Saturday, 9 September 2017

Food Therapy: Coffee, the Gout Killer Functional Food

By Kyle J. Norton

People who turn to alternative medicine for treatment of disease in avoidance of adverse effects induced by conventional medicine should be patient. In compared to herbal medicine; food therapy even takes longer to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Good News for coffee lovers, coffee consumption daily is associated to reduced risk and treatment of
chronic and recurrent gout. a renowned institute proposed.

Gout mostly effected one joint, is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.

Coffee, becoming a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

According to the joint study lead by the Central South University, in the review literature of PubMed and EMBASE databases, up to April 2015, out of total of 11 observational studies (6 cross-sectional, 3 cohort and 2 case-control studies), coffee consumption showed a significantly inverse association with incidence of gout.

The study also found out that the efficacy of coffee consumption in reduced risk of gout showed no significant difference between the highest and the lowest coffee intake in terms of serum uric acid (SUA) level.

Additionally, in the total of 45,869 men with no history of gout at baseline with intake of coffee, decaffeinated coffee, tea, and total caffeine evaluated in every 4 years, participants in returned questionnaires  indicated that increasing coffee intake was (1-3, 4-5, and > or = 6 cups per day) inversely associated with the risk of gout depending to numbers of cups consumed daily.

The related risk of gout incidence in coffee drinkers is as low as .41 in compared to non coffee consumed participants.

Most importantly, the total caffeine levels from all sources, including coffee and tea intake showed no associated risk of gout.

Other researchers, in the finding of gout developed, suggested that coffee intake of 4 to 5 and >/=6 cups daily lower risk of gout in compared to no intake (0.26 mg/dl and and 0.43 mg/dl respectively) and total caffeine from coffee and other beverages and tea intake were not associated with serum uric acid levels.

Also, according to the data from 14,758 participants ages >/=20 years in the Third National Health and Nutrition Examination Survey (1988-1994), coffee consumption is associated to ameliorated serum uric acid level and hyperuricemia frequency.

Taking together, coffee consumption is associated to attenuated risk and treatment of gout caused by elevated serum uric acid level, depending to numbers of cup intake daily.


Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Is coffee consumption associated with a lower risk of hyperuricaemia or gout? A systematic review and meta-analysis by Zhang Y1, Yang T1, Zeng C1, Wei J2, Li H1, Xiong YL1, Yang Y1, Ding X1, Lei G1.(PubMed)
(2) Coffee consumption and risk of incident gout in men: a prospective study by Choi HK1, Willett W, Curhan G.(PubMed)
(3) Coffee, tea, and caffeine consumption and serum uric acid level: the third national health and nutrition examination survey by Choi HK1, Curhan G.(PubMed)

Food Therapy: Coffee, The Anti Edema Therapeutic Beverage?

By Kyle J. Norton

In compared to herbal medicine, food therapy may take longer than six months to ease symptoms, depending to stage of the treatment which directly address to the cause of disease.

Good news for coffee drinkers, coffee may have a potential effect in reduced risk and treatment of edema, a recent study suggested.

Edema is a condition characterized by excess fluid retained in body's tissues, inducing swelling.

Coffee, becoming a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

According to the joint study lead by the Kyung Hee University, chlorogenic acid (CGA) isolated from coffee exerted protective effects of transient middle cerebral artery occlusion (tMCAo) rat model in ameliorated brain infarct volume and brain water content.

The protective effect in reduced on ischemia-induced neuronal damage and brain edema.is attributed to dihydrocaffeic acid (DHCA, formed in metabolism of CGA in inhibited enzymes involved in the degradation of the extracellular matrix, namely MMP2 and MMP-9. in providing structural and biochemical support to the surrounding cells.

In a rat model of transient middle cerebral artery occlusion, CGA directly showed a significantly reduced brain water content, by the inhibitory effects on MMP-2 and MMP-9 activities.

The study also addressed that the attenuation of brain edema may also be effected by the chemical compound's anti lipid peroxidation (LPO) activity through increased antioxidant expression.

Other study in the investigation of anti-inflammatory activity against carrageenan, PGE(2) and serotonin-induced hind paw edema and 12-O-tetradecanoyl-13-acetate (TPA)-induced mouse ear edema models, chlorogenic acid (CGA), also exerted a significant anti-inflammatory and antinociceptive activity against serotonin-induced hind paw edema and TPA-induced mouse ear edema, researchers at the Gazi University postulated.

The findings suggested that coffee may be used as functional and therapeutic beverage for reduced risk and treatment of edema, more studies are necessary to confirm the promising validity.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Protective Effects of Dihydrocaffeic Acid, a Coffee Component Metabolite, on a Focal Cerebral Ischemia Rat Model by Lee K1, Lee BJ2, Bu Y3.(PubMed)
(2) Chlorogenic acid ameliorates brain damage and edema by inhibiting matrix metalloproteinase-2 and 9 in a rat model of focal cerebral ischemia by Lee K1, Lee JS, Jang HJ, Kim SM, Chang MS, Park SH, Kim KS, Bae J, Park JW, Lee B, Choi HY, Jeong CH, Bu Y.(PubMed)
(3) Ethnopharmacological evaluation of some Scorzonera species: in vivo anti-inflammatory and antinociceptive effects by Küpeli Akkol E1, Bahadır Acıkara O, Süntar I, Ergene B, Saltan Çitoğlu G.(PubMed)

Friday, 8 September 2017

28 Outstanding Health Benefits of Aloe Vera

By Kyle J. Norton

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It is very popular for commercial cultivation due to its health benefits, used in herbal medicine in lmany kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc.

Phytochemicals
The ten main areas of chemical constituents of Aloe vera include: amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols


28 Outstanding Health Benefits of Aloe Vera
1. Herbal Aloe Vera and Type II Diabetes
2. Herbal Aloe vera and Acne vulgaris
3. Herbal Aloe Vera and Gastric Ulcers
4. Herbal Aloe Vera and Cancers
5. Aloe Vera and Polycystic Ovarian Syndrome 
6. Herbal Aloe Vera and gingivitis
7. Herbal Aloe Vera and psoriasis 
8. Herbal Aloe vera and Irritable bowel syndrome
9. Herbal Aloe Vera and Skin diseases
10. Aloe Vera and Wound Healing
11. Herbal Aloe Vera and Immunity
12. Herbal Aloe Vera and Skin Aging
13. Herbal Aloe vera and Prostate cancer
14. Herbal Aloe vera and colon cancer
15. Aloe vera gel (AVG) and Polycystic Ovarian Syndrome (PCOs)
16. Herbal Aloe vera and lung cancer
17. Herbal Therapy: Aloe Vera, the Natural Whole Food Medicine for Reduced Aging Wrinkle
18. Herbal Therapy: Aloe Vera, the Natural Whole Food Medicine for Treatment of Ulcerative Colitis
19. Herbal Therapy: Aloe Vera, the Anti Constipation Natural Whole Food Medicine
20. Herbal Therapy: Aloe Vera, the Natural Whole Food Medicine in Anti Microbial effects
21. Herbal Therapy: Aloe Vera, the Natural Whole Food Medicine to Restore Normal Levels of Cholesterol
22. Herbal Therapy: Aloe Vera, the Neuroprotective Natural Whole Food Medicine
23. Herbal Therapy: Topical Aloe Vera, The best Whole Food Medicine for Treatment of Burn
24. Herbal Therapy: Aloe Vera, The Immunomodulatory Whole Food Medicine
25. Herbal Therapy: Aloe Vera, The Whole Food Medicine Exhibited Anti Hypertensive Effects
26. Herbal Therapy: Aloe Vera, the Natural Whole Food in Inhibited HSV-1(Herpes simplex) Activity
27. Herbal Therapy: Aloe Vera, the Natural Antioxidant Whole Food 
28. Herbal Therapy: Aloe Vera, the Natural Whole Food Medicine for Reduced Symptoms and Treatment of Oral Submucous Fibrosis


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Herbal Therapy: Aloe Vera, the Natural Whole Food Medicine for Reduced Symptoms and Treatment of Oral Submucous Fibrosis

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The use of plants for healing purposes has been predated long before the existence of  modern medicine. Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Study from renowned institute suggested that injection of loe vera may be reduced riak and treatment of oral submucous fibrosis.

Oral submucous fibrosis (OSMF or OSF) is a chronic condition involved oral cavity caused by inflammatory reaction and progressive fibrosis of the submucosal tissues.

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It is very popular for commercial cultivation due to its health benefits, used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc.

According to the Sibar Institute of Dental Sciences, after 3 months of Aloe Vera treatment, patients with oral submucous fibrosis (OSMF or OSF) showed a reduced levels of burning sensation and improved mouth opening.

In a total of 20 patients with oral submucous fibrosis, 10 in each group; group A subjects received 5 mg of aloe vera applied topically three times daily for 3 months and group B subjects received antioxidant capsules twice daily for 3 months study, group treated with aloe vera showed a statistically significant improvement of symptoms in comparison to control group.

Dr. Sudarshan R, the lead researcher in the study said, ". Aloe vera showed a statistically significant reduction in burning sensation (P = 0.008), improvement in mouth opening (P = 0.02), and cheek flexibility (P = 0.01) on comparing with the antioxidant group".

In support of the above differentiation, a double-blind, placebo-controlled, parallel-group randomized controlled trial conducted on 60 subjects with OSMF by Institute of Dental Sciences, Bareilly, Uttar Pradesh, insisted that group receiving aloe vera had a significant improvement in most symptoms of OSMF (P < .01) compared with the non-aloevera group,

Other researchers suggested that the analgesic effects aloe vera in reduced symptoms and treatment of oral submucous fibrosis should be accompanied with proper habit restriction together with physiotherapy exercises.

The study also emphasized the effectiveness of treatment in ameliorated symptoms, such as burning sensation,  mouth opening, tongue protrusion and cheek flexibility in comparison to other treatment groups.

Taking together, no doubt, aloe vera is effective in attenuated symptoms and treatment of patient with oral submucous fibrosis, but intake of large amount should only be prescribed by herbalist.



Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Aloe vera in the treatment for oral submucous fibrosis - a preliminary study by Sudarshan R1, Annigeri RG, Sree Vijayabala G.(PubMed)
(2) Efficacy of aloe vera gel as an adjuvant treatment of oral submucous fibrosis by Alam S1, Ali I, Giri KY, Gokkulakrishnan S, Natu SS, Faisal M, Agarwal A, Sharma H.(PubMed)
(3) Effectiveness of Aloe Vera and Antioxidant along with Physiotherapy in the Management of Oral Submucous Fibrosis by Singh N1, Hebbale M2, Mhapuskar A2, Ul Nisa S2, Thopte S2, Singh S2.(PubMed)

Thursday, 7 September 2017

Herbal Therapy: Aloe Vera, the Natural Antioxidant Whole Food

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The use of plants for healing purposes has been predated long before the existence of  modern medicine. Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Aloe Vera has shown to express to the antibacterial infection and scavenging properties with the rate of over 75% in compared to ascorbic acid (92%) a renowned institute suggested.

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorroeaceae, native to Sudan used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc. The plant is very popular for commercial cultivation due to its health benefits,

Antioxidants are the set of molecules with functions in binding the production of free radicals causes of oxidative stress to the body and fighting against the invasion of bacterial organism.

According to the Monash University Malaysia, Aloe vera bioactive compounds exerted inhibited effects against numbers of bacterial strands, particular in Bacillus (20.7%), Pseudomonas (20.7%) and Enterobacter (13.8%).

Dr. Akinsanya MA, the lead author in the joint study suggested that the efficacy of Aloe Vera is the result of the production of bioactive compounds with high DPPH, (organic chemical compound with) scavenging properties (75-88%).

In fact, in vitro, the testing various phytochemicals such as total phenolic content antioxidant activity, A. vera methanolic leaf extracts exhibited a strong antioxidant activities in free radical scavenging assay, metal chelating assay, hydrogen peroxide scavenging assay.

Although, Aloe Vera may have a significant antioxidant property but different agro-climatic conditions may effect the total phenolic content (TPC) and antioxidant potential of the plant.

The findings that Aloe Vera has exerted the antioxidant effects in various aspects, but intake of large amount should be taken with care.
 


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Diversity, antimicrobial and antioxidant activities of culturable bacterial endophyte communities in Aloe vera by Akinsanya MA1, Goh JK2, Lim SP2, Ting AS3.(PubMed)
(2) Effect of climate change on phytochemical diversity, total phenolic content and in vitro antioxidant activity of Aloe vera (L.) Burm.f by Kumar S1, Yadav A1, Yadav M1, Yadav JP2.(PubMed)

Food Therapy: Black Bean, A Potent Anti Diabetes whole Food Medicine

By Kyle J. Norton

People who turn to alternative medicine for treatment of disease in avoidance of adverse effects induced by conventional medicine should be patient. In compared to herbal medicine; food therapy even takes longer than six months to ease symptoms, depending to stage of the treatment which directly address to the cause of disease.

Black bean with abundant phytochemicals and fibers may be considered as function food in reduced risk and treatment of diabetes, a renowned university postulated.

Black bean, a small roughly ovoid legumes with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

Diabetes is a medical condition ccharacterozed by insufficient insulin entering the bloodstream to regulate the glucose. It is either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

According to the University of Illinois at Urbana-Champaign, bioactive peptides protein isolated from black bean (Phaseolus vulgaris L.) exhibited anti-diabetic activity by inhibiting important molecular markers, a particular sequence of DNA related to diabetes.

The study also stressed that certain types of peptides showed some degrees of different inhibitory potential on α-glucosidase, in compared to others. 

In C57BL/6J Mice fed a High-Fat Diet, black adzuki bean (BAB) extract exerted significantly anti diabetic effects in improved pancreatic β cells function in maintained mediation of normal glucose.

Furthermore, mice fed with dietary supplementation of black bean extract also significantly enhanced hyperglycemia and homeostasis measured by insulin resistance index, observed by expression of glucose intolerance, and regulated insulin secretion.

More importantly, in the comparison of protective effects of black bean peel extract (BBPE), pomegranate peel extract (PPE) and a combination of the two (PPE + BBPE) on streptozotocin-induced DM mice, mice treated with black bean or combination of black bean showed a strong improvement of fasting blood glucose and insulin levels, and pancreas weight index exerted through antioxidant in reduced oxidative expression.

Mice treated with PPE + BBPE also indicated a positive influence in ameliorated oxidative stress-against damage of pancreatic islets.

The finding evidences suggested that black bean, as a functional food may have a potential and therapeutic effect in prevention and treatment of diabetes.


Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Optimization of enzymatic production of anti-diabetic peptides from black bean (Phaseolus vulgaris L.) proteins, their characterization and biological potential by Mojica L1, de Mejía EG1.(PubMed)
(2) Black Adzuki Bean (Vigna angularis) Extract Protects Pancreatic β Cells and Improves Glucose Tolerance in C57BL/6J Mice Fed a High-Fat Diet by Kim M1, Kim DK2, Cha YS1.(PubMed)
(3) Extracts of black bean peel and pomegranate peel ameliorate oxidative stress-induced hyperglycemia in mice by Wang JY1, Zhu C1, Qian TW1, Guo H1, Wang DD1, Zhang F1, Yin X1.(PubMed)

Wednesday, 6 September 2017

Food Therapy: Coffee(3 to 5 Cups/ Day) Has A Maximum Effect in Reduced Risk of Cardiovascular Disease

By Kyle J. Norton

In compared to herbal medicine, food therapy even takes longer than six months to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Coffee consumers may have one less risk to worry about. A recent study by well known institute suggested that long term and moderate coffee consumption is inversely associated with CVD risk.

Coffee, becoming a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

Cardiovascular disease is a medical condition characterized by heart attack, chest pain (angina) or stroke caused by narrow blood vessels induced block blood.

In the review of literature existed from the data base involved prospective cohort studies of the relationship between coffee consumption and CVD risk, 36 satisfied the guidelines included studies, with 1 279 804 participants and 36 352 CVD cases, coffee drinkers have a nonlinear association to risk of CVD, depending to numbers of cup intake per day.

According to the joint study lead by the Harvard School of Public Health, the relative risk of cardiovascular disease in coffee consumption was .95 in compared with the 0 cup of coffee consumption per day.

Dr. Ding M, the lead author in the review said, "oderate coffee consumption was inversely significantly associated with CVD risk, with the lowest CVD risk at 3 to 5 cups per day, and heavy coffee consumption was not associated with elevated CVD risk".

In fact, long term moderate coffee consumptions not only reduced risk of heart disease, but also ameliorated other conditions associated with CV risk factors such as obesity and depression. However, the affect of caffeine in lipid file may associate to endothelial function in increased CVD risk, depending to how the coffee is prepared.

More importantly, epidemiological studies also suggest that risks of mortality in both CV and all-causes are substantially attenuated in regular coffee drinkers.

Furthermore, other researchers insisted that the health benefits of coffee consumption regarding cardiovascular system risk, mostly depend on its antioxidant compounds involved many factors, such as variety of coffee species, roasting degree, type of brewing method and serving size.

Since most of the data on coffee's health effects are based on observational data, risk of high caffeine adverse effects such as anxiety, insomnia, tremulousness, and palpitations have rarely be mentioned, therefore, more randomized, controlled studies are necessary, some researchers suggested.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Long-term coffee consumption and risk of cardiovascular disease: a systematic review and a dose-response meta-analysis of prospective cohort studies by Ding M1, Bhupathiraju SN, Satija A, van Dam RM, Hu FB.(PubMed)
(2) Effects of habitual coffee consumption on cardiometabolic disease, cardiovascular health, and all-cause mortality by O'Keefe JH1, Bhatti SK, Patil HR, DiNicolantonio JJ, Lucan SC, Lavie CJ.(PubMed)