Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia TCM Treatment - Cupping therapy

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

                        The Treatment

D. In traditional Chinese medicine perspective

2. Cupping therapy
Cupping therapy is an ancient form of alternative medicine in which a local skin suction is used to induce blood flow through median for treatment of diseases due to blood blockage. According to the Beijing University of Chinese Medicine, cupping therapy in a follow-up period of 12 weeks improved both qualitatively (patient expectation and satisfaction) and quantitatively (pain intensity, quality of life, depression assessment) in patient with Fibromyalgia when used combination with accupuncture(271) with the effective rate of 15.9% (10/63) in the group B and 16.1% (9/56) respectively in patient with or without intake of TCM medicine(272).

Furthermore, a combination of acupuncture and cupping therapy was better than conventional medications for reducing pain  and for improving depression scores with related to FM(274).

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References

(271) Using a partially randomized patient preference study design to evaluate the therapeutic effect of acupuncture and cupping therapy for fibromyalgia: study protocol for a partially randomized controlled trial by Cao HJ1, Liu JP, Hu H, Wang NS.(PubMed)

(272) [Combination of acupuncture, cupping and medicine for treatment of fibromyalgia syndrome: a multi-central randomized controlled trial].[Article in Chinese]by Jang ZY1, Li CD, Qiu L, Guo JH, He LN, Yue Y, Li FZ, Qin WY.(PubMed)

(273) Traditional Chinese Medicine for treatment of fibromyalgia: a systematic review of randomized controlled trials by Cao H1, Liu J, Lewith GT.(PubMed)

(274) Traditional Chinese Medicine for treatment of fibromyalgia: a systematic review of randomized controlled trials by Cao H1, Liu J, Lewith GT.(PubMed)

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia TCM Treatment - Acupuncture

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

                        The Treatment

D. In traditional Chinese medicine perspective
1. Acupuncture
Acupuncture in the absence of other treatment improved pain and stiffness in people with fibromyalgia according to the School of Health Sciences, RMIT University(266). Dr. Martin DP and research team at the Mayo Clinic College of Medicine said, "acupuncture significantly improved symptoms of fibromyalgia. Symptomatic improvement was not restricted to pain relief and was most significant for fatigue and anxiety"(267),  through stimulation of certain acupoint of a median, according to TCM differentiation(268).

In the review of Twenty-five RCTs with 1516 participants, traditional Chinese Medicine (TCM), ccupuncture treatment in patients with Fibromyalgia reduced the number of tender points and and pain scores compared with conventional medications(269).

Due its efficacy, acupuncture is recommended to be used for treatment in relief pain in primary care of patients with fibromyalgia in short term of 1 yea(270).

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The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet


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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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References

(266) Acupuncture for treating fibromyalgia by Deare JC1, Zheng Z, Xue CC, Liu JP, Shang J, Scott SW, Littlejohn G.(PubMed)

(267) Improvement in fibromyalgia symptoms with acupuncture: results of a randomized controlled trial by Martin DP1, Sletten CD, Williams BA, Berger IH.(PubMed)

(268) Acupoint stimulation for fibromyalgia: a systematic review of randomized controlled trials by Cao H1, Li X1, Han M1, Liu J2.(PubMed)

(269) Traditional Chinese Medicine for treatment of fibromyalgia: a systematic review of randomized controlled trials by Cao H1, Liu J, Lewith GT.(PubMed)

(270) Acupuncture for fibromyalgia in primary care: a randomised controlled trial by Vas J1, Santos-Rey K2, Navarro-Pablo R3, Modesto M2, Aguilar I2, Campos MÁ4, Aguilar-Velasco JF5, Romero M4, Párraga P5, Hervás V3, Santamaría O3,Márquez-Zurita C2, Rivas-Ruiz F6.(PubMed)

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia Other herbal medicine:Treatments

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

                        The Treatment

C. In Herbal medicine perspective
In the survey of people of a total of 11,424 adults completed the survey in 2000-2001, according to the St. Joseph's Healthcare Hamilton,, over 23% of Canadian preferred the use of natural health products for treatment of Fibromyalgia(259) particular in female population in comparison to the male counterpart.

3. Other herbal medicine: Harpagophytum procumbens (Devil’s claw), Salix alba (White willow bark), and 
Harpagophytum procumbens (Devil’s claw), Salix alba (White willow bark), according to the Systematic review of randomized controlled trials (RCTs) reduced chronic pain inpatient with lower back pain(262).

The University of Michigan study in the review of databases up to September 2014: MEDLINE, EMBASE, CENTRAL, CINAHL, Clinical Trials.gov, suggested that Harpagophytum procumbens (Devil’s claw), Salix alba (White willow bark) also reduced more pain than placbo(263).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References

(262) Herbal Medicine for Low Back Pain: A Cochrane Review by Gagnier JJ1, Oltean H, van Tulder MW, Berman BM, Bombardier C, Robbins CB.(PubMed)

(263) Herbal medicine for low-back pain by Oltean H1, Robbins C, van Tulder MW, Berman BM, Bombardier C, Gagnier JJ.(PubMed)

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia Herbal Treatment - Capsicum frutescens (Cayenne)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

                        The Treatment

C. In Herbal medicine perspective
In the survey of people of a total of 11,424 adults completed the survey in 2000-2001, according to the St. Joseph's Healthcare Hamilton,, over 23% of Canadian preferred the use of natural health products for treatment of Fibromyalgia(259) particular in female population in comparison to the male counterpart.
2. Capsicum frutescens (Cayenne)
Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions. It has been used in traditional medicine to increases metabolism, enhance circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises and neuralgia, etc.The effective of Cayenne in reduced pain in patients with fibromyalgia, probably due to its anti inflammatory activity(264).
According to the Klinik für Rheumatologie, Topically applied capsaicin (CAS 404-86-4) may be used for treatment of chronic pain through induced the release of neurotransmitter in production of substance P and blockade of transport and de-novo synthesis of substance in patients with neuropathic pain or musculoskeletal disorders, with or without inflammatory components(265).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References

(264) Final report on the safety assessment of capsicum annuum extract, capsicum annuum fruit extract, capsicumannuum resin, capsicum annuum fruit powder, capsicum frutescens fruit, capsicum frutescens fruit extract,capsicum frutescens resin, and capsaicin. by[No authors listed](PubMed)

(265) Capsicum pain plaster in chronic non-specific low back pain by Keitel W1, Frerick H, Kuhn U, Schmidt U, Kuhlmann M, Bredehorst A.(PubMed)

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia Herbal Treatment - Ginkgo biloba

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

                        The Treatment

C. In Herbal medicine perspective
In the survey of people of a total of 11,424 adults completed the survey in 2000-2001, according to the St. Joseph's Healthcare Hamilton,, over 23% of Canadian preferred the use of natural health products for treatment of Fibromyalgia(259) particular in female population in comparison to the male counterpart.
1. Ginkgo biloba
Ginkgo biloba is oldest living tree species, genus Ginkgo, belongings to the family Ginkgoaceae, native to China, from temperate zone to subtropical zone and some parts of north America. It Has been used in traditional herbal medicine in treating impotence, memory loss,respiratory diseases, circulatory disorders and deafness as well as preventing drunkenness, and bedwetting.

Dr. Lister RE said, "oral doses of 200 mg coenzyme Q10 and 200 mg Ginkgo biloba extract daily for 84 days, (showed) a progressive improvement in the quality-of-life scores was observed over the study period and at the end, the scores showed a significant difference from those at the start"(260) without interfering to the intake of warfarin(261).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References

(259) Natural health product use in Canada: analysis of the National Population Health Survey by Singh SR1, Levine MA.(PubMed)

(260) An open, pilot study to evaluate the potential benefits of coenzyme Q10 combined with Ginkgo biloba extract in fibromyalgia syndrome by Lister RE1.(PubMed)

(261) [Effect of Coenzyme Q10 and Ginkgo biloba on warfarin dosage in patients on long-term warfarin treatment. A randomized, double-blind, placebo-controlled cross-over trial].[Article in Danish]by Engelsen J1, Nielsen JD, Hansen KF.(PubMed)

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia Alternative Treatment - The Magnet therapies

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

                        The Treatment

B. Alternative treatments 
Several types of alternative medicine have some potential for future clinical research. However, due to methodological inconsistencies across studies and the small body of evidence, no firm conclusions can be made at this time. we present here some of alternatives which have played an important role in human history for treatment of Fibromyalgia, according to the DePaul University(231) and Dicle University(232), in review of information regarding the efficacy of complementary and alternative medicine (CAM).

8. Magnet therapies
Magnet therapies are the Use of magnetic fields for treatment of medical conditions in alternative medicine. According to the University of Virginia Health System, magnetic fields treatment of fibromyalgia showed improvements in functional status, pain intensity level, tender point count, and tender point intensity after 6 months(257).
Unfortunately, the average methodological quality of the identified studies was fairly low, according to the computerized search of databases from 1990 (year of publication of the ACR criteria for fibromyalgia) to July 2007 (258). A large sample size and multi center studies are necessary to validate it effect.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References

(257) Static magnetic fields for treatment of fibromyalgia: a randomized controlled trial by Alfano AP1, Taylor AG, Foresman PA, Dunkl PR, McConnell GG, Conaway MR, Gillies GT.(PubMed)

(258) Qualitative systemic review of randomized controlled trials on complementary and alternative medicine treatments in fibromyalgia by Baranowsky J1, Klose P, Musial F, Häuser W, Dobos G, Langhorst J.(PubMed)

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia Alternative Treatment - Relaxation therapy

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

                        The Treatment

B. Alternative treatments 
Several types of alternative medicine have some potential for future clinical research. However, due to methodological inconsistencies across studies and the small body of evidence, no firm conclusions can be made at this time. we present here some of alternatives which have played an important role in human history for treatment of Fibromyalgia, according to the DePaul University(231) and Dicle University(232), in review of information regarding the efficacy of complementary and alternative medicine (CAM).

8. Relaxation
Relaxation therapy, used in many cultures for reduced stress, eliminated body and mind tension for the body to heal itself against the development and for treatment of some diseases, such as Yoga, Tai Chi and meditation, etc,... According to the University Psychiatric Outpatient Clinic, relaxation therapy can be effective in treating fibromyalgia patients, especially if applied early.(255).

Dr. Coppieters I. and colleagues at the Vrije Universiteit Brussel, said," Single relaxation session as well as cognitive stress may have negative acute effects on pain modulation in patients with FM, while cognitive stress and relaxation did not worsen bottom-up sensitization in chronic WAD patients and healthy persons"(254).

In deed, Psychological interventions therapies may be effective in improving physical functioning, pain and low mood for adults with fibromyalgia but relaxation therapies remains unclear as the quality of the evidence was very low or low(256).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References

(254) Effects of Stress and Relaxation on Central Pain Modulation in Chronic Whiplash and Fibromyalgia Patients Compared to Healthy Controls by Coppieters I, Cagnie B, Nijs J1, van Oosterwijck J, Danneels L, De Pauw R, Meeus M2.(PubMed)

(255) Comparison of integrated group therapy and group relaxation training for fibromyalgia by Keel PJ1, Bodoky C, Gerhard U, Müller W.(PubMed)

(256) Mind and body therapy for fibromyalgia by Theadom A1, Cropley M, Smith HE, Feigin VL, McPherson K.(PubMed)