By Kyle J. Norton
Health article writer and researcher; Over 10.000
articles and research papers have been written and published on line,
including world wide health, ezine articles, article base, healthblogs,
selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by
Disilgold.com Named 50 of the best health Tweeters Canada - Huffington
Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as
international journal Pharma and Bio science, ISSN 0975-6299.
Polycystic Ovarian Syndrome
Polycystic Ovarian Syndrome
is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles
clumping on the ovaries that interferes with the function of the normal
ovaries associated
with a high risk for metabolic disorder(1) as resulting of enlarged
ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight
gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1
in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).
In Herbal Medicine Perspective
The prevention and management
Polycystic
ovary syndrome (PCOS) is unpreventable in Western medicine. Early
diagnosis and treatment may reduce risk of its complications, including
infertility, metabolic syndrome, obesity, diabetes, cardiovascular
diseases, stroke, etc.
Reduce fat intake less than
30% of total calories with a low
proportion of saturated fat and high in fiber from predominantly
low-glycaemic-index-carbohydrate foods for patients with PCOs(827a). Calorie intake
should be distributed between several meals
per day with restricted intake of snacks and drinks(828).
The stress management herbs
Stress
in a natural reaction of human fight or fight response induced by
pressure due to such as an environmental condition or a stimulus. Long
term stress can cause deleterious and cumulative effects on human
body(1104), including emotional or cognitive problems, such as an
increased risk of attentional deficit/hyperactivity, anxiety, and
language delay(1103), especially for people with chronic illness,
including women with Polycystic Ovarian Syndrome (PCOs)(1105).
Rhaponticum or Maral root
Rhaponticum also known as Maral root, is an herbaceous perennial plant
belongings the family Asteraceae, used in traditional Siberian, Russian
and Chinese medicine as anti-depressant(1191)(1192), anti
anxiety(1192), anti menopausal complaints(1192)(1193),
antioxidant(1194)(1195), immunomodulatory(1194)(1195),
anticancerogenic(1194)(1196)(1197),
antimicrobial(1194)(1195)(1198)(1199) and adaptogen agent(1194) and to
treat impotence(1194), enhance mental and physical
performance(1194)(1200), support the nervous(1194)(1201) and
cardiovascular system(1194)(1202)(1203), improve work capacity(1194),
etc.
Phytochemicals(1190)
1. Rosavin
2. Rosin
3. Rosarin
4. Salidroside
5. Ecdysteroids
6. Flavonoids
7. Phenolic acids
8. Polyacetylenes,
9. Sesquiterpene lactones
10. Triterpenoid glycosides
11. Terpenes
12. Etc.
According
to Russian Academy of Medical Sciences, therbal medicne also processed
anti metabolic syndrome such as serum lipid profile, corticosterone and
cytokine concentrations, glucose
tolerance, systolic blood pressure, triacylglycerol accumulation and
its induction of inflammation, stress, and hepatic steatosis in rat model(1004).
In in Wistar rats model, N-feruloylserotonins, isolated from the seeds of Leuzea carthamoides (WILLD.) DC, showed effectively in selective stress-reducing effects against stress-sensitive, such as reduced anxiety in the high-pain(1005).
In AdMax formulas, containing Leuzea
carthamoides Iljin, Rhodiola rosea L., Eleutherococcus senticosus
Maxim, and from dry berries of Schizandra chinensis Baill, improve
response to stimulus and stress, physical endurance and counteract fatigue accordiung to Genext Research, Inc.(1006)
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome:
a complex condition with psychological, reproductive and metabolic
manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1,
Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A,
Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael
C, Lambrinoudaki I.(PubMed)
(827a) Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management by Farshchi H, Rane A, Love A, Kennedy RL(PubMed)
(828) The optimal diet for women with polycystic ovary syndrome? by Marsh K, Brand-Miller J.(PubMed)
(1106) Simultaneous Estimation of Withaferin A and Z-Guggulsterone in Marketed Formulation by RP-HPLC by Agrawal P1, Vegda R2, Laddha K2.(PubMed)
(1190) Review Chemistry and pharmacology of Rhaponticum carthamoides: A review Ladislav Kokoska a,*, Dagmar Janovska(Elsevier)
(1191) [The use of a decoction of the rhizome of Leuzea carthamoides for the treatment of alcoholics with depressive states].[Article in Russian] by Ibatov AN.(PubMed)
(1192) Long-term effects of the rhapontic rhubarb extract ERr 731® on
estrogen-regulated targets in the uterus and on the bone in
ovariectomized rats by Keiler AM1, Papke A, Kretzschmar G, Zierau O, Vollmer G.(PubMed)
(1193) Treatment of menopausal symptoms by an extract from the roots of rhapontic rhubarb: the role of estrogen receptors by Vollmer G1, Papke A, Zierau O.(PubMed)
(1194) Chemistry and pharmacology of Rhaponticum carthamoides: a review by Kokoska L1, Janovska D.(PubMed)
(1195) A study on the effect of ethanol extract of Radix rhapontici on erythrocyte immune function in rats by Yan X1, Zhao H, Guan Y, Song Y, Meng J.(PubMed)
(1196) Anticarcinogenic activity of alpha-difluoromethylornithine, ginseng, eleutherococcus, and leuzea on radiation-induced carcinogenesis in female rats by Bespalov VG1, Alexandrov VA, Semenov AL, Kovan'Ko EG, Ivanov SD.(PubMed)
(1197) Subtype-specific activation of estrogen receptors by a special extract of Rheum rhaponticum (ERr 731), its aglycones and structurally related compounds in U2OS human osteosarcoma cells by Möller F1, Zierau O, Jandausch A, Rettenberger R, Kaszkin-Bettag M, Vollmer G.(PubMed)
(1198) Antimycobacterial effect of extract and its components from Rheum rhaponticum by Smolarz HD1, Swatko-Ossor M, Ginalska G, Medyńska E.(PubMed)
(1199) Investigation of the antimicrobial activity of Rhaponticum (Rhaponticum carthamoides D.C. Iljin) and shrubby cinquefoil (Potentilla fruticosa L.).[Article in English, Lithuanian] by Jurkštienė V1, Pavilonis A, Garšvienė D, Juozulynas A, Samsonienė L, Daukšienė D, Jankauskienė K, Simonienė-Kazlauskienė G, Stankevičius E.(PubMed)
(1200)
Evaluation of molecular chaperons Hsp72 and neuropeptide Y as
characteristic markers of adaptogenic activity of plant extracts by Asea
A1, Kaur P, Panossian A, Wikman KG.(PubMed)
(1201) [Cerebroprotector activity of Rhaponticum
carthamoides extract in rats with brain ischemia].[Article in Russian]
by Plotnikov MB, Logvinov SV, Pugachenko NV, Maslov MIu, Aliev OI,
Vasil'ev AS, Suslov NI, Potapov AV.(PubMed)
(1202) [Lipid peroxide, membrane fluidity of smooth muscle cells and atherosclerosis].[Article in Chinese] by Lu YC1(PubMed)
(1203) [Cardioprotective and antiarrhythmic properties of preparations from Leuzea carthamoides, Aralia mandshurica, and Eleutherococcus senticosus].[Article in Russian] by Maslov LN, Guzarova NV.(PubMed)
(1204) Effects of rhaponticum carthamoides versus glycyrrhiza glabra and punica granatum extracts on metabolic syndrome signs in rats by Dushkin M1, Khrapova M, Kovshik G, Chasovskikh M, Menshchikova E, Trufakin V, Shurlygina A, Vereschagin E.(PubMed)
(1205) The selective effect of N-feruloylserotonins isolated from Leuzea carthamoides on nociception and anxiety in rats by Yamamotová A1, Pometlová M, Harmatha J, Rasková H, Rokyta R.(PubMed)
(1206) Influence of the plant extract complex "AdMax" on global gene expression levels in cultured human fibroblast(PubMed)
Thursday, 14 May 2015
The best weightloss, weightwatching and healthy recipe: Onion salad
Posted By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Recipes contributed by Company's Coming Salads by Jean Pare
One of the best creamy good extras to serve
Granulated sugar 1/2 cup (125ml)
Water 1/3 cup (75 ml)
Vinegar 1/3 cup (75ml)
Salt 11/2 tsp. (7 ml)
Spanish onion, sliced and cut up 4
salad dressing (mayonnaise) 1 cup (250ml)
celery seed 1tsp. (5ml)
Combined sugar, vinegar and salt in bowl. Stir sugar until dissolves. Add onion to vinegar mixture. let stand for 3 hours or overnight.
Combine salad dressing with celery seed. Drain onion well. Stir into salad dressing mixture. Serve 8 to 10.
Variation. Use older vinegar instead of white.
Weight Loss the Easy Ways
Andrea Albright Featured on Health and Fitness Jan. 2015
will Personally Coach You How to Get There The Easy Way
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Recipes contributed by Company's Coming Salads by Jean Pare
One of the best creamy good extras to serve
Granulated sugar 1/2 cup (125ml)
Water 1/3 cup (75 ml)
Vinegar 1/3 cup (75ml)
Salt 11/2 tsp. (7 ml)
Spanish onion, sliced and cut up 4
salad dressing (mayonnaise) 1 cup (250ml)
celery seed 1tsp. (5ml)
Combined sugar, vinegar and salt in bowl. Stir sugar until dissolves. Add onion to vinegar mixture. let stand for 3 hours or overnight.
Combine salad dressing with celery seed. Drain onion well. Stir into salad dressing mixture. Serve 8 to 10.
Variation. Use older vinegar instead of white.
Weight Loss the Easy Ways
Andrea Albright Featured on Health and Fitness Jan. 2015
will Personally Coach You How to Get There The Easy Way
Wednesday, 13 May 2015
The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: The Stress Response and Management herbal Licorice
By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Polycystic Ovarian Syndrome
Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).
In Herbal Medicine Perspective
The prevention and management
Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.
Reduce fat intake less than 30% of total calories with a low proportion of saturated fat and high in fiber from predominantly low-glycaemic-index-carbohydrate foods for patients with PCOs(827a). Calorie intake should be distributed between several meals per day with restricted intake of snacks and drinks(828).
The stress management herbs
Stress in a natural reaction of human fight or fight response induced by pressure due to such as an environmental condition or a stimulus. Long term stress can cause deleterious and cumulative effects on human body(1104), including emotional or cognitive problems, such as an increased risk of attentional deficit/hyperactivity, anxiety, and language delay(1103), especially for people with chronic illness, including women with Polycystic Ovarian Syndrome (PCOs)(1105).
Licorice
(See herbal treatment of PCOs for more information)
[Gan Cao is also known as Licorice root. The sweet and neutral herb has been used in TCM as anti allergy(856), anti inflammation(855), anti ulcer(857), anti convulsion(858) agent and to treat stomach weakness, tired and lack of strength, cough with abundance of phlegm, stomach and solar plexus pain, and improve cardiac function(855), etc., as it tonifies the Spleen, benefits the Qi, moistens the Lungs, calms cough, deaf or acute pain, by enhancing all 12 channels(859).
In treatment of PCOs(862), combination of licorice and 100 mg spironolactone showed the activation of the renin-aldosterone system in lowering blood pressure and water (fluid) balance(860). reducing the prevalence of side effects related to the diuretic activity of spironolactone(860). In model rats experiment, Ganshao Paste (CGP), showed the decrease of serum levels of LH, T, and FSH and increase of serum estradiol (E2), and progesterone (P)(861)(865)].
(See The Insulin resistance improvement and/or anti metabolic syndrome herbs: Licorice for more information)
1. PCOs
In chronic unpredictable stress rat model, total flavonoids extract(1153) (licorice flavonoids, LF) and liquiritin(1154), a phyochemical found in locorice exerted anti-depressive(1153)(1154)(1155) and anti-cognitive impairment(1156) property through total flavonoids extract neurogenesis protective effect(1153) and defense of liquiritin and flavonoids extract against oxidative stress(1154)(1156).
Yokukansan, a traditional Japanese formula, containing licorice showed effectively in amelioration of behavioral symptoms, such as aggressiveness, excitability, and hallucination, through reduced stress increased the serotonin 2A (5-HT2A) receptors density on the plasma membrane of the prefrontal cortex (PFC)(1158).
In high-glucose stress, Glabridin(1159)(1160), an isoflavan from licorice root reduced high-glucose stress(1159)(1160) through its anti inflammatory activity(1159), up-regulates manganese superoxide dismutase, catalase and paraoxonase 2(1160).
In anti oxidative stress, licorice showed to contribute to their overall health promoting pharmacological effects against free radicals(1161)(1162)(1163)(1164) induced diseases such as cancer(1161), cardiac dysfunction(1162) liver diosease(1164), etc., through its anti-inflammatory(1161)(1163)(1164), anti-oxidant activities(1161)(1162)(1163)(1164).
According to University of Western Sydney, Glycyrrhiza glabra, one of Chinese herbs, exhibited strong evidences of neuroprotective activity for promotion of healthy ageing and longevity(1157).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(827a) Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management by Farshchi H, Rane A, Love A, Kennedy RL(PubMed)
(828) The optimal diet for women with polycystic ovary syndrome? by Marsh K, Brand-Miller J.(PubMed) (1106) Simultaneous Estimation of Withaferin A and Z-Guggulsterone in Marketed Formulation by RP-HPLC by Agrawal P1, Vegda R2, Laddha K2.(PubMed)
(1153) [Antidepressant activities of flavonoids from Glycyrrhiza uralensis and its neurogenesis protective effect in rats].[Article in Chinese] by Fan ZZ1, Zhao WH, Guo J, Cheng RF, Zhao JY, Yang WD, Wang YH, Li W, Peng XD.(PubMed)
(1154) Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats by Zhao Z1, Wang W, Guo H, Zhou D.(PubMed)
(1155) Metabonomic study on chronic unpredictable mild stress and intervention effects of Xiaoyaosan in rats using gas chromatography coupled with mass spectrometry by Gao X1, Zheng X, Li Z, Zhou Y, Sun H, Zhang L, Guo X, Du G, Qin X.(PubMed)
(1156) Neuroprotective effects of flavonoids extracted from licorice on kainate-induced seizure in mice through their antioxidant properties by Zeng LH1, Zhang HD, Xu CJ, Bian YJ, Xu XJ, Xie QM, Zhang RH.(PubMed)
(1157) An in vitro study of neuroprotective properties of traditional Chinese herbal medicines thought to promote healthy ageing and longevity by Shen B, Truong J, Helliwell R, Govindaraghavan S, Sucher NJ1.(PubMed)
(1158) Yokukansan, a traditional Japanese medicine, decreases head-twitch behaviors and serotonin 2A receptors in the prefrontal cortex of isolation-stressed mice, by Ueki T1, Mizoguchi K2, Yamaguchi T2, Nishi A2, Sekiguchi K2, Ikarashi Y2, Kase Y2.(PubMed)
(1159) Glabridin, an isoflavan from licorice root, downregulates iNOS expression and activity under high-glucose stress and inflammation by Yehuda I1, Madar Z, Leikin-Frenkel A, Tamir S.(PubMed)
(1160) Glabridin, a phytoestrogen from licorice root, up-regulates manganese superoxide dismutase, catalase and paraoxonase 2 under glucose stress by Yehuda I1, Madar Z, Szuchman-Sapir A, Tamir S.(PubMed)
(1161) Anti-inflammatory/Anti-oxidative stress activities and differential regulation of Nrf2-mediated genes by non-polar fractions of tea Chrysanthemum zawadskii and licorice Glycyrrhiza uralensis by Wu TY1, Khor TO, Saw CL, Loh SC, Chen AI, Lim SS, Park JH, Cai L, Kong AN.(PubMed)
(1162) Licorice treatment prevents oxidative stress, restores cardiac function, and salvages myocardium in rat model of myocardial injury by Ojha SK1, Sharma C1, Golechha MJ1, Bhatia J1, Kumari S2, Arya DS3.(PubMed)
(1163) Licochalcone A activates Nrf2 in vitro and contributes to licorice extract-induced lowered cutaneous oxidative stress in vivo by Kühnl J1, Roggenkamp D, Gehrke SA, Stäb F, Wenck H, Kolbe L, Neufang G.(PubMed)
(1164) 18-β Glycyrrhetinic acid alleviates 2-acetylaminofluorene-induced hepatotoxicity in Wistar rats: Role in hyperproliferation, inflammation and oxidative stress by Hasan S1, Khan R1, Ali N1, Khan A1, Rehman M1, Tahir M1, Lateef A1, Nafees S1, Mehdi S1, Rashid S1, Shahid A1, Sultana S2.(PubMed)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Polycystic Ovarian Syndrome
Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).
In Herbal Medicine Perspective
The prevention and management
Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.
Reduce fat intake less than 30% of total calories with a low proportion of saturated fat and high in fiber from predominantly low-glycaemic-index-carbohydrate foods for patients with PCOs(827a). Calorie intake should be distributed between several meals per day with restricted intake of snacks and drinks(828).
The stress management herbs
Stress in a natural reaction of human fight or fight response induced by pressure due to such as an environmental condition or a stimulus. Long term stress can cause deleterious and cumulative effects on human body(1104), including emotional or cognitive problems, such as an increased risk of attentional deficit/hyperactivity, anxiety, and language delay(1103), especially for people with chronic illness, including women with Polycystic Ovarian Syndrome (PCOs)(1105).
Licorice
(See herbal treatment of PCOs for more information)
[Gan Cao is also known as Licorice root. The sweet and neutral herb has been used in TCM as anti allergy(856), anti inflammation(855), anti ulcer(857), anti convulsion(858) agent and to treat stomach weakness, tired and lack of strength, cough with abundance of phlegm, stomach and solar plexus pain, and improve cardiac function(855), etc., as it tonifies the Spleen, benefits the Qi, moistens the Lungs, calms cough, deaf or acute pain, by enhancing all 12 channels(859).
In treatment of PCOs(862), combination of licorice and 100 mg spironolactone showed the activation of the renin-aldosterone system in lowering blood pressure and water (fluid) balance(860). reducing the prevalence of side effects related to the diuretic activity of spironolactone(860). In model rats experiment, Ganshao Paste (CGP), showed the decrease of serum levels of LH, T, and FSH and increase of serum estradiol (E2), and progesterone (P)(861)(865)].
(See The Insulin resistance improvement and/or anti metabolic syndrome herbs: Licorice for more information)
1. PCOs
[ Licorice, in a review of 33 studies of herbal medicine for the management of polycystic ovary syndrome
(PCOS), showed a stronge evidences in improved metabolic hormone
profile and improved fertility outcomes and regulation of ovulation and
inhibition of hyperandrogenism in PCOS(860). In model rats
experiment, Ganshao Paste (CGP), also decreased serum levels of
LH, T, and FSH and increased of serum estradiol (E2), and progesterone
(P)(861)(860)(865). According to University
of Natural Resources and Life Sciences Vienna, licorice may have a
potential effect on metabolic syndrome(862) in women with PCOs.
2. Blow flow
Licorice improves the blood flow in the body by exerting its anti thrombosis(983) and inhibiting the levels of bad cholesterol(984)(985) and triglyceride levels(985) and increasing HDL-cholesterol content(984) in reduced risk of cardiovascular disease(985) and blood stagnation(897) in the abdominal region induced induced infertility(986).
3. Glycyrrhizin
Glycyrrhizin, one of main ingredient from licorice, exhibited anti inflammatory effect pharmacologically in treatment of inflammatory diseases(988)(989)(990), lowered high serum testosterone levels in oligomenorrheic or amenorrheic women, and induced conception in some women(991). As antioxidant, the phytochemical also inhibit irregular cell growth(992)(993) and microbial invasion(994)(995) causes of cancers(992)(993) and infection and inflammation(994)(995) respectively. in adrenocortical function and behavour, it also regulated the levels of cortisol(996), induced by over production of serotonin cause of hormone imbalance(997).
4. Phytoestrogen
2. Blow flow
Licorice improves the blood flow in the body by exerting its anti thrombosis(983) and inhibiting the levels of bad cholesterol(984)(985) and triglyceride levels(985) and increasing HDL-cholesterol content(984) in reduced risk of cardiovascular disease(985) and blood stagnation(897) in the abdominal region induced induced infertility(986).
3. Glycyrrhizin
Glycyrrhizin, one of main ingredient from licorice, exhibited anti inflammatory effect pharmacologically in treatment of inflammatory diseases(988)(989)(990), lowered high serum testosterone levels in oligomenorrheic or amenorrheic women, and induced conception in some women(991). As antioxidant, the phytochemical also inhibit irregular cell growth(992)(993) and microbial invasion(994)(995) causes of cancers(992)(993) and infection and inflammation(994)(995) respectively. in adrenocortical function and behavour, it also regulated the levels of cortisol(996), induced by over production of serotonin cause of hormone imbalance(997).
4. Phytoestrogen
See phytoestrogen in black cohosh
[Phytoestrogen found it balck cohosh showed to occupy the estrogen receptor sites in women body(908), through it antiestrogenic and extrogenic effects(909), to induce hormone balancing may result in improving the chance of ovulation and fertility(910)(911)].
5. Lecithin
Lecithin is a fat like substance called a phospholipid improved lipid transfer, cholesterol efflux, HDL genesis and and remodeling at the blood-brain barrier (BBB)(998). against cells from oxidation surrounding the brain(999), in reducing psychotic symptoms(1002) such as stress(1000)(1001), and depression(1002).
[Phytoestrogen found it balck cohosh showed to occupy the estrogen receptor sites in women body(908), through it antiestrogenic and extrogenic effects(909), to induce hormone balancing may result in improving the chance of ovulation and fertility(910)(911)].
5. Lecithin
Lecithin is a fat like substance called a phospholipid improved lipid transfer, cholesterol efflux, HDL genesis and and remodeling at the blood-brain barrier (BBB)(998). against cells from oxidation surrounding the brain(999), in reducing psychotic symptoms(1002) such as stress(1000)(1001), and depression(1002).
Side effects
1. It may raise blood pressure(1003)(1004(1006)
2. Long term usage of large dosage can also cause edema(1004)(1006) and hypokalemia(1004)(1005)(1006).
3. Overdose can be toxic(106), in inducing rhabdomyolysis or myoglobinuria(1006).
4. Etc.]
1. It may raise blood pressure(1003)(1004(1006)
2. Long term usage of large dosage can also cause edema(1004)(1006) and hypokalemia(1004)(1005)(1006).
3. Overdose can be toxic(106), in inducing rhabdomyolysis or myoglobinuria(1006).
4. Etc.]
Phytochemicals(1058)
1. Glycyrrhizic acid
2. Licochalcone A
3. Licochalcone B
4. Licoflavone
5. Liquiritin
5. Liquiritigenin
7. Isoliquiritigenin
8. Ononins
9. 4′，7-dihydroxyflavone
10. Glycyrrhetinic acid
11. 11-deoxyglycyrrhetinic acid
12. β-sitosterol
13. Etc.
Licorice's phytochemicals, especially glycyrrhizin, have shown efffectively in ameliorated insulin resistance(1059)(1061)(1063)(1064),
hyperglycemia(1059)(1060), dyslipidemia(1059)(1063) and oxidative
stress(1064) in fructose-induced metabolic syndrome(1059)(1061)(1063) in
animal(1059)(1060)(1061)models, probably through its interference of
the development of visceral obesity(1064) and cellular derailments that
are responsible for the development of metabolic syndrome(1062), anti
inflammatory(1062), antioxidant(1062) and an associated with a decrease
in tissue lipid deposition(1063) effects].In chronic unpredictable stress rat model, total flavonoids extract(1153) (licorice flavonoids, LF) and liquiritin(1154), a phyochemical found in locorice exerted anti-depressive(1153)(1154)(1155) and anti-cognitive impairment(1156) property through total flavonoids extract neurogenesis protective effect(1153) and defense of liquiritin and flavonoids extract against oxidative stress(1154)(1156).
Yokukansan, a traditional Japanese formula, containing licorice showed effectively in amelioration of behavioral symptoms, such as aggressiveness, excitability, and hallucination, through reduced stress increased the serotonin 2A (5-HT2A) receptors density on the plasma membrane of the prefrontal cortex (PFC)(1158).
In high-glucose stress, Glabridin(1159)(1160), an isoflavan from licorice root reduced high-glucose stress(1159)(1160) through its anti inflammatory activity(1159), up-regulates manganese superoxide dismutase, catalase and paraoxonase 2(1160).
In anti oxidative stress, licorice showed to contribute to their overall health promoting pharmacological effects against free radicals(1161)(1162)(1163)(1164) induced diseases such as cancer(1161), cardiac dysfunction(1162) liver diosease(1164), etc., through its anti-inflammatory(1161)(1163)(1164), anti-oxidant activities(1161)(1162)(1163)(1164).
According to University of Western Sydney, Glycyrrhiza glabra, one of Chinese herbs, exhibited strong evidences of neuroprotective activity for promotion of healthy ageing and longevity(1157).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(827a) Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management by Farshchi H, Rane A, Love A, Kennedy RL(PubMed)
(828) The optimal diet for women with polycystic ovary syndrome? by Marsh K, Brand-Miller J.(PubMed) (1106) Simultaneous Estimation of Withaferin A and Z-Guggulsterone in Marketed Formulation by RP-HPLC by Agrawal P1, Vegda R2, Laddha K2.(PubMed)
(1153) [Antidepressant activities of flavonoids from Glycyrrhiza uralensis and its neurogenesis protective effect in rats].[Article in Chinese] by Fan ZZ1, Zhao WH, Guo J, Cheng RF, Zhao JY, Yang WD, Wang YH, Li W, Peng XD.(PubMed)
(1154) Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats by Zhao Z1, Wang W, Guo H, Zhou D.(PubMed)
(1155) Metabonomic study on chronic unpredictable mild stress and intervention effects of Xiaoyaosan in rats using gas chromatography coupled with mass spectrometry by Gao X1, Zheng X, Li Z, Zhou Y, Sun H, Zhang L, Guo X, Du G, Qin X.(PubMed)
(1156) Neuroprotective effects of flavonoids extracted from licorice on kainate-induced seizure in mice through their antioxidant properties by Zeng LH1, Zhang HD, Xu CJ, Bian YJ, Xu XJ, Xie QM, Zhang RH.(PubMed)
(1157) An in vitro study of neuroprotective properties of traditional Chinese herbal medicines thought to promote healthy ageing and longevity by Shen B, Truong J, Helliwell R, Govindaraghavan S, Sucher NJ1.(PubMed)
(1158) Yokukansan, a traditional Japanese medicine, decreases head-twitch behaviors and serotonin 2A receptors in the prefrontal cortex of isolation-stressed mice, by Ueki T1, Mizoguchi K2, Yamaguchi T2, Nishi A2, Sekiguchi K2, Ikarashi Y2, Kase Y2.(PubMed)
(1159) Glabridin, an isoflavan from licorice root, downregulates iNOS expression and activity under high-glucose stress and inflammation by Yehuda I1, Madar Z, Leikin-Frenkel A, Tamir S.(PubMed)
(1160) Glabridin, a phytoestrogen from licorice root, up-regulates manganese superoxide dismutase, catalase and paraoxonase 2 under glucose stress by Yehuda I1, Madar Z, Szuchman-Sapir A, Tamir S.(PubMed)
(1161) Anti-inflammatory/Anti-oxidative stress activities and differential regulation of Nrf2-mediated genes by non-polar fractions of tea Chrysanthemum zawadskii and licorice Glycyrrhiza uralensis by Wu TY1, Khor TO, Saw CL, Loh SC, Chen AI, Lim SS, Park JH, Cai L, Kong AN.(PubMed)
(1162) Licorice treatment prevents oxidative stress, restores cardiac function, and salvages myocardium in rat model of myocardial injury by Ojha SK1, Sharma C1, Golechha MJ1, Bhatia J1, Kumari S2, Arya DS3.(PubMed)
(1163) Licochalcone A activates Nrf2 in vitro and contributes to licorice extract-induced lowered cutaneous oxidative stress in vivo by Kühnl J1, Roggenkamp D, Gehrke SA, Stäb F, Wenck H, Kolbe L, Neufang G.(PubMed)
(1164) 18-β Glycyrrhetinic acid alleviates 2-acetylaminofluorene-induced hepatotoxicity in Wistar rats: Role in hyperproliferation, inflammation and oxidative stress by Hasan S1, Khan R1, Ali N1, Khan A1, Rehman M1, Tahir M1, Lateef A1, Nafees S1, Mehdi S1, Rashid S1, Shahid A1, Sultana S2.(PubMed)
The best weightloss, weightwatching and healthy recipe: Penny carrots
Posted By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Recipes contributed by Company's Coming Salads by Jean Pare
So versatile, this can be served cold as a salad or relish and also reserve hot. Try it hot over rice.
Carrots, sliced 1/2 inch (12mm) thick, cooked and drained 2 lbs. (1 kg)
Condensed tomato soup 10oz. (284ml)
Granulate sugar 1 cup (250ml)
Vinegar 3/4 cup (175ml)
Cooking oil 1/4 cup (50ml)
Prepared mustard 1tbsp. (15ml)
Medium onion, chopped 1
Green peppers, chopped 2
Combined soup with sugar in medium size saucepan. Add vinegar, oil, mustard, chopped onion and chopped peppers. bring to a boil, stirring frequently. pour over carrots. Chilled covered for 2 days. Serve 12.
Weight Loss the Easy Ways
Andrea Albright Featured on Health and Fitness Jan. 2015
will Personally Coach You How to Get There The Easy Way
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Recipes contributed by Company's Coming Salads by Jean Pare
So versatile, this can be served cold as a salad or relish and also reserve hot. Try it hot over rice.
Carrots, sliced 1/2 inch (12mm) thick, cooked and drained 2 lbs. (1 kg)
Condensed tomato soup 10oz. (284ml)
Granulate sugar 1 cup (250ml)
Vinegar 3/4 cup (175ml)
Cooking oil 1/4 cup (50ml)
Prepared mustard 1tbsp. (15ml)
Medium onion, chopped 1
Green peppers, chopped 2
Combined soup with sugar in medium size saucepan. Add vinegar, oil, mustard, chopped onion and chopped peppers. bring to a boil, stirring frequently. pour over carrots. Chilled covered for 2 days. Serve 12.
Weight Loss the Easy Ways
Andrea Albright Featured on Health and Fitness Jan. 2015
will Personally Coach You How to Get There The Easy Way
Tuesday, 12 May 2015
The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: The Stress Response and Management herbal Ginseng
By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Polycystic Ovarian Syndrome
Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).
In Herbal Medicine Perspective
The prevention and management
Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.
Reduce fat intake less than 30% of total calories with a low proportion of saturated fat and high in fiber from predominantly low-glycaemic-index-carbohydrate foods for patients with PCOs(827a). Calorie intake should be distributed between several meals per day with restricted intake of snacks and drinks(828).
The stress management herbs
Stress in a natural reaction of human fight or fight response induced by pressure due to such as an environmental condition or a stimulus. Long term stress can cause deleterious and cumulative effects on human body(1104), including emotional or cognitive problems, such as an increased risk of attentional deficit/hyperactivity, anxiety, and language delay(1103), especially for people with chronic illness, including women with Polycystic Ovarian Syndrome (PCOs)(1105).
Ginseng (Panax spp.)
(See Herbal treatment for PCOs for more information)
[ Ginseng Asia is also known as Panax ginseng. Since it has been grown in the cold places in the Asian, Asian ginseng is considered as yang promoting, according to traditional Chinese medicine.
Korean red ginseng extract (KRGE) in the experiment in PCOs induced rodent, improved PCO-related ovarian dysfunction(830). In rat model, induced by injection of estradiol valerate (EV), the extract also regulated sympathetic nerve activity by significantly lower expression of NGF protein (involved in the growth of peripheral nerve cells) and NGF mRNA(the form of RNA that carries information from DNA) involved in the abnormal process caused by steroid-induced PCO(830). Also, in the experiment of Ginseng total saponins (GTS) involved polycystic ovaries induced by a single intramuscular injection of 4 mg estradiol valerate (EV) in rats, GTS decreased the expression of NGF in ovary tissue(831)].
(See herbal medicine for weight loss)
[Ginseng is a slow-growing perennial plants with fleshy roots, the genus Panax, belonging to the family Araliaceae. Depending to the climate where it grows, ginseng can be classified mainly into Panax ginseng Asian ginseng (root), Red ginseng, wild ginseng, American ginseng (root)(791).
In 10 obese middle-aged Korean women who took Panax ginseng extracts for 8 wk, showed effectively in influence on gut microbiota in promoting weigh loss but depending to the composition of gut microbiota prior to ginseng intake(792). In mice fed on a high-fat diet, ginseng saponin and ginsenosides not only exerted anti-obesity effects via the modulation of physiological lipid metabolism in vivo or intracellular signalling in cell culture systems, but also promoted anti-obesity effects, through abnormal physiology via HFD. Leptin, insulin, and adiponectin, which carry out critical functions in energy and lipid metabolism(793)].
The Phytochemicals
1. Ginsenoside
2. Notoginsenoside
3. Chikusetsuaponin IV
4. Panaxynol
5. Ginsenyne
6. Alpha pansinsene
7. Beta pansinsene
8. Beta farnesene
9. Bicyclogermacrene
10. Beta elemene
11. Gama elemene
12. Alpha neodovene
13. Beta neodovene
14. Alpha humulene
15. Beta humulene
16. Caryophyllene
17. Beta gurjunene
18. Alpha gurjunene
19. Citric acid
20. Isocitric acid
21. Fumaric acid
22. Oleic acid,
23. Linoleic acid
24. Beta sitosterol
25. Stigmasterol
26. Daucosterol
27. Sitosteryl-o-(6-O-fatty acyl)-glucpyranoside
28. Etc.
Panax ginseng, native to Korea, one of most frequent and wonderful used over thousand years in herbal medicine for improvement of male over all health due to aging diminished steroidal hormone in Asian(1138) has found to process significant anti-stress (1137)(1143)(1144), such as adapt to stress(1138) through reverted cholesterol (CL), creatine kinase (CK) activity(1137) anti oxidative stress(1139)(1142)(1146) through its elevation in catalase (CAT), and superoxide dismutase (SOD) activities as scavenger enzymes(1139). antioxidant effects(1140).
In immobilized mice, orally administered ginsenoside Rb1 found in Panax ginseng exhibited its anti stress effects through regulation of serum levels of corticosterone(1145) and interleukin (IL)-6(1141).
In chronic unpredictable mild stress rat model, ginsenosides also ameliorated stress symptoms of depression(1147)(1149)(1150) through significantly suppressed behavioral and biochemical changes(1147) and cognitive impairment, neuroinflammation, and biochemical alterations through improved corticosterone levels; and attenuated oxidative-nitrergic stress(1148).
In stress induced metabolic syndrome(1151), ginseng' saponins (ginsenosides) are proven effectively for its properties of anti-hyperglycemia, insulin sensitization, islet protection, anti-obesity and anti-oxidation in many model systems, according to Louisana State University System(1152).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(827a) Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management by Farshchi H, Rane A, Love A, Kennedy RL(PubMed)
(828) The optimal diet for women with polycystic ovary syndrome? by Marsh K, Brand-Miller J.(PubMed) (1106) Simultaneous Estimation of Withaferin A and Z-Guggulsterone in Marketed Formulation by RP-HPLC by Agrawal P1, Vegda R2, Laddha K2.(PubMed)
(1103) Antenatal maternal stress and long-term effects on child neurodevelopment: how and why? by Talge NM1, Neal C, Glover V; Early Stress, Translational Research and Prevention Science Network: Fetal and Neonatal Experience on Child and Adolescent Mental Health.(PubMed)
(1104) Immediate and long-term effects of meditation on acute stress reactivity, cognitive functions, and intelligence by Singh Y1, Sharma R, Talwar A.(PubMed)
(1105) The potential implications of a PCOS diagnosis on a woman's long-term health using data linkage by Hart R1, Doherty DA.(PubMed)
(1137) Anti-stress effects of Ginkgo biloba and Panax ginseng: a comparative study by Rai D1, Bhatia G, Sen T, Palit G.(PubMed)
(1138) Ginseng, Korean(The free dictionary by Farlet)
(1139) Effects of Panax ginseng extract on exercise-induced oxidative stress by Kim SH1, Park KS, Chang MJ, Sung JH.(PubMed)
(1140) Saponins from Panax japonicus attenuate D-galactose-induced cognitive impairment through its anti-oxidative and anti-apoptotic effects in rats by Wang T1, Di G, Yang L, Dun Y, Sun Z, Wan J, Peng B, Liu C, Xiong G, Zhang C, Yuan D. (PubMed)
(1141) Anti-stress effects of 20(S)-protopanaxadiol and 20(S)-protopanaxatriol in immobilized mice by Oh HA1, Kim DE, Choi HJ, Kim NJ, Kim DH.(PubMed)
(1142) Protective effect of panax notoginseng saponins on acute ethanol-induced liver injury is associated with ameliorating hepatic lipid accumulation and reducing ethanol-mediated oxidative stress by Ding RB1, Tian K, Cao YW, Bao JL, Wang M, He C, Hu Y, Su H, Wan JB.(PubMed)
(1143) [The anti-stress effect of saponins extracted from panax ginseng fruit and the hypophyseal-adrenal system (author's transl)].[Article in Chinese] by Zhang SC, Jiang XL.(PubMed)
(1144) Ginseng and the hypothalamic-pituitary control of stress by Fulder SJ.(PubMed)
(1145) Stimulation of pituitary-adrenocortical system by ginseng saponin by Hiai S, Yokoyama H, Oura H, Yano S.(PubMed)
(1146) [Study on the mechanism of action of total saponins of Panax notoginseng in ameliorating oxidative stress and insulin resistance in rats fed with high fat diet].[Article in Chinese] by Zhang SS1, Wu ZY2, Chen JM3, Guo QK2, Li L2, Wang ZF2, Gao Y4, Ma ZC4.(PubMed)
(1147) [Effects of ginsenosides on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factor in rats exposed to chronic unpredictable mild stress].[Article in Chinese] by Liu L1, Luo Y, Zhang R, Guo J.(PubMed)
(1148) Modulation of nitrergic signalling pathway by American ginseng attenuates chronic unpredictable stress-induced cognitive impairment, neuroinflammation, and biochemical alterations by Rinwa P1, Kumar A.(PubMed)
(1149) Ginsenoside Rb3 exerts antidepressant-like effects in several animal models by Cui J1, Jiang L, Xiang H.(PubMed)
(1150) Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression by Dang H1, Chen Y, Liu X, Wang Q, Wang L, Jia W, Wang Y.(PubMed)
(1151) Role of Endoplasmic Reticulum Stress in Metabolic Disease and Other Disorders by Lale Ozcan and Ira Tabas(PubMed)
(1152) Traditional chinese medicine in treatment of metabolic syndrome by Yin J1, Zhang H, Ye J.(PubMed)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Polycystic Ovarian Syndrome
Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).
In Herbal Medicine Perspective
The prevention and management
Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.
Reduce fat intake less than 30% of total calories with a low proportion of saturated fat and high in fiber from predominantly low-glycaemic-index-carbohydrate foods for patients with PCOs(827a). Calorie intake should be distributed between several meals per day with restricted intake of snacks and drinks(828).
The stress management herbs
Stress in a natural reaction of human fight or fight response induced by pressure due to such as an environmental condition or a stimulus. Long term stress can cause deleterious and cumulative effects on human body(1104), including emotional or cognitive problems, such as an increased risk of attentional deficit/hyperactivity, anxiety, and language delay(1103), especially for people with chronic illness, including women with Polycystic Ovarian Syndrome (PCOs)(1105).
Ginseng (Panax spp.)
(See Herbal treatment for PCOs for more information)
[ Ginseng Asia is also known as Panax ginseng. Since it has been grown in the cold places in the Asian, Asian ginseng is considered as yang promoting, according to traditional Chinese medicine.
Korean red ginseng extract (KRGE) in the experiment in PCOs induced rodent, improved PCO-related ovarian dysfunction(830). In rat model, induced by injection of estradiol valerate (EV), the extract also regulated sympathetic nerve activity by significantly lower expression of NGF protein (involved in the growth of peripheral nerve cells) and NGF mRNA(the form of RNA that carries information from DNA) involved in the abnormal process caused by steroid-induced PCO(830). Also, in the experiment of Ginseng total saponins (GTS) involved polycystic ovaries induced by a single intramuscular injection of 4 mg estradiol valerate (EV) in rats, GTS decreased the expression of NGF in ovary tissue(831)].
(See herbal medicine for weight loss)
[Ginseng is a slow-growing perennial plants with fleshy roots, the genus Panax, belonging to the family Araliaceae. Depending to the climate where it grows, ginseng can be classified mainly into Panax ginseng Asian ginseng (root), Red ginseng, wild ginseng, American ginseng (root)(791).
In 10 obese middle-aged Korean women who took Panax ginseng extracts for 8 wk, showed effectively in influence on gut microbiota in promoting weigh loss but depending to the composition of gut microbiota prior to ginseng intake(792). In mice fed on a high-fat diet, ginseng saponin and ginsenosides not only exerted anti-obesity effects via the modulation of physiological lipid metabolism in vivo or intracellular signalling in cell culture systems, but also promoted anti-obesity effects, through abnormal physiology via HFD. Leptin, insulin, and adiponectin, which carry out critical functions in energy and lipid metabolism(793)].
The Phytochemicals
1. Ginsenoside
2. Notoginsenoside
3. Chikusetsuaponin IV
4. Panaxynol
5. Ginsenyne
6. Alpha pansinsene
7. Beta pansinsene
8. Beta farnesene
9. Bicyclogermacrene
10. Beta elemene
11. Gama elemene
12. Alpha neodovene
13. Beta neodovene
14. Alpha humulene
15. Beta humulene
16. Caryophyllene
17. Beta gurjunene
18. Alpha gurjunene
19. Citric acid
20. Isocitric acid
21. Fumaric acid
22. Oleic acid,
23. Linoleic acid
24. Beta sitosterol
25. Stigmasterol
26. Daucosterol
27. Sitosteryl-o-(6-O-fatty acyl)-glucpyranoside
28. Etc.
Panax ginseng, native to Korea, one of most frequent and wonderful used over thousand years in herbal medicine for improvement of male over all health due to aging diminished steroidal hormone in Asian(1138) has found to process significant anti-stress (1137)(1143)(1144), such as adapt to stress(1138) through reverted cholesterol (CL), creatine kinase (CK) activity(1137) anti oxidative stress(1139)(1142)(1146) through its elevation in catalase (CAT), and superoxide dismutase (SOD) activities as scavenger enzymes(1139). antioxidant effects(1140).
In immobilized mice, orally administered ginsenoside Rb1 found in Panax ginseng exhibited its anti stress effects through regulation of serum levels of corticosterone(1145) and interleukin (IL)-6(1141).
In chronic unpredictable mild stress rat model, ginsenosides also ameliorated stress symptoms of depression(1147)(1149)(1150) through significantly suppressed behavioral and biochemical changes(1147) and cognitive impairment, neuroinflammation, and biochemical alterations through improved corticosterone levels; and attenuated oxidative-nitrergic stress(1148).
In stress induced metabolic syndrome(1151), ginseng' saponins (ginsenosides) are proven effectively for its properties of anti-hyperglycemia, insulin sensitization, islet protection, anti-obesity and anti-oxidation in many model systems, according to Louisana State University System(1152).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(827a) Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management by Farshchi H, Rane A, Love A, Kennedy RL(PubMed)
(828) The optimal diet for women with polycystic ovary syndrome? by Marsh K, Brand-Miller J.(PubMed) (1106) Simultaneous Estimation of Withaferin A and Z-Guggulsterone in Marketed Formulation by RP-HPLC by Agrawal P1, Vegda R2, Laddha K2.(PubMed)
(1103) Antenatal maternal stress and long-term effects on child neurodevelopment: how and why? by Talge NM1, Neal C, Glover V; Early Stress, Translational Research and Prevention Science Network: Fetal and Neonatal Experience on Child and Adolescent Mental Health.(PubMed)
(1104) Immediate and long-term effects of meditation on acute stress reactivity, cognitive functions, and intelligence by Singh Y1, Sharma R, Talwar A.(PubMed)
(1105) The potential implications of a PCOS diagnosis on a woman's long-term health using data linkage by Hart R1, Doherty DA.(PubMed)
(1137) Anti-stress effects of Ginkgo biloba and Panax ginseng: a comparative study by Rai D1, Bhatia G, Sen T, Palit G.(PubMed)
(1138) Ginseng, Korean(The free dictionary by Farlet)
(1139) Effects of Panax ginseng extract on exercise-induced oxidative stress by Kim SH1, Park KS, Chang MJ, Sung JH.(PubMed)
(1140) Saponins from Panax japonicus attenuate D-galactose-induced cognitive impairment through its anti-oxidative and anti-apoptotic effects in rats by Wang T1, Di G, Yang L, Dun Y, Sun Z, Wan J, Peng B, Liu C, Xiong G, Zhang C, Yuan D. (PubMed)
(1141) Anti-stress effects of 20(S)-protopanaxadiol and 20(S)-protopanaxatriol in immobilized mice by Oh HA1, Kim DE, Choi HJ, Kim NJ, Kim DH.(PubMed)
(1142) Protective effect of panax notoginseng saponins on acute ethanol-induced liver injury is associated with ameliorating hepatic lipid accumulation and reducing ethanol-mediated oxidative stress by Ding RB1, Tian K, Cao YW, Bao JL, Wang M, He C, Hu Y, Su H, Wan JB.(PubMed)
(1143) [The anti-stress effect of saponins extracted from panax ginseng fruit and the hypophyseal-adrenal system (author's transl)].[Article in Chinese] by Zhang SC, Jiang XL.(PubMed)
(1144) Ginseng and the hypothalamic-pituitary control of stress by Fulder SJ.(PubMed)
(1145) Stimulation of pituitary-adrenocortical system by ginseng saponin by Hiai S, Yokoyama H, Oura H, Yano S.(PubMed)
(1146) [Study on the mechanism of action of total saponins of Panax notoginseng in ameliorating oxidative stress and insulin resistance in rats fed with high fat diet].[Article in Chinese] by Zhang SS1, Wu ZY2, Chen JM3, Guo QK2, Li L2, Wang ZF2, Gao Y4, Ma ZC4.(PubMed)
(1147) [Effects of ginsenosides on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factor in rats exposed to chronic unpredictable mild stress].[Article in Chinese] by Liu L1, Luo Y, Zhang R, Guo J.(PubMed)
(1148) Modulation of nitrergic signalling pathway by American ginseng attenuates chronic unpredictable stress-induced cognitive impairment, neuroinflammation, and biochemical alterations by Rinwa P1, Kumar A.(PubMed)
(1149) Ginsenoside Rb3 exerts antidepressant-like effects in several animal models by Cui J1, Jiang L, Xiang H.(PubMed)
(1150) Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression by Dang H1, Chen Y, Liu X, Wang Q, Wang L, Jia W, Wang Y.(PubMed)
(1151) Role of Endoplasmic Reticulum Stress in Metabolic Disease and Other Disorders by Lale Ozcan and Ira Tabas(PubMed)
(1152) Traditional chinese medicine in treatment of metabolic syndrome by Yin J1, Zhang H, Ye J.(PubMed)
The best weightloss, weightwatching and healthy recipe: Sauerkraut salad
Posted By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Recipes contributed by Company's Coming Salads by Jean Pare
And there the similarly ends. Even if you don't like sauerkraut, you will love this tasty salad. very attractive.
Canned sauerkraut, drained 28oz. (796 ml)
Diced celery 1 cup (250ml)
Diced green pepper 1 cup (250ml)
Diced onion 1/4 cup (50ml)
Small jar pimentos, chopped 1
Granulated sugar 3/4 cup (175ml)
Salt 1/2 tsp. (2 ml)
Pepper 1/8 tsp. (0.5 ml)
Celery seed 1 tsp. (5ml)
Vinegar 3 tbsp. (50ml)
Rinse sauerkraut. Squeeze dry and chop. Put into large bowl.
Add rest of ingredients in order. Mix well. Let stand covered in refrigerator overnight before serving. Serve 10.
Weight Loss the Easy Ways
Andrea Albright Featured on Health and Fitness Jan. 2015
will Personally Coach You How to Get There The Easy Way
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Recipes contributed by Company's Coming Salads by Jean Pare
And there the similarly ends. Even if you don't like sauerkraut, you will love this tasty salad. very attractive.
Canned sauerkraut, drained 28oz. (796 ml)
Diced celery 1 cup (250ml)
Diced green pepper 1 cup (250ml)
Diced onion 1/4 cup (50ml)
Small jar pimentos, chopped 1
Granulated sugar 3/4 cup (175ml)
Salt 1/2 tsp. (2 ml)
Pepper 1/8 tsp. (0.5 ml)
Celery seed 1 tsp. (5ml)
Vinegar 3 tbsp. (50ml)
Rinse sauerkraut. Squeeze dry and chop. Put into large bowl.
Add rest of ingredients in order. Mix well. Let stand covered in refrigerator overnight before serving. Serve 10.
Weight Loss the Easy Ways
Andrea Albright Featured on Health and Fitness Jan. 2015
will Personally Coach You How to Get There The Easy Way
Monday, 11 May 2015
The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: The Stress Response and Management herbal Ashwagandha
By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Polycystic Ovarian Syndrome
Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).
In Herbal Medicine Perspective
The prevention and management
Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.
Reduce fat intake less than 30% of total calories with a low proportion of saturated fat and high in fiber from predominantly low-glycaemic-index-carbohydrate foods for patients with PCOs(827a). Calorie intake should be distributed between several meals per day with restricted intake of snacks and drinks(828).
The stress management herbs
Stress in a natural reaction of human fight or fight response induced by pressure due to environmental condition or a stimulus. Long term stress can cause deleterious and cumulative effects on human body(1104), including emotional or cognitive problems, such as an increased risk of attentional deficit/hyperactivity, anxiety, and language delay(1103), especially for people with chronic illness, including women with Polycystic Ovarian Syndrome (PCOs)(1105).
Ashwagandha (Withania somnifera)
Ashwagandha(Withania somnifera), also known as Indian Ginseng is a nightshade plant belongings to the family Solanaceae, native to India, northern Africa, and the Middle East, used in Ayurvedic medicine over 3000 years(1101) as antitumors(1107)(1108), anti ulcers(1111), anti-stress(1112)(1115)(1118), improved cognition dysfunction(1109)(1110)(1118), anti-inflammatory(1113)(1116), antioxidant(1114)(1117), promoted immunity(1120)(1121), anti-aging(1119), etc., herbal medicine.
Phytochemicals(1102)
1. Isopelletierine
2. Anaferine
3. Cuseohygrine
4. Anahygrine
5. Withanolides
6. Withaferins
7. Saponins
8. Sitoindosides
9. Acylsterylglucosides
10. Z-Guggulsterone(1106)
10. Etc.
Epidemiologically strong evidences suggested that herbal ashwagandha processes anti stress related disorders( induced by oxidative stress(1122)(1123) and long term stress(1123) effects, probably through its antioxidant(1123)(1124)(1126)(1114)(1117), anti-stress(1112)(1115)(1118), anti-inflammatory(1113)(1116), immunomoduratory(1120)(1121) effects. In rat model, hydroalcoholic extract exerted its antioxidant effect against psychological symptoms(1132) induced by long term stress, such as reduced motor performance(1124), cognitive impairment(1125)(1126, anxiety(1127)(1128), sleep disorder(1129)(1130), depression(1131), etc. In stress induced by phyisological symptoms, the herb has showen to reduce fatigue(1133) risk of hypertension(1134), risk of stroke(1135). risk of diabetes(1136), improve energy(1132), etc.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(827a) Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management by Farshchi H, Rane A, Love A, Kennedy RL(PubMed)
(828) The optimal diet for women with polycystic ovary syndrome? by Marsh K, Brand-Miller J.(PubMed) (1106) Simultaneous Estimation of Withaferin A and Z-Guggulsterone in Marketed Formulation by RP-HPLC by Agrawal P1, Vegda R2, Laddha K2.(PubMed)
(1101) Steroidal lactones from Withania somnifera, an ancient plant for novel medicine by Mirjalili MH, Moyano E, Bonfill M, Cusido RM, Palazón J.(PubMed)
(1102) An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda by Narendra Singh, Mohit Bhalla, Prashanti de Jager, and Marilena Gilca(PubMed)
(1103) Antenatal maternal stress and long-term effects on child neurodevelopment: how and why? by Talge NM1, Neal C, Glover V; Early Stress, Translational Research and Prevention Science Network: Fetal and Neonatal Experience on Child and Adolescent Mental Health.(PubMed)
(1104) Immediate and long-term effects of meditation on acute stress reactivity, cognitive functions, and intelligence by Singh Y1, Sharma R, Talwar A.(PubMed)
(1105) The potential implications of a PCOS diagnosis on a woman's long-term health using data linkage by Hart R1, Doherty DA.(PubMed)
(1106) Simultaneous Estimation of Withaferin A and Z-Guggulsterone in Marketed Formulation by RP-HPLC by Agrawal P1, Vegda R2, Laddha K2.(PubMed)
(1107) Selective killing of cancer cells by leaf extract of Ashwagandha: components, activity and pathway analyses by Widodo N1, Takagi Y, Shrestha BG, Ishii T, Kaul SC, Wadhwa R.(PubMed)
(1108) Selective killing of cancer cells by leaf extract of Ashwagandha: identification of a tumor-inhibitory factor and the first molecular insights to its effect by Widodo N1, Kaur K, Shrestha BG, Takagi Y, Ishii T, Wadhwa R, Kaul SC.(PubMed)
(1109) Effect of standardized aqueous extract of Withania somnifera on tests of cognitive and psychomotor performance in healthy human participants by Pingali U1, Pilli R1, Fatima N1.(PubMed)
(1110) Randomized placebo-controlled adjunctive study of an extract of withania somnifera for cognitive dysfunction in bipolar disorder by Chengappa KN1, Bowie CR, Schlicht PJ, Fleet D, Brar JS, Jindal R.(PubMed)
(1111) Evaluation of the anti-ulcer activity of NR-ANX-C (a polyherbal formulation) in aspirin & pyloric ligature induced gastric ulcers in albino rats by Nair V1, Arjuman A, Gopalakrishna HN, Dorababu P, Mirshad PV, Bhargavan D, Chatterji D.(PubMed)
(1112) Effect of Withania somnifera (Ashwagandha) root extract on amelioration of oxidative stress and autoantibodies production in collagen-induced arthritic rats by Khan MA, Subramaneyaan M, Arora VK, Banerjee BD, Ahmed RS.(PubMed)
(1113) Evaluation of anti-inflammatory effect of Withania somnifera root on collagen-induced arthritis in rats by Gupta A1, Singh S.(PubMed)
(1114) Protective effect of Withania somnifera root powder in relation to lipid peroxidation, antioxidant status, glycoproteins and bone collagen on adjuvant-induced arthritis in rats by Rasool M1, Varalakshmi P.(PubMed)
(1115) Withania somnifera Improves Semen Quality in Stress-Related Male Fertility by Mahdi AA1, Shukla KK, Ahmad MK, Rajender S, Shankhwar SN, Singh V, Dalela D.(PubMed)
(1116) Withaferin A inhibits pro-inflammatory cytokine-induced damage to islets in culture and following transplantation by SoRelle JA1, Itoh T, Peng H, Kanak MA, Sugimoto K, Matsumoto S, Levy MF, Lawrence MC, Naziruddin B.(PubMed)
(1117) Evaluation of antioxidant potential of Rasayana drugs in healthy human volunteers by Kuchewar VV1, Borkar MA2, Nisargandha MA3.(PubMed)
(1118) Withania somnifera (Ashwagandha) in neurobehavioural disorders induced by brain oxidative stress in rodents: a systematic review and meta-analysis by Durg S1, Dhadde SB, Vandal R, Shivakumar BS, Charan CS.(PubMed)
(1119) In vitro protective effects of Withania somnifera (L.) dunal root extract against hydrogen peroxide and β-amyloid(1-42)-induced cytotoxicity in differentiated PC12 cells by Kumar S1, Seal CJ, Howes MJ, Kite GC, Okello EJ.(PubMed)
(1120) Chemotypical variations in Withania somnifera lead to differentially modulated immune response in BALB/c mice by Kushwaha S1, Roy S, Maity R, Mallick A, Soni VK, Singh PK, Chaurasiya ND, Sangwan RS, Misra-Bhattacharya S, Mandal C.(PubMed)
(1121) Molecular insight into the immune up-regulatory properties of the leaf extract of Ashwagandha and identification of Th1 immunostimulatory chemical entity by Khan S1, Malik F, Suri KA, Singh J.(PubMed)
(1122) Evaluation of the anti-proliferative and anti-oxidative activities of leaf extract from in vivo and in vitro raised Ashwagandha by Kaur K1, Rani G, Widodo N, Nagpal A, Taira K, Kaul SC, Wadhwa R.(PubMed)
(1123) Anti-oxidant effect of Withania somnifera glycowithanolides in chronic footshock stress-induced perturbations of oxidative free radical scavenging enzymes and lipid peroxidation in rat frontal cortex and striatum by Bhattacharya A1, Ghosal S, Bhattacharya SK.(PubMed)
(1124) Evaluation of Withania somnifera in a middle cerebral artery occlusion model of stroke in rats by Chaudhary G1, Sharma U, Jagannathan NR, Gupta YK.(PubMed)
(1125) Propoxur-induced acetylcholine esterase inhibition and impairment of cognitive function: attenuation by Withania somnifera by Yadav CS1, Kumar V, Suke SG, Ahmed RS, Mediratta PK, Banerjee BD.(PubMed)
(1126) Attenuation of oxidative damage-associated cognitive decline by Withania somnifera in rat model of streptozotocin-induced cognitive impairment by Ahmed ME1, Javed H, Khan MM, Vaibhav K, Ahmad A, Khan A, Tabassum R, Islam F, Safhi MM, Islam F.(PubMed)
(1127) An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera) by Pratte MA1, Nanavati KB, Young V, Morley CP.(PubMed)
(1128) Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence by Sarris J1, McIntyre E, Camfield DA.(PubMed)
(1129) Effect of Withania somnifera on Sleep-Wake Cycle in Sleep-Disturbed Rats: Possible GABAergic Mechanism by Kumar A1, Kalonia H.(PubMed)
(1130) Protective effect of Withania somnifera Dunal on the behavioral and biochemical alterations in sleep-disturbed mice (Grid over water suspended method) by Kumar A1, Kalonia H.(PubMed)
(1131) Protective effect of Withania somnifera dunal root extract against protracted social isolation induced behavior in rats by Gupta GL1, Rana AC.(PubMed)
(1132) An overview on ashwagandha: a Rasayana (rejuvenator) of Ayurveda by Singh N1, Bhalla M, de Jager P, Gilca M.(PubMed)
(1133) Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients by Biswal BM1, Sulaiman SA, Ismail HC, Zakaria H, Musa KI.(PubMed)
(1134) Withania somnifera shows a protective effect in monocrotaline-induced pulmonary hypertension by Kaur G1, Singh N, Samuel SS, Bora HK, Sharma S, Pachauri SD, Dwivedi AK, Siddiqui HH, Hanif K.(PubMed)
(1135) Withania somnifera Improves Ischemic Stroke Outcomes by Attenuating PARP1-AIF-Mediated Caspase-Independent Apoptosis by Raghavan A1, Shah ZA.(PubMed)
(1136) The aqueous extract of Withania coagulans fruit partially reverses nicotinamide/streptozotocin-induced diabetes mellitus in rats by Shukla K1, Dikshit P, Shukla R, Gambhir JK.(PubMed)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Polycystic Ovarian Syndrome
Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).
In Herbal Medicine Perspective
The prevention and management
Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.
Reduce fat intake less than 30% of total calories with a low proportion of saturated fat and high in fiber from predominantly low-glycaemic-index-carbohydrate foods for patients with PCOs(827a). Calorie intake should be distributed between several meals per day with restricted intake of snacks and drinks(828).
The stress management herbs
Stress in a natural reaction of human fight or fight response induced by pressure due to environmental condition or a stimulus. Long term stress can cause deleterious and cumulative effects on human body(1104), including emotional or cognitive problems, such as an increased risk of attentional deficit/hyperactivity, anxiety, and language delay(1103), especially for people with chronic illness, including women with Polycystic Ovarian Syndrome (PCOs)(1105).
Ashwagandha (Withania somnifera)
Ashwagandha(Withania somnifera), also known as Indian Ginseng is a nightshade plant belongings to the family Solanaceae, native to India, northern Africa, and the Middle East, used in Ayurvedic medicine over 3000 years(1101) as antitumors(1107)(1108), anti ulcers(1111), anti-stress(1112)(1115)(1118), improved cognition dysfunction(1109)(1110)(1118), anti-inflammatory(1113)(1116), antioxidant(1114)(1117), promoted immunity(1120)(1121), anti-aging(1119), etc., herbal medicine.
Phytochemicals(1102)
1. Isopelletierine
2. Anaferine
3. Cuseohygrine
4. Anahygrine
5. Withanolides
6. Withaferins
7. Saponins
8. Sitoindosides
9. Acylsterylglucosides
10. Z-Guggulsterone(1106)
10. Etc.
Epidemiologically strong evidences suggested that herbal ashwagandha processes anti stress related disorders( induced by oxidative stress(1122)(1123) and long term stress(1123) effects, probably through its antioxidant(1123)(1124)(1126)(1114)(1117), anti-stress(1112)(1115)(1118), anti-inflammatory(1113)(1116), immunomoduratory(1120)(1121) effects. In rat model, hydroalcoholic extract exerted its antioxidant effect against psychological symptoms(1132) induced by long term stress, such as reduced motor performance(1124), cognitive impairment(1125)(1126, anxiety(1127)(1128), sleep disorder(1129)(1130), depression(1131), etc. In stress induced by phyisological symptoms, the herb has showen to reduce fatigue(1133) risk of hypertension(1134), risk of stroke(1135). risk of diabetes(1136), improve energy(1132), etc.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(827a) Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management by Farshchi H, Rane A, Love A, Kennedy RL(PubMed)
(828) The optimal diet for women with polycystic ovary syndrome? by Marsh K, Brand-Miller J.(PubMed) (1106) Simultaneous Estimation of Withaferin A and Z-Guggulsterone in Marketed Formulation by RP-HPLC by Agrawal P1, Vegda R2, Laddha K2.(PubMed)
(1101) Steroidal lactones from Withania somnifera, an ancient plant for novel medicine by Mirjalili MH, Moyano E, Bonfill M, Cusido RM, Palazón J.(PubMed)
(1102) An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda by Narendra Singh, Mohit Bhalla, Prashanti de Jager, and Marilena Gilca(PubMed)
(1103) Antenatal maternal stress and long-term effects on child neurodevelopment: how and why? by Talge NM1, Neal C, Glover V; Early Stress, Translational Research and Prevention Science Network: Fetal and Neonatal Experience on Child and Adolescent Mental Health.(PubMed)
(1104) Immediate and long-term effects of meditation on acute stress reactivity, cognitive functions, and intelligence by Singh Y1, Sharma R, Talwar A.(PubMed)
(1105) The potential implications of a PCOS diagnosis on a woman's long-term health using data linkage by Hart R1, Doherty DA.(PubMed)
(1106) Simultaneous Estimation of Withaferin A and Z-Guggulsterone in Marketed Formulation by RP-HPLC by Agrawal P1, Vegda R2, Laddha K2.(PubMed)
(1107) Selective killing of cancer cells by leaf extract of Ashwagandha: components, activity and pathway analyses by Widodo N1, Takagi Y, Shrestha BG, Ishii T, Kaul SC, Wadhwa R.(PubMed)
(1108) Selective killing of cancer cells by leaf extract of Ashwagandha: identification of a tumor-inhibitory factor and the first molecular insights to its effect by Widodo N1, Kaur K, Shrestha BG, Takagi Y, Ishii T, Wadhwa R, Kaul SC.(PubMed)
(1109) Effect of standardized aqueous extract of Withania somnifera on tests of cognitive and psychomotor performance in healthy human participants by Pingali U1, Pilli R1, Fatima N1.(PubMed)
(1110) Randomized placebo-controlled adjunctive study of an extract of withania somnifera for cognitive dysfunction in bipolar disorder by Chengappa KN1, Bowie CR, Schlicht PJ, Fleet D, Brar JS, Jindal R.(PubMed)
(1111) Evaluation of the anti-ulcer activity of NR-ANX-C (a polyherbal formulation) in aspirin & pyloric ligature induced gastric ulcers in albino rats by Nair V1, Arjuman A, Gopalakrishna HN, Dorababu P, Mirshad PV, Bhargavan D, Chatterji D.(PubMed)
(1112) Effect of Withania somnifera (Ashwagandha) root extract on amelioration of oxidative stress and autoantibodies production in collagen-induced arthritic rats by Khan MA, Subramaneyaan M, Arora VK, Banerjee BD, Ahmed RS.(PubMed)
(1113) Evaluation of anti-inflammatory effect of Withania somnifera root on collagen-induced arthritis in rats by Gupta A1, Singh S.(PubMed)
(1114) Protective effect of Withania somnifera root powder in relation to lipid peroxidation, antioxidant status, glycoproteins and bone collagen on adjuvant-induced arthritis in rats by Rasool M1, Varalakshmi P.(PubMed)
(1115) Withania somnifera Improves Semen Quality in Stress-Related Male Fertility by Mahdi AA1, Shukla KK, Ahmad MK, Rajender S, Shankhwar SN, Singh V, Dalela D.(PubMed)
(1116) Withaferin A inhibits pro-inflammatory cytokine-induced damage to islets in culture and following transplantation by SoRelle JA1, Itoh T, Peng H, Kanak MA, Sugimoto K, Matsumoto S, Levy MF, Lawrence MC, Naziruddin B.(PubMed)
(1117) Evaluation of antioxidant potential of Rasayana drugs in healthy human volunteers by Kuchewar VV1, Borkar MA2, Nisargandha MA3.(PubMed)
(1118) Withania somnifera (Ashwagandha) in neurobehavioural disorders induced by brain oxidative stress in rodents: a systematic review and meta-analysis by Durg S1, Dhadde SB, Vandal R, Shivakumar BS, Charan CS.(PubMed)
(1119) In vitro protective effects of Withania somnifera (L.) dunal root extract against hydrogen peroxide and β-amyloid(1-42)-induced cytotoxicity in differentiated PC12 cells by Kumar S1, Seal CJ, Howes MJ, Kite GC, Okello EJ.(PubMed)
(1120) Chemotypical variations in Withania somnifera lead to differentially modulated immune response in BALB/c mice by Kushwaha S1, Roy S, Maity R, Mallick A, Soni VK, Singh PK, Chaurasiya ND, Sangwan RS, Misra-Bhattacharya S, Mandal C.(PubMed)
(1121) Molecular insight into the immune up-regulatory properties of the leaf extract of Ashwagandha and identification of Th1 immunostimulatory chemical entity by Khan S1, Malik F, Suri KA, Singh J.(PubMed)
(1122) Evaluation of the anti-proliferative and anti-oxidative activities of leaf extract from in vivo and in vitro raised Ashwagandha by Kaur K1, Rani G, Widodo N, Nagpal A, Taira K, Kaul SC, Wadhwa R.(PubMed)
(1123) Anti-oxidant effect of Withania somnifera glycowithanolides in chronic footshock stress-induced perturbations of oxidative free radical scavenging enzymes and lipid peroxidation in rat frontal cortex and striatum by Bhattacharya A1, Ghosal S, Bhattacharya SK.(PubMed)
(1124) Evaluation of Withania somnifera in a middle cerebral artery occlusion model of stroke in rats by Chaudhary G1, Sharma U, Jagannathan NR, Gupta YK.(PubMed)
(1125) Propoxur-induced acetylcholine esterase inhibition and impairment of cognitive function: attenuation by Withania somnifera by Yadav CS1, Kumar V, Suke SG, Ahmed RS, Mediratta PK, Banerjee BD.(PubMed)
(1126) Attenuation of oxidative damage-associated cognitive decline by Withania somnifera in rat model of streptozotocin-induced cognitive impairment by Ahmed ME1, Javed H, Khan MM, Vaibhav K, Ahmad A, Khan A, Tabassum R, Islam F, Safhi MM, Islam F.(PubMed)
(1127) An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera) by Pratte MA1, Nanavati KB, Young V, Morley CP.(PubMed)
(1128) Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence by Sarris J1, McIntyre E, Camfield DA.(PubMed)
(1129) Effect of Withania somnifera on Sleep-Wake Cycle in Sleep-Disturbed Rats: Possible GABAergic Mechanism by Kumar A1, Kalonia H.(PubMed)
(1130) Protective effect of Withania somnifera Dunal on the behavioral and biochemical alterations in sleep-disturbed mice (Grid over water suspended method) by Kumar A1, Kalonia H.(PubMed)
(1131) Protective effect of Withania somnifera dunal root extract against protracted social isolation induced behavior in rats by Gupta GL1, Rana AC.(PubMed)
(1132) An overview on ashwagandha: a Rasayana (rejuvenator) of Ayurveda by Singh N1, Bhalla M, de Jager P, Gilca M.(PubMed)
(1133) Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients by Biswal BM1, Sulaiman SA, Ismail HC, Zakaria H, Musa KI.(PubMed)
(1134) Withania somnifera shows a protective effect in monocrotaline-induced pulmonary hypertension by Kaur G1, Singh N, Samuel SS, Bora HK, Sharma S, Pachauri SD, Dwivedi AK, Siddiqui HH, Hanif K.(PubMed)
(1135) Withania somnifera Improves Ischemic Stroke Outcomes by Attenuating PARP1-AIF-Mediated Caspase-Independent Apoptosis by Raghavan A1, Shah ZA.(PubMed)
(1136) The aqueous extract of Withania coagulans fruit partially reverses nicotinamide/streptozotocin-induced diabetes mellitus in rats by Shukla K1, Dikshit P, Shukla R, Gambhir JK.(PubMed)
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