Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals : April 2019

Tuesday, 30 April 2019

Turmeric Protects the Nerves Against the Onset of Diabetic Neuropathy

By Kyle J. Norton

Diabetic neuropathy is a complication of patients with diabetes associated with nerves damage, ranging from pain and numbness in your legs and feet to problems with your digestive system.

Most cases of diabetic neuropathy are involved in diabetics who have a history of hyperglycemia caused by long-term high levels of glucose in the bloodstream, urinary tract, blood vessels, and heart.

Diabetic neuropathy can be classified into 4 main types, including.

* Peripheral neuropathy is the most common type of diabetic neuropathy, affecting the nerves that control the feet and legs first, followed by the hands and arms.

* The autonomic neuropathy that affects the nerves that control the heart, bladder, stomach, intestines, sex organs and eyes.

* Radiculoplexus neuropathy found mostly in older patients affects nerves that control the thighs, hips, buttocks or legs.

* Mononeuropathy, or focal neuropathy also found commonly in older patients affects the nerves that control the face, middle of the body (torso) or leg.

The exact causes of diabetic neuropathy are totally depending on the type of neuropathy. However, damage of nerves and blood vessels in the affected area has been found to induce by over time, uncontrolled high blood sugar.

In other words, diabetic neuropathy is preventable by keeping the blood glucose in the healthy range.

Dr. Michael Greger M.D. FACLM in the article "the best diet for diabetic neuropathy" wrote, "
(By examing) people eating different diets found that nine months or more on a strict plant-based diet appeared to remove the trans fat from their bodies (or at least their butts). Their pain, however, didn’t take nine months to get better—it got better in days".

In the explanation of the results, the researcher continued, "More likely, it was due to an improvement in blood flow. “[N]erve biopsies in diabetics with severe progressive neuropathy…have shown small vessel disease within the nerve.” There are blood vessels within our nerves that can get clogged up too. The oxygen levels in the nerves of diabetics were found to be lower than even the levels of de-oxygenated blood".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In the urgency to find a potential ingredient for the treatment of diabetic neuropathy researchers examined the turmeric antioxidant property, anti-inflammatory, CNS depressant effect, antibacterial and antifungal property.

According to the results of the experiment, turmeric inhibited the pathogenesis of diabetic neuropathy by improving the antioxidant in the reduction of the level of oxidative stress associated with the occurrence of the present complication.

Furthermore, turmeric also enhanced the anti-inflammatory and antibacterial activity against the spread of infection.

In other words, turmeric inhibited diabetic neuropathy through a number of mechanisms involved in the antioxidant, anti-inflammatory and antibacterial activity.

In order to review more information about turmeric effect, researchers investigated Nishamalaki (NA), a combination of Curcuma longa and Emblica officinalis in the prevention of diabetic neuropathy.

The study included diabetic neuropathy in type 2 diabetic Wistar rats under treatment of 12 weeks.

Selected rats were randomly divided into group I (Control) vehicle treated consists of 6 rats and

group II-VII Diabetic Control, NA low dose, NA High dose, Glibenclamide, Pioglitazone and Epalrestat respectively.

Diabetes-induced in 36 Wistar rats with Streptozotocin (STZ) (35mg/kg) intraperitoneally followed by High Fat High Fructose diet. After confirmation of the development of diabetes; rats divided into six groups as the aforementioned division.

Compared to other treatment groups, Nishamalaki (NA) not only controlled hyperglycemia and reduced lipid levels but also effectively prevented the development of diabetic neuropathy.

Taken altogether, turmeric used alone or combined with other herbal medicine may be considered supplements for the prevention of diabetic neuropathy, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

(1) Investigation of the utility of Curcuma caesia in the treatment of diabetic neuropathy by Grover M1, Shah K2, Khullar G3, Gupta J1, Behl T. (PubMed)

(2) Evaluation of Effect of Nishamalaki on STZ and HFHF Diet Induced Diabetic Neuropathy in Wistar Rats by Dawane JS1, Pandit VA2, Bhosale MS3, Khatavkar PS. (PubMed)

(3) Best Diet for Diabetic Neuropathy. Written By Michael Greger M.D. FACLM on January 1st, 2019

Phytochemical Betanin, the Potent Anti Prostate Cancer Remedy

By Kyle J. Norton

Prostate cancer is a medical condition associated with cell growth disorderly in the tissue of the prostate.

The prostate is a reproductive gland in men that have shape and size of a walnut located between the bladder and the penis found in front of the rectum.

The gland has a unique function in the making of prostate fluid, one of the components of semen.

Prostate cancer is one of the slowest growth of cancer in men. Prostate cancer may take years to develop before affecting the patients with symptoms.

Most cases of prostate cancer are found in older men. However,
The disease also affects men before the ages of 40.

Believe it or not, about 1 man in 9 will be diagnosed with prostate cancer during his lifetime. According to the statistics, about 6 cases in 10 are diagnosed in men aged 65 or older.

In the US, approximately 1,700,000 new cases are diagnosed every year. Prostate cancer also causes the death of 609,640 patients.

The 5-year survival rate for diagnosed at local or regional prostate cancer is nearly 100%.

Although there are many risk factors involved in the onset of the condition, some researchers suggested the widespread prostate cancer over the past few decades may correlate to the promotion of a high-fat diet in the US.

Dr. Amir Bagheri, the lead scientists in the cancer team wrote, "Prostate cancer is one of the most common types of cancer with a high mortality rate".

And, "After adjustment for potential confounders, a healthy dietary pattern was associated with decreased risk of prostate cancer (highest versus lowest tertile OR:0.24; 95% CI: 0.07-0.81; trend p: 0.025). An unhealthy dietary pattern was related to increased risk of prostate cancer(highest versus lowest tertile OR:3.4; 95% CI: 1.09-10.32; trend p: 0.037)".

The findings strongly suggested that men who follow the Western diet pattern are associated with an increased risk of prostate cancer compared to those who do not.

Betanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to find an effective compound for the treatment of prostate cancer, researchers compared the cytotoxic effect of the red beetroot extract with an anticancer drug, doxorubicin (Adriamycin) in the androgen-independent human prostate cancer cells (PC-3).

According to the tested assays, both doxorubicin and the beetroot extract exhibited similarly a dose-dependent cytotoxic effect in the two cancer cell lines.

The cytotoxicity of the beetroot extract was significantly lower when compared to doxorubicin, however, the extract continued to decrease the growth rate of the PC-3 cells by 3.7% in 3 days vs. 12.5% in 7 days at the concentration of 29 µg/ml, compared to those of doxorubicin, at the same concentration level.

In further analysis, researchers found that the anti-prostate cancer effects of beetroot extract were attributed to the presence of betanin, the major betacyanin constituent in the exhibition of cytotoxicity.

Dr. Kapadia GJ, the lead scientists suggested the beetroot extract (B) when used alone or in combination with doxorubicin (D) may process chemopreventive potentials to mitigate the toxic side-effects of the latter.

In order to reveal more information of red beetroot (Beta vulgaris L.) anti-cancer activity researchers examined the beetroot extract (B), approved by Food and Drug Administration and European Union as red food color E162 against cancers.

In pancreatic (PaCa), breast (MCF-7) and prostate (PC-3) tumor cells of human origin, D showed an overall positive reduction in drug concentration when combined with B in its cytotoxicity profile.

The synergistic cytotoxicity was best when the B:D ratio of 1:5 was used in PaCa cells at IC50, IC75, and IC90 dose levels.

The findings strongly supported the potential use of red beetroot extract-doxorubicin combination in treating human prostate cancer.

In other words, red beetroot extracts not only processed the potential to improve the anti-cancer effects of doxorubicin through reduced volume used in prostate cancer treatment but also inhibited the doxorubicin's adverse effects.

Taken altogether, betanin used alone or combined with other medicines may be considered supplements for the prevention and treatment of prostate cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of betanin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancercell lines by Kapadia GJ1, Azuine MA, Rao GS, Arai T, Iida A, Tokuda H. (PubMed)

(2) Synergistic cytotoxicity of red beetroot (Beta vulgaris L.) extract with doxorubicin in human pancreatic, breast and prostate cancer cell lines by Kapadia GJ1, Rao GS, Ramachandran C, Iida A, Suzuki N, Tokuda H. (PubMed)

(3) Dietary patterns and risk of prostate cancer: a factor analysis study in a sample of Iranian men by Amir Bagheri, 1 , 2 Seyed Mostafa Nachvak, 1 ,* Mansour Rezaei, 3 Mozhgan Moravridzade, 1 , 2Mahmoudreza Moradi, 4 and Michael Nelson. (PMC)

Bromelain Protects the Inner Lining of Colon Against Colitis

By Kyle J. Norton

Colitis is a medical condition associated with the inflammation of the inner lining of the colon.

The causes of colitis can be results of infection, inflammatory bowel disease, including Crohn's disease and ulcerative colitis, ischemic colitis, allergic reactions, and microscopic colitis.

Most common systems of colitis are total depending on the types of condition, including abdominal pain, cramping, diarrhea, with or without blood in the stool.

Some patients with colitis also experience symptoms of fever, chills, fatigue, dehydration, eye inflammation.

If you have some of the aforementioned symptoms, please check with your doctor to rule out the possibility.

According to the statistics, in the US, 1.6 million Americans are living with inflammatory bowel disease, about 907,000 of them have ulcerative colitis.

Also, according to the study by the Catholic University of the Sacred Heart, the most common types of colitis include

* Microscopic colitis is an inflammation of the large intestine (colon) that causes persistent watery diarrhea.

* Ischemic colitis is inflammation and injury of the large intestine that results from the inadequate blood supply.

* Segmental colitis is an inflammation of the colonic luminal mucosa.

* Radiation enteritis is inflammation of the intestines caused by radiotherapy.

* Diversion colitis is an inflammation of the colon associated with the complication of ileostomy or colostomy.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and for the treatment of pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

On finding a natural compound for the treatment of colitis, researchers examined whether long-term dietary supplementation with pineapple (supplied as juice) could decrease colon inflammation in neoplasia in Il10(-/-) mice with chronic colitis, compared to bromelain derived from the stem.

The experiment included colitis Il10(-/-) mice induced by exposure to the non-steroidal anti-inflammatory drug piroxicam followed by supplemented with fresh vs. boiled pineapple juice or bromelain purified (14 mg bromelain) from the stem for up to 6 months.

During the study, daily treatment of fresh juice had a decreased histologic colon inflammation scores and a lower incidence of inflammation scores, compared to those treated with bromelain purified (14 mg bromelain).

Futhermore, both treatments showed fewer neoplastic lesions/colon. However, fresh juice lower incidence of inflammation-associated colonic neoplasia by 35% compared to 66% of those treated with bromelain purified (14 mg bromelain).

According to the flow cytometric analysis of murine splenocytes in vitro, fresh pineapple juice demonstrated a proteolytic removal of cell surface molecules that can affect leukocyte trafficking and activation, compared to those treated with bromelain purified.

The finding strongly supported the long-term use of pineapple juice with proteolytically active bromelain enzymes for the treatment of inflammatory induction of colitis.

Dr. Hale LP, the lead scientist wrote in the final report, "long-term dietary supplementation with fresh or unpasteurized frozen pineapple juice with proteolytically active bromelain enzymes is safe and decreases inflammation severity and the incidence and multiplicity of inflammation-associated colonic neoplasia in this commonly used murine model of inflammatory bowel disease".

Taken altogether, pineapple (supplied as juice) processed a high amount of bioactive compound bromelain may be considered supplements for the prevention and treatment of colitis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources
(1) Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease by Hale LP1, Greer PK, Trinh CT, Gottfried MR. (PubMed)
(2) Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis by Hale LP1, Chichlowski M, Trinh CT, Greer PK. (PubMed)

Plant-Based Alliin, the Potential Anti Ovarian Cancer Phytochemical

By Kyle J. Norton

Ovarian cancer is a chronic and medical condition caused by cell growth irregularly in the tissue of the ovary.

Most cases of ovarian cancer begin in the cells on the surface of the inner lining tissue of the ovary before spreading to the deeper layers to form a tumor.

In the very early stage, due to the very small size of the tumor, most patients are asymptomatic. However, as the disease progression, patients may experience symptoms shared commonly with other types of cancer accompanied by specific symptoms of abdominal bloating or swelling, discomfort in the pelvis area, changes in bowel habits, such as constipation.

According to the statistics provided by the American Cancer Society, ovarian cancer ranks fifth in cancer deaths among women, accounting for more deaths than any other cancer of the female reproductive system.

A woman risk of ovarian cancer is 1 in 78. and the risk of the lifetime chance of dying from ovarian cancer is about 1 in 108.

The five-year relative survival rate for all types and stages of ovarian cancer is 47 percent, Cancer diagnosed at the early stage have a 5-year survival rate of over 72%.

The exact causes of ovarian cancer are not known. However, according to the epidemiological studies genetics preposition such as BRCA1 and BRCA2, family and history of cancer or endometriosis, aging, reproductive history, and infertility and obesity are some of the prevalent factors involved in the onset of ovarian cancer.

The Canadian Cancer Society in the evaluation of the risk of ovarian cancer in women who are never being pregnant or giving birth wrote, "Women who have never been pregnant have a higher risk of developing ovarian cancer than women who have been pregnant".

And, "Researchers think that the lower risk may be because the hormones that are present during pregnancy have a protective effect. It is possible that the higher risk in women who have never been pregnant is linked to the factors that may make it difficult for her to become pregnant".

In other words, women who have at least one pregnancy are at a lower risk of ovarian cancer compared to women who do not.

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide, a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

With an aim to find a natural and potential compound for the treatment of ovarian cancer without inducing adverse effects, researchers examined the efficacy of preparation including chemical conjugate between daidzein and the garlic enzyme alliinase.

According to the tested assays, the conjugate specifically bound to ovarian cancer cells and upon addition of the prodrug alliin by inducing the cytotoxic allicin molecules in killing the cancer cells.

In vivo, the preparation showed a targeting and antitumor effect confirmed by NIR and bioluminescence imagine in the luciferase-expression of ovarian cancer cells.

Treatment of ovarian tumor-bearing mice with daidzein-alliinase and alliin effectively attenuated tumor progression during the first 12 days.

Compared to placebo, only small individual foci of luminescence at the site of tumor cells inoculation was found in the treatment group, according to autopsy.

Interestingly, the preparation did not reveal any additional foci of carcinoma or signs of toxicity, according to the histological examination of organs and tissues.

In other words, the chemical conjugate between daidzein and the garlic enzyme alliinase induced ovarian cancer cells apoptosis through its cytotoxic effects without causing harm to the nearby healthy cells.

Based on the findings researchers wrote in the final report, "the targeted alliinase conjugates in the presence of alliin, generated therapeutically effective levels of allicin which were capable of suppressing tumor progression of intraperitoneal ovarian cancer in an animal model".

Taken altogether, alliin used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of ovarian cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Conjugates of daidzein-alliinase as a targeted pro-drug enzyme system against ovarian carcinoma by Appel E1, Rabinkov A, Neeman M, Kohen F, Mirelman D. (PubMed)
(2) Risk factors for ovarian cancer by the Canadian Cancer Society

Sunday, 28 April 2019

Herbal Bilberry Enhances the Gut Microbiota for Healthy Aging

By Kyle J. Norton

Aging is the natural and biological process of growing older.

You can not stop the aging clock, but, you can delay the progression by taking some preventive actions, including living a healthy lifestyle accompanied by moderate exercise.

Healthy aging refers to the creation of a series of conditions that allow the aging population to live functionally without affected by serious chronic diseases or medical conditions (that are well managed).

The World Health Organization in the definition of healthy aging wrote, "healthy aging as the process of developing and maintaining the functional ability that enables wellbeing in older age” and "Functional ability is about having the capabilities that enable all people to be and do what they have reason to value".

In other words, healthy aging must comprise all the mental and physical capacities such as the ability to walk, think, see, hear and remember, particularly in bathing, dressing, and other independent living skills, such as shopping and housework.

Dr. Ruth Elaine Nieuwenhuis-Mark in the study of healthy aging as a disease wrote, "A popular theory in the aging literature since the early 1990s is the socioemotional selectivity theory (SST; Carstensen, 1992). SST was put forward as an attempt to explain the so-called “paradox of aging” which refers to the finding that while physical health tends to decline as we age subjective well-being may be maintained or even improve (Diener and Suh, 1998)".

And, "Focusing on normal aging as a disease could, therefore, be seen as a step-back for aging research rather than a move forward. Aging-as-disease proponents would argue however that their focus is on improving quality of life in our final years, not on increasing our lifespans per se".

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Researchers in an aim to a natural compound which processes antiaging property examined the effects of bilberry anthocyanin extract consumption in healthy aging and intestinal barrier function and digestive enzyme activity, through regulating the gut microbiota in aging rats.

The study included aging rats fed with the medium-dose bilberry anthocyanin extract (20 mg per kg bw per day) in the regulation of the intestinal function.

Consumption of the extract showed strong activity in the gut by allowing the bacteria beneficial in the intestine (Aspergillus oryzae, Lactobacillus, Bacteroides, Clostridiaceae-1, the Bacteroidales-S24-7-group, and the Lachnospiraceae_NK4A136_group) to grow, and inhibiting the growth of harmful bacteria (Verrucomicrobia and Euryarchaeota).

However, high-dose bilberry anthocyanin extract consumption was found to induce the negative effect in alternating some intestinally beneficial bacteria.

Furthermore, bilberry anthocyanin extract consumption also decreased the activity of digestive enzymes in breaking down food correlated to the changes in bacterial composition, short-chain fatty acids and the intestinal mucosal barrier.

In other words, bilberry anthocyanin extract consumption improved the digestive function without affecting the digestive enzymes activity which has been found in low levels in people with the digestive problem including the aging population.

Dr. Li J, the lead scientists said, " bilberry anthocyanin extract consumption is a potential approach for assisting healthy aging".

The finding suggested that bilberry anthocyanin extract has a significant anti-aging effect by optimizing the function of the digestive system through wide range mechanisms, including bacterial composition.

Taken altogether, bilberry processed abundantly bioactive compound anthocyanin may be considered an anti-aging remedy, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Bilberry anthocyanin extract promotes intestinal barrier function and inhibits digestive enzyme activity by regulating the gut microbiota in aging rats by Li J1, Wu T1, Li N1, Wang X1, Chen G1, Lyu X1. (PubMed)
(2) The senescence-accelerated mouse-prone 8 is not a suitable model for the investigation of cardiac inflammation and oxidative stress and their modulation by dietary phytochemicals by Schiborr C1, Schwamm D, Kocher A, Rimbach G, Eckert GP, Frank J. (PubMed)
(3) Healthy Aging as Disease? by Ruth Elaine Nieuwenhuis-Mark. (PubMed)
(4) What is Healthy Ageing? (WHO)

Whole Food Honey Speeds Up Wound Healing

By Kyle J. Norton

The wound can be internal or external. It is a cut or open of skin or injury of tissues caused by the physical impacts.

Human all have the experience of an open wound at some point in their life. Most wounds are minor. However, if the opening wound that lasts more than 20 minutes and causes a loss of a large pool of blood can be an emergency.

Wounds can be classified into 4 types

* An abrasion is a wound caused by rubbing or scraping the skin against a rough or hard surface.

* A laceration is a cut or tearing of your skin in most cases caused by knives, tools accidentally.

* Puncture is a hole caused by a sharp object, due to its strong impact, puncture has been found to induce tissue damage

* An avulsion is the most serious case of wound that induces a partial or complete tearing away of skin and the tissue beneath.

Not all wounds are the same if the wound cause bleeding longer than 20 minutes and deeper than 1/2 inches, you have to go to the emergency right the way.

In some cases, longer wound bleeding is also associated with the intake of certain medications such as blood thinner.

Treatment of a wound in conventional medicine is to reduce pain and prevent infection. Do not expect the doctor to provide you with medicine that speeds up the wound healing.

Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.

The liquid is considered one of the healthy food for replacing the use of white sugar and artificial sweetener by many people.

On finding natural products for speed-up wound healing, researchers examined the honey in the contribution to its beneficial properties, especially in the wound healing process.

Stingless bee honey exerted a significant activity in breaking down the chain of free radicals that cause a detrimental effect to the wounded area through its antioxidant property.

The stingless bee honey sped up wound healing by protecting the wound against bacterial contamination through its antimicrobial property.

Furthermore, the tested honey also protected the wound dealing process by inhibiting the inflammation induced cytotoxicity.

Moreover, the tested honey promoted angiogenesis and oxygen circulation by its moisturizing properties.

Based on the results, researchers wrote, "The application of honey to the wound has been widely used since ancient times. As a result, it is essential to understand the pharmacological mechanism of the honey towards the physiology of the wounded skin in order to optimize the healing rate in the future".

Additionally, in order to learn more information about honey wound healing effects, researchers evaluated the effects of honey in the healing of skin wounds and particularly chronic wounds, such as diabetic foot ulcers.

Amongst the five tested honey, BL1 and BL5 honey showed the most promising healing properties due to the presence of flavanol that is already known to possess interesting biological activities.

Taken altogether, honey processed a high amount of flavanol may be considered a functional remedies for the promotion of wound healing with no side effects, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Stingless Bee Honey, the Natural Wound Healer: A Review by Abd Jalil MA1, Kasmuri AR, Hadi H. (PubMed)
(2) Evaluation of the In Vitro Wound-Healing Activity of Calabrian Honeys by Governa P1, Carullo G2, Biagi M3, Rago V4, Aiello F. (PubMed)

Herbal Artichoke Regulates Insulinemic Response

By Kyle J. Norton

Insulin response is a process of your body that react to the dietary intake.

Insulin produced by the pancreas is a hormone that binds the insulin receptors in the promotion of cell of the intestines to convert glucose to energy for the body needs.

Acute insulin response used as the predictor of types 2 diabetes by diagnosed both normal fasting and 2-h plasma glucose concentrations.

Compared to a healthy individual with normal insulin response, most patients of prediabetes and diabetes have elevated fasting and 2 hours of plasma glucose concentration.

There are many risk factors associated with the abnormal insulinemic response. However, some researchers suggested that the gradual dying of the beta cells of pancreas and insulin receptors sites clogging-up by cholesterol are 2 of the major causes that affect the insulin expression.

Some researchers suggested that abnormal insulin response may be correlated to the widespread of obesity that leads to insulin resistance in the Western world.

Dr. Olga T. Hardy, in the evaluation of the causes of insulin resistance underlying obesity wrote,

"The association between obesity and insulin resistance is an area of much interest and enormous public health impact".

And, "Visceral adiposity is correlated with the accumulation of excess lipid in the liver and results in cell-autonomous impairment in insulin signaling. Visceral adipose tissue is also prone to inflammation and inflammatory cytokine production, which also contribute to impairment in insulin signaling".

The results strongly suggested if you are obese, your risk of insulin resistance increased substantially compared to overweight or healthy weight individuals.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Researchers on finding a potential natural ingredient for the modulation of insulinemic response, researchers investigate the impact of the supplementation of a pre-biotic compound [Jerusalem artichoke meal (JAM)] on the glycaemic and insulinemic response in healthy, non-obese warm-blooded horses.

The study included 6 adult mares fed with crushed oat grains (1 g starch/kg bwt per day) and meadow hay (2 kg/100 kg bwt per day) together with either 0.15 g fructooligosaccharides and inulin (FOS+INU)/kg bwt per day via commercial JAM or maize cob meal without grains as control (CON) in 2 × 3-week periods according to a crossover design.

According to the sample collected at the postprandial (PP) time points (-60, 0, 30, 60, 90, 120, 180, 240 and 300 min), and the plasma glucose and serum insulin levels, JAM vs. CON did not change the PP peak of glucose or insulin (glucose: 6.3 ± 0.40 vs. 7.0 ± 0.87 mmol/l.

However, following JAM feeding, glucose and insulin levels declined more rapidly until 240 min PP compared to animal fed with CON.

The finding suggested that JAM exerted a significant effect on postprandial (PP) glucose and insulin levels on and after the time points of 240 min.

Furthermore, in order to reveal more information JA insulinemic response, researchers compared the Jerusalem artichoke (Helianthus tuberosus Linne, HTL) and chungkookjang (CKJ; fermented soybeans) in energy and glucose metabolism.

The study included rats divided into partially pancreatectomized (Px) diabetic rats, and sham-operated non-diabetic control rats and all fed high-fat diets. Additionally, diabetic rats were sub-divided into an untreated diabetic control group and those fed with 5% HTL, 5% CKJ or 5% HTL+5% CKJ for 8 weeks. HTL+CKJ treatment reduced visceral fat without modulating energy intake compared to diabetic control.

According to the hyperinsulinemic euglycemic assay, rats treated HTL, HTL+CKJ showed an improvement in glucose tolerance, compared to the diabetic normal-control group.

CKJ and CKJ+HTL but not HTL, injection groups increased first and second phase insulin secretion compared to that of diabetic-control.

Moreover, the glucose infusion rates (mg/kg bw/min) and hepatic insulin sensitivity were increased and CKJ+HTL (13.5), but not HTL (9.4) or CKJ (9.5) alone, and HTL and CKJ+ HTL decreased hepatic glucose compared to diabetic control.

Dr. Yang HJ, the lead scientist wrote in the final report, "HTL and CKJ enhanced glucose tolerance in different manners, and exhibited partially additive and complementary effects by reversing insulin resistance and enhancing β-cell function in diabetic rats".

Taken altogether, artichoke used alone or combined with another herbal remedy may be considered functional food for the enhancement of insulinemic response against the onset of diabetes, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Glycaemic and insulinaemic responses of adult healthy warm-blooded mares following feeding with Jerusalem artichoke meal by Glatter M1, Bochnia M1, Goetz F1, Gottschalk J2, Koeller G3, Mielenz N4, Hillegeist D5, Greef JM5, Einspanier A2, Zeyner A. (PubMed)
(2) Jerusalem artichoke and chungkookjang additively improve insulin secretion and sensitivity in diabetic rats by Yang HJ1, Kwon DY, Kim MJ, Kang S, Kim DS, Park S. (PubMed)
(3) What causes the insulin resistance underlying obesity? by Olga T. Hardy, Michael P. Czech, and Silvia Corvera. (PMC)

Whole Food Ginger, the Stroke Prevention Functional Remedy

By Kyle J. Norton

Stroke is a medical condition characterized by the death of brain cells as a result of inadequate of oxygen-rich blood flow.

In other words, stroke can be caused by either ischemia, due to lack of blood flow or hemorrhagia, due to bleeding.

A stroke is a medical emergency. Early intervention in most cases can minimize brain damage and potential complications.

According to the statistics, in the US, stroke is the leading cause of serious, long-term disability.
Each year, approximately 795,000 people suffer a stroke and recurrent stroke. Most cases of stroke are associated with adults over the age of 65.

Not all strokes can lead to permanent brain damage. Some people with a temporary disruption of blood flow to the brain do not result in permanent damage.

Besides aging, smoking, medical conditions such as unmanaged high blood pressure and cholesterol and diabetes, obesity, physical inactivity are some of the prevalent factors found in stroke patients.

Some researchers suggested a poor diet pattern such as the Western diet may have a strong impact in elevated the risk of stroke in the Western world.

Dr. Sherzai A, the lead scientist wrote, " Stroke is the fourth leading cause of mortality in the United States, yet it is 80% preventable by addressing lifestyle factors including nutrition".

And, "Adherence to DASH, Mediterranean, and prudent dietary patterns reduced the risk of stroke, whereas the Western dietary pattern was associated with increased stroke risk".

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to find a natural whole food for reducing the risk of stroke researchers examined the effects of ginger in the risk of stroke.

Three candidates from the ginger family identified based on the prediction models in the study were compared to those of the control inhibitor L-454560.

PDE4D inhibitor is a potential drug target used in stroke prevention.

Administration of 3 compounds identified from the ginger family was capable in inhibiting cAMP binding associated with the increase of stroke risk, similar to those of PDE4D.

Genetic polymorphisms of PDE4D (T83C, C87T, and C45T) gene is associated with increased risk of ischemic stroke (IS).

Genetic polymorphisms of ALOX5AP are also associated with ischemic stroke and atherothrombotic events in stroke patients.

In order to reveal more information about ginger anti-stroke risk activity, researchers examined the ginger on the activities of phosphodiesterase 4D (PDE4D) and 5-Lipoxygenase activating protein (ALOX5AP), the two of the major factors involved in the ischemic stroke, accounting for around 80-85% of total stroke.

Injection of ginger not only modulated the expression of PDE4D activities against the activation of cAMP-induced stroke and cardiovascular diseases but also inhibited the overexpression of ALOX5AP that could induce the development of atherosclerosis and stroke through inflammatory pathways.

Take all together, ginger may be considered a functional alternative for the prevention of stroke, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources

(1) In silico pharmacology suggests ginger extracts may reduce stroke risks by Chang TT1, Chen KC, Chang KW, Chen HY, Tsai FJ, Sun MF, Chen CY. (PubMed)
(2) Traditional Chinese medicine, a solution for reducing dual stroke risk factors at once? by Chen KC1, Chang KW, Chen HY, Chen CY. (PubMed)
(3) Stroke, food groups, and dietary patterns: a systematic review by Sherzai A1, Heim LT, Boothby C, Sherzai AD. (PubMed)

The 46 Amazing Health Benefits of Fennel, According to Medical Literature

By Kyle J. Norton

Fennel is a species of Foeniculum Vulgare, belonging to the family Apiaceae (Umbelliferae), native to the shores of the Mediterranean. It is now widely cultivated all around the globe to use as food and herb.

Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc

Chemical constituents
1. 1,3-benzenediol
2. 1-methoxycyclohexene
3. O-cymene
4. Sorbic acid,
5. 2-hydroxy-3-methyl-2-cyclopenten-1-one
6. Estragole
7. Limonene-10-ol
8. 3-methyl-2-cyclopenten-1-one
9. Linoleic acid
10. Oleic acid
11. Undecanal
12. 2,4-undecadienal
13. trans-Anethole
14. Fenchone
15. Limonene
1. Infectious Diseases: The Natural Antibiotics Alternative With No Side Effects
2. Food therapy - Fennel as antioxidants
3. Food Therapy: Fennel In Attenuated Risk, Progression and Treatment of Irritable Bowel Syndrome
4. Food Therapy: Fennel and it's Bioactive Anethole in Attenuated Risk, Progression and Treatment of Periodontitis (PD)
5. Food Therapy: Fennel or Its Composition as Laxative Agent for Treatment of Chronic Constipation
6. Food Therapy: Fennel In Attenuated Risk, Progression and Treatment of Intestinal Dysbiosis
7. Food Therapy: Fennel In Ameliorated Risk, Progression and Treatment of Breast Cancer
8. Herbal Therapy: Fennel, A Potent Functional Food for Treatment of Infantile Colic
9. Herbal Therapy: The Best of Perennially Herbal.Fennel In Ameliorated Risk, Progression and Treatment of Prostate cancer
10. Fennel Seeds, A Potent Galactogenisis in Increased Milk Secretion in Lactation Period
11. Food Therapy; Fennel Seeds, A Potent Galactogenisis in Increased Milk Secretion in Lactation Period
12. Herbal Therapy: Fennel In Reduced Symptoms and Treatment of Estrogenic Deficiency Related Diseases
13. Eat Fennel to Inhibit Daily Stress in the Workplaces, Scientists Suggested
14. Women’s Health: Protect DNA Integrity Against Breast Cancer with This Single Herb, Online Medical Literature Revealed
15. Food Therapy: Intake Fennel to Optimize the Digestive Functioning in absorbed Nutrients and Fluids
16. Food Therapy: Fennel The Potent Food With Cytoprotection and Antitumor Activity
17. Food Therapy: Fennel and Its Extracts in Detoxed Body Toxins, According to PubMed Online Literature
18. Herbal Therapy: Fennel, A Potent Chemo-Preventive and Modulatory Functional Herb
19. Fennel May Improve Your Heart Functioning Naturally and Permanently, Studies Showed
20. How to Treat Painful Primary Dysmenorrhea Quickly and Permanently, According to PubMed
21. 325. Fennel Seed Extracts That Gobble Up Toxins Caused by Drug Interaction and Toxicity, Scientists Show
22. Fennel, The Best Herbal Remedy Which Detoxes Your Kidneys Through Promoting Excess Fluids Secretion, Public Medical Library Reveal
23. Fennel, The Herbal Remedy Which Protects Our Body Against The Onset of Acute Inflammation and Chronic Inflammatory Diseases, Scientists Find
34. Fennel, A Potent Neurons Protective and Memory Enhancing Functional Herb
35. Fennel, The Reliable and Less Expensive Functional Food For Treatment of Hirsutism
36. Detoxification: Fennel, The Potent and Functional Food Which Protects the Liver Against Toxicity
37. Fennel, The Functional Herb Which Processes Anti Anxiolytic Property Similar to Those of Diazepam with No Adverse Effects, Scientists Find
38. Fennel, The Natural Remedy Which Protects the Brain Neurons Against The Onset of Cognitive Impairment, Scientists Suggest
39. Fennel, the Functional Herb Which Processes Anti-antispasmodic Activity, Scientists Find
40. Fennel, the Best Functional Food Which Processes Anti Hypolipidemic Activity
41. Fennel, The Herb Which Causes the Apoptosis of Cancer Cells, Scientists Find
42. Fennel, The Herb Which Causes the Apoptosis of Cancer Cells, Scientists Find
43. Fennel, a Natural Anti Fever Functional Food
44. Fennel, The Natural Free Radical Scavenger, Scientists Find
45. Fennel Essential Oil and Extract, The Potent Anti Hypoglycemic Remedies, Scientists Reveal
46. Fennel, the Function Food Which Balances the Ratio of the Levels Free Radicals and Antioxidants in Our Body

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

The 33 Health Benefits of Carrot, Studies Suggested

By Kyle J. Norton

Carrot, a root vegetable with orange color is a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

Nutrients
1. Carbohydrates
2. Sugars
3. Fibre
4. Fat
5. Protein
6. Vitamin A
7. Thiamine (VittaminB1)
8. Riboflavin (Vittamin B2)
9. Niacin (Vittamin B3)
10. Vitamin B6
11. Folate (Vittamin B9)
12. Vitamin C
13. Vitamin K
14. Calcium
15. Iron
16. Magnesium
17. Molybdenum
18. Phosphorus
19. Potassium
20. Sodium
1. The Science of Root Vegetables: Carrot and its Bioactive Compounds in Prevention and Treatment of Breast cancer
2. Food therapy: Dietary Carrot In Attenuated Onset and Treatment of Prostate Cancer
3. Food Therapy: Carrots In Attenuated Risk, Progression and Treatment of Lung Cancer
4. Food Therapy: Wild Carrot, Single and Hidden Root Vegetable for Treatment of Skin Cancer, Endorsed By Online Published Medical Literature
5. Men’s Health: Protect Prostate Cells Viability Against Prostate Cancer with A Single Vegetable, Medical Literature Recommended
6. Food Therapy: Wild Carrot, Single and Hidden Root Vegetable for Treatment of Skin Cancer, Endorsed By Online Published Medical Literature
7. Food Therapy: Carrot. A Potent and Functional Vegetables in Ameliorated Risk and Treatment of Vulvar Cancer
8. Food Therapy: Carrots Prevent Leukemia
9. The carrot to Maintain A Healthy Skin, Naturally and Permanently, PubMed Studies Find
10. The carrot to Prevent the Onset of Inflammatory Related Diseases Naturally, Medline Model Studies Show

11. Carrots EnhanceYour Immunity Naturally, US National Library of Medicine Studies Suggest
12. Carrots in Decreased Risk of Stroke, Naturally and Effectively, MEDLINE Studies Suggest
13. Carrots' carotenoids, the Secret Ingredients In Protection of Your Heart, Studies Provided by National Institutes of Health
14. Carrot, The Tasty Food That Gobbles Up Pathogenic Microorganisms, Scientists Revealed
15.  The Veggie and Plant That Suppress Oxidative Stress in Induction of Atherosclerosis, Cancers, Diabetes, Rheumatoid Arthritis, Post-ischemic Perfusion Injury, Myocardial Infarction, Cardiovascular Diseases,... and Stroke
16. The Root Vegetable That Prevents Macular Degeneration (AMD), Biomedical Literature Suggest
17. Carrot and Its Bioactive Chemical Compounds in Reduced Risk and Treatment of Colon Cancer
18. Carrot, The Functional Food Which Reduces Gastric/Stomach Cancer Risk By 26%
19. Carrot Stops Colon Cancer Cells From Spreading
20  How to Boost Your Bone Health
21. Carrot, the Potent Liver Protective Functional Food
22. Carrots, The Potent functional Food Which Protects the Brain Against Onset of Neuro-degenerative Disorders, Scientists Reveal
23. Carrots, The Veggie Which Normalizes Your High Blood Pressure With No Side Effects, Suggested By MEDLINE Studies
24. Carrot and its Bioactive Compounds In Reducing Risk, Progression and Treatment of Gastric Cancer
25, How to Protect Your Body From Heavy Metals and Chemical Toxicity, Effectively
26. Carrots, the Veggie Which Normalizes Levels of Blood Glucose in Patient with Hyperglycemia
27. Carrots, the Veggies with Anti Cancer Potential, Researchers Find
28. Carrot, The Vegetable Which Promotes Weight Loss and Prevents the Onset of Obesity
29. How to Have the Optimal Oral Health Naturally
30. Carrots, the Vegetable Which Protects Your Eyes Against Glaucoma, Scientists Find
31. Carrots Juice, The Potential Functional Drink in the Prevention and Treatment of Cardiovascular Disease
32.  Carrot Juice, the Potent Anti Hypertension Functional Food
33. Carrot, the Functional Food Which Normalizes the Levels of Cholesterol, Researchers Suggest

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Herbal Turmeric, the Natural Remedy for the Treatment of Rosacea, Human Study Find

By Kyle J. Norton

Rosacea is a chronic skin condition that affects the face, leading to redness, pimples, swelling, and dilated blood vessels.

The most affected areas are the nose, cheeks, forehead, and chin.

Epidemiologically, the condition may affect anyone, however, middle-aged women who have fair skin are more prone to the disease onset.

Most common symptoms of rosacea are facial redness, swollen red bumps, eye problem, and enlarged nose. If you have to experience the aforementioned symptoms, please check with your doctor to rule out the possibility.

As of today, there is no cure for the condition. Treatments are focused on controlling and reducing the signs and symptoms and improving quality of life, including

* Medications that reduce redness such as drug brimonidine (Mirvaso), particularly in patients with a mild case of rosacea.

* Oral antibiotics for the treatment of bacterial inflammation and infection

* In severe cases, Isotretinoin may be prescribed, if other therapies have failed to improve the condition.

Some researchers suggested that laser therapy may be the best approach to reduce the redness of enlarged blood vessels.

Dr. Daniel M. Keller wrote, "Oxyhemoglobin in the blood absorbs light from lasers at wavelengths of about 595 nm (pulsed dye laser) and 532 nm (KTP laser), creating heat that helps destroy capillaries that contribute to the appearance of rosacea. Over a period of 3-4 weeks, the vessels are resorbed, and facial redness diminishes".

And, "Laser therapy is also effective for background redness but will be less effective for people with the papules associated with rosacea and “almost not effective at all for preventing flushing".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential compound for the treatment of rosacea, researchers examined the effect of turmeric on facial redness, a multifactorial in nature and a sign of many different conditions, including rosacea, photodamage, and flushing.

The prospective, double-blind, randomized pilot study included 33 healthy participants recruited from the dermatology clinic at the University of California, Davis and nearby community from 2016 to 2017.

Participants were randomized to receive one of three interventions (placebo, turmeric or polyherbal combination tablets) by mouth twice daily for 4 weeks.

By comparing the protection of turmeric and turmeric-containing polyherbal combination tablets versus placebo on facial redness, researchers found that facial redness intensity and distribution including rosacea showed a downtrend in the polyherbal combination group after 4 weeks.

Compared to the turmeric-containing polyherbal combination tablets treatment group, the placebo and turmeric groups had no statistically significant changes in image analysis-based facial redness.

In other words, turmeric-containing polyherbal combination tablets processed the ingredients that do not found in turmeric for the treatment of facial redness including rosacea.

Based on the findings researchers said, "Polyherbal combination tablet supplementation improved facial redness compared to the turmeric or placebo".

Taken altogether, turmeric combination with other herbal medicines may be considered supplements for the prevention and treatment of rosacea, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary supplementation with turmeric polyherbal formulation decreases facial redness: a randomized double-blind controlled pilot study by Vaughn AR1, Pourang A2, Clark AK2, Burney W2, Sivamani RK. (PubMed)
(2) Innovations in natural ingredients and their use in skin care by Fowler JF Jr1, Woolery-Lloyd H, Waldorf H, Saini R. (PubMed)
(3) Rosacea responds well to the laser, IPL therapies By Daniel M. Keller. ( MD Edge)

Bromelain, the Natural Promotion of Intestinal Health

By Kyle J. Norton

Intestinal health is a subject that covers multiple positive aspects of the gastrointestinal (GI) tract, including the effective digestion and absorption of food, promoting the balance of intestinal microbiota.

According to general knowledge, people who eat a diet with fruits and vegetables that are high in fiber have been found to process a healthy microbiota including beans and legumes and berries.

Believe it or not, the human gut microbiota contains trillions of cells, including bacteria, viruses, and fungi. The gut microbiota is important to improve the digestive function in the absorption of nutrition, before passing them to the cells and tissue in the body.

In the immunity perspective, the gut microbiota and immune system interact to protect each other to ensure the optimal function of both the digestive and immune system.

In other words, imbalanced gut microbiota not only causes the dysfunction of the digestive system but also reduces the functional immune system in the protection of the body against infection.

Furthermore, in the neuro-perspective, balanced gut microbiota also exerted a strong interaction between the microbiota and the enteric nervous system (ENS), leading to improvement of both systems against the risk of potential diseases that link the microbial dysbiosis to gastrointestinal disorders.

Dr. Sai Manasa Jandhyala, the lead scientist in the summary of the benefits of normal gut microbiota wrote, " The normal gut microbiota imparts specific function in host nutrient metabolism, xenobiotic and drug metabolism, maintenance of structural integrity of the gut mucosal barrier, immunomodulation, and protection against pathogens.

And, Several factors play a role in shaping the normal gut microbiota. They include (1) the mode of delivery (vaginal or cesarean); (2) diet during infancy (breast milk or formula feeds) and adulthood (vegan based or meat based); and (3) use of antibiotics or antibiotic like molecules that are derived from the environment or the gut commensal community. A major concern of antibiotic use is the long-term alteration of the normal healthy gut microbiota and horizontal transfer of resistance genes that could result in a reservoir of organisms with a multidrug-resistant gene pool.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and for the treatment of pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a natural ingredient for the improvement of intestinal health researchers examined the effect of bromelain found in the pineapple on leukocyte migration, activation, and production of cytokines and inflammatory mediators in vitro.

According to the enzyme immunoassays, injection of bromelain induced immune response, However, in the digestive process, bromelain sensitive molecules formulated in antacid from both leukocytes and colon epithelial cells were removed, leading to retaining substantial proteolytic activity.

Where proteolysis is the process of breaking down of proteins into smaller polypeptides or amino acids which play an integral role in removing toxins from the body, supports metabolism, encourage healthy digestion.

Dr. Hale LP, the lead scientist said, "Although anti-bromelain IgG was detected in both serum and stool after long-term oral therapy, these antibodies did not prevent bromelain proteolytic activity within the gastrointestinal tract".

Based on the findings, researchers suggested bromelain enzymes that remain intact after oral administration proteolytically protect the murine gastrointestinal tract by modifying the colonic inflammation.

In order to reveal more information about bromelain used in some developed countries for the protection of colonic inflammation, researchers examined the bromelain, a crude extract from the pineapple stem on digestive health.

In an animal model, oral administration of bromelain improves the decrease in defecation in abdominal postoperative rats.

Furthermore, injection of bromelain inhibited overexpressed the mRNA protein associated with the initiation of inflammation and restored the protein mRNA involved the production of anti-inflammatory cytokines in the colon of the postoperative rats.

Dr. Wen S, the lead scientist said, "(The result strongly suggested that) bromelain improves decrease in defecation in postoperative rats, at least in part, by inhibiting colonic iNOS overexpression via the NF-kappaB pathway".

Taken altogether, bromelain may be considered supplements for the promotion of intestinal health, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources
(1) Proteolytic activity and immunogenicity of oral bromelain within the gastrointestinal tract of mice by Hale LP. (PubMed)
(2) Bromelain improves decrease in defecation in postoperative rats: modulation of colonic gene expression of inducible nitric oxide synthase by Wen S1, Huang TH, Li GQ, Yamahara J, Roufogalis BD, Li Y. (PubMed)
(3) Role of the normal gut microbiota by Sai Manasa Jandhyala, Rupjyoti Talukdar, Chivkula Subramanyam, Harish Vuyyuru, Mitnala Sasikala, and D Nageshwar Reddy. (PMC)

3,3'-Diindolylmethane for the Prevention and Treatment of Renal Fibrosis

By Kyle J. Norton

Renal fibrosis is a condition of kidney scars caused by improper healing of the kidney in regenerating damaged cells after an injury.

The process of kidney healing after injury involved serval overlapping phases, including inflammation, extracellular matrix (ECM) synthesis, production and dissolving collagens, regeneration, and remodeling.

Renal fibrosis over time may result in progressive loss of kidney function, leading to kidney failure in the advanced stage.

Epidemiological studies suggested that age, gender, genetics, and perpetual activation of fibroblasts through priming are some of the prevalent factors that cause on the set of poor healing of kidney in the initiation of renal fibrosis.

Most patients with renal fibrosis are asymptomatic. Therefore, most cases of renal fibrosis are diagnosed at the advanced stage.

At this stage, patients may experience symptoms of chronic kidney disease (CKD), including weight loss and poor appetite. swollen ankles, feet or hands due to water retention, and blood in your urine.

As of today, there are no effective treatments for preventing the progression of renal fibrosis. Treatments of renal fibrosis are to reduce symptoms and delay the disease progression of the disease.

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

On finding a natural compound for the treatment of renal fibrosis with no side effects, researchers in the renal disease team led by the Renmin Hospital of Wuhan University examined 3,3'-Diindolylmethane (DIM), a natural acid condensation extracted from cruciferous plants, anti-fibrotic effects.

Selected rat kidney (NRK)-49F fibroblast cell mouse models induced renal fibrosis by a unilateral ureteral obstruction (UUO) and stimulated the production of transforming growth factor (TGF)-β1.

Where transforming growth factor (TGF)-β1 are inflammatory cytokines that frequently occur together during a regulatory T cell response.

According to the tested assays, treatment of DIM reduced kidney injury and production of interstitial collagens fibrosis.

Furthermore, DIM inhibited the expression of fibronectin involved in cell adhesion, growth, migration, and differentiation and increased fibronectin were found to associate with hypertrophic scars. and collagen-1 the collagen fiber involved the formation of scars.

Moreover, DIM promotes the expression of a protein associated with tumor suppression E-cadherin in the UUO model that protects the healing against the formation of scars.

DIM suppressed local fibroblast proliferation, a process that begins with a reaction to the clot associated with scar developing, observed by the scar contraction with the level of α-smooth muscle actin (α-SMA) and vimentin in scar tissue.

Additionally, DIM inhibited the renal fibrosis by significantly reduced the TGF-β1-induced proliferation of NRK49F cells in a time- and dose-dependent manner.

Interestingly, DIM decreased Smad2/3 phosphorylation associated with the excessive deposition of collagen and but increased Smad7 expression against keloid formation.

The results strongly suggested DIM inhibited the transforming growth factor (TGF)-β1 in the activation of proteins and genes associated with the formation of scarrings.

Dr. Xia ZE, the lead scientist said, " DIM inhibits TGF-β/Smad2/3 signaling to attenuate renal interstitial fibrosis via inhibiting local fibroblast activation".

Taken altogether, DIM may be considered a supplement for the prevention and treatment of renal fibrosis through its anti- renal scarring activity, pending to the confirmation fo larger sample size and multicenter human study.

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of renal fibrosis,, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3,3'-Diindolylmethane ameliorates renal fibrosis through the inhibition of renalfibroblast activation in vivo and in vitro by Xia ZE1, Xi JL2, Shi L. (PubMed)