Herbal Bilberry Processed Anti Alzheimer's disease Potency in Vitro and Vivo

By Kyle J. Norton


Alzheimer's disease is a chronic neurodegenerative disease caused by the gradual loss of neuron functioning that usually starts with the early symptom of the difficulty of remembering recent events and worsens over time.

The disease is most prevalent in the elderly and causes over 60% of all cases of dementia.

According to the statistics, approximately 5.7 million Americans of all ages have Alzheimer's. 15.9 million family caregivers provided an estimated 18.2 billion hours and $230 billion to people with dementia worldwide.

Epidemiological studies suggested that Alzheimer's disease is caused by a combination of genetic, lifestyle and environmental factors that affect the neurons of the brain over time.

Although, less 10% of patients with AD are associated with a genetic preposition. Patients with such a mutated gene are virtually guaranteed to develop the disease.

More precisely, any one of a number of different single-gene mutations on chromosomes 21, 14, and 1 was found to induce the onset of AD.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Researchers on finding a natural compound for the treatment of Alzheimer's disease (AD) investigated the effects of anthocyanoside extracts (Vaccinium myrtillus anthocyanoside (VMA)) obtained from bilberry on the in vitro progression of Aβ fibril formation and in vivo effects of this compound on AD pathogenesis.

In Neuro2a cells, injection of VMA inhibited the in vitro formation of Aβ peptide fibrils in the induction of neurons toxicity.

Furthermore, A diet containing 1% VMA prevented the cognitive degeneration was found in the tested AD mice. 

Interestingly, this diet in the retention of cognitive ability was not accompanied by a reduction in the aggregate deposition in brains but rather, an increase in insoluble deposits, compared to control mice. 

The results suggested that VMA shows a strong effect on Alzheimer's disease by altering the Aβ aggregation to a non-toxic form.

In order to reveal more information about bilberry anti AD activity, researchers elucidated the effects of different polyphenols on neuroprotection and APP processing under different in vitro stress conditions.

Injection of myricetin, quercetin or anthocyanin-rich extracts in a dose-dependent manner significantly inhibited the overexpression of free radicals caused by the application of Menadione.

APdE9 mice fed with anthocyanin-rich bilberry or blackcurrant extracts showed decreased APP C-terminal fragment levels, the amyloid precursor protein in the cerebral cortex, compared to APdE9 mice on the control diet.

Levels of soluble Aβ40 and Aβ42 levels were found to significantly decrease in bilberry-fed mice, compared to blackcurrant-fed mice.

Additionally, bilberry diet also improved the spatial working memory of aged APdE9 mice, compared to mice on the control diet. 

Based on the findings, Dr. Vepsäläinen S, the lead scientist wrote in the final report, "These data suggest that anthocyanin-rich bilberry and blackcurrant diets favorably modulate APP processing and alleviate behavioral abnormalities in a mouse model of AD".

Taken altogether, bilberry rich of anthocyanin may be considered a functional remedy for the prevention and treatment of Alzheimer's disease (AD), pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Anthocyanin suppresses the toxicity of Aβ deposits through diversion of molecular forms in vitro and in vivo models of Alzheimer's disease by Yamakawa MY, Uchino K, Watanabe Y, Adachi T, Nakanishi M, Ichino H, Hongo K, Mizobata T, Kobayashi S, Nakashima K, Kawata Y. (PubMed)
(2) Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease by Vepsäläinen S1, Koivisto H, Pekkarinen E, Mäkinen P, Dobson G, McDougall GJ, Stewart D, Haapasalo A, Karjalainen RO, Tanila H, Hiltunen M. (PubMed)

Phytochemical Alliin, Inhibits Parameters Associated with the Onset of Diabetes in Vivo

By Kyle J. Norton

Diabetes is a chronic and medical condition associated with insufficiency of insulin in the bloodstream. In other words, it is the condition as a result of the body can not use insulin properly or produce enough insulin.

The condition is either caused by beta cells of pancreas died-off or insulin receptor site clogged-up by fat or cholesterol.

Type I diabetes is a genetic preposition involved the abnormal function of the immune system which mistakenly destroys the beta cells in the pancreas.

Most common symptoms of diabetes are  associated with abnormally high blood sugar, leading to symptoms of unusual thirst frequent urination, weight change (gain or loss), extreme fatigue or lack of energy

In serious cases, untreated hyperglycemia in some patients may also cause symptoms of blurred vision or recurring infections due to cuts and bruises and erectile dysfunction.

According to the statistics provided by the World Health Organization, worldwide, the numbers of people with diabetes have risen at an alarming rate from 108 million in 1980 to 422 million in 2014.

The global prevalence of diabetes has reached  8.5%  among adults over 18 years of age in 2014, compared to only 4.7% in 1980.

Most common risk factors associated with the onset of diabetes in the US are family history, ethnicity, gender, insulin resistance, gestation diabetes, obesity, impaired glucose tolerance, women with PCOs and aging.

However, some researchers in the concern of the rise of diabetes over the past few decades accompanied by the widespread obesity in the US suggested that the promotion of the Western diet may have a strong effect in the induction of the condition in a population with a higher genetic risk score (GRS) 

Dr. Lu Qi,, the lead scientist wrote, "A widely held hypothesis is that interactions between genetic predisposition and Western-type lifestyle contribute to the epidemic of type 2 diabetes (T2D)".

And, "intakes of processed meat, red meat, and heme iron, which characterized the Western dietary pattern, showed significant interactions with GRS in relation to diabetes risk (P for interaction = 0.029, 0.02, and 0.0004, respectively). The diet-diabetes associations were more evident among men with a high GRS (≥12) than in those with a low GRS".

In other words, if you have a high GRS accompanied by Western diet, your risk type II diabetes is substantially higher compared to those who have a low GRS.

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

With an aim to find potential and natural compound for the treatment of diabetes, researchers evaluated the preventive effect of alliin against metabolic risk factors an animal model.

The study included diet-induced obese (DIO) mice treated with drinking water with or without alliin (0.1 mg/ml) for 8 weeks. 

According to the tested assays, alliin had no significant effect on the body weight, adiposity or energy balance, however, alliin treated group showed enhanced glucose homeostasis, increased insulin sensitivity and improved the lipid profile compared to control.

Further analysis of the results, researchers found that the efficacy of alliin was attributed to the modulation of the intestinal microbiota composition, typically decreased Lachnospiraceae and increased Ruminococcaceae.

Based on the findings, researchers said, "alliin has nutraceutical or even medicinal potential in the prevention of diabetes and lipid metabolic disorders".

Furthermore, in the normal and alloxan-induced diabetic rats for five weeks, researchers compared the production and therapeutic efficiency of alliin extracted from garlic leaves of plants grown under ex-situ and in situ conditions.

According to the tested assays, serum glucose, triglycerides, total lipids, total cholesterol, low-density lipoprotein (LDL)-, and very low-density lipoprotein (VLDL)-cholesterol in diabetic rats treated with alliin produced from in situ grown plants noted significant reduction of ~54%, 15%, 14%, 20%, 24%, and 15%, while 35%, 14%, 10%, 12%, 17%, and 11% reduction was noted in diabetic rats treated with alliin without affecting the levels of high-density lipoprotein (HDL)-cholesterol compared to other groups.

Leaf extract of plants also restored the normal levels of serum enzyme levels of alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase which were elevated in diabetes rats.

Taken altogether, alliin may be considered a supplement for the prevention and treatment of diabetes, pending to the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Hypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice by Zhai B1, Zhang C1, Sheng Y1, Zhao C2, He X1,3, Xu W1,3, Huang K1,3, Luo Y. (PubMed)
(2) Alliin obtained from leaf extract of garlic grown under in situ conditions possess higher therapeutic potency as analyzed in alloxan-induced diabetic rats by Nasim SA1, Dhir B, Kapoor R, Fatima S, Mahmooduzzafar, Mujib A. (PubMed)
(3) Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men by Lu Qi, Marilyn C Cornelis, Cuilin Zhang, Rob M van Dam, and Frank B Hu. (PMC)

Betanin, the Potential Anti Liver Cancer Bioactive Compound

By Kyle J. Norton

Liver cancer is a medical and chronic condition characterized by uncontrollable and disordered cell growth in the liver tissues.

Most cases of liver cancer is a result of liver cell DNA altercation started in the cell on the surface of the inner lining of the tissue of the liver.

At the early stage, most patients with primary liver cancer are asymptomatic due to the small size of tumor.

According to the epidemiological studies, at the advanced stage, liver cancer can lead to secondary metastasis by spreading to breast, colon, bladder, kidney, ovary, pancreas, stomach, uterus, and lungs through the circulation of fluids and blood.

The American Cancer Society's in the estimation of the primary liver cancer and intrahepatic bile duct cancer in the United States for 2019 wrote, "About 42,030 new cases (29,480 in men and 12,550 in women) will be diagnosed. About 31,780 people (21,600 men and 10,180 women) will die of these cancers".

The exact causes of liver cancer are not identified. However, worldwide, the most common risk factor for liver cancer is chronic (long-term) infection with hepatitis B virus (HBV) or hepatitis C virus (HCV). 

However, some researchers suggested compared to other hepatitis infection, the hepatitis C virus (HCV) infection is one of the major causes of liver cancer.

Dr. Luis Jesuino de Oliveria Andrade, the lead scientist wrote, " Hepatocellular carcinoma (HCC) is the fifth most common cancer, the third most common cause for cancer death in the world, a major cause of death in patients with chronic hepatitis C virus infection, and responsible for approximately one million deaths each year".

And, " Overwhelming lines of epidemiological evidence have indicated that persistent infection with hepatitis C virus (HCV) is a major risk for the development of HCC. The incidence of HCC is expected to increase in the next two decades, largely due to hepatitis C infection and secondary cirrhosis, and detection of HCC at an early stage is critical for a favorable clinical outcome". 

In other words, if you are HCV carrier, your risk of liver cancer increased substantially compared to people who are not.

Betanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to find a natural compound for the treatment of liver cancer, researchers examined the extract of Beta vulgaris (beetroot), commercially also known as betanin chemopreventive potentials in three different chemical carcinogen initiation-promotion experimental tumor models in mice.

In the two-stage model of liver cancer in mice induced by  N-nitrosodiethylamine (DEN, 30 mg/kg) as the initiator and phenobarbital as the promoter, researchers found that oral administration of 0.0025% betanin showed significant inhibition of both the incidence and multiplicity of the liver tumors.

In other words, betanin inhibited the initiation and proliferation of liver cancer cells.

Surprisingly, betanin processed a strong cancer chemopreventive effect a very low dose, compared to other herbal and phytochemical medicine.

By comparing to both in vitro Epstein-Barr early antigen activation assay and in an in vivo two-stage mouse lung and skin carcinogenesis, Dr. the leads scientist said, "These findings along with our initial reports suggest that betanin which is a regularly consumed natural product colorant is an effective cancer chemopreventive agent in mice".

Taken altogether, betanin may be considered supplements for the prevention and treatment of liver cancer, pending to the confirmation of larger sample size and multicenter human study.

Intake of betanin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot by Kapadia GJ1, Azuine MA, Sridhar R, Okuda Y, Tsuruta A, Ichiishi E, Mukainake T, Takasaki M, Konoshima T, Nishino H, Tokuda H. (PubMed)
(2) Association Between Hepatitis C and Hepatocellular Carcinoma by Luis Jesuino de Oliveria Andrade, Argemiro D'Oliveira, Junior, Rosangela Carvalho Melo,1Emmanuel Conrado De Souza,1 Carolina Alves Costa Silva, and Raymundo Paraná. (PMC)

Ginger' 6-Gingerol Processes Anti-Female Infertility Activity With No Side Effects, Scientists Say

By Kyle J. Norton

On seeking natural therapy with no side effects, scientists may have a veggie for the protection of the reproductive organs, according to studies.

In women, the reproductive organs are the vagina, uterus, fallopian tubes and ovaries. The reproductive system works together to produce the female egg cells, transporting them to the fallopian tube where fertilization by a sperm may occur.

In men, the reproductive organs are the testicles. the duct system, which is made up of the epididymis and the vas deferens and the accessory glands, which include the seminal vesicles and prostate gland.

The reproductive system in men plays a critical role in producing, maintaining, and transporting healthy sperms and semen.

Infertility is a condition characterized by the failure to achieve a clinical pregnancy, including the inability of the woman to carry the pregnancy to full term, after 12 months or more of regular unprotected sexual intercourse.

Some researchers suggested that obese women may have the negative implication of getting pregnant and maintaining pregnancy.

Dr. Moran LJ, the lead scientist at the University of Adelaide in the concern of obese effect on the reproductive system wrote, "Overweight and obesity are significant and increasing health problems associated with increased risks of morbidity, quality of life, and metabolic and reproductive health consequences"

And, "In women, being overweight or obese is associated with impaired fertility and decreased the chance of conception both in natural and assisted reproductive technology births. During pregnancy, overweight and obesity are associated with increased risk of adverse maternal and infant health outcomes".

The results strongly suggested that healthy weight women are associated with a lower risk of infertility and adverse maternal and infant health outcome.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding a natural ingredient for the treatment of infertility examined the effects of 6-gingerol on the biochemical parameters and ovarian histological improvements in estradiol valerate (EV) induced polycystic ovary syndrome (PCOS) rats.

The 6 female Wistar rats selected to the study were divided randomly into 4 groups:
* Control were given a normal diet,

* PCOS control, were given4 mg/kg EV injection for 28 days and

* The two experimental groups, were given an EV injection for 28 days and followed by 6-gingerol (200 μg/kg and 400 μg/kg) for 14 days.

Without an injection of 6-gingerol, EV application showed an increase in body and ovarian weights, abnormality in serum sex steroid profile.

Furthermore, EV application also expressed a decreased antioxidant activity and increased production of proinflammatory cytokines associated with the expression of the protein Cyclooxygenase (COX)-2.

6-gingerol treatments, particularly the 400 μg/kg dose, markedly attenuated all these alterations.

Dr. Pournaderi PS, the lead scientists said, "6-gingerol showed beneficial effects in the EV induced PCOS rats via decreased expression of COX-2, restored biochemical parameters to normal and decreased of cysts in the ovaries".

In other words, 6 gingerols improved the fertile profile of female Wistar rats through restored the normal function of the ovaries.

Taken altogether, ginger processed a major compound 6 gingerols may be considered a functional remedy for the treatment of female infertility caused by overexpression of ovarian cysts patients with PCOS, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) The effects of 6-Gingerol on reproductive improvement, liver functioning and Cyclooxygenase-2 gene expression in estradiol valerate - Induced polycystic ovary syndrome in Wistar rats by Pournaderi PS1, Yaghmaei P2, Khodaei H3, Noormohammadi Z1, Hejazi SH. (PubMed)

(2) Effect of different combinations of MGK-264 or piperonyl butoxide with plant-derived molluscicides on snail reproduction by Singh K1, Singh DK. (PubMed)
(3) Obesity and reproductive dysfunction in women. by Moran LJ1, Dodd J, Nisenblat V, Norman RJ (PubMed).

Phytochemical Sinigrin, Prevents Plaques Build-Up on the Arterial Wall Against the Onset of Atherosclerosis in Vivo

By Kyle J. Norton

Sinigrin may be used as a natural and bioactive compound for the treatment of atherosclerosis, according to studies.

Atherosclerosis is a chronic and medical condition characterized by the plaque accumulated on the arterial wall, leading to stiffing and hardening arteries.

Arteries are the blood vessels that carry the oxygen-rich blood to the heart and other parts of the body.

Atherosclerosis is one of the leading cause of heart disease and stroke, depending on the area of blocking in the arteries.

Plaque is a combination of cholesterol, calcium, cadmium and other harmful chemical substances found in the blood.

The exact causes of atherosclerosis are not identified. Researchers as of today do not know why people with the same health condition, some are prone to the disease onset while others do not.

However, damage or injury of the inner layer of an artery, high blood pressure and cholesterol and medical conditions such as arthritis, lupus or infections, or inflammation of unknown cause have been found to increase the risk of atherosclerosis.

Due to plaque accumulation associated with high blood cholesterol, some researchers suggested that
 an unhealthy diet high in saturated fat and trans fat may be the major cause as well as increasing the severity of the condition.

Dt. Zhao Y said, "The WZSPs (n = 9) were fed a high-cholesterol and high-fat diet (HCFD). After continuous feeding, 3 WZSPs each were sacrificed at 6, 8, and 12 months, respectively, and the general clinical manifestations and serological indexes were detected".
And, " At 12 months, atherosclerotic lesions could be found in all major arteries, while lipid core, cholesterol precipitation, and calcium deposition appeared in the most serious sites".

The results clearly indicated the risk of atherosclerosis is substantially increased in animals fed with long-term high fat diet.

On finding a natural compound for the treatment of atherosclerosis with no side effects, researchers investigated sinigrin anti-plaque accumulation in an animal model.

In ApoE mice, the injection of sinigrin suppressed the expression of the genes directly involved in the formation of atherosclerotic lesions.

Sinigrin lowered the blood levels of cholesterol LDH, triglyceride, and cholesterol in serum without affecting the levels HDL. In other words, sinigrin promoted the return of blood cholesterol back to the liver, therefore, repressing the risk of cholesterol accompanied by other substances to form plaques on the arterial wall in facilitating the onset of atherosclerosis.

Futhermore, injection of sinigrin also promoted lipid homeostasis, through reducing levels of the proteins associated with lipid metabolism.

Moreover, the bioactive compound also reduced the production of proinflammatory cytokines induced by the overexpression of free radicals, and the accumulation of modified LDL within the intima of the artery.through its antioxidant activity.

More precisely, the bioactive compound reduced the expression of proinflammatory cytokines by suppressing the activation of the signaling protein associated with a wide range of processes such as immunity, inflammation.

In ApoE-/- mice induced atherosclerosis, application of sinigrin exerted the similar effect by reducing the levels of serum concentrations of lactate dehydrogenase (LDH), triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), calcium (Ca2+), and pro-inflammatory cytokines.

Oral administration of sinigrin attenuated the expression of proteins involved in the initiation of atherosclerosis. 

Taken altogether, sinigrin a bioactive ingredient in cruciferous vegetables may be considered a functional supplement for the prevention and treatment of atherosclerosis, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sinigrin attenuates the progression of atherosclerosis in ApoE-/- mice fed a high-cholesterol diet potentially by inhibiting VCAM-1 expression by Jang YJ1, Park B1, Lee HW1, Park HJ1, Koo HJ2, Kim BO3, Sohn EH4, Um SH5, Pyo S. (PubMed)
(2) Sinigrin and Its Therapeutic Benefits by Anisha Mazumder, Anupma Dwivedi and Jeanetta du Plessis. (Molecules)
(3) Atherosclerosis Induced by a High-Cholesterol and High-Fat Diet in the Inbred Strain of the Wuzhishan Miniature Pig by Zhao Y1, Xiang L1, Liu Y1, Niu M1, Yuan J1, Chen H. (PubMed)

Bromelain, the Potential and Natural Treatment of Arthritis with No Side Effects

By Kyle J. Norton

Arthritis is a class of disease associated with the inflammation of one or more of your joints, including rheumatoid arthritis.

Most common symptoms of arthritis are joint pain and stiffness.

According to the statistics provided by the Arthritis Foundation, in the US, approximately, 54 million adults have doctor-diagnosed arthritis accompanied by 300,000 babies and children.

The most common type of arthritis is osteoarthritis which affects over 30 million Americans. Believe it or not, by 2040, the number of people with arthritis will be increased to more than 78 million.

Epidemiologically, certain factors such as family history with some types of arthritis, age, gender, a previous joint injury that was not treated properly can contribute to the risk of the disease.

However, some researchers suggested the widespread obesity in the US may be one of the important features that increase the prevalence of arthritis.

Dr. Lauren K. King wrote, "Obesity is associated with the incidence and progression of OA of both weight-bearing and non-weight-bearing joints, to rate of joint replacements as well as operative complications".

And, "Weight loss in OA can impart clinically significant improvements in pain and delay progression of joint structural damage. Further work is required to determine the relative contributions of mechanical and metabolic factors in the pathogenesis of OA.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a natural compound for diseases associated with inflammation, researchers investigated the efficacy of long-term prophylactic enzyme therapy and combination therapy with cyclosporin in an animal model.

Selected rats with collagen-induced arthritis were divided into administration of the following drugs: cyclosporin A (5 mg/kg/day and 10 mg/kg/day orally); a mixture of enzymes containing pure substances (bromelain, trypsin, rutin) in the same ratio as in Phlogenzym (PHL, 150 mg/kg, twice daily intrarectally); and a combination of 5 mg/kg/day cyclosporin A plus 300 mg/kg/day PHL for a period of 50 days from the immunization.

According to the tested assays, a mixture of enzymes containing pure substances (bromelain, trypsin, rutin showed a similar effect in significant inhibition of both inflammation and destructive arthritis-associated changes compared to the treatment with 10 mg/kg cyclosporin A, and combination therapy with half dosages of cyclosporin A (5 mg/kg) plus PHL.

However, PHL alone reduced the disease markers  to a lesser extent compared to the enzyme therapy which exerts a similar effect but at a later stage of arthritis development.

Based on the findings, researchers at the Research Institute of Rheumatic Diseases said, "Our results show the inhibitory effect of enzyme therapy on collagen-induced arthritis in rats, as well as the efficacy of cyclosporin A given in low doses in combination with enzyme therapy, which may be useful in the treatment of rheumatoid arthritis".

In order to find more information about bromelain anti-arthritis activity, researchers at the same institute examined the results in rats with adjuvant-induced arthritis administered either cyclosporin A (2.5 or 5.0 mg/kg/day per os), a mixture of enzymes (Phlogenzym (PHL); 45 mg/kg twice daily intrarectally), or a combination of 2.5 mg cyclosporin A and 90 mg PHL for a period of 40 days from the adjuvant application.

Combination therapy with cyclosporin A plus PH significantly inhibited both the inflammation and destructive arthritis-associated changes similar to that of 5 mg of cyclosporin A.

PHL administrated alone also inhibited all arthritic markers in a lesser extent and at a later stage of arthritis development similar to the treatment of 2.5 mg of cyclosporin A.

Dr. Rovenská E, after taking into account of co and confounder wrote, "The results show the inhibitory effect of enzyme therapy on rat adjuvant arthritis, as well as the efficacy of a low dose of cyclosporin A given in combination with enzyme therapy, which may be useful in the treatment of rheumatoid arthritis".

Taken altogether, bromelain used alone or combined with other herbal medicines may be considered supplements for the treatment of arthritis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibitory effect of enzyme therapy and combination therapy with cyclosporin A on collagen-induced arthritis by Rovenská E1, Svík K, Stancíková M, Rovenský J. (PubMed)
(2) Enzyme and combination therapy with cyclosporin A in the rat developing adjuvant arthritis by Rovenská E1, Svík K, Stancíková M, Rovenský J. (PubMed)
(3) Obesity & osteoarthritis by Lauren K. King,* Lyn March,** and Ananthila Anandacoomarasamy. (PMC)

Herbal Bilberry, the Natural Treatment of Ulcerative Colitis

By Kyle J. Norton


Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) caused by the inflammation associated with colon and rectum.

Symptoms of UC is totally depending on the severity of the disease, including diarrhea, often with blood or pus,  persistently abdominal pain,  rectal pain, and bleeding, particularly the inability to defecate despite urgency. 

Some patients with UC may also have symptoms of weight loss, fatigue fever.

According to the statistics in the US, out of 1.6 million Americans with inflammatory bowel disease, 907,000 of them have ulcerative colitis.

Depending on the location, most common types of  UC can be classified into 

* Acute severe ulcerative colitis is a medical emergency that requires immediate hospitalization. The condition affects the entire colon with severe acute symptoms of pain, profuse diarrhea, bleeding, fever.

* Ulcerative proctitis is an Inflammation of the anus (rectum), inducing symptoms of rectal bleeding.

* Proctosigmoiditis is an Inflammation involved the rectum and sigmoid colon (lower end of the colon). 

The exact causes of UC are not cleared. Some researchers suggested there are a complex interaction of genetics, immune response, and environmental triggers that cause the onset of the disease.

Most common risk factors of UC include genetic preposition, autoimmune diseases, smoking, use of certain medications such as antibiotics, and smoking.

Some researchers suggested that UC may be correlated with the increase of the age as the disease affected 10–30% of the population older than 60 years.

Dr. Wei-Chen, the lead scientist wrote, " Elderly patients with UC will be seen more frequently with the aging of the population and increasing incidence of UC. The management of UC in the elderly population is more complex due to comorbidities and polypharmacy".

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

On finding a natural compound or whole food for the treatment of ulcerative colitis (UC), as a significant fraction of patients with ulcerative colitis (UC) is not sufficiently controlled with conventional therapy or suffers from therapy-related side effects, researchers examined the anthocyanin-rich bilberry extract (ARBE) on the colon specimens obtained during an open pilot study using ARBE for the treatment of mild-to-moderate UC.

Pretreatment of ARBE inhibited the expression of IFN-γ-receptor 2 which plays a critical role in the regulation of mediated immune responses and organ-specific autoimmunity in human THP-1 monocytic cells.

After 6 weeks of treatment, ARBE treatment revealed reduced the production of the pro-inflammatory cytokines including IFN-γ and TNF-α.

Furthermore, ARBE treatment featured enhanced levels of Th17-cell-specific cytokine IL-22 and immunoregulatory cytokine IL-10 by restoring the balance between Th17 and Treg cells and preventing the risk of chronic inflammation and pathogenesis of many autoimmune diseases.

Dr. Roth S, the lead scientist after taking other factors into account wrote, "a molecular mechanism underlying the anti-inflammatory effects of ARBE treatment in UC patients by modulating T-cell cytokine signaling and inhibiting IFN-γ signal transduction".

In order to reveal more information about the bilberries (Vaccinium myrtillus) property on UC, researchers analyzed the antioxidative and anti-inflammatory effects with an aim to explore the therapeutic potential of bilberries in active UC.

The open pilot trial with a total follow-up of 9 weeks the effect of a daily standardized anthocyanin-rich bilberry preparation included 13 patients with mild to moderate UC. 

At the end of the 6-week treatment interval, 63.4% of patients achieved remission, the primary endpoint, while 90.9% of patients showed a response.

In all patients, a decrease in total Mayo score was detected (mean: 6.5 and 3.6 at screening and week 7, respectively; p<0.001).

Fecal calprotectin levels significantly decreased during the treatment phase (baseline: mean 778 μg/g, range 192-1790 μg/g; end of treatment: mean 305 μg/g, range <30-1586 μg/g; p=0.049), including 4 patients achieving undetectable levels at end of treatment.

No serious adverse events were observed.

The finding strongly supports the regular use of standardized anthocyanin-rich bilberry preparation in UC in humans.

Dr. Biedermann L, said at the end of the experience, "These results clearly indicate a therapeutic potential of bilberries in UC. Further studies on mechanisms and randomized clinical trials are warranted".

Taken altogether, bilberry processed abundantly bioactive compound anthocyanin may be considered a functional remedy for the prevention and treatment of UC, pending to the validation of larger sample size and multicenter human study.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Bilberry-Derived Anthocyanins Modulate Cytokine Expression in the Intestine of Patients with Ulcerative Colitis by Roth S1, Spalinger MR1, Gottier C1, Biedermann L1, Zeitz J1, Lang S1, Weber A2, Rogler G1,3, Scharl M. (PubMed)
(2) Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis - an open pilot study by Biedermann L1, Mwinyi J, Scharl M, Frei P, Zeitz J, Kullak-Ublick GA, Vavricka SR, Fried M, Weber A, Humpf HU, Peschke S, Jetter A, Krammer G, Rogler G. (PubMed)
(3) Ulcerative Colitis in Elderly People: An Emerging Issue by Wei-ChenLin, Ming-JenChen, Cheng-HsinChua, Tsang-EnWang, Horng-YuanWang, Chen-WangChang. (Science Direct)