Tuesday, 5 August 2014

Obesity Complication of Gastroesophageal Reflux Disease (Heart Burn)

By Kyle J. Norton

Obesity is defined as a medical condition of excess body fat has accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.

How to calculate your BMI index
BMI= weight (kg)/ height (m2)

 Gastroesophageal reflux disease (GERD), also known as gastro-oesophageal reflux disease (GORD), gastric reflux disease, or acid reflux disease, is defined as a chronic condition of liquid stomach acid refluxing back up from the stomach into the esophagus, causing heartburn. According to the study of "Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease." by DeVault KR, Castell DO; American College of Gastroenterology, GERD is defined as symptoms or mucosal damage produced by the abnormal reflux of gastric contents into the esophagus.

D. How Obesity associates with Gastroesophageal Reflux Disease (Heart Burn)
1. According to the study of "Prevalence and risk factors for gastroesophageal reflux disease in an impoverished minority population" by Friedenberg FK, Rai J, Vanar V, Bongiorno C, Nelson DB, Parepally M, Poonia A, Sharma A, Gohel S, Richter JE., posted in PubMed, researchers found that Increasing waist circumference, but not overall body mass index or waist-hip ratio, and smoking are risk factors for prevalent GERD. No association between reflux disease and lifestyle choices such as coffee drinking and fast food dining were found.

2. In a study of "Does BMI affect the clinical efficacy of proton pump inhibitor therapy in GERD? The case for rabeprazole" by Pace F, Coudsy B, Delemos B, Sun Y, Xiang J, Lococo J, Casalini S, Li H, Pelosini I, Scarpignato C., posted in PubMed, researchers comcluded that Results of this study show that the clinical efficacy of rabeprazole is maintained in overweight/obese patients with gastroesophageal reflux disease and suggest that this subgroup of patients may derive, from rabeprazole, even greater benefit than lean patients.

3. In the abstract of the study of "Effects of environment and lifestyle on gastroesophageal reflux disease" by Sonnenberg A., posted in PubMed, researchers stated that Overweight and obesity contribute to the development of hiatal hernia, increase intra-abdominal pressure, and promote gastroesophageal reflux. Weight gain increases reflux symptoms, whereas weight loss decreases such symptoms. Other risk factors, such as smoking, alcohol, dietary fat, or drugs, play only a minor role in shaping the epidemiologic patterns of GERD. PROTECTION THROUGH HELICOBACTER PYLORI: On a population level, a high prevalence of H. pylori infection is likely to reduce levels of acid secretion and protect some carriers of the infection against reflux disease and its associated complications.

4. According to the study of "Gastroesophageal reflux disease and morbid obesity: is there a relation?" by Fisichella PM, Patti MG., posted in PubMed, researchers found that Although many advances have been made in the understanding of the pathophysiology of GERD, many aspects of the pathophysiology of this disease in morbidly obese patients remain unclear. The following review describes the current evidence linking esophageal reflux to obesity, covering the pathophysiology of the disease and the implications for treatment of GERD in the obese patient.

5. In the abstract of the study of "Obesity and gastroesophageal reflux: quantifying the association between body mass index, esophageal acid exposure, and lower esophageal sphincter status in a large series of patients with reflux symptoms" by Ayazi S, Hagen JA, Chan LS, DeMeester SR, Lin MW, Ayazi A, Leers JM, Oezcelik A, Banki F, Lipham JC, DeMeester TR, Crookes PF., posted in PubMed, researchers found that An increase in body mass index is associated with an increase in esophageal acid exposure, whether BMI was examined as a continuous or as a categorical variable; 13% of the variation in esophageal acid exposure may be attributable to variation in BMI.

6. Etc.


Treatments of Obesity and Gastroesophageal Reflux Disease (Heart Burn)
1. According to the study of "Gastroesophageal reflux disease is inversely related with glycemic control in morbidly obese patients" by Lauffer A, Forcelini CM, Ruas LO, Madalosso CA, Fornari F., posted in PubMed, researchers found that This study suggests an inverse relation between glycemic control and GERD in morbidly obese patients. This can be partially explained by a lower frequency of hiatal hernia in patients with very poor glycemic control.

2. In the study of "Gastroesophageal reflux disease and obesity. Pathophysiology and implications for treatment" by Herbella FA, Sweet MP, Tedesco P, Nipomnick I, Patti MG., posted in PubMed, researchers indicated that A linear regression model showed that BMI, LES pressure, LES abdominal length, and DEA were independently associated with the DeMeester score. These data showed that: (a) BMI was independently associated to the severity of GERD; and (b) in most morbidly obese patients with GERD, reflux occurred despite normal or hypertensive esophageal motility. These findings show that the pathophysiology of GERD in morbidly obese patients might differ from that of nonobese patients, suggesting the need for a different therapeutic approach.

3. Etc.

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The recipe for Spiced nuts and seeds lovers: Spiced chili nuts and seeds

Recipe attributed to Fresh and Easy Meals by Better Homes and Gardens

Pick your favorite nuts and seed for this snack recipe. Orange juice concentration spiked with piquant spices gives the mixture a burst of favor.

Prep. 10 minutes
Bake 15 minutes
Oven 300 degrees F
Make 16 (1/4 cup) serving

2 tsp. frozen orange juice concentrate thawed.
2 tsp. Worcestershire sauce
1 tsp. garlic powder
1 tsp. ground cumin
1 tsp. chili powder
1/2 tsp. cayenne pepper
1/4 tsp. salt
1/4 tsp. ground allspice
1.4 tsp. onion salt
2 cups unsalted peanuts, hazelnuts, and/or Brazil nuts
1 cup pecan halves
6 tsp. unsalted shelled sunflower seeds
2 tsp. sesame seeds
Non stick cooking tray

In a large bowl, combined orange juice concentrate, Worcestershire sauce, garlic powder, cumin, chili powder, cayenne pepper,salt, allspice, black pepper and onion salt. Stir in nuts and seeds; toss to coat.
Line a 15x10x1 inch baking pan with foil; slightly coat with nonstick cooking spray. Spread nuts and seed on foil. Bake in a300 degrees oven for 15 to 20 minutes or until toasted, stirring once. Cool. Store in an airtight container at room temperature for up to 1 week.
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The best Chinese Rice and Chicken recipe: Chicken and egg fried rice

Recipe attributed to 125 best  Chinese recipes by Bill Jones and Stephen Wong, published by Robert Rose

11/2 tbsp. vegetable oil  20mL
3 eggs, beaten   3
Salt and pepper to taste
1 tbsp. minced ginger root   15 mL
2 green onion, finely chopped  2
2 cups diced cooked chicken meat 500mL
2 tbsp. chicken stock  25mL
1/2 cup frozen peas  125mL
1/2 cup can corn kernel 125 mL
3 cups cooked rice
Salt and pepper to taste
1. In a nonstick wok or skillet, heat 1/2 tbsp. (7mL) oil over medium heat. Add eggs; cook to make a thin omelet by swirling the pan so eggs flow onto as large a surface as possible. Season lightly with salt and pepper. Remove, chop coarsely and set aside
2. Heat remaining oil in wok over medium heat. Add ginger root and onion; fry until fragrant. about 30 seconds. Add chicken, chicken stock, pepper, peas and corn; stir 2 minutes. Add eggs and stir to mix well. Season with salt and pepper; stir to mix. Serve immediately. Serve 4.

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Monday, 4 August 2014

Obesity Complication of Hypertension

By Kyle J. Norton

Obesity is defined as a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.

 How to calculate your BMI index
BMI= weight (kg)/ height (m2)

 Hypertension, also known as high blood pressure is defined as a condition of elevation of systemic arterial blood pressure.

 How Obesity associates with Hypertension
1. According to the study of "
Links between childhood and adult social circumstances and obesity and hypertension in the mexican population" by Beltrán-Sánchez H, Crimmins EM, Teruel GM, Thomas D., posted in PubMed, researchers found that Recent changes in income, nutrition, and infection in Mexico may be responsible for the observed high prevalence of overweight and obesity and the extremely high odds of hypertension among obese young adults.

2. In the abstract of the study of "Health-related quality of life and awareness of hypertension" by Korhonen PE, Kivelä SL, Kautiainen H, Järvenpää S, Kantola I., posted in PubMed, researchers indicated that Impaired HRQoL in hypertensive patients might be secondary to the awareness of hypertension, adverse drug effects, newly diagnosed type 2 diabetes or obesity, not high blood pressure per se.

3. In the abstract of the study of " Dietary phytochemicals and their potential effects on obesity: A review" by González-Castejón M, Rodriguez-Casado A., posted in PubMed, researchers stated that The incidence of obesity is rising at an alarming rate and is becoming a major public health concern with incalculable social costs. Indeed, obesity facilitates the development of metabolic disorders such as diabetes, hypertension, and cardiovascular diseases in addition to chronic diseases such as stroke, osteoarthritis, sleep apnea, some cancers, and inflammation-bases pathologies.

4. According to the study of "Arterial hypertension in overweight and obese algerian adolescents: Role of abdominal adiposity" by Benmohammed K, Nguyen MT, Khensal S, Valensi P, Lezzar A., posted in PubMed, researchers concluded that The prevalence of hypertension is high in overweight and obese adolescents, and higher in boys than in girls. Hypertension and arterial stiffness, as determined by high PP levels, were associated with abdominal adiposity. It is recommended that prehypertension be identified in overweight adolescents and that lifestyle changes be made to avoid its evolution towards obesity and hypertension.

5. In the study of "Role of waist circumference in predicting the risk of high blood pressure in children" by Kovacs VA, Gabor A, Fajcsak Z, Martos E., posted in PubMed, researchers indicated that The ability of WC to detect high-risk normal weight children is controversial. The additional measure of WC among overweight children seems to be relevant in identifying those at increased risk of high BP. Further research with a larger sample size is required in the obese group.

6. in Another study of "Blood pressure: effect of body mass index and of waist circumference on adolescents" [Article in English, Portuguese] by Guimarães IC, de Almeida AM, Santos AS, Barbosa DB, Guimarães AC., posted in PubMed, researchers concluded that BMI and WC values have a strong influence on BP values in adolescents.

7. Etc.

Treatments of Obesity and Hypertension
1. In a study of "Best strategies for hypertension management in type 2 diabetes and obesity" by Allcock DM, Sowers JR., posted in PubMed, researchers indicated that significant research and effort must be put forth to bring blood pressure to goal and delay or prevent target organ damage. Such efforts should frequently include a dihydropyridine calcium channel blocker such as amlodipine. Other agents that are currently underused in this population for the treatment of resistant hypertension include nebivolol, carvedilol, aliskiren, and aldosterone antagonists. Finally, significant potential is seen for darusentan, an endothelin antagonist, if it comes to market.

2. According to the study of "The 2004 Canadian recommendations for the management of hypertension: Part II--Therapy" by Khan NA, McAlister FA, Campbell NR, Feldman RD, Rabkin S, Mahon J, Lewanczuk R, Zarnke KB, Hemmelgarn B, Lebel M, Levine M, Herbert C; Canadian Hypertension Education Program., posted in PubMed, researchers stated
that This document contains detailed recommendations and supporting evidence on treatment thresholds, target blood pressures and choice of agents for hypertensive patients with or without comorbidities. Lifestyle modifications are a key component of any antiatherosclerotic management strategy and detailed recommendations are contained in a separate document. Key recommendations for pharmacotherapy include the following: treatment thresholds and targets should take into account each individual's global atherosclerotic risk, target organ damage and comorbidities, with particular attention to systolic blood pressure; blood pressure should be lowered to 140/90 mmHg or less in all patients, and 130/80 mmHg or less in those with diabetes mellitus or renal disease (125/75 mmHg or less in those with nondiabetic renal disease and more than 1 g of proteinuria per day); most adults with hypertension require more than one agent to achieve target blood pressures; for adults without compelling indications for other agents, initial therapy should include thiazide diuretics; other agents appropriate for first-line therapy for diastolic hypertension with or without systolic hypertension include beta-blockers (in those younger than 60 years), ACE inhibitors (in non-Blacks), long-acting dihydropyridine CCBs or angiotensin receptor antagonists; other agents appropriate for first-line therapy for isolated systolic hypertension include long-acting dihydropyridine CCBs or angiotensin receptor antagonists; certain comorbidities provide compelling indications for first-line use of other agents: in patients with angina, recent myocardial infarction or heart failure, beta-blockers and ACE inhibitors are recommended as first-line therapy; in patients with diabetes mellitus, ACE inhibitors or angiotensin receptor antagonists (or thiazides in patients with diabetes mellitus without albuminuria) are appropriate first-line therapies; and in patients with mild to moderate nondiabetic renal disease, ACE inhibitors are recommended; all hypertensive patients should have their fasting lipids screened and those with dyslipidemia should be treated using the thresholds, targets and agents as per the Recommendations for the management of dyslipidemia and the prevention of cardiovascular disease; and selected patients with hypertension should also receive statin and/or acetylsalicylic acid therapy.

3. In another study of "A comparison of the efficacy and safety of irbesartan/hydrochlorothiazide combination therapy with irbesartan monotherapy in the treatment of moderate or severe hypertension in diabetic and obese hypertensive patients: a post-hoc analysis review" by Neutel JM., posted in PubMed, researcher indicated that Treatment-emergent adverse event rates were similar between treatment groups regardless of the presence of diabetes or body mass index (BMI) status. In patients with moderate or severe hypertension and with a BMI ≥ 30 kg/m(2), initial treatment with irbesartan/HCTZ combination therapy was more effective than irbesartan monotherapy.

4. Etc.
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The best rice Chinese recipe: Fried rice with Anchovies and cilantro

Recipe attributed to 125 best  Chinese recipes by Bill Jones and Stephen Wong, published by Robert Rose

1 tbsp. vegetable oil  15mL
4  oil-packed anchovy fillets   4
1tbsp. minced ginger root  15mL
3 cups cooked rice 750mL
1tbsp. chicken stock  15mL
1/4 cup finely chopped cilantro  50mL
salt and pepper to taste
1. In a nonstick wok or skillet, heat oil over medium heat. Add anchovies and ginger root; fry until fragrant, about 30 second.
2 Add rice and stir fry until the anchovy mixture is thoroughly integrated and the grains are separate, about 2 minutes, Add chicken stock; stir and cook until rice is heated through, about 1 minute. (Add more chicken stock if rice appears too dry). Add cilantro, stir to combine. Season with salt and pepper; stir to mix. Serve immediately. Make 4 serving.

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The Tasters' buds surprised Brie baguette Bites

Recipe attributed to 30 minutes vegetarian recipes by Marie-laude Morin, Publisher Robert Rose at www,robertrose.ca

The sweet taste of these little hors d'oeuvres will surprise with your taster buds.
Preheated oven to 350 degree F (180 degree C)
Baking sheet, lined with parchment paper.
12 pecan halves  12
12   1/2 inch (1cm) slice baguette   12
Dijon mustard
12 sliced Brie cheese  12
Pure maple syrup
1. In a dry skillet over medium heat, toast pecans, stirring constantly for about 5 minutes or until golden and fragrant. Remove from heat.
2. Place baguette slices on prepared baking sheet. Spread Dijon mustard to taste over 1 side of each slice. Top each slice with Brie and a toasted pecan.
3. Drizzle maple syrup over top. Bake in preheated oven for about 1 minutes or until cheese is melted. make 12.
variation: For a bolder flavor, replace the pecans with chopped hazelnuts and Brie with blue cheese, such as Cambozola.

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Sunday, 3 August 2014

Obesity Complication of Hyperlipidemia

Kyle J. Norton

Obesity is defined as a medical condition of excess body fat has accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.  

How to calculate your BMI index
BMI= weight (kg)/ height (m2)

Hyperlipidemia
is defined as a condition of High Levels of Cholesterol and Triglycerides of that can increase the risk of heart disease, stroke, and other health problems.

 How Obesity associates with Hyperlipidemia ( High Levels of Cholesterol and Triglycerides)
1. According to the abstract of "Influence of having a male twin on body mass index and risk for dyslipidemia in middle-aged and old women" by C Alexanderson, S Henningsson, P Lichtenstein, A Holmäng and E Eriksson, posted in International Journal of Obesity, researchers concluded that The results support the notion that comparisons of women with a twin brother with women from same-sexed twin pairs may be used to shed light on possible long-term effects of interindividual variations in early androgen exposure, and (ii) suggest that the effects of early androgen exposure on metabolism previously observed in animal experiments are of relevance also for humans.

2. In the abstract of the study of "Plasma sterol evidence for decreased absorption and increased synthesis of cholesterol in insulin resistance and obesity" by Paramsothy P, Knopp RH, Kahn SE, Retzlaff BM, Fish B, Ma L, Ostlund RE Jr., posted in PubMed, researchers concluded that Cholesterol absorption was highest in the LIS participants, whereas cholesterol synthesis was highest in the LIR and OIR participants. Therapeutic diets for hyperlipidemia should emphasize low-cholesterol diets in LIS persons and weight loss to improve S(I) and to decrease cholesterol overproduction in LIR and OIR persons.

3. According to the study of "Obesity and dyslipidemia" by Repas T., posted in PubMed, researchers wrote in abstract that Dyslipidemia is frequently found in association with obesity. Obesity-related dyslipidemia is characterized by elevated triglycerides, elevated VLDL, increased apo-B, decreased HDL cholesterol and increased small dense LDL particles. This combination of lipid abnormalities is particularly atherogenic and, along with related comorbidities, explains the increased cardiovascular risk seen in obesity. Weight loss, through diet, medication and/or surgery all result in beneficial effects upon serum lipids. Dietary modification and lifestyle change are essential components in the management of obesity-related dyslipidemia. Many patients, however, require pharmacotherapy to achieve lipid goals.

4. In the study of "Prevalences of overweight, obesity, hyperglycaemia, hypertension and dyslipidaemia in the Gulf: systematic review" by Alhyas L, McKay A, Balasanthiran A, Majeed A., posted in PubMed, researchers found that there are high prevalences of risk factors for diabetes and diabetic complications in the GCC region, indicative that their current management is suboptimal. Enhanced management will be critical if escalation of diabetes-related problems is to be averted as industrialization, urbanization and changing population demographics continue.

5. In the abstract of "The relative risks of hyperglycaemia, obesity and dyslipidaemia in the relatives of patients with Type II diabetes mellitus" by Shaw JT, Purdie DM, Neil HA, Levy JC, Turner RC., posted in PubMed, researchers found that the relatives were significantly more obese, had higher fasting plasma insulin concentrations and had lower HDL-cholesterol concentrations. In conclusion, there is a strong familial aggregation of hyperglycaemia and obesity in the relatives of subjects with Type II diabetes and these subjects have higher fasting plasma insulin concentrations and lower HDL-cholesterol than the general population. These data indicate the particular relevance of screening the first degree relatives of subjects with Type II diabetes, as intervention strategies which aim to improve the metabolic profile are indicated for a large proportion of these subjects.

6. Etc.

Treatments of Obesity and Hyperlipidemia
1. According to the study of "Caloric restriction, aerobic exercise training and soluble lectin-like oxidized LDL receptor-1 levels in overweight and obese post-menopausal women" by T E Brinkley, X Wang, N Kume, H Mitsuoka and B J Nicklas, posted in International Journals of Obesity, researchers wrote that Weight loss interventions of equal energy deficit have similar effects on sLOX-1 levels in overweight and obese post-menopausal women, with the addition of aerobic exercise having no added benefit when performed in conjunction with CR.

2. In the abstract of the study of "Obesity, hyperlipidemia, and metabolic syndrome" by Charlton M., posted in PubMed, researchers wrote that in 4. It is rare for dietary changes and weight reduction to result in normalization of the lipid profile. Statins should thus be initiated early in the course of management of post-LT dyslipidemia. Forty milligrams of simvastatin per day, 40 mg of atorvastatin per day, and 20 mg of pravastatin per day are reasonable starting doses for post-LT hypercholesterolemia. It is important to remember that the effects of statin therapy are additive to those of a controlled diet (eg, a Mediterranean diet rich in omega-3 fatty acids, fruits, vegetables, and dietary fiber).

3. According to the study of "Group 1B phospholipase A2 deficiency protects against diet-induced hyperlipidemia in mice" by Hollie NI, Hui DY., posted in PubMed, researchers found that in addition to dietary fatty acids, gut-derived lysophospholipids derived from Pla2g1b hydrolysis of dietary and biliary phospholipids also promote hepatic VLDL production. Thus, the inhibition of lysophospholipid absorption via Pla2g1b inactivation may prove beneficial against diet-induced hyperlipidemia in addition to the protection against obesity and diabetes.

4. Etc.


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