Some Serious Complications of Dementia, Even Caregivers May Not Aware Of

About 5-8% of all people over the age of 65 have some forms of dementia, and these numbers double every five years above that age.

Dementia is the loss of mental ability that is severe enough to interfere with people's everyday life.

 And Alzheimer's disease is the most common type of dementia in aging people.

According to the The University of Manchester, Unhealthy diet with high fat consumption are associated in increased risk on neuroinflammation causing both the neuropathology and memory impairments in animal model(15)..

In the study conducted by Ichinomiya City Hospital, Ichinomiya, Japan, Dr. Ukai K, and Mizuno Y. said, " Physical complications that occurred in our ward in the 12 months from April 2007 to March 2008 were recorded. Our ward has 50 beds and, over the 12 months, the average occupation rate was approximately 90%. We subdivided physical complications into two categories: (i) serious emergencies occurring in the ward with a possible high risk of mortality within a few days (e.g. pneumonia and upper airway obstruction); and (ii) life-threatening complications arising in the ward that required diagnosis and treatment by specialists from other medical departments (e.g. bone fracture andcancer)"(10).

The serious complications that caregiver may not be award of

1. Pneumonia
In the study of Beth Israel Deaconess Medical Center, Boston, Massachusetts, Dr. Givens JL showed that Pneumonia is common among patients with advanced dementia, especially toward the end of life.

Whether antimicrobial treatment improves survival or comfort is not well understood.

The objective of this study was to examine the effect of antimicrobial treatment for suspected pneumonia on survival and comfort in patients with advanced dementia.(11)

2. Obstructive Sleep Apnea Syndrome (OSAS)
The prevalence of OSAS increases with aging, occurring in up to 25% of older adults and up to 48% in patients with Alzheimer's disease. OSAS causes hypoxia, fragmented sleep, daytime sleepiness, cognitive dysfunction, functional decline, and brain damage resulting from reduced cerebral blood flow, ischemic brain lesions, microvascular reactivity, white matter lesions, and grey matter loss(12)

3. Bone fracture
In the study to investigate the relationship between bone mass and dementia in elderly hip fracture patients from areas with different aluminium concentrations in water supplies to determine researchers found that high concentration of aluminium in the drinking water and the negative calcium balance are age-related osteoporosis together predispose to senile dementia.(13)

4. Urinary incontinence
Urinary incontinence may require insertion of a urinary catheter, which is known to increase the risk of UTIs.

Urinary incontinence is a common problem in dementia. Almost invariably, the person with dementia will develop incontinence as the disease progresses.

However, the primary reasons for incontinence are often not because of any significant pathology in the urinary system. Rather, it is due to factors outside the urinary system.(14)

5. Venous thromboembolism
In the study to assess 37988 patients of whom 1316 (3.5%) had dementia, venous thromboembolism (VTE) patients with dementia had a high incidence of fatal pulmonary embolism (PE) and fatal bleeding.

In those initially presenting with PE, the risk of dying of PE far outweighed that of fatal bleeding.

And,  in patients presenting with DVT alone, the risk of fatal PE was lower than that of fatal bleeding.(15).



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(10) http://www.ncbi.nlm.nih.gov/pubmed/20377817
(11) http://www.ncbi.nlm.nih.gov/pubmed/20625013
(12) http://www.ncbi.nlm.nih.gov/pubmed/20739254
(13) http://www.ncbi.nlm.nih.gov/pubmed/3239502
(14) http://www.ncbi.nlm.nih.gov/pubmed/16642241
(15) http://www.ncbi.nlm.nih.gov/pubmed/22374336
(16) https://www.ncbi.nlm.nih.gov/pubmed/24630364

Coffee Gobbles Up Arterial Plaque, in Reduced Mortality Risk of Myocardial Infarction (Heart Attack), Scientists Say

By Kyle J. Norton

Habitual coffee consumed by myocardial infarction patients showed a significant reduced risk and rate of mortality, some scientists suggested.

Myocardial infarction is another term of heart attack occurred when blood flow suddenly decreases or stops to a part of the heart, that cause substantial damage to the heart muscle.

The causes of heart attack are associated to the building up plaque in the arteries, affecting the volumes of blood flood in transport nutrients and fluids to the body organs and tissue due to narrowing of the blood vessels.

Cholesterol narrowing the arteries is one common cause of coronary artery disease, a major cause of heart attack.

According to the National Heart, Lung, and Blood Institute (NHLBI), plaque is made up of fat, cholesterol, calcium, and other substances found in the blood.

People in the early stage of heart attack may experience symptoms of chest pain or discomfort which may affect upper body, including pain of the shoulder, arm, back, neck, or jaw.

Researchers at the Mayo clinic suggested, "Limiting how much saturated and trans fats you eat is an important step to reduce your blood cholesterol and lower your risk of coronary artery disease" and "A high blood cholesterol level can lead to a buildup of plaques in your arteries, called atherosclerosis, which can increase your risk of heart attack and stroke".

In the differentiation of the effect of fruit and vegetable intake and risk for coronary heart disease, Dr. Joshipura KJ at Harvard School of Public Health indicated
* Highest quintile of vegatables and fruits intake is associated to reduced risk of coronary heart disease with the relative odd ratio of .80 in compared to lowest quintile of intake.

* The risk of coronary heart disease is reduced by 4% for each 1-serving/d increase of fruits or vegetables. The odd ratio is decrease further to those who eat green leafy vegetables, regularly.

Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

In a study of 4365 Dutch patients from the Alpha Omega Cohort, aged 60-80 y (21% female) and experienced an MI <10 y before study enrollment, using baseline (2002-2006), to evaluate the dietary data including coffee consumption over the past month collected and 203-item validated food-frequency questionnaire, after examine the returned questionnaire from participants, researchers showed that
* Most of patients(96%) were coffee drinkers
*  Intake of coffee >4 cups/d, regularly and daily expressed a inverse association to risk of mortality in compared to 0-2 cups/d.
* Motility risk after myocardial infarction (MI) was decreased for every cup of additional coffee intake

Interesting, researchers also found out that there were no risk difference between caffeine and decaffeinated coffee.


These findings suggested that the efficacy of reduced risk of mortality of MI patients may be associated to chemical constituents in coffee, other than caffeine.

Additionally, in the review of literature in the data base of MEDLINE and Embase published between 1946 and 2015, 2 eligible studies involved-AMI mortality risk against coffee consumption with a total of 3271 patients and 604 died, in patients classified as light coffee drinkers (1-2 cups/day) versus noncoffee drinkers, heavy coffee drinkers (a>2 cups/day) versus noncoffee drinkers and heavy coffee drinkers versus light coffee drinkers, scientists filed the following results
* All groups showed a significant reduction in risk ratio in compared to non drinkers.

* The hazard risk ratio was 0.79 in light coffee drinkers versus noncoffee drinkers.

* The risk ratio of 0.54 was found in heavy coffee drinkers versus noncoffee drinkers and

* Heavy coffee drinkers versus light coffee drinkers were associated with a risk ratio of 0.69


Although there was no linear association of amount of coffee intake in risk of MI and MI morality, coffee intake expressed a strong effect against risk of MI and MI death in patients after heart attack.

These results of coffee efficacy may be associated to coffee hypercholesterolemic activity in prevention of cholesterol building up for the development of coronary artery disease(5).

Most important, eventhough habitual coffee consumption exerted a enormous effect in reduced risk
coronary heart disease, congestive heart failure, arrhythmias, and stroke as well as decreasing risk of mortality, but most of the data on coffee's health effects are based on observational examine with very few randomized, controlled studies, and association does not prove causation.

There fore, further data collection on studies performed with human consumption over a long term in compared coffee and non coffee intake ( risk of heart attack)and during the course of the disease(risk of mortality) will be necessary to complete the picture of  possibilities of coffee efficacy.

Additionally, while addressing the possible advantages of regular coffee consumption, researchers must also take into account of potential, risk such as anxiety, insomnia, tremulousness, and palpitations.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Coffee consumption after myocardial infarction and risk of cardiovascular mortality: a prospective analysis in the Alpha Omega Cohort by van Dongen LH1, Mölenberg FJ1, Soedamah-Muthu SS1, Kromhout D1,2, Geleijnse JM3.(PubMed)
(2) Coffee reduces the risk of death after acute myocardial infarction: a meta-analysis by Brown OI1, Allgar V, Wong KY.(PubMed)
(3) Effects of habitual coffee consumption on cardiometabolic disease, cardiovascular health, and all-cause mortality by O'Keefe JH1, Bhatti SK, Patil HR, DiNicolantonio JJ, Lucan SC, Lavie CJ.(PubMed)
(4) The effect of fruit and vegetable intake on risk for coronary heart disease by Joshipura KJ1, Hu FB, Manson JE, Stampfer MJ, Rimm EB, Speizer FE, Colditz G, Ascherio A, Rosner B, Spiegelman D, Willett WC(PubMed)
(5) Coffee polyphenols exert hypocholesterolemic effects in zebrafish fed a high-cholesterol diet by Meguro S, Hasumura T, Hase T.(PubMed)

^^^^***A Food With Anti Inflammatory Diseases and Conditions Potency, Scientists Say

Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)


Eggplant may be used as a therapeutic and positive anti inflammatory functional food without alternating the immune activity in inflammatory diseases and conditions, some scientists opinionated.

Eggplant with deeply purple colcor, is a species of S. melongena, belongs to the family Solanaceae cultivated in southern and eastern Asia since prehistory, and native to India.

Inflammation is a natural expression by immune system in induction of while blood cells for protection our body against infection caused by foreign invasion.

However, Over stimulation of inflammatory cytokines to fight the infection may have strong negatively impact on the body tissue and organs, such as forming of scars, death of the healthy cells in the infectious site.

Prolong period of inflammation may lead permanently tissue damage and alternation of DNA of healthy cells.

Some researchers suggested that chronic inflammation can eventually lead to development of numbers of diseases and conditions, including some cancers, diabetes and rheumatoid arthritis.

For example, risk of colon cancer is increased substantially to people with chronic inflammatory ulcerative colitis and Crohn disease in compared to health adults

Dr. Leonard BE at the joint study involved diseases association to long term inflammation, lead by the National University of Ireland, said, "Physical ill-health is a common feature of depression. Cardiovascular disease, type 2 diabetes and cancer are, for example, common occurrences and lead to increased morbidity and mortality" and "( that the causes of inflammatory diseases may be) attributable to an unhealthy life style or due to genetic or other causes that are exacerbated by stress and adverse environmental factors"(4).

According to Canadian statistic, approximately 233,000 Canadians are living with IBD in 2012 (129,000 individuals with CD and 104,000 with UC), corresponding to a prevalence of 0.67%. And approximately 10,200 incident cases occur annually. IBD can be diagnosed at any age, with typical onset occurring in the second or third decade of life(5).


Researchers today still don't know why some people are susceptible to the disease prevalence while others don't.

Most common risk factors of inflammatory diseases include unhealthy diet, hormones expression, use of immunosuppressive and infectious drugs, obesity, prolong exposure to sunlight and radiation, tobacco, old age, alcohol abuse, .... and cancer-causing substances.

In the differentiation of water extract of Solanum melongena L. (Solanaceae) effect in induction of antioxidant, analgesic, hypolipidemic and antiallergic activity in mice induced by injection of trypsin or trans-cinnamoyl-LIGRLO-NH(2) (tc-NH(2)) into the hindpaw, scientists found that oral administration of the extract at doses of 5, 10, and 100 mg/kg display strong effects in inhibition of both paw edema and vascular permeability.

Further analysis also showed that the highest dose injection of 10 mg/kg expressed a greatest activity in compared to the others in significantly inhibited PAR2 agonist-induced myeloperoxidase (MPO) activity in stimulated immune function activated pro inflammatory cytokines and tumor necrosis factor (TNF)-alpha expression to precipitate inflammation in response to the acute phase of infection.


Proteinase-activated receptor-2 (PAR2), are a family of four G-protein-coupled receptors found in the inflammatory cells and epithelial tissues that process a function in participated in the development of inflammatory diseases.


In these cases, Proteinase-activated receptor-2 (PAR2) induced inflammation through activated pro inflammatory cytokines, such as tumor necrosis factor (TNF)-alpha involved systemic inflammation in the acute phase reaction.

After taking into account of other con-founders, Dr. Umamageswari MS suggested that water extract of the S. melongena (SMWE) inhibits PAR2 agonist-induced mouse paw edema, through its anti inflammatory expression.

According to the investigated the inflammatory activities of aqueous extract of leaves of Solanum melongena Linn in arrageenan induced paw edema, in compared to standard medicne aspirin, oral application of Solanum melongena L. in different doses of 100mg/kg, 200mg/kg, 400mg/kg at 1(st) h, 3(rd) h, and 5(th) after injection revealed a significant effects in reduced inflammation linearly induced by carrageenan toxicity in dose dependent manner.

Additional differentiation, also suggested that the doses of 200mg/kg and 400 mg/kg of aqueous extract of S. melongena L showed the percentage of inhibition of 42.62% which is less than the standard drug aspirin which showed 64.5% inhibition.


In free radical induced chronic inflammation, the investigation of 4 our new lignanamides, melongenamides A-D (1-4), together with six known ones (5-10) isolated from the roots of Solanum melongena L. also demonstrated a significant activity in inhibitions of inflammatory effect caused by free radical species nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages through their antioxidant effect.

Interestingly, the study also found out that not all compound extracted from the roots expressed the same levels of antioxidant properties in reduced inflammatory induced by ROS.

In compared to other compounds, compound melongenamide 1  exerted antioxidant effect without inhibited free radical nitric oxide production.


The findings suggested that eggplant may be used as function food in reduced risk of inflammation in acute infection and as a adjunct therapy in combination with standard treatment of chronic inflammatory diseases.

However, further data collection on studies performed with human consumption during the course of the diseases and conditions are necessary to complete the picture of eggplant anti inflammatory  possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) The aqueous extract of Solanum melongena inhibits PAR2 agonist-induced inflammation by Han SW1, Tae J, Kim JA, Kim DK, Seo GS, Yun KJ, Choi SC, Kim TH, Nah YH, Lee YM.(PubMed)
(2) Evaluation of anti-inflammatory activity of aqueous extract of leaves of solanum melongena linn. In experimental animals by Umamageswari MS1, Maniyar YA2.(PubMed)
(3) Anti-inflammatory lignanamides from the roots of Solanum melongena L by Sun J1, Gu YF1, Su XQ1, Li MM1, Huo HX1, Zhang J1, Zeng KW2, Zhang Q3, Zhao YF3, Li J4, Tu PF5.(PubMed)
(4) Inflammation as the cause of the metabolic syndrome in depression by Leonard BE(PubMed)
(5) Inflammatory bowel disease: A Canadian burden of illness review by Angela Rocchi, MSc,1 Eric I Benchimol, MD PhD,2 Charles N Bernstein, MD,3 Alain Bitton, MD,4Brian Feagan, MD,5 Remo Panaccione, MD,6 Kevin W Glasgow, MD,7 Aida Fernandes, MBA,7 andSubrata Ghosh, MD(PubMed)

Appendicitis:The Causes and Risk Factors

By Kyle J. Norton

Appendicitis is a condition characterized by inflammation of appendix.

It is classified as an emergency, in many required the removal of the appendix.

If bursted, or perforated, spilling infectious materials into the abdominal cavity, can be life threatening.

A. Causes
The cause of appendicitis is the result of blockage by stool, a foreign body, or cancer of that can lead to infection.
1, Bacterial, viral and parasitic infiection
According to the study by the, the pathologic spectrum of the inflamed appendix encompasses a wide range of infectious entities, some with specific histologic findings, and others with nonspecific findings that may require an extensive diagnostic evaluation.

 The appendix is exclusively involved in some of these disorders, and in others may be involved through extension from other areas of the gastrointestinal tract(4).

Other in the study to investigate the role of parasitic infestation in the etiology of acute pediatric appendicitis, indicated that parasites are present in 5.5% (88 patients), and of those 88 parasitic infestations, 45 (51.1%) are Enterobaisis, 8 (9.1%) are Schistosomiasis, 23 (26.1%) are Ascariasis, 7 (8%) Trichuriasis, and 5 (5.7%) are Teania Saginata.

The percentage of patients with suppurative, gangrenous or perforated appendicitis was similar in both groups with no statistical significance, irrespective of the presence or absence of parasitic infestation(5).

2. Foreign objects
Appendicitis and its complications remain a common problem affecting patients of all age groups.

 Appendicitis due to foreign bodies is rare and carries an estimated frequency of 0.0005%.

But according to the Department of Surgery, Heilig Hart Tienen, there is a case of a 44-year-old man with appendicitis induced by an appendicolith containing eight steel shotgun pellets.

The man was a recreational hunter and for the past 20 years he consumed wild game on a regular basis(6).

B. Risk factors
1. Age 10 × 103/mm
In the study to evaluate the impact of timing of appendectomy and other potential risk factors on progression of acute appendicitis, by searching the relevant databases of a tertiary medical center identified 1,604 patients with verified acute appendicitis who underwent appendectomy in 2004-2007with demographic and clinical data and time from symptom onset to emergency room admission (“patient interval”) and from emergency room admission to surgery (“hospital interval”) and their combination were analyzed by pathological grade, researcher found  that on multivariate analyses, independent risk factors for appendiceal perforation were age 50 years, white cell count >10 × 103/mm(3), body temperature >37.8 °C, hospital interval >24 h, patient interval >48 h , and combined interval >48 h.

2. Gender difference, among young
According to study appendicitis is common among young, healthy populations; appendectomy is one of the most common surgical procedures performed in the United States.

Among active and reserve component members, there were 31,610 cases of appendicitis and 30,183 appendectomies during 2002 to 2011.

The overall incidence rate of appendicitis in the active component was 18.4 per 10,000 person-years (p-yrs).

Active component males reported greater rates of perforated appendicitis (2.6 per 10,000 p-yrs).

Active component females had higher rates of incidental appendectomies (2.6 per 10,000 p-yrs)(8).

3. Race, increased over time and is higher in the summer months
Appendicitis is most common in whites and Hispanics and less common in African Americans and Asians.

And incidence has increased over time and is higher in the summer months, according to the study by the University of California San Diego(9).

4. Prior antibiotic administration
Prior treatment with antibiotics was an independent risk factor for therapeutic delay in pediatric AA, according to the study by the National Center for Child Health and Development, Tokyo(10).

5. Factors associated with an increased likelihood of appendicitis included decreased bowel sounds; rebound tenderness; and presence of psoas, obturator, or Rovsing’s signs(11).

6. In patients with end-stage renal disease
The independent risk factors were atrial fibrillation (hazard ratio [HR], 2.08), severe liver disease (HR, 1.74), diabetes mellitus (HR, 1.58), and hemodialysis (HR, 1.74), according to the study by the Taipei Medical University(12).

7. Severity of inflammation
CRP concentration may be a potent objective predictor of pathological severity in appendicitis. Combination with the other diagnostic modalities may improve the diagnostic accuracy in predicting the severity of appendicitis(13).

8. Appendicolith
Presence of an appendicolith was associated with a 72% rate of recurrent appendicitis compared with a recurrence rate of 26% in those with no appendicolith.

9. Other risk factors
The principal factors contributing to perforation of appendix are: age of children, delays of surgical intervention, family anamnesis, social group and late recognition of symptoms of appendicitis(14).


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Kyle J. Norton(Scholar, Master of Nutrition), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(5) http://www.ncbi.nlm.nih.gov/pubmed/23599875
(6) http://www.ncbi.nlm.nih.gov/pubmed/23397832
(7) http://www.ncbi.nlm.nih.gov/pubmed/23374326
(8) http://www.ncbi.nlm.nih.gov/pubmed/23311330
(9) http://www.ncbi.nlm.nih.gov/pubmed/22948195
(10) http://www.ncbi.nlm.nih.gov/pubmed/22858754
(11) http://www.ncbi.nlm.nih.gov/pubmed/22849662
(12) http://www.ncbi.nlm.nih.gov/pubmed/22777056
(13) http://www.ncbi.nlm.nih.gov/pubmed/22234068
(14) http://www.ncbi.nlm.nih.gov/pubmed/10965688
(15) http://www.ncbi.nlm.nih.gov/pubmed/16226993

Infectious Diseases: Scientists Successfully Found the Minerals and Mineral Compouds That Suppress Over Growth of Candida, Cited by MEDLINE

By Kyle J. Norton, Scholar, Master of Nutrition

Candida albicans are members of a large group of micro organism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.

Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).

According to joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased candida resistance toward antifungal drugs.

ROS species have duo functions that are well documented for playing an important role in our body as both beneficial and deleterious molecules in expression of cytotoxicity against abnormal cells alternation and initiation of chronic ailments by causing imbalance of the ratio among antioxidants and free radicals, respectively.

Minerals and mineral compounds, the organic substances are also essential in improved cellulars process, but the amounts required are very small.

Over expression minerals are toxicity to body's organs and tissue.

In free radical over expression initiated over growth candida, as differentiated in the vitamins article, application of addition of minerals of concentration µM500 µM exerted a significant effect in inhibited DPPH, chemical compound 2,2-diphenyl-1-picrylhydrazyl of stable free-radical molecules(a).

The Anti Over Growth of Candida minerals and mineral compounds
1. Coral Calcium
One of the richest sources of calcium not only is an important mineral in building stronger, denser bones early in life and keeping bones strong(248) and healthy later in life and preventing the risk of osterporosis(249), but also alkalize the body to eliminate the favor environment for candida overgrowth(250).


2. Magnesium Citrate
Magnesium Citrate is a magnesium salt of citric acid, a chemical agent used medicinally as a saline laxative(251). Besides it is important to maintain proper level of pH(252) for the body's organs to enhance their biochemical pathways for detoxification(253), the mineral compound also limits or reduces the over growth of candida.

Magnesium Citrate can act as a defecation in stimulating naturally bowel movement.

The mineral, magnesium plays a key role in the immune response, by acting as a co-factor for immunoglobulin synthesis(254) that significantly increase for both IgA and IgG, the antibody molecules to protect our body against bacterial and viral infections(255) and the lining of the respiratory passages, gastrointestinal and genitourinary tract(255).

3. Lithium chloride
Lithium chloride is a chemical compound with the formula LiCl. The salt is a typical ionic compound.

While maintaining the proper PH levels(257), lithium also suppresses the yeast phosphoglucomutase activity(256) and inhibits the candida albicans filamentation and hyphal outgrowth(258).

4. Sodium bicarbonate
Used as an alkaline treatment(259), sodium bicarbonate is important to balance the levels of PH by taking away the acidity environment for candida overgrowth(260)(261). 

Researchers found that 5% sodium bicarbonate on the adherence of Candida albicans to thermally activated acrylic resin proved to be a viable alternative in the reduction of Candida albicans(262).

5. Phosphonium salts
Phosphonium salts with long alkyl chains (C18) show high levels of antimicrobial activity(263).

Application of  alkyltrimethylphosphonium salts(263) inhited the bactericidal activity against S. aureus and Escherichia coli by increasing alkyl chain length(263), probably through its antimicrobial polymers(264), according to the joint study by University of New Brunswick, Southwest Petroleum University, and North China Electric Power University

6. Zinc
Zinc is an important mineral in boosting immune system activity(265)(266). 

Its nano-structure zinc(II) coordination compounds, has been used in zinc therapy to treat candida overgrowth(267) by promoting metallothionein (MT)(found in high concentration in intestinal mucosa)synthesis(268) through its anti inflammatory activity(269).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(a) Effect of minerals on free radicals induced damages in drosophila melanogaster by Neethu C. B and Shibu Vardhanan at University of Calicut(Research Gate)
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ.(PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeastspecies. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMerd)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)(247) The role of vitamin E in T-cell differentiation and the decrease of cellular immunity with aging.by Moriguchi S1.(PubMed)

(249) By the way, doctor. I recently saw a TV ad for a product called "coralcalcium," which is supposed to prevent osteoporosis and other diseases. What do you know about it by Robb-Nicholson C.(PubMed)
(250) The effect of probiotic bacteria on transepithelial calcium transport and calcium uptake in human intestinal-like Caco-2 cells by Gilman J1, Cashman KD.(PubMed)
(251) Sodium Picosulfate with Magnesium Citrate (SPMC) Plus Laxative Is a Good Alternative to Conventional Large Volume Polyethylene Glycol in Bowel Preparation: A Multicenter Randomized Single-Blinded Trial by Kim HG1, Huh KC, Koo HS, Kim SE, Kim JO, Kim TI, Kim HS, Myung SJ, Park DI, Shin JE, Yang DH, Lee SH, Lee JS, Lee CK, Chang DK, Joo YE, Cha JM, Hong SP, Kim HJ.(PubMed)
(252) Effect of potassium magnesium citrate on thiazide-induced hypokalemia and magnesium loss.
Ruml LA1, Pak CY.(PubMed)
(253) Efficacy of magnesium citrate cathartic in pediatric toxic ingestions by Sue YJ1, Woolf A, Shannon M.(PubMed)
(254) Study of possible correlation between BLOOD IMMUNOGLOBULIN G INCREASED and MAGNESIUM CITRATE(Meds fact)
(255)In vitro antiviral and antibacterial activity of commercial intravenous immunoglobulin preparations--a potential role for adjuvant intravenous immunoglobulin therapy in infectious diseases by Krause I1, Wu R, Sherer Y, Patanik M, Peter JB, Shoenfeld Y.(PubMed)
(256)In-silico identification and characterization of organic and inorganic chemical stress responding genes in yeast (Saccharomyces cerevisiae) by Barozai MY1, Bashir F2, Muzaffar S2, Afzal S2, Behlil F2, Khan M2.(PubMed)
(257) Four pathogenic Candida species differ in salt tolerance. Krauke Y1, Sychrova H.(PubMed)
(258) DISSOCIATION OF CANDIDA ALBICANS BY LITHIUM CHLORIDEAND IMMUNE SERUM by Mickle WA1, Jones CP.(PubMed)
(259) A sodium carbonate-bicarbonate buffer for alkaline phosphatases by DELORY GE, KING EJ (PubMed))260) The relationship between the acid and alkaline phosphatase activity and the adherence of clinical isolates of Candida parapsilosis to human buccal epithelial cells by Fernanado PH1, Panagoda GJ, Samaranayake LP.(PubMed)
(260) Candida albicans Rim13p, a protease required for Rim101p processing at acidic and alkaline pHs by Li M1, Martin SJ, Bruno VM, Mitchell AP, Davis DA.(PubMed)
(261) Adaptation to environmental pH in Candida albicans and its relation to pathogenesis. Davis D1.(PubMed)
(262) Effect of sodium bicarbonate on Candida albicans adherence to thermally activated acrylic resin by Sousa FA1, Paradella TC, Koga-Ito CY, Jorge AO.(PubMed)
(263) Synthesis and antimicrobial activity of dimethyl- and trimethyl-substituted phosphonium salts with alkyl chains of various lengths by A Kanazawa, T Ikeda, and T Endo(PubMed)(264) Antimicrobial Polymeric Materials with Quaternary Ammonium and Phosphonium Salts by Xue Y1,2, Xiao H3, Zhang Y4.(PubMed)
(265) Zinc and the immune system by Rink L1, Gabriel P.(PubMed)
(266) The immune system and the impact of zinc during aging by Haase H1, Rink L.(PubMed)

The Foods That Kill Prostate Cancer Cells, Scientists Say

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
(The revised article)

The widespread of prostate cancer, once considered a disease of aging male, now have become major concerns of governments and scientific community in South East Asian with tendency to effect even younger age population.

Evidences in the Far East recent diet suggested,  over consuming bad fats in any time in history accompanied with unhealthy diet and life style may be the possible causes of the disease, linking to the economic prosperity over last 3 decades.

Prostate cancer is a medical condition characterized by irregular cell growth in the prostate tissue.

At the later state, the cancerous cells may travel a distance away from the original site to infect other healthy tissue or organ.

Most prostate cancers are slow growing. And Enlarged prostate and prostate cancer in most cases are  detected during physical (rectum) exams.

Some researchers suggested that certain abnormal expression of hormones may have a strong effect in increased risk of prostrate cancer, including high levels of hormone androgen and  insulin-like growth factor-1 (IGF-1).

In other words, patients with prostate cancer are linearly associated to high levels of hormonal testosterone and insulin-like growth factor-1 (IGF-1).

Although genetic mutation may have a direct effect in induced prostate cancer incidence, such as BRCA1, BRCA2, MSH2 and MLH1, the direct causes of prostate cancer are still debatable.

However, there are some risk factors that have significant impacts to induce early onset of the disease.

The list include, age, family history, race, low levels of vitamin D in blood, excessive alcohol drinking, obesity,..... and enlarge prostate.

Foods That Kill Prostate Cancer Cells include
1. Flaxseed
Flax seed is native to the region of the eastern Mediterranean to India and also known as common flax or linseed.

Flax is an erect annual plant that can grow to 1.2 m tall. The leaves are 20–40 mm long and 3 mm broad.

Enterolactone and enterodiol, mammalian lignans derived from dietary flaxseed may obstruct or delay the progressed prostate cancer cell proliferation via vascular endothelial growth factor(VEGF)-associated pathways(76). And, diet supplemented with 5% flaxseed inhibited the growth and development of prostate cancer in the TRAMP model(77) and lowered prostate cancer proliferation rates associated with biological alterations(78).

2. Vegetable oil
Vegetables oil is a triglyceride extracted from egetables.

Increased levels of MUFA-rich vegetable oil((including olive oil, canola or peanut oil)) intake were associated with a progressive reduction in prostate cancer risk(79).

Hydrogenated soybean oil (SHSO) showed remarkably strong anticarcinogenic activity against prostate cancer in the rat model. And, 5% dietary supplementation with SHSO inhibited the growth of prostate cancer by 80% in vivo(80).

3. Honey
The rich golden liquid is the miraculous product made by bees using nectar from flowers. The liquids are considered as one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

Chrysin, a natural flavone commonly found in honey, and honey itself showed to exert its antiproliferative effect on PC-3 cells in a dose- and time-dependent manners(81).


4. Chickpea
Garbanzo beans also known as chickpea is an edible legume of genus Cicer, belongings to the family Fabaceae, with high sources of protein and mineral, native to Middle East.

7 protease inhibitor concentrates (PICs) isolated from chickpea showed a significant inhibition the LNCaP prostate cancer cells in concentrations tested of 25-400 μg/ml(82).

5. Olive oil
Extra virgin olive oil (EVOO), was found to significantly affect the growth of HCT 116 tumours xenografted in athymic mice(83).

And polyphenols, found in extra virgin olive oil (EVOO) exerted chemopreventive effects towards different organ specific cancers, through disruption of overall process of carcinogenesis by inhibition of DNA synthesis and ROS production, regulation of cell cycle arrest and modulation of survival/proliferation pathways(84).

Moreover, polyphenols application can directly interact with specific steps and/or proteins regulating the apoptotic process in different ways, depending on their concentration, the cell system, the type or stage of the pathological process(85).

6. Black pepper
Black pepper, is a flowering vine in the family Piperaceae, used as a spice and seasoning.

Piperine, a major alkaloid constituent of black pepper, inhibited the proliferation of LNCaP, PC-3, 22RV1 and DU-145 prostate cancer cells in a dose dependent manner.

And, In caspase activation in LNCaP and PC-3 cells(86) and β-caryophyllene oxide (CPO), a sesquiterpene isolated from essential oil of black pepper(Piper nigrum L.) not only inhibited the constitutive activation of PI3K/AKT/mTOR/S6K1 (anti-apoptosis and increased cell proliferation and nutrient–hormonal signaling network) pathway signaling cascade but also down-regulated the expression of various downstream gene products that mediate cell proliferation (cyclin D1), survival (bcl-2, bcl-xL, survivin, IAP-1, and IAP-2), metastasis (COX-2), angiogenesis (VEGF), and increased the expression of p53 and p21(87).

7. Green tea
Green tea containing more amount of antioxidants than any drinks or foods with the same volume, is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China.

Green tea catechins (GTCs), a potent chemical constituent containing (-)-epigallocathechin, (-)-epicatechin, (-)-epigallocatechin-3-gallate, (-)-epicatechin-3-gallate, in treatment of preprostate cancer men reduced lower urinary tract symptoms, improved coexistent benign prostatehyperplasia and reached a statistical significance in the case of International Prostate Symptom Scores(88).

In green tea polyphenols study, epigallocatechin-3-gallate (EGCG) exerted its anti PCa(89) effect by modulation of signaling pathways.

Also, combination of quercetin and green tea, showed a significant increase in inhibition of proliferation, androgen receptor and phosphatidylinositol 3-kinase/Akt signaling(tumor genesis in early stage), and stimulation of apoptosis(90).

In short, Green tea, a potent anti prostate cancer with activities of heritable alterations of gene expression and chromatin organization without changes in DNA sequence induced multistep processes of carcinogenesis(91) may be considered as a natural treatment in vary types of cancer.

8. Organic fermented soybean products
Fermented soybean products are made from fermenting soybeans and filamentous fungus, along with water and salt after a period of sometimes.

In the Japan, incidence of prostate caner in aging men are low in compared to the West.

This result may be due to tradition Japanese diet in exertion of prostate cancer protective effects

In fact, Traditional Japanese diet rich in soybean products and fish are associated to reduced prostate cancer risk(92).

In China, lower risk of prostate cancer are associated with consumption of soy foods and isoflavones found abundantly in fermented soybean products(93).

 Unfortunately, the epidemiological data, linking ferment soybean products to reduced risk of prostate cancer are inconsistent including miso.

Conclusion
The prevalence and widespread of prostate cancer may be diet, demographic and life style related disease(94)(95)(96).

Eating healthy, with plenty of vegetables and fruits has always been considered as a preventive approach. "Let foods be your medicine and let medicine be your foods" by Greek physician Hippocrates (460-377 BC).


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

References
(76) Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer by Azrad M, Vollmer RT, Madden J, Dewhirst M, Polascik TJ, Snyder DC, Ruffin MT, Moul JW, Brenner DE, Demark-Wahnefried W.(PubMed)
(77) Effect of flaxseed supplementation on prostatic carcinoma in transgenic mice BY Lin X, Gingrich JR, Bao W, Li J, Haroon ZA, Demark-Wahnefried W.(PubMed)
(78) Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery by Demark-Wahnefried W, Polascik TJ, George SL, Switzer BR, Madden JF, Ruffin MT 4th, Snyder DC, Owzar K, Hars V, Albala DM, Walther PJ, Robertson CN, Moul JW, Dunn BK, Brenner D, Minasian L, Stella P, Vollmer RT.(PubMed)
(79) Men who consume vegetable oils rich in monounsaturated fat: their dietary patterns and risk of prostate cancer (New Zealand) by Norrish AE, Jackson RT, Sharpe SJ, Skeaff CM.(PubMed)
(80) Selectively hydrogenated soybean oil exerts strong anti-prostate cancer activities by Jung MY, Choi NJ, Oh CH, Shin HK, Yoon SH.(PubMed)
(81) Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3 by Samarghandian S, Afshari JT, Davoodi S.(PubMed)
(82)Chickpea (Cicer arietinum) and other plant-derived protease inhibitor concentrates inhibit breast and prostate cancer cell proliferation in vitro. by Magee PJ, Owusu-Apenten R, McCann MJ, Gill CI, Rowland IR.(PubMed)
(83) Analgesic, anti-inflammatory and anticancer activities of extra virgin olive oil by Fezai M, Senovilla L, Jemaà M, Ben-Attia M(PubMed).
(84) Modulatory effects of polyphenols on apoptosis induction: relevance for cancer prevention by D'Archivio M, Santangelo C, Scazzocchio B, Varì R, Filesi C, Masella R, Giovannini C.(PubMed)
(85) Apoptosis in cancer and atherosclerosis: polyphenol activities by Giovannini C, Scazzocchio B, Varì R, Santangelo C, D'Archivio M, Masella R.(PubMed)
(86) Piperine, a Bioactive Component of Pepper Spice Exerts Therapeutic Effects on Androgen Dependent and Androgen Independent Prostate Cancer Cells by Samykutty A, Shetty AV, Dakshinamoorthy G, Bartik MM, Johnson GL, Webb B, Zheng G, Chen A, Kalyanasundaram R, Munirathinam G.(PubMed)
(87) β-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation by Park KR, Nam D, Yun HM, Lee SG, Jang HJ, Sethi G, Cho SK, Ahn KS.(PubMed)
(88) Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study by Bettuzzi S, Brausi M, Rizzi F, Castagnetti G, Peracchia G, Corti A.(PubMed)
(89) Modulation of signaling pathways in prostate cancer by green teapolyphenols by Khan N, Mukhtar H.(PubMed)
(90)Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea by Wang P, Vadgama JV, Said JW, Magyar CE, Doan N, Heber D, Henning SM.(PubMed)
(91) Epigenetic effects of green tea polyphenols in cancer by Henning SM, Wang P, Carpenter CL, Heber D.(PubMed)
(92) A case-control study of diet and prostate cancer in Japan: possible protective effect of traditional Japanese diet by Sonoda T, Nagata Y, Mori M, Miyanaga N, Takashima N, Okumura K, Goto K, Naito S, Fujimoto K, Hirao Y, Takahashi A, Tsukamoto T, Fujioka T, Akaza H.(PubMed)
(93) Soy and isoflavone consumption in relation to prostate cancer risk in China by Lee MM, Gomez SL, Chang JS, Wey M, Wang RT, Hsing AW.(PubMed)
(94) Soy intake and cancer risk: a review of the in vitro and in vivo data by Messina MJ, Persky V, Setchell KD, Barnes S.(PubMed)
(94) Mediterranean Diet and Prostate Cancer Risk and Mortality in the Health Professionals Follow-up Study by Kenfield SA, Dupre N, Richman EL, Stampfer MJ, Chan JM, Giovannucci EL.(PubMed)
(95) A prospective study of demographics, diet, and prostate canceramong men of Japanese ancestry in Hawaii by Severson RK, Nomura AM, Grove JS, Stemmermann GN.(PubMed)
(96) Alcohol consumption, smoking, and other risk factors and prostate cancer in a large health plan cohort in California (United States) by Hiatt RA, Armstrong MA, Klatsky AL, Sidney S.(PubMed)

Do You Know How to Determine the Severity of Allergic Reactions

By Kyle J. Norton, Scholar, Master of Nutrition

Allergy is the over reaction of immune system to harmless substances after entering our body affecting 1 in every 3 people.

Allergy is defined as the type I reactions or Immediate Hypersensitivity as a result of
over production of Immunoglobulin E (IgE), a class of allergic antibody by the immune system against harmless substance with an aim to mediate release of histamine and other mediators from mast cells and basophils, that lead to allergic reaction, including mucus secretion, sneezing, itching, etc.

Food allergy is a result of over production of antibody Immunoglobulin E (IgE) of immune system in responding to harmless ingredients in the foods such as peanut, shrimp, crayfish, lobster, walnuts, peanuts, soy, legume, etc., after eating.

Food allergy is severe food intolerance, in some cases, it may be fatal or hospitalized.

A. Food allergy can be classified into 2 types, depending to the length of the reaction of the immune system
1. Fixed food allergy
Fixed food allergy is defined as symptoms of allergy appeared immediately as soon as the allergic food is eaten.
2.  Marked (Cyclic) allergies
This types of allergic symptoms may taken longer to take effects, usually hour or days after the allergic food is eaten. Coiled foods allergy affects 90% of the patient of all cases.

B. How to determine the severity of the allergic effects
Depending to the allergy stimulating effect, some researchers suggested to scale the severity from 1 to 4 and followed by degeneration scale, but from -1 to -4
1. The severity scale from +1 to +4
+1. The first level of stimulation
If there is no symptoms at all or If the patient is alert and function morally after allergic is eaten
+2. The second level of stimulation
The patient have become irritable, hyperactive, tense, thirsty, etc. after a suspected allergic foods is eaten
+3. The third level of stimulation
The patient have become hypomanic, aggressive, apprehensive, etc.
+4. The fourth level of stimulation
The patient have become mania, agitation, over excitement, etc.

Other severity scale may also be use for all allergies, such as  1-6. 6 being the most severe. I think 0 is non allergic.

2. Degeneration scale from -1 to -4
-1. If a patient is experience symptoms of reaction of runny nose, hive, diarrhea, etc.
-2. If a patient is experience symptoms of reaction of tiredness, fatigue, swelling etc.
-3. If a patient is experience symptoms of reaction of depression, mental disturbance, confusion, mood change, etc.
-4. If a patient is experience symptoms of reaction of sever depression, paranoia, etc.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca



Kyle J. Norton(Scholar, Master of Nutrition), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources

(1) How Far Can We Control the Severity of Food Allergic Reaction by Controlling Exposure to Allergenic Foods? ILSI Europe Workshop, 16 September 2016, Brussels
(2) Allergy DiagnosisReference Guide