Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals : April 2016

Saturday, 30 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The top anti inflammatory Foods - Ginger

2.6. Ginger
Ginger is the genus Zingiber, belongings to the family Zingiberaceae, native to Tamil, used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc. According to the VIT University, Trikatu, a herbal compound including ginger exhibited significant analgesic, anti-pyretic and anti-inflammatory effect against gout through precipitation of monosodium urate crystals in the joints(206).

Dr. Sabina EP and professors also at the VIT University, in the evaluation of 6-Shogaol isolated active principle from ginger suggested that application of 6-Shogaol attenuated the increased significantly the levels of lysosomal enzymes, lipid peroxidation, and inflammatory mediator tumour necrosis factor-alpha and paw volume and improved the activities of anti-oxidant status in monosodium urate crystal-induced mice(207).

References

(206) Trikatu, a herbal compound that suppresses monosodium urate crystal-induced inflammation in rats, an experimental model for acute gouty arthritis by Murunikkara V1, Rasool M.(PubMed)

(207) 6-Shogaol inhibits monosodium urate crystal-induced inflammation--an in vivo and in vitro study by Sabina EP1, Rasool M, Mathew L, Ezilrani P, Indu H.(PubMed)

Friday, 29 April 2016

Most Common Disease of50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The top anti inflammatory Foods - Onion

2.5. Onion
Onion is a plants in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures. According to the Universidad Nacional de Cuyo, garlic (G) and onion (O) exhibited anti-inflammatory properties through antioxidant in attenuated oxidative stress(203) as well as (poly)phenols altered cytokine release, in protection against age-related inflammation and chronic diseases, including gout(204).

In fact, Quercetin, a flavonoid found in high levels in onions lowers blood uric acid in humans in 4 weeks, in dose dependent-manner, according to a randomised, double-blinded, placebo-controlled, cross-over trial.(205).

Thursday, 28 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The top anti inflammatory Foods - Shiitake mushroom

The top anti inflammatory Foods

2.4. Shiitake mushroom
Shiitake mushroom is an edible mushroom, genus Lentinula, belongings to family Marasmiaceae, native to East Asia and widely cultivated for consumption for its health benefits and commercial purpose in many Asian countries. According to the joint study led by the University of Florida, intake of Shiitake mushroom improved immunity, through cell proliferation and activation and increased sIgA production, reduced inflammation via cytokine and serum CRP levels(200). Dr. Urano W and colleagues at the Tokyo Women's Medical University said, "Decrease in SUA during acute gouty arthritis is associated with increased urinary excretion of uric acid; an inflammatory process may play a role in the mechanism"(201).

The effect of Shiitake mushroom on Interleukin-6 (IL-6), a monokine with a number of biological activities, are intimately related to inflammatory responses in ameliorated serum uric acid (SUA) and increased uric acid excretion(201)(202).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

References
(200) Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults by Dai X1, Stanilka JM1, Rowe CA1, Esteves EA2, Nieves C Jr1, Spaiser SJ1, Christman MC3, Langkamp-Henken B1, Percival SS1.(PubMed)
(201) The inflammatory process in the mechanism of decreased serum uric acid concentrations during acute gouty arthritis by Urano W1, Yamanaka H, Tsutani H, Nakajima H, Matsuda Y, Taniguchi A, Hara M, Kamatani N.(PubMed)
(202) Interleukin-6 (IL-6) in synovial fluid and serum of patients with rheumatic diseases by Swaak AJ1, van Rooyen A, Nieuwenhuis E, Aarden LA.(PubMed)

Wednesday, 27 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The top anti inflammatory Foods - Green Tea

The top anti inflammatory Foods

2.3. Green Tea
Green tea, a precious drink in traditional Chinese culture has been served exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now was cultivated all over the world in suitable climate. According to the Naresuan University Hospital, dietary of green tea is associated to attenuate risk of of yugout(197), through its effect on lower SUA level and decreases uric acid clearance via significantly elevated serum antioxidant capacity(198).

Dr. L'Allemain G said, in the study of the effect of Epigallo catechin-O-gallate (EGCG), the most active epicatechin in green tea, "although no direct molecular target has been so far elucidated for EGCG, the multi-potentialities of this molecule, along with its broad bioavailability, render it very attractive as a putative curative drug for various diseases such as dermatosis, gout, atherosclerosis and cancer" and "Its anti-oxidant properties could explain its antagonistic action in some inflammatory processes"(199)

References

(197) The association of vitamin C, alcohol, coffee, tea, milk and yogurt with uric acid and gout by Towiwat P1, Li ZG2(PubMed)
(198) Effects of green tea extract on serum uric acid and urate clearance in healthy individuals by Jatuworapruk K1, Srichairatanakool S, Ounjaijean S, Kasitanon N, Wangkaew S, Louthrenoo W.(PubMed)
(199) [Multiple actions of EGCG, the main component of green tea].[Article in French] by L'Allemain G1.(PubMed)

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The top anti inflammatory Foods - Turmeric

The top anti inflammatory Foods

2.2. Turmeric
Turmeric with the similar property as garlic in enhancing immune system fighting against inflammation caused by either free radicals and foreign invasion(191). Recent study suggested, IL-1β inhibited by turmeric(195) is a potent proinflammatory cytokine of the innate immune system involved in host defense against infection. may increase production of IL-1β which plays a pathogenic role in various inflammatory diseases, such as rheumatoid arthritis, gout(194).

In animal with gout study, there was a positive correlation between intra-articular macrophage migration inhibitory factor involved in increased synovial fluid of patients with acute gout and IL-1β concentration(196).

According to the joint study led by the Federal University of Technology and China Pharmaceutical University, turmeric (Curcuma longa) exhibited effects on enzyme activities of purinergic and cholinergic systems as well as inflammatory cytokine levels(192). including including interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α)(192) through inhibiting the xanthine oxidase (XOD) activity related to amelioration of urinary uric acid (Uur) level(193).

References

(191) Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa)
by Chainani-Wu N1.(PubMed)

(192) Effect of Ginger and Turmeric Rhizomes on Inflammatory Cytokines Levels and Enzyme Activities of Cholinergic and Purinergic Systems in Hypertensive Rats by Akinyemi AJ1, Thomé GR2, Morsch VM2, Bottari NB2, Baldissarelli J2, de Oliveira LS2, Goularte JF3, Belló-Klein A3, Duarte T4, Duarte M4, Boligon AA5,Athayde ML5, Akindahunsi AA1, Oboh G1, Schetinger MR2.(PubMed)
(193) Study on the anti-gout activity of chlorogenic acid: improvement on hyperuricemia and gouty inflammation by Meng ZQ1, Tang ZH, Yan YX, Guo CR, Cao L, Ding G, Huang WZ, Wang ZZ, Wang KD, Xiao W, Yang ZL.(PubMed)

(194) Phosphocholine-Modified Macromolecules and Canonical Nicotinic Agonists Inhibit ATP-Induced IL-1β Release by Hecker A1, Küllmar M1, Wilker S1, Richter K2, Zakrzewicz A1, Atanasova S1, Mathes V1, Timm T3, Lerner S1, Klein J4, Kaufmann A5, Bauer S5, Padberg W1,Kummer W6, Janciauskiene S7, Fronius M8, Schweda EK9, Lochnit G3, Grau V10.(PubMed)

(195) Anti-inflammatory effect of curcumin on mast cell-mediated allergic responses in ovalbumin-induced allergic rhinitis mouse by Zhang N1, Li H1, Jia J2, He M3.(PubMed)

(196) Macrophage migration inhibitory factor drives neutrophil accumulation by facilitating IL-1β production in a murine model of acute gout by Galvão I1, Dias AC1, Tavares LD2, Rodrigues IP1, Queiroz-Junior CM3, Costa VV2, Reis AC3, Ribeiro RD4, Louzada-Junior P4, Souza DG2, Leng L5, Bucala R5, Sousa LP6, Bozza MT7, Teixeira MM8, Amaral FA9.(PubMed)

Tuesday, 26 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The top anti inflammatory Foods - Garlic

The top anti inflammatory Foods

The top 5 anti inflammatory foods in reduced risk of over expression of pro inflammatory cytokine are always important to prevent the early onset and patient with gout as well as the expression of cardiovascular and renal risks(190).

2.1. Garlic

Inflammation plays an important roles in the early onset of uric acid involved the develop of gout. Dr. Perez-Ruiz F and Dr, Becker MA suggested, inflammation may provide a mechanistic explanation, related to some important chronic co-morbidities remains uncertain(189).

According to the joint study led by the Instituto de Neurobiología, alliin, a garlic (Allium sativum) compound inhibited the exprssion of LPS-induced inflammation(186) in 3T3-L1 adipocytes(187), involved decreasing serum levels of glucose, insulin, triglycerides, and uric acid, as well as insulin resistance, and cytokine levels(187).

Dr. Percival S. said, "Garlic contains numerous compounds that have the potential to influence immunity. Immune cells, especially innate immune cells, are responsible for the inflammation necessary to kill pathogens. Two innate lymphocytes, γδ-T and natural killer (NK) cells, appear to be susceptible to diet modification"(188).

References

(186) Purified aged garlic extract modulates allergic airway inflammation in BALB/c mice by Zare A1, Farzaneh P, Pourpak Z, Zahedi F, Moin M, Shahabi S, Hassan ZM.(PubMed)
(187) Alliin, a garlic (Allium sativum) compound, prevents LPS-induced inflammation in 3T3-L1 adipocytes by Quintero-Fabián S1, Ortuño-Sahagún D2, Vázquez-Carrera M3, López-Roa RI4.(PubMed)
(188) Aged Garlic Extract Modifies Human Immunity by Percival SS1.(PubMed)
(189) Inflammation: a possible mechanism for a causative role of hyperuricemia/gout in cardiovascular disease by Perez-Ruiz F1, Becker MA2.(PubMed)
(190) Detrimental role of hyperuricemia on the cardio-reno-vascular system by Stack A1, Manolis AJ2, Ritz E3.(PubMed)

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The Do’s and Do not’s list

The Prevention and Management

The Do’s and Do not’s list
1. Coffee
Researchers found that long-term moderate coffee consumption is associated with a lower risk of incident gout, particular in women(139). According to the joint study led by the Naresuan University Hospital, there is an associations between vitamin C, alcohol,coffee, tea, milk and yogurt with uric acid and the risk of gout(140).
In Japanese men and women aged 49-76 years, "There were inverse associations of coffee consumption with serum UA concentrations and hyperuricemia in men regardless of adjustment for covariates" Said by Dr. Pham NM and colleagues at the Kyushu University(141).

2. Maintaining adequate fluid intake, particular at night
Dehydrate is associated with the increased risk of gout, particular at night time, epidemiological study suggested(142). Drinking water or skim milk can improve gout control, according to findings from two studies that highlight the important contribution of lifestyle factors on gout prevention and management(144), and recent use of diuretics is associated with a significantly increased risk for recurrent gouty arthritis(143).

3. Weight reduction
Obesity cause cause pressure to the joint. Obesity is not only a risk factor for incident gout but is associated with an earlier age at gout onset(147). According to the a total of 543 cases of juvenile gout from the Ho-Ping Gout Database and 5269 gouty cases with onset age of 40 to 50 years, family history of overweight and hereditary background are significantly associated to increased risk of juvenile gout(145).
Dr. Lee J and the research team at the The Catholic University of Korea, said," Gout is a chronic inflammatory disease the development of which is associated with obesity-induced metabolic abnormalities."(146).

In deed, women with early- and mid-adult life obesity, high mid-adult life waist-to-hip ratios, and adulthood high weight gain, experience a greater incidence of gout, according to Johns Hopkins University School of Medicine(148).

4. Dietary and life style pattern changes
a. Reduce alcohol
Alcohol intake is strongly associated with an increased risk of gout. This risk varies substantially according to type of alcoholic beverage: beer confers a larger risk than spirits, whereas moderate wine drinking does not increase the risk(150). The association between excessive alcohol consumption and risk of gout has been suspected since ancient times which was confirmed by the study by the Harvard Medical School, Boston(149).
Unfortunate to alcohol drinker, regardless of type of alcoholic beverage, episodic alcohol consumption,was associated with an increased risk of recurrent gout attacks, including potentially with moderate amounts(151).

b. Reduce intake of foods with high levels of purine, such as sardines, herring, kidney and sweetbreads, shrimp, etc.(152). According to the Third National Health and Nutrition Examination Survey, in the review of the data from 14,809 participants (6,932 men and 7,877 women) ages 20 years and older for the years 1988-1994, higher levels of meat and seafood consumption are associated with higher serum levels of uric acid(153) and sugar-sweetened soft drink consumption is associated with serum uric acid levels and frequency of hyperuricemia(154).

c. Diet with foods to prevent gout
Dairy products, vegetables, nuts, legumes, fruits (less sugary ones), and whole grains are healthy choices for the comorbidities of gout and may also help prevent gout by reducing insulin resistance(156). Coffee and vitamin C(155) supplementation could be considered as preventive measures as these can lower urate levels, as well as the risk of gout and some of its comorbidities(156).
Diet with foods such as cherries and strawberries to prevent gout(157), as evidence of the impact of strawberry intake on gout has been report(157).

5. Reduce intake of medications which can cause gout and recurrent gout by reviewing them with your doctor, as certain medicine such as Thiazide and loop diuretics(158).

6. Exercise
Regular physical exercise is associated to reduce risk of gout(159).
“Exercises to relieve gout should be done steady and cautiously as to avoid further irritation to the joints. The best exercises for gout are range of motion types: strength training, stretching and building endurance. Yoga is an exercise that incorporates all four; however, there are other exercises that can be done individually also” According to the article of How to Exercise If You Have Gout(160).

References
(139) Coffee consumption and risk of incident gout in women: the Nurses' Health Study by Choi HK1, Curhan G.(PubMed)
(140) The association of vitamin C, alcohol, coffee, tea, milk and yogurt with uric acid and gout by Towiwat P1, Li ZG2.(PubMed)
(141) The relation of coffee consumption to serum uric Acid in Japanese men and women aged 49-76 years by Pham NM1, Yoshida D, Morita M, Yin G, Toyomura K, Ohnaka K, Takayanagi R, Kono S.(PubMed)
(142) Nocturnal Risk of Gout Attacks by Hyon K. Choi, MD, DrPH,1 Jingbo Niu, MD, DSc,1 Tuhina Neogi, MD, PhD, FRCPC,1 Clara A. Chen, MHS,1 Christine Chaisson, MPH,1 David Hunter, MBBS, PhD,2 and Yuqing Zhang, DSc1(PMC)
(143) Recent diuretic use and the risk of recurrent gout attacks: the online case-crossover gout study by Hunter DJ1, York M, Chaisson CE, Woods R, Niu J, Zhang Y.(PubMed)
(144) Water, Skim Milk Consumption May Improve Gout Control By: AMY ROTHMAN SCHONFELD JANUARY 1, 2010,(Eheumatology News)
(145) Juvenile gout in Taiwan associated with family history and overweight by Chen SY1, Shen ML.(PubMed)
(146) Visceral fat obesity is highly associated with primary gout in a metabolically obese but normal weighted population: a case control study by Lee J1, Lee JY2, Lee JH3, Jung SM4, Suh YS5, Koh JH6, Kwok SK7, Ju JH8, Park KS9, Park SH10.(PubMed)
(147) Obesity and younger age at gout onset in a community-based cohort by DeMarco MA1, Maynard JW, Huizinga MM, Baer AN, Köttgen A, Gelber AC, Coresh J.(PubMed)
(148) Incident gout in women and association with obesity in the Atherosclerosis Risk in Communities (ARIC) Study by Maynard JW1, McAdams DeMarco MA, Baer AN, Köttgen A, Folsom AR, Coresh J, Gelber AC.(PubMed)
(149) Alcohol intake and risk of incident gout in men: a prospective study by Choi HK1, Atkinson K, Karlson EW, Willett W, Curhan G.(PubMed)
(150) Alcohol intake and risk of incident gout in men: a prospective study by Choi HK1, Atkinson K, Karlson EW, Willett W, Curhan G.(PubMed)
(151) Alcohol quantity and type on risk of recurrent gout attacks: an internet-based case-crossover study by Neogi T1, Chen C2, Niu J3, Chaisson C2, Hunter DJ4, Zhang Y3.(PubMed)
(152) Purine-rich foods, dairy and protein intake, and the risk of gout in men by Choi HK1, Atkinson K, Karlson EW, Willett W, Curhan G.(PubMed)
(153) Intake of purine-rich foods, protein, and dairy products and relationship to serum levels of uric acid: the Third National Health and Nutrition Examination Survey by Choi HK1, Liu S, Curhan G.(PubMed)
(154) Sugar-sweetened soft drinks, diet soft drinks, and serum uric acid level: the Third National Health and Nutrition Examination Survey by Choi JW1, Ford ES, Gao X, Choi HK.(PubMed)
(155) A prescription for lifestyle change in patients with hyperuricemia and gout by Choi HK1.(PubMed)
(156) A prescription for lifestyle change in patients with hyperuricemia and gout by Choi HK1.(PubMed)
(157) Impact of strawberries on human health: insight into marginally discussed bioactive compounds for the Mediterranean diet by Tulipani S1, Mezzetti B, Battino M.(PubMed)
(158) Use of diuretics and risk of incident gout: a population-based case-control study by Bruderer S1, Bodmer M, Jick SS, Meier CR.(PubMed)
(158) Recent diuretic use and the risk of recurrent gout attacks: the online case-crossover gout study. by Hunter DJ1, York M, Chaisson CE, Woods R, Niu J, Zhang Y.(PubMed)
(159) Effects of diet, physical activity and performance, and body weight on incident gout in ostensibly healthy, vigorously active men by Paul T Williams(PubMed)
(160) How to Exercise If You Have Gout by Sequoia

Monday, 25 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The Misdiagnosis and delay diagnosis

The Misdiagnosis and delay diagnosis

According to the University of Kansas School of Medicine, out of 9,108 consecutive new patients seen in an outpatient rheumatology clinic, 155 (1.7%) diagnosed as having gout, 164 (1.8%) had been incorrectly diagnosed as having gout in the community(131).

"The main factors potentially contributing to delayed diagnosis after consultation included reported misdiagnosis, attacks in joints other than the first metatarsophalangeal joint, and female gender. The limitations in using serum uric acid (SUA) levels for diagnostic purposes were not always communicated effectively to patients, and led to uncertainty and lack of confidence in the accuracy of the diagnosis", the Keele University insisted(134).

1. Rheumatoid arthritis

In elderly, polyarticular gout may be misdiagnosed due to confusing clinical presentation of "diuretic gout" such as polyarticular onset, subacute symptoms. ......According to the Albert Einstein College of Medicine, misdiagnosis of rheumatoid arthritis can induce poor treatment of gout, affecting underlying conditions of renal insufficiency, and cardiac risks(132).

2. Elderly-onset gout (EOG)

Elderly-onset gout (EOG) is a condition of gout with onset at age 65 years or over, shared a relevant epidemiological, clinical and therapeutic differences from the typical middle-age form. According to the University of Ferrara,"EOG has recently been confirmed as the most common inflammatory arthropathy in older people, with important demographic implications and substantial impact on daily clinical practice. Despite the high prevalence, gout, in the elderly, often remains misdiagnosed or diagnosed late in its clinical course."(133).

3. Misdiagnosis due to confusing in classification

According to the Hospital Universitario Cruces, as a step-up disease, gout consists different stages: acute gout, intercritical gout, and chronic gout but in clinical practice, gout should be considered as a single disease with either or both acute (most commonly, episodes of acute inflammation) but not restricted to chronic synovitis in support the clinical manifestations and diagnosis of gout(135).

4. Recurrent gouty arthritis

There is a report of misdiagnosis of recurrent gouty arthritis associated with hyperuricemia and hyperlipidemia during adolescence. as steatohepatitis in a family with mild glycogen storage disease type 1a. National Chung Hsing University, due to the effect of result of misdiagnosis suggested that patients with mild glycogen storage disease should be considered in the adolescents with unexplained hyperuricemia and hyperlipidemia, despite the presence of normal blood glucose levels(136).

5. Chylous cysts of the neck or chest
According to the Geisinger Medical Center, there is a report of chylous cyst was misdiagnosed as recurrent chest wall gouty tophus due to form birefringent crystals upon drying(137).

6. Psoriatic arthritis
In the review of Forty-two patients with psoriatic arthritis who were referred to a tertiary medical center from 1983 to 1987, eight patients with foot and ankle involvement were diagnosed and treated for either gout or compression of a digital nerve due to failure to identify psoriatic skin lesions and the associate foot and ankle symptoms with psoriatic arthritis.(138).

References
(130) Dual-Energy Computed Tomography: Advantages in the Acute Setting by McLaughlin PD1, Mallinson P2, Lourenco P2, Nicolaou S2.(PubMed)

(131) The misdiagnosis of gout and hyperuricemia by Wolfe F1, Cathey MA.(PubMed)

(132) Misdiagnosis of rheumatoid arthritis in an elderly woman with gout by Sewell KL1, Petrucci R, Keiser HD.(PubMed)

(133) Elderly-onset gout: a review. by De Leonardis F1, Govoni M, Colina M, Bruschi M, Trotta F.(PubMed)

(134) Mapping patients' experiences from initial symptoms to gout diagnosis: a qualitative exploration. by Liddle J1, Roddy E1, Mallen CD1, Hider SL1, Prinjha S2, Ziebland S2, Richardson JC1.(PubMed)

(135) Clinical manifestations and diagnosis of gout by Perez-Ruiz F1, Castillo E2, Chinchilla SP2, Herrero-Beites AM3.(PubMed)

(136) Misdiagnosis as steatohepatitis in a family with mild glycogen storage disease type 1a by Shieh JJ1, Lu YH, Huang SW, Huang YH, Sun CH, Chiou HJ, Liu C, Lo MY, Lin CY, Niu DM.(PubMed)

(137) Misdiagnosis of a chylous cyst as chest wall gouty tophus: a case of true pseudogout by Adhikesavan LG1, Ayoub WT, Schumacher HR.(PubMed)

(138) Psoriatic arthritis of the foot and ankle: analysis of joint involvement and diagnostic errors by Hammerschlag WA1, Rice JR, Caldwell DS, Goldner JL.(PubMed)

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The Diagnosis

The Diagnosis

According to the Rockville (MD): Agency for Healthcare Research and Quality (US); 2016 Feb. Report No.: 15(16)-EHC026-EF.AHRQ Comparative Effectiveness Reviews(125).
if you are experience SHARP pain in the joint with visual symptoms of collection of urate crystal deposit and other clinical signs and symptoms of gout, your doctor may order the below tests
1. Joint fluid test
Withdraw fluid from affected joint to test for sign of urate crystal accumulation for confirmation of gout.

2. Blood test
Blood test is necessary to measure levels of uric acid for gout and creatinine for kidney function in your blood. According to the University of Auckland, measured blood test in people with gout has caused confusion about the details of urate measurement in suboptimal care(126), as the measurement may not be accurate as some some people with high levels of uric acid levels, have never experienced gout. And some people have signs and symptoms of gout, but don't have higher levels of uric acid in their blood(127).

3. X-ray imaging(125)
The aim of the test is to rule other causes of inflammation of joints. In case of negative or inconclusive, other tests such as ultrasound and dual energy CT scan to provide additional information in patients(128),

4. Ultrasound(125)
The aim is to detect any urate crystals deposit in a joint or in a tophus for confirmation of gout when X ray is inconclusive and negative(128). Dr. Codreanu C and Dr. Enache L said, "adding US to the clinical and serological features will significantly improve the sensitivity of proposed criteria. The ability of high resolution US to detect crystalline deposits of monosodium urate in joints and soft tissues is well recognized"(129)

5. Dual energy CT scan(125)
The aim of the test is to detect any any urate crystals deposit in a joint or in a tophus even without sign of acute inflammation. "Dual-energy computedtomography (CT) contributes over conventional single-energy CT,........ Particular emphasis will be placed on acute gout, bone marrow edema, acute renal colic, acute cardiovascular and neurovascular emergencies aswell as characterization of abdominal incidentalomas" according to the joint study led by the University of British Columbia.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

References

(125) Diagnosis of Gout [Internet].Editors Newberry SJ, FitzGerald J, Maglione MA, O'Hanlon CE, Han D, Booth M, Motala A, Tariq A, Dudley W, Shanman R, Shekelle PG.(PubMed)
(126) Urate testing in gout: why, when and how by Dalbeth N1, Winnard D, Gow PJ, Boswell DR, Te Karu L, Lindsay K, Arroll B, Stamp LK.(PubMed)
(127) Tests and diagnosis By Mayo Clinic Staff(127)
(128) Diagnostic imaging of gout: comparison of high-resolution US versus conventional X-ray by Rettenbacher T1, Ennemoser S, Weirich H, Ulmer H, Hartig F, Klotz W, Herold M.(PubMed)
(129) Is ultrasound changing the way we understand rheumatology? Including ultrasound examination in the classification criteria of polymyalgia rheumatica and gout by Codreanu C1, Enache L2.(PubMed)

Sunday, 24 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The Complication of Advanced gout

Kyle J. Norton (Scholar and Master of Nutrients, all right reserved)Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(*).

Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

Gout

Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.

The Complications

5. Advanced gout
Untreated gout may cause even more deposits of urate crystals to form under the skin in nodules called tophi (TOE-fie), leading to advanced gout with tophi developed in several areas, including fingers, hands, feet, elbows,.......Occasionally,untreated gout can lead to advanced arthritic changes. and chronic discomfort of the hallux MTPJ, necessitating surgical intervention to help alleviate symptoms, according to Dr. Balutis E and Dr., Pino A.(123).Refractory gout in patients who have ongoing symptoms of active disease and cannot maintain a target serum urate less than 6 mg/dl were treated successfully with long-term pegloticase treatment, improvements in clinical status, in the form of flare and tophus reduction and maintained goal range urate-lowering responses during up to 2.5 years of additional treatment(124).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References

(123) Gout Causing Isolated Sesamoid Destruction Mimicking a Neoplastic Process by Balutis E1, Pino A.(PubMed)

(124) Long-term safety of pegloticase in chronic gout refractory to conventional treatment by Becker MA1, Baraf HS, Yood RA, Dillon A, Vázquez-Mellado J, Ottery FD, Khanna D, Sundy JS.(PubMed)

Saturday, 23 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The Complication of Recurrent gout

Kyle J. Norton (Scholar and Master of Nutrients, all right reserved)Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(*).

Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

Gout

Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.

The Complications

4. Recurrent gout

Recurrent episodes of gout have shown to induce further damage to joints and other tissues from urate crystal deposition. Certain medication such as aspirin used on two consecutive days is associated with an increased risk of recurrent gout attacks(118). Purine-rich foods intake is associated to increased risk of recurrent gout after 2 days(119).
Consumption of beer, loop or thiazide diuretics, ciclosporin, tacrolimus, ethambutol, pyrazinomide, nicotinic acid, also are found stimulate the progression of recurrent gout, according to Dr. Robin Fox, GP(120). Other risk factors for recurrent gout include medical conditions such as Psoriasis Myeloproliferative disorders, Administration of cytotoxic drugs (tumour lysis syndrome), Inherited enzyme deficiencies and Lead poisoning(occupations)(120).

Fortunately, in a study of 633 individuals with gout. cherry intake over a 2-day period was associated with a 35% lower risk of gout attacks. Cherry extract intake showed a similar inverse association(121). And according to the University of Maryland School of Medicine, "primary prevention of gout can be achieved through lifestyle changes including weight loss, restricting protein and calorie intake, limiting alcohol consumption, avoiding the use of diuretics in the treatment of hypertension, and avoiding occupational exposure to lead"(122).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References

(118) Low-dose aspirin use and recurrent gout attacks by Zhang Y1, Neogi T, Chen C, Chaisson C, Hunter DJ, Choi H.(PubMed)
(119) Purine-rich foods intake and recurrent gout attacks by Zhang Y1, Chen C, Choi H, Chaisson C, Hunter D, Niu J, Neogi T.(PubMed)
(120) Management of recurrent gout by Robin Fox, GP1(PMC)
(121) Cherry consumption and decreased risk of recurrent gout attacks by Zhang Y1, Neogi T, Chen C, Chaisson C, Hunter DJ, Choi HK.(PubMed)

(122) Prevention and management of gout by Star VL1, Hochberg MC.(PubMed)

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The Complication of Joint damage

Gout

Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.

The Complications

3. Joint damage
Acute gout or acute gouty arthritis can induce joint damage thoough deposit of uric acid crystals in joint spaces. Patients with gout are associated to complication of joint damage, according to the joint study led by University of Auckland, monosodium urate crystals are frequently present in joints affected by radiographic damage in gout(115).
Dr. Dalbeth N and professors at the University of Auckland in the review of joint damage in aptients with gout, suggested that intensive urate-lowering therapy plays a critical role in improvement in structural damage, particularly bone erosion(116).

MDHAQ (Multidimensional Health Assessment Questionnaire) scores for physical function (FN), pain, Patient Global Estimate (PATGL), and RAPID3 (Routine Assessment of Patient Index Data, a composite of these 3 measures) in the examination of patients with osteoarthritis, systemic lupus erythematosus, spondyloarthropathy, and gout, similarly to rheumatoid arthritis suggested an improvement scores in patients with 5 diagnoses, according to NYU Hospital for Joint Diseases,(117).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(115) Relationship between structural joint damage and urate deposition in gout: a plain radiography and dual-energy CT study by Dalbeth N1, Aati O1, Kalluru R1, Gamble GD1, Horne A1, Doyle AJ2, McQueen FM3.(PubMed)
(116) Exploratory study of radiographic change in patients with tophaceous gout treated with intensive urate-lowering therapy by Dalbeth N1, Doyle AJ, McQueen FM, Sundy J, Baraf HS.(PubMed)
(117) MDHAQ/RAPID3 to recognize improvement over 2 months in usual care of patients with osteoarthritis, systemic lupus erythematosus, spondyloarthropathy, and gout, as well as rheumatoid arthritis by Castrejón I1, Bergman MJ, Pincus T.(PubMed)

Thursday, 21 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The Complication of Kidney stone

Gout

Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.

The Complications

2. Kidney stone
Kidney stone is a composed of mineral salts formed in the kidneys. Men account for the 80% of those with kidney stones and are at risk of the forming between 30 and 40 years of age. About 75% of kidney stones are calcium stones.

Minimally surgical intervention depends on performing the least invasive technique with the highest success of stone removal, according to Harvard Medical School(107). Others suggests that flexible ureterorenoscopy may be the first-choice treatment for stones <2cm(108).

Dr. Ahmed MH and colleagues at the Milton Keynes Hospital NHS Foundation Trust, believe that Renal stone disease and gallstone disease are the widely prevalent renal stone disease and gallstone disease across the globe, are associated with a variety of diseases including gout(110).

In a total of 396 male patients with gout and 403 age- and sex- matched healthy controls included in this study conducted by the Affiliated Hospital of Qingdao University, risk of renal calculus is increased in patient carrying the TT genotype of CARD8 rs2043211 polymorphism with gout(109).

Recent study by some well known institution suggested that the combination of Green tea(111), Grape (112) and Sweet Potato(113) smoothie may hold a key in further studies in production of an effective natural ingredients for prevention and treatment of kidney Stones without inducing adverse effects.

If you need more information of the above smoothie, please visits, The Best Smoothie of Green tea, Grape and Sweet Potato for Prevention and Treatment of Kidney Stones caused by Medullary sponge kidney(114).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(107) Minimally invasive surgical treatment for kidney stone disease by Rodríguez D1, Sacco DE2.(PubMed)
(108) Current practice in Latin America of flexible ureterorenoscopy with laser for treating kidney stones responses on a Latin American questionnaire[Article in English, Spanish] by Manzo BO1, Bertacchi M2, Lozada E3, Rasguido A4, Aleman E5, Cabrera M6, Rodríguez A7, Manzo G3, Sánchez H3, Blasco J8.(PubMed)
(109) CARD8 rs2043211 polymorphism is associated with gout in a Chinese male population by Chen Y1, Ren X, Li C, Xing S, Fu Z, Yuan Y, Wang R, Wang Y, Lv W.(PubMed)
(110) The association between renal stone disease and cholesterol gallstones: the easy to believe and not hard to retrieve theory of the metabolic syndrome by Ahmed MH1, Barakat S, Almobarak AO.(PubMed)
(111) Effects of green tea on urinary stone formation: an in vivo and in vitro study by Jeong BC1, Kim BS, Kim JI, Kim HH.(PubMed)
(112) 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose reduces renal crystallization and oxidative stress in a hyperoxaluric rat model by Lee HJ1, Jeong SJ, Lee HJ, Lee EO, Bae H, Lieske JC, Kim SH.(PubMed)

(113) Vitamin E therapy prevents hyperoxaluria-induced calcium oxalate crystal deposition in the kidney by improving renal tissue antioxidant status by Thamilselvan S1, Menon M.(PubMed)

(114) The Best Smoothie of Green tea, Grape and Sweet Potato for Prevention and Treatment of Kidney Stones caused by Medullary sponge kidney by Kyle J. Norton

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - Diseases associated with Gout - Psoriasis

Gout

Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.

Diseases associated with Gout

According to the UK Gout Society, diseases associated to gout may include

12. Psoriasis
Psoriasis is an autoimmune diseases induced abnormal skin path with expression of redness, itchy, and scaly. According to the joint study led by the University of Trieste, the increased incidence of a large number of diseases which share an inflammatory origin probably due to the pro-inflammatory cytokine spillover from active psoriatic lesions leading to a large inflammation on distant tissues(95).

Methotrexate, a conventional medicine may be an effective therapy for extensive and severe forms of psoriasis if patients are selected carefully and monitored regularly in the dose of <15-20 mg/week(96) Dr. Haustein UF and Dr. Rytter M. insisted(96).

According to the joint study led by the Brigham and Women's Hospital and Harvard Medical School, Boston, individuals with psoriasis have increased blood levels of uric acid. In the documented 2217 incident cases of gout during follow-up. Psoriasis was associated with an increased risk of subsequent gout with a multivariate HR of 1.71(97).

Dr. Lai YC and Dr.Yew YW said, " A raised serum uric acid level may be a consequence of metabolic syndrome, which in turn is associated with psoriasis"(98).

Recent studies by some renowned institutions suggested that green tea(99) and grape(100) may be the next generation of ingredient extracted from natural sources for reduced risk and treatment of psoriasis.

If you need more information of the above smoothie, please visits, The Unbelievable Smoothie Green Tea and Grape for reduced risk and Treatment of Psoriasis(101).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References

(95) Increased airway inflammation in patients with psoriasis by Damiani G1, Radaeli A2, Olivini A2, Calvara-Pinton P3, Malerba M2.(PubMed)
(96) Methotrexate in psoriasis: 26 years' experience with low-dose long-term treatment by Haustein UF1, Rytter M.(PubMed)
(97) Psoriasis, psoriatic arthritis and risk of gout in US men and women by Merola JF1, Wu S2, Han J3, Choi HK4, Qureshi AA5.(PubMed)
(98) Psoriasis and uric acid: a population-based cross-sectional study by Lai YC1, Yew YW2.(PubMed)
(99) Green tea protects against psoralen plus ultraviolet A-induced photochemical damage to skin by Zhao JF1, Zhang YJ, Jin XH, Athar M, Santella RM, Bickers DR, Wang ZY.(PubMed)

(100) Resveratrol ameliorates imiquimod-induced psoriasis-like skin inflammation in mice by Kjær TN1, Thorsen K2, Jessen N2, Stenderup K3, Pedersen SB1.(PubMed)

(101) The Unbelievable Smoothie Green Tea and Grape for reduced risk and Treatment of Psoriasis by Kyle J. Norton

Wednesday, 20 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The Complication of Tophi

Gout

Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.

The Complications

1. Tophi
Tophi is a forming of lumps building up around the joint due to chemical called uric acid. According to the University Hospital Southampton NHS Foundation Trust, tophi may be managed and treated by non-surgical and surgical procedures(102).

Allopurinol, the conventional medication, allopurinol (100 to 600 mg daily) expressed low- to moderate-quality evidence indicating similar effects on withdrawals due to adverse events (AE) and serious adverse events (SAE). and incidence of acute gout attacks in randomised controlled trials (RCTs) or quasi-randomised controlled clinical trials (CCTs)(103). And benzbromarone is probably more successful than probenecid at achieving serum urate normalisation in people with gout(104).

According to the Hospital General Universitario de Alicante, diet supplements of vitamin C, has shown to the attenuated forming of lumps on joints but the study did not assess tophus regression, pain reduction or disability or health-related quality of life impact. The study reported no adverse events and no participant withdrawal due to adverse events(105).

Furthermore, there is good evidence from observational studies of an association between various lifestyle risk factors and gout development but the The Royal Melbourne Hospital, Parkville, Australia study did not include the expression of physical function, tophus regression and serum urate normalisation(106).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References

(102) Interventions for tophi in gout by Sriranganathan MK1, Vinik O, Bombardier C, Edwards CJ.(PubMed)
(103) Allopurinol for chronic gout by Seth R1, Kydd AS, Buchbinder R, Bombardier C, Edwards CJ.(PubMed)
(104) Uricosuric medications for chronic gout by Kydd AS1, Seth R, Buchbinder R, Edwards CJ, Bombardier C.(PubMed)
(105) Dietary supplements for chronic gout by Andrés M1, Sivera F, Falzon L, Buchbinder R, Carmona L.(PubMed)
(106) Lifestyle interventions for chronic gout by Moi JH1, Sriranganathan MK, Edwards CJ, Buchbinder R.(PubMed)

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - Diseases associated with Gout - Peripheral vascular(artery) disease

Gout

Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.

Diseases associated with Gout

According to the UK Gout Society, diseases associated to gout may include

11. Peripheral vascular(artery) disease
Peripheral vascular disease is a condition of poor circulation of blood, affecting the functions of heart and brain. Because of of its implication involving risk of myocardial infarction, stroke, and cardiovascular death and impaired quality of life, some researchers suggested of the importance in identified patients with PAD have become necessary(91). According to the a large cohort of primary care patients, patients with gout are associated to increase risk of vascular disease, particular in female patients with gout(92).
Dr. Baker JF and colleagues at the University of Pennsylvania said, " in multivariate model, a history of gout was associated with an odds ratio of 1.33. Serum uric acid level is independently associated with a higher (but statistically nonsignificant) risk of PAD"(93).

In the study involved classical risk factors and rheological profile of patients suffering from vascular disease of. 364 patients out of a total of 2,498 individuals suffered from vascular disease, the University of Saarland study insisted that patients with gout and metabolic syndrome are associated to elevated risk of peripheral vascular disease(94).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References

(91) Peripheral Artery Disease: Evolving Role of Exercise, Medical Therapy, and Endovascular Options by Olin JW1, White CJ2, Armstrong EJ3, Kadian-Dodov D4, Hiatt WR5(PubMed)

(92) Increased risk of vascular disease associated with gout: a retrospective, matched cohort study in the UK clinical practice research datalink by Clarson LE1, Hider SL1, Belcher J1, Heneghan C2, Roddy E1, Mallen CD1.(PubMed)

(93) Serum uric acid level and risk for peripheral arterial disease: analysis of data from the multiple risk factor intervention trial by Baker JF1, Schumacher HR, Krishnan E.(PubMed)

(94) Prevalence, risk factors and rheological profile of arterial vascular disease; first results of the Aachen study by Kiesewetter H1, Jung F, Kotitschke G, Nüttgens HP, Witt R, Winkelhog C, Ladwig KH, Waterloh E, Roebruck P, Schneider R, et al.(PubMed)

Tuesday, 19 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - Diseases associated with Gout - Stroke

Gout

Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.

Diseases associated with Gout

According to the UK Gout Society, diseases associated to gout may include

9. Stroke
Besides cancer and heart diseases, stroke is the third leading cause of death. Approximate 1/4 of all stroke victims die as a direct result of the stroke or it's complications. Stroke is caused by uncontrolled diet that is high in saturated and trans fats resulting in cholesterol build up in the arteries and high blood pressure.

In the review of all-England dataset included 202 033 hospital patients and all-England national linked dataset of hospital admissions and death records from 1999 to 2011, the University of Oxford, strongly confirmed that gout was associated with increased risk of stroke(85).

Dr. Grassi W and Dr. De Angelis R. in the analyzed clinical features of gout. found that gouty patients often have a medical history, including stroke, resulting with a poor overall quality of life(86).

This finding of the effectiveness of Green Tea(87) and coffee(88) and blueberry(89) phytochemicals in recent studies by some respectable institutions may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk treatment of stroke with little or no adverse effects.

If you need more information of above finding, please visit The incredible smoothie Green Tea, Coffee and Blueberry for reduced risk and treatment of Stroke(90).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
References

(85) Gout as a risk factor for myocardial infarction and stroke in England: evidence from record linkage studies by Seminog OO1, Goldacre MJ.(PubMed)

(86) Clinical features of gout by Grassi W1, De Angelis R.(PubMed)

(87) The impact of green tea and coffee consumption on the reduced risk of stroke incidence in Japanese population: the Japan public health center-based study cohort by Kokubo Y1, Iso H, Saito I, Yamagishi K, Yatsuya H, Ishihara J, Inoue M, Tsugane S.(PubMed)

(88) Coffee and tea consumption and risk of stroke subtypes in male smokers by Larsson SC1, Männistö S, Virtanen MJ, Kontto J, Albanes D, Virtamo J.(PubMed)

(89) Diets containing blueberry extract lower blood pressure in spontaneously hypertensive stroke-prone rats by Shaughnessy KS1, Boswall IA, Scanlan AP, Gottschall-Pass KT, Sweeney MI.(PubMed)

(90) The incredible smoothie Green Tea, Coffee and Blueberry for reduced risk and treatment of Stroke by Kyle J. Norton

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Saturday, 30 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The top anti inflammatory Foods - Ginger

Friday, 29 April 2016

Most Common Disease of50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The top anti inflammatory Foods - Onion

Thursday, 28 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The top anti inflammatory Foods - Shiitake mushroom

Wednesday, 27 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The top anti inflammatory Foods - Green Tea

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The top anti inflammatory Foods - Turmeric

Tuesday, 26 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The top anti inflammatory Foods - Garlic

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The Do’s and Do not’s list

Monday, 25 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The Misdiagnosis and delay diagnosis

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The Diagnosis

Sunday, 24 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The Complication of Advanced gout

Saturday, 23 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The Complication of Recurrent gout

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The Complication of Joint damage

Thursday, 21 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The Complication of Kidney stone

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - Diseases associated with Gout - Psoriasis

Wednesday, 20 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The Complication of Tophi

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - Diseases associated with Gout - Peripheral vascular(artery) disease

Tuesday, 19 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - Diseases associated with Gout - Stroke