Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Tuesday, 10 October 2017

Herbal Therapy: Andrographis, The Best Whole Herb Medicine for Treatment of Ulcerative Colitis

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Whole food ingredients in herbal plant have been found to process some significant effects in reduced risk and treatment of certain diseases, but single ingredient isolated from such plants may induce opposite outcomes.
Andrographis paniculata expressed a significant efficacy similar to those of mesalamine, for treatment of ulcerative colitis, a study by renowned institute suggested.

Ulcerative colitis is condition of inflammatory bowel disease (IBD) inducing long-lasting inflammation and ulcers in the digestive tract.

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,....

In a randomized, double-blind, placebo-controlled trial in evaluated the efficacy of A. paniculata extract (HMPL-004) in 224 adults with mild-to-moderate ulcerative colitis. with patients randomized to A. paniculata extract (HMPL-004) 1,200 mg or 1,800 mg daily or placebo for 8 weeks, patients treated with A. paniculata extract (HMPL-004) at a dose of 1,800 mg daily achieve clinical response than those receiving placebo.

The study also discovered that 60 and 53% of patients treated with A. paniculata groups experienced adverse effect at doses of 1,200 mg and 1,800 mg daily respectively in comparison to 60% in the placebo group.

Dr. Sandborn WJ, the lead author in the study said, "Andrographis paniculata has in vitro inhibitory activity against TNF-α, IL-1β and NF-κB. A pilot study of A. paniculata extract (HMPL-004) suggested similar efficacy to mesalamine for ulcerative colitis."

Other study involved herbal extract HMPL-004 also support the use of herbal extract for treatment in patients with mild-to-moderate ulcerative colitis, according to the randomised, double-blind, multicentre, 8-week parallel group study conducted using HMPL-004 with 1200 mg/day in compared with 4500 mg/day of slow release mesalazine (mesalamine) granules in same group.

In fact, in comparison to mesalazine, HMPL-004 exhibited a 21% and 76% of more efficacy in treated patients, compared to 16% and 82% of mesalazine-treated patients through the colonoscopy, remission and response.

Although HMPL-004 may be an efficacious alternative to mesalazine in treating ulcerative colitis, the herbal medicine can only prescribed by herbalist to prevent overdose toxicity.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Andrographis paniculata extract (HMPL-004) for active ulcerative colitis by Sandborn WJ1, Targan SR, Byers VS, Rutty DA, Mu H, Zhang X, Tang T.(PubMed)
(2) Randomised clinical trial: herbal extract HMPL-004 in active ulcerative colitis - a double-blind comparison with sustained release mesalazine by Tang T1, Targan SR, Li ZS, Xu C, Byers VS, Sandborn WJ.(PubMed)

Food Therapy: Maternal Coffee Intake in Reduced Risk of β-cell autoimmunity in New Born

By Kyle J. Norton

In compared to herbal medicine, food therapy even takes longer to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Coffee, becoming a popular and social beverage all over the world, particularly in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

Maternal consumption of coffee may have a profound effect in reduced risk of β-cell autoimmunity inducing Type 1 diabetes in the offspring, according to the University of Tampere.

In a prospective Finnish birth cohort of 4297 infants with human leukocyte antigen (HLA)-DQB1-conferred susceptibility to type 1 diabetes with lbood samples collected from the children at 3-12 months intervals to measure type 1 diabetes-associated antibodies against islet cells (ICA), insulin, glutamate dehydroxylase, and islet antigen 2, returned questionnaire from mothers indicated that intake of coffee during perchance expresses a inversely associated risk of development of advanced β-cell autoimmunity in their infants.

Even after adjusting to other risk factors, coffee showed a linearly dependent to amount of cups intake of the mothers against risk of β-cell autoimmunity incidence in newborns.

Additionally, in the review of data comprised 4297 children with increased genetic susceptibility to type 1 diabetes, born at the University Hospital of Oulu or Tampere, Finland, between October 1997 and December 2002 monitored for diabetes-associated autoantibodies from samples obtained at 3-12-mo intervals, returned surveys from mothers indicated that coffee increased antioxidant status have a a significant effect in reduced risk of advanced beta cell autoimmunity development in children, compared to substantial risk of the offspring in mother who did not intake any antioxidant dietary nutrients.

Further more, Dr. Uusitalo L, the lead researcherssaid, "the hazard ratios, indicating the change in risk per a 2-fold increase in the intake of each antioxidant, were nonsignificant and close to 1" and "High maternal intake of retinol, beta-carotene, vitamin C, vitamin E, selenium, zinc, or manganese does not protect the child from development of advanced beta cell autoimmunity in early childhood".

Interestingly, the returned questionarre from participants in the data from a population-based case-control study with incident cases of adult onset (≥ 35 years) diabetes, including 245 cases of latent autoimmune diabetes in adults (glutamic acid decarboxylase antibody positive), 759 cases of Type 2 diabetes (glutamic acid decarboxylase antibody negative), together with 990 control subjects without diabetes, randomly selected from the population, researchers found that intake of coffee may have enormous effect in reduced risk of type 2 diabetes, but conversely, coffee intake showed to associate to elevated risk of autoimmunity and possibly an increased risk of Type 1-like latent autoimmune diabetes in these group of adults.

Dr. Löfvenborg JE, the lead author in above study said, " for every additional cup of coffee consumed per day, there was a 15.2% (P = 0.0268) increase in glutamic acid decarboxylase antibody levels".

Taking altogether, There is no doubt that coffee consumption during pregnancy has a substantial effect in attenuated risk of type 1 diabetes caused by advanced β-cell autoimmunity. But coffee consumed in adulthood may increased risk of Type 1-like latent autoimmune diabetes adults. contrastively.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Maternal food consumption during pregnancy and risk of advanced β-cell autoimmunity in the offspring by Virtanen SM1, Uusitalo L, Kenward MG, Nevalainen J, Uusitalo U, Kronberg-Kippilä C, Ovaskainen ML, Arkkola T, Niinistö S, Hakulinen T, Ahonen S, Simell O, Ilonen J, Veijola R, Knip M.(PubMed)
(2) Intake of antioxidant vitamins and trace elements during pregnancy and risk of advanced beta cell autoimmunity in the child by Uusitalo L1, Kenward MG, Virtanen SM, Uusitalo U, Nevalainen J, Niinistö S, Kronberg-Kippilä C, Ovaskainen ML, Marjamäki L, Simell O, Ilonen J, Veijola R, Knip M.(PubMed)
(3) Coffee consumption and the risk of latent autoimmune diabetes in adults--results from a Swedish case-control study by Löfvenborg JE1, Andersson T, Carlsson PO, Dorkhan M, Groop L, Martinell M, Rasouli B, Storm P, Tuomi T, Carlsson S.(PubMed)

33 Admirable Health Benefits of Herbal Chaste tree berry(Vitex agnus-castus)

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Herbal Therapy: Chaste tree berry, The Best Antinociceptive Functional Food

Kyle J. Norton

Whole food ingredients in herbal plant have been found to process some significant effects in reduced risk and treatment of certain diseases, but single ingredient isolated from such plants may induce opposite outcomes.

A recent study suggested that essential oil isolated from Chaste tree berry mayhave a potential effect in reduced neuro-pain through antinociceptive function in tested subjects.
Antinociceptive effect is the activity in reduced pain through interference with information transmitted and received of brain neurons.

Interestingly, the extract of herbal medicine also displayed a strong effect against chronic inflammation in induced pain.

The joint study lead by the Federal University of Santa Maria suggested that crude extract caused antinociceptive/antidepressant-like effects in the CFA-induced chronic inflammation model in comparable to naloxone, without altered inflammatory parametersat doses of 10mg/kg,

This result indicated that The VmE extract demonstrated pain relief through inducing opioid-dependent antinociception and antidepressant-like effects, without anti-inflammatory activity.

Further more, in the investigated petroleum ether fraction (PEF) from the aqueous ethanol extract of Chaste tree berry in several nociceptive mouse models, mouses treated with the fraction produced significant dose-related inhibitions on chemical nociception in comparable to Naloxone (1 mg/kg bw subcutaneously), a non-selected opioid receptor antagonist.

In xylene-induced ear edema test, the fraction also exerted a strong analgesic effects partially mediated by its anti-inflammatory activity.

Taking together, Chaste tree berry may have a therapeutic potential to be used as antinociceptive functional food in reduced pain through blocking the information transfer by neurotransmitters.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Antinociceptive effects, acute toxicity and chemical composition of Vitex agnus-castus essential oil by Khalilzadeh E, Vafaei Saiah G, Hasannejad H, Ghaderi A, Ghaderi S, Hamidian G, Mahmoudi R, Eshgi D, Zangisheh M.(PubMed)
(2) Antinociceptive and antidepressant-like effects of the crude extract of Vitexmegapotamica in rats by Hamann FR1, Zago AM2, Rossato MF3, Beck VR4, Mello CF4, de Brum TF5, de Carvalho LM6, Faccin H6, Oliveira SM7, Rubin MA8(PubMed)
(3) Antinociceptive activities of the liposoluble fraction from Vitex negundo seeds by Zheng CJ1, Huang BK, Han T, Zhang QY, Zhang H, Rahman K, Qin LP.(PubMed)

Monday, 9 October 2017

Herbal Therapy: Chaste Tree Berry, The Whole Herb Medicine for Prevention and Treatment of Cataract

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Whole food ingredients in herbal plant have been found to process some significant effects in reduced risk and treatment of certain diseases, but single ingredient isolated from such plants may induce opposite outcomes.

Recent study suggested that Chaste Tree Berry may be used to modulate risk and treatment of selenite induced cataractogensis.

Furthermore, the study also found that Chaste tree berry also expresses a significant improvement of chaperone property of α-crystallin and soluble protein levels in two dimensional-polyacrylamide gel electrophoresis (2D-PAGE) and immunoblot analysis.

Dr. Rooban BN, the lead author said, " FVN modulated selenite induced cataractogensis in rat pups by preventing loss of chaperone property, various changes in lens proteins, and lens structure, further strengthening its protective role".

Some researchers suggested that the efficacy of chaste tree berry in reduced risk and treatment of cataract may be a result of phytochemical antioxidants activity in scavenge free radicals cause of the disease, as oxidative stress, loss of calcium homeostasis, calpain activation and protein insolubilization are found to associate to cataract patients.

More importantly, in a study of eight-day-old Sprague-Dawley rat pups divided into four groups: Control (G I), Sodium selenite-induced (G II), Sodium selenite+quercetin treated (G III), Sodium selenite+flavonoids from Vitex negundo (FVN) (G IV), group fed with sodium selenite+flavonoids showed normal levels of expression of lens of water soluble proteins in compared to other groups.

In fact, fed treated with FVN showed to exhibite the antioxidant effects in modulating biochemical parameters against selenite-induced cataract, the University of Kerala insisted.

In support to the above differentiation, the Sprague-Dawley rat pups of 8 days old divided into control (G I), selenite induced (G II), and selenite + V. negundo treated (G III) with cataract induced by the single subcutaneous injection of sodium selenite (4 mg/kg body weight) on the tenth day and V. negundo (2.5 mg/Kg body weight) administered intraperitoneally from eighth to 15th day study, group III showed to exert reduced activities of superoxide dismutase, catalase, lower level of reactive oxygen species, Ca(2+), and thiobarbituric acid reactive substance significantly.

Taking together, Chaste tree berry may process of therapeutic potential used for prevention and treatment of cataract with mild adverse effects.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Analysis on the alterations of lens proteins by Vitex negundo in selenite cataract models by Rooban BN1, Sasikala V, Sahasranamam V, Abraham A.(PubMed)
(2) Vitex negundo attenuates calpain activation and cataractogenesis in selenite models by Rooban BN1, Lija Y, Biju PG, Sasikala V, Sahasranamam V, Abraham A.(PubMed)

Herbal Therapy: Andrographis, The Best Anti Platelet Aggregation Herbal Medicine

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

In Herbal medicine, symptoms of the diseases can only be eased gradually, depending to stage of the treatment which directly address to the cause of the disease.

A recent vitro study suggested that Andrographis paniculata exerted the enormous inhibitory effect on platelet aggregation.

Antiplatelet activity is the effect in decreased platelet aggregation and inhibited thrombus formation.

Due to inefficacy in applications of higher concentrations, Dr. said, "the extract with high level of AP(3) (Extract B) (IC(50) values=50-75 microg/ml) showed less inhibitory activity against thrombin than the extract with lower level of AP(3) (Extract A) (IC(50) values=25-50 microg/ml). These results indicate that the standardized A. paniculata extract may contain other antiplatelet compounds rather than AP(1) and AP(3), which contribute to high antiplatelet activity".

In comparison of platelet aggregation effects with non-steroidal antiinflammatory drugs (NSAID), treatment of the herbal medicine showed a strong influence on the biosynthesis of eicosanoids in cell signaling and the platelet-activating factor (PAF) with the ability to cause platelet aggregation, inflammation, and allergic response,...

The study also proposed that the mechanism of these actions may be associated with the cardiovascular and antithrombotic activity in compared to that of non-steroidal antiinflammatory drugs (NSAID),

Other study insisted that the effects of andrographolide in platelet activation may be a result of reducing the mortality of ADP-induced acute pulmonary thromboembolism and significantly prolonged platelet clumping formation of which decrease the platelet aggregation activity.

Taking together, there is no doubt that herbal Andrographis processes an anti Platelet Aggregation through exhibiting the functions of various mechanisms. People with bleeding disorder should only take the herbal medicine with permission of related field specialist.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Inhibitory effect of Andrographis paniculata extract and its active diterpenoids on platelet aggregation by Thisoda P1, Rangkadilok N, Pholphana N, Worasuttayangkurn L, Ruchirawat S, Satayavivad J.(PubMed)
(2) Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation by Amroyan E1, Gabrielian E, Panossian A, Wikman G, Wagner H.(PubMed)
(3) A novel role of andrographolide, an NF-kappa B inhibitor, on inhibition of plateletactivation: the pivotal mechanisms of endothelial nitric oxide synthase/cyclic GMP by Lu WJ1, Lee JJ, Chou DS, Jayakumar T, Fong TH, Hsiao G, Sheu JR.(PubMed)

Herbal Therapy: Chaste Tree Berry (Seeds), The Best in Relieved Symptoms and Treatment of Arthritis

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Whole food ingredients in herbal plant have been found to process some significant effects in reduced risk and treatment of certain diseases, but single ingredient isolated from such plants may induce opposite outcomes.
A renowned institute study suggested that seeds of Vitex negundo L. (Verbenaceae) may have potential effects for the treatment of rheumatism and joint inflammation.

In Freund's complete adjuvant (CFA) induced arthritis (AA) in rat model. oral administartion of treatment of Chaste Tree Berry seed expressed a strongly inhibited paw edema, reversed weight loss and decreased arthritis score.

According to the Second Military Medical University, the efficacy of herbal medicine for treatment of arthritis is the result in inhibition of pro inflammatory cytokins and in regulation of enzymes responsible for inflammation and pain.expression.

In support of the above, researchers in the examined hstopathological studies found that Chaste Tree Berry showed a remarkable inhibition effect in decreased synovial inflammatory infiltration and synovial lining hyperplasia in the joints in animal models.

Some also researchers suggested that Chaste tree berry reduced symptoms of pain of arthritis patient probably is associated to the blocking the stimulus by sensory neurons ability through mediating anti-inflammatory activity and interacted with the opioid system.

Taking together, Chaste Tree Berry (seed) processed an analgesic properties may be used as therapeutic potential in ameliorated symptoms and treatment of inflammatory arthritis. Large amount intake can only be prescribed by herbalists.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Therapeutic effects of standardized Vitex negundo seeds extract on complete Freund's adjuvant induced arthritis in rats by Zheng CJ1, Zhao XX1, Ai HW1, Lin B1, Han T1, Jiang YP1, Xing X2, Qin LP3.(PubMed)
(2) Antinociceptive activities of the liposoluble fraction from Vitex negundo seeds by Zheng CJ1, Huang BK, Han T, Zhang QY, Zhang H, Rahman K, Qin LP.(PubMed)