Phytochemical Tocopherols Reduce the Risk of Alzheimer's disease and Age-Related Cognitive Decline in Vitamin E Deficient Adults

By Kyle J. Norton

Cognition is the process of the brain including the attention of working memory, producing and comprehending language, learning, reasoning, problem-solving, and decision making.

Cognitive impairment is a condition, that affects a person's thinking, communication, understanding, or memory. Cognitive impairment can be acute or chronic.

Acute cognitive impairment is a short-term health problem caused by delirium, an acutely disturbed state of mind due to drugs (toxicity and withdrawal), electrolyte disturbance, lack of drugs, liver disease, infection, reduced sensory input, intracranial urinary retention/fecal impaction or m Myocardial/metabolic/pulmonary.

Chronic cognitive impairment is a permanent medical condition associated with problems with language, ideomotor and constructive praxis, visual gnosis, spatial attention, learning abilities, and executive functions.

People with mild cognitive impairment (MCI) are at greater risk for the development of dementia, including Alzheimer's Disease.

According to the statistic provided by the Center for Disease Control and Prevention, more than 16 million people in the United States are living with cognitive impairment and these numbers are increasing at an alarming rate.

Sadly, the CDC continued, "An estimated 5.1 million Americans aged 65 years or older may currently have Alzheimer’s disease, the most well-known form of cognitive impairment; this number may rise to 13.2 million by 2050".

The causes of cognitive impairment are unknown. However, researchers suggested that aging, genetically mutated gene inherited from parents, such as Down's Syndrome, Fetal Alcohol Syndrome (FAS), autism, persistent mental health problems, together with unhealthy diet and lifestyle are associated with the onset of cognitive impairment.

Furthermore, hormonal imbalances, physical damage to the portion of the brain that is responsible for controlling cognitive function, and substance abuse are also some major causes of the development of the condition.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, seed or nut oils, etc.

On finding a potential phytochemical for the improvement of cognitive functioning, researchers determine the difference in blood tocopherol levels between patients with Alzheimer's disease (AD) or age-related poor cognitive function and health.

According to the examination of the results of 31 articles that were selected for the meta-analysis, patients with AD or age-related cognitive deficits and mild cognitive impairment (MCI) had lower circulatory concentrations of α-tocopherol compared with healthy controls.

Moreover, levels of β-, γ- and δ-tocopherols did not significantly differ between groups of AD and age-related cognitive deficits compared to controls.

Based on the findings, researchers suggested, "lower α-tocopherol levels have a strong association with AD and MCI supporting evidence for the role of diet and vitamin E in AD risk and age-related cognitive decline".

Taken altogether, tocopherols may be considered a supplement for the prevention and treatment of AD or age-related cognitive deficits and mild cognitive impairment (MCI) caused by vitamin E deficiency, pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.


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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A meta-analysis of peripheral tocopherol levels in age-related cognitive decline and Alzheimer's disease by Ashley S1, Bradburn S1, Murgatroyd C. (PubMed)

Indian Gingsen #Ashwagandha Inhibits the Onset of Hypercholesterolemia, Researchers Say

By Kyle J. Norton

Cholesterol, a waxy substance produced by the liver or the dietary plays a critical role to aid digestive function in absorbing nutrients and fluids, build strong cell membranes, produce steroid hormones and vitamin D. However, excessive amounts of cholesterol in the blood have been found to induce plaque built-up on the arterial wall, leading to hypercholesterolemia, a leading cause of heart disease, and stroke.

Hypercholesterolemia is a condition characterized by abnormally high levels of cholesterol in the bloodstream.

The condition is a result caused by either overexpression of low-density lipoprotein (LDL) or low levels of high-density lipoprotein (HDL).

People with hypercholesterolemia at the early stage are asymptomatic. However, patients with familial hypercholesterol may experience symptoms of chest pain with activity. xanthomas, and cholesterol deposits around the eyelids.

According to the statistics provided by the CDC, hypercholesterolemia is a major risk factor of heart disease, a leading cause of death in the US.

In the US, approximately, 71 million American adults (33.5%) have high low-density lipoprotein (LDL), or “bad,” cholesterol. and only 1 out of every 3 adults with high LDL cholesterol has the condition under control.

Sadly, only 50% of people hypercholesterolemia are getting treatment.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound for the treatment of high blood cholesterol, researchers examined the ashwagandha root extract anti hypercholesteremic effects in an animal model.

Selected hypercholesteremic male albino rats were given root powder of WS added to the diet at 0.75 and 1.5 gm/rat/day.

During the experiment, researchers found that the root powder of WS showed a strong anti-hypercholesteremic activity by significant decreasing levels of total lipids, cholesterol, and triglycerides, in blood plasma.


Furthermore, WS also reduced the levels of cholesterol by a significant increasing plasma HDL-cholesterol levels, HMG-CoA reductase activity and bile acid content of the liver.

Moreover, lipid-peroxidation associated with liver stress was inhibited by WS administration in hypercholesteremic animals, compared to other normal counterparts.

Based on the findings, researchers said, " it appeared that WS root powder is also effective in normal subjects for decreasing lipid profiles".

Taken altogether, Ashwagandha may be considered a functional herb for the treatment of hypercholesterolemia, pending the result of larger sample size and multicenter study


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Hypocholesteremic and antioxidant effects of Withania somnifera (Dunal) in hypercholesteremic rats by Visavadiya NP1, Narasimhacharya AV. (PubMed)

Pancreatin, the Mixture of Amylase, Lipase, and Protease Improves the Absorption of Fat, Protein, and Energy In Patients with Pancreatic Insufficiency

By Kyle J. Norton

The pancreas is an oblong flattened gland in the digestive and endocrine systems located in the abdomen. By secreting pancreatic juice into the small intestine, the pancreas helps to break down carbohydrates, proteins, and lipids.

Traditional Chinese medicine views the pancreas, as a vital organ that is responsible for the absorption of foods' qi and nutrients before passing them to other organs to nourish our body.


More precisely, the functions of the pancreas including
* Production of enzymes digest fat, protein, and
carbohydrates.

* production of juices combined with juices from the intestines helps to do the job of breaking down protein, carbohydrates, and fat, therefore, it plays an important role in maintaining good health.

* Production of insulin, which is important in regulating the amount of sugar or glucose in the blood.

Pancreatic insufficiency is a medical condition in which the pancreas is not able to produce and/or transport enough digestive enzymes to break down food in the intestine.

Two of the most common causes of pancreatic insufficiency (EPI) are cystic fibrosis and chronic pancreatitis.


Other diseases associated with the condition are irritable bowel syndrome (IBS), peptic ulcer disease, gallbladder disease, and inflammatory bowel problems.

Conventionally, depending on the severity of pancreatic insufficiency, the main treatment is to replace the levels of a pancreatic enzyme using pancreatic enzyme replacement therapy, or PERT.



Pancreatin, are a commercial mixture of amylase, lipase, and protease.
In finding a potential phytochemical for the prevention and treatment of pancreatic diseases, researchers elucidated the effects of neutral sterols and short-chain fatty acids on high-lipase pancreatin in Japanese patients with pancreatic insufficiency whose dietary fat consumption is low.

The study included 15 patients with chronic pancreatitis complicated by steatorrhea who consumed an average of 48 g of dietary fats a day and were given 3 g of high-lipase pancreatin (lipase, 379,800 USP U/g), at each meal (the total daily dose is 9 g) for a mean duration of 28.5 days.

According to the fecal output and fecal fat neutral sterol, bile acid, and short-chain fatty acid excretion analysis,
* Pancreatin administration resulted in significant reductions (P < 0.01) in fecal output (from 243.2 to 149.1 g), excretion of fecal fat,

* Furthermore, animal sterols (from 816.3 to 604.6 mg), and short-chain fatty acids were reduced (from 12.3 to 3.9 g), and (from 52.6 to 18.5 mM), respectively.


Interestingly, the administration of pancreatin showed no marked changes in fecal excretion of beta-sitosterol (a plant sterol), bile acids, or the hydroxy fatty acid fraction.

In other words, Pancreatin improved patients with pancreatic insufficiency to absorb fat, protein, and energy.

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of obesity-related chronic inflammation, pending the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of high-lipase pancreatin on fecal fat, neutral sterol, bile acid, and short-chain fatty acid excretion in patients with pancreatic insufficiency resulting from chronic pancreatitis by Nakamura T1, Tandoh Y, Terada A, Yamada N, Watanabe T, Kaji A, Imamura K, Kikuchi H, Suda T. (PubMed)

#Antioxidant #Tocopherols Protect the Elderly Eyes Against the Onset of Age-Related Macular Degeneration, Scientists Say

By Kyle J. Norton

Age-related diseases are medical conditions associated with the increase of age.

Most recently age-related diseases in the elderly are cardiovascular diseases and macular degeneration.

Cardiovascular diseases are a group of conditions triggered by the abnormal function of the heart and blood vessels abnormality.

Age-related macular degeneration is a medical condition that causes irreversible blurring of the central vision in people over age 60.

In other words, AMD may cause significant visual disability.

Most cases of the early stage of AMD were diagnosed during routine eye health examinations.


The elderly at the early stage of age-related macular degeneration is asymptomatic. However, some patients may experience symptoms of slightly blurred central vision. Most cases of the early stage of AMD were diagnosed during routine eye health examinations.

Over time, age-related macular degeneration may affect the vision including the reading as the blurred area increases in size.

Advanced age-related macular degeneration has been found to induce irreversible blindness and visual impairment, according to epidemiological studies.

According to statistics, approximately 11 million people in the US have some form of age-related macular degeneration. The risk of getting advanced age-related macular degeneration increases from 2% for those ages 50-59 to nearly 30% for those over the age of 75.
Besides aging, some researchers suggest that other factors such as smoking, family history, gender, race, sun exposure, diet, and obesity also increase the risk of AMD developing.


Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, seed or nut oils, etc.

On finding a potential phytochemical for the treatment of degenerative diseases, researchers examined the effect of β-, γ-, and δ-tocopherols scavenging free radical and cation radicals of another form of vitamin A-retinal against the onset of age-related macular degeneration.


According to the analysis, β-, γ-, and δ-tocopherols showed a significant in scavenging of cation radicals of retinal, followed by retinoic acid, (0.03 to 5.6) × 109 M-1·s-1, and retinol, (0.08 to 1.6) × 108 M-1·s-1.

Trolox is substantially less efficient at scavenging retinoid cation radicals than α-tocopherol and urate, but it is more efficient at scavenging the cation radicals of retinoic acid and retinol than δ-tocopherol.

These scavenging activities suggest that tocopherols can effectively compete with amino acids and proteins for retinoid cation radicals, thereby protecting these important biomolecules from oxidation.


Based on the results, researchers said, "tocopherols can diminish the oxidative damage to the skin and retina and thereby protect from skin photosensitivity and the development and/or progression of changes in blinding retinal diseases such as Stargardt's disease and age-related macular degeneration (AMD)".

Taken altogether, tocopherols may be considered a supplement for reducing the risk of age-related macular degeneration, pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Scavenging of Retinoid Cation Radicals by Urate, Trolox, and α-, β-, γ-, and δ-Tocopherols by Rozanowska M1,2, Edge R3, Land EJ4, Navaratnam S5, Sarna T6, Truscott TG. (PubMed)

#Healthyfood #Honey Exhibits Anti Hypertension Property with No Side Effects, Scientists Suggest

By Kyle J. Norton

In seeking a natural therapy with no side effects, scientists may have a herbal remedy for normalizing blood pressure, according to studies.

Hypertension is a chronic condition caused by abnormally high blood pressure.

High blood pressure is a condition of a cluster of metabolic syndrome associated with the increased risk of heart disease and stroke.

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.

In high blood pressure individuals, due to the elevated blood pressure in your arteries, the heart has to work harder than normal to pump blood through the blood vessels.

In low blood pressure individuals, the reduced blood pressure in the arteries drops can cause the heart to pump blood at a slower rate than normal.


According to the standard guidelines, the levels of blood pressure are normal if it is more than 120 over 80 and less than 140 over 90 (120/80-140/90).


People with blood pressure lower than 120/80 are considered normal without being accompanied by symptoms of light-head or dizziness.

According to the statistics provided by the CDC, in the U.S. 29% or 100 million adults have hypertension during 2015–2016 and hypertension prevalence increased with age and was 33.2% among those aged 40–59 and 63.1% among those aged 60 and over.


Honey, the rich golden liquid is a miraculous product made by bees using nectar from flowers.

The liquid is considered one of the healthy food for replacing the use of white sugar and artificial sweetener by many people.

Researchers in the course of finding a natural ingredient for the treatment of high blood pressure investigated the safety and effect of intrapulmonary administration (by inhalation) of 60 % honey solution, 10% dextrose, or distilled water in normal or diabetic subjects.

Twenty-four healthy subjects, 16 patients with type 1 diabetes mellitus, and six patients with hypertension were selected to participate in the study.

Twelve healthy subjects were subjected to distilling water inhalation for 10 min, and after one week they received inhalation of honey solution (60% wt/v) for 10 min. Another 12 healthy subjects received inhalation of 10% dextrose for 10 min.

Honey treatment showed a mild reduction of blood pressure compared to no change in another group.

From a time perspective, systolic and diastolic blood pressure was reduced by honey inhalation in hypertensive patients at 60 and 120 min.


After taking into account co and confounders, researchers said, "honey inhalation was safe and effective in reducing...elevated blood pressure in hypertensive patients".

Moreover, in order to obtain more information on honey antihypertensive activity, researchers investigated the aqueous extract obtained from the mixture of the fresh leaf of Persea Americana, stems, and a fresh leaf of Cymbopogon citrus, fruits of Citrus medica, and honey on ethanol and sucrose-induced hypertension in rats.


Rats included in the study were divided into eight groups of 6 rats each and daily treated for 5 weeks. The control group received distilled water (1 mL/kg) while rats of groups 2, 3, and 4 received ethanol 40 degrees (3 g/kg/day), 10% sucrose as drinking water, and the two substances respectively.

The remaining groups received additional sucrose and ethanol, the aqueous extract (50, 100, and 150 mg/kg) or nifedipine (10 mg/kg) respectively.

Group treated with ethanol and sucrose showed a significantly (p < 0.001) increased blood pressure and heart rate compared to distilled water-treated rats.

Chronic treatment of ethanol and sucrose also exerted significantly decreased the activities of antioxidant enzymes produced by the host, observed by the levels of superoxide dismutase (SOD) and catalase (CAT) and elevated levels of oxidative stress observed by the stress marker malondialdehyde (MDA) levels.

However, administration of the aqueous extract or nifedipine prevented all changes caused by chronic ethanol and sucrose, including the hemodynamic, biochemical, oxidative, and histological impairments.

The finding clearly suggested that aqueous extract including honey possesses antihypertensive activity by the improvement of biochemical and oxidative status, through its antioxidant property.

Taken altogether, honey used alone or combined with other herbs may be considered anti-hypertension functional remedies with no side effects, pending the confirmation of a large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Intrapulmonary administration of natural honey solution, hyperosmolar dextrose or hypoosmolar distill water to normal individuals and to patients with type-2 diabetes mellitus or hypertension: their effects on blood glucose level, plasma insulin and C-peptide, blood pressure and peaked expiratory flow rate by Al-Waili N1. (PubMed)
(2) Antihypertensive potential of the aqueous extract which combine leaf of Persea americana Mill. (Lauraceae), stems and leaf of Cymbopogon citratus (D.C) Stapf. (Poaceae), fruits of Citrus medical L. (Rutaceae) as well as honey in ethanol and sucrose experimental model by Dzeufiet PD1, Mogueo A, Bilanda DC, Aboubakar BF, Tédong L, Dimo T, Kamtchouing P. (PubMed)

Phytochemical Beta-Sitosterol in the Prevention of Melanoma Brain Metastases

By Kyle J. Norton

Melanoma is skin cancer caused by the alternation of melanocyte DNA in the skin pigment, leading to the formation of moles that change in the color, size, or shape of the skin.

Most cases of melanoma start in the melanocytes or pigment-producing cells in the outer layer of the skin.

Melanoma-induced metastasis cancer in the brain is secondary cancer as a result of the spreading of melanoma cancer cells.

Melanoma spread to the brain shares the characteristics of melanoma.

Metastasis is a process in which cancer cells travel a distance away from the originated site to induce secondary malignant growths.

Anti-metastasis is an action in which substances or substances are used including herbal medicine to stop the cancer cell to infect other healthy tissues a distance away from the primary tumor.

Most cancer drugs used in conventional medicine with the ability to block the migration of cancer cells are considered to process antimetastatic activity.

Unlike melanoma-induced metastasis in the brain,  brain cancer is a medical and chronic condition characterized by cell growth disorderly in the brain tissue with a small number that may be caused by gene defects from exposure to radiation or toxic chemicals.  More than 190.000 people in the US are diagnosed with a brain tumor each year alone.

More than 190.000 people in the US are diagnosed with a brain tumor each year alone.

Most brain types of brain cancer in older adults aged 50 to 60 are Chordomas. The cancer is rare and slow-growing, but it can invade adjacent bone and put pressure on the nearby neural tissue.

Meningiomas are the most common type of benign brain tumor in the age group 40-50s. However, a small percentage of these tumors can be malignant.

According to the statistic provided by the Canadian cancer society, Every day about 25 Canadians is diagnosed with a brain tumor.

The 5-year survival rate of brain cancer is only 25%, compared to over 60% for cancers overall. Most adults with a diagnosis of aggressive glioblastoma survive only 1–2 years after their diagnosis.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belonging to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, and buckwheat. etc.

On finding a potential phytochemical that processed neuroprotective activity, researchers examined the effect of β-sitosterol on melanoma cell growth in vitro and inhibition of brain metastasis formation.

β-sitosterol exerted mitochondrial interference, against the test cancer cells by reducing the mitochondrial respiratory capacity, mediated by an inhibition of mitochondrial complex I in converting the energy from food for cell needs.

Furthermore, β-sitosterol also increased the expression of oxidative stress to induce cancer cell apoptosis.

These results strongly indicated a significant role of mitochondrial complex I on human melanoma brain metastases compared to brain metastases from other cancers.

Moreover, the combination of vemurafenib with either β-sitosterol or a functional knockdown of mitochondrial complex I showed a completely abrogated BRAF inhibitor resistance in the tested cells.

Based on the findings, researchers said, " β-sitosterol represents a promising adjuvant to BRAF inhibitor therapy in patients with or at risk for, melanoma brain metastases".

Taken altogether, beta-Sitosterol may be considered a functional food for the prevention of melanoma brain metastases, pending the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1)Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brainmetastasis by Sundstrøm T1,2,3, Prestegarden L1,2,4, Azuaje F5,6, Aasen SN1,7, Røsland GV8, Varughese JK1, Bahador M1, Bernatz S9, Braun Y9, Harter PN9, Skaftnesmo KO10, Ingham ES11, Mahakian LM11, Tam S11, Tepper CG12, Petersen K13, Ferrara KW11, Tronstad KJ8, Lund-Johansen M2,3, Beschorner R14, Bjerkvig R1,5, Thorsen F. (PubMed)

Phytochemical γ-Tocopherols Kill Colon Cancer Cells in Vitro

By Kyle J. Norton

The colon is also known as the large intestine.
Colon cancer is relatively very common and slowly growing and progressing in a predictable way.

In most cases of primary colon cancer start in the cell on the surface of the inner lining of the colon. At the early stage. most patients with colon cancer do not experience any symptoms.

However, at the advanced stage, the tumor not only can spread to other healthy tissue and organs a distance away through blood and fluid circulation but also suppress the nearby tissue and nerve cells.

The progression of colon cancer at this stage not only induces symptoms of the change in bowel habits, the change in the consistency of your stool, that lasts longer than four weeks but also causes rectal bleeding and persistent abdominal severe pain.

The most common sites of metastasis for colon or rectal cancer is the liver and lung.

According to the statistic provided by the American Cancer Society, colorectal cancer is the third most common cancer diagnosed in the United States. Every year approximately, 90000 new cases of colon cancer. 43,000 new cases of rectal cancer are diagnosed, leading to the death of 50,000 patients.

The lifetime risk of developing colorectal cancer is about 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.

The 5-year survival rate for patients diagnosed with localized stage colorectal cancer is 90%. About 39% of patients are diagnosed at this early stage.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, seed, or nut oils, etc.

On finding a potential phytochemical for the treatment of malignant tumors, researchers examined the growth inhibitory effects of different forms of tocopherols (T), tocopheryl phosphates (TP), and tocopherol quinones (TQ) on human colon cancer HCT116 and HT29 cells.

According to the analysis, δ-T was more effective in inhibiting colon cancer cell growth, decreasing cancer cell colony formation, and inducing apoptosis, compared to less effective in γ-T and ineffective in α-T.

Furthermore, the γ forms of TP and TQ process the highest inhibiting cancer cell growth, compared to the δ forms and least effective in the α forms.

More precisely, γ-TQ and δ-TQ (showing IC50 values of ∼0.8 and ∼2 μM)  showed significant potencies against the HCT116 cells, after a 72 h incubation with 100-fold and greater than 20-fold higher, respectively.

Moreover, δ-T, γ-TP, and γ-TQ induced cancer cell death were also attributed to the cleavage of caspase 3 involved in apoptosis and PARP1 associated with DNA repair and DNA fragmentation.

Collectively, researchers said, "the higher growth inhibitory activity of δ-T than γ-T, the even higher activities of the γ forms of TP and TQ, and the ineffectiveness of the α forms of tocopherol and their metabolites against colon cancer cells".

Taken altogether, tocopherols may be considered a supplement for the prevention and treatment of colon cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibitory effects of different forms of tocopherols, tocopherol phosphates, and tocopherol quinones on growth of colon cancer cells by Dolfi SC1, Yang Z, Lee MJ, Guan F, Hong J, Yang C
S. (PubMed)