Papaya Extract and Fermented Papaya Process Anti Diabetes Activity in Vivo and Clinical Diagnosis

By Kyle J. Norton

Papaya may be the next potential target of pharmacological companies to identify the ingredients for the treatment of type 2 diabetes, some scientists suggested.

Diabetes is a chronic and low-grade inflammatory disease caused the insufficient insulin entering the bloodstream to neutralize the levels of glucose due to insulin resistance.

There are many causes that facilitate the insufficient levels of insulin produced by the body.

Some researchers suggested it is either caused by cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. and in some cases, insulin resistance is also caused by allergic reactions of cells in the immune system.


Is diabetes a low-grade inflammatory disease, Dr. Yansong ZHENG, in the answer to the above question said, " Chemicals from the fat cells could lead to inflammatory response and the levels of certain inflammatory chemicals are often higher in people with T2D compared to people without diabetes as well. Inflammatory responses contribute to the development of T2D and some even insinuated that T2D is actually inflammatory disease".


Moreover, in this review of the interconnection between obesity, inflammation, and insulin resistance and pro-inflammatory cytokines cause insulin resistance in adipose tissue, skeletal muscle, and liver by inhibiting insulin signal transduction., Dr. Carl de Luca, the lead author at the University of California, wrote, "The sources of cytokines in insulin-resistant states are the insulin target tissue themselves, primarily fat and liver, but to a larger extent the activated tissue-resident macrophages"


"While the initiating factors of this inflammatory response remain to be fully determined, chronic inflammation in these tissues could cause localized insulin resistance via autocrine/paracrine cytokine signaling and systemic insulin resistance via endocrine cytokine signaling all of which contribute to the abnormal metabolic state.

These results indicated a strong relationship between chronic low-grade inflammation and diabetes caused by the immune mistakenly targets the tissues of adipose tissue, skeletal muscle, and liver in the initiation of insulin resistance, the major cause of diabetes onset.


Papaya is a species of Carica Papaya, belongs to the family Caricaceae and native to the tropics of the Americas, and was first cultivated in Mexico and several centuries

Chemical constituents of papaya include
Alkaloids, Cardenolides, Anthraquinones, Saponins, Tannin, phenol, flavonoid, anthocyanin, Benzyl glucosinolate, benzyl isothiocyanate, 5-(Hydroxymethyl)-2-furancarboxaldehyde, 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one and 1,3-dihydroxy-2-propanone, etc.

In the reaffirming of the use of unripe pawpaw (Carica papaya Linn) fruit for the management or treatment of diabetes mellitus in folklore medicine.,researchers launched an investigation to examine the inhibitory effects of the aqueous extract of different parts of unripe pawpaw fruit on key enzymes linked to type 2 diabetes (α-amylase and α-glucosidase) and sodium nitroprusside (SNP)-induced lipid peroxidation in rat pancreas in vitro.


All the extracts from papaya exerted a strong effect in the inhibition of α-amylase (IC50=0.87-1.11 mg/mL), α-glucosidase (IC50=1.76-2.64 mg/mL) and SNP-induced lipid peroxidation (IC50=1.99-2.42 mg/mL) in a dose-dependent manner.

The combination of the flesh, seed, and peel in equal amounts had the highest inhibitory effect on α-amylase and α-glucosidase activities compared to extract-treated rats.

Dr.Oboh G, after taking into account co and confounders, said, "Strong inhibitory activities of the unripe pawpaw fruit against key enzymes linked to type 2 diabetes and SNP-induced lipid peroxidation in rat pancreas could be part of the mechanism by which unripe pawpaw is used in the management/prevention of diabetes mellitus in folk medicine".

Furthermore, in the study involving diabetes induced in rats by intraperitoneal administration of 60 mg/kg of streptozotocin (STZ) followed by the administered aqueous extract of C. papaya in three different doses (0.75, 1.5, and 3 g/100 mL) as drinking water to both diabetic and non-diabetic animals during 4 weeks.

After examining the blood samples collected from the treatment group compared to the non-diabetic group, the researcher found that
* The aqueous extract of Carica papaya (0.75 g and 1.5 g/100 mL) significantly decreased blood glucose levels (p<0.05) in diabetic rats.

* Low plasma insulin levels did not change after treatment in diabetic rats, but they significantly increased in non-diabetic animals.

* Pancreatic islet cells were normal in non-diabetic treated animals, whereas in diabetic treated rats, C. papaya could help islet regeneration manifested as the preservation of cell size.

* In the liver of diabetic treated rats, C. papaya prevented hepatocyte disruption, as well as accumulation of glycogen and lipids.

* An antioxidant effect of C. papaya extract was also detected in diabetic rats.

Dr. Juárez-Rojop IE, the lead authors said, "aqueous extract of C. papaya exerted a hypoglycemic and antioxidant effect; it also improved the lipid profile in diabetic rats. In addition, the leaf extract positively affected the integrity and function of both liver and pancreas"


These results suggested that the aqueous extract of Carica papaya exerts a significant inhibitory effect in diabetes rats through mechanisms involving many aspects.


A short-term study by the University of Mauritius, also found that supplementation of fermented papaya also exhibited the antihyperglycemic effect in the management of diabetes and for those at risk for cardiovascular disease, neurological disease, and other conditions worsened by overt inflammation and oxidative stress.

Taken all together, papaya may be considered a functional food for the prevention and adjunct therapy for the treatment of diabetes through its antihyperglycemic activity without inducing any adverse effects


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Inhibition of key enzymes linked to type 2 diabetes and sodium nitroprusside-induced lipid peroxidation in rat pancreas by water-extractable phytochemicals from unripe pawpaw fruit (Carica papaya). by Oboh G, Olabiyi AA, Akinyemi AJ, Ademiluyi AO. (PubMed)
(2) Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats by Juárez-Rojop IE1, Díaz-Zagoya JC, Ble-Castillo JL, Miranda-Osorio PH, Castell-Rodríguez AE, Tovilla-Zárate CA, Rodríguez-Hernández A, Aguilar-Mariscal H, Ramón-Frías T, Bermúdez-Ocaña DY. (PubMed)
(3) Relationship between Type 2 Diabetes and Inflammation Diseases: Cohort Study in Chinese Adults by Yansong ZHENG,1 Guilan ZHANG,2 Zhilai CHEN,1 and Qiang ZENG. (PMC)

Banana, the Tasty Fruit Is Found to Process Anti-Hypertension Property, According to Clinical Diagnosis

By Kyle J. Norton

Scientists may have found an inexpensive whole fruit for the prevention and treatment of hypertension with no side effects, some studies found.

Banana is the common name of a genus of tropical herbaceous plants. It can grow from 3 to 9 m and belongs to the family of the lily and the orchid.

Hypertension is a medical condition characterized by abnormally high blood pressure. one of the preventable risk factors of heart disease associated with the cluster of metabolic syndrome.

In other words, high blood pressure means raising the pressure in your heart. the condition can be acute or chronic.

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.

Chronic high blood pressure epidemiologically can damage the arteries and causes blood clots to form in the arteries, blocking the blood flow and contributing to the onset of cardiovascular and neuro diseases.

Although certain chronic conditions such as kidney disease are found to associate with chronic hypertension which can only be treated by addressing the usable condition, the syndrome in the Western world is mostly a result of unhealthy diet and obesity.

According to a joint study led by the Tecnológico de Monterrey, that examined the effects of Western and Modern Mexican dietary patterns and the incident hypertension in Mexican women, the comparison of participants who followed the diet loaded heavily with vegetables, fruits, and legumes and who follow the Western and Modern Mexican dietary patterns loaded heavily with processed meats, fast foods, and red meat; and finally the third component was loaded heavily with corn tortillas, hot peppers, and sodas suggested that

* The multivariable-adjusted odds of hypertension in the highest quartile of the W pattern were 24% higher than the odds for individuals in the lowest quartile.


* Women in the highest quartile of the MM pattern had 15% higher odds than women in the lowest quartile.

* And The Fruits & Vegetables (FV) pattern was not significantly associated with hypertension.


These results strongly indicated high blood pressure can be prevented by following a healthy diet with high fruits and vegetables, whole grain and low saturated and trans fat, red meat, and processed foods.

On finding a natural chemical compound or whole food for the prevention and treatment of hypertension, researchers evaluate the corosolic acid (CRA) antihypertensive activity, a constituent of banana leaves.

The experiment included Six-week-old male SHR-cp rats, an animal model of metabolic syndrome were fed a high-fat diet containing 0.072% CRA for 14 weeks.
Treatment with CRA lowered blood pressure, which was elevated in control animals, by 10% after 8 weeks, and serum-free fatty acids by 21% after 2 weeks.

Oxidative stress markers thiobarbituric acid-reactive substances and 8-hydroxydeoxyguanosine in the tested animal were also decreased by 27% and 59%, respectively, after 2 weeks.

Furthermore, CRA treatment also reduced the levels of myeloperoxidase markers, 3-nitrotyrosine, and 3-chlorotyrosine, by 38% and 39%, respectively, after 10 weeks, and decreased the levels of high sensitivity C-reactive protein, markers of inflammation, after 6 weeks.

The presence of a marker of inflammation is the indication of inflammation.

These results clearly suggested that CRA ameliorate hypertension, and oxidative stress caused by the inflammation in SHR-cp rats.

Dr. Yamaguchi Y, the lead scientist said, "CRA can be beneficial for preventing atherosclerosis-related diseases that are an increasing health care problem worldwide".


Moreover, In a human study to test the effect of banana on cold stress-induced hypertension, peak expiratory flow rate, and plasma ACE activity, researchers showed that

*Banana treatment reduced the systolic blood pressure (P < 0.005), diastolic blood pressure (P < 0.025), and mean arterial blood pressure (P < 0.005) during cold stress in healthy volunteers compared to controls.

* There were no significant changes in heart rate and peak expiratory flow rate but only a significant decrease in plasma angiotensin-converting enzyme activity after banana treatment.


Levels of plasma angiotensin-converting enzyme are high in patients with hypertension.

Dr. Sarkar C, the lead scientist said' "Banana decreased the rise of systolic blood pressure and diastolic blood pressure in healthy volunteers subjected to cold stress test without much effect on heart rate and peak expiratory flow rate".

Taken altogether, bananas may be considered a functional fruit for the prevention and treatment of hypertension with no side effects.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Corosolic acid prevents oxidative stress, inflammation, and hypertension in SHR/NDmcr-cp rats, a model of metabolic syndrome by Yamaguchi Y1, Yamada K, Yoshikawa N, Nakamura K, Haginaka J, Kunitomo M.(PubMed)
(2) Effect of banana on cold stress test & peak expiratory flow rate in healthy volunteers by Sarkar C1, Bairy KL, Rao NM, Udupa EG. (PubMed)
(3) Western and Modern Mexican dietary patterns are directly associated with incident hypertension in Mexican women: a prospective follow-up study by Adriana Monge,1,2 Martín Lajous,1,4 Eduardo Ortiz-Panozo,1 Beatriz L. Rodríguez,2,3José Juan Góngora,2 and Ruy López-Ridaura. (PMC)

Herbal Calendula May Process Anti Cancers Property, Scientists Find

Kyle J. Norton

Scientists may have found a herbal remedy for the prevention and treatment of cancer, according to the studies.

Cancer is the class of diseases associated with irregular cell growth in some specific tissues and organs due to the alternation of cell DNA.

Depending on the stage and specific types of cancer, some cancers do not cause any symptoms such as liver cancer.

However, at the later stage, the larger size of the tumor may suppress the nearby blood vessels and nerve cells, leading to localized bleeding and pain accompanied by the general symptoms shared by other types of cancer.

At this stage, cancer cells may also travel a distance away from the original site to infect other healthy tissues and organs through fields and blood circulation, leading to secondary metastasis.

There are some common factors shared by many types of cancer such as family and personal history, ethnicity, and gender, some researchers found that an unhealthy lifestyle is one of the major risks in the induction of the diseases.

Dr. Katzke, Verena A Ph.D., the lead scientist in the concern of lifestyle and cancer risk, wrote, "Lifestyle factors, such as smoking, alcohol consumption, obesity, diet, and physical inactivity, and also reproductive and hormonal factors are considered as causes of cancer and main targets for primary prevention".

And, " While smoking, which may be responsible for around 20% to 30% of all incident cancers, is clearly the strongest lifestyle-related risk factor overall, followed by alcohol consumption and obesity, the importance of specific factors for individual cancer types and subtypes varies greatly.".


In other words, by changing to a healthy lifestyle, the risk of cancers can be reduced substantially.

Calendula is also known as pot marigold, annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe.

The herb medicine has been used in herbal medicine as spasmolytic, spasmogenic, inflammatory effects and to treat abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.

Besides major chemical constituents of triterpenoids, flavonoids, coumarins, quinones, volatile oil, carotenoids, and amino acids, the herb also contains loliolide (calendin), calendulin, and n-paraffins.

Researchers on finding natural chemotherapy for the treatment of cancer investigated the cytotoxic anti-tumor and immunomodulatory activities and in vivo antitumor effect of Laser Activated Calendula Extract (LACE), a novel extract of the plant Calendula Officinalis (Asteraceae).

The tumor cell lines included in the study are derived from leukemias, melanomas, fibrosarcomas, and breast, prostate, cervix, lung, pancreas, and colorectal cancer.


The LACE extract showed a potent in vitro inhibition of tumor cell proliferation in a wide variety of human and murine tumor cell lines, ranged from 70 to 100%.
The cancer cell inhibition was attributed to the protein associated with a cell cycle arrest in G0/G1 phase and induced apoptosis.

Furthermore, the intraperitoneal injection or oral administration of LACE extract in nude mice inhibits in vivo tumor growth of Ando-2 melanoma cells and prolongs the survival day of the mice.

However, human peripheral blood lymphocyte (PBL) and NKL cell lines, lACE extract exerted an opposite effect.

These results suggested that LACE aqueous extract has 2 potential anti-tumor therapeutic effects: cytotoxic tumor cell activity and lymphocyte activation on selected cancer cell lines.

Moreover, in male mice injected with B16F-10 melanoma cells through the tail vein and simultaneously treated with C.officinalis flower extract. researcher showed that
* Simultaneous administration of C. officinalis extract to tumor-bearing C57BL/6 mice reduced the lung tumor nodules by 74% with a 43.3% increase in lifespan

* Elevated levels of inflammatory expression including the proinflammatory cytokines were found to be significantly lowered in the C. officinalis treated animals.


* The extract also inhibited the expression of the matrix and enzymes associated with cancer proliferation and activated the family protein associated with the modulation of cancer cell transcriptional profile.

Taken altogether, herbal Calendula may be considered a safe functional remedy for the prevention and combined with primary medicine for the treatment of cancers with no side effects, pending the confirmation of large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References(1) Screening the antiangiogenic activity of medicinal plants grown and sold in Jordan by Zihlif M1, Afifi F, Muhtaseb R, Al-Khatib S, Abaza I, Naffa R.(PubMed)
(2) A new extract of the plant Calendula officinalis produces a dual in vitro effect: cytotoxic anti-tumor activity and lymphocyte activation by Jiménez-Medina E1, Garcia-Lora A, Paco L, Algarra I, Collado A, Garrido F.(PubMed)
(3) Inhibition of metastasis of B16F-10 melanoma cells in C57BL/6 mice by an extract of Calendula officinalis L flowers by Preethi KC1, Siveen KS, Kuttan R, Kuttan G.(PubMed)
(4) Lifestyle and Cancer Risk by Katzke, Verena A Ph.D.; Kaaks, Rudolf Ph.D.; Kühn, Tilman Ph.D. (The Cancer Journal)

Herbal Cascara Sagrada May Process Anti Breast Cancer Activity, Researchers Say

By Kyle J. Norton

Herbal Cascara sagrada may be the next generation of natural chemotherapy for the treatment of breast cancer, according to studies.

Breast cancer is a medical and chronic condition characterized by cell growth irregularly due to the alternation of DNA.

Most cases of breast cancer start in the cells on the surface of the inner lining of the breast tissue, including the milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

At the advanced, the large tumor may press on the nearby blood vessels and nerve cells, leading to bleeding and severe pain. Cancer cells from the breast can also travel a distance away to infect other healthy tissue and organs at this stage.

The most common breast cancer secondary metastasis is the liver, brain, bones, or lungs.

According to the statistics, in 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during a lifetime of a woman is 1/8.

Researchers do not know the exact causes of breast cancer. However, family and personal history, women with dense breast tissue, use of hormone replacement therapy and oral contraceptives, genetic preposition, particularly BRCA1 and 2, tall adult heigh are some prevalent risk factors of the disease.

Some researchers suggested that the increase in the prevalence of breast cancer in overweight and obesity is also a major concern of the scientists' community.

Dr. Manuel Picon‐Ruiz, the lead scientists in the observation of obesity in the risk of breast cancer wrote, "Obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women, and with worse disease outcome for women of all ages" and "... the effects of obesity to increase local and circulating proinflammatory cytokines, promote tumor angiogenesis and stimulate the most malignant cancer stem cell population to drive cancer growth, invasion, and metastasis".

And, "The effects of recent lifestyle interventions to decrease sex steroids, insulin/insulin‐like growth factor‐1 pathway activation and inflammatory biomarkers associated with worse breast cancer outcomes in obesity also are discussed. Although many observational studies indicate that exercise with weight loss is associated with improved breast cancer outcome".

The results strongly suggested that the risk of breast cancer is significantly elevated in the obese population compared to healthy adults.

Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America, it's bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc.

The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C, and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.

Researchers on clarification of the effects of a bioactive ingredient emodin found abundantly in herbal Cascara Sagrada and Rhubarb. against breast cancer, examined the compound activity on estrogen receptor α (ERα).

The application of emodin demonstrated the capability in inhibiting breast cancer cell proliferation by suppressing the ER α protein levels, through blocking the ER α transcriptional activation.

Furthermore, emodin treatment led to the dissociation of heat shock protein 90 (HSP90) which plays a critical role in stabilizing the proteins against heat stress and ER α and increased ER α ubiquitination in initiation cell degradation.


Dr. Huang PH and colleagues in the final report wrote, "emodin,....specifically suppress breast cancer cell proliferation by targeting ER α protein stability through distinct mechanisms".


In order to reveal the additional information of emodin in the inhibition of breast cancer, researchers investigated the anticancer effects of emodin on growth inhibition, apoptosis induction, and the expression of apoptosis-related genes in MCF-7 cells.


Emodin showed significant growth inhibitory effects on MCF-7 cells with IC₅₀ = 7.22 µg/ml (∼30 μM) and exerted a concentration-dependent inhibitory effect on the colony-forming ability of MCF-7 cells with IC₅₀ = 7.60 µg/ml (∼30 µM).

The bioactive compound induced breast cancer death observed by the single-strand DNA breakage and DNA fragmentation, in emodin-treated MCF-7 cells.

Moreover, emodin efficacy in causing breast cancer cells apoptosis was attributed to the activation of the gene expression involved the modulation of the immune response to stress and inhibition of the proteins associated with cancer cell proliferation and survival.


Dr. Li WY, the lead scientist after taking into account co and confounders said, "emodin could induce growth inhibition and apoptosis in MCF-7 cells through the modulation of the expression of apoptosis-related genes".

Taken altogether, herbal Cascara Sagrada (Rhamnus purshiana) processed bioactive emodin may be considered a functional remedy for the prevention and combined with primary therapy for the treatment of breast cancer, pending the confirmation of a large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Emodin and Aloe-Emodin Suppress Breast Cancer Cell Proliferation through ER α Inhibition, by Huang PH, Huang CY, Chen MC, Lee YT, Yue CH, Wang HY, Lin H.(PubMed)
(2) Synergistic effects of curcumin with emodin against the proliferation and invasion of breast cancer cells through upregulation of miR-34a. by Guo J, Li W, Shi H, Xie X, Li L, Tang H, Wu M, Kong Y, Yang L, Gao J, Liu P, Wei W, Xie X.(PubMed)
(3) Emodin induces cytotoxic effect in human breast carcinoma MCF-7 cell through modulating the expression of apoptosis-related genes by Li WY, Chan RY, Yu PH, Chan SW. (PubMed)
(4) Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention by Manuel Picon‐Ruiz, Ph.D., 1 Cynthia Morata‐Tarifa, Ph.D., 2 Janeiro J. Valle‐Goffin, MD, 3Eitan R. Friedman, MD, 4 and Joyce M. Slingerland, MD, Ph.D. (PMC)

Will Acadia Honey Be Used to Replace Prednisolone for Acute and Chronic Pain Relief?

By Kyle J. Norton

Antinociception is the process that blocks sensory neuron response to potentially damaging stimuli associated with pain.

Pain is a natural reaction with an aim to protect our body against danger or damage.

Acute pain is the pain that lasts less few weeks.

Chronic pain is pain that lasts more than 6 months.

Chronic pain has been found to be the most common reason for someone to see his/her physician.

Chronic pain in some cases was a major symptom of a medical condition that can only be treated physically and mentally through pain management.

However, most cases of chronic pain are associated with injury, such as a back sprain, or there may be an ongoing cause, such as illness.

Chronic pain can interfere with a person's quality of life and general functioning.

According to statistics provided by Dr. Donald Schopflocher, lead scientists in the evaluation of the prevalence of chronic pain in Canada, researchers wrote, "The prevalence of chronic pain for adults older than 18 years of age was 18.9%".

And, "Chronic pain prevalence was greater in older adults, and females had a higher prevalence at older ages compared with males. Approximately one-half of those with chronic pain reported suffering for more than 10 years. Approximately one-third of those reporting chronic pain rated the intensity in the very severe range".

Chronic pain according to the study is very common, affecting approximately 19% of Canadian over 18 years of age, mostly in older adults.

Honey, the rich golden liquid is a miraculous product made by bees using nectar from flowers.

The liquid is considered one of the healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

Researchers on finding a potential natural whole food for pain relief examined the Tualang honey (Fēng Mì) and prednisolone on the nociceptive response in male Sprague-Dawley rats.

35 male Sprague-Dawley rats selected for the study were divided into 5 groups. Each group was given either distilled water, Tualang honey (0.2, 1.2 or 2.4 g/kg), or prednisolone (10 mg/kg) for 10 days.

Where prednisolone is a steroid medication used for pain relief.

According to the response to a noxious thermal stimulus using the tail-flick test on Day 10, the tail-flick latency time was significantly higher in the groups that received 1.2 g/kg and 2.4 g/kg of Tualang honey and 10 mg/kg of prednisolone, compared to the control group.

Compared to the groups treated with prednisolone or distilled water, Tualuang honey treatments showed no effects on other parameters.

In other words, the Tualang honey treatment group showed signs of abnormal behavior, such as total food pellet intake or weight loss.

Dr. Aziz CB, the lead scientist at the Universiti Sains Malaysia, said, "preemptive administration of Tualang honey (1.2 g/kg and 2.4 g/kg) and prednisolone (10 mg/kg) had reduced the pain responses".

Based on these results, Tualang honey processes a strong antinociceptive better than those of corticosteroids (prednisolone).

In order to reveal more information about the honey antinociceptive activity, researchers compared several kinds of honey pain relief efficacy.

Acacia honey showed the most effective dose-dependent antinociceptive activity compared to the untreated group in tail-flick and paw-withdrawal tests, respectively.

Most tested honeys exerted antinociceptive activity of reaching the maximum at 60 min post-treatment then gradually decreased, whereas the activity of indomethacin was persistent at 120 min post-treatment.

Interestingly, the major constituents found in honey such as fructose, glucose, maltose, and sucrose used alone do not demonstrate any effect compared to the whole food.

The results strongly suggested that there must be other compounds in the honey that process a significant antinociceptive property or all active ingredients in honey work together to stimulate the pain relief activity.


Taken altogether, honey, particularly, Tualang and Acacia honey may be considered a functional remedy for acute and chronic pain relief, pending the confirmation of large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) The antinociceptive effects of tualang honey in male sprague-dawley rats: a preliminary study by Aziz CB1, Ismail CA1, Hussin CM2, Mohamed M. (PubMed)
(2) Antinociceptive activity of natural honey in thermal-nociception models in mice by Azim MK1, Perveen H, Mesaik MA, Simjee SU. (PubMed)
(3) The prevalence of chronic pain in Canada by Donald Schopflocher, PhD,1,2 Paul Taenzer, PhD,3 and Roman Jovey, MD. (PubMed)

Bilberry Maybe Effective Against Intestinal Cancer with No Side Effects, Scientists Say

By Kyle J. Norton

Intestinal cancer is a medical condition characterized by irregular cell growth in the tissue of the intestines.

Most cases of intestinal cancer start in the cells on the surface of the inner lining of the internal tissue. At the advanced stage, after penetrating deep layers of the intestines, the cancer cells can travel a distance away from the intestine to infect other healthy tissue and organs, leading to secondary metastasis.

Certain factors such as being overweight or obese, physical inactivity, certain types of diet. smoking excessive alcohol drinking, family and personal history, and the increase in age are associated with an increased risk of intestinal cancer.

Some researchers suggested that the increased incidence of intestinal cancer in the Western world may be associated with the promotion of a high-fat Western diet over the past many decades.

Dr. Manon D. Schulz, the lead scientist in the investigation of the effects of high-fat diet-mediated dysbiosis promotes intestinal carcinogenesis suggested, "Several aspects common to a Western lifestyle, including obesity and decreased physical activity, are known risks for gastrointestinal cancers. There is substantial evidence suggesting that diet profoundly affects the composition of the intestinal microbiota. Moreover, there is now unequivocal evidence linking dysbiosis to cancer development".

And, "Undoubtedly various factors contribute to the etiology of intestinal cancer, but there are compelling arguments to include high-fat diet (HFD) and composition of the gut microbiota as key risk factors".

The results strongly suggested that the risk of intestinal cancer can be decreased by changing the diet pattern from the Western diet to a traditional diet with higher fruits and vegetables with a lower intake of red meat and saturated and trans fat and processed foods.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.


The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Researchers on finding a natural compound for the treatment of intestinal carcinogenesis examined the
intestinal carcinogenesis--relationship with tissue anthocyanin levels in an animal model.

Selected Apc(Min) mice ingested C3G or Mirtoselect at 0.03, 0.1, or 0.3% in the diet for 12 weeks, and intestinal adenomas were examined.


Where Mirtoselect, is an anthocyanin mixture from bilberry, and isolated cyanidin-3-glucoside (C3G) is the most abundant anthocyanin in the diet.

C3G and Mirtoselect at the highest doses decreased the adenoma numbers by 45% (p < 0.001) or 30% (p < 0.05), respectively, compared to controls.

According to the intestinal mucosa and urinary assays, anthocyanins were found at the analytical detection limit in the plasma and at quantifiable levels.

More precisely, the total anthocyanin levels in mice on C3G or Mirtoselect were 43 ng and 8.1 microg/g tissue, respectively, in the intestinal mucosa, and 7.2 and 12.3 microg/ml in the urine.
These results suggested that C3G and Mirtoselect in the Apc(Min) mouse processed a chemotherapeutic effect for the treatment of intestinal carcinogenesis.


Moreover, in order to reveal more information about berries anti intestinal tumorigenesis, researchers examined the different phenolic profiles on intestinal tumorigenesis in multiple intestinal neoplasia/+ mice.

Mice selected for the study were fed a high-fat AIN93-G diet (Con) or AIN93-G diets containing 10% (w:w) freeze-dried bilberry, lingonberry (LB), or cloudberry (CB) for 10 wk.

All 3 berries significantly inhibited the formation of intestinal adenomas as indicated by a 15-30% reduction in tumor numbers.

According to Western blotting and immunohistochemistry, all 3 berries inhibited the levels of decreased levels of proteins associated with cell cycle division.


Additionally, all 3 berries exerted early protection of the cells in the intestine against the alternation of cell DNA to facilitate the onset of the disease.


The findings strongly suggested the use of berries as chemopreventive components for the treatment of intestinal carcinogenesis.


Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of
intestinal cancer, pending the confirmation of large sample size and multicenter study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Effect of cyanidin-3-glucoside and an anthocyanin mixture from bilberry on adenoma development in the ApcMin mouse model of intestinal carcinogenesis--relationship with tissue anthocyanin levels by Cooke D1, Schwarz M, Boocock D, Winterhalter P, Steward WP, Gescher AJ, Marczylo TH. (PubMed)
(2) Three Nordic berries inhibit intestinal tumorigenesis in multiple intestinalneoplasia/+ mice by modulating beta-catenin signaling in the tumor and transcription in the mucosa by Misikangas M1, Pajari AM, Päivärinta E, Oikarinen SI, Rajakangas J, Marttinen M, Takayama H, Törrönen R, Mutanen M. (PubMed)
(3) High-fat diet-mediated dysbiosis promotes intestinal carcinogenesis independent of obesity by Manon D. Schulz,1,* Çigdem Atay,1,* Jessica Heringer,1,* Franziska K. Romrig,1Sarah Schwitalla,1 Begüm Aydin,2 Paul K. Ziegler,3,4,5 Julia Varga,3,4,5 Wolfgang Reindl,6Claudia Pommerenke,7 Gabriela Salinas-Riester,7 Andreas Böck,8 Carl Alpert,9 Michael Blaut,9Sara C. Polson,10 Lydia Brandl,11 Thomas Kirchner,11 Florian R. Greten,3,4,5Shawn W. Polson,10 and Melek C. Arkan. (PMC)

Herbal Angelica Processes Anti- Cancer Activity in Vitro

By Kyle J. Norton

Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.

Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.

The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Lung, breast, prostate, and colorectal cancers are the most common cancer in the US.

Free radicals are unstable atoms with a single electron in the outer ring. Therefore, in order to remain stable. free radicals are ready to donate or intercept an electron from other atoms, leading to a chain of oxidative reactions that can not be stopped until all electrons are paired or inhibited by antioxidants.

Oxidative stress is an imbalanced ratio of free radicals and antioxidants in the body. It is caused by either overexpression of free radicals or depletion of antioxidants in the body.

Believe it or not. overexpression of free radicals for a long period of time or oxidative stress can cause cells and lipid damage, leading to alteration of cell DNA, a leading cause of cancer.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a natural compound for the treatment of diseases associated with DNA alternation, the researchers examined the effects of Angelica n-Butylidenephthalide (BP) anti-cancer activity.

According to the assays that the results from the application of riboflavin-5'-phosphate (RFMP) immobilized iron oxide magnetic nanoparticles (Fe3O4 MNPs) as carriers for BP to treat cancer cell lines overexpressed riboflavin receptors on their cell membrane-derived from liver, prostate, breast, cancer cells
* BP treatment. showed a strong sensitivity to the tested cell lines.

* BP-binding free riboflavin-5'-phosphate (RFMP) on MNPs to target these model cells during the period of treatment by readily released on target cancer cells.

* Fe3O4@RFMP MNPs immobilized with BP released free-form BP at a similar amount for the inhibition of cancer cells, with no apparent harmful effects on non-target cells.

* BP-Fe3O4@RFMP MNPs upregulated the level of cysteine-aspartic acid protease 3 (caspase 3) associated with cancer cell apoptosis.

Taken altogether, Herbal Angelica may be sued for the treatment of cancer, pending to larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Riboflavin immobilized Fe3O4 magnetic nanoparticles carried with n-butylidenephthalide as targeting-based anticancer agents by Wu CY1, Chen YC. (PubMed)

Betanin Isolated From Beetroot, a Potential and Natural Plant-Based Antioxidant that Prevents Oxidative Stress Developing

By Kyle J. Norton

Oxidative stress is a condition caused by an imbalance of the ratio of free radicals and antioxidants in the body.

In other words, oxidative stress is either caused by overexpression of free radicals or depletion of antioxidant enzymes in the body.

Some researchers suggested that oxidative stress may also arise due to the chain reaction of free radicals in which free radicals donate or intercept an electron from other stable molecules.

Long-term oxidative stress present in the body can cause protein and lipid damage and alternation of cell DNA, leading to the onset of chronic diseases, including cardiovascular disease, diabetes, and cancer.

More precisely, exogenous factors, such as cigarette smoke, and endogenous factors, such as the oxidative burst from activated macrophages are some of the factors involved in the risk of oxidative stress.

The Liver Pathophysiology, 2017 in the explanation of the cause of oxidative stress, wrote, " (1) the presence of xenobiotics, (2) the activation of the immune system in response to invading microorganisms (inflammation), and (3) radiation, which makes oxidative stress a common denominator of toxicity or stress".

In other words, oxidative stress may be preventable by following a diet rich in antioxidants such as a diet with higher fruits and vegetable consumption accompanied by moderate exercise and reducing intake of saturated and trans fat and processed foods.

Betanin is a phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to find a potential compound for the prevention of diseases associated with oxidative stress, researchers examined the effects of natural pigment betanin on oxidative stress in the kidney of paraquat-treated rats.

Paraquat injected intraperitoneally induce renal damage rats were randomly divided into four groups: a control group, a paraquat group, and two paraquat groups that were treated with betanin at 25 and 100 mg/kg/d three days before and two days after paraquat administration.

Betanin-treated rats showed strong activity in alleviating the paraquat-incurred acute kidney injury, observed by the improvement, reduced serum and urine markers that indicate a kidney injury.

Betanin also decreased oxidative stress elicited by paraquat by increasing the expression of antioxidant enzymes produced by the host accompanied by inhibiting the levels of free radicals.

These results suggested that betanin protects the tested rats against kidney damage due to oxidative stress in the induction of chronic inflammation.

In streptozotocin (STZ) induced diabetes (DN) in rats, researchers examined the betanin anti-fibrotic mechanisms in rat kidneys.

Betanin at a dose of 25, 50, and 100mg/kg/day and lisinopril (5mg/kg/day, reference compound) orally administered for 8 weeks after the induction of DN, not only significantly inhibited proteinuria, blood glucose, serum creatinine and blood urea nitrogen (BUN) levels involved in kidney injury, but also restored antioxidant enzyme activities in kidney tissue.

Additionally, betanin treatment also protected kidney integrity by reducing the glomerular surface area, glomerulosclerosis, and tubulointerstitial fibrosis.

In other words, betanin demonstrated the kidney protective activity against streptozotocin (STZ) induced diabetes (DN) in rats through regulation of transforming growth factor-beta (TGF-β) in facilitating the anti-oxidative and anti-inflammatory activity.


Taken altogether, betanin may be considered supplements for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of a larger sample size and multicenter human study.

Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Betanin attenuates oxidative stress and inflammatory reaction in the kidney of a paraquat-treated rat by Tan D1, Wang Y2, Bai B1, Yang X2, Han J. (PubMed)
(2) Betanin, isolated from fruits of Opuntia elatior Mill attenuates renal fibrosis in diabetic rats through regulating oxidative stress and TGF-β pathway by Sutariya B1, Saraf M2. (PubMed)
(3) Oxidative Stress, From Liver Pathophysiology, 2017. (Science Direct)

Phytochemical 3,3'-Diindolylmethane Isolated From Cruciferous Vegetables Inhibit Parameters Associated with the Risk of Hyperglycemia

By Kyle J. Norton

Hyperglycemia is a condition of abnormally high blood sugar in the bloodstream associated with diabetic complications in patients with type 2 diabetes.

In order words, hyperglycemia is a result of the body which isn't properly using or doesn't make the hormone insulin.

Hyperglycemia is also considered a hallmark of patients with type 2 diabetes. Another hallmark is insulin resistance.

The condition occurs mostly due to poor control and management in patients with diabetes such as
a poor diet, physical inactivity choices, symptoms of medicines intake.


Some patients with diabetes also experience symptoms of hyperglycemia due to skipping or not taking enough glucose-lowering medication.


The most common symptoms of hyperglycemia are frequent urination, increased thirst, blurred vision, persistent fatigue, and headache.

If you are having some of the aforementioned symptoms, you may have hyperglycemia. Please make sure you check with your doctor to prevent longer-term untreated complications.

According to epidemiological studies, untreated or long-term persistently hyperglycemia in patients with diabetes has been found to induce serious symptoms such as shortness of breath, confusion, and coma.

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

With an aim to find a natural ingredient for the treatment of hyperglycemia in patients with type 2 diabetes, researchers examined the effect of the nutritive phytochemicals, indole-3-carbinol (I3C) and its metabolite, 3, 3'- diindolylmethane (DIM) on oxidative stress developed in type 2 diabetes mellitus (T2DM).

The study is carried out on the genetically modified mouse (C57BL/6J mice) similar to those of metabolic abnormalities of the human disease after the administration of a high-fat diet (HFD).

Injection of DIM and I3C positively modulated the glucose, insulin, and hemoglobin (Hb), glycated hemoglobin (HbA1c) level, an indication of the hyperglycemically modulatory activities in the tested HFD mice.

Compared to the HFD group, treatment groups showed a decrease in the levels of thiobarbituric acid reactive substances (TBARS), lipid hydroperoxides (LOOH), conjugated dienes (CD associated with oxidative stress in lipid peroxidation.

Furthermore, DIM and I3C also improved the antioxidant enzymes produced by the host observed by the increasing SOD, CAT, GPx levels in the erythrocyte, liver, kidney, and heart.

Levels of free radical scavengers such as vitamin C, vitamin E, and GSH levels are also increased in the plasma, liver, kidney, and heart in diabetic mice.

In other words, DIM and I3C protected diabetic mice against diabetics complications by modulating blood glucose and lipid by balancing the ratio of free radicals and antioxidants in the tested subjects.

Based on the finding, researchers wrote in the final report, "the antioxidant-scavenging action was accelerated in mice treated with DIM than the I3C treatment group which was comparable with the standard drug metformin".

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of hyperglycemia, pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Attenuation of hyperglycemia-mediated oxidative stress by indole-3-carbinol and its metabolite 3, 3'- diindolylmethane in C57BL/6J mice by Jayakumar P1, Pugalendi KV, Sankaran M. (PubMed)

Plant-Based Alliin Isolated From Garlic and Onion May Process Anti Liver Cancer Property, Researchers Say

By Kyle J. Norton

Liver cancer is a medical condition caused by irregular cell growth in the liver tissue.

According to the statistics assessed by the cancer experts, in 2019, approximately 42,030 adults (29,480 men and 12,550 women) in the United States will be diagnosed with primary liver cancer.

Believe it or not, since 1980, the incidence of liver cancer has tripled. Between 2006 and 2015, the number of people diagnosed with the disease increased by approximately 3% annually.

The most common preventable causes of liver cancer are excessive alcohol drinking over time, chronic infection by hepatitis B and C, and cirrhosis.

Types of liver cancer include

* Hepatocellular carcinoma, the most common type of liver cancer accounting for 75 percent of all cases.

* Cholangiocarcinoma is a cancer of the bile duct, which is the small, tube-like bile ducts in the liver that carry bile to the gallbladder to help with digestion.


* Liver Angiosarcoma is a rare form of liver cancer that develops quickly and

* Hepatoblastoma also is a rare type of liver cancer found in children, particularly in those under age 3.


The most common symptoms of liver cancer are upper abdominal pain., abdominal swelling, jaundice and white, chalky stools, accompanied by general symptoms shared by other types of cancer including unintended weight loss, gastrointestinal discomfort, loss of appetite, and persistent fatigue.

If you have experienced some of the aforementioned symptoms with no signs of receding, please make sure that you check with your doctor to rule out the possibility.

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

With an aim to find a potential ingredient for the treatment of liver cancer with little or no side effects, researchers in the cancer team at the Institut National de la Recherche Agronomique examined the increasing fertilization of soil resulted in an increased alliin content of the powders on liver cancer animal model.

According to the results, garlic powders administered to rats for 2 weeks (5% of the diet), administration of the different garlic powders demonstrated a 35-60% reduction in DNA damage induced by N-nitrosodimethylamine (NDMA) in rat liver.

In examining the increased alliin content of the garlic powder, researchers found that the presence of alliin was associated strongly with a proportional decrease in NDMA induced DNA alteration.


Believe it or not, the increased levels of Alliin in the garlic powder content did not have an additional effect on DNA damage induced by aflatoxin B1 in the liver or by 1,2-dimethylhydrazine in the colon, compared to the efficacy in the liver.

In other words, garlic powders regardless of the levels of alliin did not modify the genotoxic activity which is the direct-acting carcinogen methyl nitrosourea in the colon.

Taken altogether, alliin may be considered a supplement for the prevention and treatment of liver cancer, depending on the confirmation of the larger sample size and multicenter human study.



Intake of alliin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibition of carcinogen-induced DNA damage in rat liver and colon by garlic powders with varying alliin content by Singh V1, Belloir C, Siess MH, Le Bon AM. (PubMed)
(2) Effects of garlic powders with varying alliin contents on hepatic drug metabolizing enzymes in rats by Le Bon AM1, Vernevaut MF, Guenot L, Kahane R, Auger J, Arnault I, Haffner T, Siess MH.(PubMed)

Onion's Quercetin Inhibits Invasive Osteosarcoma in Vitro, According to Study

By Kyle J. Norton

Osteosarcoma is a type of bone cancer found mostly in teenagers and people over age 60.

Most cases of osteosarcoma are associated with genetic syndromes. In other words, Osteosarcoma is associated with a genetic preposition inherited from the parent.

Dr. James J. Morrow wrote, "Osteosarcoma is the most common primary malignancy of bone, typically presenting in the first or second decade of life".

And, " Increased risk of osteosarcoma is associated with a number of well-defined genetic syndromes: hereditary retinoblastoma (germline mutation of the Rb gene), Li-Fraumeni syndrome (germline mutation of the p53 gene), Bloom syndrome (germline mutation of the RECQL2 gene), Werner syndrome (germline mutation of the RECQL3 gene), and Rothmund-Thomson syndrome (germline mutation of the RECQL4 gene)".

The exact causes of osteosarcoma are unidentified. However, epidemiologically, besides gene expression, an unhealthy lifestyle such as body weight, physical activity, diet, and tobacco, gender, age, height, ethnicity, and exposure to bone radiation are also some prevalent factors found in patients with the disease.

According to the statistic, in the US, osteosarcoma is rare and approximately 900 new cases of osteosarcoma are diagnosed each year. Children and teens are younger than 20 accounts for half of the numbers.

The overall 5-year survival rate for children and teens with osteosarcoma is 70%. If cancer has spread to the lung, the 5-year survival rate is only 40% comapred to localized cancer between 60% to 80%.


Conventionally, Most cases of osteosarcoma are o treated with a combination of surgery, chemotherapy, and radiation therapy.


In patients with high-grade tumors, before surgery, neo-adjuvant therapy may be necessary to shrink the tumor.

The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.

On finding a potent ingredient for the treatment of osteosarcoma researchers examined the effects of quercetin on proliferation, migration, and invasion in U2OS and Saos-2 cells.

According to the tested analysis, quercetin (20, 40, 60, 80, or 100 μM) for 48 h, incubation with U2OS and Saos-2 cells showed a significant reduction of cancer cell viability, in a dose-dependent manner.

Cell adhesion, invasion, and migration of the tested cell lines were also significantly inhibited by the application of quercetin only at higher concentrations.

Furthermore, the expressions of pro-apoptotic matrixes were increased accompanied by the decrease of anti-apoptotic proteins.

Moreover, gene PTHR1 associated with tumor proliferation was also decreased by quercetin.

More precisely, PTHR1 expression in U2OS cells was reduced by 0.18-, and 0.41-fold at 80, and 100 μM, respectively, whereas 0.15 and 0.38 folds in Saos-2 cells.

In other words, by inhibiting the expression of PTHR, quercetin inhibited proliferation and invasion of the tested cell lines.

Based on the results, researchers said, "quercetin reduced human metastatic osteosarcoma cell invasion, adhesion, proliferation, and migration by inhibiting PTHR1."

Taken altogether, onion may be considered a remedy for the prevention and treatment of metastatic osteosarcoma, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Quercetin suppresses the proliferation and metastasis of metastatic osteosarcoma cells by inhibiting parathyroid hormone receptor 1 by Li S1, Pei Y1, Wang W1, Liu F1, Zheng K2, Zhang X.
(PubMed)
(2) Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-κB and matrix metalloproteinase-2/-9 signaling pathways by Lai WW1, Hsu SC, Chueh FS, Chen YY, Yang JS, Lin JP, Lien JC, Tsai CH, Chung JG. (PubMed)

Cucumber's Cucurbitacin B (CuB) Modulates the Capacity of Gut Microbiota in Vitro and Vivo

By Kyle J. Norton

Gut Microbiota is a community of microorganisms living in our gut. Under normal conditions, the ratio of the gut microbiome composition is balanced.

However, the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle may alternate the ratio by increasing the growth of "bad" bacterias, leading to the development of chronic diseases such as inflammatory bowel disease, obesity, cancer, and autism.

In other words, imbalanced of the gut microbiota may have a strong and negative impact on the immunity, the digestive, fat, and carbohydrate metabolism, and the central nervous system

* In immunity, the balance of the gut microbes showed to stimulate the immune function against inflammatory immune disorders.

* In the digestive system, balanced gut microbes protect the gut against gastrointestinal diseases and non-gastrointestinal diseases. caused by overexpression of bad bacteria.


* In carbohydrate metabolism, gut microbes influence the nutrient extraction from the diet, thus reducing the risk of obesity and obesity complications.

* Neurologically, gut microbiota can control brain insulin signaling and metabolite levels that play a critical role in neurobehaviors.

Out of many prevalent factors that cause the onset of the unbalanced ratio of gut microbiota, some researchers suggested that the Western diet may have negatively influenced to induce overgrowth of bad microorganisms in the gut.

Dr. Marit K. Zinöcker, the lead scientist wrote, "Western diet promotes inflammation that arises from both structural and behavioral changes in the resident microbiome"

And, "The environment created in the gut by ultra-processed foods, a hallmark of the Western diet, is an evolutionarily unique selection ground for microbes that can promote diverse forms of inflammatory disease".


The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to find a natural compound that enhances the gut microbiome's composition, researchers compared the effects of carrot, cucumber, and broccoli seed flours extracts with 50% acetone on gut microbiota modulating capacity.

In vitro, all three seed flour extracts enhanced the total number of gut bacteria and altered the abundance of specific bacterial phylum or genus.

In other words, cucumber showed a potential effect to improve the ratio of gut microbiota in the flavor of the "good" bacterias, similar to those of carrot and broccoli.


In J774A.1 cells, cucumber also exerted a similar activity by protecting the microbiota that exhibits anti-inflammatory activity by suppressing LPS induced production of pro-inflammatory cytokines, such as IL-1β and COX-2 mRNA expressions.

Furthermore, in obesity, induced progression of metabolic disorders, especially type 2 diabetes (T2DM), cucumber not only improved IR in obese mice and relieving inflammation in adipose tissue and blood but also enhanced the microbiota composition ratios.

More precisely, cucumber improved the ratio of gut microbiome composition by promoting IR and reducing inflammation.


Taken altogether, cucumber may be used for the improvement of gut microbiota, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Chemical Compositions of Cold-Pressed Broccoli, Carrot, and Cucumber Seed Flours and Their in Vitro Gut Microbiota Modulatory, Anti-inflammatory, and Free Radical Scavenging Properties by Choe U1, Li Y1,2, Gao B2, Yu L1, Wang TTY, Sun J, Chen P, Liu J3, Yu L. (PubMed)
(2) Therapeutic Effect of Cucumis melo L. Extract on Insulin Resistance and the gut microbiome in Lepob/Lepob Mice by Lee D1, Yoo JH1, Lee BC. (PubMed)
(3) The Western Diet–Microbiome-Host Interaction and Its Role in Metabolic Disease by Marit K. Zinöcker1, and Inge A. Lindseth. (PMC)

Cranberry Processes Immune-Modulatory Activity

By Kyle J. Norton

The immune system is the set of cells and their activity against antigens or infectious agents that comprise the body's defense system against diseases.

The immune system does a great job of keeping people healthy and preventing infections. Besides foods and nutritional supplements, herbs also play an important role in helping the immune system defend against viruses and bacteria attacks.

Active immunity may also be artificially acquired caused by the injection of the vaccine, a substance that contains antigen and passive immunity is an auto-response of the immune system against infection through the production of antigen.

Immunity can also be passive and active, Dr. David Baxter, in the article of "Active and passive immunity, vaccine types, excipients and licensing" wrote, "Active immunity refers to the process of exposing the body to an antigen to generate an adaptive immune response: the response takes days/weeks to develop but may be long-lasting—even lifelong" and " Passive immunity refers to the process of providing IgG antibodies to protect against infection; it gives immediate, but short-lived protection—several weeks to 3 or 4 months at most. Passive immunity is usually classified as natural or acquired".

However, an abnormal immune response such as overactive and underactive may cause a weakened immune system or autoimmune diseases.

Immunomodulatory activity is an action that improves the underactive immune function that is susceptible to the invasion of the foreign microorganism and inhibits the overactive immune system that causes autoimmune diseases.

In other words, the immunomodulatory activity is to modulate the genes involved in immune reactions, or of the neurohormonal system which regulates immune functions and any toxic or immunotoxic effects such as allergic reactions or destruction of immune effectors, that may cause harm to the body or interfere with the body normal function.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of diseases associated with immune compromise, researchers investigated the immunomodulatory effect of KC-1317 (a symbiotic mixture containing Saccharomyces boulardii lysate in a cranberry, colostrum-derived lactoferrin, fragaria,

The human trial included healthy volunteers with years of age ranging from 65-79 years with low natural killer (NK) cell activity,

According to the differentiation, liquid C-1317 showed a strong improvement in NK cell activity.

In other words, the select remedy resulted in immune-modulatory effects on the treatment group, compared to placebo at the end of 2 months.

Based on the findings, researchers said, " Although preliminary, these beneficial immune-modulatory effects of KC-1317 in aged individuals might indicate its employment within a wider age-management strategy".

Taken altogether, cranberry combined with other herbal medicine may be considered immune-modulatory remedy, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Gut-targeted immunonutrition boosting natural killer cell activity using Saccharomyces boulardii lysates in immuno-compromised healthy elderly subjects by Naito Y1, Marotta F, Kantah MK, Zerbinati N, Kushugulova A, Zhumadilov Z, Illuzzi N, Sapienza C, Takadanohara H, Kobayashi R, Catanzaro R. (PubMed)
(2) Active and passive immunity, vaccine types, excipients and licensing by David Baxter(Oxford Academic)

Fresh Cabbages, the Natural Antioxidants

By Kyle J. Norton

The expression of oxidative stress is a medical condition characterized by the imbalance of the ratio of free radicals and antioxidant enzymes produced by the host tissue.
by
In some cases, this reaction also is caused by a long-term accumulation of toxic substances in the body, such as lead, cadmium, mercury, and arsenic.

There is no single cause of oxidative stress. The onset of oxidative stress may include cigarette smoke, oxidative burst from activated macrophages, particularly, the free radicals chain reaction.

Sadly, a prolonged period of oxidative stress presented in the human body can cause oxidative damage to biomolecules, (lipids, proteins, DNA) and the death of healthy cells through cytotoxicity.

Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.

Due to its nature to become stable, free radicals readily to donate or steal an electron from other molecules, leading to the chain of domino's effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.

Overexpression of free radicals is known to cause damage in contributing to the etiology of many chronic health problems such as cardiovascular and inflammatory disease, cataracts, and cancer.

Antioxidants are stable atom that plays a critical role in protecting the body against the attack of free radicals.

In other words, antioxidants inhibited the onset of free radicals before they can cause a chain reaction in facilitating protein, lipid, and cell damage.

Antioxidants can either be produced by the liver or intake from dietary sources. Under normal conditions, antioxidant enzymes produced by the body in a healthy individual are good enough to counter the bombardment of free radical attacks.

Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem of which is crowded a mass of leaves, usually green but in some varieties, it may be red or purplish.

With an aim to find a natural food for the prevention of oxidative stress in the progression of cardiac diseases, researchers examined the effect of red cabbage fermentation on anthocyanin bioavailability and plasma antioxidant capacity in humans.

According to the results of the randomized crossover study of 13 volunteers who consumed fresh and fermented red cabbage, red cabbage products contained antioxidants of 20 different nonacylated and acylated anthocyanins with the main structure of cyanidin triglucosides.

Furthermore, the bioavailability of anthocyanin from fresh red cabbage was over 10% higher than from fermented red cabbage.

Moreover, fresh cabbage consumption induced a higher antioxidant capacity in volunteer plasma than that of fermented cabbage intake.

In other words, fresh cabbage processes a higher antioxidant capacity compared to fermentation.

Collectively, researchers said, "The study has shown that fermentation process affects red cabbage anthocyanins bioavailability and human plasma antioxidant capacity".

Taken altogether, cabbage processed abundantly phytochemicals may be considered a remedy for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.

Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The impact of red cabbage fermentation on bioavailability of anthocyanins and antioxidant capacity of human plasma by Wiczkowski W1, Szawara-Nowak D2, Romaszko J. (PubMed).

NHE-06 (Dandelion + 5 Other Herbal Medicines) Formula Kills Liver Cancer Cells in Intact Immunity Animals

By Kyle J. Norton

The liver is the largest internal organ located in the upper right portion of the abdomen, beneath your diaphragm, and above your stomach.

The liver not only plays a critical role to filter the blood coming from the intestine before passing them to other parts of the body but also protects our body against toxins by detoxifying chemicals and metabolizes drugs.

Furthermore, the liver produces bile that not only aids the digestive function in food absorption but also builds strong cell membranes, produces vitamin D and steroid hormone.

Additionally, the liver also inhibits oxidative stress by producing the antioxidant enzyme that counters the expression of free radicals in the body.

Liver cancer is a medical condition characterized by cell growth irregularly in the liver tissue.

The causes of liver cancer are associated with the alternation of cells DNA which normally begins in the cells on the surface of the inner lining.

Liver cancer at the early stage no not cause any symptoms. However, at the advanced stage, liver cancer cells can cause a wide range of symptoms including jaundice, abdominal swelling and pain, and dark urine and white stool accompanied by the general symptoms of cancers such as unintended weight loss, loss of appetite, chronic fatigue and tiredness and gastrointestinal discomforts.

The most common cause of liver cancer is infected by the hepatitis virus. However, in North America, due to the overexpression of the overweight and obese population, liver cancer may be slowly progressed from nonalcoholic fatty liver disease through cirrhosis to liver cancer.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver, and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the prevention and treatment of cancer, scientists examined a novel herbal formula NHE-06, a water-decocting extract from six natural herbals, Ficus carica, Taraxacum mongolicum, Angelica Sinensis, Lonicera japonica, Pseudo-ginseng, and Folium ginkgo. anti-liver cancer activity.

According to the tested analysis, in Vitro and Vivo, NHE-06 showed a significant suppression against NF-κB/IL-6/STAT3 signaling associated with activation of pro-inflammation in related cancer and enhancement of antitumor immunity in both cancer cell line and HCC-bearing mice.

In Vivo, the application of NHE-06 demonstrated strong activity in both preventive and therapeutic functions. 

However, NHE-06 was only effective in intact immunity mice, compared to no effect in immunocompetent mice.

Based on the findings, researchers said, " the novel formula of the anti-inflammatory NHE-06 effectively restores antitumor immunosurveillance and can be applied for prevention and/or treatment of inflammation-related cancers".

Taken altogether, dandelion may be considered a remedy for the protection against liver cancer in intact immunity patients, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The anti-inflammatory NHE-06 restores antitumor immunity by targeting NF-κB/IL-6/STAT3 signaling in hepatocellular carcinoma by Lu X1, Wo G2, Li B1, Xu C2, Wu J3, Jiang C4, Wei J. (PubMed)