Coffee in Reduced Overall Risk of Cancers, Studies Found

Kyle J. Norton

The California judge ruled  that some coffee sellers were required to brand the beverage with cancer warning labels due to containing acrylamide, a chemical compound in the a list of chemicals in facilitated cause of cancer or reproductive harm.

According to the national cancer institute, acrylamide to be reasonably anticipated to be a human carcinogen, based on studies in laboratory animals given acrylamide in drinking water.

Acrylamide, a chemical substance used primarily to make polyacrylamide and acrylamide copolymers. has been included in that list since 1990.

Acrylamide (AA) is classified as a Group 2A carcinogen according to the International Agency for Research on Cancer, but  coffee only contains a small amount of AA.

However, according to Dr. Wierzejska R,  " The former (coffee) include polyphenols which inhibit harmful oxidation processes in the body, while the latter (coffee) include acrylamide, whose high intake in daily diet may have carcinogenic action" and "According to the current state of knowledge, coffee consumption is not associated with the majority of cancers although the results of studies on bladder and lung cancer remain conflicting" and "In case of colorectal, liver and breast cancers, coffee drinking may even have a protective effect" and "Coffee contains numerous compounds, potentially beneficial as well as harmful.

Contentiously, the author suggested that the impact of coffee on the human body is associated also with other factors, e.g. the rate of metabolism and other individual features.

Further more, according to the reviewed available evidence on coffee drinking and the risk of all cancers and selected cancers updated to May 2016 by the University of Milan with pooled relative risk (RR) for an increment of 1 cup of coffee/day of 1.00 [95% confidence interval (CI): 0.99-1.01] for all cancers
*. Coffee drinking is associated with a reduced risk of liver cancer and an increment of consumption of 1 cup/day is also associated to reduced risk of 0.85 (95% CI: 0.81-0.90) for liver cancer and a favorable effect on liver enzymes and cirrhosis.

*. Another meta-analysis showed an inverse relation for endometrial cancer risk, with an RR of 0.92 (95% CI: 0.88-0.96) for an increment of 1 cup/day.

* A possible decreased risk was found in some studies for oral/pharyngeal cancer and for advanced prostate cancer.

* Although data are mixed, overall, there seems to be some favorable effect of coffee drinking on colorectal cancer in case-control studies, in the absence of a consistent relation in cohort studies.

* For bladder cancer, the results are not consistent; however, any possible direct association is not dose and duration related, and might depend on a residual confounding effect of smoking.

* A few studies suggest an increased risk of childhood leukemia after maternal coffee drinking during pregnancy, but data are limited and inconsistent.

* Although the results of studies are mixed, the overall evidence suggests no association of coffee intake with cancers of the stomach, pancreas, lung, breast, ovary, and prostate overall. 

* Data are limited, with RR close to unity for other neoplasms, including those of the esophagus, small intestine, gallbladder and biliary tract, skin, kidney, brain, thyroid, as well as for soft tissue sarcoma and lymphohematopoietic cancer.

Moreover, the above analysis also were supported by the University of California in the examine the epidemiologic evidence, consisting of over 500 papers relating the consumption of coffee to cancer of various sites, has accumulated up to date.

Researchers at the end of the investigation suggested that
* For hepatocellular and endometrial cancers, there appears to be a strong and consistent protective association; for colorectal cancer, the direction of association is borderline protective.
*There appears to be no association with breast, pancreatic, kidney, ovarian, prostate, or gastric cancer.
* Risk of bladder cancer appears to be associated with heavy coffee consumption in some populations and among men.
*The associations with childhood leukemia and mother's consumption of coffee were ambiguous-with some suggestion of risk at high levels of daily consumption.

Finally, in the search of MEDLINE, EMBASE, Science Citation Index Expanded and bibliographies of retrieved articles including prospective cohort studies in reported relative risks (RRs) and corresponding 95% confidence intervals (CIs) of various cancers with respect to frequency of coffee intake, scientists found that 

* In compared to individuals who did not or seldom drink coffee per day, the pooled RR of cancer was 0.87 (95% CI, 0.82-0.92) for regular coffee drinkers, 0.89 (0.84-0.93) for low to moderate coffee drinkers, and 0.82 (0.74-0.89) for high drinkers based on results of 59 studies, consisting of 40 independent cohorts, met the inclusion criteria.

* Overall, an increase in consumption of 1 cup of coffee per day was associated with a 3% reduced risk of cancers (RR, 0.97; 95% CI, 0.96-0.98).

* In subgroup analyses, coffee drinking was associated with a reduced risk of bladder, breast, buccal and pharyngeal, colorectal, endometrial, esophageal, hepatocellular, leukemic, pancreatic, and prostate cancers.

Taken together, the judge is right in the following logic, Acrylamide induces risk of cancers, coffee contains Acrylamide, coffee induces risk of cancers, without taking into account of other factors.

However, if you look into the big and broader pictures and take into account of other major active phytochemicals, coffee processes tons of health benefits, including reducing overall risks of cancer.

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Sources
(1) Coffee and cancer risk: a summary overview by Alicandro G1, Tavani A, La Vecchia C.(PubMed)
(2) Coffee consumption and risk of cancers: a meta-analysis of cohort studies by Yu X1, Bao Z, Zou J, Dong J.(PubMed)
(3) Coffee consumption vs. cancer risk - a review of scientific data by Wierzejska R1.(PubMed)
(4) Epidemiologic evidence on coffee and cancer.by Arab L1.

Herbal Therapy: Arnica, A Potent Function Herb in Reduced Risk, Progression and Treatment of Inflammatory Arthritis

Arnica may have substantial and therapeutic values in reduced risk, progression and treatment of inflammatory arthritis, some scientists suggested.

The results of these efficacy were reported by numbers of respectable institutes and published on online medical literature, including  the University of Medicine and Pharmacy and University of Mauritius.

Arthritis is a chronic condition characterized by inflammation of more than one joint.

According to the statistic, rheumatoid arthritis, one of common type of arthritis, is a chronic disease affecting over 1.3 million Americans and at least 1% of the worldwide population.

Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, antive to Europe and Asia, used in herbal medicine for centuries to treat strains, sprains, and bruises.
Wound healing is process of repairing after damage of skin, tissues, organs, etc.


The ingredients
Helenalin, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivative.

In the finding of a natural source of alternative agent in replaced the conventional medication (ranging from pain-killers to biological agents) is potent, but frequently associated with serious, even life-threatening side effects, researchers at the joint study conducted by the University of Medicine and Pharmacy, found that Arnica montana is found effective in at least in studies done in vitro or on animal models.

Other researchers also in the searching of the same by looking into the major scientific databases; Google Scholar, Pubmed, ScienceDirect, and Scopus were explored to highlight novel therapeutic approaches using herbal products for CAIDs prophylaxis, management, treatment, and prevention of relapse found that herbal products, including Arnica can act on multiple targets involved in the pathogenesis.

In compared to other herbal and antioxidants used in the experienment, Arnica demonstrated a significant activity in improved pain and physical function in patients suffering from osteoarthritis 

Further analysis suggested that Arnica alleviated pain in patients with osteoarthritis was associated to reduce over immune over response in production of pro inflammatory factors to the site of infection in facilitated damage and cell of the joint through its anti inflammatory effects.

Some researchers postulated that Arnica may also reduce joint inflammation through the expression of the plant antioxidants and stimulation of the antioxidants in the host tissue, thus decreasing the risk of imbalance of the ratio of reactive oxygen species and antioxidant in precipitation of the symptoms and progression of osteoarthritis.

Dr. Mahomoodally F, the lead author after taking into account of other co and con founders, said, " In silico approaches remain also a pertinent avenue to unveil highly compatible herbal metabolites binding multiple targets involved in inflammation".

More importantly, in the animal modles to investigate the therapeutic effects and mechanism of action of A. montana flower methanol extract (AMME) against both inflammation and oxidative stress in a collagen-induced arthritis (CIA), scienntists showed that application of montana flower methanol extract (AMME) exerted significant activities against both inflammation and oxidative stress in a collagen-induced arthritis (CIA).

Additional differentiation found that oral administration of AMME was found to reduce clinical signs and improve the histological and radiological status of the hind limb joints by ameliorated the expression levels of nitric oxide, tumor necrosis factor-α, interleukins (IL-1β, IL-6 and IL-12) and titer of anti-type II collagen antibody compared with untreated CIA rats. 

Nitric oxide (NO) is an enzyme involved in the induction of inducible type-2 isoform of nitric oxide synthase (NOS-2), in activated toxic defense molecule against infectious organisms, however, over production of NO may cause cells damage and apoptosis at the site of infection.

Tumor necrosis factor-α, interleukins (IL-1β, IL-6 and IL-12) are all proinflammatroy cytokines produced by immune system to protect cell in the infection against invasion of micro organisms. Over expression was also associated to risk of cell damage and apoptosis.

High levels of type II collagen antibody is one of biomarkers associated with concurrent but not later signs of inflammation.

Dr. Sharma S, at the end of the experiment said, " by inhibiting these mediators, AMME also contributed towards the reversal of disturbed antioxidant levels and peroxidative damage".

Taken together, Arnica and its bio extracts may be considered as a functional food in reduced risk, progression and treatment of inflammatory arthritis without inducing intolerant adverse effects

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Cumulative therapeutic effects of phytochemicals in Arnica montana flower extract alleviated collagen-induced arthritis: inhibition of both pro-inflammatory mediators and oxidative stress by Sharma S1, Arif M1, Nirala RK1, Gupta R2, Thakur SC1.(PubMed)
(2) Phytomedicine in Joint Disorders by Dragos D1,2, Gilca M3, Gaman L4, Vlad A5, Iosif L6, Stoian I7,8, Lupescu O(PubMed)
(3) Herbal products for common auto-inflammatory disorders - Novel approaches by Mahomoodally F1, Suroowan S1(PubMed)

Researchers Recommended: Intake of These Fruits in Inhibition of Prostate Cancer

Kyle J. Norton

The widespread of prostate cancer, once considered a disease of aging male, now has become major concerns of governments and scientific community in South East Asian with tendency toaffect even younger age population.

Evidences emerged of over consuming bad fats in any time in the history accompanied with unhealthy  life style may be the possible causes of the disease, linking to the economic prosperity over 2 decades.

Prostate cancer is a medical condition characterized by irregular cell growth in the prostate tissue. At the later state, the cancerous cells may travel a distance away from the original site to infect other healthy tissue or organ.

Most prostate cancers are slow growing. Enlarged prostate and prostate cancer may be detected during physical (rectum) exams.

The Fruits for reducing risk of Prostate cancer
1. Mangosteen fruit
Mangosteen fruit, a tropical fruit growth in South East Asia is an evergreen tree originated in the Sunda Islands and the Moluccas of Indonesia.

In 22Rv1, LNCaP, and prostate epithelial cells (PrECs), standardized mangosteen fruit extract (MFE), suppressed tumor growth in a xenograft tumor model without causing damage to non-tumorigenic prostate epithelial cell through induction of toxicity(46).

Polyphenols, the main chemical constituent of the fruit extract also targeted multiple signaling pathways involved cell cycle arrest and apoptosis in prostate cancer(47).
rate
 α-Mangostin, a xanthone derived from Polyphenols of mangosteen fruit, demonstrated a significant effect in exhibited cell cycle-related proteins involved in prostate carcinogenesis(48).

2. Long Pepper or Indian long pepper
Used as a spice and seasoning, Long Pepper or Indian long pepper is a flowering vine in the family Piperaceae.

Piperlongumine (PL), a natural alkaloid presented in the fruit inhibited prostate cancer through downregulation of Akt downstream signaling of  cell proliferation, resulting in decrease mTORC1 (nutrient/energy)activity and autophagy (cell degradation)stimulation(49).

Application of PL also induced rapid depletion of the Androgen receptor (AR) in prostate cancer (PC) cells which is an early indication of prostate cancer(50).

 In human prostate cancer DU145, PC-3 and LNCaP cells, piperine, another an alkaloid from black and longpeppers, also exhibited anti-proliferative effect in human prostate cancer cells by inducing cell cycle arrest and autophagy(51).

3. Pomegranate
Pomegranates is a fruit-bearing small tree, genus Punica, belongings to family Lythraceae, native to Iran, cultivated in Asian since ancient time.

POMx, a omegranate (PE) formula currently approved for clinical trials, effectively inhibited survivin (baculoviral inhibitor), induced apoptosis, retarded the rate of tumor growth in skeleton(52).

Polyphenols, main chemical compounds from pomegranate fruit extracts (PFEs), slightly decreased secretion of matrix metalloproteinase (MMP)-2 but not MMP-9 (expression usually seen in invasive and highly tumorigenic cancers) from prostate cancer cell lines(53).

Other polyphenol derivative, ellagic acid (EA) converted from Ellagitannins (ETs) from pomegranate juice (PJ), significantly decreased cell proliferation by exhibiting synergism in PC-3 cells(54).

4. Strawberry
Strawberries is a genius of Fragaria × ananassa belongings to the family Roseaceae, grown all over the world with suitable climate for commercial profits and for health benefits.

Application of berry juice study, including strawberry, inhibited prostate cancer cell proliferation, not involve caspase-dependent apoptosis, but in cell-cycle arrest, by down-regulation of the expression of cdk4, cdk6, cyclin D1 and cyclin D3(Decrease the proliferative activity (55).

 In fact,  major classes of berry phenolics, including anthocyanins, flavonols, flavanols, ellagitannins, gallotannins, proanthocyanidins, and phenolic acids are found to be effective in attenuated growth of many human cancer cell lines, including prostate (LNCaP) tumor cell lines at concentrations ranging from 25 to 200 micro g/mL.(56).

 Crude extracts (250 microg/mL) from strawberry and its pure compounds (100 microg/mL) also  induced apoptosis of prostate (LNCaP, DU145) cancer cells(57).

5. Grapes
Grape is a woody vines of the genus Vitis, belongings to the family Vitaceae, native to southern Turkey.

Fisetin, a chemical compound found in grape inhibited prostate cancer cell lines through downregulation of the PI3K/Akt (anti-apoptosis and increased cell proliferation)and the mTOR(energy sources) pathways(58).

Another chemical constituent pterostilbene, in dose-dependent ameliorated cellular proliferation, through activation of expression of AMPK(cellular energy homeostasis) and the p53(antigens).

But in p53 positive LNCaP cells, pterostilbene blocked the progression of cell cycle at G1 phase by inducing p53 expression and further up-regulating p21 expression and in p53 negative, induced apoptosis in PC3 cells(59).

Piceatannol found in grape, exhibited potential anticancer properties by suppressing proliferation of a wide variety of tumor cells, through cell-cycle arrest, upregulation of antibody antigens and apoptotic activity and down-regulation of cancer cell proliferation(60).

6. Apple
Apple is the pomaceous fruit of the apple tree, a species of the rose family Rosaceae,  cultivated tree fruits. The tree is originated in Central Asia.

Apple peel extract (APE), exerted its anti cancer effects by significant decrease growth and enhanced clonogenic survival of human prostate carcinoma CWR22Rnu1 and DU145 cells, through a G0-G1(Cell cycle) phase arrest(61).

In the study of Does an apple a day keep the oncologist away? showed an inverse association of apple intake and incidence of cancer(62).

7. Papaya
Papaya is a species of Carica Papaya, belongings to the family Caricaceae and native to the tropics of the Americas, first cultivated in Mexico and several centuries.

Benzylisothiocyanate (BITC), a solvent of papaya fruit inhibited cancer cell line through induced apoptosis by converging two major pathways: the death receptor mediated extrinsic and the mitochondrial intrinsic pathway(63).

In the role of diet, papaya is effectively (more than 22.7 g/d (50th percentile) reduced prostate cancer risk by 7.4 (Adjusted OR 7.4 (95% CI 1.17-46.8)(64).

Lycopene, a major chemical constituent in tomato, also in papaya, in prospective and retrospective epidemiological studies showed an inverse relationship between lycopene intake and prostate cancer risk in vitro and in vivo(65).

8. Apricot
Apricot tree is about 8–12 m tall and a trunk up to 40 cm diameter belongings to the family Rosaceae.

Ethanolic extracts (30%) of apricot inhibited  the growth of PC-3 and LNCaP (Prostate cancer cell lines) cells through induction of apoptosis via down regulating ERalpha (estrogen receptor α), ) and PKC-alpha(interaction with the cell membrane) protein, and binding of  both mouse uterine estrogen receptors and LNCaP human androgen receptors(66).

9. Avocado
Avocado, a commercially valuable fruit cultivated in tropical climates throughout the world is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America.

Whole-blood fatty acids testing indicated that higher intakes of dietary MUFA(monounsaturated fatty) with principal source of dietary avocadointake was inversely related to prostate cancer(67).

Acetone extract of avocado, containing carotenoids and tocopherols decreased growth of both androgen-dependent (LNCaP) and androgen-independent (PC-3) prostate cancer cell lines in vitro.

Incubation of PC-3 cells with the avocado extract led to G(2)/M cell cycle arrest accompanied by an increase in p27(cell cycle inhibitor) protein expression(68).

10. Citrus fruits
The fruit is the genus Citrus, native to southern and southeast Asia, include grapefruit, lemon, orange, etc.

Study of incidence of prostate caner in North India compared to South India, showed a positive decreased risk of prostate cancer  in increasing dietary consumption of tea, citrus fruits and melon(69).

Citrus consumption is associated with reduced all-cancer incidences, according to the study of cancer incidence among 42,470 Japanese adults in the Ohsaki National Health Insurance Cohort(70).

Oral administration of Gold Lotion (GL), an extract of multiple varieties of citrus peels containing abundant flavonoid, showed the deduction of both the weights (57%-100% inhibition) and volumes (78%-94% inhibition) of the tumors without inducing any adverse toxicity, accompanied by mechanistic down-regulation of the protein levels of inflammatory enzymes (inducible nitric oxide synthase, iNOS and cyclooxygenase-2, COX-2), metastasis (matrix metallopeptidase-2, MMP-2 and MMP-9), angiogenesis (vascular endothelial growth factor, VEGF), and proliferative molecules, as well as inducing apoptosis in prostate tumors(71).

Unfortunately, some studies did not show an association between intake of citrus fruits and risk of prostate cancer(72).

11. Bitter melon
Bitter melon, a extremely bitter fruit, is a tropical and subtropical vine belongings to the family Cucurbitaceae, native in Asia, Africa, and the Caribbean.

Treatment of bitter melon extract (BME) in prostate cancer, enhanced Bax expression(involved in p53-mediated apoptosis) and induced PARP(a nuclear protein implicated in DNA repair) cleavage(during apoptosis), delayed the progression to high-grade prostatic intraepithelial neoplasia (precede the development of prostate adenocarcinoma) and displayed approximately 51% reduction of proliferating cell nuclear antigen expression in mice(73).

MCP30, from bitter melon seeds induced apoptosis in PIN and PCa cell lines in vitro and suppressed PC-3 growth in vivo with no effect on normal prostate cells(74).

Bitter melon leaf extract (BMLE) inhibited the secretion of MMP-2, MMP-9(metastasis) and urokinase plasminogen activator (uPA)(invasion and metastasis) from rat prostate cancer cell line (PLS10)(75).

Taken together, the information findings suggested that certain fruits and theirs bioactive compound may have a strong impact in reduced risk, progression and treatment. however, due to limitation of the sample, a large cohost study with larger sample size are necessary to reconfirm their viability.



Natural Medicine for Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrion, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
References
(46) Selective modulation of endoplasmic reticulum stress markers in prostate cancer cells by a standardized mangosteen fruit extract by Li G1, Petiwala SM1, Pierce DR1, Nonn L2, Johnson J(PubMed)
(47) Polyphenols from the mangosteen (Garcinia mangostana) fruit for breast and prostate cancer by Li G, Thomas S, Johnson JJ.(PubMed)
(48) α-Mangostin, a xanthone from mangosteen fruit, promotes cell cycle arrest in prostate cancer and decreases xenograft tumor growth by Johnson JJ, Petiwala SM, Syed DN, Rasmussen JT, Adhami VM, Siddiqui IA, Kohl AM, Mukhtar H.(PubMed)
(49) Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death by Makhov P, Golovine K, Teper E, Kutikov A, Mehrazin R, Corcoran A, Tulin A, Uzzo RG, Kolenko VM.(PubMed)
(50) Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells by Golovine KV, Makhov PB, Teper E, Kutikov A, Canter D, Uzzo RG, Kolenko VM.(PubMed)
(51) Piperine inhibits the proliferation of human prostate cancer cells via induction of cell cycle arrest and autophagy by Ouyang DY, Zeng LH, Pan H, Xu LH, Wang Y, Liu KP, He XH.(PubMed)
(52) Pomegranate extract inhibits the bone metastatic growth of human prostate cancer cells and enhances the in vivo efficacy of docetaxel chemotherapy by Wang Y, Zhang S, Iqbal S, Chen Z, Wang X, Wang YA, Liu D, Bai K, Ritenour C, Kucuk O, Wu D.(PubMed)
(53) Ellagic acid inhibits migration and invasion by prostate cancer cell lines by Pitchakarn P, Chewonarin T, Ogawa K, Suzuki S, Asamoto M, Takahashi S, Shirai T, Limtrakul P.(PubMed)
(54) Pomegranate Juice Metabolites, Ellagic Acid and Urolithin A, Synergistically Inhibit Androgen-Independent Prostate Cancer Cell Growth via Distinct Effects on Cell Cycle Control and Apoptosis by Vicinanza R, Zhang Y, Henning SM, Heber D.(PubMed)
(55) Inhibition of cancer cell proliferation and suppression of TNF-induced activation of NFkappaB by edible berry juice by in D, Blanchette M, Barrette S, Moghrabi A, Béliveau R.(PubMed)
(56)Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro by Seeram NP, Adams LS, Zhang Y, Lee R, Sand D, Scheuller HS, Heber D.(PubMed)
(57)Isolation and identification of strawberry phenolics with antioxidant and human cancer cell antiproliferative properties by Zhang Y, Seeram NP, Lee R, Feng L, Heber D.(PubMed)
(58) Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management by Adhami VM, Syed DN, Khan N, Mukhtar H.(PubMed)
(59) Activation of AMPK by pterostilbene suppresses lipogenesis and cell-cycle progression in p53 positive and negative human prostate cancercells by Lin VC, Tsai YC, Lin JN, Fan LL, Pan MH, Ho CT, Wu JY, Way TD.(PubMed)
(60) Biological activity of piceatannol: leaving the shadow of resveratrol by Piotrowska H, Kucinska M, Murias M.(PubMed)
(61) Antiproliferative effects of apple peel extract against cancer cells by Reagan-Shaw S, Eggert D, Mukhtar H, Ahmad N.(PubMed)
(62) Does an apple a day keep the oncologist away by Gallus S, Talamini R, Giacosa A, Montella M, Ramazzotti V, Franceschi S, Negri E, La Vecchia C.(PubMed)
(63) Dietary isothiocyanate mediated apoptosis of human cancer cells is associated with Bcl-xL phosphorylation by Basu A, Haldar S.(PubMed)
(64) Roles of diet, lifetime physical activity and oxidative DNA damage in the occurrence of prostate cancer among men in Klang Valley, Malaysia by Shahar S, Shafurah S, Hasan Shaari NS, Rajikan R, Rajab NF, Golkhalkhali B, Zainuddin ZM.(PubMed)
(65) Multitargeted therapy of cancer by lycopene by van Breemen RB, Pajkovic N.(PubMed)
(66) Phytosterol Pygeum africanum regulates prostate cancer in vitro and in vivo by Shenouda NS, Sakla MS, Newton LG, Besch-Williford C, Greenberg NM, MacDonald RS, Lubahn DB.(PubMed)
(67)Associations of whole-blood fatty acids and dietary intakes with prostate cancer in Jamaica by Jackson MD, Walker SP, Simpson-Smith CM, Lindsay CM, Smith G, McFarlane-Anderson N, Bennett FI, Coard KC, Aiken WD, Tulloch T, Paul TJ, Wan RL.(PubMed)
(68)Inhibition of prostate cancer cell growth by an avocado extract: role of lipid-soluble bioactive substances by Lu QY, Arteaga JR, Zhang Q, Huerta S, Go VL, Heber D(PubMed)
(69) A case control study on prostate cancer in Delhi by Tyagi B, Manoharan N, Raina V.(PubMed)
(70) Citrus consumption and cancer incidence: the Ohsaki cohort study by Li WQ, Kuriyama S, Li Q, Nagai M, Hozawa A, Nishino Y, Tsuji I.(PubMed)
(71) Potent anti-cancer effects of citrus peel flavonoids in human prostatexenograft tumors by Lai CS, Li S, Miyauchi Y, Suzawa M, Ho CT, Pan MH.(PubMed)
(72) Citrus fruits intake and prostate cancer risk: a quantitative systematic review by Bae JM, Lee EJ, Guyatt G.(PubMed)
(73) Bitter melon extract impairs prostate cancer cell-cycle progression and delays prostatic intraepithelial neoplasia in TRAMP model by Ru P, Steele R, Nerurkar PV, Phillips N, Ray RB.(PubMed)
(74) Ribosome-inactivating proteins isolated from dietary bitter melon induce apoptosis and inhibit histone deacetylase-1 selectively in premalignant and malignant prostate cancer cells by Xiong SD, Yu K, Liu XH, Yin LH, Kirschenbaum A, Yao S, Narla G, DiFeo A, Wu JB, Yuan Y, Ho SM, Lam YW, Levine AC.(PubMed)
(75) Momordica charantia leaf extract suppresses rat prostate cancerprogression in vitro and in vivo by Pitchakarn P, Ogawa K, Suzuki S, Takahashi S, Asamoto M, Chewonarin T, Limtrakul P, Shirai T.(PubMed)

Scientists Suggested: Intake of These 8 Vegetables in Prevention and Treatment of Benign Prostatic Hyperplasia(BPH)

Kyle J. Norton

Benign prostatic hyperplasia(BPH) is a condition, characterized by increased in the number of cells of prostate gland, causing partial, or sometimes virtually complete obstruction of the urinary tract.

According to statistic, BPH commonly starts at age of 30 and symptoms usually can not be realized until age of 50. More than half of men between age of 60-70 are experience symptoms of BPH and only 10% are required treatment.

Suggestion of BPH is associated to nutritional status and eating habits,.

According to the study, 30 male patients with clinically confirmed and treated disease of the prostatic gland, including 15 men (aged 51-75 years) with BPH and 15 men (aged 51-73 years) with PC, improper nutritional status lead to incorrect nutritional habits which fail to improve health status may be the cause of the development of some diet-dependent diseases, such as BPH and prostate cancer(a).

A proper diet with vegetable, fruit containing zinc may reduce the risk of the disease from starting(b)(c).


Epidemiological studies, indicated that intake of vegetables and fruits accompanied with healthy life style may be associated in prevented risk and treatment of enlarged prostate(d)(e)(f).

The efficacy may be due to enhancement of antioxidants effect on over production of prostate cells(g)(h).

Types of vegetables in reduced risk of BPH
1. Tomato
Tomato is a red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, tomato is grown world wide for commercial purpose and often in green house.

According to the study by Institute of Biological Chemistry and Nutrition, lycopene found in tomato inhibited the progression and reduced symptoms of BPH.(1)

 But, intake of lycopene in the study at Universität Bonn, showed no protection from the development of PCA(5), but consumption of tomato products, lycopene ingestion might also be effective in PCA therapy(2).

Profluss®), composition of Serenoa repens, selenium and lycopene, displayed a siginificant antiinflammatry activities in reduced risk of BPH by reducing extension and grading of flogosis(3) and relieve the BHP symptoms(4).


2. Onion
The onion is a plants in the genus Allium, belongings to the family Alliaceae, a close relation of garlic.

the evggy is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

Suggestion of rich sources of flavonoids may be effective in treating benign prostatic hyperplasia (BPH)(6).

According to the Istituto di Ricerche Farmacologiche Mario Negri, intake of onion showed an inverse association of BPH(7).

3. Whole grain
Wholegrain is cereal grains containing cereal germ, endosperm, and bran.

The study by Beijing Medical University, conducted in 1993-1995 in Beijing of BPH in 413 rural and 419 urban male over 40 years of age, showed an increased BPH incidence with daily intake of total calories, fat and animal protein, and the decreased daily intake of vegetables and whole grain, the sources of phytoestrogens(8).

The study of the University of Illinois in Chicago, indicated an inverse associations with dietary intake of plant foods, including whole grain cereals(9).

Other researchers suggested that BPH is associated with elevations in plasma estradiol/testosterone ratio, insulin, and insulin-like growth factor-I and daily aerobic exercise can reduce all of these plasma factors, particularly when combined with a low-fat, high-fiber diet consisting of whole grains, fruits, and vegetables(10).

4. Organic soybean
Soybean is genus Glycine, the family Fabaceae.

One of the legumes that contains twice as much protein per acre as any other major vegetable or grain crop, native to Southeast Asia.

Now, it is grown worldwide with suitable climate for commercial profit and a healthy foods.

In a rat model of benign prostatic hyperplasia (BPH), Application of Anthocyanin, a major chemical constituent in the pigment and potent antioxidant of black soy bean, showed to inhibit the volume and suppress the proliferation of the prostate(11) and

The study Central South University, also indicated that soybean isoflavone inhibits prostate hyperplasia through increased expressions of nitric oxide and nitric oxide synthase in rats(12).

Moreover, the soybean Isoflavone also found to reduced the risk of prostate hyperplasia through increased acid phosphatase and PAP in a dose-dependent manner in rats, according to the Central South University, in Shanghai(13).

5. Cruciferous vegetables
Cruciferous vegetables are the group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli etc.

Sulforaphane (SFN) an isothiocyanate derived from cruciferous vegetables in the study of its effect in normal (PrEC), benign hyperplasia (BPH1) and cancerous (LnCap and PC3) prostate epithelial cells  induced cell cycle arrest and apoptosis in BPH1, through its activities in effects on cell proliferation, HDAC activity and downstream targets in normal and cancer cells(14).

Ethyl isothiocyanate (PEITC), found in cruciferous vegetables, in the testing on androgen-influenced growth of the prostatesuch as benign hyperplasia, showed to regulate the hormone-dependent growth of the prostate, through negated the testosterone-mediated enhancement of the androgen receptor (AR), via down-regulating transcription factor Sp1 expression and Sp1 binding complex formation(15).

6. Squash
Squash is the genus Cucurbita, belongings to family Cucurbitaceae and native to Mexico and Central America.

In North America, squash is divided into summer squash or winter squash, depending on the maturity of squash when harvested, immature fruit called summer squash and mature fruit called winter squash.

ProstateEZE Max, a herbal formula containing Cucurbita pepo, Epilobium parviflorum, lycopene, Pygeum africanum and Serenoa repens in the study of benign prostate hypertrophy (BPH) demonstrated a  positive effect in improvement of physical symptoms of BPH after 3 months of intake(16).

However, the Minneapolis VA Center for Chronic Diseases Outcomes Research in the reviews of 6 phytotherapeutic agents (Serenoa repens, Hypoxis rooperi, Secale cereale, Pygeum africanum, Urtica dioica, Curcubita pepo)from 44 studies, showed no convincing evidence supporting the use of Curcubita pepo alone for treatment of BPH(17).

7. Spinach
Spinach is an edible flowering plant in the genus Spinacia, belongings to the family of Amaranthaceae and native to central and southwestern Asia.

The green leaves vegetable is considered as a healthy plant containing vary vitamins and minerals.

The study of the effect of 3 anti-oxidants [a water-soluble natural anti-oxidant. NAO (200 mg/kg). found in spinach leaves; epigallocatechin-3 gallate, EGCG (200 mg/kg), a major green tea polyphenol; and N-acetylcysteine, NAC (125 mg/kg)]  in TRAMP and wild-type male mice also indicated an improved  NAO in reduced hyperplasia at weeks 9 and 13(18).


In a case-control study of prostatic cancer which consisted of 100 patients with prostatic cancer, matched for hospital, age (+/- 3 yr) and hospital admission date (+/- 3 months) to patients with benign prostatic hyperplasia(BPH) and hospital controls, conducted by the Kyoto University, researcher found that frequent intake of spinach (RR = 1.96: 1.01-7.73), a typical green and yellow vegetable, was associated to reduced risk BPH and prostate cancer(19).

8. Mushrooms
Mushroom, a standard name of white button mushroom is the fleshy, spore-bearing fruiting body of a fungus produced above ground on soil or on its food source, belonogongs to the genus A. Muscaria in the family Amanitaceae.

In the examination of methanol extracts of 19 edible and medicinal mushrooms on 5alpha-reductase activity indicated an inhibited effects of the testosterone-induced growth of the ventral prostate in castrated rats(20).

But the study conducted by Gunma University Graduate School of Medicine, Maebashi suggested oral administration of extract of mushroom Phellinus linteus induced prostate enlargement(21).

Therefore using mushroom in treating BPH should be taken with care only with the approval of specialist.



For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Natural Medicine for Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve Optimal Health And Loose Weight

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Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

References
(a) Nutritional status and nutritional habits of men with benign prostatic hyperplasia or prostate cancer - preliminary investigation by Goluch-Koniuszy Z, Rygielska M, Nowacka I.(PubMed)
(b) Diet and benign prostatic hyperplasia: a study in Greece by Lagiou P1, Wuu J, Trichopoulou A, Hsieh CC, Adami HO, Trichopoulos D.(PubMed)
(c) Associations of obesity, physical activity and diet with benign prostatic hyperplasia and lower urinary tract symptoms by Raheem OA1, Parsons JK.(PubMed)
(d) Nutrition and benign prostatic hyperplasia by Espinosa G.(PubMed)
(e) Dietary patterns and prostatic diseases by Sebastiano C1, Vincenzo F, Tommaso C, Giuseppe S, Marco R, Ivana C, Giorgio R, Massimo M, Giuseppe M.(PubMed)
(f) Fruit and vegetable consumption, intake of micronutrients, and benign prostatic hyperplasia in US men by Rohrmann S1, Giovannucci E, Willett WC, Platz EA.(PubMed)
(g) Evaluation of oxidative stress and DNA damage in benign prostatic hyperplasia patients and comparison with controls by Ahmad M1, Suhail N, Mansoor T, Banu N, Ahmad S(PubMed).
(h) Oxidative stress and antioxidant status in non-metastatic prostate cancer and benign prostatic hyperplasia by Aydin A1, Arsova-Sarafinovska Z, Sayal A, Eken A, Erdem O, Erten K, Ozgök Y, Dimovski A.(PubMed)
(1) Lycopene inhibits disease progression in patients with benign prostate hyperplasia by Schwarz S1, Obermüller-Jevic UC, Hellmis E, Koch W, Jacobi G, Biesalski HK(PubMed).
(2) [Tomatoes and lycopene in prevention and therapy--is there an evidence for prostate diseases?].
[Article in German] by Ellinger S1, Ellinger J, Müller SC, Stehle P.(PubMed)(3) Effects of Serenoa repens, selenium and lycopene (Profluss®) on chronic inflammation associated with benign prostatic hyperplasia: results of "FLOG" (Flogosis and Profluss in Prostatic and Genital Disease), a multicentre Italian study by Morgia G1, Cimino S, Favilla V, Russo GI, Squadrito F, Mucciardi G, Masieri L, Minutoli L, Grosso G, Castelli T.(PubMed)
(4) Treatment of chronic prostatitis/chronic pelvic pain syndrome category IIIA with Serenoa repens plus selenium and lycopene (Profluss) versus S. repens alone: an Italian randomized multicenter-controlled study by Morgia G1, Mucciardi G, Galì A, Madonia M, Marchese F, Di Benedetto A, Romano G, Bonvissuto G, Castelli T, Macchione L, Magno C.(PubMed)
(5) Lycopene for the prevention and treatment of benign prostatic hyperplasia and prostate cancer: a systematic review by Ilic D1, Misso M(PubMed).
(8) Changes in the prevalence of benign prostatic hyperplasia in China by Gu F.(PubMed)
(9) Correlations of dietary patterns with prostate health by Stacewicz-Sapuntzakis M1, Borthakur G, Burns JL, Bowen PE.(PubMed)
(10) Benign prostatic hyperplasia: does lifestyle play a role by Barnard RJ1, Aronson WJ.(PubMed)
(11) Anthocyanin extracted from black soybean reduces prostate weight and promotes apoptosis in the prostatic hyperplasia-induced rat model by Jang H1, Ha US, Kim SJ, Yoon BI, Han DS, Yuk SM, Kim SW.(PubMed)
(12) [Effects of soy bean isoflavone on inhibition of benign prostatic hyperplasia and the expressions of NO and NOS of rats].[Article in Chinese] by Yang A1, Ren G, Tang L, Jiang W.(PubMed)
(13) [Inhibitive effect of soybean isoflavone on prostate hyperplasia in rats].[Article in Chinese] by Ren GF1, Huang YM.(PubMed)
(14) Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells by Clarke JD1, Hsu A, Yu Z, Dashwood RH, Ho E.(PubMed)
(15) Modulating testosterone stimulated prostate growth by phenethyl isothiocyanate via Sp1 and androgen receptor down-regulation by Beklemisheva AA1, Feng J, Yeh YA, Wang LG, Chiao JW.(PubMed)
(16) A phase II randomised double-blind placebo-controlled clinical trial investigating the efficacy and safety of ProstateEZE Max: a herbal medicine preparation for the management of symptoms of benign prostatichypertrophy by Coulson S1, Rao A, Beck SL, Steels E, Gramotnev H, Vitetta L.(PubMed)
(17) Phytotherapy for benign prostatic hyperplasia by Wilt TJ1, Ishani A, Rutks I, MacDonald R.(PubMed)
(18) Slowing tumorigenic progression in TRAMP mice and prostaticcarcinoma cell lines using natural anti-oxidant from spinach, NAO--a comparative study of three anti-oxidants by Nyska A1, Suttie A, Bakshi S, Lomnitski L, Grossman S, Bergman M, Ben-Shaul V, Crocket P, Haseman JK, Moser G, Goldsworthy TL, Maronpot RR.(PubMed)
(19) A case-control study of prostatic cancer with reference to dietary habits by Oishi K1, Okada K, Yoshida O, Yamabe H, Ohno Y, Hayes RB, Schroeder FH.(PubMed)
(20) Anti-androgenic activities of Ganoderma lucidum by Fujita R1, Liu J, Shimizu K, Konishi F, Noda K, Kumamoto S, Ueda C, Tajiri H, Kaneko S, Suimi Y, Kondo R.(PubMed)
(21) Administration of extract of mushroom Phellinus linteus induces prostate enlargement with increase in stromal component in experimentally developed rat model of benign prostatic hyperplasia by Shibata Y1, Kashiwagi B, Arai S, Fukabori Y, Suzuki K.(PubMed)
(22) Effect of a standardized extract of red orange juice on proliferation of human prostate cells in vitro by Vitali F1, Pennisi C, Tomaino A, Bonina F, De Pasquale A, Saija A, Tita B.(PubMed)
(23) Lycopene for the prevention and treatment of prostate disease by Ilic D.(PubMed)
(24) Effects of Serenoa repens, selenium and lycopene (Profluss®) on chronic inflammation associated with benign prostatic hyperplasia: results of "FLOG" (Flogosis and Profluss in Prostatic and Genital Disease), a multicentre Italian study by Morgia G1, Cimino S, Favilla V, Russo GI, Squadrito F, Mucciardi G, Masieri L, Minutoli L, Grosso G, Castelli T.(PubMed)
(25) [The association of Serenoa repens, lycopene and selenium is superior to Serenoa repens alone in reducing benign prostatic hyperplasia].[Article in Italian] by Squadrito F1, Morgia G.(PubMed)
(26) The effectiveness of dried cranberries ( Vaccinium macrocarpon) in men with lower urinary tract symptoms by Vidlar A1, Vostalova J, Ulrichova J, Student V, Stejskal D, Reichenbach R, Vrbkova J, Ruzicka F, Simanek V.(PubMed)
(27) Risk factors for lower urinary tract symptoms suggestive of benign prostatic hyperplasia in a community based population of healthy aging men: the Krimpen Study by Kok ET1, Schouten BW, Bohnen AM, Groeneveld FP, Thomas S, Bosch JL.(PubMed)
(28) Enteric-coated, highly standardized cranberry extract reduces risk of UTIs and urinary symptoms during radiotherapy for prostate carcinoma by Bonetta A1, Di Pierro F.(PubMed)
(29) The medicinal action of androgens and green tea epigallocatechin gallate by Liao S.(PubMed)
(30) Structure-activity relationships for inhibition of human 5alpha-reductases by polyphenols by Hiipakka RA1, Zhang HZ, Dai W, Dai Q, Liao S.(PubMed)
(31) Dietary soy and tea mitigate chronic inflammation and prostate cancer via NFκB pathway in the Noble rat model by Hsu A1, Bruno RS, Löhr CV, Taylor AW, Dashwood RH, Bray TM, Ho E.(PubMed)
(32) The medicinal action of androgens and green tea epigallocatechin gallate by Liao S.(PubMed)
(33) Risk factors for surgery for prostatic hypertrophy by Morrison AS.(PubMed)
(34) Food groups and risk of benign prostatic hyperplasia. by Bravi F1, Bosetti C, Dal Maso L, Talamini R, Montella M, Negri E, Ramazzotti V, Franceschi S, La Vecchia C.(PubMed)
(35) Benign prostatic hyperplasia: the opposite effects of alcohol and coffee intake by Gass R.(PubMed)
(36) Chronic caffeine intake increases androgenic stimuli, epithelial cell proliferation and hyperplasia in rat ventral prostate by Sarobo C1, Lacorte LM, Martins M, Rinaldi JC, Moroz A, Scarano WR, Delella FK, Felisbino SL.(PubMed)
(37) Inhibition of the experimental induction of benign prostatic hyperplasia: a possible role for fluted pumpkin (Telfairia occidentalis Hook f.) seeds by Ejike CE1, Ezeanyika LU.(PubMed)
(38) Effects of pumpkin seed oil and saw palmetto oil in Korean men with symptomatic benign prostatic hyperplasia by Hong H1, Kim CS, Maeng S.(PubMed)
(39) Inhibition of testosterone-induced hyperplasia of the prostate of sprague-dawley rats by pumpkin seed oil by Gossell-Williams M1, Davis A, O'Connor N.(PubMed)
(40) Beneficial effects of virgin coconut oil on lipid parameters and in vitro LDL oxidation. Nevin KG. Rajamohan T. Clinical Biochemistry. 37(9):830-5, 2004 Sep. [Comparative Study. Journal Article] UI: 15329324 Authors Full Name Nevin, K G. Rajamohan, T.
(41) Effects of coconut oil on testosterone-induced prostatic hyperplasia in Sprague-Dawley rats. by de Lourdes Arruzazabala M1, Molina V, Más R, Carbajal D, Marrero D, González V, Rodríguez E.(PubMed)
(42) 5 alpha-reductase-catalyzed conversion of testosterone to dihydrotestosterone is increased in prostatic adenocarcinoma cells: suppression by 15-lipoxygenase metabolites of gamma-linolenic and eicosapentaenoic acids by Pham H1, Ziboh VA.(PubMed)
(43) Comparison of fatty acid profiles in the serum of patients with prostate cancer and benign prostatic hyperplasia by Yang YJ1, Lee SH, Hong SJ, Chung BC.(PubMed)
(44) Prostate tissue and leukocyte levels of n-3 polyunsaturated fatty acids in men with benign prostate hyperplasia or prostate cancer by Christensen JH1, Fabrin K, Borup K, Barber N, Poulsen J.(PubMed)

Herbal Therapy: Topical Arnica Gel, Better Than Non-Steroidal Anti-Inflammatory Medications in Accelerated Ecchymosis Healing

Arnica may have a potential and therapeutic effect in reduced expression of Ecchymosis, some scientists suggested.

The results of these efficacy were confirmed by some studies conducted by numbers of respectable institutes, including University of Miami Miller School of Medicine and University of South Florida.

Ecchymosis is a condition of discoloration of the skin as a result of bleeding underneath. In most cases it is caused by bruising.

Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, antive to Europe and Asia, used in herbal medicine for centuries to treat strains, sprains, and bruises.
Wound healing is process of repairing after damage of skin, tissues, organs, etc.

The ingredients
Helenalin, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivative.


In order to confirm the effect of herbal Arnice activity in treatment of ecchymosis in patients who under went rhinoplasty, the most common facial plastic surgical procedure,  researchers at the joint study lead by the University of South Florida independently conducted a review of literature in databases (PubMed, SCOPUS, Embase, Web of Science, and the Cochrane database) from inception to September 2016, included studies that compared postoperative care methods (intervention groups) with no treatment (control group).

According to the final searching of 11 trials satisfied the criteria and guideline with a total of 627 patients, application of topical Arnica showed a significant effect in reduced eyelid ecchymosis during the first 7 days postoperative statistically in compared to the control group.

However, eyelid ecchymosis during the first 24 h postoperatively were statistically decreased in the cold compression group in compared to the control group.


Patients' questionnaires returned also expressed a strong satisfaction in the tapping application group than in the control group.

Also, the ratio of patient satisfaction was statistically higher in the tapping and Arnica application group than in the control group.

Additionally, the analysis also found that surgeons had a significant tendency to decrease intranasal packing in remove pain from the surgery area as the placement was found to associate with more adverse effects in terms of postoperative ecchymosis compared to non-packing.

Further differentiation to confirm the effectiveness of the combination of topical Arnica montana and Rhododendron tomentosum (Ledum palustre) in reducing postoperative ecchymosis in a select population of healthy volunteers after oculofacial surgery, researchers conducted a review examined the postoperative course of healthy volunteers using topical Arnica and Ledum after undergoing common oculofacial procedures, including blepharoplasty, browpexy, and rhinoplasty, in the hands of 4 surgeons at tertiary referral centers from July 1, 2012 to December 31, 2012 using medical records review.

A total of 27 patients (16 females, 11 males) with age range of 18 to 70 years were included in the study.

Selected medical review showed that patients included had used topical hydrogel pads (OcuMend, Cearna Inc., Chicago, IL) containing Arnica 50 M (10) 50% and Ledum 50 M (10) applied bilaterally after surgery through postoperative day 6 at each postoperative visit.

The results of everyday progression in patients were evaluated by their respective surgeons and assigned a subjective physician-patient rating score comparing each patient's observed healing compared with expected healing if not using Arnica/Ledum.

Photographs in each examination also were recorded.

The median duration of follow-up was 7 days, range from 1 to 14 days.

According to the rating of physician examined  the results, the proportions of patients with markedly accelerated healing were 38.5% (5 of 13), 85.7% (6 of 7), 60.0% (12 of 20), and 51.9% (14 of 27) at POD 1 to 2, 3 to 5, 6 to 8, and overall, respectively.

The proportions of patients with accelerated healing at the same time points were 15.4% (2 of 13), 14.3% (1 of 7), 30.0% (6 of 20), and 37.0% (10 of 27), respectively.

The proportion of patients using Arnica/Ledum with markedly accelerated healing was significantly more than the proportion of those demonstrating no appreciable difference from expected at (post operative day) POD 3 to 5 (85.7% vs. 0%, p = 0.05), POD 6 to 8 (60.0% vs. 10.0%), and overall (51.9% vs. 11.1%, p = 0.05) without inducing any adverse effects.

Dr. Lee HS, the lead author said, "The preliminary results from this study demonstrate that the combination of topical Arnica montana and Rhododendron tomentosum (Ledum palustre) may be effective in reducing postoperative ecchymosis....,after oculofacial surgery".

Taken together, topical Arnica may be considered as a functional food to accelerated the healing of ecchymosis

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN


Arthritis Is Curable

You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Assessing the Effectiveness of Arnica montana and Rhododendron tomentosum (Ledum palustre) in the Reduction of Ecchymosis and Edema After Oculofacial Surgery: Preliminary Results by Kang JY1, Tran KD, Seiff SR, Mack WP, Lee WW.(PubMed)
(2) The effectiveness of postoperative intervention in patients after rhinoplasty: a meta-analysis by Lee HS1, Yoon HY1, Kim IH1, Hwang SH2.(PubMed)
(3) Is There a Role for Arnica and Bromelain in Prevention of Post-Procedure Ecchymosis or Edema? A Systematic Review of the Literature by Ho D1, Jagdeo J, Waldorf HA.(PubMed)

Herbal Therapy: Fennel, A Potent Chemo-Preventive and Modulatory Functional Herb

Kyle J. Norton

Fennel may have a potential and positive effect in modulated the effect of chemo drugs through its chemomodulatory activity, some scientists suggested.

The expression of fennel application in enhanced chemopreventive response was evident in animal models  from the reduced tumor burden in reduced cancer cells proliferation and apoptosis and reduced percentage of tumor through some different publications.

The results were reported by several respectable institute including Jawaharlal Nehru University and published on online medical literature.

Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc

According to the Jawaharlal Nehru University, in evaluate the chemopreventive effect of different doses of test diet of Foeniculum vulgare Mill (Fennel) seeds on DMBA-induced skin and B(a)P-induced forestomach papillomagenesis in Swiss albino mice, application of fennel seeds displayed a significant reduction in the skin and the forestomach tumor incidence and tumor multiplicity as compared to the control group.

Biochemical assays showed a significant increase in the content/activities of phase I and II enzymes especially in the case of 6% test diet, in detoxify poisonous compounds caused by injection of DMBA, through significant enhancement of antioxidant activities.

Further examination also found that injection of fennel seed stimulated production of antioxidant enzyme in the body tissue in repaired damage precipitated by peroxidation through lactate dehydrogenase activity.

Dr. Singh B, the lead author said, "A significant enhancement in the activities of antioxidant enzymes were observed especially at 4% and 6%" and "glyoxalase I(with function as enzymatic defence against glycation) activity and the content of reduced glutathione (antioxidant) were significantly elevated".

Additionally, in the examine the effect of fennel bioactive compound anethole in chemomodulatory activity against the onset and spread of cancer, researchers found that application of fennel oil by inhibited the activated expression of NF-kappa B, a gene-altering and inflammation in triggering molecule in development of various solid tumors through stimulated cancer proliferation.

Also, anethole injection reduced levels of tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin), a cell signaling protein (cytokine) involved in systemic inflammation and one of the cytokines that make up the acute phase reaction. However, at a certain stage of cancer, gene expression in promoted cancer apoptosis is alternated,  TNF changes from a cancer killer to a cancer promoter.

Additionally, with abundant fiber, fennel demonstrated a strong effect in removal of toxins from the colon and therefore may be helpful in colon cancer prevention.

Dr. After taking into account of other co and confounders said, " Fennel contains flavonoid anti-oxidants compounds like kaempferol and quercetin which helps eliminate harmful free radicals from the body....".

In other words, fennel exerted chemomodulatory activity also through its flavonoid anti-oxidants compounds like kaempferol and quercetin in inhibited over expression of free radicals and free radical chain reactive in protected against cytotoxicity in induction cells damage and alternated cell DNA in facilitated onset of cancer.

Taking altogether, fennel and its bioactive compound may be considered as a chemo preventive and modulatory functional food for reduced risk and treatment of various types of cancers.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN


Natural Medicine for Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Chemomodulatory action of Foeniculum vulgare (Fennel) on skin and forestomach papillomagenesis, enzymes associated with xenobiotic metabolism and antioxidant status in murine model system by Singh B1, Kale RK(PubMed)
(2) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
(3) Arzoo and Milind Parle, Pharmacology Division, Department of Pharm. Sciences, Guru Jambheshwar University of Science and Technology(EUROPEAN JOURNAL OF PHARMACEUTICALAND MEDICAL RESEARCH)

Why You Should Eat Fennel At Least Once A Month to Detox Your Body, Public Medical Library Revealed

Kyle J. Norton


Fennel may have a potential and positive effect in excess water and toxin from body, some scientists suggested.


The result were reported on online medical literature conducted by some respectable institutes, including John Wiley & Sons, Ltd . and UFR Physiologie-Pharmacologie over different aspects via numbers of mechanisms.

Diuresis is a medicine in the stimulation of increased production of urine.


Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...


Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.

In animal model, according to the John Wiley & Sons, Ltd. in the evaluation of the retoxic effect of ydroalcohol extracts of Foeniculum vulgare var dulce (D.C) root, application of the extract exerted a significant activities in flushing out of excess water and toxin from body through increased kidney function in secretion of the urine.

The result of these properties was observed by an increase in urine flow and urinary sodium excretion.

The efficacy in cleansing body was also found linearly in dose depending manner.

Continuously, in further examine the efficacy of fennel powder, extract and oil on gentamicin induced nephrotoxicity through an study of total 35 adult female sprague Dawley rats classified into five groups with first group kept on standard diet all over the period of the experiment. and the other groups administered gentamicin (100 mg/kg/day for 7 days i.p), followed by either control (+ve) group or treated groups with fennel powder, extract and oil for 45 days, at the end of study, researchers found that

* Injected gentamicin group served as control exhibited a strong nephrotoxicity manifested by increase levels of kidney function indicator, serum nitric oxide (NO) and kidney malondialdyde (MDA) however, this group of rats also exerted a significant decrease in weight gain.

Increased expression of serum nitric oxide (NO) and kidney malondialdyde (MDA) is an indicators of severed oxidative stress caused by imbalanced of ration of ROS and antioxidants in the host.

* Gentamicin groups treated with fennel powder, extract and oil demonstrated an improve the levels of urea and uric acid in comparing to control (+ve) and displayed an improvement of antioxidant enzymes as increase of serum superoxide dismutase(SOD), catalase, and glutathione transferase (GST) and decrease of serum NO in compared to control (+ve) group.

These results addressed the important antioxidant effect of fennel extracts. Applications not only inhibited the levels of free radical and theirs' chain reactive activities but also stimulated production of antioxidants found in the host tissue.

* Moreover, group treated with fennel oil restore the normal values of kidney antioxidant enzymes compared with normal group and other treatment groups.

Dr. Soheir Ahamed Al-Masri, the lead author, after taking into account of other co and con founders said, "fennel powder, extract and oil have a potent antioxidant and ameliorate in rats gentamicin induced nephrotoxicity in rats".

Clearly, fennel oil exhibited the greatest effect in stimulated kidney function in detox the body toxins through increased secretion of urine in compared to other experimental group.

The results of this study clearly indicate that fennel powder, extract and oil have a potent antioxidant and ameliorate in rats gentamicin induced nephrotoxicity in rats. [Soheir Ahamed Al-Masri and Waffa, Sh. Ali. The Ameliorating

Interestingly, in spontaneously hypertensive rats (SHR) treated with either water extract of Marrubium vulgare L. or Foeniculum vulgare L. in normotensive Wistar-Kyoto rats (WKY), researchers showed that application of fennel water extract reduced hypertension through Foeniculum increased water, sodium and potassium excretion in compared to non effect of Marrubium treated group.

Additionally, in compared to Marrubium extract in reduced hypertenion through inhibited contractile responses, fennel restored the normal; blood pressure by increased urine secretion and ameliorated the over expression of ROS and increased antioxidant status in the host.


Surely, one can says that Foeniculum acts mainly as a diuretic and a natriuretic while Marrubium displays vascular relaxant activity.

Taken together, fennel and its extracts may be considered as a detox functional food in getting rid of body toxins through its diuretic activities.


For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN

Natural Medicine for Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve Optimal Health And Loose Weight


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography

Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Diuretic action of hydroalcohol extracts oilFoeniculum vulgare var dulce (D.C.) roots in rats by
D. Beaux, J. Fleurentin and F. Mortier(Wiley Online Library)
(2) The Ameliorating Effects of Fennel Powder, Extract and Oil on Gentamicin Induced Nephrotoxicity in Rats 1 Soheir Ahamed Al-Masri and 2 Waffa, Sh. Ali( Journal of American Science)
(3) Pharmacological evidence of hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rat by El Bardai S1, Lyoussi B, Wibo M, Morel N.(PubMed)

(2)

Food Therapy: Fennel and Its Extracts in Detoxed Body Toxins, According to PubMed Online Literature

Kyle J. Norton

Fennel may have a potential and positive effect in excess water and toxin from body, some scientists suggested.

The result were reported on online medical literature conducted by some respectable institutes, including John Wiley & Sons, Ltd . and UFR Physiologie-Pharmacologie over different aspects via numbers of mechanisms.
Diuresis is a medicine in the stimulation of increased production of urine.

Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.


In animal model, according to the John Wiley & Sons, Ltd. in the evaluation of the retoxic effect of ydroalcohol extracts of Foeniculum vulgare var dulce (D.C) root, application of the extract exerted a significant activities in  flushing out of excess water and toxin from body through increased kidney function in secretion of the urine.

The result of these properties was observed by an increase in urine flow and urinary sodium excretion.

The efficacy in cleansing body was also found linearly in dose depending manner.

Continuously, in further examine the  efficacy of fennel powder, extract and oil on gentamicin induced nephrotoxicity through an study of  total 35 adult female sprague Dawley rats classified into five groups with first group kept on standard diet all over the period of the experiment. and the other groups administered gentamicin (100 mg/kg/day for 7 days i.p), followed by either control (+ve) group or treated groups with fennel powder, extract and oil for 45 days, at the end of study, researchers found that

* Injected gentamicin group served as control exhibited a strong nephrotoxicity manifested by increase levels of kidney function indicator, serum nitric oxide (NO) and kidney malondialdyde (MDA) however, this group of rats also exerted a significant decrease in weight gain. 

Increased expression of serum nitric oxide (NO) and kidney malondialdyde (MDA) is an indicators of severed oxidative stress caused by imbalanced of ration of ROS and antioxidants in the host.

* Gentamicin groups treated with fennel powder, extract and oil demonstrated an improve the levels of urea and uric acid in comparing to control (+ve) and displayed an improvement of antioxidant enzymes as increase of serum superoxide dismutase(SOD), catalase, and glutathione transferase (GST) and decrease of serum NO in compared to control (+ve) group.

These results addressed the important antioxidant effect of fennel extracts. Applications not only inhibited the levels of free radical and theirs' chain reactive activities but also stimulated production of antioxidants found in the host tissue.

*  Moreover, group treated with fennel oil restore the normal values of kidney antioxidant enzymes compared with normal group and other treatment groups.

Dr. Soheir Ahamed Al-Masri, the lead author, after taking into account of other co and con founders said, "fennel powder, extract and oil have a potent antioxidant and ameliorate in rats gentamicin induced nephrotoxicity in rats".

Clearly, fennel oil exhibited the greatest effect in stimulated kidney function in detox the body toxins through increased secretion of urine in compared to other experimental group.

The results of this study clearly indicate that fennel powder, extract and oil have a potent antioxidant and ameliorate in rats gentamicin induced nephrotoxicity in rats. [Soheir Ahamed Al-Masri and Waffa, Sh. Ali. The Ameliorating

Interestingly, in spontaneously hypertensive rats (SHR) treated with either water extract of Marrubium vulgare L. or Foeniculum vulgare L. in normotensive Wistar-Kyoto rats (WKY), researchers showed that application of fennel water extract reduced hypertension through Foeniculum increased water, sodium and potassium excretion in compared to non effect of Marrubium treated group.

Additionally, in compared to Marrubium extract in reduced hypertenion through inhibited contractile responses, fennel restored the normal; blood pressure by increased urine secretion and ameliorated the over expression of ROS and increased antioxidant status in the host.

Surely, one can says that Foeniculum acts mainly as a diuretic and a natriuretic while Marrubium displays vascular relaxant activity. 

Taken together, fennel and its extracts may be considered as a detox functional food in getting rid of body toxins through its diuretic activities.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN


Arthritis Is Curable

You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half 

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Diuretic action of hydroalcohol extracts oilFoeniculum vulgare var dulce (D.C.) roots in rats by
D. Beaux, J. Fleurentin and F. Mortier(Wiley Online Library)
(2) The Ameliorating Effects of Fennel Powder, Extract and Oil on Gentamicin Induced Nephrotoxicity in Rats 1 Soheir Ahamed Al-Masri and 2 Waffa, Sh. Ali( Journal of American Science)
(3) Pharmacological evidence of hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rat by El Bardai S1, Lyoussi B, Wibo M, Morel N.(PubMed)
(2)

Researchers Found A Supplement in Inhibited Hair Loss and Promoted Hair Density In Women

Kyle J. Norton

Researchers may have a single ingredient for treatment of female hair loss pattern.

Supplementation with specific omega 3 & 6 and antioxidants acts efficiently against hair loss in improving hair density and reducing the telogen percentage and the proportion of miniaturized anagen hair.

Omega-3& 6 fatty acids are phytochemincals in the class of lipids, found abundantly in dark-green leafy vegetables, grains, legumes, nuts,...

Human have to absorb Omega 3 & 6 from other sources as we do not produce them.

In the total of 120 healthy female subjects participated in this 6-month, randomized, comparative study to evaluate the change in hair density on standardized photographs primary with. secondary endpoints to include changes in telogen hair percentage and diameter distribution of anagen hair (>40 µm vs. ≤40 µm) measured by trichogram, researchers found that intake of omega 3 & 6 and antioxidants display a significant effect in reduced hair loss and promoted hair growth.

According to the photograph assessment, the application demonstrated a superior improvement in hair density.

The telogen hair percentage was significantly (P < 0.001) reduced in the supplemented group.

The proportion of nonvellus anagen hair (>40 µm) increased compared to the control group.

Trichometer index in supplemented group expressed a substantial increment in compared to loss in control group.

At the end of the experience, Dr. Le Floc'h C, the led author said, "A large majority of supplemented subjects reported a reduction in hair loss (89.9% of subjects at 6 months), as well as an improvement in hair diameter (86.1%) and hair density (87.3%)".

Truly, the study of 6-month supplementation with omega 3&6 and antioxidants no doubt expressed a significant effect in inhibited hair loss and improved hair density and reduced telogen percentage and   miniaturized proportion of anagen hair.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources

(1) Effect of a nutritional supplement on hair loss in women by Le Floc'h C1, Cheniti A, Connétable S, Piccardi N, Vincenzi C, Tosti A.(PubMed)