Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Wednesday, 27 February 2019

Herbal Aloe Vera, the Promising Topical Wound Healing Functional Remedy, Researchers Say

By Kyle J. Norton

Herbal aloe vera may be used for speeding up the skin wound healing with no side effects, some researchers suggested.

Wound healing is the natural process of repair of skin damage and injury.

The process of skin healing in human is gone through several stages. First, the immune system after sensing the skin wound activates the immune first line defense stimulating the constriction of the blood vessel to reduce blood flow, activate platelets, and many different clotting factors to cover the wound area.

Then, the white blood cells also up-regulate the proteins associated with the production of proinflammatory cytokines to the site of infection to kill off all the invasive organisms.

In most cases, due to overproduction of proinflammatory cytokines, patients may experience symptoms of fever, and localized pain, redness, and swelling.

Furthermore, the production of pro-inflammatory cytokines in some case can cause the death of nearby healthy cells, leading to the formation of irreversible scars, as seen in the liver.

After the inflammatory phase, the new blood vessels are formed and the new granulation tissues are built.

The final phase of the wound healing is involved in the remodeling of collagen from type III to type I cellular activity reduces.

If the process of skin healing is interrupted, it may lead to abnormal cell membrane repair, a major cause of skin scars.

MG53 is a protein involved in tissue repair and regeneration and also considered a facilitator of rapid injury repair, a mediator of cell migration, and a modulator of myofibroblast differentiation during wound healing. The defection and down-regulation of MG53 protein may delay wound healing and abnormal scarring.

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan.

It has become very popular for commercial cultivation due to its health benefits. Aloe vera has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated cholesterol, etc. It is also one of many popular herbs studied in scientific ways with some conflicting results.

The ten main areas of chemical constituents of Aloe vera include amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.

They all work together in a synergistic way to create healing and health-giving benefits, according to Gertrude Baldwin in the article of THE BENEFITS OF THE USE OF ALOE VERA IN HERBAL PREPARATIONS.

On finding the natural compound or remedy for speeding up the treatment of wound healing, researchers examined the efficacy of aloe vera through searching the data of online medical literature.

Only controlled clinical trials for burn healing were included. There were no restrictions on any language of publication. Only 4 Four with a total of 371 patients were included in this review.

According to the meta-analysis using the duration of wound healing as an outcome measure, the healing time of the aloe vera group was 8.79 days shorter than those in the control group.

The cumulative evidence support that aloe vera can be an effective intervention used in burn wound healing for first to second-degree burns.

Furthermore, in order to maximize the effect of Aloe vera in wound healing, researchers examined the formulate and optimize a herbal gel of Aloe vera extract containing Carbopol 934 as a gelling agent.

During the observation of differences in wound healing between the various treatments when compared to the control group. researchers found that tissue hyperplasia was lower in the control group compared to the other treated groups.

In animals group treated with gel, exerted an 80.14% healing up to 14(th) day compared to the untreated group I (control) animals of showed 52.68%.

Control group animals also showed inflammation and pus formation up to 5(th) day of study, compared to none in the treatment group.

These results supported the use of topical application of Carbopol 934 gel containing Aloe vera extract on the healing of skin wounds.

Taken altogether, herbal Aloe vera may be considered a functional topical remedy for the treatment of skin wound, pending to the confirmation of large sample size and multicenter human study.

References
(1) The efficacy of aloe vera used for burn wound healing: a systematic review by Maenthaisong R, Chaiyakunapruk N, Niruntraporn S, Kongkaew C.(PubMed)
(2) Aloe vera for treating acute and chronic wounds. by Dat AD, Poon F, Pham KB, Doust J.(PubMed)
(3) Effects of Aloe vera cream on posthemorrhoidectomy pain and wound healing: results of a randomized, blind, placebo-control study, by Eshghi F, Hosseinimehr SJ, Rahmani N, Khademloo M, Norozi MS, Hojati O.(PubMed)
(4) Formulation development, optimization and evaluation of aloe vera gel for wound healing by Khan AW, Kotta S, Ansari SH, Sharma RK, Kumar A, Ali J.(PubMed)
(5)

Modulation of Wound Healing and Scar Formation by MG53 Protein-mediated Cell Membrane Repair by Haichang Li,‡,1,2 Pu Duann,‡,1 Pei-Hui Lin,‡ Li Zhao,‡§ Zhaobo Fan,¶ Tao Tan,‡§ Xinyu Zhou,‡Mingzhai Sun,‡ Minghuan Fu,¶ Matthew Orange,‖ Matthew Sermersheim,‡ Hanley Ma,‡**Duofen He,‡‡ Steven M. Steinberg,‡ Robert Higgins,‡ Hua Zhu,‡ Elizabeth John,§Chunyu Zeng,‡‡ Jianjun Guan,¶ and Jianjie Ma. (PMC)

Tuesday, 26 February 2019

Turmeric, the Natural Remedy for the Treatment of Metabolic Syndrome (MS)

By Kyle J. Norton

Scientists may have found a natural herbal remedy for the treatment of metabolic syndrome with no side effects, according to studies.

Metabolic syndrome is a cluster of conditions associated with an increased risk of cardiovascular disease and diabetes including too much fat around the waist, high blood sugar and cholesterol and pressure, high triglycerides and low high-density lipoprotein (HDL) cholesterol.

If you have any 3 of the aforementioned conditions, you are at a higher risk of having CVD and diabetes.

The exact causes of metabolic syndrome are unidentified. However, researchers suggested eating too many calories, particularly in high-fat diet, physical inactivity, and excessive weight gain are some of the most common and prevalent factors in elevated the risk of metabolic syndrome in the Western world.

Most people with metabolic syndrome do not experience any symptoms until the condition progression into a later stage, overtimes, leading to insulin resistance and plagues built-up on the wall of the arteries.

Other risk factors increased the risk of metabolic syndrome include aging, race, family history, long-term hormone imbalance such as polycystic ovary syndrome (PCOS), gestational diabetes.

Some researchers in the concern about the widespread metabolic syndrome in obese patients suggested that the promotion of the Western diet over the past many decades may be one of the culprits in inducing the onset of metabolic syndrome.

Dr. the lead scientist in the cardiovascular disease team said, "The cellular mechanisms of metabolic syndrome include mitochondrial overload, de novo lipogenesis, hepatic insulin resistance, and hyperinsulinemia, reactive oxygen species formation, endoplasmic reticulum stress, and the unfolded protein response"

And, "Specific alterations of the Western Diet uniquely drive this process and are unrelated to calories. These alterations include too little fiber, omega-3 fatty acids, and micronutrients, and too many omega-6 fatty acids, trans-fats, branched-chain amino acids, ethanol, and fructose. The food industry invokes personal responsibility while denying any corporate responsibility and citing scientific, policy, and social arguments. However, their responses obfuscate the scientific truth in order to obviate their culpability".

The findings suggested that obesity is a marker of the metabolic syndrome rather than a cause, However, if you are obese, your risk of metabolic syndrome increases substantially.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In the urgency to find a natural remedy for the treatment of metabolic syndrome, researchers compared the clinical efficacy of black seeds and turmeric alone and its co-administration in lower doses among patients with metabolic syndrome (MS).

The double-blind-randomized-controlled trial included healthy males (n=250), who screened positive for MS, were randomized to either black seeds (1.5g/day), turmeric (2.4g/day), its combination (900mg black seeds and 1.5g turmeric/day) or placebo for 8 weeks.

At 4 weeks, compared to baseline, turmeric alone significantly improved a number of certain conditions of metabolic syndrome such as body-mass-index (BMI), body-fat-percent (BF%), waist circumference (WC).

Combined with black seeds, turmeric improved all parameters except HDL-cholesterol with lower fasting blood glucose (FBG) and LDL-cholesterol, compared to placebo.

At the 8 weeks, turmeric reduced LDL-cholesterol and c-reactive protein (CRP), a marker of inflammation, and the combination group with 60% dose of the individual herbs showed an improvement in all parameters compared to baseline.

Based on the findings, researchers said, "The combination of Black seeds and Turmeric can, therefore, be recommended with lifestyle modification as a starting point for patients with MetS to halt its future complications and progression".

In order to confirm the efficacy of black seeds used combined with turmeric for the treatment of metabolic syndrome, researchers once against conducted a joint study using a fructose-fed rat model of MS.

in vivo, different doses of black seeds and turmeric, individually and in combination, were administered to fructose-fed rats for up to 6 weeks with characteristic features of MS.

At 3 weeks of the treatment, turmeric lowered low-density lipoprotein cholesterol, compared to coadministration which reduced both high blood pressure and hypertriglyceridemia.

At 6 weeks, the coadministration of both herbs, at half the doses of individual herbs, was the most effective in preventing hypertension, hyperglycemia, dyslipidemia, hyperinsulinemia, and endothelial dysfunction compared to those of individual herbs.

The results strongly suggested that turmeric used alone or combined with black seeds may be considered a functional food or formula for the prevention and treatment of metabolic syndrome by inhibiting the conditions in the cluster of the MS, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Clinical efficacy of the co-administration of Turmeric and Black seeds (Kalongi) in metabolic syndrome - a double blind randomized controlled trial - TAK-MetS trial by Amin F1, Islam N2, Anila N3, Gilani AH. (PubMed)
(2) Coadministration of black seeds and turmeric shows enhanced efficacy in preventing metabolic syndrome in fructose-fed rats by Amin F1, Gilani AH, Mehmood MH, Siddiqui BS, Khatoon N. (PubMed)
(3) Metabolic Syndrome and Obesity in Childhood and AdolescenceEditor(s): Kiess, W. (Leipzig), Wabitsch, M. (Ulm), Maffeis, C. (Verona) and Sharma, A.M. (Edmonton, Alta.). (Karger)

Ginger, the Best Natural Remedy with Anti Colon Cancer Potential

By Kyle J. Norton

Scientists may have found a kitchen spice which processes a potential to treat colon cancer, according to studies.

Colon cancer is a medicinal condition associated with irregular cell growth in the colon tissues.

According to the statistics provided by the Stat-Canada, 1 in 16 Canadian men and 1 in 18 women will develop colorectal cancer over their lifetime. The cancer is the third leading cause of death behind prostate and lung cancer.

Every year, approximately 26,,000 Canadians are diagnosed with colorectal cancer, represented 13% of all new cancer cases.

Colon cancer is a slow growth cancer, therefore, most colon cancer is detected in the later stage after the experiencing symptoms of blood in your stool or an ongoing change in bowel habits. In other words, only 39% of colorectal cancer is detected in the early stage.

The 5-year survival rate of localized stage colorectal cancer is 90%.

The cause of colon cancer is a result of the alternation of cell DNA. Researchers do not why? people with the same health conditions and family history, some are susceptible to the onset of the disease, while others do not.

Although there are many factors associated with the onset of colon cancer, aging may be one of the most prevalent risks. It probably is due to the disease taken over 10 to 15 years before the patients experience some related symptoms. In other words, according to epidemiological studies, the majority of colorectal cancers occur in people older than 50.

"70% of colorectal cancer is diagnosed in patients over 65. Evaluation of the influence of age and comorbidity on survival and cause of death in a non-selected population".

And, "In colon cancer patient age and comorbidity predict survival. This represents possible bias or a reduced survival benefit of treatment, and is an indication that colon cancer is not the prognosis defining illness in the majority of patients".

The result strongly suggested that colon cancer affects mostly the aging population over 65 years of age. The simultaneous presence of two chronic diseases or conditions in elderly patients is associated with the poor survival rate.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on the finding a bioactive compound to replace the chemo medication which induces serious side effects to cancer patients examined 6-Gingerol, a natural component of ginger, anti-colon cancer activity.

Injection of 6-gingerol treatment significantly reduced the cell viability of human colon cancer cell, LoVo, in a dose-dependent manner.

Furthermore, 6-gingerol induced significant G2/M phase arrest and had a slight influence on the sub-G1 phase in LoVo cells, according to the flow cytometric analysis and observed by the reduced levels of a protein involved cancer cell cycle.

Moreover, 6-gingerol also induced cancer cell apoptosis by elevating the functions of levels of tumor suppressive genes and exhibiting cytotoxicity through elevated intracellular reactive oxygen species (ROS).

These results strongly suggested 6-gingerol should be beneficial to the treatment of colon cancer, according to Dr. Lin CB and colleagues.

In order to understand more the effect of ginger on colon cancer, researchers investigated a novel prodrug of aspirin, [6]-gingerol aspirinate (GAS) against colon cancer.

GAS exerted enhanced anti-cancer properties in vitro and superior gastroprotective effects in mice. by suppressing the enzymes involved mediation of tumor repopulation.

Importantly, GAS was also able to survive stomach acid and decomposed in intestinal linings or after absorption to simultaneously release ASA and [6]-gingerol.

Dr. Yingdong Zhu, the lead scientist said in the final report, "Our results demonstrate the enhanced anticancer properties along with gastroprotective effects of GAS, suggesting that GAS can be a therapeutic equivalent for ASA in inflammatory and proliferative diseases without the deleterious effects on stomach mucosa".

Taken altogether, ginger processed a highly active bio-compound may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of colon cancer with no side effects, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) 6-Gingerol Inhibits Growth of Colon Cancer Cell LoVo via Induction of G2/M Arrest by Lin CB1, Lin CC, Tsay GJ.(PubMed)
(2) Gastroprotective [6]-Gingerol Aspirinate as a Novel Chemopreventive Prodrug of Aspirin for Colon Cancer by Yingdong Zhu, Fang Wang, Yantao Zhao, Pei Wang & Shengmin Sang. (Scientific Report)
(3) Impact of age and comorbidity on survival in colorectal cancer by Elmer E. van Eeghen, Sandra D. Bakker, Aart van Bochove, and Ruud J. L. F. Loffeld. (PMC)

Ginger, the Anti Chronic Mild Stress and Arteriosclerosis Natural Remedy

By Kyle J. Norton

Scientists may have found a natural remedy which processes a potential to treat chronic mild stress, according to studies.

Acute stress is a natural and emotional reaction that arises in response to a terrifying or traumatic event or witnessing a traumatic event. People react to acute stress differently depending on life experiences.

Chronic stress, a medical condition is a result of a person who can not respond to emotional pressure properly, leading to traumatic stress which he or she can not control.

Untreated ongoing chronic stress has been found to exacerbate many serious health conditions, including depression, anxiety, and personality disorders.

Epidemiological studies suggested that certain physical health problems are also associated with patients with long-term stress, including heart disease, high blood pressure, abnormal heart rhythms, heart attacks, and stroke.

There are many risk factors involving the onset of chronic stress. However, job-related chronic stress has been found in most American adults in the Western world.

The American Institute of Stress in examing the chronic stress in the American adults wrote, "Numerous studies show that job stress is far and away the major source of stress for American adults and that it has escalated progressively over the past few decades. Increased levels of job stress as assessed by the perception of having little control but lots of demands have been demonstrated to be associated with increased rates of heart attack, hypertension, and other disorders".

According to the American Workplace VII statistics, 80% of workers feel stress on the job, nearly half say they need help in learning how to manage stress and 42% say their coworkers need such help.

Mice were exposed to CMS for 20 weeks, at week 5, they were fed with a high-fat diet (HFD), then received 6-Gin (20 mg/kg/day, intragastrically) treatment.

CMS before application of high-fat diet exerted a significant effect in reducing body weight gain, sucrose preference, and locomotor activity, the expression of some of the core symptoms of depression.

Furthermore, CMS mice fed with a high-fat diet (HFD) after week 5 also showed the increased plaque formation, elevation of plasma total cholesterol, triglyceride, low-density lipoprotein cholesterin, and proinflammatory cytokines including TNF-α, IL-1β, and IL-6, all indicated the development of atherosclerotic lesions.

However, injection of 6-Gin not only reduced the expression induced by high-fat diet but modulated the function of enzymes activated glucose and fatty acid uptake and oxidation, catalyzed the committed step in fatty acid synthesis, produced cholesterol and other isoprenoids, particularly the lipid synthesis in the liver tissues.

These results suggested the role of ginger in the alleviated atherosclerotic lesions and reversed the expression levels of lipid profiles and inflammatory cytokines in stressed mice.

Dr. Wang S, the lead scientist wrote, "the antiatherosclerotic effects of 6-Gin is mediated in part by the AMPK signaling pathway, which is closely associated with cholesterol synthesis and lipid accumulation".

Where AMP-activated protein kinase (AMPK) plays a key role as a master regulator of cellular energy homeostasis, in response to low glucose, hypoxia, ischemia, and heat shock.

Additionally, CMS also showed an improvement of several aspects of chronic stress on the injection of 6-Gin.

The finding clearly suggested 6-Gin attenuates arteriosclerosis in ApoE-/- mice exposed to CMS and HFD, and it may be a potential therapeutic agent for the treatment of atherosclerosis similar to that of conventional medicine.

Taken altogether, ginger processed abundantly bioactive compound 6-gingerol may be considered a functional remedy for the prevention and combined with the primary medicine for the treatment of chronic mild stress and atherosclerosis, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) 6-Gingerol Ameliorates Behavioral Changes and Atherosclerotic Lesions in ApoE-/- Mice Exposed to Chronic Mild Stress by Wang S1, Tian M2, Yang R1, Jing Y1, Chen W1, Wang J1, Zheng X1, Wang F. (PubMed)
(2) Transforming stress through awareness, education, and collaboration by AIS

Ginger, the Natural Antibiofilm Remedy with No Side Effects

By Kyle J. Norton

Scientists may have a kitchen remedy which processes a potential to improve the immune function against infection, some studies suggested.

A biofilm is a system that can be adapted internally to environmental conditions by its inhabitants. In other words, biofilm-forming from bacteria is one of the common forms of bacterial infection affecting up to 80% of human bacterial infections.

In biology, biofilm used by the bacteria as a natural defense mechanism of bacteria to survive under harsh environments, by attaching to a solid surface in a large community, including the skin, teeth, and mucosa.

Bacterial initiates biofilm formation with an aim to greatly enhance survival in hosts and cause chronic infections, leading to long-term inflammation and tissue damages.

The formation of a biofilm of bacteria may go through 2 stages, the adhesion phase is the stage that the bacteria attach to the surface or accumulates on a surface, After the adhesion phase, the bacteria enter the colonial phase, where the bacteria continue to grow, leading to the formation of dense bacterial aggregates.

Dr. Li XH, the lead scientist in examing the new anti-biofilm agents, said, "In biofilms, microorganisms become much more resistant to antimicrobial treatments, harsh environmental conditions, and host immunity".

And, "Currently, it is believed over 80% of chronic infectious diseases are mediated by biofilms, and it is known that conventional antibiotic medications are inadequate at eradicating this biofilm-mediated infection".

The anti-biofilm activiti of ginger caused a reduction of 39–56% when the ginger extract was added to the culture.

The ginger extract also decreased the production of extracellular polymeric substances, the fundamental component that determines the physiochemical properties of a biofilm, according to the chemical analysis and confocal laser scanning microscopy.

Furthermore, ginger extract formed noticeably less rugose colonies on agar plates containing Congo red and facilitated swarming motility on soft agar plates.

The ginger extract also inhibited biofilm formation in both Gram-positive and Gram-negative bacteria.

The efficacy of ginger extract was attributed to the reduced level of a second messenger, bis-(3′-5′)-cyclic dimeric guanosine monophosphate in the induction of biofilm formation.

Also, surface biofilm cells formed with ginger extract detached more easily with surfactant than did those without ginger extract.

The results strongly support the use of ginger as a broad spectrum biofilm inhibitor, in the reduction of bacterial biofilm formation, a major cause of serious health problems.

In order to reveal more information about the ginger effect against biofilm formation, researchers examined the bioactive compounds on Candida albicans.

6-gingerol, 8-gingerol, and 6-shogaol effectively inhibited biofilm formation and 6-shogaol at 10 μg/ml significantly reduced C. albicans biofilm formation with no harming the planktonic cell growth.

Moreover, 6-gingerol and 6-shogaol inhibited hyphal growth in embedded colonies and free-living planktonic cells, and prevented cell aggregation.

Additionally, 6-gingerol and 6-shogaol reduced C. albicans virulence in a nematode infection model without causing toxicity at the tested concentrations.

Dr. Jin-Hyung Lee,, the lead scientist wrote in the final report, "These results highlight the antibiofilm and antivirulence activities of the ginger components, 6-gingerol and 6-shogaol, against a drug-resistant C. albicans strain".

Taken altogether, ginger processed a high amount of bioactive compound may be considered a functional remedy for the prevention of bacterial infection by inhibiting the biofilm activity of micro pathogens.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Ginger Extract Inhibits Biofilm Formation by Pseudomonas aeruginosa PA14 by Han-Shin Kim and Hee-Deung Park. (PMC)
(2) Antibiofilm and Antivirulence Activities of 6-Gingerol and 6-Shogaol Against Candida albicans Due to Hyphal Inhibition by Jin-Hyung Lee,1,† Yong-Guy Kim,1,† Pilju Choi,2 Jungyeob Ham,2 Jae Gyu Park,3,* andJintae Lee. (PMC)
(3) Antibiofilm agents: A new perspective for antimicrobial strategy by Li XH1, Lee JH2. (PubMed)

Sunday, 24 February 2019

Ginger Reverses the Cognitive Impairment Caused by Oxidative Stress

By Kyle J. Norton

Scientists may have found a pungent spice which processes a potential to inhibit the early onset of cognitive impairment, a major cause of neurodegenerative diseases in the elderly, according to studies.

Cognitive impairment is a medical condition characterized by a noticeable loss of cognitive abilities, involved memory and thinking skill. Cognitive impairment in the elderly is an early sign that can lead to the progression of dementia, including Alzheimer's.

The neuro impairment can be caused by brain damage due to physical impact, a medical condition such as mild stroke. In the elderly, the syndrome was associated with the build-up of plagues or tangles in the neurons that affect the cells in transmitting information to the others.

Some researchers suggested that enlargement of the brain's fluid-filled spaces and shrinkage of the hippocampus may also cause the onset of cognitive impairment.

Dr. Terry L. Davidson PhD and colleagues in examing the risk of cognitive impairment of people who follow the Western diet suggested that the Western diet may play a critic role in facilitating the widespread of cognitive impairment in the elderly in the Western world compared to the people who follow the traditional diet with a high amount of fruits and vegetables.

The doctoral team wrote, "Epidemiological studies indicate that Western diet intake, and the weight gain and obesity that it promotes, are associated not only with late-life dementia but also with poorer cognitive flexibility and inhibitory control across the lifespan".

And, " In addition, rodents maintained on a Western diet are impaired on hippocampal-dependent inhibitory learning and memory tasks and exhibit increased blood-brain barrier permeability, hippocampal inflammation, and decreased hippocampal neurogenesis and plasticity. Interference with neuroendocrine signaling may also contribute to hippocampal dysfunction".

The results strongly suggested the negative impacts of the Western diet in the initiation of a vicious cycle of progressive weight gain and cognitive decline.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding a natural compound for the treatment of cognitive impairment examined the ginger effect on oxidative stress in the induction of cognitive impairment.

The study included 60 participants randomly assigned to receive a placebo or standardized plant extract at doses of 400 and 800 mg once daily for 2 months.

Ginger-treated groups had significantly decreased P300 latencies, increased N100 and P300 amplitudes, and exhibited enhanced working memory.

After one month of treatment, Zingiber officinale treated group at a dose of 800 mg showed a significant increase in N100 amplitude. After two months, Zingiber officinale treated group at doses of 400 and 800 mg showed a significant increase in P300 amplitude.
Furthermore, Zinigber officinale treated group at a dose of 800 mg showed a significant increase in N100 amplitude and decreased P300 latency.

Therefore, ginger is a potential cognitive enhancer for middle-aged women.

The P300 wave is a measurable direct reaction of the brain to a certain sensory, cognitive or mechanical stimulus against cognitive dysfunction. P300 latency is found to increase in patients with Alzheimer's disease.

The increase of N100 and N300 auditory sensory gating could reflect mechanisms involved in protecting higher-order cognitive functions. P300 measurements are used to measure the increasing sensitivity to early cognitive decline or disease progression in AD patients.

In order to reveal more information about the ginger activity against cognitive impairment, researchers examined the ginger effects on healthy brains in mice.

GE administration significantly improved the ability of mice to recognize novel objects, indicating improvements in learning and memory.

GE administration led to elevated NGF levels in both the mouse hippocampus and rat glioma C6 cells.

Where nerve growth factor (NGF) is involved primarily in the growth, and maintenance, proliferation, and survival of neurons, thus improving the cognitive function.

Moreover, GE administration also resulted in phosphorylation of extracellular-signal-regulated kinase (ERK) and cyclic AMP response element-binding protein (CREB), linking to the regulation of synaptic plasticity and memory formation revealed by Western blotting analysis.

Additionally, GE treatment significantly increased pre- and post-synaptic markers that pass nerve impulse from an axon terminal to a neuron, muscle cell, or gland cell, and synaptophysin, and PSD-95, which are related to synapse formation in the brain.

Dr. Lim S, the lead scientist in the final report wrote, "GE has a synaptogenic effect via NGF-induced ERK/CREB activation, resulting in memory enhancement".

Where The MAPK/ERK pathway is a chain of proteins in the cell that transmits information from a receptor on the surface of the cell to the DNA in the nucleus of the cell.

Taken altogether, ginger processed a high amount antioxidant bioactive compounds may be considered a functional remedy for the prevention and combined with the primary therapy for the treatment of cognitive impairment, pending to the confirmation of large sample and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Zingiber officinale Improves Cognitive Function of the Middle-Aged Healthy Women by Naritsara Saenghong, 1 Jintanaporn Wattanathorn, 2 ,* Supaporn Muchimapura, 2Terdthai Tongun, 2 Nawanant Piyavhatkul, 3 Chuleratana Banchonglikitkul, 4 andTanwarat Kajsongkram. (PubMed)
(2) Ginger improves cognitive function via NGF-induced ERK/CREB activation in the hippocampus of the mouse by Lim S1, Moon M2, Oh H1, Kim HG1, Kim SY3, Oh MS. (PubMed)
(3) Chapter 27 - Western Diet and Cognitive Impairment by Terry L.Davidson Ph.D., Camille H.Sample Ph.D., Scott E.Kanoski Ph.D. (Science Direct)

Ginger, the Best for the Prevention and Treatment of Metabolic Dysfunction with No Side Effects

By Kyle J. Norton

Scientists may have found a pungent spice which processes a potential to reverse metabolic dysfunction,
according to studies.

Metabolic dysfunction is a medical condition characterized by the improper function of the liver or pancreas.

In some cases, metabolic dysfunction may also be caused by enzyme deficiency due to a defective gene, including Antitrypsin (AAT) deficiency, a common metabolic liver disease that affects infants, children, and adults.

Liver, the large organ in human plays a critical role in breaking down old or damaged blood cells. and a central role in all metabolic processes, including fat metabolism by breaking down fat to energy for the body needs.

On the other hand, pancreas also converts the food we eat into energy for the body's cells by regulating blood glucose through the production of insulin.

Dysfunction of one of the 2 organs not only has strong impacts on the energy levels in the body but also increase the risk of diabetes and nonalcoholic liver disease.

According to the statistics provided by the Center for Diseases Control and Prevention, in the US, among adults aged 18 years or older, the prevalence of metabolic syndrome rose by more than 35% from 1988–1994 to 2007–2012, increasing from 25.3% to 34.2%. The rise of metabolic dysfunction is probably associated with the widespread obesity in the general population, some researchers suggested.

The risk factors associated with the onset of metabolic dysfunction include workers exposed to natural asbestos and to mixed asbestos stock dust, improper nutrition, excessive intake of food with high content of free sugar, saturated fatty acids and common salt with lack of chicken meat, cereals, fish, vegetables, fruits and cultured milk foods in diet and excessive body weight.

Most people with metabolic dysfunction do not experience any symptoms. However, if you have a large waist circumference and experience symptoms of high blood glucose, increased thirst and urination, fatigue, and blurred vision, you may have a metabolic disorder. Please check with your doctor to rule out of the possibility.

Ginger extract at doses of 200, 600, and 1800 mg/kg supplemented in the daily food of obese Balb/c mice for an 8-week showed a metabolic protective effect by preventing the increase of adiposity induced by HC diet, improving lipid profile, and promoting the decrease of inflammatory markers.

Furthermore, treated mice also exerted the decrease in the recruitment of cells visualized in vivo in the microvasculature of adipose tissue, a decrease of inflammatory cytokines, and an increase of adiponectin serum levels.

The finding suggested that ginger process anti metabolic dysfunction in obese mice induced by long-term high-refined carbohydrate (HC) diet.

In order to reveal more information about ginger anti-metabolic syndrome activity, used in traditional medicine, researchers examined the herbal effects on hyperlipidemia, hyperglycemia, oxidative stress, and inflammation.

Ginger showed a potency activity in reducing the onset of metabolic syndrome through
mediating the several transcription factors associated with the metabolic function, including activated glucose and fatty acid uptake.

The results indicated the beneficial effects of ginger on obesity and related complications in MetS.

Taken altogether, ginger may be considered a functional remedy for the prevention and treatment of metabolic dysfunction, pending to the confirmation of larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Ginger (Zingiber officinale Rosc.) Ameliorated Metabolic and Inflammatory Dysfunction Induced by High-Refined Carbohydrate-Containing Diet in Mice by Oliveira CT1, Lacerda DR1, Zicker MC1, Martins LB1, Teixeira MM2, Bello de Araujo RL1, Ferreira AVM. (PubMed)
(2) Beneficial effects of ginger Zingiber officinale Roscoe on obesity and metabolic syndrome: a review by Wang J1,2, Ke W1, Bao R1, Hu X1,2, Chen F. (PubMed)
(3) [Risk factors and development of metabolic disorders in workers of "Uralasbest" enterprise][Article in Russian] by Prianichnikova NI, Mazhaeva TV, Dubenko SÉ, Obukhova TIu, Chirkova IA.(PubMed)
(4) Metabolic Syndrome Prevalence by Race/Ethnicity and Sex in the United States, National Health and Nutrition Examination Survey, 1988–2012 by ORIGINAL RESEARCH — Volume 14 — March 16, 2017. (CDC)