Kyle J. Norton
Hypertension is a condition of abnormally high blood pressure. It also is a member of the cluster of metabolic syndrome associated with the risk of diabetes and cardiovascular disease.
Blood pressure is the force of the blood pushing against the arterial walls. In high blood pressure, the heart has to work harder than normal to pump blood through the circulation system. Over time, high blood pressure has been found to cause damage to the heart and arteries.
High blood pressure can be acute or chronic. Acute high blood pressure most often occurs to people with sudden stress.
Sometimes, it can be caused by intense physical exercise. As the heart must pump harder to provide the needs of nutrients and oxygen.
People with high blood pressure in most cases are asymptomatic.
Most cases of chronic high blood pressure are associated with an unhealthy lifestyle and chronic diseases such as kidney disease, leading to the onset of strokes and cardiovascular disease.
On another hand, If you can control your diet, such as making changes to your lifestyle, maintaining ideal weight, and diet with low salt, you could do just fine without the drugs.
Epidemiologically, here are some natural remedies that will help you to lower high blood pressure, keeping it in the normal range of 130/80.
* Calcium and Magnesium
A combination of these 2 minerals with the right DOSAGES has a long and indisputable track record for normalizing blood pressure safely. Be sure to only take these compounds with a ratio of 2 to 1. Otherwise, this compound might cause an irregular heartbeat.
* Mediterranean diet
A study found that people in Greece and Italy always have ideal blood pressure, because their diet contains more polyunsaturated fat, such as olive oil. If you can replace saturated fat in your diet with extra virgin oil, you could easily normalize your blood pressure.
* Reducing Salt intake
Salt is a mineral composed of sodium and chloride. You need only half a tablespoon a day, but we consume many times more than that every day causing high blood pressure and increasing the risk of early death.
Avoid processed meat, because it has been soaked in salt. Use little Ketchup, mustard, and soy sauce because they contain high amounts of salt.
* Cigarette
If you smoke, you better quit. The nicotine in cigarettes and other tobacco products causes your blood vessels to constrict and your heart to beat faster, which temporarily raises your blood pressure.
* Alcohol
Alcohol might cause a temporary rise in blood pressure in some people. If you have high blood pressure, you should reduce your daily intake of alcohol to 1-2 cups.
* Relaxation
Stress may affect blood pressure. Managing stress, by relaxation techniques, such as yoga, lightweight exercise, aerobic exercise, can be healful.
Lycopene is a phytochemical in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
In finding a natural compound for the treatment of hypertension, researchers examined the tomato carotenoids such as lycopene anti-high blood pressure activity.
The double-blind, randomized, placebo-controlled study included patients with untreated hypertension individuals who received either 5, 15, and 30 mg of lycopene or 15 mg of synthetic lycopene or a placebo over eight weeks.
According to the tested analysis,* The effective doses of Tomato Nutrient Complex (TNC) that maintain normal blood pressure in untreated hypertensive individuals were 15 or 30 mg of lycopene associated with significant reductions in mean systolic blood pressure (SBP) compared to other treatments.
* Furthermore, Treatment with the lower dose standardized for 5 mg of lycopene or treatment with 15 mg of synthetic lycopene showed no significant effect on blood pressure.
* The increase in blood levels of lycopene was dose-dependent.
The results strongly suggested that only the TNC dose of 15 mg lycopene or higher has a beneficial effect on SBP in hypertension.
Taken together, lycopene found in tomatoes may be considered a supplement for the prevention and treatment of hypertension, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of Tomato Nutrient Complex on Blood Pressure: A Double Blind, Randomized Dose⁻Response Study by Wolak T1, Sharoni Y2, Levy J3, Linnewiel-Hermoni K4, Stepensky D5, Paran E. (PubMed)
(2) Lycopene and Vascular Health by Mozos I1,2, Stoian D3, Caraba A4, Malainer C5, Horbańczuk JO6, Atanasov AG. (PubMed)
Tuesday 21 November 2023
#Phytochemical Allyl isothiocyanate #AITC Induces Brain and Bladder Cancer Cell Apoptosis, According to Studies
Kyle J. Norton
Phytochemical Allyl isothiocyanate may be the next pharmacotherapeutic target to identify the chemo drug for the treatment of brain cancer without inducing any side effects.
Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color.
The brain and spinal cord make up the nervous system. Brain and Spinal Cord tumors originating are not very common.
Brain cancer is a medical and chronic condition characterized by cell growth disorderly in the brain tissue.
Benign tumors are noncancerous, and malignant tumors are cancerous. More than 190.000 people in the US are diagnosed with a brain tumor each year alone.
Most brain types of brain cancer in older adults ages 50 to 60 are Chordomas. The cancer is a rare and slow-growing, but it can invade adjacent bone and put pressure on the nearby neural tissue.
Meningiomas, are the most common type of benign brain tumor of the age group 40-50s. However, a small percentage of these tumors can be malignant.
According to the statistic provided by the Canadian Cancer Society, Every day about 25 Canadians is diagnosed with a brain tumor.
The 5-year survival rate of brain cancer is only 25%, compared to over 60% for cancers overall. Most adults with a diagnosis of aggressive glioblastoma survive only 1–2 years after their diagnosis.
The exact causes of brain cancer are debatable. Researchers do not know why people with the same health conditions, and family history, are at a higher risk to develop brain cancer while others do not.
Some researchers suggested genetic preposition and acquired gene mutation due to long-term exposure to chemical toxins may be the prevalent risk factor that causes the alternation of brain cell DNA.
The most common symptoms of brain cancer depending on the stage are persistent headaches and localized pain, gradual loss of sensation and movement, speech difficulty, and persistent pain
If you are experiencing some of the above symptoms, please make sure you check with your doctor immediately to rule the brain cancer possibility.
Allyl isothiocyanate is a phytochemical containing sulfur in the class of organosulfur compounds, found abundantly in horseradish, mustard, wasabi, etc.
Most primary tumors are caused by abnormal cell growth that surrounds and supports neurons, with a small number that may be caused by a gene defect from exposure to radiation or toxic chemicals.
Examining the side effects of Allyl isothiocyanate from the available data suggests that urinary concentrations of AITC equivalent are at least ten times higher than in the plasma, and tissue levels of AITC equivalent in the urinary bladder were 14-79 times higher than in other organs after oral AITC administration to rats for the treatment of cancer.
These results indicated AITC may be most effective in the bladder as a cancer chemopreventive compound, as AITC at high-dose levels exhibited a low degree of cytotoxicity and genotoxicity in animal cancer studies.
Once again, the experiment reaffirmed the effect of AITC in the exhibition of many desirable attributes of a cancer chemopreventive agent.
In the reassessment of Allyl isothiocyanate (AITC) in the reduced risk of cancer, researchers at the National Chung Hsing University conducted an experiment to examine the effects of the phytochemical in brain cancer cells.
Compared to other cancer cell lines inhibition, AITC significantly decreased proliferation and viability of human brain malignant glioma GBM 8401 cells in a dose-dependent manner with IC50 9.25+/-0.69 microM for 24 h-treatment.
In cell differentiated assay, AITC induced significantly G2/M arrest and sub-G1 phase (apoptotic population) in GBM 8401 cells.
AITC markedly reduced the CDK1/cyclin B activity and protein levels which are responsible for cancer cell proliferation and survival.
Furthermore, AITC-induced apoptotic cell death through enhancing the proteins associated with cells death programming.
Dr. Chen NG, the lead scientist at the final report, said, "AITC is a potent anti-human brain malignant glioma drug and it shows a remarkable action on cell cycle arrest before a commitment for apoptosis is reached".
Taken together, it is safe to suggest that Phytochemical Allyl isothiocyanate may be used as a chemopreventive and functional phytochemical for high-risk brain cancer individuals and an adjunct therapy combined with primary medicine for the treatment of brain cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To ProfessionalPrediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Allyl isothiocyanate triggers G2/M phase arrest and apoptosis in human brain malignant glioma GBM 8401 cells through a mitochondria-dependent pathway by Chen NG, Chen KT, Lu CC, Lan YH, Lai CH, Chung YT, Yang JS, Lin YC. (PubMed)
(2) Allyl isothiocyanate as a cancer chemopreventive phytochemical by Zhang Y.(PubMed)
Phytochemical Allyl isothiocyanate may be the next pharmacotherapeutic target to identify the chemo drug for the treatment of brain cancer without inducing any side effects.
Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color.
The brain and spinal cord make up the nervous system. Brain and Spinal Cord tumors originating are not very common.
Brain cancer is a medical and chronic condition characterized by cell growth disorderly in the brain tissue.
Benign tumors are noncancerous, and malignant tumors are cancerous. More than 190.000 people in the US are diagnosed with a brain tumor each year alone.
Most brain types of brain cancer in older adults ages 50 to 60 are Chordomas. The cancer is a rare and slow-growing, but it can invade adjacent bone and put pressure on the nearby neural tissue.
Meningiomas, are the most common type of benign brain tumor of the age group 40-50s. However, a small percentage of these tumors can be malignant.
According to the statistic provided by the Canadian Cancer Society, Every day about 25 Canadians is diagnosed with a brain tumor.
The 5-year survival rate of brain cancer is only 25%, compared to over 60% for cancers overall. Most adults with a diagnosis of aggressive glioblastoma survive only 1–2 years after their diagnosis.
The exact causes of brain cancer are debatable. Researchers do not know why people with the same health conditions, and family history, are at a higher risk to develop brain cancer while others do not.
Some researchers suggested genetic preposition and acquired gene mutation due to long-term exposure to chemical toxins may be the prevalent risk factor that causes the alternation of brain cell DNA.
The most common symptoms of brain cancer depending on the stage are persistent headaches and localized pain, gradual loss of sensation and movement, speech difficulty, and persistent pain
If you are experiencing some of the above symptoms, please make sure you check with your doctor immediately to rule the brain cancer possibility.
Allyl isothiocyanate is a phytochemical containing sulfur in the class of organosulfur compounds, found abundantly in horseradish, mustard, wasabi, etc.
Most primary tumors are caused by abnormal cell growth that surrounds and supports neurons, with a small number that may be caused by a gene defect from exposure to radiation or toxic chemicals.
Examining the side effects of Allyl isothiocyanate from the available data suggests that urinary concentrations of AITC equivalent are at least ten times higher than in the plasma, and tissue levels of AITC equivalent in the urinary bladder were 14-79 times higher than in other organs after oral AITC administration to rats for the treatment of cancer.
These results indicated AITC may be most effective in the bladder as a cancer chemopreventive compound, as AITC at high-dose levels exhibited a low degree of cytotoxicity and genotoxicity in animal cancer studies.
Once again, the experiment reaffirmed the effect of AITC in the exhibition of many desirable attributes of a cancer chemopreventive agent.
In the reassessment of Allyl isothiocyanate (AITC) in the reduced risk of cancer, researchers at the National Chung Hsing University conducted an experiment to examine the effects of the phytochemical in brain cancer cells.
Compared to other cancer cell lines inhibition, AITC significantly decreased proliferation and viability of human brain malignant glioma GBM 8401 cells in a dose-dependent manner with IC50 9.25+/-0.69 microM for 24 h-treatment.
In cell differentiated assay, AITC induced significantly G2/M arrest and sub-G1 phase (apoptotic population) in GBM 8401 cells.
AITC markedly reduced the CDK1/cyclin B activity and protein levels which are responsible for cancer cell proliferation and survival.
Furthermore, AITC-induced apoptotic cell death through enhancing the proteins associated with cells death programming.
Dr. Chen NG, the lead scientist at the final report, said, "AITC is a potent anti-human brain malignant glioma drug and it shows a remarkable action on cell cycle arrest before a commitment for apoptosis is reached".
Taken together, it is safe to suggest that Phytochemical Allyl isothiocyanate may be used as a chemopreventive and functional phytochemical for high-risk brain cancer individuals and an adjunct therapy combined with primary medicine for the treatment of brain cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To ProfessionalPrediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Allyl isothiocyanate triggers G2/M phase arrest and apoptosis in human brain malignant glioma GBM 8401 cells through a mitochondria-dependent pathway by Chen NG, Chen KT, Lu CC, Lan YH, Lai CH, Chung YT, Yang JS, Lin YC. (PubMed)
(2) Allyl isothiocyanate as a cancer chemopreventive phytochemical by Zhang Y.(PubMed)
#CruciferousVegetables and Celecoxib Modulates Oncogenic Activity Against the Onset of #BladderCancer, Researchers Say
Kyle J. Norton
Allyl isothiocyanate is a phytochemical containing sulfur in the class of organosulfur compounds, found abundantly in horseradish, mustard, wasabi, etc.
The bladder is a hollow elastic organ in the center of the lower abdomen that collects urine from the kidneys and excretes it through the urethra.
Bladder cancer is the most common type of cancer that affects men twice as frequently as it affects women. Usually, it starts from the bladder lining caused by several types of malignant growths of the urinary bladder cells.
The study of AITC found cruciferous vegetables and celecoxib effects in modulating cyclooxygenase-2 (Cox-2), as its oncogenic activity has been well documented in bladder cancer and other cancers, this effectiveness is a result of associated with depletion of prostaglandin E2, a key downstream signaling molecule of Cox-2, caspase activation and downregulation of vascular endothelial growth factor in the tumor tissues.
In another study, the N-acetylcysteine conjugate (NAC-AITC) is found to be a significant inhibition of cell growth and proliferation in human bladder cancer UM-UC-3 cells or rat bladder cancer AY-27 cells with NAC-AITC at 15 μM.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
References
1. Enhanced inhibition of urinary bladder cancer growth and muscle invasion by allyl isothiocyanate and celecoxib in combination by Bhattacharya A, Li Y, Shi Y, Zhang Y(PubMed)
(2) The principal urinary metabolite of allyl isothiocyanate, N-acetyl-S-(N-allylthiocarbamoyl)cysteine, inhibits the growth and muscle invasion of bladder cancer by Bhattacharya A, Li Y, Geng F, Munday R, Zhang Y.(PubMed)
Allyl isothiocyanate is a phytochemical containing sulfur in the class of organosulfur compounds, found abundantly in horseradish, mustard, wasabi, etc.
The bladder is a hollow elastic organ in the center of the lower abdomen that collects urine from the kidneys and excretes it through the urethra.
Bladder cancer is the most common type of cancer that affects men twice as frequently as it affects women. Usually, it starts from the bladder lining caused by several types of malignant growths of the urinary bladder cells.
The study of AITC found cruciferous vegetables and celecoxib effects in modulating cyclooxygenase-2 (Cox-2), as its oncogenic activity has been well documented in bladder cancer and other cancers, this effectiveness is a result of associated with depletion of prostaglandin E2, a key downstream signaling molecule of Cox-2, caspase activation and downregulation of vascular endothelial growth factor in the tumor tissues.
In another study, the N-acetylcysteine conjugate (NAC-AITC) is found to be a significant inhibition of cell growth and proliferation in human bladder cancer UM-UC-3 cells or rat bladder cancer AY-27 cells with NAC-AITC at 15 μM.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
References
1. Enhanced inhibition of urinary bladder cancer growth and muscle invasion by allyl isothiocyanate and celecoxib in combination by Bhattacharya A, Li Y, Shi Y, Zhang Y(PubMed)
(2) The principal urinary metabolite of allyl isothiocyanate, N-acetyl-S-(N-allylthiocarbamoyl)cysteine, inhibits the growth and muscle invasion of bladder cancer by Bhattacharya A, Li Y, Geng F, Munday R, Zhang Y.(PubMed)
Friday 17 November 2023
#GreenPeas (Pisum Sativum) Supplementation Ameliorates the Risk and Severity of #Colitis, Researchers Say
Kyle J. Norton
Colitis is a general term associated with the inflammation of the inner lining of the colon.
The disease can be caused by infection, inflammatory bowel disease (Crohn's disease (CD), ulcerative colitis(CD)), ischemic colitis, allergic reactions, and microscopic colitis.
Most cases of colitis are involved in the damage of the intestinal mucosal barrier, particularly to those of ulcerative colitis.
Epidemiologically, damage and a reduction of gut bacteria by dietary chemicals, such as antibiotics of the protective mucus layer and the underlying tissue by the poorly inactivated digestive proteases have been found to induce both UC and CD.
The intestinal mucosal barrier is the outermost inner layer of the lining of the intestines which plays an essential role in ensuring the adequate containment of undesirable luminal contents within the intestine while preserving the ability to absorb nutrients.
Additionally, the intestinal mucosal barrier also processes various immunological mediators, including cytokines and chemokines stimulated by gut microbiota and host immune responses, thus maintaining a well-balanced relationship between gut microbes and the host immune system.
In other words, the intestinal mucosal barrier protects the colonic integrity by interacting with the gut microbiota and the immune response to prevent the inflammation of the colon that causes the onset of colitis.
Some researchers suggested the promotion of a high-fat diet over the past few decades may be one of the most prevalent factors that increase the risk of colitis.
Dr. Max Gulhane, the lead scientist wrote, "Prolonged high-fat diets (HFD) induce low-grade chronic intestinal inflammation in mice, and diets high in saturated fat are a risk factor for the development of human inflammatory bowel diseases".
And, "HFD-induced endoplasmic reticulum (ER)/oxidative stress occur in intestinal secretory goblet cells, triggering inflammatory signaling and reducing synthesis/secretion of proteins that form the protective mucus barrier".
The finding strongly suggested the mucosal barrier dysfunction induced by a high-fat diet involved in colitis.
Green peas are a species of Pisum Sativum belonging to the family Fabaceae and native to western Asia from the Mediterranean Sea to the Himalayan Mountains. The pea is a green, pod-shaped vegetable and a cool-season crop grown in many parts of the world.
In finding a potent ingredient that processes anti-inflammatory activity with oxidative stress, researchers investigated the impact of green pea (GP) supplementation on the susceptibility of a high-fat diet (HFD) in an animal model.
The study included Six-week-old C57BL/6J female mice randomly assigned into groups fed a 45% HFD or HFD supplemented with 10% GP. After 7-week dietary supplementation, colitis induced by adding 2.5% DSS in drinking water for 7 days followed by a 7-day recovery period.
According to the tested analysis, GP supplementation ameliorated the disease activity index score in HFD-fed mice by reducing the expression of pro-inflammatory cytokines.
Furthermore, inflammatory markers associated with inflammatory proteins and enzymes such as interleukin (IL)-6, cyclooxygenase-2 (COX-2), IL-17, interferon-γ (IFN-γ), and inducible nitric oxide synthase (iNOS) in HFD-fed mice were also decreased by GP supplement.
Goblet cell differentiation markers in HFD-fed mice. associated with mucus secretion and function during the stage of inflammation were also increased by the administration of GP supplementation.
Furthermore, endoplasmic reticulum (er) stress-induced production of pro-inflammatory cytokines in HFD-fed mice was also inhibited by GP supplement.
Based on the findings, researchers wrote, "GP supplementation ameliorated the severity of DSS-induced colitis in HFD-fed mice, which was associated with the suppression of inflammation, mucin depletion, and ER stress in the colon".
Taken together, green peas may be considered a functional food for the prevention and treatment of colitis, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary Green Pea Protects against DSS-Induced Colitis in Mice Challenged with High-Fat Diet by Bibi S1, de Sousa Moraes LF2, Lebow N3, Zhu MJ. (PubMed)
(2) High Fat Diets Induce Colonic Epithelial Cell Stress and Inflammation that is Reversed by IL-22 by Max Gulhane,1 Lydia Murray,1 Rohan Lourie,1 Hui Tong,1 Yong H. Sheng,1 Ran Wang,1 Alicia Kang,2Veronika Schreiber,1 Kuan Yau Wong,1 Graham Magor,3 Stuart Denman,4 Jakob Begun,1 Timothy H. Florin,1Andrew Perkins,3 Páraic Ó. Cuív,2 Michael A. McGuckin,1 and Sumaira Z. Hasnaina. (PMC)
Colitis is a general term associated with the inflammation of the inner lining of the colon.
The disease can be caused by infection, inflammatory bowel disease (Crohn's disease (CD), ulcerative colitis(CD)), ischemic colitis, allergic reactions, and microscopic colitis.
Most cases of colitis are involved in the damage of the intestinal mucosal barrier, particularly to those of ulcerative colitis.
Epidemiologically, damage and a reduction of gut bacteria by dietary chemicals, such as antibiotics of the protective mucus layer and the underlying tissue by the poorly inactivated digestive proteases have been found to induce both UC and CD.
The intestinal mucosal barrier is the outermost inner layer of the lining of the intestines which plays an essential role in ensuring the adequate containment of undesirable luminal contents within the intestine while preserving the ability to absorb nutrients.
Additionally, the intestinal mucosal barrier also processes various immunological mediators, including cytokines and chemokines stimulated by gut microbiota and host immune responses, thus maintaining a well-balanced relationship between gut microbes and the host immune system.
In other words, the intestinal mucosal barrier protects the colonic integrity by interacting with the gut microbiota and the immune response to prevent the inflammation of the colon that causes the onset of colitis.
Some researchers suggested the promotion of a high-fat diet over the past few decades may be one of the most prevalent factors that increase the risk of colitis.
Dr. Max Gulhane, the lead scientist wrote, "Prolonged high-fat diets (HFD) induce low-grade chronic intestinal inflammation in mice, and diets high in saturated fat are a risk factor for the development of human inflammatory bowel diseases".
And, "HFD-induced endoplasmic reticulum (ER)/oxidative stress occur in intestinal secretory goblet cells, triggering inflammatory signaling and reducing synthesis/secretion of proteins that form the protective mucus barrier".
The finding strongly suggested the mucosal barrier dysfunction induced by a high-fat diet involved in colitis.
Green peas are a species of Pisum Sativum belonging to the family Fabaceae and native to western Asia from the Mediterranean Sea to the Himalayan Mountains. The pea is a green, pod-shaped vegetable and a cool-season crop grown in many parts of the world.
In finding a potent ingredient that processes anti-inflammatory activity with oxidative stress, researchers investigated the impact of green pea (GP) supplementation on the susceptibility of a high-fat diet (HFD) in an animal model.
The study included Six-week-old C57BL/6J female mice randomly assigned into groups fed a 45% HFD or HFD supplemented with 10% GP. After 7-week dietary supplementation, colitis induced by adding 2.5% DSS in drinking water for 7 days followed by a 7-day recovery period.
According to the tested analysis, GP supplementation ameliorated the disease activity index score in HFD-fed mice by reducing the expression of pro-inflammatory cytokines.
Furthermore, inflammatory markers associated with inflammatory proteins and enzymes such as interleukin (IL)-6, cyclooxygenase-2 (COX-2), IL-17, interferon-γ (IFN-γ), and inducible nitric oxide synthase (iNOS) in HFD-fed mice were also decreased by GP supplement.
Goblet cell differentiation markers in HFD-fed mice. associated with mucus secretion and function during the stage of inflammation were also increased by the administration of GP supplementation.
Furthermore, endoplasmic reticulum (er) stress-induced production of pro-inflammatory cytokines in HFD-fed mice was also inhibited by GP supplement.
Based on the findings, researchers wrote, "GP supplementation ameliorated the severity of DSS-induced colitis in HFD-fed mice, which was associated with the suppression of inflammation, mucin depletion, and ER stress in the colon".
Taken together, green peas may be considered a functional food for the prevention and treatment of colitis, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary Green Pea Protects against DSS-Induced Colitis in Mice Challenged with High-Fat Diet by Bibi S1, de Sousa Moraes LF2, Lebow N3, Zhu MJ. (PubMed)
(2) High Fat Diets Induce Colonic Epithelial Cell Stress and Inflammation that is Reversed by IL-22 by Max Gulhane,1 Lydia Murray,1 Rohan Lourie,1 Hui Tong,1 Yong H. Sheng,1 Ran Wang,1 Alicia Kang,2Veronika Schreiber,1 Kuan Yau Wong,1 Graham Magor,3 Stuart Denman,4 Jakob Begun,1 Timothy H. Florin,1Andrew Perkins,3 Páraic Ó. Cuív,2 Michael A. McGuckin,1 and Sumaira Z. Hasnaina. (PMC)
Regular Intake of #Onion Is Associated with a Reduced Risk of #Cancer, According to Studies
Kyle J. Norton
Cancer is a group of medical conditions caused by irregular cell growth in the tissues and organs due to the alternation of cell DNA.
Most cases of cancer start in the cells on the surface of the inner lining of the infected tissue or argan before penetrating into the deeper layers to form a tumor.
Certain factors have been found to affect prognosis including
* The type of cancer and where it is in your body
*The stage of cancer, most often refers to the size and metastasis of cancer.
** Stage 0
Cancer is classified as Stage 0 if the cancerous cell has not penetrated deeper tissue but on the surface of the inner lining.
** Stage I
In stage I, The cancerous cells are no longer in the surface but have invaded the deep lung lining, but still completely inside the lung.
***Stage IA1
The cancer is ≤ 3 mm (1/8 inch) deep and ≤ 7 mm (1/4 inch) wide.
**** Stage IA1: The spreading is < 3mm(1/8 inch) deep and & less than 7mm (1/4 inch) wide.
**** Stage IA2: The invasion area is ≥ 3 mm but ≤ 5 mm (about 1/5 inch) deep and & less than 7 mm (about 1/4 inch) wide.
***. Stage IB: cancer in this stage has invaded the connective tissue, & less than 5mm (1/5 inch).
**** Stage IB1: Cancer is 4 cm large (1 3/4 inches).
**** Stage IB2: Cancer is ≥ 4 cm (1 3/4 inches) but & less than 5cm (1/5 inch)
**Stage II
In stage II, the cancerous cells have spread to distant tissues but are still within the organ.
**Stage III
At this stage, cancerous cells have spread to the tissues immediately surrounding the organ.
**Stage IV
The stage, IV is the most advanced stage of cancer as cancerous cells have spread to distant parts of the body
In this stage, cancerous cells have spread to the tissues immediately surrounding the organ.
* Cancer’s grade, low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancer indicates otherwise.
* Certain traits of cancer cells include
** How cancer cell stimulates their own growth
** How cancer cells resist inhibitory signals that stop their growth
** How cancer cells inhibit programmed cell death signaling.
Some researchers also include the age, health of patients, and how patients responded to previous cancer treatment
The onion is a plant in the genus Allium, belonging to the family Alliaceae, closely related to garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
To find a potential compound for the treatment of cancer, researchers examined the effect of garlic and onion on certain types of cancer.
Intake of onion is found inversely associated with the risk of onions or garlic and cancers of the oral cavity/pharynx, larynx, renal cells, breast, ovary, and endometrium.
More precisely, people who eat onions ≥7 times/week have the OR of oral cavity/pharyngeal cancers of 0.16, laryngeal cancer of 0.17, and ovarian cancer of 0.27 compared to those who did not eat onions.
Furthermore, according to the study of cases from the Hawaii Tumor Registry and controls randomly selected from a list of Oahu residents, intake of onion was associated with decreased risk of lung cancer with the OR = 0.5 in the highest quartile of intake compared to the lowest.
In prostate cancer, the Italian study suggested that both onions and garlic did not have significantly decreased OR of prostate cancer compared to those with the lowest intake, However, increasing intake showed a trend of decreasing the ORs.
In esophageal cancer, the intake of raw garlic/onion at least once per week has the adjusted OR of esophageal cancer of 0.2.
In colorectal cancer, the Italian and Swiss case-control studies found that both onions show a protective effect against colon cancer regardless of the amount of intake onion intake compared to non-consumers of onion.
In stomach cancer, according to the meta-analysis, consumption of large amounts of total Allium vegetables, such as garlic and onion reduced the risk of gastric cancer by comparing the highest and lowest consumption groups.
Taken together, onion may be considered a remedy for cancer prevention, pending confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Garlic and onions: Their cancer prevention properties by Holly L. Nicastro,1 Sharon A. Ross,2 and John A. Milner. (PubMed)
(2) Understanding Cancer Prognosis (NIH)
Cancer is a group of medical conditions caused by irregular cell growth in the tissues and organs due to the alternation of cell DNA.
Most cases of cancer start in the cells on the surface of the inner lining of the infected tissue or argan before penetrating into the deeper layers to form a tumor.
Certain factors have been found to affect prognosis including
* The type of cancer and where it is in your body
*The stage of cancer, most often refers to the size and metastasis of cancer.
** Stage 0
Cancer is classified as Stage 0 if the cancerous cell has not penetrated deeper tissue but on the surface of the inner lining.
** Stage I
In stage I, The cancerous cells are no longer in the surface but have invaded the deep lung lining, but still completely inside the lung.
***Stage IA1
The cancer is ≤ 3 mm (1/8 inch) deep and ≤ 7 mm (1/4 inch) wide.
**** Stage IA1: The spreading is < 3mm(1/8 inch) deep and & less than 7mm (1/4 inch) wide.
**** Stage IA2: The invasion area is ≥ 3 mm but ≤ 5 mm (about 1/5 inch) deep and & less than 7 mm (about 1/4 inch) wide.
***. Stage IB: cancer in this stage has invaded the connective tissue, & less than 5mm (1/5 inch).
**** Stage IB1: Cancer is 4 cm large (1 3/4 inches).
**** Stage IB2: Cancer is ≥ 4 cm (1 3/4 inches) but & less than 5cm (1/5 inch)
**Stage II
In stage II, the cancerous cells have spread to distant tissues but are still within the organ.
**Stage III
At this stage, cancerous cells have spread to the tissues immediately surrounding the organ.
**Stage IV
The stage, IV is the most advanced stage of cancer as cancerous cells have spread to distant parts of the body
In this stage, cancerous cells have spread to the tissues immediately surrounding the organ.
* Cancer’s grade, low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancer indicates otherwise.
* Certain traits of cancer cells include
** How cancer cell stimulates their own growth
** How cancer cells resist inhibitory signals that stop their growth
** How cancer cells inhibit programmed cell death signaling.
Some researchers also include the age, health of patients, and how patients responded to previous cancer treatment
The onion is a plant in the genus Allium, belonging to the family Alliaceae, closely related to garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
To find a potential compound for the treatment of cancer, researchers examined the effect of garlic and onion on certain types of cancer.
Intake of onion is found inversely associated with the risk of onions or garlic and cancers of the oral cavity/pharynx, larynx, renal cells, breast, ovary, and endometrium.
More precisely, people who eat onions ≥7 times/week have the OR of oral cavity/pharyngeal cancers of 0.16, laryngeal cancer of 0.17, and ovarian cancer of 0.27 compared to those who did not eat onions.
Furthermore, according to the study of cases from the Hawaii Tumor Registry and controls randomly selected from a list of Oahu residents, intake of onion was associated with decreased risk of lung cancer with the OR = 0.5 in the highest quartile of intake compared to the lowest.
In prostate cancer, the Italian study suggested that both onions and garlic did not have significantly decreased OR of prostate cancer compared to those with the lowest intake, However, increasing intake showed a trend of decreasing the ORs.
In esophageal cancer, the intake of raw garlic/onion at least once per week has the adjusted OR of esophageal cancer of 0.2.
In colorectal cancer, the Italian and Swiss case-control studies found that both onions show a protective effect against colon cancer regardless of the amount of intake onion intake compared to non-consumers of onion.
In stomach cancer, according to the meta-analysis, consumption of large amounts of total Allium vegetables, such as garlic and onion reduced the risk of gastric cancer by comparing the highest and lowest consumption groups.
Taken together, onion may be considered a remedy for cancer prevention, pending confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Garlic and onions: Their cancer prevention properties by Holly L. Nicastro,1 Sharon A. Ross,2 and John A. Milner. (PubMed)
(2) Understanding Cancer Prognosis (NIH)
Wednesday 8 November 2023
#Phytochemical #Betacyanins Reduce Chemo-Drug Toxicity and Overcome Multidrug Resistance of Cancer Cells, Researchers Say
Kyle J. Norton
Cancer is a class of disease characterized by cell growth disorderly and uncontrollably in the tissues and organs.
The most common cancers are
* Breast cancer, accounted for 25.4% of the total number of new cases diagnosed in 2018.
Breast cancer starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. there are also rare cases of breast cancer that start in other areas of the breast. The risk of getting invasive breast cancer during the lifetime of women is 1/8.
Luckily, the 5 years survival rate of localized breast cancer is about 100%.
* Colorectal cancer and lung cancers are the second and third most common cancers, accounting for 43.9% of all cancers, excluding non-melanoma skin cancer.
Colorectal cancer is cancer in the colon, rectum, or vermiform appendix. Colorectal cancer is a relatively very common and slowly growing and progressing cancer.
The 5-year survival rate of the localized stage of colorectal cancer is about 90%.
Lung cancer is a condition of the abnormal growth of the cells in the lung's tissue. The most common form of primary lung cancer is derived from epithelial cells.
Lung cancer can also be classified into
* Non-small cell lung cancer
Non-small cell lung cancer is the most common type of lung cancer. It usually grows and spreads methodically and predictably.
* Small cell lung cancer
Small cell lung cancer is a fast-growing type of lung cancer, it can spread to distant parts of the body in a relatively early stage.
The overall 5-year survival rate of lung cancer is about 60%.
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
In the finding, of the health benefits of Betacyanins, researchers compared the effect of green beet (Beta vulgaris var. cicla L.) and red beetroot (B. vulgaris var. Rubra L.) phytochemicals that benefit human health.
According to the chemical analysis, green beet contains apigenin, vitexin, vitexin-2-O-xyloside, and vitexin-2-O-rhamnoside, compared to the red beetroot as a source of betaxanthins and betacyanins.
All phytochemicals found in green and red beet show considerable antioxidant, anti-inflammatory, and antiproliferative activities.
From a cancer perspective, vitexin-2-O-xyloside combined with betaxanthins and betacyanins, exerts a significant antiproliferative activity in breast, liver, colon, and bladder cancer cell lines, through the induction of cancer cell apoptosis.
Additionally, betacyanins and other phytochemicals found in the green and red beet inhibited the pro-survival and anti-apoptotic genes, and modulated proteins associated with angiogenesis.
Moreover, betaxanthins and betacyanins used in combination with conventional anticancer drugs were found to reduce chemo-drug toxicity and overcome the multidrug resistance of cancer cells.
Based on the findings, researchers concluded betacyanins may be used alone or combined with other phytochemicals or chemo drugs to block the onset of the proliferation of tumor cells.
Taken together, betacyanins may be considered a remedy for the prevention and treatment of cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) C-Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer and Antiinflammatory Activities-A Review by Ninfali P1, Antonini E1, Frati A1, Scarpa ES. (PubMed)
Cancer is a class of disease characterized by cell growth disorderly and uncontrollably in the tissues and organs.
The most common cancers are
* Breast cancer, accounted for 25.4% of the total number of new cases diagnosed in 2018.
Breast cancer starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. there are also rare cases of breast cancer that start in other areas of the breast. The risk of getting invasive breast cancer during the lifetime of women is 1/8.
Luckily, the 5 years survival rate of localized breast cancer is about 100%.
* Colorectal cancer and lung cancers are the second and third most common cancers, accounting for 43.9% of all cancers, excluding non-melanoma skin cancer.
Colorectal cancer is cancer in the colon, rectum, or vermiform appendix. Colorectal cancer is a relatively very common and slowly growing and progressing cancer.
The 5-year survival rate of the localized stage of colorectal cancer is about 90%.
Lung cancer is a condition of the abnormal growth of the cells in the lung's tissue. The most common form of primary lung cancer is derived from epithelial cells.
Lung cancer can also be classified into
* Non-small cell lung cancer
Non-small cell lung cancer is the most common type of lung cancer. It usually grows and spreads methodically and predictably.
* Small cell lung cancer
Small cell lung cancer is a fast-growing type of lung cancer, it can spread to distant parts of the body in a relatively early stage.
The overall 5-year survival rate of lung cancer is about 60%.
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
In the finding, of the health benefits of Betacyanins, researchers compared the effect of green beet (Beta vulgaris var. cicla L.) and red beetroot (B. vulgaris var. Rubra L.) phytochemicals that benefit human health.
According to the chemical analysis, green beet contains apigenin, vitexin, vitexin-2-O-xyloside, and vitexin-2-O-rhamnoside, compared to the red beetroot as a source of betaxanthins and betacyanins.
All phytochemicals found in green and red beet show considerable antioxidant, anti-inflammatory, and antiproliferative activities.
From a cancer perspective, vitexin-2-O-xyloside combined with betaxanthins and betacyanins, exerts a significant antiproliferative activity in breast, liver, colon, and bladder cancer cell lines, through the induction of cancer cell apoptosis.
Additionally, betacyanins and other phytochemicals found in the green and red beet inhibited the pro-survival and anti-apoptotic genes, and modulated proteins associated with angiogenesis.
Moreover, betaxanthins and betacyanins used in combination with conventional anticancer drugs were found to reduce chemo-drug toxicity and overcome the multidrug resistance of cancer cells.
Based on the findings, researchers concluded betacyanins may be used alone or combined with other phytochemicals or chemo drugs to block the onset of the proliferation of tumor cells.
Taken together, betacyanins may be considered a remedy for the prevention and treatment of cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) C-Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer and Antiinflammatory Activities-A Review by Ninfali P1, Antonini E1, Frati A1, Scarpa ES. (PubMed)
#Healthyfood #Papaya Controls Glucose and Reduces the Risk of Complications in Diabetics, Researchers Say
Kyle J. Norton
Papaya may be the next generation of whole foods for the prevention and treatment of type II diabetes with no side effects, some studies suggested.
Diabetes is a condition characterized by insufficient insulin entering the bloodstream to regulate glucose.
Most cases of type II diabetes are either caused by cells in the pancreas that died off or receptor sites clogged up by fat and cholesterol.
In some cases, diabetes is also caused by allergic reactions of cells in the immune system.
Epidemiological studies suggested that obesity, family history, ethnicity, the increase in age, gestation diabetes, and polycystic ovary syndrome. and high blood pressure is the most common risk factor associated with the onset of prediabetes and type II diabetes.
Dr. Stephen S. Rich, in the article "the genetics of Diabetes and Its complications", suggested that type II diabetes may be a genetically related disease. Unlike type 1 diabetes, in which there seems to be an autoimmune process, type 2 diabetes is a disease of relative rather than absolute insulin deficiency. Genes involved in type 2 diabetes, with the most promising, replicated findings on chromosomes are 1q21-q24, 2q37, 12q24, and 20.
Untreated and unmanageable type II diabetes may induce complications of the onset of cardiovascular disease, and nerve damage (neuropathy). kidney damage (nephropathy), eye damage (retinopathy). foot damage and skin conditions.
Medication used for the treatment of type II diabetes is focused on alleviating the symptoms improving quality of life and slowing down the progression of the disease.
If you currently intake medicine for the treatment of diabetes, please sure you know all the side effects for the preventive measure.
Papaya is a species of Carica Papaya, belonging to the family Caricaceae and native to the tropics of the Americas, and was first cultivated in Mexico several centuries
Unripe pawpaw fruit (Carica papaya) not only inhibited α-amylase, and α-glucosidase but also reduced lipid peroxidation in a dose-dependent manner, in rat pancreas(1).
The key enzymes of α-amylase, α-glucosidase, involved in the digestion of carbohydrates, have been linked to the onset of type 2 diabetes. Inhibition of these enzymes can significantly reduce the postprandial increase of blood glucose and has been used for the management of blood glucose levels in type 2 diabetic and borderline patients by therapists (2).
In the streptozotocin-induced diabetic rats study, the aqueous extract of leaves of C. papaya administered strongly controlled blood glucose levels(3), through the prevention of hepatocyte disruption, as well as accumulation of glycogen and lipids via its hypoglycemic and antioxidant effect(4)
In a new study, conducted by researchers at the Davis Heart and Lung Research Institute, fermented papaya preparation was tested whether it improves dermal wound healing outcomes in adult diabetic mice by preventing the risk of infections(5).
The result was astonishing, the fermentation not only up-regulated the Sp1 DNA binding activity(modulating the cellular response to DNA damage) in Peripheral blood mononuclear cells (PBMC) but also the protein and mRNA expression of Rac2(regulates several cellular functions)(5).
A randomized controlled clinical trial conducted at the Cardiac Centre, ANDI Centre of Excellence for Biomedical and Biomaterials Research and Department of the Biosciences University of Mauritius, suggested that oral administration of 6g FPP®/day for 14 weeks could improve the general health status of several organs targeted by oxidative stress during diabetes and the supplement may be used in the management the complications of diabetes such as cardiovascular disease, neurological disease and other conditions worsened by overt inflammation and oxidative stress(6).
Taken together, unripe, fermented papaya and its' leaves may be effective in diabetic management by controlling the levels of glucose and reducing the risk of complications.
Some Western researchers insisted that large sample sizes and multicenter studies are necessary to validate its effectiveness by identifying the ingredients that are comparable to recent pharmaceutical medicine in use because geography, environment, time of harvest, etc. may influence the concentration of the food cultivation.
In fact, herbalists have long acknowledged that the external factors (mentioned above) may alter the quality of the herbs and foods by classifying these differences either through price or formula differentiation.
Indeed, the effectiveness with little or no adverse side effects of the formula is not the concentration of individual herbs and the herb itself but the interaction of all ingredients in an herb and herbs in the same formula. Extracting only one ingredient of the herb for the treatment of certain diseases may be effective but enhance complicated consequences.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.References
(1) Inhibition of key enzymes linked to type 2 diabetes and sodium nitroprusside-induced lipid peroxidation in rat pancreas by water-extractable phytochemicals from unripe pawpaw fruit (Carica papaya) by Oboh G, Olabiyi AA, Akinyemi AJ, Ademiluyi AO. (PubMed)
(2) Natural products as alpha-amylase and alpha-glucosidase inhibitors and their hypoglycaemic potential in the treatment of diabetes: an update by Tundis R1, Loizzo MR, Menichini F.(PubMed)
(3) Antihyperglycemic and hypolipidemic activities of aqueous extract of Carica papaya Linn. leaves in alloxan-induced diabetic rats by Maniyar Y, Bhixavatimath P.(PubMed)
(4) Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats by Juárez-Rojop IE1, Díaz-Zagoya JC, Ble-Castillo JL, Miranda-Osorio PH, Castell-Rodríguez AE, Tovilla-Zárate CA, Rodríguez-Hernández A, Aguilar-Mariscal H, Ramón-Frías T, Bermúdez-Ocaña DY.(PubMed)
(5) Correction of aberrant NADPH oxidase activity in blood-derived mononuclear cells from type II diabetes mellitus patients by a naturally fermented papaya preparation by Dickerson R1, Deshpande B, Gnyawali U, Lynch D, Gordillo GM, Schuster D, Osei K, Roy S.(PubMed)
(6) Effects of a short term supplementation of a fermented papayapreparation on biomarkers of diabetes mellitus in a randomized Mauritian population by Somanah J1, Aruoma OI, Gunness TK, Kowelssur S, Dambala V, Murad F, Googoolye K, Daus D, Indelicato J, Bourdon E, Bahorun T.(PubMed)
(6) Genetics of Diabetes and Its Complications by Stephen S. Rich
Papaya may be the next generation of whole foods for the prevention and treatment of type II diabetes with no side effects, some studies suggested.
Diabetes is a condition characterized by insufficient insulin entering the bloodstream to regulate glucose.
Most cases of type II diabetes are either caused by cells in the pancreas that died off or receptor sites clogged up by fat and cholesterol.
In some cases, diabetes is also caused by allergic reactions of cells in the immune system.
Epidemiological studies suggested that obesity, family history, ethnicity, the increase in age, gestation diabetes, and polycystic ovary syndrome. and high blood pressure is the most common risk factor associated with the onset of prediabetes and type II diabetes.
Dr. Stephen S. Rich, in the article "the genetics of Diabetes and Its complications", suggested that type II diabetes may be a genetically related disease. Unlike type 1 diabetes, in which there seems to be an autoimmune process, type 2 diabetes is a disease of relative rather than absolute insulin deficiency. Genes involved in type 2 diabetes, with the most promising, replicated findings on chromosomes are 1q21-q24, 2q37, 12q24, and 20.
Untreated and unmanageable type II diabetes may induce complications of the onset of cardiovascular disease, and nerve damage (neuropathy). kidney damage (nephropathy), eye damage (retinopathy). foot damage and skin conditions.
Medication used for the treatment of type II diabetes is focused on alleviating the symptoms improving quality of life and slowing down the progression of the disease.
If you currently intake medicine for the treatment of diabetes, please sure you know all the side effects for the preventive measure.
Papaya is a species of Carica Papaya, belonging to the family Caricaceae and native to the tropics of the Americas, and was first cultivated in Mexico several centuries
Unripe pawpaw fruit (Carica papaya) not only inhibited α-amylase, and α-glucosidase but also reduced lipid peroxidation in a dose-dependent manner, in rat pancreas(1).
The key enzymes of α-amylase, α-glucosidase, involved in the digestion of carbohydrates, have been linked to the onset of type 2 diabetes. Inhibition of these enzymes can significantly reduce the postprandial increase of blood glucose and has been used for the management of blood glucose levels in type 2 diabetic and borderline patients by therapists (2).
In the streptozotocin-induced diabetic rats study, the aqueous extract of leaves of C. papaya administered strongly controlled blood glucose levels(3), through the prevention of hepatocyte disruption, as well as accumulation of glycogen and lipids via its hypoglycemic and antioxidant effect(4)
In a new study, conducted by researchers at the Davis Heart and Lung Research Institute, fermented papaya preparation was tested whether it improves dermal wound healing outcomes in adult diabetic mice by preventing the risk of infections(5).
The result was astonishing, the fermentation not only up-regulated the Sp1 DNA binding activity(modulating the cellular response to DNA damage) in Peripheral blood mononuclear cells (PBMC) but also the protein and mRNA expression of Rac2(regulates several cellular functions)(5).
A randomized controlled clinical trial conducted at the Cardiac Centre, ANDI Centre of Excellence for Biomedical and Biomaterials Research and Department of the Biosciences University of Mauritius, suggested that oral administration of 6g FPP®/day for 14 weeks could improve the general health status of several organs targeted by oxidative stress during diabetes and the supplement may be used in the management the complications of diabetes such as cardiovascular disease, neurological disease and other conditions worsened by overt inflammation and oxidative stress(6).
Taken together, unripe, fermented papaya and its' leaves may be effective in diabetic management by controlling the levels of glucose and reducing the risk of complications.
Some Western researchers insisted that large sample sizes and multicenter studies are necessary to validate its effectiveness by identifying the ingredients that are comparable to recent pharmaceutical medicine in use because geography, environment, time of harvest, etc. may influence the concentration of the food cultivation.
In fact, herbalists have long acknowledged that the external factors (mentioned above) may alter the quality of the herbs and foods by classifying these differences either through price or formula differentiation.
Indeed, the effectiveness with little or no adverse side effects of the formula is not the concentration of individual herbs and the herb itself but the interaction of all ingredients in an herb and herbs in the same formula. Extracting only one ingredient of the herb for the treatment of certain diseases may be effective but enhance complicated consequences.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.References
(1) Inhibition of key enzymes linked to type 2 diabetes and sodium nitroprusside-induced lipid peroxidation in rat pancreas by water-extractable phytochemicals from unripe pawpaw fruit (Carica papaya) by Oboh G, Olabiyi AA, Akinyemi AJ, Ademiluyi AO. (PubMed)
(2) Natural products as alpha-amylase and alpha-glucosidase inhibitors and their hypoglycaemic potential in the treatment of diabetes: an update by Tundis R1, Loizzo MR, Menichini F.(PubMed)
(3) Antihyperglycemic and hypolipidemic activities of aqueous extract of Carica papaya Linn. leaves in alloxan-induced diabetic rats by Maniyar Y, Bhixavatimath P.(PubMed)
(4) Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats by Juárez-Rojop IE1, Díaz-Zagoya JC, Ble-Castillo JL, Miranda-Osorio PH, Castell-Rodríguez AE, Tovilla-Zárate CA, Rodríguez-Hernández A, Aguilar-Mariscal H, Ramón-Frías T, Bermúdez-Ocaña DY.(PubMed)
(5) Correction of aberrant NADPH oxidase activity in blood-derived mononuclear cells from type II diabetes mellitus patients by a naturally fermented papaya preparation by Dickerson R1, Deshpande B, Gnyawali U, Lynch D, Gordillo GM, Schuster D, Osei K, Roy S.(PubMed)
(6) Effects of a short term supplementation of a fermented papayapreparation on biomarkers of diabetes mellitus in a randomized Mauritian population by Somanah J1, Aruoma OI, Gunness TK, Kowelssur S, Dambala V, Murad F, Googoolye K, Daus D, Indelicato J, Bourdon E, Bahorun T.(PubMed)
(6) Genetics of Diabetes and Its Complications by Stephen S. Rich
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