The health effects of Vitamin A in Endometriosis

By Kyle J. Norton

During the last stage of the menstrual cycle, normally a layer of endometriosis lining on the inside of the uterus is expelled, known as menstruation blood, instead some of the endometriosis tissues grow somewhere in the body to cause endometriosis. Endometriosis also react to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through menstrual period.
A. Vitamin A
I. Definition
Vitamin A is a bi-polar molecule formed by bonds between carbon and hydrogen. It is a fat soluble vitamin. This means it can not be stored in the liver but it can be converted from beta-carotene, a powerful antioxidant. Besides helping in treating endometriosis, it is also known to have strong effects in improving vision and enhancing bone growth.
II. The health effects
1. Vitamin A is a very powerful antioxidant that not only helps to strengthen the immune system, but also protects against the growth of endometriosis, according to the University of California, The combination of Simvastatin and Retinoic acid (RA), showed that Simvastatin potentiated an inhibitory effect of RA on growth of human endometrial stromal (HES) cells(1), probably through  suppressing interleukin-6 production in human endometrial cells(5).

2. Vitamin A helps in regulating the gene expression by fighting against the forming of free radicals and protecting the body organs from abnormal growth of endometrial implants and adhesion, according to the Feinberg School of Medicine at Northwestern, endometriotic stromal cells, cause decreased expression of these genes of that leads to decreased retinol uptake and dominant FABP5-mediated prosurvival activity(2).

3. Vitamin A working together with other antioxidants as well as functioning of protein synthesis and fatty acid metabolism reduced oxidative stress which is a component of the inflammatory reaction associated with endometriosis(4), according to Université Catholique de Louvain(3).

4. Iron is necessary for production of red blood cells that carry oxygen in the blood stream for the body's cells(7). Women who have endometriosis with heavy blood loss during menstruation normally have iron deficiency because of loss of iron which is far greater than what the body can produce leading to anemia(8). S-ferritin levels were inversely correlated with the duration of menstrual bleeding. Intake of vitamin A and iron will increase the production of red blood cells far better than taking iron supplements alone(9).
Remember, overloading on zinc or iron is toxic to our body and may induce endometriosis(6). Please make sure to talk to your doctor for the correct amount.

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References
(1) Effects of simvastatin on retinoic acid system in primary human endometrial stromal cells and in a chimeric model of human endometriosis by Sokalska A¹, Anderson M, Villanueva J, Ortega I, Bruner-Tran KL, Osteen KG, Duleba AJ.(PubMed)
(2) Altered retinoid uptake and action contributes to cell survival in endometriosis by Pavone ME¹, Reierstad S, Sun H, Milad M, Bulun SE, Cheng YH.(PubMed)
(3) Oxidative stress and peritoneal endometriosis by Van Langendonckt A¹, Casanas-Roux F, Donnez J.(PubMed)
(4) Women with endometriosis improved their peripheral antioxidant markers after the application of a high antioxidant diet by Mier-Cabrera J¹, Aburto-Soto T, Burrola-Méndez S, Jiménez-Zamudio L, Tolentino MC, Casanueva E, Hernández-Guerrero C.(PubMed)
(5) Retinoic acid suppresses interleukin-6 production in human endometrial cells by Sawatsri S¹, Desai N, Rock JA, Sidell N.(PubMed)
(6) The role of iron in the pathogenesis of endometriosis by Kobayashi H¹, Yamada Y, Kanayama S, Furukawa N, Noguchi T, Haruta S, Yoshida S, Sakata M, Sado T, Oi H.(PubMed)
(7) Insights into iron and nuclear factor-kappa B (NF-kappaB) involvement in chronic inflammatory processes in peritoneal endometriosis by Defrère S¹, González-Ramos R, Lousse JC, Colette S, Donnez O, Donnez J, Van Langendonckt A.(PubMed)
(8) Iron status in 268 Danish women aged 18-30 years: influence of menstruation, contraceptive method, and iron supplementation by bMilman N¹, Clausen J, Byg KE.(PubMed|)
(9) Iron deficiency and anemia are associated with low retinol levels in children aged 1 to 5 years by Saraiva BC¹, Soares MC¹, Santos LC¹, Pereira SC¹, Horta PM².(PubMed)

Fried rice with Anchovies and cilantro

Recipe attributed to 125 best  Chinese recipes by Bill Jones and Stephen Wong, published by Robert Rose

1 tbsp. vegetable oil  15mL
4  oil-packed anchovy fillets   4
1tbsp. minced ginger root  15mL
3 cups cooked rice 750mL
1tbsp. chicken stock  15mL
1/4 cup finely chopped cilantro  50mL
salt and pepper to taste
1. In a non stick wok or skillet, heat oil over medium heat. Add anchovies and ginger root; fry until fragrant, about 30 second.
2 Add rice and stir fry until the anchovy mixture is thoroughly integrated and the grains are separate, about 2 minutes, Add chicken stock; stir and cook until rice is heated through, about 1 minute. (Add more chicken stock if rice appears too dry). Add cilantro, stir to combine. Season with salt and pepper; stir to mix. Serve immediately. Make 4 serving.

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Peach pie salad

Recipes attributed to Company Coming salad by Jean Pare

An unusual way to begin a salad. It is so good
Peach pie filling  19 Oz. 540 mL
Pineapple tidbits, drained  14 Oz.  398L
Fruit cocktail, grained  14 Oz. 398 mL
Bananas, sliced  2
Seedless green grapes  1cup, 250 mL
Small marshmallows  1 cup, 250 mL
Put pie filling into bowl. Stir in drained pineapple and fruit cocktail. Add sliced bananas. Add grapes and marshmallows. Stir together. Turn into a pretty serving bowl and chill several hours bedsore serving. Serve 15.

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How to get Free Traffic to Your Websites

By Kyle J. Norton

With the competitiveness of online business, driving traffic to your website now becomes a life or death matter. Some people may opt to pay for search engines to expose their site, if you do it is good if you can do it properly. Otherwise, they may be costly. Many inexperienced new online advertisers go broke because of that. While putting your ads on some search engines are expensive and time consuming, you can get free traffic by writing some good articles about your site, the products which you sale and have other webmasters reprint your article. Be careful, your article has to be unique and honest, and your products should perform as you said or better. Otherwise, it may produce opposite effects.
Remember if you have written 10 articles and submitted them to 180 article directories with 20 viewer a day for each directories, here is the numbers of visitor your site has in a year
Total real visitors in a year 13,140,000= 10x365x180x20
Everyday your site has been visited by 36,000 visitors
1. Submit to article directories
There are many reputable article sites which will publish your article free. You should consider some with high ranking article submitter sites, because it helps to:
a) Increase your site worthiness
b) Increase your site ranking and boost your Alexa ranking.
c) Increase traffic to your site. Most article published on these sites will be reprinted by other webmasters with your name and link intact.
d) Add more one way link to your website.
e) Spread your web links throughout the internet and generate even more traffic, back link, and page rank.
2. Submit as many article directories as possible
In this way, your site will get free links to many other article sites. Since each article directory has it's own audiences, your site will gain a lot more traffic if you submit your article only to some sites.
3. Link to your website
Never put your links in the article, because most people think links in the web page are some kind of advertisement. You should make your link embedded into some keyword in your resource box or at the end of the article. It is always effective to make people clicking it.
4. Make yourself outstanding
Always allow your clients to vote for your services or products which you provide. In this way your client will gain confidence to deal with you because of all those good comments from other people who have bought your services or products. Remember, it takes more than 5 good comments to make even for one bad comment. So be honest to your client, it is the best way to do it. If your products or your services are good, your clients will come back.
5. Refund and support
There are always some refunds if you are selling services or products online. Remember to refund your client's money quickly to gain your reputability even with an unreasonable reason. In this way, you can gain some of your clients' confidence to deal with you. If you receive questions from your clients, you should write to them as soon as possible to gain credibility.
6. Use auto submitter
In this way, you can save time and have your article exposed to hundreds of thousands of article directories with one click of the mouse. Remember, article submitting to hundreds of directories by hand is time consuming.
7. Choose the good auto article submitter and have at least 8 weeks refund guaranteed
There are many auto article submitters around, but only a few are good. You should consider only ones with constant updates, having at least 150 article directories with at least 8 weeks refund guarantee.
For the Best 3 Article Submitters Review
http://articlesubmittersreview.blogspot.com/

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Cinnamon Goji Cream Smoothies

This smoothie is a sinfully sweet blend of nutritious Goji berries, tropical coconut and warming cinnamon. Enjoy it on cooler days when you are craving something rich and satisfying.
Tips:
Goji berries are small native to China and Tibet. They have a mildly sweet favor and are great addition to smoothie. You can find them in natural foods store and most well stocked grocery store.
Coconut oils is solid in room temperature. it has a melting temperature of 76 degree F (24 degree C), so it is easy to liquefy. To melt it, place in a shallow glass bowl over a pot of simmering water
 1 cup nut milk  250mL
1 banana   1
1/4 cup goji berries 60mL
2tbsp. melted coconut oil 30mL
1/4 tsp. ground cinnamon
In a blender, combine nut milk, banana, goji berries, coconut oil and cinnamon. Blend at high speed until smooth. Serve immediately. Make1/12 cups (375mL).
Variation Chocolate Goji cream smoothie: Substitute 2 tbsp. (30mL) raw cacao powder for cinnamon and add 1 - tbsp. (15 - 30mL) raw agave nectar depending on desired sweetness.
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The Most healthy Fruit snack

Recipes attributed to Company Coming salad by Jean Pare

This is the thing when appetites call for something light. Make it right from the shell, add toast or muffins and your snack is complete.
Pineapple, chunks, drained, reserve juice  14 Oz. 398 mL
Canned Mandari9n oranges, drained 10 Oz. 284 mL
Bananas sliced 2
Combine pineapple, orange and banana together in bowl. Spoon on a bit of the pineapple juice or serve it separate container. Serve 2 - 3.
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Phytochemical Indole-3-carbinol and Prostate cancer

 By Kyle J. Norton

Indole-3-carbinol is a phytochemical in the class of Indoles, by the breaking down of the glucosinolate glucobrassicin, found abundantly in cabbage, kale, Brussels sprouts, rutabaga, mustard greens, broccoli, etc.

Prostate cancer is defined as a condition in which the cells of prostate has become cancerous, causing abnormal cell growth which spread to the distant parts of the body. Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.

Indole-3-carbinol, has showed a strong evidence in supporting the use of  phytochemicals as epigenetic modulators for prostate cancer chemoprevention(1). Indole-3-carbinol (I3C), a common phytochemical in cruciferous vegetables, inhibited prostate cancer through induced G1 cell-cycle arrest and apoptosis in prostate cancer cells(2). In human PC-3 prostate cancer cell lines, the phytochemical also induced G1 cell cycle arrest of that leading to apoptosis, and regulates the expression of apoptosis-related genes(3). According to the Division of Cancer Prevention, National Cancer Institute, broccoli-derived compounds indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM), showed to inhibit prostate cancer through modulation of the effect of androgen on CCL2-mediated pathways(4).

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references

(1) Phytochemicals from cruciferous vegetables, epigenetics, and prostate cancer prevention. by W Watson G¹, M Beaver L, E Williams D, H Dashwood R, Ho E.(PubMed)

(2) Indole-3-carbinol and prostate cancer by Sarkar FH¹, Li Y.(PubMed)

(3) Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells by Chinni SR¹, Li Y, Upadhyay S, Koppolu PK, Sarkar FH.(PubMed)

(4) Indole-3-carbinol and 3',3'-diindolylmethane modulate androgen's effect on C-C chemokine ligand 2 and monocyte attraction to prostate cancer cells by Kim EK¹, Kim YS, Milner JA, Wang TT.(PubMed)