Cinnamon, The Miracle Remedy Which Processes Anti Type 2 Diabetes Potency

Kyle J. Norton. Master of Nutrition


The causes of type 2 diabetes are debatable as researchers do not know why some people are susceptible to develop insulin resistance while others do not.

However, genetics, unhealthy diet and lifestyle are the most common risk factors of type 2 diabetes(8).

Some researchers suggested that racial/ethnic group, overweight/obesity, elevated blood pressure, elevated casual blood glucose, and the presence of acanthosis nigricans)  are associated to the development of type 2 diabetes mellitus (T2DM)(9). 

If untreated, patients with type 2 diabetes may develop potential complications of heart disease.neuron, kidney, eye, foot, skin damage.

In some cases, these patients may be infected by plaques accumulated in neurons, leading to Alzheimer's disease.

According to 2015 statistic, in US, approximately 30.3 million Americans, or 9.4% of the population, had diabetes, including  1.25 million children and adults have type 1 diabetes.

Unfortunately, according of Center of Diseases Control (CDC), over 7.2 million people have diabetes but remain undiagnosed, while another 84.1 million adults 18 years and older have prediabetes.

Continuously, the CDC wrote, " The estimated diabetes cost in the United States in 2012 was $245 billion, including $176 billion for direct medical costs and $69 billion in indirect costs, such as disability, time lost from work, and premature death".

Cinnamon, a kitchen spicy in many cultures, may have gained many believers, including medical professions because of its anti diabetic effect, through regulating the blood glucose levels in healthy and diabetic subjects.

According to herbalists, intake of 1/4 tsp. in the morning and evening may reduce the blood sugar significantly with little or no adverse side effects.

The herb has been use in herbal and traditional medicine as anti-fungal and bacteria level to improve reproductive organ, prevent flatulence and intestinal cramping, treat indigestion, diarrhea, bad breath, headache, migraine, etc.(1).

In a total of 66 patients with type 2 diabetes study conducted by Xuhui District Central Hospital, researchers showed that cinnamon reduces significantly blood triglyceride levels even in the low-dose group, after 3 months of oral administration(2)

Its extract also improved fasting blood glucose levels and glucose tolerance without altering the insulin secretion, through lower triglyceride and increased liver glycogen content and improved insulin action in liver tissues(3).

Dr. Kim SH and Dr. Choung SY. told PubMed that “The effect of cinnamon in significantly increases insulin sensitivity, reduces serum, and hepatic lipids, and improves hyperglycemia and hyperlipidemia possibly by regulating the PPAR-medicated glucose and lipid metabolism”(4)

In support of the above, chromium(Cr) and polyphenols found in cinnamon(Cinnamomon cassia)  in patients with type 2 diabetes expressed an strong improvement of glucose, insulin, cholesterol and HbA1c following Cr supplementation, in a double-blind placebo-controlled study(7).

Unfortunately, according to the Western University of Health Sciences, consumption of cinnamon is associated with a statistically significant decrease of levels of fasting plasma glucose, but insisted that high degree of heterogeneity may limit the ability to apply these results to patient care, due to the unclear preferred dose and duration of therapy(5)

The randomized clinical trial in which 70 Patients with type II diabetesassigned randomly two groups (35 in cinnamon and 35 in placebo group for the testing of the effect of cinnamon on the glucose level in blood, also indicated an insignificant effect of using cinnamon on glucose level of diabetic patients and the herb should not be recommended to patients with type II diabetes(6).

Taken altogether, cinnamon in low dose may be effective in controlling the levels of blood glucose in patient with diabetes without altering the insulin level. according to DR. Georgakopoulou EA(7).

Oral intake of Cinnamon may cause Stomatitis, and burning sensation in mouth with large amount. The traditional Chinese medicine also insisted that Overdoses of cinnamon can be toxic and damaged to liver(1).

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Author biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

References
(1) @Popular Herbs -Cinnamon
(2) Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes by Lu T, Sheng H, Wu J, Cheng Y, Zhu J, Chen Y.(PubMed)
(3) Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity by Sartorius T1, Peter A2, Schulz N3, Drescher A2, Bergheim I4, Machann J5, Schick F6, Siegel-Axel D2, Schürmann A3, Weigert C1, Häring HU1, Hennige AM(PubMed)
(4) Antihyperglycemic and antihyperlipidemic action of Cinnamomi Cassiae (Cinnamon bark) extract in C57BL/Ks db/db mice by Kim SH1, Choung SY.(PubMed)
(5) Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis by Allen RW1, Schwartzman E, Baker WL, Coleman CI, Phung OJ.(PubMed)
(6) The Effect of Cinnamon on Glucose of Type II Diabetes Patients by Hasanzade F1, Toliat M2, Emami SA3, Emamimoghaadam Z(PubMed)
(7) Chromium and polyphenols from cinnamon improve insulin sensitivity by Anderson RA.(PubMed)
(8) Risk factors contributing to type 2 diabetes and recent advances in the treatment and prevention by Wu Y1, Ding Y1, Tanaka Y2, Zhang W(PubMed)
(9) The Presence of Risk Factors for Type 2 Diabetes Mellitus in Underserved Preschool Children by Montgomery M1, Johnson P2, Ewell P(PubMed)

Green Tea and Its Bioactive Epigallocatechin-3-gallate (EGCG) That Gobble Up Herpesvirus

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in inhibited herpesvirus, some scientists suggested.

Herpesvirus is a large family of DNA viruses that cause diseases depending to types of viral infection.

According to viral classification, there are 8 types of herpesvirus, including human herpesvirus 1 that causes cold sores around the mouth. and 2 that causes genital herpes, herpes zoster that causes chickenpox and shingles, Epstein-Barr virus that causes infectious mononucleosis, cytomegalovirus (CMV) that causes mononucleosis, Human herpesvirus 6 and 7(HHV6 - 7) that causes roseola and Human herpesvirus 8 (HHV8) that causes cancer, such as Kaposi's Sarcoma.

According to statistic, in the United States, half of teens and adults under age 50 are still infected with the oral herpes virus, and about 1 in 8 have an infection with the genital herpes virus.

All herpesviruses like other virus are nuclear-replicating, infecting healthy cells nucleus through replication of viral DNA and transcription of viral mRNA.

People infected by may experience symptoms.of painful sores in the genital area, anus, buttocks, thighs, itching, painful urination, vaginal discharge,..... and tender lumps in the groin.

However, some people may not show any symptoms at all and sometimes, the diseases may be misdiagnosed as a skin condition.

Sadly, many people have blisters and sores that come back after the first herpes attack goes away.

Green tea is a precious drink processed numbers of health benefit known to almost everyone in Asia and the Western world.

In the study of green tea Epigallocatechin gallate (EGCG bioactive component against researchers found that
EGCG and other purified green tea catechins as topical agents inactivate multiple clinical isolates of HSV-1 and HSV-2(1). 

Application of EGCG in 10 to 20 min and reduced HSV-1 titers by the same amount in 30 to 40 min reduced HSV-2 titers by ≥1,000-fold(1).

Dr. Charles E, the lead scientists said, "(The efficacy in ameliorated risk of HSV), because EGCG would be able to directly inactivate extracellular HSV virions in the vaginal lumen" and " At a concentration range that can easily be delivered to the female reproductive tract".

Interestingly, in the study of Epigallocatechin-3-gallate (EGCG) effects on primary effusion lymphoma (PEL), an aggressive neoplasm caused by human herpesvirus 8 (HHV8), researchers found that EGCG inhibits induced cell death and ROS generation in PEL cells in a dose-dependent manner(2).

Furthermore, application of EGCG reduced the production of progeny virus from PEL cells without causing HHV8 reactivation(2). 

These results suggest that EGCG may have a therapeutic treatment of HHV8 infection and HHV8 that cause lymphomas.

Most importantly, according to the joint study conducted by the Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, epigallocatechin-3-gallate (EGCG), processed significant anti-infective properties. EGCG exerted different modes of action in inhibited the diverse families of viruses(3)

In details(3), EGCG 

* inhibited HCV through viral entry by interference with binding to target cells.
* Inhibited integrase, an enzyme produced by a retrovirus HCV by binding to envelope and CD4 and interference.
* Reduced HBV antigen expression, extracellular HBV DNA and cccDNA
* Induced damage and inactivation of virions of HSV-1/HSV-2, probably by binding to envelope proteins
* Inhibited EBV transcription of immediate-early genes Rta, Zta, and EA-D
* Inactivated Adenovirus particles, inhibited Adenovirus intracellular virus growth and viral protease
* Alternated influenza virus physical integrity of virus particles, inhibited entry by binding to haemagglutinin
* Suppressed enterovirus replication via modulation of cellular redox milieu

Taking all together, green tea and its bioactive constituents may be used in combined with conventional medicine for the prevention and treatment of herpesvirus. 

However, further data collection on large example size and multi-centers studies performed with human consumption of the green tea and its bioactive polyphenol epigallocatechin 3-gallate (EGCG), during the course of herpesviral infection will be necessary to complete the picture of their anti herpesviral possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Epigallocatechin Gallate Inactivates Clinical Isolates of Herpes Simplex Virus by Charles E. Isaacs, Guang Y. Wen, Weimin Xu, Jun Hua Jia, Lisa Rohan, Christopher Corbo, Vincenzo Di Maggio, Edmund C. Jenkins, Jr., Sharon Hillier(PubMed)
(2) Epigallocatechin-3-Gallate Suppresses Human Herpesvirus 8 Replication and Induces ROS Leading to Apoptosis and Autophagy in Primary Effusion Lymphoma Cells by Tsai CY1, Chen CY2, Chiou YH3, Shyu HW4, Lin KH5, Chou MC6, Huang MH7, Wang YF(PubMed)
(3) Anti-infective properties of epigallocatechin-3-gallate (EGCG), a component of green tea by Steinmann J1, Buer J, Pietschmann T, Steinmann E(PubMed)

Green Tea Mixture (NM) Which Kills 100% of Hemangioendotheliomas Cells, Biomedical Literature Suggest

Kyle J. Norton, Master of Nutrition

Green tea may have a therapeutic and positive effect in reduced development of hemangiomas, some scientists suggested.

The results were carried out by some respectable intistutes including the Dr. Rath Research Institute and published on online medical literature.

Hemangioma is a benign tumor formed by a collection of excess blood vessels. The disease is a birth mark usually growth during the first year of life, and recedes over time. 

Hemangioendotheliomas are chronic condition caused by abnormal growth of blood vessel cells, with no exact underlying cause. The disease is a rare vascular tumor, described for the first time in 1975 by Dail and Liebow as an aggressive bronchoalveolar cell carcinoma.

The disease most commonly affect the soft tissues, liver, lungs and bones.

Localized epithelioid hemangioendothelioma can be removed surgically.

Patients with hemangioendothelioma may induce symptoms weight loss. localized pain and swelling in the tumor area, red or blue skin nodules,..... and  infectious organs enlargement.

If you experience some of above symptoms, please check with your doctor right the way to rule the possibility.

Green tea, is a precious drink processed numbers of health benefit known to almost everyone in Asia and Western world.

In differentiation of the efficacy of a nutrient mixture (NM) containing lysine, proline, ascorbic acid and green tea extract against the development of hemangiomas researchers at the Dr. Rath Research Institute, conducted a experiment using mouse in hemangioendothelioma model injected by Matrigel.

NM had shown a significant effect in inhibited hemangioendothelioma cell proliferation and cell division, in vitro through evaluating cell viability, MMP secretion, invasion, morphology and apoptosis.

Athymic nude mice, 5-6 weeks old, inoculated with 3 x10(6) EOMA cells subcutaneously and randomly divided into two groups,
* Group A was fed with a regular diet and
* Group B was fed with a regular diet supplemented with 0.5% NM.

At the end of the experiment, researchers found that mice fed with NM inhibits 50% of tumors growth.

Further analysis suggested that the efficacy of NM in inhibited the growth of tumor was attributed to its cytotoxicity linearly in induced apoptosis of EOMA cells, in dose dependent manner.

Injection of Matrigel in induction of tumor was inhibited by green tea mixture at 50, 100 and 500 microg/ml by 25%, 30% and 100% respectively

Dr. Roomi MW, the lead author, after taking into account of other co and con founders said, " NM may have therapeutic potential in treating infantile hemangioendotheliomas and, perhaps, other cutaneous vascular tumors".

Taken together, green tea mixture NM may have a profound effect in reduced risk and treatment of hemangioendotheliomas.

However, further data collection on large example size and multi centers studies performed with human consumption of green tea and its bioactive phytochemicals, during the course of the condition will be necessary to complete the picture of their anti hemangioendothelioma possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Antiangiogenic properties of a nutrient mixture in a model of hemangioma by Roomi MW1, Kalinovsky T, Niedzwiecki A, Rath M.(PubMed)

* 13 Health Benefits of Green Tea Bioactive Polyphenols Gallocatechin (GC), According to Medical Publication Online

By Kyle J. Norton

Green tea contains more amount of antioxidants than any drinks or foods with the same volume, and is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China.

Gallocatechin, containing catechin is phytochemicals of Flavan-3-ols, in the group of Flavonoids (polyphenols), found abundantly in green tea, almonds, black diamond plums, black tea, cocoa beans, Fuji apples, golden delicious apple, etc.


1. Bone metabolism
In the investigation of three tea catechins, epigallocatechin (EGC), gallocatechin (GC), and gallocatechin gallate (GCG) for their effects on bone metabolism, researchers found that EGC significantly inhibit osteoclast formations from RAW 264.7 cells upon receptor activation of nuclear factor-kappaB ligand induction on the fourth day of treatment, at a concentration of 10 microM(1).

Receptor activator of nuclear factor (NF-kappaB) ligand (RANKL) is the essential factor for osteoclast formation, fusion, activation, and survival, thus resulting in bone resorption and bone loss.

EGC also at dose-dependently inhibited the mRNA expression of tatrate-resistant acid phosphatase(1) which plays a critical role in many biological processes including skeletal development, collagen synthesis and degradation, the mineralisation of bone(14),
Further more, GC and GCG could decrease osteoclastogenesis at 20 microM.

Dr. Chun Hay Ko, the lead author said, "tea catechins, EGC in particular, had positive effects on bone metabolism through a double process of promoting osteoblastic activity(bone formation) and inhibiting osteoclast differentiation(bone re absorption)"(1).


2. Antimetastatic effects
In the evaluation of the antimetastatic effects of P urinaria L extracts (PUE), containing polyphenols including gallic acid, methyl gallate, epicatechin, epigallocatechin-3-gallate, gallocatechin-3-gallate, rutin, epicatechin-3-gallate, and naringin, researchers found that PUE inhibits the transcription of  of MMP-2 osteoblasts  that regulates osteopontin and bone protein expression in bone metastasis of osteotropic cancers(2).

Further more, PUE also exerted an inhibitory effect on the DNA-binding activity and the nuclear translocation of NF-κB and AP-1 in induction of secondary cancer and growth of LLC cells in vivo(2)


"(These results suggested that) PUE could be applied applied to be a potential antimetastatic agent", Dr. Tseng HH, the lead scientists at the Antai Tian-Sheng Memorial Hospital said(2).

3. Anti skin cancer
In the determination of the effect of green tea catechins on the invasive potential of human melanoma cells and the molecular mechanisms underlying these effects using A375 (BRAF-mutated) and Hs294t (Non-BRAF-mutated) melanoma cell lines in vitro model, researchers found that application of green tea catechins inhibits melanoma cell migration, through transition of mesenchymal stage to epithelial stage in induction of tumor growth to advanced stage(3).

These results indicate that EGCG, a major green tea catechin, has the ability to inhibit melanoma cell invasion/migration, an essential step of metastasis, by targeting endogenous expression of COX-2, which plays an important role in increased production of PGE2, the hormone that modulates skin caner cell proliferation from epithelial-to-mesenchymal transition(3).

4. Antidiabetic activity
In the observation of Terminalia sericea stem bark extract and theirs effect against alpha-glucosidase and alpha-amylase enzymes, four known compounds namely beta-sitosterol (1), beta-sitosterol-3-acetate (2), lupeol (3), and stigma-4-ene-3-one (4), in addition to two inseparable sets of mixtures of isomers [epicatechin-catechin (M1), and gallocatechin-epigallocatechin (M2). scientists found that  1 and 3 show the best inhibitory activity on alpha-glucosidase (IC50:54.5 and 66.5 microM) located in the brush border of the small intestine with function in stimulated digestion of carbohydrates that facilitates onset of diabetes mellitus type 2(4).

Bio-evaluation of the inhibitory activity of the purified compounds on alpha-amylase showed that 3 and 1 exhibit IC50 values of 140.7 and 216.02 microM, respectively against alpha-amylase, a protein enzyme that -links polysaccharides in induction of glucose and maltose with no side effects(4).

5. Anti-uveal melanoma and cancers activity
In the study of  the new compound gallocatechin 5-O-gallate isolated to MeOH extract of Acacia nilotica pods, scientists found that the newly found compound exerts a significant effect in inhibited uveal melanoma, a cancer (melanoma) of the eye involving the iris(5).

Further more, the antiproliferative activities of the isolated compounds and the related compound epigallocatechin 3-O-gallate (EGCG) also have a profound effect in protected healthy cells against the development of cutaneous melanoma, ovarian cancer, glioblastoma and normal retinal pigmented cells(5).


6. Degenerative diseases
In the investigation of whether green tea and its components can regulate the osteogenic and adipogenic differentiation in pluripotent rat mesenchymal stem cells (MSCs)in MSCs isolated from the bone marrow of tibiae and femora in rat, researchers found that among six tested tea polyphenols, epigallocatechin (EGC) processes the most effective in promoting osteogenic differentiation.

At 20 μM, EGC increased ALP levels and Ca deposition significantly in promote bone denesity by 2.3- and 1.7-fold, respectively,

When compared with the control group. EGC also increased the mRNA expression of bone formation markers runt-related transcription factor 2, ALP, osteonectin, and osteopontin(6)

7. Antioxidants
In the identification of glucose-6-phosphate dehydrogenase (G6PD) and its important roles in the maintenance of cellular redox balance, researchers found that pretreatment with green tea polyphenol epigallocatechin-3-gallate (EGCG) effectively blocks peroxynitrite-induced glutathione depletion(antioxidant enzyme in the host), p53 accumulation in suppressed irregular cell growth and  apoptosis in both normal and G6PD-deficient cells(7).

EGCG, administered to cells alone or as pretreatment, caused activation of protein kinase B (PKB), also known as Akt, that plays a key role in multiple cellular process in promoted survival and growth in response to extracellular signals.

The protective effect was abolished by phosphatidylinositol 3-kinase (PI3K) inhibitors, wortmannin, and LY294002, a steroid metabolite with function as immune suppressors(7).

8. Anti HIV
In the investigation of Epigallocatechin gallate (EGCG), the most abundant catechin in green tea and its effect on HIV-1, scientists found that EGCG appears to act mainly as an allosteric reverse transcriptase inhibitor with mechanisms different from those of currently approved NNRTIs used in the treatment of human immunodeficiency virus (HIV)(8).

Thus, EGCG is a good candidate for use as an additional or supportive anti-HIV agent derived from natural plants, according to "Epigallocatechin gallate inhibits the HIV reverse transcription step" by Li S, Hattori T, Kodama EN.(8)

9. Anti inflammatory activities
In the evaluation of the radioprotective efficacy of green tea polyphenols and the component ingredients against irradiated-induced damage in mice and elucidate the underlying mechanisms,  researchers found that GTP and its bioactive components (catechin, epigallocatechin and epigallocatechin-3-gallate) assists in decreasing the leukocytopenia, disease that decreases number of white blood cells (leukocytes) found in the blood(9).

Injection of GTP and its bioactive components, significantly reduced the elevated serum inflammatory cytokines (TNF-α, IL-1β, and IL-6)(9).

These results suggested that green tea polyphenols have a potential to be developed as radioprotective agents against irradiated-induced toxicity(9).

Furthermore, the antioxidant and anti-inflammatory activities of GTP can be attributed to the interaction of the different components through multiple and synergistic mechanisms.

10. Anti microbial effects
In the evaluation of the anti-inflammatory and antimicrobial effect of nanocatechin on CBP and plasma concentration of catechins in an animal model, researchers showed that the use of ciprofloxacin, catechin, and nanocatechin statistically significant decrease in bacterial growth and improvement in prostatic inflammation compared with the control  and catechin group..

Plasma concentrations of epicatechin, gallocatechingallate, and epigallocatechin gallate, were significantly higher in the nanocatechin group than those in the catechin group.

These results suggest that nanocatechin has better antimicrobial and anti-inflammatory effects on rat CBP than catechin due to higher absorption into the body(10).

11. Ultraviolet B irradiation protection
In the investigation of the protective effect of epigallocatechin gallate (EGCG) on the immune function of dendritic cells (DCs) after ultraviolet B irradiation (UVB), scientists found that the inhibition rate of DCs was improved to some extent after treatment with 200 microg/mL of EGCG.

UVB showed no significant influence on the secretion of IL-10 and IL-12 from DCs, while EGCG was able to down-regulate the secretion level of IL-12 and up-regulate that of IL-10.(11).

12. Antiviral effect
In the identification of tea polyphenols ability to inhibit enterovirus 71 (EV71) replication in Vero cell culture, researchers found that the viral inhibitory effect correlated well with the antioxidant capacity of polyphenol(12).

Mechanistically, EV71 infection led to increased oxidative stress, as shown by increased dichlorofluorescein and MitoSOX Red fluorescence(12).

Upon EGCG treatment, reactive oxygen species (ROS) generation was significantly reduced.

Consistent with this, EV71 replication was enhanced in glucose-6-phosphate dehydrogenase deficient cells, and such enhancement was largely reversed by EGCG(12).
.
13. Neuroprotective effect
In the research of beta-Amyloid (Abeta) peptide, a major component of senile plaques that play a crucial role in the development and neuropathogenesis of Alzheimer's disease (AD), researchers found that EGCG may have preventive and/or therapeutic potential in AD patients by augmenting cellular antioxidant defense capacity and attenuating Abeta-mediated oxidative and/or nitrosative cell death(13).

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources

(1) http://pubs.acs.org/doi/abs/10.1021/jf901545u
(2) http://www.ncbi.nlm.nih.gov/pubmed/22144737
(3) http://www.ncbi.nlm.nih.gov/pubmed/22022384
(4) http://www.ncbi.nlm.nih.gov/pubmed/22224265
(5) http://www.ncbi.nlm.nih.gov/pubmed/21903153
(6) http://www.ncbi.nlm.nih.gov/pubmed/21877759
(7) http://www.ncbi.nlm.nih.gov/pubmed/16506813
(8) http://www.ncbi.nlm.nih.gov/pubmed/21730371
(9) http://www.ncbi.nlm.nih.gov/pubmed/21498061
(10) http://www.ncbi.nlm.nih.gov/pubmed/20694569
(11) http://www.ncbi.nlm.nih.gov/pubmed/19735514
(12) http://www.ncbi.nlm.nih.gov/pubmed/21903153
(13) http://www.ncbi.nlm.nih.gov/pubmed/19557365
(14) https://www.ncbi.nlm.nih.gov/pubmed/18365835

* Carrot and Its Bioactive Chemical Compounds in Reduced Risk and Treatment of Colon Cancer

Kyle J. Norton, Master of Nutrition

Carrots may have a profound and positive effect in reduced risk, progression and treatment of colon cancer, some scientists suggested.

Colon cancer is a chronic condition characterized by irregular cell growth in the colon tissue. At the later stage, the cancerous cells may travel a distance away from the original site to infect other healthy tissue and organs.

As of today, researchers do not know what cause colon cancer. However, certain risk factors, such as genetic mutations that induce healthy DNA change are associated to increase risk of cancer.

Some researchers suggested that unhealthy diet  and life style such as American diet  with high intake of red meat, low intake of fiber, low intake of calcium, cigarette smoking,.... and obesity are the prevalent risk factors of colon cancer(4).

And increase consumption of a wide variety of fruit and vegetable, particularly, dark-green leafy, cruciferous, a deep-yellow on tones, and fibre are convincing preventive factors(5).

Dr. Corrêa Lima MP, the lead author at the Mato Grosso Federal University said, " lifestyle modification including proper diet such as the ones rich in vegetable and poor in red meat and fat, regular physical activity and maintaining an appropriate body weight and avoiding the use of tobacco and alcohol may lead to reduce colorectal cancer risk"(5).

Patients in early stage colon cancer may experience gastrointestinal symptoms of changes in your bowel habits, constipation. diarrhea or alternating diarrhea and constipation. Some patients may also develop symptoms of  from rectal bleeding or blood in your stool, abdominal bloating,.... and cramps or discomfort.

Truly, some chronic conditions and medicine use for treatments also were found to increased risk of colon cancer, including diabetes, acromegaly, a growth hormone disorder, ,,, and radiation treatment for other cancers.

In US, colorectal cancer is the third most common cancer diagnosed in both men and women. 

According to statistic of American Cancer Society, in 2018, approximately, 97,220 new cases of colon cancer.and 43,030 new cases of rectal cancer.are diagnosed in US. Colorectal cancer also causes death of 50,630 during 2018(6).

Carrot, a root vegetable with orange color is a sub spices of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

According to the study to determine the anticancer activity of the pentane fraction (F1) and the 1:1 pentane:diethyl ether fraction (F2) isolated from Daucus Carota oil extract (DCOE) against human colon adenocarcinoma cell lines (HT-29 and Caco-2), application of various concentration of both extracts exerted significant inhibitory effect against proliferation and induced apoptosis through numbers of factors.

The observation by Western blot revealed that the activity of F1 and F2 constrict the tumors expansion through activation of caspase-3, the key protein facilitators with function to execute apoptosis or program cell death and PARP cleavage, with function in stimulated various pathological cell death processes.  

Further analysis also suggested that F1 and F2 inhibited the cell death processes through increased levels of Bax expression in initiated pro-apoptotsis involved in a wide variety of cellular activities and p53 in regulated cell cycle as a tumor suppressor.

Together, both injections also deceased levels of Bcl-2 with function in inhibited tumor cells apoptosis.

Moreover, treatment of HT-29 cells with either fraction markedly also induced cell adhesion, cell cycle progression, cell migration, cell apoptosis through decreased the levels of both phosphorylated Erk and Akt.

Activation of oncogenic signalling proteins AKT and ERK by phosphorylation has an established role in the development of certain types of cancer(7).

Additionally, in mice model, β-2-himachalen-6-ol (HC) isolated from the Daucus carota oil extract st the concentration of 1, 5, 10 and 25 μg/ml, were also found to inhibit numbers of cancers, including colon cell progression.

In SW1116 colon cancer cell lines, injection of β-2-himachalen-6-ol (HC) demonstrated a significantly inhibitory activity in a dose-dependent in decreased cell survival with an IC50 of 18 and 14.5 μg/ml after 24 and 48 h respectively.

According to the Flow cytometry analysis, at concentration of 10 μg/ml, HC increased the number of tumors cells undergoing necrosis of 18.05% and 58.01% and late apoptosis of 15.66% and 30.47%, respectively.

These results suggested that β-2-himachalen-6-ol (HC) induced cancer cell apoptosis and cancer growth restriction, linearly in doses dependent manner.

Additional differentiation also suggested the application exerted anti colon cancers cell line effect through similar proteins and pathways as mentioned in the first study.

Most importantly, β-2-himachalen-6-ol (HC) in inhibited colon cancer cell line through cytotoxicity in cell cycle arrested without causing harm to the nearby health cells.

The above illustration were also supported by the investigation of beta-carotene and lycopene, a bioactive phytochemical found in carrot in a modify luminal process relevant to colon carcinogenesis conducted by the Technical University of Munich.

According to the randomized cross-over trial of twenty-two healthy young men on a low-carotenoid diet consumed 330 ml tomato or carrot juice per d for 2 weeks, consumption of carrot juice led to a marked increase of beta-carotene and alpha-carotene in faecal water with high dose-dependent cytotoxic and anti-proliferative effects on colon adenocarcinoma cells (HT29).

Taken together, carrot and its bioactive compounds may be considered as function food in ameliorated risk and increased efficacy of conventional medicine for treatment of colon cancer.

However, further data collection on large example size and multi centers studies performed with human consumption of the carrot and its bioactive phytochemicals, during the course of the disease will be necessary to complete the picture of their anti colon cancer possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Daucus carota Pentane-Based Fractions Suppress Proliferation and Induce Apoptosis in Human Colon Adenocarcinoma HT-29 Cells by Inhibiting the MAPK and PI3K Pathways by Shebaby WN1, Bodman-Smith KB1, Mansour A2, Mroueh M3, Taleb RI4, El-Sibai M4, Daher CF4.(PubMed)
(2) Effects of carrot and tomato juice consumption on faecal markers relevant to coloncarcinogenesis in humans by Schnäbele K1, Briviba K, Bub A, Roser S, Pool-Zobel BL, Rechkemmer G.(PubMed)

(3) Antitumor activity of β-2-himachalen-6-ol in colon cancer is mediated through its inhibition of the PI3K and MAPK pathways by Daaboul HE1, Daher CF2, Bodman-Smith K1, Taleb RI2, Shebaby WN2, Boulos J2, Dagher C3, Mroueh MA4, El-Sibai M5.(PubMed)
(4) Lifestyle Factors and Their Combined Impact on the Risk of Colorectal Polyps by Zhenming Fu, Martha J. Shrubsole, Walter E. Smalley, Huiyun Wu, Zhi Chen, Yu Shyr, Reid M. Ness, and Wei Zheng(PMC)
(5) Colorectal cancer: lifestyle and dietary factors by Corrêa Lima MP1, Gomes-da-Silva MH(PubMed)
(6) Key Statistics for Colorectal Cancer by American Cancer Society
(7) ERK and AKT phosphorylation status in lung cancer and emphysema using nanocapillary isoelectric focusing by Crosbie PA1, Crosbie EJ2, Aspinall-O'Dea M3, Walker M3, Harrison R4, Pernemalm M5, Shah R6, Joseph L7, Booton R8, Pierce A3, Whetton AD(PubMed)

* Surprise You? Learn How Traditional Chinese Medicine (TCM) Differentiate and Treat Bladder Cancer

Kyle J. Norton

Bladder cancer occurs when cells mass in the inner lining of the bladder form a malignant growth, or tumor. In other words, bladder cancer is a medical condition caused by irregular growth of cells in bladder tissue.

The seriousness of the condition is depending on the penetration of cancerous cells.. At the early stage, the cancerous only are found on the surface of the bladder.

However, at the later stage, the uncontrollable cells may travel a distance away  from the bladder to infect other healthy cells and tissue of other organs through bloods and fluids circulation, such as the prostate gland in men or uterus in women.

Symptoms(1)
1. Traditional Chinese medicine indicated that urinary with blood is one of the first symptom discovered by bladder cancer patient. Sometimes, red blood cells can be viewed by naked eyes but most of the times, it requires a blood test.
2. Back pain
3. Fluid retention in the kidney
4. Fever
5. Other symptoms are similar to the conventional medicine.
Most patient with early bladder cancer my experience blood in urine with no pain at all.

Risk Factors(1)
1. Occupation
Occupation required to contact with chemical toxins daily and over a prolonged period of time have a high risk of bladder cancer. Most workers do not experience any symptom of bladder cancer until later in their life. We are taking about the period over 30 years.

2. Smoking
Cigarette contains certain harmful chemicals which can cause cancer. In China, due to social culture difference, the risk of male and female with bladder cancer is 41%, 30% accordingly.

3. Age
The risk of bladder cancer increases with age. The older you are, the higher the risk.

4. Sex
The risk of bladder cancer of male is 4 time higher than women

5. Race
Certain race are high risk of bladder cancer

6. Chemicals tryptophan
By products of tryptophan such as 3-hydroxy-2-amino-acetophenone and 3-Hydroxyindazole
can promote the risk of bladder cancer due to reaction of β-glucuronidases.

7. Diet
Diet high in saturated fat increases the risk of bladder cancer.

8. Family history
Bladder cancer risk increase if a member of the direct family have bladder cancer.

9. Infection
Prolonged infection or frequent infection increase the risk of bladder cancer.

10. Medication
Certain types of medication can promote the forming of bladder cancer.


Causes of Bladder cancer in TCM
The traditional Chinese medicine defined bladder cancer is a health condition caused by
A. Heart Fire Shifting Downwards to the small intestine
Heart Fire is an excess problem, due to elevating yang or yang rise is out of control. Since heart is associated with the fire, excessive yang leading to fire and heat.

If heart fire with extra heat move downward to the small intestine, it affects the bladder in functioning of urinary secretion, causing blood in urine.

In other words, according to the article by TCM Shen Nong Shi,  bloody urine often indicates that the bladder meridian is over-heated, that can be a result of different internal disharmonies. Mental stress, improper diet or chronic health conditions bring about fire or heat pathogensby different organs, the pathogens irritate the urinary tract through the bladder meridian, and cause bleeding(2).

If left untreated, it can cause inflammation and bleeding, leading to bladder cancer.

1. Symptoms include(4)
1.a. Heart palpitations
1.b. Thirst
1.c. Feeling of heat
1.d. Urination with blood
1.e. Hot, dark urine
1.f. Bitter taste in the mouth
1.g. Frequent urination
1.h. Urgent need to urinate


2. Treatment with Chinese Herbs
2.1. Shui Niu Jiao (Bubalus bubalis)(3)
Shui Niu Jiao is also known as water buffalo horn. The salty, cold herb has been used in TCM as sedative, anti-inflammatory, anti-virus medicine and to shorten bleeding time, enhance quality of capillaries as it clears heat, relieve fire, cool blood, stop nosebleed, vomiting blood by enhancing the function of heart, liver, spleen, stomach channels.

2.2.  Lian Qiao (Fructus Forsythiae Suspensae)(5)
Lian Qiao is also known as forsythia fruit. The bitter, cool, and slightly acrid herb has been used in TCM as anti inflammatory medicine and to stop vomiting, promote blood circulation and urination as it helps to clears heat and toxin and expels externally wind heat by enhancing the function of heart, liver gall bladder channels.

2.3. Dan Zhu Ye (Herba Loaphatheri Gracilis)(7)
Dan Zhu ye is also known as bamboo leaves. The sweet, cold and bitter herb has been used in TCM to treat mouth sores and inflamed gums caused by heat, promotes urination and treat insomnia as it helps to clear damp heat, heart fire and stomach heat by enhancing the functions of heart, small intestine, stomach channels.

2.4. Lian Zi Xin (Lotus Plumule)(6)
Lian Zi Xin also known as Lotus Flower. The bitter and cold herb has been used in TCM as an astringent and to treat insomnia, irritability, stop bleeding and vomiting blood as it promotes the draining of heart fire and bind essence by enhancing the functions of heart and pericardium channels.



B. Damp heat moves downward to the bladder
It is caused by kidney inability to move fluid upward, resulting in fluid accumulated in the abdomen. Prolonged period of fluid accumulation promotes arise of heat, affecting the urinary secretion of the bladder, resulting of bleeding and damage the functioning of the bladder, leading to bladder cancer(8).

1. Symptoms include(8)
1.a. Frequent urination
1.b. Urgent need to urinate
1.c. Urinary pain, back pain, edema of lower limbs
1.d. Thirsty,
1.e. Difficult to go to sleep at night
1.f. Red tongue with yellow and greasy fur
1.g. Slippery and taut pulse

2. Treatment with Chinese Herbs
The function of the herbs are for diuresis, to eliminate dampness, clear heat, cool blood and stop bleeding.
2.1. Che Qian Zi (Semen Plantaginis)(9)
Che Qian Zi is also known as Plantain seed. The sweet and cold herb has been used in TCM as an antibiotic and to promote urination and to excret mucus of the bronchial tubes as it helps to clear Damp heat in the lower burner channel and damp heat cause of painful urinary, diarrhea , red eyes and sexual dysfunction by enhancing the functions of bladder, kidney, liver, lung channels.

2.2. Bian Xu (Herba Polygoni Avicularis)(10)
Bian Xu is also known as common knotgrass. The slight cold and bitter herb has been used in TCM to treat urinary infection, get rid of skin parasites and fuild and worms and stop itching as it drains damp heat in bladder, calms pain on urination by enhancing the function of bladder channel.

2.3.  Bo Ye (Cacumen Biotae Orientalis)(11)
Bo Ye or Ce Bai Ye is also known as biota leaves. The bitter, tart and slightly cold herb has been used in TCM to stops bleeding, harmonize blood, inhibit cough, anti-bacteria and anti-inflammation as it purifies and lowers the lung-Qi , clears heat and blood heat, eliminates phlegm by enhancing the function of heart, liver, large intestine and lung channels.

2.4. Yi Yi Ren (Semen coicis)(12)
Yi Yi Ren is also known as Coix Seed. The sweet, bland, slightly cool herb has been used in TCM to improve digestion, enhance the lung function, get rid of bacterial or fungal infection and treat neualgia, difficulty in urination, lung abscess as it drains water, strengthens the Spleen; eliminates obstruction and clears Heat by promoting the functions of spleen, stomach, lung channels.

2.5 Pu Gong Ying ( Herba Taraxaci Mongolici cum Radice)(13)
Pu Gong Ying also best known as Dandelion. The bitter, cold and sweet herb has been used in TCM as a diuretic and to promote bile secretion, protect the liver, inhibit staphylococcus aureus, Streptococcus pneumoniae, Pseudomonas aeruginosa as it clears heat, expels toxins, drains Dampness by enhencing the function of liver and stomach channels.


C. Kidney and liver yin deficiency(14)
Kidney and liver yin deficiency cause of yang elevation, toxin accumulation and blood stagnation in the bladder that can lead to the forming of tumor.
This type is mostly seen at the advanced age, or chemotherapy or radiotherapy cause of heat reaction or complicated by infection.
1. Symptoms include(14)
1.a. Frequent urination, sometimes
1.b. Blood in the urine
1. c. Abdominal distension and pain
1.d. Back pain
1.e. Dry mouth but don't like to drink
1.f. Constipation
1.g. Light red tongue with little fur, or uncoated and smooth tongue
1. h. Thready pulse


2. Treatment with Chinese Herbs
The main functions of herb are to nourish yin, invigorate kidney, clear stagnation and detoxify.
2.1.  Mai Dong (Tuber Ophiopogonis Japonici)(15)
Mai Dong is also known as Ophiopogon Root. The sweet, slight bitter and cold herb has been used in TCM to improve contraction of heart muscles, recovery of cells of the pancreas and immune system, protect heart muscle, lower blood sugar and anti-arrhythmia as it
moistens the lungs, nourishes Lung-Yin, benefits the stomach and the heart, promotes generation of body fluids, clear heat by promoting the functions of heart, lung, stomach channels.

2.2.  Shi Hu (Herba Dendrobii)(16)
Shi Hu is also known as Dendrobium. The sweet, bland, slightly cold herb has been used in TCM to treat weakness after febrile diseases, thirsty, thromboangitis obliterans, chronic throat infection, blurry vision and weak lower back as it nourishes the stomach and yin, clear heat, promotes generation of body fluids by enhancing the lung and stomach channels.

2.3. Nu Zhen Zi (Fructus Ligustri Lucidi)(17)
Nu Zhen Zi is also known as Glossy Privet Fruit. The bitter, sweet and neutral herb has been used to promote immune system and circulatory system, anti inflammatory, anti cancer properties, lower blood sugar and protect the liver as it tonifies the liver and kidneys, clears heat and improves vision by soothing the functions of liver and kidney channels.

2.4. Long Kui (Herb Solani nigri)(18)
Long Kui is also known as wonderberry. The bitter, cold, slightly sweet and toxic herb has been used in TCM as diuretic and antipyretic and to treat acute kidney inflammation, chronic bronchitis, throat cancer, larynx Cancer, uterus cancer as it clears heat, eliminates toxin, improve urination by enhancing the function of liver, kidney and stomach channels.

2.5. Fu Ling (Sclerotium Poriae Cocos)(19)
Fu Ling is also known as Indian Bread. The sweet, bland, neutral herb has been used in TCM as a diuretics and to treat insomnia or forgetfulness, loss of appetite and inflammation of the uterus and chronic sinusitis as it eliminates water, strengthens the spleen, calms the mind, clear damp-heat by enhancing the function of heart, spleen, lung, kidney channels.


Treated Bladder Cancer with Foods in TCM
In traditional Chinese medicine, the herb, Ling Zhi (Reishi mushroom) is viewed to process substances with antibacteria, antivirus and antitumor properties.

 In general public, most mushrooms contain the same values but differing in volume.
1. Shiitake or Chinese black mushroom(20)
Shiitake contains protein, glutamic acid, low cholesterol, β-glucosidase and 18 amino acids. Some researchers found that shiitake mushroom may stimulate the immune system, possess antibacterial properties, reduce platelet aggregation, and possess antiviral properties, possibly through antiviral agents known as proteinase inhibitors.

Lentinan in Shiitake enhances the immune function and prevents our body against cancer. The substance of interferon inducer may be used to treat cancer(21).

2. Agaricus campestris
Agaricus campestris contains high amount of B vitamin and inorganic salts. In rat study, researchers found that Agaricus campestris inhibits the progression of cancer cells(22).

3. Hericium erinaceus

One of the favorite food in many Chinese expensive recipe, Hericium erinaceus may inhibit the growth of tumor. In China, Some of the pharmaceutical drug company have made them in form of Mushroom slices for use in preventing and treating stomach and Esophageal cancer(23).

4. Tremella(24)
Tremella contains high amount of fiber, protein, calcium, polysaccharides, etc. Researchers found that tremella enhances the immune system scavenging, T cells and B lymphocytes functions, thus preventing the progression of cancer cells.

5. Flammulina(25)
Beside it has been used in TCM to treat liver inflammation, ulcer and lower blood cholesterol, in 1982 study, researchers in Japan found that certain substances in flammulina help to protect our body against cells DNA mutation cause of cancer.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Kyle J. Norton, Bladder Cancer
(2) Blood in Urine and Chinese Medicine by Shen-Nong-Shi
(3)Shui Niu Jiao (Bubalus bubalis) by American Dragon

(4) Heart Fire, The kind of Heat in your Heart you don't want! by Acupuncture Points
(5) Chinese Herbs – Lian Qiao (Fructus Forsythiae Suspensae) 
(6) Chinese Herbs -Lian Xin or Lian Zi Xin (Plumula Nelumbinis Nuciferae)
(7) Dan Zhu Ye (Lophatherum Stem and Leaves)
(8) Damp Heat Moving Down Ward to Bladder
(9) Che Qian Zi (Plantago Seed, Plantain Seed)
(10) Bian Xu (Herba Polygoni Avicularis)
(11) Chinese Herbs – Bo Ye (Cacumen Biotae Orientalis)
(12) Chinese Herbs - Yi Yi Ren (Semen Coicis Lachryma-Jobi)
(13) Pu Gong Ying (Dandelion)
(14) Liver and Kidney Yin Deficiency
(15) Chinese Herbs – Mai Dong or Mai Men Dong (Tuber Ophiopogonis Japonici)
(16) Chinese Herbs – Shi Hu (Herba Dendrobii)
(17) Chinese Herbs – Nu Zhen Zi (Fructus Ligustri Lucidi)
(18) Chinese Herbs– Long Kui (Herb Solani nigri)
(19) Chinese Herbs – Fu Ling (Sclerotium Poriae Cocos)
(20_ Recent developments in mushrooms as anti-cancer therapeutics: a review by Seema Patel1 and Arun Goyal(PMC)
(21) NCI Dictionary of Cancer Terms
(22) Medicinal Mushroom Extracts Possess Differential Antioxidant Activity and Cytotoxicity to Cancer Cells by Elbatrawy EN1, Ghonimy EA2, Alassar MM3, Wu FS(PubMed).
(23) Anticancer potential of Hericium erinaceus extracts against human gastrointestinal cancers by Li G1, Yu K1, Li F1, Xu K1, Li J1, He S2, Cao S3, Tan G(PubMed)
(24) Comparison of Immunomodulatory and Anticancer Activities in Different Strains of Tremella fuciformis Berk by Han CK1, Chiang HC2, Lin CY3, Tang CH4, Lee H5,6,7,8, Huang DD3, Zeng YR3, Chuang TN3, Huang YL(PubMed)
(25) Treatment of cancer with mushroom products by Monro JA(PubMed).

*Green Tea and It's Bioactive Epigallocatechin 3-gallate (EGCG) That Target Arthritis With No Side Effects, Scientists Suggested

By Kyle J. Norton, Master of Nutrition

Green tea may have a therapeutic and positive effect in reduced risk and progression and treatment of arthritis, some scientists suggested.

Arthritis is a class of chronic condition characterized by painful inflammation and stiffness of the joints, usually seen in adults over the age of 65.

Others symptoms of arthritis also include redness, warmth, swelling, and decreased motion of the affected joints.

Rheumatoid Arthritis in severe cases can also effect the bone density, cause skin nodules, eye,...... and lung inflammation and scarring.

As of today. there are no cure of the disease. Depending to types of arthritis, analgesics and Nonsteroidal anti-inflammatory drugs (NSAIDs) are common use for treatment of pain and inflammation. However, in rheumatoid arthritis medicine, disease-modifying antirheumatic drugs (DMARDs) and Corticosteroids are the first line medicine use to suppress over active immune system in attacking its own joints.

Most arthritis are caused by wear and tear of the joints. However, long term infection or injury without proper treatment can elevate the natural breakdown of cartilage tissue of the joints.

According to CDC(5), in the years of 2013–2015, approximately 22.7% or 54.4 million are affected by the disease, with significantly higher age-adjusted prevalence in women (23.5%) than in men (18.1%).

Although, arthritis prevalence increases with age, physical inactivity is associated to higher risk of arthritis development.

Sadly, the CDC continued, "With the aging of the US population, the prevalence of doctor-diagnosed arthritis is expected to increase in the coming decades. By the year 2040, an estimated 78.4 million".

Green tea, is a precious drink processed numbers of health benefit known to almost everyone in Asia and Western world.

According to the College of Pharmacy, green tea epigallocatechin 3-gallate (EGCG) in preclinical studies displayed a significant effect in treatment of arthritic disease.

In vitro, application of green tea extract EGCG demonstrated activities in cartilage-preserving and chondroprotective action through reduced expression of proinflammatory IL-1β, TNFα, and IL-6
and modulated extracellular matrix (ECM) turnover induced changes of the biomechanical environment of chondrocytes and accelerate the degradation of cartilage as well driving the progression of the disease in the presence of inflammation.

Normal extracellular matrix (ECM) is a composed collagen type II with function to provide tensile support for the tissue.

Further analysis in expression of proinflamatory factors researchers found that the over expression of proinflammatory cytokines IL-1 and IL-6 were associated correlatively in knee joints in arthritis and inhibition of IL-1 snd IL-6 by green tea EGCG IL-1 showed to reduce joint damage.

Some researchers also suggested that Interleukin 1 (IL-1) is a crucial mediator of the inflammatory response, playing an important part in the body's natural responses and the development of pathological conditions leading to chronic inflammation.

In expression of tumor necrosis factor (TNF), tumor necrosis factor alpha(TNFα, cachexin, or cachectin), application of green tea inhibited the levels of TNFα in induction of synovial fibroblast cytotoxicity.

Interestingly, in the study to evaluate the possible effects of the administration of green tea extract on the oxidative state of the liver and brain of adjuvant-induced arthritic rats, researchers indicated that green tea daily doses of 250 mg kg(-1) (59.8 mg catechins per kg) for 23 days displays a strong effect in decreased symptoms of arthritis by ameliorated diminutions in protein and lipid damage in liver, brain and plasma, through antioxidant effect in reduced levels of ROS in stimulated free radical chain reaction to initiate production of pro inflammatory cytokines in precipitated chronic diseases.

Rats treated with green tea EGCG also showed a significant improvement in restored natural antioxidant glutathione (GSH) and protein thiol levels produced by the body, by exhibiting the activities of the antioxidant enzymes.

Moreover, green tea injection also normalized the activity of glucose 6-phosphate dehydrogenase, which is increased in the liver of arthritic patients and considered as a risk factor for the development of arthritis. Increased activity glucose 6-phosphate dehydrogenase was associated to reactive oxygen species (ROS) generated in oxidative metabolism in inflicted damage on all classes of macromolecules.

Additional differentiation of green tea EGCG immunomodulatory effects and mechanisms on experimental arthritis induced by collagen-induced arthritis (CIA) mice in compared to control received phosphate buffered saline (PBS), researchers found that application of green tea EGCG at dose of 10 mg/kg demonstrated a strong effect in ameliorated clinical symptoms and reduced histological scores, through modulated the immune activity by induced over expression of the Nrf-2 antioxidant pathway, a major mechanism in the cellular defense against oxidative or electrophilic stress through detoxication and elimination.

EGCG also ameliorated experimental arthritis in mice by eliciting indoleamine-2,3-dioxygenase (IDO) through inhibition of pro-inflammatory cytokine interferon-gamma, astrocytes and microglia in facilitated production of dendritic cells (DCs) that activate the immune system to attack the dendritic cell located on surface on the joint tissue.

Application of the EGCG also increased frequencies of T regs with a dominant role in suppression of autoimmune pathology.

Some researchers suggested that increased Treg number and/or function in model systems may have a significant effect in both prevented and reversed arthritis disease.

Taken together, green tea with abundant bioactive polyphenol epigallocatechin 3-gallate (EGCG) may be considered as a functional food for alleviated symptoms, reduced risk, and progression and treatment of arthritis.

However, further data collection on large example size and multi centers studies performed with human consumption of the green tea and its bioactive polyphenol epigallocatechin 3-gallate (EGCG), during the course of the disease will be necessary to complete the picture of their anti arthritis possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Green tea extract improves the oxidative state of the liver and brain in rats with adjuvant-induced arthritis by de Almeida Gonçalves G1, de Sá-Nakanishi AB, Wendt MM, Comar JF, Bersani Amado CA, Bracht A, Peralta RM.(PubMed)
(2) Green Tea Epigallocatechin-3-Gallate Suppresses Autoimmune Arthritis Through Indoleamine-2,3-Dioxygenase Expressing Dendritic Cells and the Nuclear Factor, Erythroid 2-Like 2 Antioxidant Pathway by Min SY1, Yan M1, Kim SB2, Ravikumar S1,3, Kwon SR1,4, Vanarsa K1,3, Kim HY4, Davis LS#1, Mohan C(PubMed)
(3) Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise by Ahmed S1.(PubMed)
(4) Is IL-1 a good therapeutic target in the treatment of arthritis? by Burger D1, Dayer JM, Palmer G, Gabay C.(PubMed)
(5) National Statistics by CDC