A Food That Protects Cell Integrity And DNA Transcription Against Most Types Of Cancer Onset, Medline Studies Revealed

Kyle J. Norton, Scholar, Master of Nutrition

Adding a portion of dried beans into your diet, may have a potential effect in reduced risk of cancers onset, according to the Division of Cancer Prevention, National Cancer Institute.

Dried beans are nutritionally mighty member of the legume family, belongings to the family Fabaceae.

The  healthy sources of dried legume, including protein, fibers, vitamins and minerals such as dietary fiber, fat, protein, vitamin A ( beta carotene, lutein and zeaxanthin), B vitamins, vitamin C, calcium, iron, magnesium, phosphorus, potassium, ...  and zinc can be included in anyone diet,

Certain genetic mutations may have significant influences in risk of cancers, such as BRCA1 and BRCA2 genes which can elevate risk of breast and ovarian cancers. 

According to statistic, women who carry mutated gene BRCA1 and 2 have a 50 to 85 percent increased risk of developing the disease by age of 70.

Other causes of cancer are unknown, however, researchers suggested that smoking and use of tobacco, unhealthy diet, family history, inactive physical activity, long term exposure to sun and other types of radiation, infected viruses,        and infectious diseases are some of potential risk factors that may have a strong impact on the development of cancers.

Cancer is a class of diseases characterized by cell growth  uncontrollably and disorderly, affecting all the organs and tissue.

Depending to its invasive nature, some cancers can travel a distance away from the original site to infect other parts of the body.

In the study to investigate 490,802 United States participants of the NIH-AARP Diet and Health cohort using Cox proportional hazard models adjusted for potential confounders and during 2,193,751 person years of follow-up from 1995/1996-2000, researchers found that
*. Intake of vegetables shows a significant effect in reduced risk of certain types of cancer.

* The relative hazard ratio risk of cancers was reduced to .95 in compared to control

*. Risk of cancers is reduced substantially as shown in highest tertile of leguminosae group (dried beans, string beans and peas, 0.80, 0.67-0.96) in compared to other groups.

Dried bean and string bean with abundant fiber scored the lower and lowerest relative risk ratio in compared to peas and other kinds of vegetables.

Further analysis of diets of African-American men and women, undergoing colonoscopies in order to examine the relationship between selected dietary factors and the risk for colon polyps, according to the multiple logistic regression model used to adjust for potential confounding variables and to determine which factors influence colorectal adenoma risk, researchers said, " consumption of legumes such as dried beans, split peas, or lentils was negatively associated with risk (of cancers)" and "Legumes are a good source of dietary fiber and of phytochemical compounds that may play a role in reducing adenoma formation or growth".

Once again, dried beans exerted a highest effect in reduced risk of colorectal adenoma in compared to other types of legume.

Interestingly, in broaden scope of further exploration of the association between legume intake and cancer risk in a case-control study of 11 cancer sites in Uruguay between 1996 and 2004, including 3,539 cancer cases and 2,032 hospital controls, researchers suggested, intake of legume including dried peas demonstrate a substantially decreased risk of stomach and prostate cancer and other forms of cancer, including
*. Cavity and pharynx cancer had a relative odd risk ratio of OR=0.48

*. Esophagus cancer with OR = 0.54

*. Larynx cancer with OR = 0.55

*. Upper aerodigestive tract cancer with OR = 0.50

*. Stomach cancer with OR = 0.69

*. Colorectum cancer with OR = 0.43

*. Kidney cancer relative had odd risk ratio of .OR = 0.41

* With relative odd risk ratio of .68 on all sites combined


After adjusting to other risk factors researchers concluded, "Higher intake of legumes was associated with a decreased risk of several cancers including those of the upper aerodigestive tract, stomach, colorectum, and kidney, but not lung, breast, prostate or bladder".

These results suggested that the protective effect of dried beans in inhibited most types of cancer occurrence may be a result of improvement of  host cells integrity against alternation of  cells DNA transcription in induction of cancer.


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Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca




Sources
(1) Legume intake and the risk of cancer: a multisite case-control study in Uruguay by Aune D1, De Stefani E, Ronco A, Boffetta P, Deneo-Pellegrini H, Acosta G, Mendilaharsu M.(PubMed)
(2) Legume intake and reduced colorectal adenoma risk in African-Americans by Agurs-Collins T1, Smoot D, Afful J, Makambi K, Adams-Campbell LL.(PubMed)
(3) Fruit and vegetable intake and head and neck cancer risk in a large United States prospective cohort study by Freedman ND1, Park Y, Subar AF, Hollenbeck AR, Leitzmann MF, Schatzkin A, Abnet CC.(PubMed)

Detoxification: Time To Detox, If You Experience Some Of These Symptoms

By Kyle J. Norton, Scholar, Master of Nutrition

Our body toxins are removed by some vital organs such as the liver, kidney and skin.

If one of these organs starts to malfunction, others must take the toxins and remove them.

In cases of our body cannot completely remove all the toxins, toxins will  be accumulated in the organs and tissue, leading to weakening of organs and tissue function in induction of chronic diseases.

1. The Liver
The liver plays a major role in metabolism.
It is among the few internal human organs capable of natural regeneration of lost tissue.
Liver has a vital function in removing toxins in our body, such as overdose of medication, vitamin A and other substances damages the normal function.
Symptoms of a weakened liver include:
a) Arthritis
b) Pale or Brittle nails
c) Unable to sleep
d) Bitter taste in the mouth
e) Limited muscle flexibility

Some of the herbal medicine may have a significant effect to promote liver function in eliminated toxins from our body including, milk thistle, a flower plant of the daisy family has been used in traditionally medicine for treatment of chronic liver disease.

The herbal medicine contains silymarin with impressive functions in protected liver function and expelled liver toxins.

In a study to compare Cirsium japonicum DC's flavonoids, liver protection against liver toxicity using carbon tetrachloride (CCl4) with silymarin as a positive control, researchers after taking into account of other co and founders found that silymarin exerts a clear hepatoprotective effect similar to those of Cirsium japonicum DC's flavonoids against toxins caused by injection of carbon tetrachloride (CCl4)(1)


2. The Kidneys
Works together with the Liver in removing toxins from our diet including overdose of medication through urinary extraction.

The kidneys also make hormones that control blood pressure, bone maintenance, and the production of red blood cells. Most cases of kidney disease are caused by high blood pressure, kidney inflammation and hardening of arterial walls.

Symptoms of a weakened kidney include:
a) Sexual dysfunction
b) Mental retardation
c) Low grade back pain
d) Weakness of knee and leg
e) Frequent urination


According to the University of Southern California, antioxidant phenolic compounds such as tannins, flavonoids, isoflavonoids, unsaturated organic acids and lignans; circulation enhancing compounds like saponins, and basic alkaloids with multiple targets (G-protein coupled receptors) nay have a profound and positive effect in improved kidney function(2).

The other compounds with properties in exertion of proinflammatory and antiinflammatory activities may also be included in these groups, such as fatty acids like linoleic (n-6) and α-linolenic (n-3) acids(2).

And these compounds can be found in many of Chinese herbal plants(2).

Dr. Lien EJ, the lead author said, "Attention is also drawn to the plants containing nephrotoxic aristolochic acid. Different directions of future research are also presented. We hope that this review may provide some leads for new drug (with kidney protective effect ) discovery and development, and more rational application of TCM"(2)..


3. The Skin
Skin is the largest organ of the integumentary system made up of multiple layers of epithelial tissues.

 It also is the third system with function to expel toxins from our body, if the liver and kidney cannot completely remove them.

Symptoms of toxic skin include:
a) Skin rashes caused by vitiligo and psoriasis
b) Red, itchy rash
c) Inflammation
d) Temporary disability

Duchesnea indica (Rosaceae family), used extensively in traditional Chinese medicine for treatment of varieties of disease and syndrome may have potential effect in protected skin against toxic substance accumulation.

According to the Kangwon National University, methanolic extract of D. indica (DIM) protected the skin toxicity through increasing the antioxidants levels of the host by utilized antioxidant in the extract and antioxidants produced enzymes in the body tissue.

Dr. Hu W, the lead scientist said, "Pretreatment of CCD-986Sk cells with methanolic extract of D. indica (DIM) improved the cell viability, enhanced activity of catalase, and decreased the leakage of lactate dehydrogenase (LDH) and the levels of malondialdehyde (MDA) and intracellular reactive oxygen species (ROS) in H(2)O(2) injured cells"(3).


4. The Intestine (except colon)
Intestine includes 2 parts 
 * The small intestine is further subdivided into the doudenum, jejunum and ileum. it helps to digest materials passing through and from where nutrients are absorbed.

* The large intestine is subdivided into the cecum and colon with unique function in absorbed water from digested material and any nutrients that may have escaped primary digestion in the ileum.
Symptoms of dysfunction of the intestine include:
a) Abdominal pain
b) Peripheral vision losses, night vision losses
c) Weight loss
d) Upset stomach, fever, earache, headache
e) Bowel obstruction
f) Muscle spasms and cramps

Sipjeondaebo-tang, a traditional herbal medicine formula, used to improve immune system against invasion of foreign pathogens., may be a potential herbal medicine in promoted gastrointestinal performance.

Application of Sipjeondaebo-tang water extract (SDTW; 200 mg/kg of body weight) to rats 2 h before the oral administration of absolute ethanol to induced dastric mucosal injury exerted a gastric protective effect by decreased the damage via conditioning the gastric mucosa, such as hemorrhage, hyperemia(4).

The results of these activities were observed by significantly reduced MDA concentration and  increased GSH contents and the activities of antioxidant enzymes(4).

Dr. Woo-Young Jeon, the lead scientists said, "In an acute toxicity study, no adverse effects of SDTW were observed at doses up to 5000 mg/kg/day"(4).

5. The Colon
The colon is the last portion of the digestive system.

It also has a function in extracted water and salt from solid waste before eliminating them from the anus.

Symptoms of a malfunctioning colon include:
a) Memory loss
b) Inability to concentrate and confusion
c) Joint pain
d) Weakening the colon's ability to properly eliminate all the waste materials
f) Autointoxication or self-poisoning.


Composition of extracts of 3 herbs medicine (Atractylodis Rhizoma Macrocephalae, Massa Medicata Fermentata, and Dolichoris Semen) has been known to exert GI protective activities
According to the study in evaluation of gut microbial niche by antibiotics like neomycin in produced gastrointestinal (GI) disorders conducted by the Dongguk University-Seoul, application of mixture augmented stool water content, decreased fecal population of Lactobacillus spp., changed the histology of intestine without inducing inflammation, reduced the colonic expression of zonula occludens-1 (ZO-1) and claudin-1, a marker of presence of bacteria, against neomycin-induced digestive dysfunction(5).

Dr. Bose S, the lead author said, "The combined treatment with any of the above agents ameliorated the histological changes of cecum and colon in neomycin-treated rats, and the magnitude of this effect was probiotic > HF-2 > HF-1"(5).

6. The Blood
If the liver, kidney and skin cannot completely remove toxins, they will be accumulated in the blood stream, causing inflammation of blood vessels and buildup of plaque.

Symptoms of poisoned blood include:
a) Illusion
b) Confusion
c) Black Stew
d) Black skin
e) Inflammation

According to the Dongguk University Seoul, Rhizoma Atractylodis Macrocephalae, Massa Medicata Fermentata, and Dolichoris Semen are Chinese herbal medicine used for treatment of symptoms induced by inflammation .

In LPS-mediated inflammatory insult, either individually in vitro using RAW264.7 cells or in combination in in vivo using rats, application of individual herb exerted a significantly anti-inflammatory activity through strongly attenuated the blood endotoxin and CRP levels, as well as the gut permeability, and significantly augmented the intestinal Lactobacillus spp. colonisation in LPS-treated rats(6).

 Lipopolysaccharide (LPS) is known to produce endotoxic shock by triggering systemic inflammatory responses.

7. Lung
The lung is the essential respiration organ with function in transported oxygen into the bloodstream, and released carbon dioxide from the bloodstream into the atmosphere.

Symptoms of a weakened lung include:
a) Build-up of mucus
b) Irritation of the eyes, nose, throat, lips and tongue
c) Blockage of air way
d) Sudden illness
e) Chronic cough
f) Tiredness or depression


In the study to analyze whether Esculentoside A (EsA), a saponin isolated from the Chinese herb Phytolacca esculenta with lung protective effect against lipopolysaccharide (LPS)-induced acute lung injury (ALI) researchers at the Jilin University found that injection of EsA shows marked effects by reducing inflammatory infiltration, thickening of the alveolar wall, and pulmonary congestion and decreases levels of tumor recrosis factor α and inflammatory factor interleukin 6 which are elevated by LPS(7).

After taking into account of other co and con con founders, Dr. Zhong WT, the lead researcher said, "EsA suppressed inflammatory responses in LPS-induced ALI through inhibition of the nuclear factor kappa B and mitogen activated protein kinase signaling pathways"(7).

Nuclear factor kappa B are signalling proteins with function in activated production of inflammatory cytokines.

Mitogen activated protein kinase signaling pathways are family of proteins with functions involved  numbers of fundamental cellular processes such as proliferation, differentiation, motility, stress response, apoptosis, and survival.

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Sources
(1) Hepatoprotective effect of flavonoids from Cirsium japonicum DC on hepatotoxicity in comparison with silymarin by Ma Q1, Wang LH, Jiang JG(PubMed)

(2) Phytochemical analysis of medicinal plants with kidney protective activities by Lien EJ1, Lien LL, Wang R, Wang J.(PubMed)
(3) Protective effect of the methanolic extract from Duchesnea indica against oxidative stress in vitro and in vivo by Hu W1, Han W, Huang C, Wang MH(PubMed)
(4) Gastroprotective effect of the traditional herbal medicine, Sipjeondaebo-tang water extract, against ethanol-induced gastric mucosal injury by Woo-Young Jeon, In-Sik Shin, Hyeun-Kyoo Shin, and Mee-Young Lee(PubMed)
(5) Intestinal Protective Effects of Herbal-Based Formulations in Rats against Neomycin Insult by Bose S1, Han KW, Lee MJ, Kim H(PubMed)
(6) In vitro and in vivo protective effects of fermented preparations of dietary herbsagainst lipopolysaccharide insult by Bose S1, Song MY, Nam JK, Lee MJ, Kim H(PubMed)
(7) Protective effect of esculentoside A on lipopolysaccharide-induced acute lunginjury in mice. by Zhong WT1, Jiang LX, Wei JY, Qiao AN, Wei MM, Soromou LW, Xie XX, Zhou X, Ci XX, Wang DC.(PubMed)

Infectious Disease: Beware Of Some Life Threatening And Chronic Complications Associated To Over Growth of Candida

By Kyle J. Norton

Candida albicans are members of a large group of micro organism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.

Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).

 In many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and over expression of genes(9)(10) are often associated with increased Candida resistance toward antifungal agents.

According to the article of Health Line, the causes of over growth of candida include over use of antibiotics in the vagina,  pregnancy, uncontrolled diabetes. weak immune system,....... and lack of sleep.


Some life threatening and chronic implications of candida overgrowth
1. Toxic shock syndrome(TSS)
Candida overgrowth can cause toxic shock syndrome (TSS)(157), a potentially fatal illness by producing toxins to suppress the immune system(158)(159), leading to infectious cause of high fever, accompanied by confusion, extreme fatigue and weakness, headache, severe diarrhea, sore throat, vomiting, widespread red rash, coma(161), and multiple organ failure(160).

2. Scalded skin syndrome (SSS)
Scalded skin syndrome is defined as a condition of skin infection inducing damage to the skin with marked shedding due to toxins(162) released by candida in suppressing the immune system(162).

Depending on severity, it can causes bloodstream infection(163) and electrolyte imbalance, involved in regulate myocardial and neurological function(164), fluid balance(165), oxygen delivery, etc., resulting in high morbidity and mortality(166).

Chronic diseases
3. Irritable Bowel Syndrome (IBS)(167)(168)
As the condition worsen, candida takes advantage of weakness immune system and imbalances in the digestive system, allowing fungus to overrun the digestive tracts(169), leading to gases which irritate the intestinal and stomach linings(171) and initiated pain(170)(172).

4. Chronic Sinusitis(173)
As candida growth occurs in the sinus cavities(173), it causes fungal serious infections, with symptoms of nasal congestion, facial pain, pressure, congestion, or fullness, reduced or absent sense of smell. Both chronic and acute fungal sinusitis require immediate treatment(174).

5. Fibromyalgia
Fibromyalgia syndrome is a chronic condition that causes intense pain in various places around the body, including muscles, connective tissues and joints, as well as a host of other symptoms, as a result of production of mycotoxins by overgrowth candida(175), causing autoimmune diseases(143)(144)(136) by triggering inflammation in the intestinal tract(151).

Fibromyalgia syndrome affects more than 6 million people in the United States.

6. Chronic Fatigue Syndrome
Chronic fatigue syndrome (CFS) is defined as a health condition of persistent fatigue unrelated to exertion, it interferes with the patient daily activity, causing trouble staying on top of their responsibilities at home and on the job, etc.(176) due to production of mycotoxins by overgrowth candida(177)(178), triggering inflammation(179) in the intestinal tract.

Symptoms of chronic fatigue syndrome include headache, tender lymph nodes, fatigue, weakness, muscle, joint aches, inability to concentrate,(180) etc.

7. Thrush
Thrush is defined as condition of infection of the mouth caused by over growth candida fungus(181)(182).

8.  Eczema, or Atopic Dermatitis
Eczema is a general term for many types of skin inflammation (dermatitis). The most common form of eczema is atopic dermatitis in some cases caused by over growth of candida(183)(184) as a result of immune suppressive factors(185).

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Holistic System In Existence That Will Show You How To
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References
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ.(PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeastspecies. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMerd)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(157)Effect of strain of Staphylococcus aureus on synergism with Candidaalbicans resulting in mouse mortality and morbidity. Carlson E.(PubMed)
(158)Lesson of the month 2: toxic shock syndrome.
Shalaby T1, Anandappa S2, Pocock NJ2, Keough A2, Turner A2.(PubMed)
(159)Staphylococcal toxic shock syndrome: superantigen-mediated enhancement of endotoxin shock and adaptive immune suppression. Kulhankova K1, King J, Salgado-Pabón W.(PubMed)

(157)Effect of strain of Staphylococcus aureus on synergism with Candidaalbicans resulting in mouse mortality and morbidity. Carlson E.(PubMed)(158)Lesson of the month 2: toxic shock syndrome. Shalaby T1, Anandappa S2, Pocock NJ2, Keough A2, Turner A2.(PubMed)(159)Staphylococcal toxic shock syndrome: superantigen-mediated enhancement of endotoxin shock and adaptive immune suppression. Kulhankova K1, King J, Salgado-Pabón W.(PubMed)
(160) Toxic Shock Syndrome, C health(161)Group A streptococcal toxic shock syndrome with extremely aggressive course in the third trimester. Sugiyama T1, Kobayashi T, Nagao K, Hatada T, Wada H, Sagawa N.(PubMed).
(162) Scalded skin syndrome, the university of Maryland medical center(163)Candida bloodstream infections in intensive care units: analysis of the extended prevalence of infection in intensive care unit study. Kett DH1, Azoulay E, Echeverria PM, Vincent JL; Extended Prevalence of Infectionin ICU Study (EPIC II) Group of Investigators.(PubMed)
(164) [Infectious and metabolic nervous system complications of systemic cancer].[Article in Spanish]Ortiz N1.(PubMed)
(165) [Voriconazole compromises renal function in an elderly CDK patient with Candida albicans infection].[Article in Italian] Anastasio P1,.(PubMed)
(166)Endogenous thrombospondin-1 regulates leukocyte recr Marcarelli F, Bilancio G, Mele AA, De Santo NGuitment and activation and accelerates death from systemic candidiasis. Martin-Manso G1, Navarathna DH, Galli S, Soto-Pantoja DR, Kuznetsova SA, Tsokos M, Roberts DD.(PubMed)
(167) [Life-threatening complications of Crohn's disease and ulcerative colitis: a systematic analysis of admissions to an ICU during 18 years]. [Article in German] Huber W1, Herrmann G, Schuster T, Phillip V, Saugel B, Schultheiss C, Hoellthaler J, Gaa J, Hartel M, Schmid RM, Reindl W.(PubMed)
(168)The role of Candida albicans in the pathogenesis of food-intolerant irritable bowel syndrome. Shepherd C.(PubMed)
(169) Yeasts in the gut: from commensals to infectious agents. Schulze J1, Sonnenborn U.(PubMed)
(170) Treatment of abdominal pain in irritable bowel syndrome. Vanuytsel T1, Tack JF, Boeckxstaens GE.(PubMed)
(171) Current gut-directed therapies for irritable bowel syndrome. Chang HY1, Kelly EC, Lembo AJ.(PubMed)
(172) Abdominal pain in Irritable Bowel Syndrome: a review of putative psychological, neural and neuro-immune mechanisms.Elsenbruch S1.(PubMed)
(173) [Changes of etiology of chronic sinusitis].[Article in Chinese] Deng Q1, Peng P.(PubMed)
(174)Invasive fungal sinusitis of the sphenoid sinus. Lee DH1, Yoon TM1, Lee JK1, Joo YE2, Park KH3, Lim SC1.(PubMed)
(175) Occurrence of killer yeasts in isolates of clinical origin. Robledo-Leal E1, Villarreal-Treviño L, González GM.(PubMed)
(176)Experiences of daily activity in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) and their implications for rehabilitation programmes. Pemberton S1, Cox DL.(PubMed)
(177) Chronic illness associated with mold and mycotoxins: is naso-sinus fungal biofilm the culprit? Brewer JH1, Thrasher JD, Hooper D.(PubMed)
(178) Detection of mycotoxins in patients with chronic fatigue syndrome.Brewer JH1, Thrasher JD, Straus DC, Madison RA, Hooper D.(PubMed)
(179) Exposure to zearalenone mycotoxin alters in vitro porcine intestinal epithelial cells by differential gene expression.Taranu I1, Braicu C2, Marin DE3, Pistol GC3, Motiu M3, Balacescu L2, Beridan Neagoe I2, Burlacu R4.(PubMed)
(180)Therapeutic effects of oral NADH on the symptoms of patients with chronic fatigue syndrome.
Forsyth LM1, Preuss HG, MacDowell AL, Chiazze L Jr, Birkmayer GD, Bellanti JA.(PubMed)
(181) Identification of Candida albicans genes induced during thrush offers insight into pathogenesis. Cheng S1, Clancy CJ, Checkley MA, Handfield M, Hillman JD, Progulske-Fox A, Lewin AS, Fidel PL, Nguyen MH.(PubMed)
(182) Is endometrial infection with Candida albicans a cause of recurrent vaginal thrush?Smith JR1, Wells C, Jolly M, Shah P, Savage M, Reginald P, Kitchen VS.(PubMed)
(183) Candida albicans-specific lymphoproliferative and cytokine (IL-4 and IFN-gamma) responses in atopic eczema dermatitis syndrome. Evidence of CD4/CD8 and CD3/CD16+CD56 ratio elevations in vitro. Kosonen J1, Luhtala M, Viander M, Kalimo K, Terho EO, Savolainen J.(PubMed)
(184) Candida albicans mannan- and protein-induced humoral, cellular and cytokine responses in atopic dermatitis patients. Savolainen J1, Kosonen J, Lintu P, Viander M, Pène J, Kalimo K, Terho EO, Bousquet J.(PubMed)
(185) Guidelines for treatment of atopic eczema (atopic dermatitis) Part II.
Ring J1, Alomar A, Bieber T, Deleuran M, Fink-Wagner A, Gelmetti C, Gieler U, Lipozencic J, Luger T, Oranje AP, Schäfer T, Schwennesen T, Seidenari S, Simon D, Ständer S, Stingl G, Szalai S, Szepietowski JC, Taïeb A, Werfel T, Wollenberg A, Darsow U; European Dermatology Forum; European Academy of Dermatology and Venereology; European Task Force on Atopic Dermatitis; European Federation of Allergy; European Society of Pediatric Dermatology; Global Allergy and Asthma European Network.(PubMed)

Beware of Environment Toxins In Increased Substantially Risk Of Early Onset Of Dementia As We Age

According to the research of Alzheimer's Research UK, 1 in 3 people born in the UK this year will develop dementia in their lifetime.

Approximately, over 850,000 people with dementia in the UK and these numbers will increase by over 1 million by year of 2025.

The  prevalent risk of dementia have escalated substantially in the East due to economic prosperity over last 30 years in increased living standard of population over a billion.

As a large percentage of these population are followers of Western diet as they have made a lots of money in compared to others and the past.

Dementia is the loss of mental ability that is severe enough to interfere with people's every day quality of life.

And, Alzheimer's disease is the most common type of dementia in aging people.

Western diet process high amount of saturated and trans fat, artificial ingredients with less fruits and vegetable can lead to dementia and other kinds of chronic ailment.

Certain environment toxins produced as a result of industrialization or naturally have been linked to cognitive degenerative diseases.

Researchers at the University of British Columbia in the investigation of Novel environmental toxins: steryl glycosides as a potential etiological factor for age-related neurodegenerative diseases, showed that mice fed washed cycad flour show signs that mimic amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS-PDC), including progressive deficits in motor, cognitive, and olfactory functions associated with neuron loss in the spinal cord, nigrostriatal system, cortex, hippocampus, and olfactory bulb.

Through a series of chemical extractions of washed cycad flour, researchers identified steryl glycoside molecules as bioactive molecules that are neurotoxic in culture and in mice.

A detailed review of this class of molecule revealed that the molecules are abundant in the environment, particularly in plants and bacteria.

 Lipid analysis showed that some bacteria that are associated with some forms of neurodegenerative disorders have the capacity to synthesize steryl glycosides.

Furthermore, certain steryl glycosides have been found to be a cell stress mediator and may have some immunomodulary effects.(1).

Others researchers suggested that Parkinson disease (PD) and Alzheimer disease (AD), are of purely genetic origin in a minority of cases and appear in most instances to arise through interactions among genetic and environmental factors and early environmental origins of neurodegenerative disease in later life(2).

1. Polychlorinated biphenyls (PCB)
Polychlorinated biphenyls (PCB) are industrial chemicals used commercially 1929 and ended in the United States in the 1970s for the manufacturing of electrical equipment, heat exchangers, hydraulic systems, etc.

Researchers at the Emory University in sex-specific analyses revealed that women had an excess of amyotrophic lateral sclerosis after exposing to the toxic chemicals,

Furthermore, women highly exposed to the chemicals at work are associated to an excessive risk of Parkinson disease and dementia(3).

Other study suggested chronic inhalation of low chlorinated PCBs that involved elevated blood levels was associated with a subtle attenuation of emotional well-being and attentional function.

Extended research is needed to replicate the potential long-term low PCB effects in a larger sample.(4)

2. Pesticides
Pesticides is the substances used in preventing, destroying, repelling or mitigating any pest.

 In the study to exposure to pesticides in related to central nervous system disorders of a prospective cohort study of 1,507 French elderly (1992-1998), researchers suggested neurologic impairments are highly presented in elderly persons who were exposed occupationally to pesticides in compared to general population(5).

Other study of 917 subjects interviewed from February 1997 to August 1998, 528 who were directly exposed to pesticides through mixing and/or spraying (mean exposure duration: 22 years), 173 were indirectly exposed through contact with treated plants, and 216 were never exposed, scientist strongly agreed that long-term cognitive effects also found in people with low-level exposure to pesticides in occupational conditions(6).

3. Cyanobacterial toxins
Cyanobacterial toxins produced by bacteria cyanobacteria have been linked to neurodegemerative disorders.

According to the Laboratoire de Neurobiologie Cellulaire et Moléculaire, cyanobacterial massive proliferation is a public concern regarding the capacity of certain cyanobacterial strains to produce hepatotoxic and neurotoxic compounds, such as beta-N-methylamino-l-alanine(BMAA) that can affect public health, human activities and wild and stock animals.

BMAA is associated to various forms of neurodegenerative disorder.

4. Mixtures of organic solvents
In the study to assess the applicability of the World Health Organization (WHO) Neurobehavioral Core Test Battery (NCTB) of 53 male and 29 female Venezuelan workers exposed to mixtures of organic solvents in an adhesive factory, incompared to 56 male and 11 female workers unexposed to any type of neurotoxic chemical, research team at University of Carabobo found that compared to the nonexposed, the exposed subjects demonstrated an increased frequency of subjective symptoms of fatigue, difficulties with memory, confusion, abnormal sensation in upper and lower extremities, and sleep disturbances(8)


5. Dioxins and heavy metals
In the study to evaluate the roles of dioxins and heavy metals in cancer and neurological diseases, researchers suggested that dioxins exert toxic actions by deceasing action of antioxidant enzymes such as superoxide dismutase, and glutathione peroxidase in protect cells integrity against cancer and neuronal dysfunction.

Heavy metals manifest cytotoxic effects in various cells and tissues.

Tight regulation of metals is essential to the health to general public.

Cadmium modulates gene expression and signals transduction and reduces activities of proteins involved in antioxidant defense, interfering with DNA repair and modifying cancer development and brain function.

Cobalt promotes generation of reactive oxygen species in induction of DNA damage in cells and brain tissues, altering abnormal cells proliferation and differentiation and causing healthy cells apoptosis.

Copper is a key metal in cell division processes in both normal and tumor cells.

Copper also has been shown to have an positively important role in neurodegenerative diseases such as Alzheimer disease, Parkinson disease, and amyotrophic lateral sclerosis.(9)

6. Asbestos
There are report that Asbestos has been kinked to Alzheimer disease. 10 cases in which an asbestos-related disease (malignant pleural mesothelioma or asbestosis) was associated with severe Alzheimer type lesions in the brain(10).

Although toxic substances have been banned over last 10 years, the environment ejected from these substances are stills a major concern in inflicted public health issues.

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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/17149752
(2) http://www.ncbi.nlm.nih.gov/pubmed/16140633
(3) http://www.ncbi.nlm.nih.gov/pubmed/16357589
(4) http://www.ncbi.nlm.nih.gov/pubmed/16236166
(5) http://www.ncbi.nlm.nih.gov/pubmed/12615605
(6) http://www.ncbi.nlm.nih.gov/pubmed/11564621
(7) http://www.ncbi.nlm.nih.gov/pubmed/19660486
(8) http://www.ncbi.nlm.nih.gov/pubmed/7900732
(9) http://www.ncbi.nlm.nih.gov/pubmed/20696237
(10) http://www.ncbi.nlm.nih.gov/pubmed/3957626

Digestive Disorders: How To Optimize Gastrointestinal Performance By Augmented Functions of Digestive Antioxidant and Enzymes, Medline Studies Suggest

By Kyle J. Norton, Scholar, Master of Nutrition

 Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Andrographis paniculata may have potential and profound effects in improved the gastric tone and prevented gastric dysfunction through the protection of its antioxidants and activation of digestive enzymes, some scientists suggested.

Andrographis paniculata is also known as andrographis is a herbaceous plant, genus Andrographis, belongings to the family Acanthaceae, native to India and Sri Lanka.

The forgotten herb has been used in traditional Siddha and Ayurvedic for treating common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, ....

Gastroprotective effect is am action involved enhancing the function of digestive system against the harmful organisms in induced chronic digestive disorder.

People with digestive problem may experience certain stomach discomfort, including bloating. constipation. diarrhea. heartburn, nausea and vomiting,.......and belly pain.

Untreated digestive problems over a long term can induce serious ailments of chronic illnesses, as the digestive system no longer performs it's function in provided nutrients and fluids to the needs of body's cells and tissue..

The results of malnutriments over a long period of time can lead to weakened immune defense and reduced levels of antioxidants produced by tissue of the body in fighting against pathogens, 

Most common chronic illness associated to malnutriments are gastroenteritis, arthritis, asthma, cancer, COPD, diabetes and some viral diseases such as hepatitis C and HIV/AIDS infections,

The David M and Lynda K Underwood Center for Digestive Disorders, suggested "experiments in animal models have revealed the extent to which the gut microbiota sustains health and how its disruption might contribute to disease pathogenes".

As digestive problem has altered the balance of the gut microbiome in the gastrointestinal tract.

Dr. Matthew J. Bull, the lead scientist in the discuss of The Human Gut Microbiome in Health and Disease suggested, "Imbalance of the normal gut microbiota have been linked with gastrointestinal conditions such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), and wider systemic manifestations of disease, such as obesity, type 2 diabetes, and atopy".

Although, genetic mutation of certain genes, such as MyD88 gene, Dectin-1 gene, NLRP12 Gene and NOD2 gene (Readers who want to know more of gene implication on digestive disorders may search in PubMed with key word, "gene mutation and digestive disorder") are association with non-specific digestive disorder, the cause of digestive problem in some cases are not restricted to digestive tract but  symptoms of wider systemic problems.

Some researchers suggested the physical causes of digestive disorder including food allergies and food intolerance, unhealthy diet, viral or bacterial infection, certain digestive diseases,...... and Inflammation and auto-immune diseases.

Further more, ageing also has a strong impact on digestive problem, as we age, the production of saliva decreases that can affect the taste, worsen acid reflux and increase risk of digestive diseases.
 

In the study of gastric ulcer induced by ethanol, aspirin, pylorus ligation and cold restraint stress models in rats, researchers at the  the Bharathi Women's College.found that  rats treated or pretreated with hydroalcoholic extract HAEAP (100,200,500mg/kg b. wt for 30 days) of andrographis paniculata demonstrate a significant ulcer reduction, in dose dependent manner.

The ulcer preventing effect of HAEAP may be a result of its bioactive compound in regulating the gastric hydrogen potassium ATPase, also known as H+/K+ ATPase, an enzyme with functions to acidify the stomach activity and stimulating mucosal defensive system at the mucosal surface of the gastrointestinal tract..

Additional analysis of the results, researchers found that the flavonoids present in the HAEAP might be responsible for the gastroprotective action probably by maintaining the antioxidants and thiol status in the gastrointestinal tract.

In support of the above differentiation, the review of a period of 1 year from 2014-2015, using semi-structured questionnaires from different traditional Bengali people having knowledge on medicinal plants, out of 49 plants under 46 genera belonging to 33 families, researcher indicated that andrographis paniculata is one of the most prominent plants used among the people of Southern Assam for treating digestive system disorders (DSD).

Moreover,  seed ethyl acetate, acetone and methanol extracts of andrographis paniculata (Burm.f.) Wall. ex Nees has drawn a lots of scientist attention due to the limit success of chemical anthelmintics, a group of antiparasitic drugs (levamisole, flubendazole, and thiabendazole) in reduced gastrointestinal diseases.

In animal controls, injection of ED(50), an methanol extract of A. paniculata at dose of 2.90 mg/ml, and in larval development assay at ED(50) of dose 4.26 mg/ml, showed significant effects against sheep parasites, Haemonchus contortus.

Taking altogether, there is no doubt that andrographis paniculata consists a strong gastroprotective effect against the activities of harmful organisms, including parasites and may be used as functional food in improving digestive functions.

However, additional data collection on clinical studies performed with human consumption on large sample size and multi centers during the course of diseases will be necessary to complete the picture of andrographis paniculata effects in complete the treatment possibilities.

Intake of andrographis paniculata extract in any forms should be taken with extreme care in prevention of acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) A biochemical study on the gastroprotective effect of hydroalcoholic extract ofAndrographis paniculata in rats by Panneerselvam S, Arumugam G(PubMed).
(2) Plant utilization against digestive system disorder in Southern Assam, India by Choudhury PR1, Choudhury MD1, Ningthoujam SS2, Mitra A1, Nath D3, Talukdar AD4.(PubMed)
(3) Anthelmintic activity of botanical extracts against sheep gastrointestinalnematodes, Haemonchus contortus by Kamaraj C1, Rahuman AA, Elango G, Bagavan A, Zahir AA.(PubMed)
(4) Gut microbiome as a clinical tool in gastrointestinal disease management: are we there yet by Quigley EMM(PubMed)
(5) Part 1: The Human Gut Microbiome in Health and Disease by Matthew J. Bull, BSc, PhD and Nigel T. Plummer, PhD(PubMed)

Scientists Discovered A Potent And Natural Alternative to Anti Depressants Without Inducing Any Side Effects

Kyle J. Norton, Master of Nutrition


The use of plants for healing purposes have been predated long before the existence of modern medicine.

Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......


Depression is a normal response as part of our daily lives such as the loss of s job, the death of a love one, and illness, affecting the way you eat, sleep, and the way you feel about yourself.

Over 30 million Americans suffer from depression and the amount is increasing in an alarming rate.

According to general belief, people who suffer from depression may experience some mental and physical symptoms, observed by screen assay for depression in clinical settings.

The most common mental symptoms are feeling sad without reason and guilty, emotionally out of control, trouble concentrating or remembering, lack of motivation, having negative thoughts,...., particularly, in loss of interest in usual pleasurable activities.

And most common physical symptoms include lack of energy or fatigue, difficulty performing daily activities, changes in sexual desire, appetite,.... particularly, in change of sleep pattern or difficult to sleep.

In concern to the causes of depression, researchers do not know why some people are more susceptible to the syndrome while some don't. However, depression may associate to a lots of different factors that affect our mental health.

According to the mapping risk factors for depression across the lifespan, the development of depression may involve a complex interplay of environmental and genetic risk factors including widowhood, physical abuse during childhood, obesity, having 4-5 metabolic risk factors, sexual dysfunction, job strain and with  ino consistent evidence for the causal effects of obesity, smoking, and alcohol consumption(4).

If you are experience some of the above symptoms, you may be at the early onset of depression. Please make that you see the related field specialist immediately.

If you are taking  conventional antidepressants, such as sertraline (Zoloft), fluoxetine (Prozac, Sarafem) citalopram (Celexa), escitalopram (Lexapro), paroxetine (Paxil, Pexeva, Brisdelle), fluvoxamine (Luvox), please make sure you know the adverse effects such as increased appetite, weight gain, loss of sexual desire, fatigue, drowsiness, insomnia. dry mouth, blurred vision, constipation,.....

Green tea may have a profound effect in reduced risk and treatment of depression, some scientists suggested

Green tea, a precious drink processes numbers of health benefit, known to almost everyone in Asia and Western world.

However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

In vivo, application of green tea(GT) and GABA green tea (GGT) expressed a protective activity of against post-stroke depression (PSD), a common consequence of stroke, according to joint study lead by the Pavia University.

And, in mouse model of post-stroke depression, GGT and GT enhance the activity in the modulation of depressive symptoms through decreased oxidative stress, increased antioxidant endogenous defenses, including polyphenol, theanine, glutamine, etc......

Also, according to a cross-sectional study of consumption of green tea and coffee ascertained with a validated dietary questionnaire and the amount of caffeine intake estimated from these beverages, conducted by the joint venture lead by the Fukuoka Women's University, green tea consumption is associated to reduce symptoms of depression, depending to amount of intake.

Compared amount intake,  participants consumed ≥4 cups green tea/d had a 51% significantly lower prevalence odds of having depressive symptoms than those consumed less than 1 cup/d.

The multiple-adjusted odds for depressive symptoms comparing the highest with the lowest quartile of caffeine consumption was 0·57.

These results suggested that green tea consumption have a linear effect correlated to numbers of cup intake per day without mentioning the effects of maximum cups that patients can take.

Dr. Pham NM, the lead author in the study said, "higher consumption of green tea, coffee and caffeine may confer protection against depression".

Furthermore, in the review of Embase, PubMed, and Chinese National Knowledge Infrastructure databases from their inception through August 2014, tea consumption of more than 3 cups a day showed a significant decrease the risk of depression of 37% (RR = 0.63, 95% CI: 0.55-0.71), in compared to individuals with lower tea consumption and those with higher tea consumption.

Taking together, there is no doubt, green tea may be used as a functional food in reduced symptoms and risk of depression if consumes daily.

However, oral administration of large amount daily should be taken with care, particular to people with yin constituent.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Green tea and coffee consumption is inversely associated with depressivesymptoms in a Japanese working population by Pham NM1, Nanri A1, Kurotani K1, Kuwahara K1, Kume A1, Sato M2, Hayabuchi H3, Mizoue T1.(PubMed)
(2) Antidepressive-like effects and antioxidant activity of green tea and GABA green tea in a mouse model of post-stroke depression by Di Lorenzo A1, Nabavi SF2, Sureda A3, Moghaddam AH4, Khanjani S4, Arcidiaco P5, Nabavi SM2, Daglia M1.(PubMed)
(3) Effect of green tea on reward learning in healthy individuals: a randomized, double-blind, placebo-controlled pilot study by Zhang Q1, Yang H, Wang J, Li A, Zhang W, Cui X, Wang K.(PubMed)
(4) Mapping risk factors for depression across the lifespan: An umbrella review of evidence from meta-analyses and Mendelian randomization studies by Köhler CA1, Evangelou E2, Stubbs B3, Solmi M4, Veronese N5, Belbasis L6, Bortolato B7, Melo MCA1, Coelho CA1, Fernandes BS8, Olfson M9, Ioannidis JPA10, Carvalho AF(PubMed)

Beware: Poor Diet Cause Early Onset of Dementia, as We Age Revealed By Medline Studies

By Kyle J. Norton

Dementia is a condition of  neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement, chronically

Over 47 millions of worldwide population are afflicted by the diseases, mostly in the West.

The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.

According to Alzheimer society of Canada, beside aging, people with diabetes, high blood pressure, obesity, smoking, depression, cognitive inactivity, and physical inactivity are susceptible to substantial risk of dementia onset.

In a prospective cohort study conducted in Caerphilly, South Wales, United Kingdom. Men aged 45-59 years, to examine whether caloric intake in mid-life is associated with later dementia or cognitive impairment not dementia (CIND) by the University of Bristol, researchers found that age adjusted odds ratios demonstrated strongest associations between average energy consumption and vascular CIND or dementia.

The results suggested aging population who follow poor diet are at increased risk dementia in compared to younger adult group, although, when adjusted for social class, the observed association between caloric intake and cognitive outcomes is modest.

Midlife characteristics of nonsmoking, body mass index (BMI) less than 25.0 kg/m(2), physically active, and having a healthy diet (based on alcohol, dairy, meat, fish, fruits, vegetables, cereals, and ratio of monounsaturated tosaturated fat) are associated to reduce risk of dementia(132).

Poor diet causes of dementia
1. Saturated fat and Trans fat(145)
Saturated fat is important for energy, hormone production, cellular membranes, especially in signalling and stabilization processes in the body, but over consumption can cause cholesterol building up in the arteries, leading to heart diseases, stroke, diabetes, etc.

A high saturated fat and cholesterol intake has shown to increase the risk of dementia, whereas fish consumption may decrease this risk(135)(145), probably due to involvement in the β-oxidation process of long-chain fatty acids, very-long-chain fatty acids, and branched-chain fatty acids of peroxisome(133)(145) in the breaks down molecules into smaller units to release energy of very long chain fatty acids(134).

 Intake of trans fat is also found to potentially increase the AD risk or cause an earlier onset of the disease due to its effects in increased production of amyloid beta (Aβ) peptides, main components of senile plaques(136).

2. Artificial sweetener
Artificial sweetener can cause obesity risk of dementia independence of diabetes and cardiovascular comorbidities(137). and induced increasing consumption of fat(138).

3. Fast Foods
Fast foods, unwholesome foods, containing high amounts of artificial ingredients, with an aim to be cooked fast and handed over to the customer in minutes may induce anxiety, tension, depression, difficulty in concentration, and memory, that can lead to onset of senile dementia(139).

4. Artificial ingredients
A standard American diet containing high amount of MSG and aspartame may induce the early onset of neurodegenerative disease(140)

5. Alcohol
Moderate alcohol drinking is associated with a reduced risk of unspecified incident dementia and AD(141)(145), however, excessive consumption of alcohol not only causes liver damage but also increases risk of neuro-degeneration, including onset of dementia due to its neurotoxic and neuroprotective effect(142).

6. Low intake of fruits and Vegetables
Nutrition plays a role in the ageing process of the brain and suboptimal nutrient.

According to The Chinese University of Hong Kong, older people with questionable dementia have lower intakes of vegetables, fruits(145) and fluid than those who were cognitively normal(143)

7. Meat
The typical American diet containing high amounts of red meat has shown to increase risk of cholesterol building up in the blood vessels and capillaries in causation of heart diseases and stroke(144) and cognitive impairment(135).


Natural Medicine for Fatty Liver And Obesity Reversal – The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299


References
(135) Dietary fat intake and the risk of incident dementia in the Rotterdam Study by Kalmijn S1, Launer LJ, Ott A, Witteman JC, Hofman A, Breteler MM.(PubMed)
(136) Trans fatty acids enhance amyloidogenic processing of the Alzheimer amyloid precursor protein (APP) by Grimm MO1, Rothhaar TL, Grösgen S, Burg VK, Hundsdörfer B, Haupenthal VJ, Friess P, Kins S, Grimm HS, Hartmann T.(PubMed)
(137) Can artificial sweeteners help control body weight and prevent obesity? by Benton D1.(PubMed)
(138) Central obesity and increased risk of dementia more than three decades laterby R. A. Whitmer, PhD, D. R. Gustafson, PhD, E. Barrett-Connor, MD, M. N. Haan, DrPH, E. P. Gunderson, PhD and K. Yaffe, MD(Neurology)
(139) Evaluation of diet and life style in etiopathogenesis of senile dementia: A survey study. by Chaudhuri K1, Samarakoon SM, Chandola HM, Kumar R, Ravishankar B.(PubMed)
(140) WHERE CTE, DIET, and NEURODEGENERATION MEET(Reversing disease for optimal health)
(141) Alcohol drinking, cognitive functions in older age, predementia, and dementia syndromes by
Panza F1, Capurso C, D'Introno A, Colacicco AM, Frisardi V, Lorusso M, Santamato A, Seripa D, Pilotto A, Scafato E, Vendemiale G, Capurso A, Solfrizzi V.(PubMed)
(142) Alcohol and cognition in the elderly: a review by Kim JW1, Lee DY, Lee BC, Jung MH, Kim H, Choi YS, Choi IG.(PubMed)
(143) Lower fluid and fruits/vegetable intake in questionable dementia among older Hong Kong Chinese.by Lee J1, Lam L, Woo J, Kwok T.(PubMed)
(144) Meat consumption in relation to mortality from cardiovascular disease among Japanese men and women by Nagao M1, Iso H, Yamagishi K, Date C, Tamakoshi A.(PubMed)
(145) Alcohol consumption in mild cognitive impairment and dementia: harmful or neuroprotective? by Panza F1, Frisardi V, Seripa D, Logroscino G, Santamato A, Imbimbo BP, Scafato E, Pilotto A, Solfrizzi V.(PubMed)