Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Monday, 26 November 2018

Ginger, The Spice Which Protects Our Body Against Inflammatory Diseases

By Kyle J. Norton

Scientists may have found a pungent and kitchen spices which process a potential effect on the prevention and treatment of chronic inflammatory diseases without inducing any side effects.

Inflammation is a natural reaction of the immune system whose function is to protect our body against the invasion of the foreign stimuli and pathogens.

In the acute phase of tissue damage or injury, the white blood cells responsible for the first line of defense activate the production of the inflammatory cytokines to the site of infection with an aim to kill off the invasive agents.

However, in most cases, overproduction of inflammatory cytokines can damage the nearby cells and lead to improper healing with the formation of scars.

Chronic inflammation is an inflammation that lasts more than 3 months. The development and progression of chronic inflammatory diseases are the results of the immune system which can not kill off the invasive pathogens in the acute phase of infection or immune system mistakenly attacks the body tissue, leading to the persistently the low-grade inflammation.

In the further analysis of the evolution of physiological supersystems involved chronic inflammatory disease, Dr. Rainer H. Straub, the lead author said, "It is predicted that genes that protect energy stores are positively selected (as immune memory). This could explain why energy-demanding inflammatory episodes like infectious diseases must be terminated within 3–8 weeks to be adaptive, and otherwise become maladaptive:

These results suggested that the genes and networks used evolved during physiological supersystems, fitness consequences and during different life-history stages are positively selected if they serve acute, highly energy-consuming inflammation.

In other words, the immune system becomes maladaptive, if an inflammation does not terminate within eight weeks of infection.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The kitchen has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

On finding a natural ingredient for the treatment of inflammation without inducing any adverse effects, a joint study led by the CHA University, Seongnam was conducted to examine the molecular mechanism of 6-gingerol on adipocyte-mediated systemic inflammation in vitro and in high-fat-diet-induced obese zebrafish.

Injection of 6-gingerol exerted a significantly increased the production of anti-inflammatory cytokine interleukin-10 and decreased the expression of proinflammatory cytokines, TNFα, monocyte chemotactic protein-1, interleukin-1β, and interleukin-6.

In the RAW 264.7 macrophages, 6-gingerol inhibited the protein expression of proinflammatory factors TNFα and monocyte chemotactic protein-1, a small cytokine that belongs to the CC chemokine family.

6-Gingerol decreased c-JUN N-terminal kinase and I kappa B kinase beta which plays an important role in the inhibition of nuclear factor kappa-B kinase activated by multiple stimuli such as inflammatory cytokines

Where JNK (c-Jun N-terminal kinase) is a member of the MAPK (mitogen-activated protein kinase) family that regulates a range of biological processes including inflammation.

6-gingerol also decreased the expression of inducible nitric oxide synthase in the stimulation of the expression of inflammation.

Dr. Choi J, the lead scientists wrote in the final report, " 6-gingerol suppresses inflammation through the regulation of the c-JUN N-terminal kinase-I kappa B kinase beta and its downstream targets".

Furthermore, the investigation of the effects of 6-gingerol ((S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone) in experimental models that HepG2 cells were exposed to 500 µmol/l oleic acid (OA) for 24 h and preincubated for an additional 24 h with 6-gingerol (25, 50 or 100 µmol/l). 6-Gingerol (100 µmol/l) inhibited OA-induced triglyceride and inflammatory marker accumulation in HepG2 cells of non-alcoholic steatohepatitis also suggested that

* Daily application of 6ginger for 8 weeks while maintained on HFD. 6-Gingerol (100 mg/kg/day) alleviated liver steatosis, inflammation, and reversed

* [6]-gingerol also attenuated the expression of inflammatory cytokine genes and nuclear transcription factor-κB (NF-κB) increased in the HFD group.

The results strongly indicated 6-Gingerol attenuates HFD-induced steatohepatitis by downregulating NF-κB-mediated inflammatory responses and reducing hepatic lipogenic gene expression.

More interestingly, in the study includes five groups of rats containing 14 rats/group received corn oil (control), CPF (5 mg/kg), 6-GRF (100 mg/kg), CPF (5 mg/kg) + 6-GRF (50 mg/kg) and CPF (5 mg/kg) + 6-GRF (100 mg/kg) through gavage once per day for 35 days respectively, researchers showed that

* Before 6-gingerol application CPF-induced rats showed an increase in oxidative stress ((hydrogen peroxide (H2O2) and malondialdehyde (MDA)), inflammatory (myeloperoxidase (MPO), nitric oxide (NO) nitric oxide (NO) and tumor necrosis factor-α (TNF- α)), and apoptotic (caspase-3) markers.

* Injection of 6-gingerol attenuated all factors in the CPF induced rats.

* 6-GRF reduced the inflammatory expression through improving the activities of antioxidant enzymes catalase, superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione S-transferase (GST) as well as glutathione (GSH) level in the brain, ovary, and uterus of rats exposed to CPF.

Dr. Abolaji AO the lead author said, " the protective effects of 6-GRF on CPF-induced toxicity in the brain and reproductive organs of rats may be due to it's potent antioxidative, anti-inflammatory and antiapoptotic properties".

Where Chlorpyrifos (CPF) is an organophosphorus pesticide widely used in agricultural applications and household environments.

Taken all together, ginger processed abundantly 6-gingerol may be considered a functional kitchen spice for the prevention and treatment of inflammation.

Sources
(1) 6-Gingerol Suppresses Adipocyte-Derived Mediators of Inflammation In Vitro and in High-Fat Diet-Induced Obese Zebra Fish by Choi J1, Kim KJ1, Kim BH2, Koh EJ1, Seo MJ1, Lee BY. (PubMed)
(2) [6]-gingerol dampens hepatic steatosis and inflammation in experimental nonalcoholic steatohepatitis by Tzeng TF1, Liou SS1, Chang CJ1, Liu IM. (PubMed)
(3) Protective properties of 6-gingerol-rich fraction from Zingiber officinale (Ginger) on chlorpyrifos-induced oxidative damage and inflammation in the brain, ovary, and uterus of rats by Abolaji AO1, Ojo M2, Afolabi TT2, Arowoogun MD2, Nwawolor D2, Farombi EO. (PubMed)

Sunday, 25 November 2018

Tualang honey Protects the Oral Cells Against the Onset of Mouth Cancer With No Side Effects

Kyle J. Norton

Mouth/oral cancer is a medical condition associated with the irregular cell growth on the tissue of the mouth caused by genetic alteration of the cell DNA.

Most cases of mouth cancer start in the flat, thin cells (squamous cells) of the inner lining tissue that line the lips and the inside of the mouth.

According to the statistics provided by the American cancer society, in 2018, approximately, over 50,000 people will get oral cavity or oropharyngeal cancer. An estimated over 10,000 people will die of these cancers.in the United States.

The exact causes of mouth cancer are unknown. However, the increase in age, gender, exposure to radioactive, long-term use of tobacco use and excessive alcohol drinking, viral infection and genetic mutation are the most common prevalent risk factors found in people with mouth cancer.

Some researchers also suggested that people with immune system suppression due to the use of an immune suppressor are at the increased risk of the disease.

The Canadian Cancer Society in the explanation of how weakened immune system can induce mouth cancer, wrote, "Your immune system can be weakened after an organ transplant or treatment for an immune system disease. and "People with a weakened immune system have a higher risk of developing oral cancer, especially lip cancer".

Also, " The higher risk may be due to taking drugs that suppress your immune system. People with weakened immune systems are also more likely to get an HPV infection, which increases the risk of oral cancer"

If you experience symptoms of a sore that does heal within a few days, a growth, lump or thickening of the skin or lining of your mouth, tongue and jaw pain that do not heal in weeks, persistent sore throat, difficult or chewing and swallowing, please check with your doctor to rule out the possibility of mouth cancer.

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

On finding a natural ingredient or whole food for the treatment of t inducing mouth cancer without inducing any side effect compared to surgery followed by chemo and.or radiotherapy researchers at the Universiti Sains Malaysia examine the antiproliferative activity of local honey (Tualang) on OSCC cell lines.

The study procedures include several concentrations of Tualang honey (1% - 20%) were applied directly on OSCC cell lines for 3, 6, 12, 24, 48 and 72 hours.

The study also used MTT assay to assess the cell viability and the Annexin V-FITC Apoptosis Detection Kit.to detect the cell apoptosis.

Application of Tualang honey induced cancer cells apoptosis observed by cell degradation and reduced in numbers.

In other words, the apoptotic cellular changes like becoming rounded, reduction in cell number, blebbed membrane and apoptotic nuclear changes like nuclear shrinkage, chromatin condensation, and fragmented nucleus were observed through MTT assay.

The MTT assay also suggested that Tualang honey exerts an inhibitory effect in a time and dose-dependent manner.

The efficacy was also found in the 50% inhibitory concentration (IC50) for OSCC of 4%.

The maximum inhibition of cell growth of ≥80% was observed in the concentration at 15%.

Dr. Ghashm AA the lead scientist at the final report wrote, "Tualang honey showed the antiproliferative effect on OSCC...cell lines by inducing early apoptosis".

Taken altogether, Tualang honey may be considered a functional food for the prevention and combined with the primary medicine for the treatment of mouth cancer.

Due to the limitation of the above study, further data collection large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of Tualang honey anti-mouth cancer possibilities.

Sources
(1) Antiproliferative effect of Tualang honey on oral squamous cell carcinoma and osteosarcoma cell lines by Ghashm AA1, Othman NH, Khattak MN, Ismail NM, Saini R.(PubMed)

Black beans Protect Your Large Intestine Against Colon Cancer

By Kyle J. Norton

Black bean may have a profound effect in reducing and treatment of colon cancer, some scientists suggested.

The colon also known as the large bowel or large intestine, is the part of the digestive system in our body.

Colon cancer is a chronic condition caused by the cell growth irregularly and disorderly in the colon due to the alternation of DNA.

Most cases of colon cancer start in the cells on the surface of the inner lining of the colon. At this stage, patients may not experience any symptoms.

After penetrating deeper into the colon layer, the cancer cells may travel a distance away to infect other healthy tissue and organs through the fluids and blood circulation.

At this stage, the increased size of the tumor may suppress the nearby tissue, organs or nerves cells causing localized symptoms and severe pain.

Most common colon cancer metastasis are the lungs, liver.

According to the epidemiological studies, the most common risk factors of colon cancer are older

age, ethnicity, personal and family history of colorectal cancer or polyps, inflammatory intestinal conditions.

Particularly, people who follow the low-fiber, high-fat diet or have a sedentary lifestyle. are associated with the substantial risk for the onset of the disease.

Dr. Y J Cong, the lead author in the concerns of the sedentary behavior in risk of colon cancer in modern society, launched an investigation to examine the association of sedentary behavior with colon and rectal cancer.

The search of the databases of PubMed, Embase, and Google Scholar databases up to May 2013 to identify cohort and case-control studies that evaluated the association between sedentary behavior and colon or rectal cancer identified 23 studies with 63 reports included 4 324 462 participants.

After assessing the results of all the studies, the doctor team wrote. "Sedentary behavior is associated with an increased risk of colon cancer. Subgroup analyses suggest a positive association between sedentary behavior and risk of rectal cancer in cohort studies".

Black bean is a Small roughly ovoid legume with glossy black shells, genus Phaseolus, belonging to the family Fabaceae.

The bean can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

The major chemical compounds of black bean include anthocyanin, (-)-epicatechin, delphinidin, petunidin, flavonols, and malvidin.

On finding, a natural whole food for the treatment of colon cancer, researchers at the Tecnológico de Monterrey-Campus Monterrey conducted an investigation to examine the black bean antioxidant capacity and antiproliferative activity against cancer cell lines.

Flavonoids extracted from seed coats exerted a potential effect against colon cancer cell line'

The extracts obtained from seed coats after 3 and 5 germination days inhibited all cancer cell lines proliferation, including the tested colon cancer with no cytotoxicity against control cells.

Further analysis also suggested that flavonols and group B saponins isolated from the seed coat were more related to hepatic and colon cancers.

These results indicated that not all chemical compounds found in black bean have a potential effect in the inhibition of colon cancer. However, intake of the black bean as a whole food may have significant effects in reducing the risk of colon cancer.

Additionally, in the finding evidence to suggest an inverse relationship between bean consumption and colon cancer, researchers at the Food Science program at the Michigan State University conducted a study to determine whether consumption of black beans and/or navy beans would reduce colon carcinogenesis in rats.

Selected rat group were fed a modified AIN-93G diet (control) or diets containing 75% black beans or 75% navy beans for 4 wk, and then colon cancer was initiated by the administration of two injections of azoxymethane 1 wk apart.

At 31 wk after the second injection, the incidence of colon adenocarcinomas was significantly lower in rats fed the black bean (9%) than in rats fed the control diet (36%).

Total tumor multiplicity was also significantly lower in rats fed the black bean diet than in rats fed the control diet.

After taking into account co and confounders, Dr. Hangen L, the lead author said, "The 44-75% reduction in colon carcinogenesis in rats fed beans was attributed to 1) more controlled appetites, leading to significantly less body fat, and 2) much greater concentrations of butyrate in the distal colon".

These results suggested black beans only have a potential effect in lowering the risk of colon cancer. but also stop cells multiplicity in the case of colon cancer.

However, further data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of black bean anti-colon cancer possibilities.

References
(1) Differential accumulation of polyphenolics in black bean genotypes grown in four environments.
Marles MA, Balasubramanian P, Bett KE. (PubMed)
(2) Evaluation of the antioxidant and antiproliferative activities of extracted saponins and flavonols from germinated black beans (Phaseolus vulgaris L.).
Guajardo-Flores D, Serna-Saldívar SO, Gutiérrez-Uribe JA(PubMed)
(3) Consumption of black beans and navy beans (Phaseolus vulgaris) reduced azoxymethane-induced colon cancer in rats. by Hangen L, Bennink MR. (PubMed)
(4) Association of sedentary behavior with colon and rectal cancer: a meta-analysis of observational studies by bY J Cong,1 Y Gan,1 HL Sun,1 J Deng,1 S Y Cao,1 X Xu,1,2 and Z X Lu. (PubMed)

Herbal Cayenne, the Best Antioxidant Functional Fruit

By Kyle J. Norton

Herbal Cayenne may have a potential effect in stimulating the production of antioxidants from the host body to inhibit the overexpression of free radicals, some scientists suggested.

Free radicals are unstable molecules having an unpaired electron in the outer ring. in order for them to maintain stable, free radical must donate or steal an electron from another molecule, leading to a domino's chain reaction that cannot stop until inhibited by antioxidant or they are paired.

Antioxidants are stable molecules that inhibit the free radical oxidation and the unpaired electrons which are highly and chemically reactive in the human body.

Normally, expression of free radicals is neutralized by antioxidants produced by the host body enzymes. However, if the host antioxidant enzymes are suppressed, free radical can overexpress, leading to oxidative stress.

Overexpression of free radicals in initiating oxidative stress to the human body can cause oxidative damage to the cells, proteins, and DNA, the underlying factors in many chronic diseases, including type 2 diabetes, and cardiovascular disease.

Most common free radicals have been found to cause significant damage to DNA, proteins, carbohydrates, and lipids of the cell nucleus, and membranes are hydroxyl radical, superoxide anion radical, hydrogen peroxide, oxygen singlet, hypochlorite, nitric oxide radical, and peroxynitrite radical.

The causes of the production of free radicals are associated either from normal essential metabolic processes in the human body inducing diet or from external sources such as exposure to X-rays, ozone, cigarette smoking, air pollutants, and industrial chemicals.

People who follow the Western diet high in saturated and trans fat, red meat and processed foods ( high oxidation) and low in fruits and vegetable (low antioxidants) are susceptible to the overexpression of free radical or oxidative stress.

Truly, Fats and oils not can be oxidized during storage as a result of exposure to light, air but also can become oxidized, creating free radicals, if they are heated in high temperature, the main cooking style found in the Western diet.

Saturated fats are less likely than unsaturated fats to become oxidized. When cooking fats are reused, they become more oxidized and produce even more free radicals.

Cayenne is also known as Cayenne pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions.

The kitchen spice has been used in traditional medicine to increases metabolism, enhance circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises, and neuralgia, etc.

The chemical constituents of Cayenne include capsaicin, capsaicin oil, solaine, xanthenes, oleic acid, palmitic acid, etc.

In the investigation of the antioxidant activity, DPPH radical-scavenging activity correlated with total bioactive compounds (capsaicinoids, carotenoids, flavonoids, and total phenolics) in pepper cultivars, researchers at the Universidad Complutense de Madrid launched a study on the individual carotenoid and phenolic content as well as the antioxidant properties of four red-hot dried cultivars (Capsicum annuum L.).

Hot dried peppers at ripe stage demonstrated the high content of bioactive compounds that exhibited significant antioxidant properties (26-80 micromol Trolox equivalents/g of dry matter), compared to polyphenols >2000 mg/100 g of dry matter and carotenoids ranging from 95-437 mg/100 g of dry matter.

The amount released from the food matrix by the action of digestive enzymes was about 75% for total polyphenols, up to 49% for both beta-carotene and zeaxanthin, and up to 41% for beta-cryptoxanthin.

And, 50 to 80% of these carotenoids could reach the colon to be potentially fermented or could remain unavailable.

Furthermore, the study of sweet red bell pepper, one of the best sources of ascorbic acid and carotenoids and phenolic compounds important in the human diet, researchers emphasized that organic growing increased the level of antioxidant compounds such as carotenoids, phenolic compounds and vitamin C in sweet bell pepper, compared to conventional cultivated.

However, the second significant factor affecting the antioxidant compound content of sweet bell pepper was totally depending on the varieties.

Geography, climate change environment factors and time of harvest may also affect the antioxidant contents of the bell pepper.

Taken altogether, herbal cayenne processed a high amount of bioactive antioxidants may be considered a functional food for reducing the risk of oxidative stress-related diseases.

Due to numbers of an unknown factor which may affect the quality of the fruits, further data collection large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of herbal cayenne antioxidant possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Bioactive compounds of four hot pepper varieties (Capsicum annuum L.), antioxidant capacity, and intestinal bioaccessibility by Hervert-Hernández D1, Sáyago-Ayerdi SG, Goñi I.(PubMed)
(2) Characterisation of antioxidant compounds in sweet bell pepper (Capsicum annuum L.) under organic and conventional growing systems by Hallmann E1, Rembiałkowska E.(PubMed)

Herbal Aloe Vera Juice, the Potent Mouth Wash for Treatment of Oral Mucositis Caused by Chemo and Radiation Therapy in Patients with Head and Neck Cancer

By Kyle J. Norton

Aloe vera may have a potential effect in reducing the oral mucositis in patients with head and neck cancer, some scientists suggested.

Head and neck cancer is a class of cancers that start in the mouth, throat, larynx, sinuses, or salivary glands.

At the early stage, cells on the surface of the inner lining associated with head and neck start to grow irregularly and disorderly.

However, at the advanced stage, as cancer has penetrated into the deeper layers, patients may experience symptoms of a lump in the nose, neck or throat, with or without pain, a persistent sore throat that does not heal, trouble swallowing (dysphagia) and frequent and persistent coughing.

In some cases at the advanced stage, cancer cells may travel a distance away from the original site to infect other healthy tissue and organs.

Most common head and neck cancer metastases are secondary skin cancer.

Oral mucositis is one of the common side effects in cancer patients who are under chemo and radiation treatment, leading to symptoms of pain, nutritional problems as a result of an inability to eat, and increased risk of infection due to open sores in the mucosa.

The symptom has been found to reduce the quality of life of cancer patients.

According to The Oral Cancer Foundation, patients experience the side effect of oral mucositis after 5 to 10 days of chemotherapy. Normally, the side effect will disappear itself in short few weeks, depending on the types of medicine, doses, and duration of the treatment.

Dr. Begonya Chaveli-López, the lead author in the study "Treatment of oral mucositis due to chemotherapy" wrote, "Very few interventions of confirmed efficacy are available for the management of oral mucositis due to chemotherapy. However, according to the reviewed literature, the use of palifermin, cryotherapy and low power laser offer benefits, reducing the incidence and severity of oral mucositis".

On finding a natural and effective ingredient for the treatment of oral mucositis with no side effects, researchers examined the topical Aloe vera, a widely used for mild sunburn, frostbites, and scalding burns for its effect on mucositis.

Aloe gel showed the beneficial effects for wound healing, mucous membrane protection, and treatment of oral ulcers.

Application of Aloe gel also enhanced the anti-inflammatory, immunomodulation, antifungal, scavenging free radicals, increasing collagen formation and inhibiting collagenase, epidemiological studies suggested.

Oral Aloe vera mouthwash demonstrated a significant prevention of radiation-induced mucositis by its wound healing and anti-inflammatory mechanism.

The herbal mouthwash also reduced oral candidiasis of patients undergoing head and neck radiotherapy due to its antifungal and immunomodulatory properties.

These efficacies indicated that Aloe vera mouthwash may be considered an alternative potential for treating radiation-induced oral mucositis and candidiasis in patients with head and neck cancers.

Futhermore, in the finding the most effective agent for treatment of oral mucositis, the Haji Mirza Mohammad conducted a triple-blind, randomized controlled trial in the comparison of the Aloe vera mouthwash with a benzydamine mouthwash in the alleviation of radiation-induced mucositis in head and neck cancer patients.

The trial included 26 eligible head and neck cancer patients who were to receive conventional radiation therapy at the radiation oncology department were randomized to receive an Aloe vera mouthwash or a benzydamine mouthwash.

No difference in the distribution of mucositis severity between the two groups, at the baseline.

The mean interval between radiation therapy and the onset of mucositis was similar for both groups.

The mean interval between the start of radiation therapy and the maximum severity of mucositis were was also similar in both the Aloe vera and benzydamine groups (Aloe vera 23.38±10.75 days, benzydamine 23.54±15.45 days).

According to the comparison test researchers suggested that the Aloe vera mouthwash could be an alternative agent in the treatment of radiation-induced mucositis in patients with head and neck cancer due to its exertion of the similar effects as of those of beneficial as benzydamine mouthwash in alleviating the severity of radiation-induced mucositis with no side effects.

Taken altogether, herbal Aloe vera juice may be considered a functional juice for the treatment of the side effect of oral mucositis caused by chemo and radiation therapy in patients with head and neck cancer

Sources
(1) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(2) Potential prevention: Aloe vera mouthwash may reduce radiation-induced oral mucositis in head and neck cancer patients. by Ahmadi A.(PubMed)
(3) Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial by Sahebjamee M, Mansourian A, Hajimirzamohammad M, Zadeh MT, Bekhradi R, Kazemian A, Manifar S, Ashnagar S, Doroudgar K.(PubMed)

Saturday, 24 November 2018

White Button Mushroom Which Processes A Potential to Cure Fatty Liver Disease

By Kyle J. Norton

White button mushroom may have a protective effect against the onset and treatment nonalcoholic liver disease, some scientists suggested.

Fatty liver or hepatic steatosis is a disease caused by the buildup of fat in the liver. If the fat in your liver is over 5 percent proportional to the liver cells, you are considered to have the early stage of the fatty liver disease.

According to the American liver foundation, the fatty liver is the most common disease in the US, affecting over affecting around 25 % of the population. The disease is most common in the age group between 40 and 60.

The common diseases associated with the onset of the nonalcoholic fatty liver disease include obesity hyperlipidemia, or high levels of fats in the blood, especially high triglycerides, diabetes, and genetic inheritance.

However, some researchers also found that long-term use of certain medication is the prevalent risk factors of the fatty liver such as rapid weight loss side effects of certain medications, including methotrexate (Trexall), tamoxifen (Nolvadex), amiodarone (Pacerone), and valproic acid (Depakote).

Can the nonalcoholic fatty liver disease be prevented? Dr. William Nseir, the lead author in the study " Role of diet and lifestyle changes in nonalcoholic fatty liver disease", wrote, "there is no drug therapy that can be formulated for treating NAFLD. A combination of dietary modifications and increased physical activity remains the mainstay of NAFLD management" and

"NAFLD patients, whether obese or not, should be educated that a healthy diet and physical activity have benefits beyond weight reduction".

The result suggested that if you have followed a healthy diet high in fruits and vegetables, whole grain and low in saturated and trans fat, red meat and processed food and lifestyle accompanied by moderate exercise, you risk of nonalcoholic fatty liver disease is closed to zero.

If you are experiencing the symptoms of a persistently enlarged fluid-filled abdomen, jaundice of the skin and eyes, confusion and abnormal bleeding, please check with your doctor to rule out the possibility of fatty liver disease.

Mushroom is a standard name of white button mushroom, the fleshy, spore-bearing fruiting body of a fungus produced above ground on soil or on its food source,

It is a genus A. Muscaria and belong to the family Amanitaceae and has been cultivated in many cultures all over the world for foods and health benefits.

The chemical constituents of white button mushroom include
Astraodorol, Psilocybin, Lectin, adustin, ribonuclease, nicotine, 2-hydroxy-4-methoxy-6-methylbenzoic acid, orsellinic acid, melleolide, ergosterol, genistein, daidzein, daucosterol, genistin, uracil, and D-mannitol.

In the concerns of low estrogen production in the risk of nonalcoholic fatty liver disease in the menopause women, researchers at the cellular team at the Beckman Research Institute of the City of Hope launched an investigation to examine the effects of white mushroom in the groups of ovariectomized mice (a model of postmenopausal women).

Selected OVX mice were fed a high-fat diet supplemented with WBM powder before injection of white button mushroom to induce fatty disease pattern.

Application of white button mushroom (WBM) exerted a significantly protective effect against liver steatosis in ovariectomized (OVX) mice.

As dietary WBM intake significantly lowered liver weight and hepatic injury markers in OVX mice.

The pathological examination also suggested that WBM lowers fat accumulation in tissue in the livers of mice.

Furthermore, the glucose clearance ability of tested mice also improved substantially compared to untreated mice group.

According to the microarray analysis, genes associated to the fatty acid biosynthesis pathway, particularly the genes for fatty acid synthetase (Fas), a major determinant of the maximal hepatic capacity to generate fatty acids by de novo lipogenesis and fatty acid elongase 6 (Elovl6) which plays a key role in fat synthesis were down-regulated (reduced function).

Additionally, in vivo, the down-regulation of the expression of FAS and ELOVL6 in the HepG2 cell line by WBM extract was attributed to the inhibition of Liver X receptor (LXR) signaling and it's downstream transcriptional factor SREBP1c.

Where Liver X receptors (LXRs) are important regulators of cholesterol and fatty acid and SREBP-1c is associated with fatty liver and increased visceral fat mass.

The finding indicated that WBM is protective against hepatic steatosis and NAFLD in OVX mice as a model for postmenopausal women.

The study was published on October 25 on the US National Library of Medicine and National Institutes of Health. You can view the publication by clicking the link in the resources,

Taken altogether, white button mushroom may be considered a functional food for the prevention and treatment of nonalcoholic fatty liver disease.

References
(a) [Chemical constituents from fungus Armillaria mellea]. by [Article in Chinese] by Yuan XL1, Yan LH, Zhang QW, Wang ZM.(PubMed)
(1) Protective effects of white button mushroom (Agaricus bisporus) against hepatic steatosis in ovariectomized mice as a model of postmenopausal women by Kanaya N1, Kubo M, Liu Z, Chu P, Wang C, Yuan YC, Chen S.(PubMed)
(2) Role of diet and lifestyle changes in nonalcoholic fatty liver disease by William Nseir, Elias Hellou, and Nimer Assy. (PubMed)

Phytochemical Anacardic Acids, Kills Prostate Cancer Cells in Vivo and Vitro

By Kyle J. Norton

Anacardic acids may process a significant effect in reducing the risk and treatment of prostate cancer, some scientists suggested.

Prostate cancer is a chronic medical condition characterized by cell growth disorderly and uncontrollably in the prostate tissue.

Most cases of prostate cancer start on the cell of the surface of the prostate inner lining due to unknown mechanisms that alter the prostate cells DNA.

Most prostate cancers and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.

Prostate cancer is very slowly cancer.

The exact causes of prostate cancer are debatable.

People who were infected by the prostate cell change may not feel any symptoms until they are the age of 50 or over.

Aging, ethnicity, family history and hereditary breast and ovarian cancer (HBOC) syndrome associated with DNA-repair mutations to the BRCA1 and/or BRCA2 genes, exposure to toxic chemicals are the most common risk factors associated to the onset of the diseases.

However, most men who have some of the above risk factors do not develop prostate cancer.

Some researchers in the comparison of prostate cancer risk in men who follow different diets and lifestyle suggested, the risk of prostate cancer increased substantially in men who follow the Western diet high saturated fat and trans fat, red meat, and processed foods and low in fruits and vegetable and whole grains.

On the other hand, the risk of prostate cancer decreases in men who have followed the traditional diet.

Dr.Roberto Fabiani, the lead author at the University of Perugia, in the study "A Western Dietary Pattern Increases Prostate Cancer Risk: A Systematic Review and Meta-Analysis" said, " The Healthy pattern was not related to PC risk (OR = 0.96; 95% confidence interval (CI): 0.88–1.04) while the Western pattern significantly increased it (OR = 1.34; 95% CI: 1.08–1.65)".

Men who are at higher risk of prostate cancer due to family history and ethnicity may lower the risk by changing of diet pattern with more fruits and vegetable and less red meat and processed foods.

Anacardic acids are phenolic lipids, phytochemicals of the organic acid found abundantly in cashews, mangoes, etc..

In the study to reaffirm the anti-prostate cancer effect of Anacardic acid (6-pentadecylsalicylic acid), a natural inhibitor of histone acetyltransferase from Amphipterygium adstringens, researchers at the East China Normal University conducted an investigation to examine whether this salicylic acid could block angiogenesis.

Application of Anacardic acid significantly suppressed the vascular endothelial growth factor (VEGF)in the induction of prostate cancer cell proliferation, migration, and adhesion and capillary-like structure formation of primary cultured human umbilical vascular endothelial cells (HUVECs) without detecting cellular toxicity.

Anacardic acid also effectively inhibited vascular development in chick embryo chorioallantoic membrane ex vivo (n = 10) and VEGF-triggered corneal neovascularization in vivo.

In mice bearing human prostate tumor xenografts (n = 6-7), application of anacardic acid (2 mg/kg per day) inhibited the volume and weight of solid tumors through apoptosis.

Furthermore, application of anacardic acid retarded the prostate tumor cell proliferation and microvessel density.

Additionally, Anacardic acid (AA) as a mixture of 2-hydroxy-6-alkylbenzoic acid homologs also inhibited LNCaP cell proliferation, induces G1/S cell cycle arrest and apoptosis of LNCaP cell.

After taking into account co and confounders, researchers discovered that AA-induced the LNCaP cells apoptosis may be due to the following aspects
* AA can regulate p300 transcription and protein level against the processes of cell proliferation and differentiation.in LNCaP cells.

* AA can activate p53 through its function as a regulator of the cell cycle and a tumor suppression against LNCaP cells.

* AA can down-regulates androgen receptor (AR) through suppressing p300 in the development and progression of prostate cancer.

The results suggested that AA process multiple anti-tumor activities in LNCaP cells.

Taken altogether, Anacardic acids may be considered a functional phytochemical for the prevention of prostate cancer and combined with the primary therapy for the treatment of prostate cancer, without inducing any side effects, depending on the large and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Anacardic acid (6-pentadecylsalicylic acid) inhibits tumor angiogenesis by targeting Src/FAK/Rho GTPases signaling pathway by Wu Y, He L, Zhang L, Chen J, Yi Z, Zhang J, Liu M, Pang X.(PubMed)
(2) Anacardic acid (6-pentadecylsalicylic acid) induces apoptosis of prostate cancer cells through inhibition of androgen receptor and activation of p53 signaling by Tan J, Chen B, He L, Tang Y, Jiang Z, Yin G, Wang J, Jiang X.(PubMed)
(3) A Western Dietary Pattern Increases Prostate Cancer Risk: A Systematic Review and Meta-Analysis by Roberto Fabiani,1,* Liliana Minelli,2 Gaia Bertarelli,3 and Silvia Bacci. (PMC)