Recipes attributed to Company Coming salad by Jean Pare
The most simple way to serve cottage cheese and still make it attractive. No limit. More of an idea than a recipe.
Cottage cheese
Paprika
Fill a pretty bowl with cottage cheese. Sprinkle with paprika. Serve.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to 1000 free AND HEALTHY recipes and counting
http://kylejnorton.blogspot.ca/p/recipes.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Weight Loss the Easy Ways
Andrea Albright Featured on Health and Fitness Jan. 2015
will Personally Coach You How to Get There The Easy Way
If You Are Looking For a SoulMate
Celebrity Patti Stanger Will Coach You To Get Him/Her
and Keep Him/Her for Good,The Simple Way
Friday, 11 July 2014
Thursday, 10 July 2014
Herbal therapy - Chaste tree berry (Vitex agnus-castus)
By Kyle J. Norton
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region. It has been used in herbal medicine for thousands of year as anaphrodisiac herb and is considered as Queen herb in treating menstrual problems and discomforts by taking it in a prolonged period of time. There was report that reports chaste tree berry stems and leaves used by women as bedding "to cool the heat of lust" during the time of the Thesmophoria,
Chemical constituents
1. β-citronellol
2. Labdane-type diterpenoids,
3. Halimane-type diterpenoid,
4. Oleanane-type triterpenoids,
5. Ursane-type triterpenoids,
6. Sesquiterpenoid,
7. Flavonoid
8. Viteagnusins C, D, E, F, G, and H
9. Abietane-type diterpenoids
Health Benefits
1. Chaste tree berry and premenstrual syndrome (PMS)
Premenstrual syndrome effects over 70% to 90% of women in the US and less for women in Southeast Asia because of their difference in living style and social structure. It is defined as faulty function of the ovaries related to the women's menstrual cycle, it effects a women's physical and emotional state, and sometimes interferes with daily activities as a result of hormone fluctuation. The syndrome occurs one to two weeks before menstruation and then declines when the period starts.
A double-blind, randomized, placebo-controlled parallel trial was conducted over 16 weeks on menopause-related symptoms with combination of Hypericum perforatum (St. John's wort) and Vitex agnus-castus (chaste tree/berry), showed a superior effect of the combination when compare to placebo in total PMS-like scores (p = 0.02), PMS-D (p = 0.006), and PMS-C clusters (p = 0.027). significant reductions in the anxiety (p = 0.003) and hydration (p = 0.002) clusters and suggested that the combination may be a potentially significant clinical application for this phytotherapeutic combination in PMS-like symptoms among perimenopausal women(1). The preliminary data of Technion-Israel Institute of Technology also support the efficacy of Chaste tree fruit (Vitex agnus) in the treatment of PMS(2). In a 1634 patients suffering from premenstrual syndrome (PMS), to test fpr the effects of Vitex on psychic and somatic complaints, on the four characteristic PMS symptom complexes depression, anxiety, craving, and hyperhydration (DACH), and on single groups of symptoms, indicated that Vitex treatment period of three menstrual cycles 93% of patients reported a decrease in the number of symptoms or even cessation of PMS complaints(3).
References
(1) Effects of a combination of Hypericum perforatum and Vitex agnus-castus on PMS-like symptoms in late-perimenopausal women: findings from a subpopulation analysis by van Die MD1, Bone KM, Burger HG, Reece JE, Teede HJ.(PubMed)
(2) [Herbal medicine in womens' life cycle].[Article in Hebrew] by Ben-Arye E1, Oren A, Ben-Arie A.(PubMed)
(3) Treatment of premenstrual syndrome with a phytopharmaceutical formulation containing Vitex agnus castus by Loch EG1, Selle H, Boblitz N.(PubMed)
2. Chaste tree berry (Vitex agnus-castus) and leukaemia
Leukemia is defined as condition of abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system. Depending to the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.
Bone marrow is soft tissue inside the hollow center of major bone. including spine, pelvis, under arm, leg. etc.
Chaste tree berry may process an anti leukaemia effect. According to the Tokyo University of Pharmacy and Life Sciences, Chaste tree berry extract inhibited HL60 liver cancer cell line through Vitex induced a dose- and time-dependent decrease in cell viability associated with induction of apoptosis and G2/M cell cycle arrest in a a dose- and time-dependent manner(1). Also on leukemia cell lines, HL-60 and U-937, extract from the ripe fruit of Vitex agnus-castus (Vitex), inhibited both cell lines through its cytotoxicity activity in dose depend manner(2).
References
(1) Involvement of histone H3 phosphorylation via the activation of p38 MAPK pathway and intracellular redox status in cytotoxicity of HL-60 cells induced by Vitex agnus-castus fruit extract by chi H1, Yuan B1, Yuhara E1, Imai M1, Furutani R1, Fukushima S1, Hazama S1, Hirobe C2, Ohyama K1, Takagi N3, Toyoda H1.(PubMed)
(2) Cytotoxicity of Vitex agnus-castus fruit extract and its major component, casticin, correlates with differentiation status in leukemia cell lines by chi H1, Yuan B, Nishimura Y, Imai M, Furutani R, Kamoi S, Seno M, Fukushima S, Hazama S, Hirobe C, Ohyama K, Hu XM, Takagi N, Hirano T, Toyoda H.(PubMed)
3. Chaste tree berry (Vitex agnus-castus) and anticancer effects
Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.
In human uterine cervical canal fibroblast (HCF), human embryo fibroblast (HE-21), ovarian cancer (MCF-7), cervical carcinoma (SKG-3a), breast carcinoma (SKOV-3), gastric signet ring carcinoma (KATO-III), colon carcinoma (COLO 201), and small cell lung carcinoma (Lu-134-A-H) cells, crude extract prepared with ethanol from dried ripened Vitex agnus-castus fruits, inhibited SKOV-3, KATO-III, COLO 201, and Lu-134-A-H cell lines through its cytotoxic activity and apoptosis(1).
In a human gastric signet ring carcinoma cell line, KATO-III, according to Tokyo University of Pharmacy and Life Science, ethanol extract of the dried ripe fruit of Vitex agnus-castus (Vitex) also displayed cytotoxic activity through intracellular oxidative stress and mitochondrial membrane damage(2). In prostate epithelial cell lines (BPH-1, LNCaP, PC-3), the Extracts of Vitex agnus-castus fruits (VACF), inhibited proliferation and induced apoptosis in a concentration-dependent manner(3).
References
(1) Cytotoxicity and apoptotic inducibility of Vitex agnus-castus fruit extract in cultured human normal and cancer cells and effect on growth by Ohyama K1, Akaike T, Hirobe C, Yamakawa T.(PubMed)
(2) Human gastric signet ring carcinoma (KATO-III) cell apoptosis induced by Vitex agnus-castus fruit extract through intracellular oxidative stress by Ohyama K1, Akaike T, Imai M, Toyoda H, Hirobe C, Bessho T.(PubMed)
(3) A Vitex agnus-castus extract inhibits cell growth and induces apoptosis in prostate epithelial cell lines by Weisskopf M1, Schaffner W, Jundt G, Sulser T, Wyler S, Tullberg-Reinert H.(PubMed)
4. Chaste tree berry (Vitex agnus-castus) and Menopausal symptoms
Menopause is the defined as a condition in which a woman is in the transition stage of permanent cessation of the ovaries functions in egg production because of less production of estrogen and progesterone, signalling the end of the reproductive phrase a woman's life. In menopause, menstruation has become irregular and slowly stop overtime, but in some women, menstrual flow comes to a sudden halt.
In a self-administered questionnaire, containing 15 questions, sent to all gynecologists in private practice in Germany to evaluate the complementary and alternative medicine (CAM) in the treatment of climacteric disorders, 98% of the returnees are experience with therapies of black cohosh (Cimicifuga racemosa), chaste tree (Vitex agnus castus) and St. John's wort(1). According to the 1Royal Melbourne Institute of Technology (RMIT) University, Bundoora, although evidence from rigorous randomized controlled trials is lacking for the individual herb emerging pharmacological evidence supports a role for V. agnus-castus in the alleviation of menopausal symptoms(2). Dr. Chopin Lucks B. in the trial of two essential oils (derived separately from leaf and fruit) of Vitex agnus castus indicated that both essential oil shows a strong symptomatic relief of common menopausal symptoms(3).
Unfortunately, according to the University Hospital Hamburg-Eppendorf, Agnus castus showed no significant difference in the treatment of climacteric complaints(4) with a combination of Hypericum perforatum (St. John's wort) and Vitex agnus-castus (Chaste tree/berry) also showed the same(5).
References
(1) The value of complementary and alternative medicine in the treatment of climacteric symptoms: results of a survey among German gynecologists by von Studnitz FS1, Eulenburg C, Mueck AO, Buhling KJ.(PubMed)
(2) Vitex agnus-castus (Chaste-Tree/Berry) in the treatment of menopause-related complaints by van Die MD1, Burger HG, Teede HJ, Bone KM.(PubMed)
(3) Vitex agnus castus essential oil and menopausal balance: a research update [Complementary Therapies in Nursing and Midwifery 8 (2003) 148-154] by Chopin Lucks B.(PubMed)
(4) Efficacy of Cimicifuga racemosa, Hypericum perforatum and Agnus castus in the treatment of climacteric complaints: a systematic review by Laakmann E1, Grajecki D, Doege K, zu Eulenburg C, Buhling KJ.(PubMed)
(5) Hypericum perforatum with Vitex agnus-castus in menopausal symptoms: a randomized, controlled trial by van Die MD1, Burger HG, Bone KM, Cohen MM, Teede HJ.(PubMed)
5. Chaste tree berry (Vitex agnus-castus) and Hyperprolactinaemia
Hyperproclinaemia is a condition with levels of prolactin in the blood that may disrupt the normal menstrual period in women.
Vitex agnus-castus L. (chaste tree; chasteberry) has long been sued in herbal medicine for treatment, predominantly in wide range of female reproductive conditions. According to the 1Royal Melbourne Institute of Technology-University, Bundoora, there are some reports of the herb in reducing TRH-stimulated prolactin secretion, normalising a shortened luteal phase, increasing mid-luteal progesterone and 17β-oestradiol levels of which comparable to bromocriptine for reducing serum prolactin levels and ameliorating cyclic mastalgia(1). The study in monitoring the prolactin release 15 and 30 min after i.v. injection of 200 micrograms TRH. 37 complete case reports (placebo: n = 20, verum: n = 17) after 3 month of therapy, indicated that the herb did not change with the exception of 17 beta-estradiol which rouse up in the luteal phase in patients receiving verum with no adverse effect(2).
References
(1) Vitex agnus-castus extracts for female reproductive disorders: a systematic review of clinical trials by van Die MD1, Burger HG, Teede HJ, Bone KM.(PubMed)
(2) [Vitex agnus castus extract in the treatment of luteal phase defects due to latent hyperprolactinemia. Results of a randomized placebo-controlled double-blind study].[Article in German] by Milewicz A1, Gejdel E, Sworen H, Sienkiewicz K, Jedrzejak J, Teucher T, Schmitz H.(PubMed)
6. Chaste tree berry (Vitex agnus-castus) and Mastalgia
Mastalgia is a condition of breast tenderness and pain come and gone with monthly periods.
Vitex agnus castus (VACS) extract in treatment phase lasted 3 consequent menstrual cycles (2 x 30 drops/day = 1.8 ml of VASC) or placebo in a double-blind, placebo controlled in two parallel groups (each 50 patients), showed to inbibit cyclical breast pain in women(1). In support to the view, the study of Gynecology: select topics, indicated that chaste tree may attenuate the symptoms of mastalgia(2) such as premenstrual mastodynia(Breast pain)(3).
References
(1) [Treatment of cyclical mastodynia using an extract of Vitex agnus castus: results of a double-blind comparison with a placebo].[Article in Czech by Halaska M1, Raus K, Bĕles P, Martan A, Paithner KG.(PubMed)
(2) Gynecology: select topics by Sidani M1, Campbell J.(PubMed)
(3) Chaste tree (Vitex agnus-castus)--pharmacology and clinical indications by Wuttke W1, Jarry H, Christoffel V, Spengler B, Seidlová-Wuttke D.(PubMed)
7. Chaste tree berry (Vitex agnus-castus) and Propionibacterium acnes
Propionibacterium acnes is a type of acne dur to infection of aerotolerant anaerobic, Gram-positive bacterium (rod) or as a result of chronic blepharitis and endophthalmitis.
Vitex agnus-castus has long been used for treatment of hormonally induced acne in herbal medicine(1) with mild or no adverse side effect(2). Vitex negundo, a five-leaved chaste tree extract, according to the study by the The Institute of Science, India, showed a significant inhibition of lipase activity and number of P. acnes(1).
References
(1) The genus Vitex: A review by Rani A1, Sharma A2.(PubMed)
(2) Vitex agnus castus: a systematic review of adverse events by Daniele C1, Thompson Coon J, Pittler MH, Ernst E.(PubMed)
(3) Inhibition of Propionibacterium acnes lipase by extracts of Indian medicinal plants by Patil V1, Bandivadekar A, Debjani D.(PubMed)
8. Chaste tree berry (Vitex agnus-castus) and oligomenorrhea and Amenorrhea
Oligomenorrhea is an irregular menstruation and defined as a condition of infrequent period or a woman menstrual period does not occur at a interval of greater than 35 days.
Amenorrhea is defined as a health condition of absence of period.
In a study of 37 women with oligomenorrhea and 30 women with amenorrhea received 50 drops of Phyto Hypophyson , a an Agnus castus-containing homeopathic preparation, or placebo 3 times a day over 3 months or 3 cycles, conducted by Universitäts-Frauenklinik, suggested that women with sterility and oligomenorrhea, a treatment with Phyto Hypophyson L can be recommended over a period of 3-6 months(1). Dr. Veal L. suggested that Vitex agnus-castus, or a blend of essential oils designed to treat amenorrhoea or scanty/irregular periods(2).
References
(1) [The efficacy of the complex medication Phyto-Hypophyson L in female, hormone-related sterility. A randomized, placebo-controlled clinical double-blind study].[Article in German] by Bergmann J1, Luft B, Boehmann S, Runnebaum B, Gerhard I.(PubMed)
(2) Complementary therapy and infertility: an Icelandic perspective by Veal L.(PubMed)
Weight Loss the Easy Ways
Andrea Albright Featured on Health and Fitness Jan. 2015
will Personally Coach You How to Get There The Easy Way
If You Are Looking For a SoulMate
Celebrity Patti Stanger Will Coach You To Get Him/Her
and Keep Him/Her for Good,The Simple Way
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to 1000 free AND HEALTHY recipes and counting
http://kylejnorton.blogspot.ca/p/recipes.html
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region. It has been used in herbal medicine for thousands of year as anaphrodisiac herb and is considered as Queen herb in treating menstrual problems and discomforts by taking it in a prolonged period of time. There was report that reports chaste tree berry stems and leaves used by women as bedding "to cool the heat of lust" during the time of the Thesmophoria,
Chemical constituents
1. β-citronellol
2. Labdane-type diterpenoids,
3. Halimane-type diterpenoid,
4. Oleanane-type triterpenoids,
5. Ursane-type triterpenoids,
6. Sesquiterpenoid,
7. Flavonoid
8. Viteagnusins C, D, E, F, G, and H
9. Abietane-type diterpenoids
Health Benefits
1. Chaste tree berry and premenstrual syndrome (PMS)
Premenstrual syndrome effects over 70% to 90% of women in the US and less for women in Southeast Asia because of their difference in living style and social structure. It is defined as faulty function of the ovaries related to the women's menstrual cycle, it effects a women's physical and emotional state, and sometimes interferes with daily activities as a result of hormone fluctuation. The syndrome occurs one to two weeks before menstruation and then declines when the period starts.
A double-blind, randomized, placebo-controlled parallel trial was conducted over 16 weeks on menopause-related symptoms with combination of Hypericum perforatum (St. John's wort) and Vitex agnus-castus (chaste tree/berry), showed a superior effect of the combination when compare to placebo in total PMS-like scores (p = 0.02), PMS-D (p = 0.006), and PMS-C clusters (p = 0.027). significant reductions in the anxiety (p = 0.003) and hydration (p = 0.002) clusters and suggested that the combination may be a potentially significant clinical application for this phytotherapeutic combination in PMS-like symptoms among perimenopausal women(1). The preliminary data of Technion-Israel Institute of Technology also support the efficacy of Chaste tree fruit (Vitex agnus) in the treatment of PMS(2). In a 1634 patients suffering from premenstrual syndrome (PMS), to test fpr the effects of Vitex on psychic and somatic complaints, on the four characteristic PMS symptom complexes depression, anxiety, craving, and hyperhydration (DACH), and on single groups of symptoms, indicated that Vitex treatment period of three menstrual cycles 93% of patients reported a decrease in the number of symptoms or even cessation of PMS complaints(3).
References
(1) Effects of a combination of Hypericum perforatum and Vitex agnus-castus on PMS-like symptoms in late-perimenopausal women: findings from a subpopulation analysis by van Die MD1, Bone KM, Burger HG, Reece JE, Teede HJ.(PubMed)
(2) [Herbal medicine in womens' life cycle].[Article in Hebrew] by Ben-Arye E1, Oren A, Ben-Arie A.(PubMed)
(3) Treatment of premenstrual syndrome with a phytopharmaceutical formulation containing Vitex agnus castus by Loch EG1, Selle H, Boblitz N.(PubMed)
2. Chaste tree berry (Vitex agnus-castus) and leukaemia
Leukemia is defined as condition of abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system. Depending to the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.
Bone marrow is soft tissue inside the hollow center of major bone. including spine, pelvis, under arm, leg. etc.
Chaste tree berry may process an anti leukaemia effect. According to the Tokyo University of Pharmacy and Life Sciences, Chaste tree berry extract inhibited HL60 liver cancer cell line through Vitex induced a dose- and time-dependent decrease in cell viability associated with induction of apoptosis and G2/M cell cycle arrest in a a dose- and time-dependent manner(1). Also on leukemia cell lines, HL-60 and U-937, extract from the ripe fruit of Vitex agnus-castus (Vitex), inhibited both cell lines through its cytotoxicity activity in dose depend manner(2).
References
(1) Involvement of histone H3 phosphorylation via the activation of p38 MAPK pathway and intracellular redox status in cytotoxicity of HL-60 cells induced by Vitex agnus-castus fruit extract by chi H1, Yuan B1, Yuhara E1, Imai M1, Furutani R1, Fukushima S1, Hazama S1, Hirobe C2, Ohyama K1, Takagi N3, Toyoda H1.(PubMed)
(2) Cytotoxicity of Vitex agnus-castus fruit extract and its major component, casticin, correlates with differentiation status in leukemia cell lines by chi H1, Yuan B, Nishimura Y, Imai M, Furutani R, Kamoi S, Seno M, Fukushima S, Hazama S, Hirobe C, Ohyama K, Hu XM, Takagi N, Hirano T, Toyoda H.(PubMed)
3. Chaste tree berry (Vitex agnus-castus) and anticancer effects
Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.
In human uterine cervical canal fibroblast (HCF), human embryo fibroblast (HE-21), ovarian cancer (MCF-7), cervical carcinoma (SKG-3a), breast carcinoma (SKOV-3), gastric signet ring carcinoma (KATO-III), colon carcinoma (COLO 201), and small cell lung carcinoma (Lu-134-A-H) cells, crude extract prepared with ethanol from dried ripened Vitex agnus-castus fruits, inhibited SKOV-3, KATO-III, COLO 201, and Lu-134-A-H cell lines through its cytotoxic activity and apoptosis(1).
In a human gastric signet ring carcinoma cell line, KATO-III, according to Tokyo University of Pharmacy and Life Science, ethanol extract of the dried ripe fruit of Vitex agnus-castus (Vitex) also displayed cytotoxic activity through intracellular oxidative stress and mitochondrial membrane damage(2). In prostate epithelial cell lines (BPH-1, LNCaP, PC-3), the Extracts of Vitex agnus-castus fruits (VACF), inhibited proliferation and induced apoptosis in a concentration-dependent manner(3).
References
(1) Cytotoxicity and apoptotic inducibility of Vitex agnus-castus fruit extract in cultured human normal and cancer cells and effect on growth by Ohyama K1, Akaike T, Hirobe C, Yamakawa T.(PubMed)
(2) Human gastric signet ring carcinoma (KATO-III) cell apoptosis induced by Vitex agnus-castus fruit extract through intracellular oxidative stress by Ohyama K1, Akaike T, Imai M, Toyoda H, Hirobe C, Bessho T.(PubMed)
(3) A Vitex agnus-castus extract inhibits cell growth and induces apoptosis in prostate epithelial cell lines by Weisskopf M1, Schaffner W, Jundt G, Sulser T, Wyler S, Tullberg-Reinert H.(PubMed)
4. Chaste tree berry (Vitex agnus-castus) and Menopausal symptoms
Menopause is the defined as a condition in which a woman is in the transition stage of permanent cessation of the ovaries functions in egg production because of less production of estrogen and progesterone, signalling the end of the reproductive phrase a woman's life. In menopause, menstruation has become irregular and slowly stop overtime, but in some women, menstrual flow comes to a sudden halt.
In a self-administered questionnaire, containing 15 questions, sent to all gynecologists in private practice in Germany to evaluate the complementary and alternative medicine (CAM) in the treatment of climacteric disorders, 98% of the returnees are experience with therapies of black cohosh (Cimicifuga racemosa), chaste tree (Vitex agnus castus) and St. John's wort(1). According to the 1Royal Melbourne Institute of Technology (RMIT) University, Bundoora, although evidence from rigorous randomized controlled trials is lacking for the individual herb emerging pharmacological evidence supports a role for V. agnus-castus in the alleviation of menopausal symptoms(2). Dr. Chopin Lucks B. in the trial of two essential oils (derived separately from leaf and fruit) of Vitex agnus castus indicated that both essential oil shows a strong symptomatic relief of common menopausal symptoms(3).
Unfortunately, according to the University Hospital Hamburg-Eppendorf, Agnus castus showed no significant difference in the treatment of climacteric complaints(4) with a combination of Hypericum perforatum (St. John's wort) and Vitex agnus-castus (Chaste tree/berry) also showed the same(5).
References
(1) The value of complementary and alternative medicine in the treatment of climacteric symptoms: results of a survey among German gynecologists by von Studnitz FS1, Eulenburg C, Mueck AO, Buhling KJ.(PubMed)
(2) Vitex agnus-castus (Chaste-Tree/Berry) in the treatment of menopause-related complaints by van Die MD1, Burger HG, Teede HJ, Bone KM.(PubMed)
(3) Vitex agnus castus essential oil and menopausal balance: a research update [Complementary Therapies in Nursing and Midwifery 8 (2003) 148-154] by Chopin Lucks B.(PubMed)
(4) Efficacy of Cimicifuga racemosa, Hypericum perforatum and Agnus castus in the treatment of climacteric complaints: a systematic review by Laakmann E1, Grajecki D, Doege K, zu Eulenburg C, Buhling KJ.(PubMed)
(5) Hypericum perforatum with Vitex agnus-castus in menopausal symptoms: a randomized, controlled trial by van Die MD1, Burger HG, Bone KM, Cohen MM, Teede HJ.(PubMed)
5. Chaste tree berry (Vitex agnus-castus) and Hyperprolactinaemia
Hyperproclinaemia is a condition with levels of prolactin in the blood that may disrupt the normal menstrual period in women.
Vitex agnus-castus L. (chaste tree; chasteberry) has long been sued in herbal medicine for treatment, predominantly in wide range of female reproductive conditions. According to the 1Royal Melbourne Institute of Technology-University, Bundoora, there are some reports of the herb in reducing TRH-stimulated prolactin secretion, normalising a shortened luteal phase, increasing mid-luteal progesterone and 17β-oestradiol levels of which comparable to bromocriptine for reducing serum prolactin levels and ameliorating cyclic mastalgia(1). The study in monitoring the prolactin release 15 and 30 min after i.v. injection of 200 micrograms TRH. 37 complete case reports (placebo: n = 20, verum: n = 17) after 3 month of therapy, indicated that the herb did not change with the exception of 17 beta-estradiol which rouse up in the luteal phase in patients receiving verum with no adverse effect(2).
References
(1) Vitex agnus-castus extracts for female reproductive disorders: a systematic review of clinical trials by van Die MD1, Burger HG, Teede HJ, Bone KM.(PubMed)
(2) [Vitex agnus castus extract in the treatment of luteal phase defects due to latent hyperprolactinemia. Results of a randomized placebo-controlled double-blind study].[Article in German] by Milewicz A1, Gejdel E, Sworen H, Sienkiewicz K, Jedrzejak J, Teucher T, Schmitz H.(PubMed)
6. Chaste tree berry (Vitex agnus-castus) and Mastalgia
Mastalgia is a condition of breast tenderness and pain come and gone with monthly periods.
Vitex agnus castus (VACS) extract in treatment phase lasted 3 consequent menstrual cycles (2 x 30 drops/day = 1.8 ml of VASC) or placebo in a double-blind, placebo controlled in two parallel groups (each 50 patients), showed to inbibit cyclical breast pain in women(1). In support to the view, the study of Gynecology: select topics, indicated that chaste tree may attenuate the symptoms of mastalgia(2) such as premenstrual mastodynia(Breast pain)(3).
References
(1) [Treatment of cyclical mastodynia using an extract of Vitex agnus castus: results of a double-blind comparison with a placebo].[Article in Czech by Halaska M1, Raus K, Bĕles P, Martan A, Paithner KG.(PubMed)
(2) Gynecology: select topics by Sidani M1, Campbell J.(PubMed)
(3) Chaste tree (Vitex agnus-castus)--pharmacology and clinical indications by Wuttke W1, Jarry H, Christoffel V, Spengler B, Seidlová-Wuttke D.(PubMed)
7. Chaste tree berry (Vitex agnus-castus) and Propionibacterium acnes
Propionibacterium acnes is a type of acne dur to infection of aerotolerant anaerobic, Gram-positive bacterium (rod) or as a result of chronic blepharitis and endophthalmitis.
Vitex agnus-castus has long been used for treatment of hormonally induced acne in herbal medicine(1) with mild or no adverse side effect(2). Vitex negundo, a five-leaved chaste tree extract, according to the study by the The Institute of Science, India, showed a significant inhibition of lipase activity and number of P. acnes(1).
References
(1) The genus Vitex: A review by Rani A1, Sharma A2.(PubMed)
(2) Vitex agnus castus: a systematic review of adverse events by Daniele C1, Thompson Coon J, Pittler MH, Ernst E.(PubMed)
(3) Inhibition of Propionibacterium acnes lipase by extracts of Indian medicinal plants by Patil V1, Bandivadekar A, Debjani D.(PubMed)
8. Chaste tree berry (Vitex agnus-castus) and oligomenorrhea and Amenorrhea
Oligomenorrhea is an irregular menstruation and defined as a condition of infrequent period or a woman menstrual period does not occur at a interval of greater than 35 days.
Amenorrhea is defined as a health condition of absence of period.
In a study of 37 women with oligomenorrhea and 30 women with amenorrhea received 50 drops of Phyto Hypophyson , a an Agnus castus-containing homeopathic preparation, or placebo 3 times a day over 3 months or 3 cycles, conducted by Universitäts-Frauenklinik, suggested that women with sterility and oligomenorrhea, a treatment with Phyto Hypophyson L can be recommended over a period of 3-6 months(1). Dr. Veal L. suggested that Vitex agnus-castus, or a blend of essential oils designed to treat amenorrhoea or scanty/irregular periods(2).
References
(1) [The efficacy of the complex medication Phyto-Hypophyson L in female, hormone-related sterility. A randomized, placebo-controlled clinical double-blind study].[Article in German] by Bergmann J1, Luft B, Boehmann S, Runnebaum B, Gerhard I.(PubMed)
(2) Complementary therapy and infertility: an Icelandic perspective by Veal L.(PubMed)
Weight Loss the Easy Ways
Andrea Albright Featured on Health and Fitness Jan. 2015
will Personally Coach You How to Get There The Easy Way
If You Are Looking For a SoulMate
Celebrity Patti Stanger Will Coach You To Get Him/Her
and Keep Him/Her for Good,The Simple Way
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to 1000 free AND HEALTHY recipes and counting
http://kylejnorton.blogspot.ca/p/recipes.html
Sweet potato salad that is different
Recipes attributed to Company Coming salad by Jean Pare
Now this really is different. Go ahead and try it.
Cooking oil 2tbsp., 30 mL
Pineapple juice 2 tbsp., 30mL
Lemon juice 1 tbsp., 15 mL
Salt 2tsp., 2 mL
Onion salt 1/4 tsp., 1 mL
Cooked sweet potatoes, cubed 3 cups, 700 mL
Pineapple tidbits, strained 14 Oz., 398 mL
Chopped celery 3/4 cups, 175 mL
Chopped celery 3/4 cups, 175 mL
Silvered almonds 1/4 cup, 50 mL
Combined cooking oil, pineapple and lemon juice in bowl. Add salt and onion salt. Stir. Add potatoes. Stir and allow to marinate about 1 hour.
Add pineapple, celery and almonds. Toss slightly. Makes 10 servings.
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Now this really is different. Go ahead and try it.
Cooking oil 2tbsp., 30 mL
Pineapple juice 2 tbsp., 30mL
Lemon juice 1 tbsp., 15 mL
Salt 2tsp., 2 mL
Onion salt 1/4 tsp., 1 mL
Cooked sweet potatoes, cubed 3 cups, 700 mL
Pineapple tidbits, strained 14 Oz., 398 mL
Chopped celery 3/4 cups, 175 mL
Chopped celery 3/4 cups, 175 mL
Silvered almonds 1/4 cup, 50 mL
Combined cooking oil, pineapple and lemon juice in bowl. Add salt and onion salt. Stir. Add potatoes. Stir and allow to marinate about 1 hour.
Add pineapple, celery and almonds. Toss slightly. Makes 10 servings.
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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
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Vegan and raw recipe - Mango Chutney
Raw food, volume 2, Healthy, delicious vegetarian cuisine made with living foods by Lisa Montgomery, editor, Hatherleigh
By Wendy Landiak
Prep. 20 minutes
3 cups mango
1 tbsp. vinegar
1 tbsp. lime juice and zest
1 tbsp. freshly grated ginger
1 tbsp. freshly grated tumeric
1 bunch cilantro, chopped
1 Italian Chili, chopped.
1/2 cup red bell pepper
A couple pinches of Himalayan sea salt
Blend ingredients in a Vitamix blender. If you desire more sweetness, use 1/2 cupdates/rasins puree or 1/4 cup maple syrup.
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will Personally Coach You How to Get There The Easy Way
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Celebrity Patti Stanger Will Coach You To Get Him/Her
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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to 1000 free AND HEALTHY recipes and counting
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By Wendy Landiak
Prep. 20 minutes
3 cups mango
1 tbsp. vinegar
1 tbsp. lime juice and zest
1 tbsp. freshly grated ginger
1 tbsp. freshly grated tumeric
1 bunch cilantro, chopped
1 Italian Chili, chopped.
1/2 cup red bell pepper
A couple pinches of Himalayan sea salt
Blend ingredients in a Vitamix blender. If you desire more sweetness, use 1/2 cupdates/rasins puree or 1/4 cup maple syrup.
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will Personally Coach You How to Get There The Easy Way
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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to 1000 free AND HEALTHY recipes and counting
http://kylejnorton.blogspot.ca/p/recipes.html
Wednesday, 9 July 2014
Dehydroascorbic acid (DHA)(*) 12% concentration regained the youthfulness of Forearm between the Wrist and Elbow in stimulated reproduction of Collagen against Sagging skin
By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, The Alan Hopkinson Daily, etc,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com
Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal pharma and Bio science, ISSN 0975-6299. All right reserved
All right reserved
I have truly believed that scientists have found a natural ingredient for define-aging, but it was shelved as it offers no commercial value. If one is published with effectiveness more superior than the currently sold products, it may be a death spell to many companies which rely totally in selling cosmetic products.
Anti-aging and maintaining our youthful appearance has been researched throughout human civilization. Today, these researchers have become more aggressive as finding a workable agent may produce billions of dollars of profits to the found company. According to statistics, Global Anti-Aging Products Market will reach $291.9 Billion by 2015.
Dehydroascorbic acid (DHA)(*) 12% concentration may be a potent solution in regained the youthfulness of forearm between the wrist and elbow in stimulated reproduction of collagen against Skin sagging due to aging progression.
Abstract
Introduction
Skin aging is one of the most visible ageing processes that occur constantly in our skin organ. Many ingredients from synthetic and natural sources have been proven in studies to have certain effects on skin aging. In our previous study, Dehydroascorbic acid (DHA) at 4% showed a significant improvement in smoothing of the skin, skin elasticity, firming, disappearance of black and white heads, liver spots, pigmentation, and healing acne and acne scars. In this study, Dehydroascorbic acid (DHA) at 12% is tested for its effectiveness in stimulated reproduction of collagen in the forearm between the wrist and elbow.
Method of Experimentation
10 Patients at age 59 -60 (5 females and 5 males; 5 Caucasians, 3 Asians and 2 Africans) were recruited to test for aging process due to loss of collagen causes of skin sagging in the forearm (left or right) between the wrist and elbow.
Patients must also agree during the study that they will not to use any other topical products (such as including moisturizers, sunscreens, and fragrances, make-up and any facial procedures such as peels, facials, microdermabrasion, and injection of botulinum toxin type A or dermal fillers) but the testing solution. The study also examines the patient with any cosmetic surgery and/or medication use of which may interfere with the study, as well as history of facial skin diseases. All patients are also required to sign an informed consent. Solutions of Dehydroascorbic acid (DHA)(*)were remixed every 3 days in order to maintain their refreshness and concentration levels.
Patients were instructed to stir the solution well with wooden chopstick or ice cream stick and wear glove when apply the solution to prevent oxidation causes of brownness in the palm and figure nails due to high concentration of the solution, as well as to cover the applied areas before going out to extreme sunlight.
Patients were also instructed to apply the provided solution on their forearm between the wrist and elbow for a duration of 12 weeks. Forearm up to the wrist examinations were conducted and recorded every 4 weeks.
Results
All patients completed the trial. Topical administration of Dehydroascorbic acid (DHA)(*) 12% showed to stimulate the reproduction of collagen in enhancing the youthfulness of the applied area up to 95% in 4 patients
Conclusion
Treatment of concentrations of Dehydroascorbic acid (DHA)(*) at 12 % exhibited a significant efficacy in rejuvenation of the youthfulness of forearm between the wrist and elbow through reproduction of collagen skin smoothing, elasticity, firming, probably through anti-inflammatory and skin absorption pathways, in doses, skin aging progression and durative depending manner. It may be used to rejuvenate the skin in other parts of the body. Since the experimental group is small in nature, further studies with a larger sample size are necessary to improve the ingredient’s validation.
Worldwide copyright protection. Reproduction and redistribution in part(s) or full of the study are prohibited without permission of the writer. By clicking the link, you promise not to discuss the content of the study to anyone but yourself.
Introduction
Skin aging is one of the most visible aging processes that occur constantly in our skin. According to the Clinical Centre of Nis, certain plant extracts may have the ability to scavenge free radicals to protect the skin matrix through the inhibition of enzymatic degradation, or to promote collagen synthesis in the skin, and affect skin elasticity and tightness (a). Another study suggested that free radicals induced domino effects in production of reactive oxygen species and can react with DNA, proteins, and fatty acids causing oxidative damage and impairment of the antioxidant system, leading to injuries, damage of the regulation pathways of skin causing wrinkles, roughness, appearance of fine lines, lack of elasticity, and de-pigmentation or hyperpigmentation marks (b).
Walking through the drug and commercial cosmetic stores, one can see hundreds of anti-aging creams and products displayed. Many of them have also gone through certain studies for its efficacy with advertisement through media and celebrities. In fact, according to statistics, Global Anti-Aging Products Market will be worth $291.9 Billion by 2015.
Searching through the key word of Dehydroascorbic Acid (Oxidized Vitamin C, DHAA) and skin has yielded no related studies or clinical trials. It may be the result of the solution having no commercial value as it can be made by any cosmetic purchaser, or the studies indicate that L-ascorbic acid must be formulated at pH levels less than 3.5 to enter the skin with maximal concentration of 20% for optimal percutaneous absorption. But according to Dr. Douglas Q. Kitt, Dehydroascorbic Acid (DHAA) permeates stratum corneum at a rate up to 12 times faster than AA. This supports the concept that lower concentrations of DHAA in topical preparations can enhance skin vitamin C levels with less potential side effects (c).
Dehydroascorbic Acid (DHA) (vitamin C supplement oxidized form)
Vitamin C, also known as L-ascorbic acid, is a water-soluble vitamin found in fresh fruits, berries and green vegetables. It is best known for its free radical scavenging activity and regenerating oxidized vitamin E for immune system support. In skin aging, the vitamin may improve solar radiation protection and epidermal aging (1) through production of collagen due to its antioxidant activity (2)(3).
Epidemiological studies linking vitamin C in prevention of skin damage and aging have produced some certain results (3a)(3b)(3c), but the large sample size and multi-centred studies are necessary to validate its effectiveness. Vitamin C oxidized form or dehydroascorbic acid (DHA) processed antiviral and virucidal effects (23) showed to prevent H2O2-induced cell death by increasing the GSH levels mediated by the GPx and GR activities and PPP (17), and regulated neuronal energy metabolism, through facilitating the utilization of glucose via the PPP for antioxidant purposes (18) by increasing antioxidant potential in the central nervous system (19). Dehydroascorbic acid (DHA) may be a potential anti-cancer agent to treat aggressive cancers (20)(21). Dr. Toohey at the Cytoregulation Research said "rapidly-dividing tumour cells make unusually large amounts of homocysteine thiolactone and that administered dehydroascorbic acid enters the cells and converts the thiolactone to mercaptopropionaldehyde which kills the cancer cells" (22).
1. Plasma levels of vitamin C L-ascorbic acid is known for its effects on skin-whitening and against the anti-oxidation causes of skin aging. During the aging process, levels of vitamin C was found to slowly deplete according to the Tokyo Metropolitan Institute of Gerontology in the measurement of plasma and urine of C57BL/6 male mice during 3 to 30 months of aging(4). Therefore, restoration of physiological levels of vitamin C inside the cells might improve the lysosomal degradation (protection of cell from the degradative enzymes through protection of the cytosol) in the outflow pathway cells and prevent the pathogenesis of glaucomadegrade proteins(5).
Unfortunately, some researchers suggested that higher levels of circulating vitamin C may not provide protection against incident radiographic knee OA, and be associated with an increased risk of knee OA(6) and the 1Panorama Research Institute and Regenerative Sciences Institute, insisted "careful attention to individual and family medical history and personal genomic data may prove essential to make wise dietary and supplement choices to be combined with exercise”(7).
2. The effects
According to the Minghsin University of Science and Technology, in doses of a dependent manner, the concentration of L-ascorbic acid induced absorption of the collagen solution in exhibition of smoothing wrinkles and clear up spots(8). Ascorbic acid (AA) is essential in stimulating collagen gene expression. In type 1 and type 4 collagen and SVCT2, the vitamin was found to enhance the expression of type 1 and type 4 collagens and SVCT2 mRNA in cultured human skin fibroblasts at 100 μM AA placed every 24h for 5 days to prevent depletion(9). The Chiang Mai University study also supported the effects of ascorbic acid in the anti-aging process through exhibition pro and active MMP-2 inhibitory(10). Other studies suggested the combined vitamins, including vitamin C in a single formulation had a slightly lower degradation rate and more stable formulations as compared to different preparations containing only one of the vitamins(11)(12). Amazingly, in vivo, application of vitamin C showed a significant reduction of oxidative stress in the skin, an improvement of the epidermal-dermal microstructure and a reduction of fine lines and wrinkles in aged skin within a relatively short period of time of product application(13). The Bruce and Associates study also insisted the effectiveness of vitamin C application over a 12 week period as the vitamin enhanced the overall intensity of pigmentation, fine lines and wrinkles, tactile roughness, and laxity with a 100% satisfaction of overall appearance of the tested subjects’ skin(14).
1. Skin roughness and Scaliness
Skin roughness due to aging is a result of dead skin cells shedding more slowly, and building up in the upper layer of skin causing skin complexion to become rough and dull. According to the University of California at San Francisco, they are the result of aging and anatomic site of which demonstrated a significant influence on skin roughness and scaliness(25). Another study suggested that frictional properties of skin are dependent on more than water content or non-apparent sweating and the role of sebum secretion may be one possible factor(26), or it may be result of depletion of surface lipid content(27).
2. Wrinkles
Wrinkles are also associated with aging, hormonal status, smoking, and intercurrent disease according to the study by the University of California-San Francisco(28). Some researchers suggested that vitamin C may play an important role in collagen production due to its antioxidant properties(28). Another study indicated a positive anti-wrinkle effect through consumption of a mixture of soy isoflavones, lycopene, vitamin C, vitamin E, and fish oil(29).
3. Skin elasticity and firming
Skin sagging is a result of a loss of collagen and elastin of the skin due to aging in combination with the dreaded pull of gravity. The study of a novel dietary supplement (Imedeen Prime Renewal) including soy extract, fish protein polysaccharides, extracts from white tea, grape seed and tomato, vitamins C and E as well as zinc and chamomile extract, showed to inhibit forehead, periocular and perioral wrinkles, mottled pigmentation, laxity, sagging, under eye dark circles, and overall appearance. After 6 months treatment, it was suggested that the formula may provide improved condition, structure and firmness of the skin in post-menopausal women(30). Other studies insisted that since vitamin C (Vit. C) in the form of L-ascorbic acid (Asc) can accelerate wound healing(33)(32) and protect fatty tissues from oxidation damage(33), it may play an integral role in collagen synthesis of reducing wrinkles and skin sagging(34)(35)
5. Liver and aging spots
Liver spot is a condition of brown or black spots appearing on the surface of the skin due to aging and exposure to ultraviolet radiation from the sun. According to skin care guides, high concentration of Vitamin C may improve the skin and lighten the spots(36). Other articles insisted that liver spots may be the result of a deficiency of vitamin C(37). According to the Duke University Medical Center, the application of topical solutions containing vitamins C and E provided protection for human skin against damage caused by ultraviolet radiation(38)(39)(40)(41).
6. Pigmentation
Skin pigmentation disorder is a result of damage most likely caused by UV sunlight, or unhealthy cells due to aging affecting the production of melanin. Vitamin C topical and by iontophoresis are found effectively in aiding post-laser hyperpigmentation or short and long term treatment (42) for melism (43). In an experiment where 29 females with melisma enrolled for iontophoresis, a vitamin C solution was applied to one side of the face, while distilled water was applied to the other side as a control, treatment with colorimeter site showed a significant decrease in the luminance value, (a photometric measure of the luminous intensity per unit area of light) compared to that of the control site (44).
8. Acne and Acne scars
According to Dr. GEORGE E. MORRIS, M.D., in a study of 60 patients with acne being given 8 oz of citrus juice twice daily and vitamin C in 3 gm a day, after 4 months 43 showed improvement, 10 failed to show improvement and 7 did not return for follow up(45). Some articles showed that vitamin C may be effective in the reduction of the formation of acne scars through it’s anti-inflammatory and free radical scavenger activities(46), but no study has been found through searching on PubMed.
9. Back and White heads
Black and white heads are the result of a skin pore becoming clogged with sebum from the body's natural oil and becoming black heads if oxidized. No study has been found specifically for the key word vitamin C and back and white heads on PubMed.
10. Fine Lines
No study and been found.
Method
A total of 10p atients were recruited with ages ranging from 59 - 60 (5 Caucasians, 3 Asians and 2 Africans, and 5 females and 5 males) to test for the effectiveness in the difference of concentrations of Dehydroascorbic acid (DHA) at 12% ( 24000mg diluted into 100 mL of hot water which is let cool before refrigerating).
Patients are eligible to enter this study
Selection was based on those who had moderate to severe forearm wrinkles. Patients must also agree during the study that they will not to use any other topical products but the testing solution, such as moisturizers, sunscreens, fragrances, make-up, and any facial procedures such as peels, facials, microdermabrasion, and injection of botulinum toxin type A or dermal fillers. The study also examines the patient with any cosmetic surgery and medication use which may interfere with the study, as well as history of facial skin diseases. All patients are also required to sign an informed consent.
Patients were instructed to stir the solution well with wooden chopstick or ice cream stick and wear glove when apply the solution to prevent oxidation causes of brownness in the palm and figure nails due to high concentration of the solution, as well as to cover the applied areas before going out to extreme sunlight.
Patients were also instructed to apply the provided solution on their forearm up to the wrist for a duration of 12 weeks. Facial skin examinations were conducted and recorded every 4 weeks.
Total patients study Genders Ages
Ethnicity 5 Females, 59 - 60
5 Caucasians, 5 Males,
3 Asians,
2 Africans
Initial examination
Based on scale of 0 - 4 (0 - Not applicable, 1 - Minimum, 2 - Mild, 3 - Moderated, 4 - Severe)
6 patients with wrinkle on the forearm between the wrist and elbow range from mild to moderated
4 patients with wrinkle on the forearm up to the wrist range from moderated to severe.
Treatment solution
1. Equipment's contained a solution provided or mixed by patients as instructed. All solutions were refrigerated to protect its effectiveness.
2. Solution was applied twice per day, once in the morning and once in the evening.
Patients applied the solution first to the affected areas using the sponge path containing Dehydroascorbic acid (DHA)(*) at 12% with little pressure to enhance the absorption for about 1 minute. The sponge path would then be cleared and the solution would be returned to the refrigerator.
Patients were also advised not to let the solution get into their eyes. If this did happen, patients were advised to use cold water to clean them out.
Outcome measure
The results will be measured 3 times:
1. The end of week 4
2. The end of week 8
3. The end of week 12
Patients were measured for the intensity of the applicable areas and to check for efficacy of the solution by comparing to the base line.
Results
Observation report
At the end of weeks 4
Dehydroascorbic acid (DHA)(*) at 12% concentration showed to exhibit the reproduction of collagen as follow
6 Patient with reduction of skin sagging of forearm between the wrist and elbow of 75%
4 Patient with reduction of forearm between the wrist and elbow of 80%
At the end of weeks 4
Dehydroascorbic acid (DHA)(*) at 12% concentration showed to exhibit the reproduction of collagen as follow
6 Patient with reduction of skin sagging of forearm between the wrist and elbow of 85%
4 Patient with reduction of skin sagging of forearm between the wrist and elbow of 90%
At the end of weeks 4
Dehydroascorbic acid (DHA)(*) at 12% concentration showed to exhibit the reproduction of collagen as follow
6 Patient with reduction of skin sagging of forearm between the wrist and elbow of 90%
4 Patient with reduction of skin sagging of forearm between the wrist and elbow of 95%
As the data indicates, patient satisfaction with the solution and the progression of skin sagging reduction.
Tolerability
Through over 12 weeks of application with the designed solution, no adverse effect has been reported in the group.
Discussion
Dehydroascorbic acid (DHA)(*) showed the most efficacy in enhanced smoothness, firmness, and elasticity of the skin through stimulation the production of collagen on forearm between the wrist and elbow, probably through its antioxidant activities via inflammatory pathways, and skin absorption property. It may be used in other parts of the body including facial skin.
The efficacy of the solutions indicated a logical thinking through maintaining healthy skin by preventing the loss of collagen due to aging is the most effective way to slow down the aging progression. Dehydroascorbic acid (DHA)(*) at 12% concentration may provide us with more insight with this astonished result, but further study is necessary to rule out any adverse effect and improve its validation, due to small sample size.
Please make sure that you discuss the use of any topical solution in the study with your doctor or related field specialist before applying. Please Donate for funding the larger sample size study to improve the validation of this discovery.
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References
(*) http://authors.library.caltech.edu/11677/1/BORjbc37a.pdf (The oxidation of ascorbic acid and its reduction in vitro and vivo)
(a) Skin ageing: natural weapons and strategies by Binic I1, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D.(PubMed)
(b) Phytoconstituents as photoprotective novel cosmetic formulations by Saraf S1, Kaur CD.(PubMed)
(c) Topical Dehydroascorbic Acid (Oxidized Vitamin C) Permeates Stratum Corneum More Rapidly Than Ascorbic Acid by Douglas Q Kitt
(1) Active ingredients against human epidermal aging by Lorencini M1, Brohem CA2, Dieamant GC2, Zanchin NI3, Maibach HI(PubMed)
(2) CAM use in dermatology. Is there a potential role for honey, green tea, and vitamin C? by Barbosa NS1, Kalaaji AN2.(PubMed)
(3) The science behind vitamins by Linder J.(PubMed)
(3a) Split-face study of topical 23.8% L-ascorbic acid serum in treating photo-aged skin by Xu TH1, Chen JZ, Li YH, Wu Y, Luo YJ, Gao XH, Chen HD(PubMed)
(3b) Use of topical ascorbic acid and its effects on photodamaged skin topography by Traikovich SS.(PubMed)
(3c) Formulation and in-vivo evaluation of a cosmetic multiple emulsion containing vitamin C and wheat protein by Akhtar N1, Yazan Y(PubMed)
(4) Ascorbic acid levels in various tissues, plasma and urine of mice during aging by Iwama M1, Amano A, Shimokado K, Maruyama N, Ishigami A.(PubMed)
(5) Ascorbic Acid Modulation of Iron Homeostasis and Lysosomal Function in Trabecular Meshwork Cells by Xu P1, Lin Y, Porter K, Liton PB(PubMed)
(6) High plasma levels of vitamin C and E are associated with incident radiographic knee osteoarthritis by Chaganti RK1, Tolstykh I2, Javaid MK3, Neogi T4, Torner J5, Curtis J6, Jacques P7, Felson D4, Lane NE8, Nevitt MC9; Multicenter Osteoarthritis Study Group (MOST)(PubMed)
(7) Trade-offs between anti-aging dietary supplementation and exercise by Mendelsohn AR1, Larrick JW(PubMed)
(8) [The study of absorption efficiency and restoring effects of collagen and ascorbic acid on aged skin by fluorescence and reflection spectroscopy].[Article in Chinese] by Yang BW1, Lin YM, Wang SY, Yeh DC.(PubMed)
(9) Ascorbic acid enhances the expression of type 1 and type 4 collagen and SVCT2 in cultured human skin fibroblasts by Kishimoto Y1, Saito N, Kurita K, Shimokado K, Maruyama N, Ishigami A.(PubMed)
(10) Nanoscale gelatinase A (MMP-2) inhibition on human skin fibroblasts of Longkong (Lansium domesticum Correa) leaf extracts for anti-aging by Manosroi A1, Kumguan K, Chankhampan C, Manosroi W, Manosroi J.(PubMed)
(11) Benefits of combinations of vitamin A, C and E derivatives in the stability of cosmetic formulations by Gianeti MD1, Gaspar LR, Camargo FB Jr, Campos PM.(PubMed)
(12) Stability of vitamin C derivatives in topical formulations containing lipoic acid, vitamins A and E. by Segall AI1, Moyano MA.(PubMed)
(13) Topical activity of ascorbic acid: from in vitro optimization to in vivo efficacy by Raschke T1, Koop U, Düsing HJ, Filbry A, Sauermann K, Jaspers S, Wenck H, Wittern KP.(PubMed)
(14) Evaluation of a prescription strength 4% hydroquinone/10% L-ascorbic acid treatment system for normal to oily skin by Bruce S1, Watson J(PubMed)
(15) Fatal vitamin C-associated acute renal failure by McHugh GJ, Graber ML, Freebairn RC.(PubMed)
(16) Ascorbic acid overdosing: a risk factor for calcium oxalate nephrolithiasis by Urivetzky M, Kessaris D, Smith AD.(PubMed)
(17) Dehydroascorbic acid prevents oxidative cell death through a glutathione pathway in primary astrocytes by Kim EJ1, Park YG, Baik EJ, Jung SJ, Won R, Nahm TS, Lee BH.(PubMed)
(18) The oxidized form of vitamin C, dehydroascorbic acid, regulates neuronal energy metabolism by Cisternas P1, Silva-Alvarez C, Martínez F, Fernandez E, Ferrada L, Oyarce K, Salazar K, Bolaños JP, Nualart F.(PubMed)
(19) Vitamin C crosses the blood-brain barrier in the oxidized form through the glucose transporters by Agus DB1, Gambhir SS, Pardridge WM, Spielholz C, Baselga J, Vera JC, Golde DW.(PubMed)
(20) Expression and/or activity of the SVCT2 ascorbate transporter may be decreased in many aggressive cancers, suggesting potential utility for sodium bicarbonate and dehydroascorbic acid in cancer therapy by McCarty MF.(PubMed)
(21) Gelatin crosslinked with dehydroascorbic acid as a novel scaffold for tissue regeneration with simultaneous antitumor activity by Falconi M1, Salvatore V, Teti G, Focaroli S, Durante S, Nicolini B, Mazzotti A, Orienti I.(PubMed)
(22) Dehydroascorbic acid as an anti-cancer agent by Toohey JI.(PubMed)
(23) Antiviral and virucidal activities of natural products by Arakawa T1, Yamasaki H, Ikeda K, Ejima D, Naito T, Koyama AH.(PubMed)
(24) Topical L-ascorbic acid: percutaneous absorption studies, by Pinnell SR1, Yang H, Omar M, Monteiro-Riviere N, DeBuys HV, Walker LC, Wang Y, Levine M.(PubMed)
(25) Use of topical ascorbic acid and its effects on photodamaged skin topography by Traikovich SS.(PubMed)
(26) Frictional properties of human skin: relation to age, sex and anatomical region, stratum corneum hydration and transepidermal water loss by Cua AB1, Wilhelm KP, Maibach HI.(PubMed)
(27) Skin surface lipid and skin friction: relation to age, sex and anatomical region by Cua AB1, Wilhelm KP, Maibach HI.(PubMed)
(28) Skin aging. Effect on transepidermal water loss, stratum corneum hydration, skin surface pH, and casual sebum content by Wilhelm KP1, Cua AB, Maibach HI.(PubMed)
(29) Wrinkle reduction in post-menopausal women consuming a novel oral supplement: a double-blind placebo-controlled randomized study by Jenkins G1, Wainwright LJ, Holland R, Barrett KE, Casey J.(PubMed)
(30) Effect of a novel dietary supplement on skin aging in post-menopausal women by Skovgaard GR1, Jensen AS, Sigler ML.(PubMed)
(31) Vitamin C: a wound healing perspective, by Moores J.(PubMed)
(32) Nutrition 411: revisiting vitamin C and wound healing by Collins N.(PubMed)
(33) Ef[The study of absorption efficiency and restoring effects of collagen and ascorbic acid on aged skin by fluorescence and reflection spectroscopy].[Article in Chinese] by Yang BW1, Lin YM, Wang SY, Yeh DC.(PubMed)
(34) Regulation of collagen synthesis in human dermal fibroblasts in contracted collagen gels by ascorbic acid, growth factors, and inhibitors of lipid peroxidation by Gessin JC1, Brown LJ, Gordon JS, Berg RA(PubMed)
(35) Electroporation-mediated topical delivery of vitamin C for cosmetic applications by Zhang L1, Lerner S, Rustrum WV, Hofmann GA.(PubMed)
(36) Liver Spot Removal: Vitamin C Products(Skin care guide)
(37) Lack of vitamin leads to brown spot on hand(livestrong)
(38) A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation by Murray JC1, Burch JA, Streilein RD, Iannacchione MA, Hall RP, Pinnell SR.(PubMed)
(39) UV photoprotection by combination topical antioxidants vitamin C and vitamin E by Lin JY1, Selim MA, Shea CR, Grichnik JM, Omar MM, Monteiro-Riviere NA, Pinnell SR.(PubMed)
(40) Protective effects of topical antioxidants in humans by Dreher F1, Maibach H.(PubMed)
(41) Effectiveness of antioxidants (vitamin C and E) with and without sunscreens as topical photoprotectants by Darr D1, Dunston S, Faust H, Pinnell S.(PubMed)
(42) Successful short-term and long-term treatment of melasma and postinflammatory hyperpigmentation using vitamin C with a full-face iontophoresis mask and a mandelic/malic acid skin care regimen by Taylor MB1, Yanaki JS, Draper DO, Shurtz JC, Coglianese M.(PubMed)
(43) Intravenous vitamin C in the treatment of post-laser hyperpigmentation for melasma: a short report by Lee GS.(PubMed)
(44) A randomized, double-blind, placebo-controlled trial of vitamin C iontophoresis in melisma by Huh CH1, Seo KI, Park JY, Lim JG, Eun HC, Park KC.(PubMed)
(45) USE OF VITAMIN C IN ACNE VULGARIS by GEORGE E. MORRIS, M.D.(Jama dermatology)
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I have truly believed that scientists have found a natural ingredient for define-aging, but it was shelved as it offers no commercial value. If one is published with effectiveness more superior than the currently sold products, it may be a death spell to many companies which rely totally in selling cosmetic products.
Anti-aging and maintaining our youthful appearance has been researched throughout human civilization. Today, these researchers have become more aggressive as finding a workable agent may produce billions of dollars of profits to the found company. According to statistics, Global Anti-Aging Products Market will reach $291.9 Billion by 2015.
Dehydroascorbic acid (DHA)(*) 12% concentration may be a potent solution in regained the youthfulness of forearm between the wrist and elbow in stimulated reproduction of collagen against Skin sagging due to aging progression.
Abstract
Introduction
Skin aging is one of the most visible ageing processes that occur constantly in our skin organ. Many ingredients from synthetic and natural sources have been proven in studies to have certain effects on skin aging. In our previous study, Dehydroascorbic acid (DHA) at 4% showed a significant improvement in smoothing of the skin, skin elasticity, firming, disappearance of black and white heads, liver spots, pigmentation, and healing acne and acne scars. In this study, Dehydroascorbic acid (DHA) at 12% is tested for its effectiveness in stimulated reproduction of collagen in the forearm between the wrist and elbow.
Method of Experimentation
10 Patients at age 59 -60 (5 females and 5 males; 5 Caucasians, 3 Asians and 2 Africans) were recruited to test for aging process due to loss of collagen causes of skin sagging in the forearm (left or right) between the wrist and elbow.
Patients must also agree during the study that they will not to use any other topical products (such as including moisturizers, sunscreens, and fragrances, make-up and any facial procedures such as peels, facials, microdermabrasion, and injection of botulinum toxin type A or dermal fillers) but the testing solution. The study also examines the patient with any cosmetic surgery and/or medication use of which may interfere with the study, as well as history of facial skin diseases. All patients are also required to sign an informed consent. Solutions of Dehydroascorbic acid (DHA)(*)were remixed every 3 days in order to maintain their refreshness and concentration levels.
Patients were instructed to stir the solution well with wooden chopstick or ice cream stick and wear glove when apply the solution to prevent oxidation causes of brownness in the palm and figure nails due to high concentration of the solution, as well as to cover the applied areas before going out to extreme sunlight.
Patients were also instructed to apply the provided solution on their forearm between the wrist and elbow for a duration of 12 weeks. Forearm up to the wrist examinations were conducted and recorded every 4 weeks.
Results
All patients completed the trial. Topical administration of Dehydroascorbic acid (DHA)(*) 12% showed to stimulate the reproduction of collagen in enhancing the youthfulness of the applied area up to 95% in 4 patients
Conclusion
Treatment of concentrations of Dehydroascorbic acid (DHA)(*) at 12 % exhibited a significant efficacy in rejuvenation of the youthfulness of forearm between the wrist and elbow through reproduction of collagen skin smoothing, elasticity, firming, probably through anti-inflammatory and skin absorption pathways, in doses, skin aging progression and durative depending manner. It may be used to rejuvenate the skin in other parts of the body. Since the experimental group is small in nature, further studies with a larger sample size are necessary to improve the ingredient’s validation.
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Introduction
Skin aging is one of the most visible aging processes that occur constantly in our skin. According to the Clinical Centre of Nis, certain plant extracts may have the ability to scavenge free radicals to protect the skin matrix through the inhibition of enzymatic degradation, or to promote collagen synthesis in the skin, and affect skin elasticity and tightness (a). Another study suggested that free radicals induced domino effects in production of reactive oxygen species and can react with DNA, proteins, and fatty acids causing oxidative damage and impairment of the antioxidant system, leading to injuries, damage of the regulation pathways of skin causing wrinkles, roughness, appearance of fine lines, lack of elasticity, and de-pigmentation or hyperpigmentation marks (b).
Walking through the drug and commercial cosmetic stores, one can see hundreds of anti-aging creams and products displayed. Many of them have also gone through certain studies for its efficacy with advertisement through media and celebrities. In fact, according to statistics, Global Anti-Aging Products Market will be worth $291.9 Billion by 2015.
Searching through the key word of Dehydroascorbic Acid (Oxidized Vitamin C, DHAA) and skin has yielded no related studies or clinical trials. It may be the result of the solution having no commercial value as it can be made by any cosmetic purchaser, or the studies indicate that L-ascorbic acid must be formulated at pH levels less than 3.5 to enter the skin with maximal concentration of 20% for optimal percutaneous absorption. But according to Dr. Douglas Q. Kitt, Dehydroascorbic Acid (DHAA) permeates stratum corneum at a rate up to 12 times faster than AA. This supports the concept that lower concentrations of DHAA in topical preparations can enhance skin vitamin C levels with less potential side effects (c).
Dehydroascorbic Acid (DHA) (vitamin C supplement oxidized form)
Vitamin C, also known as L-ascorbic acid, is a water-soluble vitamin found in fresh fruits, berries and green vegetables. It is best known for its free radical scavenging activity and regenerating oxidized vitamin E for immune system support. In skin aging, the vitamin may improve solar radiation protection and epidermal aging (1) through production of collagen due to its antioxidant activity (2)(3).
Epidemiological studies linking vitamin C in prevention of skin damage and aging have produced some certain results (3a)(3b)(3c), but the large sample size and multi-centred studies are necessary to validate its effectiveness. Vitamin C oxidized form or dehydroascorbic acid (DHA) processed antiviral and virucidal effects (23) showed to prevent H2O2-induced cell death by increasing the GSH levels mediated by the GPx and GR activities and PPP (17), and regulated neuronal energy metabolism, through facilitating the utilization of glucose via the PPP for antioxidant purposes (18) by increasing antioxidant potential in the central nervous system (19). Dehydroascorbic acid (DHA) may be a potential anti-cancer agent to treat aggressive cancers (20)(21). Dr. Toohey at the Cytoregulation Research said "rapidly-dividing tumour cells make unusually large amounts of homocysteine thiolactone and that administered dehydroascorbic acid enters the cells and converts the thiolactone to mercaptopropionaldehyde which kills the cancer cells" (22).
1. Plasma levels of vitamin C L-ascorbic acid is known for its effects on skin-whitening and against the anti-oxidation causes of skin aging. During the aging process, levels of vitamin C was found to slowly deplete according to the Tokyo Metropolitan Institute of Gerontology in the measurement of plasma and urine of C57BL/6 male mice during 3 to 30 months of aging(4). Therefore, restoration of physiological levels of vitamin C inside the cells might improve the lysosomal degradation (protection of cell from the degradative enzymes through protection of the cytosol) in the outflow pathway cells and prevent the pathogenesis of glaucomadegrade proteins(5).
Unfortunately, some researchers suggested that higher levels of circulating vitamin C may not provide protection against incident radiographic knee OA, and be associated with an increased risk of knee OA(6) and the 1Panorama Research Institute and Regenerative Sciences Institute, insisted "careful attention to individual and family medical history and personal genomic data may prove essential to make wise dietary and supplement choices to be combined with exercise”(7).
2. The effects
According to the Minghsin University of Science and Technology, in doses of a dependent manner, the concentration of L-ascorbic acid induced absorption of the collagen solution in exhibition of smoothing wrinkles and clear up spots(8). Ascorbic acid (AA) is essential in stimulating collagen gene expression. In type 1 and type 4 collagen and SVCT2, the vitamin was found to enhance the expression of type 1 and type 4 collagens and SVCT2 mRNA in cultured human skin fibroblasts at 100 μM AA placed every 24h for 5 days to prevent depletion(9). The Chiang Mai University study also supported the effects of ascorbic acid in the anti-aging process through exhibition pro and active MMP-2 inhibitory(10). Other studies suggested the combined vitamins, including vitamin C in a single formulation had a slightly lower degradation rate and more stable formulations as compared to different preparations containing only one of the vitamins(11)(12). Amazingly, in vivo, application of vitamin C showed a significant reduction of oxidative stress in the skin, an improvement of the epidermal-dermal microstructure and a reduction of fine lines and wrinkles in aged skin within a relatively short period of time of product application(13). The Bruce and Associates study also insisted the effectiveness of vitamin C application over a 12 week period as the vitamin enhanced the overall intensity of pigmentation, fine lines and wrinkles, tactile roughness, and laxity with a 100% satisfaction of overall appearance of the tested subjects’ skin(14).
1. Skin roughness and Scaliness
Skin roughness due to aging is a result of dead skin cells shedding more slowly, and building up in the upper layer of skin causing skin complexion to become rough and dull. According to the University of California at San Francisco, they are the result of aging and anatomic site of which demonstrated a significant influence on skin roughness and scaliness(25). Another study suggested that frictional properties of skin are dependent on more than water content or non-apparent sweating and the role of sebum secretion may be one possible factor(26), or it may be result of depletion of surface lipid content(27).
2. Wrinkles
Wrinkles are also associated with aging, hormonal status, smoking, and intercurrent disease according to the study by the University of California-San Francisco(28). Some researchers suggested that vitamin C may play an important role in collagen production due to its antioxidant properties(28). Another study indicated a positive anti-wrinkle effect through consumption of a mixture of soy isoflavones, lycopene, vitamin C, vitamin E, and fish oil(29).
3. Skin elasticity and firming
Skin sagging is a result of a loss of collagen and elastin of the skin due to aging in combination with the dreaded pull of gravity. The study of a novel dietary supplement (Imedeen Prime Renewal) including soy extract, fish protein polysaccharides, extracts from white tea, grape seed and tomato, vitamins C and E as well as zinc and chamomile extract, showed to inhibit forehead, periocular and perioral wrinkles, mottled pigmentation, laxity, sagging, under eye dark circles, and overall appearance. After 6 months treatment, it was suggested that the formula may provide improved condition, structure and firmness of the skin in post-menopausal women(30). Other studies insisted that since vitamin C (Vit. C) in the form of L-ascorbic acid (Asc) can accelerate wound healing(33)(32) and protect fatty tissues from oxidation damage(33), it may play an integral role in collagen synthesis of reducing wrinkles and skin sagging(34)(35)
5. Liver and aging spots
Liver spot is a condition of brown or black spots appearing on the surface of the skin due to aging and exposure to ultraviolet radiation from the sun. According to skin care guides, high concentration of Vitamin C may improve the skin and lighten the spots(36). Other articles insisted that liver spots may be the result of a deficiency of vitamin C(37). According to the Duke University Medical Center, the application of topical solutions containing vitamins C and E provided protection for human skin against damage caused by ultraviolet radiation(38)(39)(40)(41).
6. Pigmentation
Skin pigmentation disorder is a result of damage most likely caused by UV sunlight, or unhealthy cells due to aging affecting the production of melanin. Vitamin C topical and by iontophoresis are found effectively in aiding post-laser hyperpigmentation or short and long term treatment (42) for melism (43). In an experiment where 29 females with melisma enrolled for iontophoresis, a vitamin C solution was applied to one side of the face, while distilled water was applied to the other side as a control, treatment with colorimeter site showed a significant decrease in the luminance value, (a photometric measure of the luminous intensity per unit area of light) compared to that of the control site (44).
8. Acne and Acne scars
According to Dr. GEORGE E. MORRIS, M.D., in a study of 60 patients with acne being given 8 oz of citrus juice twice daily and vitamin C in 3 gm a day, after 4 months 43 showed improvement, 10 failed to show improvement and 7 did not return for follow up(45). Some articles showed that vitamin C may be effective in the reduction of the formation of acne scars through it’s anti-inflammatory and free radical scavenger activities(46), but no study has been found through searching on PubMed.
9. Back and White heads
Black and white heads are the result of a skin pore becoming clogged with sebum from the body's natural oil and becoming black heads if oxidized. No study has been found specifically for the key word vitamin C and back and white heads on PubMed.
10. Fine Lines
No study and been found.
Method
A total of 10p atients were recruited with ages ranging from 59 - 60 (5 Caucasians, 3 Asians and 2 Africans, and 5 females and 5 males) to test for the effectiveness in the difference of concentrations of Dehydroascorbic acid (DHA) at 12% ( 24000mg diluted into 100 mL of hot water which is let cool before refrigerating).
Patients are eligible to enter this study
Selection was based on those who had moderate to severe forearm wrinkles. Patients must also agree during the study that they will not to use any other topical products but the testing solution, such as moisturizers, sunscreens, fragrances, make-up, and any facial procedures such as peels, facials, microdermabrasion, and injection of botulinum toxin type A or dermal fillers. The study also examines the patient with any cosmetic surgery and medication use which may interfere with the study, as well as history of facial skin diseases. All patients are also required to sign an informed consent.
Patients were instructed to stir the solution well with wooden chopstick or ice cream stick and wear glove when apply the solution to prevent oxidation causes of brownness in the palm and figure nails due to high concentration of the solution, as well as to cover the applied areas before going out to extreme sunlight.
Patients were also instructed to apply the provided solution on their forearm up to the wrist for a duration of 12 weeks. Facial skin examinations were conducted and recorded every 4 weeks.
Total patients study Genders Ages
Ethnicity 5 Females, 59 - 60
5 Caucasians, 5 Males,
3 Asians,
2 Africans
Initial examination
Based on scale of 0 - 4 (0 - Not applicable, 1 - Minimum, 2 - Mild, 3 - Moderated, 4 - Severe)
6 patients with wrinkle on the forearm between the wrist and elbow range from mild to moderated
4 patients with wrinkle on the forearm up to the wrist range from moderated to severe.
Treatment solution
1. Equipment's contained a solution provided or mixed by patients as instructed. All solutions were refrigerated to protect its effectiveness.
2. Solution was applied twice per day, once in the morning and once in the evening.
Patients applied the solution first to the affected areas using the sponge path containing Dehydroascorbic acid (DHA)(*) at 12% with little pressure to enhance the absorption for about 1 minute. The sponge path would then be cleared and the solution would be returned to the refrigerator.
Patients were also advised not to let the solution get into their eyes. If this did happen, patients were advised to use cold water to clean them out.
Outcome measure
The results will be measured 3 times:
1. The end of week 4
2. The end of week 8
3. The end of week 12
Patients were measured for the intensity of the applicable areas and to check for efficacy of the solution by comparing to the base line.
Results
Observation report
At the end of weeks 4
Dehydroascorbic acid (DHA)(*) at 12% concentration showed to exhibit the reproduction of collagen as follow
6 Patient with reduction of skin sagging of forearm between the wrist and elbow of 75%
4 Patient with reduction of forearm between the wrist and elbow of 80%
At the end of weeks 4
Dehydroascorbic acid (DHA)(*) at 12% concentration showed to exhibit the reproduction of collagen as follow
6 Patient with reduction of skin sagging of forearm between the wrist and elbow of 85%
4 Patient with reduction of skin sagging of forearm between the wrist and elbow of 90%
At the end of weeks 4
Dehydroascorbic acid (DHA)(*) at 12% concentration showed to exhibit the reproduction of collagen as follow
6 Patient with reduction of skin sagging of forearm between the wrist and elbow of 90%
4 Patient with reduction of skin sagging of forearm between the wrist and elbow of 95%
As the data indicates, patient satisfaction with the solution and the progression of skin sagging reduction.
Tolerability
Through over 12 weeks of application with the designed solution, no adverse effect has been reported in the group.
Discussion
Dehydroascorbic acid (DHA)(*) showed the most efficacy in enhanced smoothness, firmness, and elasticity of the skin through stimulation the production of collagen on forearm between the wrist and elbow, probably through its antioxidant activities via inflammatory pathways, and skin absorption property. It may be used in other parts of the body including facial skin.
The efficacy of the solutions indicated a logical thinking through maintaining healthy skin by preventing the loss of collagen due to aging is the most effective way to slow down the aging progression. Dehydroascorbic acid (DHA)(*) at 12% concentration may provide us with more insight with this astonished result, but further study is necessary to rule out any adverse effect and improve its validation, due to small sample size.
Please make sure that you discuss the use of any topical solution in the study with your doctor or related field specialist before applying. Please Donate for funding the larger sample size study to improve the validation of this discovery.
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References
(*) http://authors.library.caltech.edu/11677/1/BORjbc37a.pdf (The oxidation of ascorbic acid and its reduction in vitro and vivo)
(a) Skin ageing: natural weapons and strategies by Binic I1, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D.(PubMed)
(b) Phytoconstituents as photoprotective novel cosmetic formulations by Saraf S1, Kaur CD.(PubMed)
(c) Topical Dehydroascorbic Acid (Oxidized Vitamin C) Permeates Stratum Corneum More Rapidly Than Ascorbic Acid by Douglas Q Kitt
(1) Active ingredients against human epidermal aging by Lorencini M1, Brohem CA2, Dieamant GC2, Zanchin NI3, Maibach HI(PubMed)
(2) CAM use in dermatology. Is there a potential role for honey, green tea, and vitamin C? by Barbosa NS1, Kalaaji AN2.(PubMed)
(3) The science behind vitamins by Linder J.(PubMed)
(3a) Split-face study of topical 23.8% L-ascorbic acid serum in treating photo-aged skin by Xu TH1, Chen JZ, Li YH, Wu Y, Luo YJ, Gao XH, Chen HD(PubMed)
(3b) Use of topical ascorbic acid and its effects on photodamaged skin topography by Traikovich SS.(PubMed)
(3c) Formulation and in-vivo evaluation of a cosmetic multiple emulsion containing vitamin C and wheat protein by Akhtar N1, Yazan Y(PubMed)
(4) Ascorbic acid levels in various tissues, plasma and urine of mice during aging by Iwama M1, Amano A, Shimokado K, Maruyama N, Ishigami A.(PubMed)
(5) Ascorbic Acid Modulation of Iron Homeostasis and Lysosomal Function in Trabecular Meshwork Cells by Xu P1, Lin Y, Porter K, Liton PB(PubMed)
(6) High plasma levels of vitamin C and E are associated with incident radiographic knee osteoarthritis by Chaganti RK1, Tolstykh I2, Javaid MK3, Neogi T4, Torner J5, Curtis J6, Jacques P7, Felson D4, Lane NE8, Nevitt MC9; Multicenter Osteoarthritis Study Group (MOST)(PubMed)
(7) Trade-offs between anti-aging dietary supplementation and exercise by Mendelsohn AR1, Larrick JW(PubMed)
(8) [The study of absorption efficiency and restoring effects of collagen and ascorbic acid on aged skin by fluorescence and reflection spectroscopy].[Article in Chinese] by Yang BW1, Lin YM, Wang SY, Yeh DC.(PubMed)
(9) Ascorbic acid enhances the expression of type 1 and type 4 collagen and SVCT2 in cultured human skin fibroblasts by Kishimoto Y1, Saito N, Kurita K, Shimokado K, Maruyama N, Ishigami A.(PubMed)
(10) Nanoscale gelatinase A (MMP-2) inhibition on human skin fibroblasts of Longkong (Lansium domesticum Correa) leaf extracts for anti-aging by Manosroi A1, Kumguan K, Chankhampan C, Manosroi W, Manosroi J.(PubMed)
(11) Benefits of combinations of vitamin A, C and E derivatives in the stability of cosmetic formulations by Gianeti MD1, Gaspar LR, Camargo FB Jr, Campos PM.(PubMed)
(12) Stability of vitamin C derivatives in topical formulations containing lipoic acid, vitamins A and E. by Segall AI1, Moyano MA.(PubMed)
(13) Topical activity of ascorbic acid: from in vitro optimization to in vivo efficacy by Raschke T1, Koop U, Düsing HJ, Filbry A, Sauermann K, Jaspers S, Wenck H, Wittern KP.(PubMed)
(14) Evaluation of a prescription strength 4% hydroquinone/10% L-ascorbic acid treatment system for normal to oily skin by Bruce S1, Watson J(PubMed)
(15) Fatal vitamin C-associated acute renal failure by McHugh GJ, Graber ML, Freebairn RC.(PubMed)
(16) Ascorbic acid overdosing: a risk factor for calcium oxalate nephrolithiasis by Urivetzky M, Kessaris D, Smith AD.(PubMed)
(17) Dehydroascorbic acid prevents oxidative cell death through a glutathione pathway in primary astrocytes by Kim EJ1, Park YG, Baik EJ, Jung SJ, Won R, Nahm TS, Lee BH.(PubMed)
(18) The oxidized form of vitamin C, dehydroascorbic acid, regulates neuronal energy metabolism by Cisternas P1, Silva-Alvarez C, Martínez F, Fernandez E, Ferrada L, Oyarce K, Salazar K, Bolaños JP, Nualart F.(PubMed)
(19) Vitamin C crosses the blood-brain barrier in the oxidized form through the glucose transporters by Agus DB1, Gambhir SS, Pardridge WM, Spielholz C, Baselga J, Vera JC, Golde DW.(PubMed)
(20) Expression and/or activity of the SVCT2 ascorbate transporter may be decreased in many aggressive cancers, suggesting potential utility for sodium bicarbonate and dehydroascorbic acid in cancer therapy by McCarty MF.(PubMed)
(21) Gelatin crosslinked with dehydroascorbic acid as a novel scaffold for tissue regeneration with simultaneous antitumor activity by Falconi M1, Salvatore V, Teti G, Focaroli S, Durante S, Nicolini B, Mazzotti A, Orienti I.(PubMed)
(22) Dehydroascorbic acid as an anti-cancer agent by Toohey JI.(PubMed)
(23) Antiviral and virucidal activities of natural products by Arakawa T1, Yamasaki H, Ikeda K, Ejima D, Naito T, Koyama AH.(PubMed)
(24) Topical L-ascorbic acid: percutaneous absorption studies, by Pinnell SR1, Yang H, Omar M, Monteiro-Riviere N, DeBuys HV, Walker LC, Wang Y, Levine M.(PubMed)
(25) Use of topical ascorbic acid and its effects on photodamaged skin topography by Traikovich SS.(PubMed)
(26) Frictional properties of human skin: relation to age, sex and anatomical region, stratum corneum hydration and transepidermal water loss by Cua AB1, Wilhelm KP, Maibach HI.(PubMed)
(27) Skin surface lipid and skin friction: relation to age, sex and anatomical region by Cua AB1, Wilhelm KP, Maibach HI.(PubMed)
(28) Skin aging. Effect on transepidermal water loss, stratum corneum hydration, skin surface pH, and casual sebum content by Wilhelm KP1, Cua AB, Maibach HI.(PubMed)
(29) Wrinkle reduction in post-menopausal women consuming a novel oral supplement: a double-blind placebo-controlled randomized study by Jenkins G1, Wainwright LJ, Holland R, Barrett KE, Casey J.(PubMed)
(30) Effect of a novel dietary supplement on skin aging in post-menopausal women by Skovgaard GR1, Jensen AS, Sigler ML.(PubMed)
(31) Vitamin C: a wound healing perspective, by Moores J.(PubMed)
(32) Nutrition 411: revisiting vitamin C and wound healing by Collins N.(PubMed)
(33) Ef[The study of absorption efficiency and restoring effects of collagen and ascorbic acid on aged skin by fluorescence and reflection spectroscopy].[Article in Chinese] by Yang BW1, Lin YM, Wang SY, Yeh DC.(PubMed)
(34) Regulation of collagen synthesis in human dermal fibroblasts in contracted collagen gels by ascorbic acid, growth factors, and inhibitors of lipid peroxidation by Gessin JC1, Brown LJ, Gordon JS, Berg RA(PubMed)
(35) Electroporation-mediated topical delivery of vitamin C for cosmetic applications by Zhang L1, Lerner S, Rustrum WV, Hofmann GA.(PubMed)
(36) Liver Spot Removal: Vitamin C Products(Skin care guide)
(37) Lack of vitamin leads to brown spot on hand(livestrong)
(38) A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation by Murray JC1, Burch JA, Streilein RD, Iannacchione MA, Hall RP, Pinnell SR.(PubMed)
(39) UV photoprotection by combination topical antioxidants vitamin C and vitamin E by Lin JY1, Selim MA, Shea CR, Grichnik JM, Omar MM, Monteiro-Riviere NA, Pinnell SR.(PubMed)
(40) Protective effects of topical antioxidants in humans by Dreher F1, Maibach H.(PubMed)
(41) Effectiveness of antioxidants (vitamin C and E) with and without sunscreens as topical photoprotectants by Darr D1, Dunston S, Faust H, Pinnell S.(PubMed)
(42) Successful short-term and long-term treatment of melasma and postinflammatory hyperpigmentation using vitamin C with a full-face iontophoresis mask and a mandelic/malic acid skin care regimen by Taylor MB1, Yanaki JS, Draper DO, Shurtz JC, Coglianese M.(PubMed)
(43) Intravenous vitamin C in the treatment of post-laser hyperpigmentation for melasma: a short report by Lee GS.(PubMed)
(44) A randomized, double-blind, placebo-controlled trial of vitamin C iontophoresis in melisma by Huh CH1, Seo KI, Park JY, Lim JG, Eun HC, Park KC.(PubMed)
(45) USE OF VITAMIN C IN ACNE VULGARIS by GEORGE E. MORRIS, M.D.(Jama dermatology)
Food Therapy - Banana as antioxidants
By Kyle J. Norton
Banana is the common name of a genus of tropical herbaceous plants. It can grow from 3 to 9 m and belongs to the family of the lily and the orchid.
Nutrients
1. Vitamin B6
2. Vitamin C
3. Fiber
4. Potassium
5. Magnesium
6. Iron7. Etc.
Chemical constituents
1. Sterols
2. 3-Methyl butyl butanoate ester
3. steryl esters
4. Diacylglycerols,
5. SAteryl glucosides,
6. Long chain fatty alcohols
7. Aromatic compounds
8. Linoleic acid
9. Linolenic acid
10. Oleic acids
11. Lectin
12. Fructooligosaccharides.
Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction. They may have positive, negative or zero charge. The unpaired electrons cause radicals to be highly chemically reactive in the human body, leading to aging and cancers.
BHT and water extracts of banana showed to exhibit its natural antioxidants in preservation of raw poultry meat and meat products, according to Central Institute of Post Harvest Engineering and Technology(1). In the comparison of 4 different Musa sp. leave extracts of hexane, ethyl acetate and methanol antioxidant effect, researchers at the King Saud University, suggested that Antioxidant activity of Musa acuminate exhibited maximum activity among other three Musa species(2).
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Celebrity Patti Stanger Will Coach You To Get Him/Her
and Keep Him/Her for Good,The Simple Way
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to 1000 free AND HEALTHY recipes and counting
http://kylejnorton.blogspot.ca/p/recipes.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca References
(1) Comparative antioxidant effect of BHT and water extracts of banana and sapodilla peels in raw poultry meat by Devatkal SK, Kumboj R, Paul D.(PubMed)
(2) Antibacterial and antioxidant activities of Musa sp. leaf extracts against multidrug resistant clinical pathogens causing nosocomial infection by Karuppiah P1, Mustaffa M.(PubMed)
Banana is the common name of a genus of tropical herbaceous plants. It can grow from 3 to 9 m and belongs to the family of the lily and the orchid.
Nutrients
1. Vitamin B6
2. Vitamin C
3. Fiber
4. Potassium
5. Magnesium
6. Iron7. Etc.
Chemical constituents
1. Sterols
2. 3-Methyl butyl butanoate ester
3. steryl esters
4. Diacylglycerols,
5. SAteryl glucosides,
6. Long chain fatty alcohols
7. Aromatic compounds
8. Linoleic acid
9. Linolenic acid
10. Oleic acids
11. Lectin
12. Fructooligosaccharides.
Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction. They may have positive, negative or zero charge. The unpaired electrons cause radicals to be highly chemically reactive in the human body, leading to aging and cancers.
BHT and water extracts of banana showed to exhibit its natural antioxidants in preservation of raw poultry meat and meat products, according to Central Institute of Post Harvest Engineering and Technology(1). In the comparison of 4 different Musa sp. leave extracts of hexane, ethyl acetate and methanol antioxidant effect, researchers at the King Saud University, suggested that Antioxidant activity of Musa acuminate exhibited maximum activity among other three Musa species(2).
Weight Loss the Easy Ways
Andrea Albright Featured on Health and Fitness Jan. 2015
will Personally Coach You How to Get There The Easy Way
If You Are Looking For a SoulMate
Celebrity Patti Stanger Will Coach You To Get Him/Her
and Keep Him/Her for Good,The Simple Way
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to 1000 free AND HEALTHY recipes and counting
http://kylejnorton.blogspot.ca/p/recipes.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca References
(1) Comparative antioxidant effect of BHT and water extracts of banana and sapodilla peels in raw poultry meat by Devatkal SK, Kumboj R, Paul D.(PubMed)
(2) Antibacterial and antioxidant activities of Musa sp. leaf extracts against multidrug resistant clinical pathogens causing nosocomial infection by Karuppiah P1, Mustaffa M.(PubMed)
Raw and Vegan food recipe - Chutney
Raw food, volume 2, Healthy, delicious vegetarian cuisine made with living foods by Lisa Montgomery, editor, Hatherleigh
by Wendy Landiak
Prep. 15 minutes
1 cup raisins
2 tbsp. raw vinegar (Bragg's)
2 tbsp. fresh cilantro
1 tbsp. fresh ginger
1/2 cup coconut
2 tsp. garam masala spices
Blend ingredients in a Vitamix blender. Add salt as desire. You can also add hot pepper if you wish. If mixture is to thick add water to thin.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to 1000 free AND HEALTHY recipes and counting
http://kylejnorton.blogspot.ca/p/recipes.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Weight Loss the Easy Ways
Andrea Albright Featured on Health and Fitness Jan. 2015
will Personally Coach You How to Get There The Easy Way
If You Are Looking For a SoulMate
Celebrity Patti Stanger Will Coach You To Get Him/Her
and Keep Him/Her for Good,The Simple Way
by Wendy Landiak
Prep. 15 minutes
1 cup raisins
2 tbsp. raw vinegar (Bragg's)
2 tbsp. fresh cilantro
1 tbsp. fresh ginger
1/2 cup coconut
2 tsp. garam masala spices
Blend ingredients in a Vitamix blender. Add salt as desire. You can also add hot pepper if you wish. If mixture is to thick add water to thin.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to 1000 free AND HEALTHY recipes and counting
http://kylejnorton.blogspot.ca/p/recipes.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Weight Loss the Easy Ways
Andrea Albright Featured on Health and Fitness Jan. 2015
will Personally Coach You How to Get There The Easy Way
If You Are Looking For a SoulMate
Celebrity Patti Stanger Will Coach You To Get Him/Her
and Keep Him/Her for Good,The Simple Way
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