, diabetic, pressure, and post-traumatic aetiologies) of an average of 85% ± 12% debridement in 3.2 ± 2.5 applications, compared to 7/24 patients with no response.

There were no adverse effects reported by the patients. Based on the findings, researchers wrote, "These preliminary results indicate the potential safety and efficacy of bromelain-based enzymatic debridement in chronic wounds".

In vitro, according to the results of two soft tissue healing--fibroblasts and microvascular endothelial cells--were used as mono- and co-culture with bromelain, bromelain attenuated endothelial cell and fibroblast proliferation moderately.

The inhibition of cell proliferation was not associated with cell apoptosis but cell cycle arrest in the G0 phase.

In the comparable tested, bromelain did not reduce endothelial cell migration. whereas fibroblast migration was clearly slowed down.

In other words, bromelain displayed a significant decrease of myofibroblasts under both normoxic (from 19 to 12 %) and hypoxic conditions (from 22 to 15 %) coincident with higher levels of anti-inflammatory expression.

Based on the findings, researchers wrote, "Usage of bromelain as a therapeutic drug for chronic human wounds thus remains a very promising concept for the future".

Taken altogether, bromelain used alone or combined with other remedies may be considered supplements for the prevention and treatment of chronic wounds, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Bromelain-based enzymatic debridement of chronic wounds: A preliminary report by Shoham Y1, Krieger Y1, Tamir E2, Silberstein E1, Bogdanov-Berezovsky A1, Haik J3, Rosenberg L. (PubMed)
(2) Bromelain down-regulates myofibroblast differentiation in an in vitro wound healing assay by Aichele K1, Bubel M, Deubel G, Pohlemann T, Oberringer M. (PubMed)

Phytochemical Alliin, the Best Free Radical Scavenger Against the Onset of Oxidative Stress

By Kyle J. Norton

Free radical scavengers are antioxidants that inhibit free radicals before they can cause damage to the tissues and organs.

Free radicals are unstable and high reactive atoms with a single electron in the outermost ring. Therefore, in order to maintain stable, free radicals are ready to steal or donate a single electron from other stable atoms in the body, leading to a cascade that cannot be stopped until all single electron is paired or inhibited by antioxidants.

In the body, free radical is produced by cell metabolism that provides energy for body needs. Outside of the body, free radicals can be anywhere including the air we breathe and the foods we eat.

In other words, any chemical compound containing oxygen atoms can be free radicals during the process of a chemical reaction.

Most common types of free radical scavengers include

* Bilirubin
Bilirubin is a prosthetic group which breaks down molecules into smaller units to release energy, excrete them through bile and urine. 

* Carotenoids
Carotenoids are organic pigments, occurring in the chloroplasts and chromoplasts of plants and some other photosynthetic organisms like algae, some bacteria.

* Flavonoids
Flavonoids neutralize many of reactive oxygen species (ROS), including singlet oxygen, hydroxyl, and superoxide radicals.

* Thiols (R-SH)
Chemically, thiol, an organosulfur compound have strong odors resembling that of garlic plays an important in the functioning of enzyme regulation, control of gene expression, protein trafficking, and receptor signaling.

* Coenzyme Q10
Coenzyme Q10 enhances energy production by promoting the process of the production of ATP then serving as fuel for the cells and acts an antioxidant to prevent the generation of free radicals during this process.

* Vitamin A, C, E. D.
**Vitamin A
Vitamin A plays an important role that scavenges free radicals in the lining of the mouth and lungs. The vitamin also boosts the immune system in controlling free radicals, preventing oxidation of LDL and enhances the productions of insulin pancreas.

** Vitamin C
Vitamin C, an antioxidant and water soluble vitamin, vitamin C can be easily carried in the blood, The vitamin not only restores the vitamin E but also fights against the forming of free radicals.

** Vitamin E
Vitamin E not only protects muscle weakness, repairs damaged tissues, lowers blood pressure and induce blood clotting in healing wound, but also moves into the fatty medium to prevent lipid peroxidation.

** Vitamin D
 vitamin D, a group of fat-soluble secosteroids is also a membrane antioxidant with the ability to inhibit iron-dependent lipid peroxidation in liposomes compared to cholesterol.

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

On finding a natural compound for the treatment of diseases associated with oxidative stress, researchers examined the alliin ability to inhibit osteoclast differentiation and fusion on osteoporosis.

According to the results of the experiment, alliin showed significant effects in improvement of bone density in osteoporotic patients by inhibiting receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast fusion and differentiation.in bone resorption by blocking the signaling pathway activation.

Additional differentiation of the alliin osteoporosis protective activity, researchers found that alliin decreased the generation of reactive oxygen species (ROS) by inhibiting the expression enzyme involved in the generation of free radicals.

In other words, alliin protects the bone density by decreasing the bone reabsorption and oxidative stress in the bone tissues.

Based on the findings, researchers wrote, "The overall results revealed that alliin could be a potential therapeutic agent in the treatment of osteoporosis".

Taken altogether, alliin may be considered supplements as a free radical scavenger against the onset of oxidative stress, pending on the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Alliin Attenuated RANKL-Induced Osteoclastogenesis by Scavenging Reactive Oxygen Species through Inhibiting Nox by Chen Y1,2, Sun J3, Dou C4, Li N5, Kang F6, Wang Y7, Cao Z8, Yang X9, Dong S. (PubMed)
(2) Comparative studies of bioactive organosulphur compounds and antioxidantactivities in garlic (Allium sativum L.), elephant garlic (Allium ampeloprasum L.) and onion (Allium cepa L.) by Kim S1, Kim DB1, Jin W1, Park J1, Yoon W1, Lee Y1, Kim S1, Lee S1, Kim S1, Lee OH2, Shin D1, Yoo M. (PubMed)

Herbal Turmeric Protects the Endocrine Function Naturally

By Kyle J. Norton

Scientists may have found a bioactive ingredient which protects the endocrine system integrity with no side effects, according to studies.

The endocrine system is made up of glands that produce and secrete hormones with an aim to regulate the activity of cells or organs.

In other words, the endocrine system produces hormones to regulate the body's growth, metabolism (the physical and chemical processes of the body), and sexual development and function.

Any disruption of the endocrine system can cause abnormal production of the hormones, leading to developmental malformations in the infant and children, interference with the function of the reproductive organ, increased cancer risk; and disturbances in the immune and nervous system function.

The most common cause of endocrine dysfunction is exposure to men-make xenochemiclas. Particularly to those new and without testing men make chemicals introduced to the market every year.

There are many ways that endocrine disruptors can interfere with the endocrine system in hormone production such as mimic or partly mimic naturally occurring hormones in the body like estrogens such as xanophytochemicals that bind to a receptor within a cell and block the endogenous hormone from binding.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a natural ingredient which promotes the endocrine function, researchers examined the effects of ginger and turmeric on the modulation of hormone production of the body glands.

According to the differentiation of physiological and therapeutic effects of ginger and turmeric, both exerted a significant activity in some endocrine gland functions, and signal pathways by 

* Inhibiting the high levels of some hormones such as T4, leptin or interacting with hormone receptors. In other words, ginger and turmeric normalize the levels of the hormone for the body needs.

* Inhibiting the production of cytokines/adipokine expression associated with inflammation and oxidative stress.

* Inhibiting the levels of reactive oxygen species (ROS)-generating enzymes against the oxidative stress induced hormone imbalance.

* Protecting the cell integrity against DNA alternation by promoting pro-apoptotic and inhibiting proliferative genes.

The results strongly suggested that ginger and curcumin exerted strong protection of endocrine functioning by modulating the hormones produced by the glands.

Based on the findings, researchers said, "These multiple mechanisms of protection against inflammation and oxidative damage make ginger and curcumin particularly promising natural agents in fighting the ravages of aging and degenerative diseases".

Taken altogether, turmeric combined with ginger may be considered supplements for the prevention and treatment of endocrine dysfunction, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Physiological and therapeutical roles of ginger and turmeric on endocrine functions by Al-Suhaimi EA1, Al-Riziza NA, Al-Essa RA. (PubMed)
(2) [Effect of 5 warm-hot nature Chinese drugs for promoting blood circulation and removing blood stasis on 5-HT, NE, and endocrine hormones of rats of cold coagulation and blood stasis syndrome].[Article in Chinese] by Wang P1, Fu XJ, Zhou Y, Wang ZG. (PubMed)

3,3'-Diindolylmethane Suppresses the Progression of Non-alcoholic Steatohepatitis (NASH)

By Kyle J. Norton


Non-alcoholic steatohepatitis (NASH) is an advanced form of inflammatory non-alcoholic fatty liver disease (NAFLD) caused by a buildup of fat in the liver.

NASH has been found to induce the formation of scars of the liver, a leading cause of cirrhosis associated with the onset of liver cancer and liver failure.

The progression of NASH has been a leading cause of liver transplant.

Patients with NASH are asymptomatic. However, some patients may experience vague pain and discomfort in the abdomen.

The causes of NAFLD are identified. Some researchers suspected that long-term unhealthy diet accompanied by physical inactivity may have a strong impact in accelerating the onset of the disease.

Dr. Kristen Stephenson in the investigation of the western diet in the risk NAFLD, wrote, "Nonalcoholic fatty liver disease (NAFLD) is a disease of increasing interest, as its prevalence is on the rise. NAFLD has been linked to metabolic syndrome, which is becoming more common due to the Western diet".

And, "WD mouse models consisting of high fat, cholesterol, and a combination of high-fructose corn syrup, sucrose, fructose, or glucose not only lead to metabolic syndrome but also induce NAFLD".

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

On finding the natural ingredient for the treatment of nonalcoholic steatohepatitis (NASH), researchers at the joint investigation led by the Fudan University examined the effects of 3, 3'-diindolylmethane (DIM) on methionine-choline-deficient (MCD)-diet induced mouse nonalcoholic steatohepatitis (NASH).

NASH mice were administrated with or without DIM at different concentrations for 8 weeks 

In vivo, DIM treatment alleviated hepatic steatosis and inflammation and restored the Treg/Th17 imbalance from MCD diet-induced Th17 dominance to Treg dominance.

In-vitro, instead of suppressing the expression of Th17m, DIM not only significantly promoted the expression of the mRNAs that purify spleen CD4(+) T cells, but also enhanced the immunosuppressive function of these Treg cells.

In MCD-diet mice, DIM significantly exhibited the function of CYP1A1 and CYP1B1 in metabolizing liver toxicity, whereas down-regulated those of TLR4 on CD4(+) T cells in the promotion of autoimmune inflammation, leading to Treg/Th17 imbalance.

In other words, DIM treated NASH by dramatical induction of Treg dominance to alleviate intra-hepatic inflammation.

Dr. Liu Y, the lead scientist wrote, "dietary cruciferous vegetables (containing abundant DIM) might exist as a protective factor for patients with NASH-related liver diseases".

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of nonalcoholic steatohepatitis (NASH), pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3, 3'-Diindolylmethane alleviates steatosis and the progression of NASH partly through shifting the imbalance of Treg/Th17 cells to Treg dominance by Liu Y1, She W1, Wang F1, Li J2, Wang J1, Jiang W. (PubMed)
(2) Updates on Dietary Models of Nonalcoholic Fatty Liver Disease: Current Studies and Insights by Kristen Stephenson,* 1 Lindsey Kennedy,†‡ 1 Laura Hargrove,‡ Jennifer Demieville,†Joanne Thomson,† Gianfranco Alpini,*†‡ and Heather Francis. (PMC)

Herbal Bilberry Improves Your Lipoprotein Parameters in Human Trials

By Kyle J. Norton

The lipoprotein profiles or lipoprotein parameters are a general term comprised the traditional lipoprotein profile include total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and triglyceride.

Total cholesterol is the total amount of cholesterol in your blood, including the low-density lipoprotein (LDL, or “bad”) cholesterol and high-density lipoprotein (HDL, or “good”) cholesterol. 

The healthy ratio of blood cholesterol is less than 4 of the low-density lipoprotein to 1 of high-density lipoprotein.

Where low-density lipoprotein is produced by the liver or from food sources needed for the cells to build strong membranes, produce steroid hormones, vitamin D and bile to aid the digestive system in absorbing nutrients and fluids.

And high-density lipoprotein produced by the liver or from the external sources needed to return the low-density lipoprotein back to the liver.

Triglycerides, an important measure of heart health is the fat in the blood caused by the over-consumption of foods containing fat, carbohydrates, and simple sugars.

Factors that affect your lipoprotein profiles can be unpreventable including age, gender, race, and genetic preposition and preventable such as diet, weight, physical activity, and smoking.

Some researchers suggested that people who are obese are at a substantially higher risk of poor lipoprotein profiles.

Dr. Pandolfi C, the lead scientist wrote, "Lipid pattern has resulted in overlapping both in the two studied populations and in the two subgroups of pre- and postmenopausal women, while greater concentrations of Lp(a), (p < 0.001) and t-PA (p < 0.05) have been found in obese populations vs controls".

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belongings to the family Ericaceae, native to Northern Europe.

The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

In the urgency on finding natural sources of the plant-based compound for the prevention of cardiovascular disease (CVD), researchers investigated regular consumption of bilberries in CVD risk reduction.

Women (n=25) and men (n=11) selected to the study received 150 g of frozen stored bilberries 3 times a week for 6 weeks. All parameters associated with the risk CVD were measured by standard assays.

In both sexes, the consumption of bilberries led to a decrease in the parameters of lipoprotein profiles, including total cholesterol, LDL-C, TG, and a positive increase in HDL-C.

However, in men, additionally, favorable changes were observed in total cholesterol (P=.004), reduced oxidative stress and HDL-C, but increase in LDL-C compared to women group.

In other words, the regular intake of bilberries can be important to reduce CVD risk, by promoting a decrease of  LDL-C/TG and increase of HDL-C.

Furthermore, in order to reveal more information about bilberry against CVD risk, researchers compared consumed dried sea buckthorn berries (SBs), sea buckthorn oil (SBo), sea buckthorn phenolics ethanol extract mixed with maltodextrin (SBe+MD, 1:1), or frozen bilberries on metabolic profiles.

In a total of 80 women selected to complete this randomized crossover study for 30 d, all interventions induced a significant effect on the overall metabolic profiles, particularly in lipid parameters observed both in participants who had a metabolic profile that reflected higher cardiometabolic risk at baseline (group B) and in participants who had a lower-risk profile (group A).

However, bilberries treatment group caused beneficial changes in serum lipids and lipoproteins in group B, whereas the opposite was true in group A.

The finding clearly suggested bilberries modulated the parameters of lipids and lipoproteins depending on the risk of CVD.

Dr. Larmo PS, after taking into account of co and confounders wrote, "Berry intake has overall metabolic effects, which depend on the cardiometabolic risk profile at baseline (including bilberry)".

Taken altogether, bilberry may be considered a functional remedy for the promotion of lipid-protein profiles in reducing the risk of CVD, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Intake of bilberries (Vaccinium myrtillus L.) reduced risk factors for cardiovasculardisease by inducing favorable changes in lipoprotein profiles by Habanova M1, Saraiva JA2, Haban M3, Schwarzova M4, Chlebo P5, Predna L6, Gažo J7, Wyka J. (PubMed)
(2) Effects of sea buckthorn and bilberry on serum metabolites differ according to baseline metabolic profiles in overweight women: a randomized crossover trial by Larmo PS1, Kangas AJ, Soininen P, Lehtonen HM, Suomela JP, Yang B, Viikari J, Ala-Korpela M, Kallio HP. (PubMed)
(3) [Lipoprotein(a), parameters of lipid metabolism and hemostasis in obese patients].[Article in Italian] by Pandolfi C1, Pellegrini L, Dedè A, Lo Vecchio M, Mercantini F. (PubMed)

Phytochemical Betalains, the Anti-Lipid Oxidation Bioactive Compound

By Kyle J. Norton

Lipid oxidation is a condition of oxidative lipid generation.

In other words, the molecule in the lipid has an unpaired electron in the outer ring.

Free radicals are unstable atoms which have an unpaired electron in the outer most ring. In order to become stable, they must donate or intercept an electron from other stable atoms, leading to a chain reaction that can not be stopped until all electrons in the outer ring are paired or inhibited by antioxidants.

Overexpression of free radicals caused by depletion of antioxidant enzymes produced by the host body has been found epidemiologically inducing protein and lipid damage and alternation of cell DNA in facilitating the risk of chronic diseases.

In the examined the pathology of neurological disorders, some researchers suggested that lipid oxidation in the brain may induce neurological disease due to the vulnerability of the central nervous system for reactive oxygen species-mediated injury.

Precisely, the risk of neuro damaged by lipid oxidation is greatest in the brain because the neurons consume large amounts of oxygen, areas containing high iron content, and neuronal mitochondria generate large amounts of hydrogen peroxide, particularly the neuronal membranes are rich in polyunsaturated fatty acids.

Out of many risk factors that induced lipid oxidation in the body, some researchers suggested that the promotion of a high-fat diet over the past few decades may be one of the major cause of diseases associated with the condition.

Dr. Schrauwen P, the lead scientist wrote, " Twenty-four-hour fat oxidation gradually increased on the high-fat diet. Both at rest and during exercise, there was no change in the rate of appearance of fatty acids and plasma-derived fatty acid oxidation. Triglyceride-derived fatty acid oxidation tended to be higher after 7 days of high-fat diet at rest (P < 0.07)".

And, "the results from this study suggest that triglyceride-derived fatty acid oxidation (VLDL or intramuscular triglycerides) plays a role in the increase in fat oxidation on a high-fat diet, but plasma-derived fatty acids remain the major source for fat oxidation".

The findings strongly suggested people with the weakened immune system and low levels of antioxidant due to aging is vulnerable to lipid oxidation induced neuro-degenerative disease.

Betanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to find a potential ingredient against hyperlipidemia, researchers evaluated the bioavailability of betalains from dietary sources.

The study included 8 healthy volunteers (n = 8) with a single ingestion of 500 g cactus pear fruit pulp, which provided 28 and 16 mg indicaxanthin and betalain, respectively.

According to the first-order kinetics, betanin and indicaxanthin reached their maximum plasma concentrations 3 h after the fruit meal and declined and disappeared from plasma by 12 h after intake.

Thes results suggested that betalain are biologically unstable.

Betalains at concentrations of 100.5 +/- 11 and 50 +/- 7.2 pmol/mg showed a significant effect in protecting the LDL protein against oxidation.

Compared to the samples isolated before fruit ingestion, the higher amounts of betalains showed the higher the resistance against injury caused by lipid oxidation.

In other words, the higher amount of betalains in the blood demonstrated higher protection against tissues damage due to oxidative stress.

Based on the findings, Dr. the lead scientist wrote in the final report, "cactus pear fruit is a source of bioavailable betalains and suggests that indicaxanthin and betanin may be involved in the observed protection of LDL against ex vivo-induced oxidative modifications".

Taken altogether, betanin may be considered supplements for the prevention and treatment of tissues damage caused by lipid oxidation, pending to the confirmation of larger sample size and multicenter human study.


Intake of betalains in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Absorption, excretion, and distribution of dietary antioxidant betalains in LDLs: potential health effects of betalains in humans by Tesoriere L1, Allegra M, Butera D, Livrea MA. (PubMed)
(2) The role of lipid peroxidation in neurological disorders by Mototada Shichiri. (PMC)
(3) Increase in fat oxidation on a high-fat diet is accompanied by an increase in triglyceride-derived fatty acid oxidation by Schrauwen P1, Wagenmakers AJ, van Marken Lichtenbelt WD, Saris WH, Westerterp KR. (PubMed)

Herbal Ginger, A Potent Remedy for the Treatment Alzheimer's disease (AD) in Vivo

By Kyle J. Norton

Scientists may have found a natural aal ingredient used in every kitchen for the treatment of Alzheimer's disease (AD), according to studies.

Alzheimer's disease is a progressive disease caused the gradual loss of the neurons in the affected area.

People with AD  experience of symptoms of memory, thinking, and behavior severe enough to affect language communication, memory, lifelong hobbies or social life. The severity of symptoms is totally depending on the stage of the disease.

Without proper treatment, Alzheimer's disease can get worse over time, and it is fatal.

According to the statistic, over 1 million people in the US alone are currently afflicted by Alzheimer's disease caused by the generation of the hippocampus and cerebral cortex of the brain where memory, language, and cognition located.

With this mental disorder, brain cells gradually die and generate fewer and fewer chemical signals day by day, leading to diminished functions.

As of today, there is no known cure. Most treatment is to interfere with the progression and improve the quality of the disease in people in the early stage.

Although there are many risk factor associated with the disease onset. However, in the examination of the median age of patients diagnosed with AD. Some researchers suggested that the increase in age may be one of the major risk factors that cause Alzheimer's disease.

Dr. Raymond Y. Lo, said, "Alzheimer's disease (AD) has become a global health issue as the population ages. There is no effective treatment to protect against its occurrence or progression. Some argue that the lack of treatment response is due to delays in diagnosis. By the time a diagnosis of AD is made, neurodegenerative changes are at the stage where very few neurons can be salvaged by medication".

And, " The paradigm of dementia care policy may shift to early diagnosis of AD pathology and comprehensive care for chronic diseases in the elderly population".

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding a natural compound for the treatment of Alzheimer's disease (AD) with no side effects investigated the methanolic extract of dry ginger (GE) anti AD through the antioxidant activity, cholinesterase inhibition, anti-amyloidogenic potential, and neuroprotective properties.

The extracts used for the study included18 +/- 0.6 mg/g gallic acid equivalents of total phenolic content and 4.18 +/- 0.69 mg quercetin equivalents/g of dry material.

GE expressed high antioxidant activity with an IC50 value of 70 +/- 0.304 microg/mL, through reducing the expression of neuro oxidative stress in the initiation of AD.

According to the Ellman's assay, GE had an IC50 value of 41 +/- 1.2 microg/mL and 52 +/- 2 microg/mL for inhibition of acetyl- and butyrylcholinesterase association with the formation of β-amyloid (Aβ) plaques, respectively.

Also, GE increased the cell survival against amyloid beta (Abeta) induced toxicity in primary adult rat hippocampal cell culture.

Furthermore, GE effectively prevented the formation of Abeta oligomers and dissociated the preformed oligomers.

Based on the results, Dr. Mathew M, the lead scientist said, "Methanolic GE influences multiple therapeutic molecular targets of AD".

In order to provide more information about the ginger anti incidence of AD, researchers assessed the ability of a traditional Chinese medicinal ginger root extract (GRE) to prevent behavioral dysfunction in the Alzheimer disease (AD) rat model.

Rat AD models used for the study were treated with a one-time intra-cerebroventricular injection of amyloid β-protein (Aβ) and continuous gavage of aluminum chloride every day for 4 weeks before GRE was administered intragastrically.

At day 35, The significant memory deficits were shorter in the group that received OP with a high dose of GRE (HG)(OP+HG) than in the groups that received OP with a low or moderate dose of GRE (LG, MG)(OP+LG, OP+MG).

High dose of GRE (HG)(OP+HG) injection also increased the expression of antioxidant enzymes produced by the host such as superoxide dismutase (SOD) and catalase (CAT) compared to the OP+HG groups (p<0.05).

Also, rat treated high dose of GRE (HG)(OP+HG) also showed reduced levels of pro-inflammatory cytokines and oxidative stress marker.

Dr. Zeng GF, the lead scientist wrote in the final report, "This experiment demonstrates that the administration of GRE reverses behavioral dysfunction and prevents AD-like symptoms in our rat model".

Take all together, ginger processed a high amount of bioactive compounds may be considered a function alternative for the prevention and treatment of AD, pending to the confirmation of large sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) In vitro evaluation of anti-Alzheimer effects of dry ginger (Zingiber officinale Roscoe) extract by Mathew M, Subramanian S. (PubMed)
(1) Protective effects of ginger root extract on Alzheimer disease-induced behavioral dysfunction in rats by Zeng GF1, Zhang ZY, Lu L, Xiao DQ, Zong SH, He JM. (PubMed)
(3) The borderland between normal aging and dementia by Raymond Y. Lo. (PMC)