Gamma-linolenic Acid Ameliorates the Symptoms of Diabetic Neuropathy

By Kyle J. Norton

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

In other words, diabetes occurs when cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

Most common types of diabetes are
* Type 1 diabetes, also known as juvenile diabetes or insulin-dependent diabetes, the most common form diabetes found in children is a condition in which the pancreas does not produce any insulin. The most common form of type 1 diabetes is caused by genetic mutation and some viruses.

* Type 2 diabetes is a medical condition characterized by insufficient insulin entering the bloodstream to regulate the glucose due to either cell in pancreas dying off or receptor sites clogged up by fat and cholesterol.
Diabetic neuropathy is a complication of patients with diabetes associated with nerve damages, ranging from pain and numbness in your legs and feet to problems with your digestive system.

Most cases of diabetic neuropathy are involved in diabetics who have a history of hyperglycemia caused by long-term high levels of glucose in the bloodstream, urinary tract, blood vessels, and heart.

Diabetic neuropathy can be classified into 4 main types, including.

* Peripheral neuropathy is the most common type of diabetic neuropathy, affecting the nerves that control the feet and legs first, followed by the hands and arms.

* The autonomic neuropathy that affects the nerves that control the heart, bladder, stomach, intestines, sex organs and eyes.

* Radiculoplexus neuropathy found mostly in older patients affects nerves that control the thighs, hips, buttocks or legs.

* Mononeuropathy, or focal neuropathy also found commonly in older patients affects the nerves that control the face, middle of the body (torso) or leg.

The exact causes of diabetic neuropathy are totally depending on the type of neuropathy. However, damage of nerves and blood vessels in the affected area has been found to induce by overtime, uncontrolled high blood sugar.

Gamma-linolenic acid is a phytochemical in the group of Omega-3, 6,9 fatty acids, belongings to the class of Lipids, found abundantly in evening primrose, borage, blackcurrant, etc.

On finding a potential plant that processes anti-diabetic activity, researchers examined the effect of gamma-linolenic acid on diabetic complications of neuropathy.

A multicenter, parallel-group, double-blind, double-dummy, randomized, noninferiority joint study include the evaluation of the efficacy and safety of γ-linolenic acid (GLA) relative to α-lipoic acid (ALA) over a 12-week treatment period in type 2 diabetes mellitus (T2DM) patients with painful diabetic peripheral neuropathy (DPN) was conducted.

According to the results of the analysis of 100 T2DM patients between 20 and 75 years of age who had painful DPN and received either GLA (320 mg/day) and placebo or ALA (600 mg/day) and placebo for 12 weeks,

* There was a significant decrease in the mean visual analog scale (VAS) and the total symptom scores (TSS). scores compared to baseline in both groups, but there were no significant differences between the groups.

* The treatment difference for the VAS (95% confidence interval [CI]) between the two groups was -0.65 (-1.526 to 0.213) and the upper bound of the 95% CI did not exceed the predefined noninferiority margin (δ₁=0.51).

* For the TSS, the treatment difference was -0.05 (-1.211 to 1.101) but the upper bound of the 95% CI crossed the noninferiority margin (δ₂=0.054).

* There were no serious adverse events associated with the treatments.

Collectively, researchers said, "GLA treatment in patients with painful DPN was noninferior to ALA in terms of reducing pain intensity measured by the VAS over 12 weeks".

Taken altogether, gamma-linolenic acid may be considered a functional food for reducing the painful diabetic neuropathy, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) γ-Linolenic Acid versus α-Lipoic Acid for Treating Painful Diabetic Neuropathy in Adults: A 12-Week, Double-Placebo, Randomized, Noninferiority Trial by Won JC1, Kwon HS2, Moon SS3, Chun SW4, Kim CH5, Park IB6, Kim IJ7, Lee J8, Cha BY9, Park TS. (PubMed)

Fermented Soy, the Natural Antioxidant

By Kyle J. Norton

Antioxidants are stable molecules that inhibit free radicals.

Total antioxidant capacity (TAC) is a measure that assesses the antioxidant status and evaluates the antioxidant response against the free radicals produced in a patient.

Free radicals are unstable atoms with an unpair of electrons on the out ring of molecules. Therefore, in order for them to become stable, they constantly seek to donate or intercept the electron from other stable atoms, leading to a chain reaction that can not be stopped until all unpaired electrons are paired or inhibited by antioxidants.

In spite of free radicals harmful effects, one must understand that cellular oxygen species (ROS), are necessary with a moderate amount to protect our body in the mediation of antimicrobial infection, detoxification of potentially toxic compounds, and elimination of cancerous and other life-threatening cells through cytotoxicity.

Free radicals such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, myeloperoxidase, superoxide dismutase, and glutathione peroxidase and antioxidants such as glutathione peroxidase, catalase, and superoxide dismutase (SOD) also act on specific oxidative pathways involving both pro-oxidant and antioxidant enzymes to maintain the healthy ratio in the body.

Normally, in a healthy individual, antioxidant enzymes produced by the liver are more than enough to counter levels of free radicals in the body. However, people with weakened immune system intake of dietary antioxidant or antioxidant supplements may be necessary.

Oxidative stress is a medical condition caused by the unbalanced ratio of the levels of free radical and antioxidant enzymes produced by the host.

In fact, free radicals exist everywhere including the airs we breathe, the thing we eat and the environment we contact, particularly, cell metabolism in the body.

Epidemiologically, overexpression of free radicals has been found to induce damage to the cell, lipid, proteins, and alternation of cell DNA, leading to chronic diseases, such as cardiovascular diseases, diabetes and particularly, cancer.

Fermented soy products are diverse varieties of soy food that are made from fermented soybeans, including miso, natto, tempeh, and soy sauce.


On finding a potential plant that processes anti-oxidative stress activity, researchers examined the relationship between in vitro antioxidant capacity of soy sauces and its impact on lipid oxidation in raw and cooked beef patties during 10 days of refrigerated storage.

According to the results of the analysis of 3 commercial soy sauces including industrially fermented soy sauce (IS), traditionally fermented Korean soy sauce (KS), and mixed soy sauce (MS),

* In vitro antioxidant capacity, KS showed the highest total phenol content, whereas IS and MS had a higher Fe2+ chelating activity than KS (P < .05).

* Heat treatment decreased total phenol content but increased Fe2+ chelating activity of soy sauces (P < .001).

* In both raw and cooked beef patties, the addition of IS or MS caused a lower 2-thiobarbituric acid reactive substances (TBARS) level than KS throughout the overall storage period (P < .05).

Collectively, researchers suggest, "the Fe2+ chelating activity of soy sauce may be one of the major mechanisms in preventing lipid oxidation in meat products".

Taken altogether, potato may be considered a functional food for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Relationship between the antioxidant capacity of soy sauces and its impact on lipid oxidation of beef patties by Ham YK1, Hwang KE2, Song DH3, Choi JH2, Choi YS4, Kim HW. (PubMed)

Herbal Enchinanea Enhances the Immune Response Against H9N2 Avian Influenza Virus

By Kyle J. Norton

Influenza, also known as the flu, is an infectious disease caused by an influenza virus.

There are 3 types of flu influenza: A, B, and C. the influenza virus A and B are considered seasonal flu that causes sniffling, aching, coughing, and running and stuffy nose and fever to over 20% of the general population.

Influenza virus types C tends to cause mild upper respiratory infections, similar to those of cold.

Healthy individuals who have influenza are usually recovered within one week.

However, people with immature and weakened immune system such as young children under age 5, adults older than age 65 residents of nursing homes and other long-term care facilities, chronic illnesses, such as asthma, heart disease, kidney disease, liver disease, and diabetes are not only associated with the risk of influenza but also increase the risk of influenza deadly complication.

Infection is a condition that caused the invasion of stimuli and micro pathogens, including viral infection.

A viral infection is a disease caused by the successful entering and multiplying of a virus in the body.

Anti-viral effects are an act of certain substances to cause the destruction of a virus.

In the acute phase of viral infection, depending on the types of viruses, the viruses after entering the body start to attack the specific host cells. The cold and flu virus will attack the cells in the respiratory system and the human immunodeficiency virus (HIV), which causes AIDS, will attack the white blood cells of the immune system,

The viral infection o\has been known to carry over some different stage, after successfully attaching to the host cell, the virus to release its mRNA into the host cell, leading to the recruit of the host cell's enzymes to accelerate the viral multiplying, then breaking free from the host cell to start the cycle all over again.

H9N2 is a subtype of the species Influenza A virus. The H9N2 influenza strain had caused illness in several children aged nine months to 5 years in Hong Kong with the latest occurring in December 2009, according to statistics.

Echinacea also is known as purple coneflowers, is a flowering plant of the genus Echinacea, belongings to the family Asteraceae, native to eastern and central North America. The herb has been used in traditional and herbal medicine to treat or prevent colds, flu, infections by stimulating the immune function, etc.

On finding a potential phytochemical for the treatment of viral diseases, researchers examined the effect of Immulant® (IMU) (a commercial product based on Echinacea and Nigella sativa) on stress-induced by dexamethasone (DEX) in chickens vaccinated (VAC) against the H9N2 avian influenza virus (AIV-H9N2).

The study included vaccinated chickens (at 10 days of age) that were injected daily with DEX for three days pre-vaccination and for three days pre-challenge and orally administered 1% IMU for 6 weeks post-vaccination (PV), following by the challenge of intranasal AIV-H9N2 at 28 days PV.

According to the analysis of the results of serum, blood, tracheal and cloacal swabs and tissue samples were collected in the 1st and 4th weeks,

* The formula showed significant changes (P ≤ 0.05) in oxidative stress and antioxidant biomarkers (malondialdehyde, nitric oxide, and reduced glutathione), hematological and immunological parameters, final live weights, relative organ weights and histopathological lesions between the VAC+DEX group and the VAC group.

* IMU significantly increased protection rates post-challenge, HI antibody titers and heterophil phagocytic activity and decreased DEX-induced stress and virus shedding titers.

In other words, IMU inhibited the initiation and progression of AIV-H9N2 in the induction of infection through several antiviral mechanisms.

After talking about other factors into account, researchers said, "oral administration of 1% IMU for six weeks can enhance the immune response after AI-H9N2 vaccination and reduce the pathogenicity of infection in stressed chickens".

Taken altogether, herbal Enchinanea used alone or combined with other medicines may be considered adjunct therapies in the treatment of AIV-H9N2 infection, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Comparative immune response and pathogenicity of the H9N2 avian influenza virus after administration of Immulant®, based on Echinacea and Nigella sativa, in stressed chickens by Eladl AH1, Arafat N2, El-Shafei RA3, Farag VM4, Saleh RM5, Awadin WF. (PubMed)

Hibiscus, the Natural Anti Bacterial Infection Functional Remedy

By Kyle J. Norton

Infectious diseases are a medical condition caused by pathogenic microorganisms, including bacteria, viruses, parasites or fungi.

Most cases of infectious diseases are contagious by spreading directly or indirectly, from one person to another.

In other words, if you kiss, or are coughed or sneezed on by an infectious person, you are at risk of developing the same infectious disease.

According to the statistic provided by the World Health Organization, infectious diseases were ranked in the top ten causes of death worldwide in 2016.

A bacterial infection is an infected caused bacteria.

Infection can be acute or chronic. In the acute phase of infection, after receiving the messages from the central nervous system related to the danger of microbial infection, the immune macrophages in the first line of defense stimulates the production of blood palette to the cover the wound and pro-inflammatory cytokines to the site of the infection to kill off pathogens which try to enter the body.

However, overproduction of pro-inflammatory cytokines in the acute phase of infection has also killed off or damage to the nearby healthy cells, leading to the formation of scars.

In most cases in a healthy individual, depending on the size of the wound, the immune system can easily eradicate all foreign invaders and the wound is recovered within days and weeks.

Symptoms of the acute infection include gastrointestinal discomforts, such as congestion vomiting or nausea, and diarrhea, short term joint or muscle pain, fever, headache, skin rash and cough, Some patients with acute infection also experience symptoms of swollen lymph nodes, an indication of the body is fighting infection.

The most common types of bacterial infections are bacterial meningitis, otitis media, pneumonia, and tuberculosis.

Roselle (Hibiscus sabdariffa) is a species of Hibiscus probably native to West Africa used in traditional Chinese medicine to resolve phlegm and food stagnation and regulate the Liver to aid digestion, promote weight loss, reduce cholesterol, improve circulation, lower blood pressure.

With an aim to find natural food for the treatment of infectious diseases,, researchers compared the effects of rude, phenolic-rich extracts (CPREs) isolated from different sources, such as Hibiscus sabdariffa (H. sabdariffa, Roselle), Brassica oleracea var. capitata f. Rubra (B. oleracea, red cabbage) and Beta vulgaris (B. Vulgaris).

According to the tested differentiation, the administration of CPREs showed potential antibacterial and antifungal activities.

According to chemical analysis, total anthocyanins content (TAC), total phenolic content (TPC) and total flavonoid content (TFC) and other compounds found in all three CPREs demonstrated strong antimicrobial effects against pathogenic bacteria and fungi.

Hibiscus sabdariffa CPRE (HCPRE) at a dose of 50 μg/mL exhibited signs of asymmetric, wrinkled exterior surfaces, cell deformations and loss of cell shapes against Staphylococcus aureus DSM 1104 and Klebsiella pneumonia ATCC 43816.

The injection of CPRE also led to cell clumping, malformations, blisters, cell depressions, and diminished cell numbers.

In other words, CPRE induced the death of bacterial cells and loss of cell contents.

Taken altogether, Hibiscus sabdariffa may be considered a remedy for the prevention and treatment of infectious diseases, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antimicrobial Activity and Chemical Constitution of the Crude, Phenolic-Rich Extracts of Hibiscus sabdariffa, Brassica oleracea and Beta vulgaris by Abdel-Shafi S1, Al-Mohammadi AR2, Sitohy M3, Mosa B1, Ismaiel A1, Enan G1, Osman A. (PubMed)

Brassica Oleracea Vegetables and Juices Inhibits the Onset of Breast Cancer in Vitro

By Kyle J. Norton

Cancer is a class of diseases in which a group of cells growing and multiplying disorderly and uncontrollably in our body.

The prevalence of breast cancer has been acknowledged in the scientific community worldwide. Breast cancer widespread in women in Southeast Asian as a result of over 2 decades of economic prosperity caused by an unhealthy diet is a major concern.

The women's breasts are made up of specialized tissue that produces milk (glandular tissue) and fatty tissue. The size of a women's breast is totally determined by the amount of fat.

Breast cancer is a medical condition characterized by cell growth irregularly and disorderly in the breast tissue.

Most cases of breast cancer start in the cell on the surface of the inner lining of the breast tissue before spreading into deeper layers of the breast.

Breast cancer is first noticed as a painless lump in the breast or armpit and most often discovered by the women themselves.

Breast skin irritation or dimpling, nipple pain, nipple retraction (turning inward), redness and scaliness that cannot be healed within 3 weeks are also the signs and symptoms of breast cancer.

According to statistics, the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.

People who inherited the genetic preposition of BRCA1 and 2 are associated with over 60% of the risk of breast cancer.

However, an unhealthy diet and lifestyle are some of the preventable risk factors that form a major cause of breast cancer onset.

In postmenopause, weight control is the major factor throughout life that appears to prevent breast cancer after menopause.

Daily physical activity and reduced intake of alcohol throughout life are associated with reduced risk of developing pre- and postmenopausal breast cancer, however, smoking during adolescence or early adulthood increases later risk of breast cancer.

Interestingly, in the depth discussion of the diet pattern in the risk of breast cancer, researchers do not find the direct link to breast cancer risk.

These results suggested by actively following a healthy lifestyle and moderate exercise, the risk of breast cancer can be decreased substantially.

Kale is a species of Brassica Oleracea, belongings to the family Brassicaceae, native to coastal southern and western Europe. The veggie leave is highly nutritious cultivated as foods in most part of Europe.

On finding a potent compound for the prevention and treatment of cancers, researchers examined the antiproliferative activity of juice obtained from leaves of several varieties of Brassica oleracea on both estrogen receptor (ER)-positive (ER+; MCF-7 and BT474) and ER-negative (ER-; MDA-MB-231 and BT20) human breast cancer cell lines.

At low concentrations to final concentration 5-15 mL/L,
* All cauliflower varieties tested suppressed cell proliferation in a dose-dependent manner.

* Although no evidence of apoptosis was found, cancer cell growth inhibition was accompanied by significant cell death at the higher juice concentrations.

* All juices showed a preference in the inhibition of breast cancer cells compared with other mammalian cell lines, such as ECV304, VERO, Hep2, 3T3, and MCF-10A.

In the cell levels, all juices exerted the inhibition of proliferation associated with significantly reduced CDK6 expression and an increased level of p27 involved cell division and cell cycle arrest, respectively, in ER+ cells but not in ER- cells.

Based on the results, researchers said, "the edible part of Brassica oleracea contains substances that can markedly inhibit the growth of both ER+ and ER- human breast cancer cells, although through different mechanisms".

Taken altogether, kale, a member of cruciferous vegetables may be considered a functional food for the treatment of breast cancer, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Mechanisms of action and antiproliferative properties of Brassica oleracea juice in human breast cancer cell lines by Brandi G1, Schiavano GF, Zaffaroni N, De Marco C, Paiardini M, Cervasi B, Magnani M. (PubMed)

Not Cooked Potato but French Fried that Elevates the Risk of Obesity and Type 2 diabetes

By Kyle J. Norton

Chronic diseases are medical conditions that last more than 3 months depending on the type of diseases.

In other words, chronic diseases generally cannot be prevented or cured by medication, nor do they just disappear.

According to the statistics, chronic diseases affect millions of people worldwide, leading to the death of 35 million people in 2005, including many young people and those in middle age.

The most common types of chronic diseases in the Western world are cardiovascular diseases and diabetes.

Cardiovascular disease (CVD) is a group of conditions associated with the heart and blood vessels.

Heart disease is a class of diseases associated with interruption of blood flow in the blood vessel or damage of the heart tissue, including coronary artery diseases (CAD) such as angina and myocardial infarction.

Type 2 diabetes is a medical condition characterized by insufficient insulin entering the bloodstream to regulate glucose due to either cell in the pancreas dying off or receptor sites clogged up by fat and cholesterol.

Some researchers also suggested that people with certain medical conditions such as polycystic ovary syndrome. and high blood pressure is more prone to the onset of the disease.

The most common symptoms of type 2 diabetes are an increased thirst that won't stop with water intake, increased hunger (especially after eating), dry mouth, frequent urination, and unintentional weight loss.

Obesity is a medical condition caused by excess body fat accumulated to some extent that impacts personal health. The hallmark of obesity is attenuated metabolism and structural cell changes in the obese fat observed by reducing metabolic activity.

Potato is a genus Solanum, belongs to the family Solanaceae. The veggie is a good source of protein and according to the statistic, the annual diet of an average global citizen is about 33 kg (72.6 Lbs) of potato. It now is growing worldwide in a suitable climate for commercial profits and health benefits, thus its consumption is extremely variable and rapidly changing.

On finding a potential plant for the prevention and treatment of chronic diseases, researchers evaluated the relation between intake of potatoes and risks of obesity, T2D, and CVD in apparently healthy adults.

According to the search of the databases of MEDLINE, Embase, the Web of Science, and the Cochrane Central Register of Controlled Trials involved in the intervention and prospective observational studies that identified a total of 13 studies, including 5 studies that were related to obesity, 7 studies that were related to T2D, and one study that was related to CVD,

* The association between potatoes (not including french fries) and adiposity was neutral in 2 studies and was positive in 2 studies.

* For T2D, 2 studies showed a positive association, whereas 5 studies showed no or a negative association with intake of potatoes and T2D.

* For CVD, no association was observed.

Most importantly, French fries were positively associated with T2D and obesity in all studies.

Collectively, researchers said, "The identified studies do not provide convincing evidence to suggest an association between intake of potatoes and risks of obesity, T2D, or CVD"

And, "French fries may be associated with increased risks of obesity and T2D".

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Potatoes and risk of obesity, type 2 diabetes, and cardiovascular disease in apparently healthy adults: a systematic review of clinical intervention and observational studies by Borch D1, Juul-Hindsgaul N1, Veller M1, Astrup A1, Jaskolowski J1, Raben A. (PubMed)

Lycopene Protects the Blood Vessels Against Vascular Complications in Type 2 Diabetics

By Kyle J. Norton

Vascular tissues are tissues with a lot of blood vessels, formed part of the circulatory system that carries blood to nourish the body tissues and organs including veins, arteries, and capillaries in the human body.

Vascular diseases are a group of diseases associated with an abnormal condition of the blood vessels (arteries and veins). In other words, vascular diseases are diseases that affect your circulatory system, such as peripheral artery disease.

 Diabetes is a medical and chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose. 

Most cases of diabetes are either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol. 

The vascular complications of diabetes can be either microvascular that induce

* Diabetic retinopathy, is a diabetic complication caused by damage to the blood vessels of the retina.

* Diabetic nephropathy is the diabetic complication that damages the kidneys.

* Diabetic neuropathy is the diabetic complication that damages nerves in the legs and feet.

Macrovascular diseases that include 

* Diabetic coronary artery disease is is the most common type of heart disease associated with the hardening and narrowing arteries that supply blood to the heart muscle.

* Diabetic peripheral disease is a type of heart disease caused by narrowed arteries that reduce blood flow to your limbs.

* Diabetic cerebral vascular disease is a condition that affects the blood vessels of the brain and cerebral circulation.

Most cases of diabetes are the results of longer-term hyperglycemia caused by an unhealthy healthy lifestyle such as uncontrolled diet and physical inactivity. Failure to maintain the right blood glucose over time not only induces vascular complications but also exacerbates the risk of mortality.

Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.

With an aim to find a potential compound for the treatment of diabetes complications, researchers examined the effect of lycopene on vascular complications associated with endothelial progenitor cells (EPCs).

Based on the number and the function of EPCs related to the advanced glycation end products (AGEs) generated in DM patients, researchers found that
* Lycopene injection exerted its natural antioxidant activity that protects EPCs under the microenvironment of AGEs from damage.

* At the concentration of 10μg/mL, Lyc improves cell proliferation and has low cytotoxicity in the presence of AGEs.

* Lycopene also protects the vascular cells against the S phase of the cell cycle arrest, apoptosis rate by decreasing autophagic reaction between ROS and mitochondrial membrane potential (MMP) in the promotion of EPC survival associated with the activation of autophagy inhibitors,
3-Methyladenine (3-MA).

The results strongly suggested that Lyc promotes EPCs survival and protect EPCs from apoptosis and oxidative autophagy induced by AGEs against the vascular complications in diabetes subjects.

Dr. Zeng YC, the lead scientist wrote in the final report, "This study provides new insights into Lyc protective mechanism of AGEs-induced oxidative autophagy in EPCs from DM patients and offers a new therapy for DM vascular complications".

Taken altogether, lycopene found in tomato may be considered supplements for the prevention of vascular complications in type 2 diabetics, pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Lycopene Ameliorated Oxidative Stress and Inflammation in Type 2 Diabetic Rats by Zheng Z1, Yin Y1, Lu R1, Jiang Z. (PubMed)

Lycopene Inhibited the Parameters Associated with Onset of Liver Cancer

By Kyle J. Norton

The liver is the largest internal organ located in the upper right portion of the abdomen, beneath your diaphragm and above your stomach.

The liver not only plays an essential role that filters the blood from the digestive system but also produces bile to build strong cell membranes, produce vitamin D and steroid hormones.

Furthermore, the liver also aids digestive function to absorb nutrients from food intake, and protect the body against free radicals in the body through its antioxidant capacity.

Liver cancer is chronic a condition characterized by out of controlled growth of hepatocellular cells in the liver due to DNA alternation. 

Since the organ is a soft tissue with less nerve, most liver cancer patients are diagnosed in the later stage of cancer. 

 Liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide. According to the statistic, in the US, approximately, 42,030 new cases of liver cancer will be diagnosed in 2019, including 29,480 in men and 12,550 in women.

Sadly, liver cancer also will cause the death of approximately 31,780 people, including 21,600 men and 10,180 women in 2019. Believe it or not, liver cancer death rates have increased by over 2% per year since 2007

Hepatocellular carcinoma (HCC) is a common form of primary liver cancer.

The grade of liver cancer is depending on the tendency of spreading. Low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancers indicate otherwise.

Out of many risks associated with the onset of liver cancer, some researchers that long-term excessive alcohol drinking may be the culprit which causes the rise of liver cancer in the US.

Linda Carroll wrote on the NBC news." Severe alcohol-related liver disease is on the rise, a new study suggests. Experts say the increase may be due to heavy binge drinking, especially in young adults.

And, "...while there has been little change in the rate of people developing alcoholic fatty liver disease, there appears to be an increase in those who are at greater risk of cirrhosis, liver cancer, and death, according to the study published in JAMA"

Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.


On finding a potential compound for the prevention of liver cancer, researchers examined the effects of lycopene extracted from tomatoes (LycT) on N-Nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis.

In a study of female BALB/c mice randomly divided into four groups, the Control, NDEA (200 mg NDEA/kg b.w. given i.p.), LycT (5 mg/kg b.w. given orally on alternate days) and LycT + NDEA group, researchers found that

* Lycopene treament inhibited the uncontrolled proliferation in the liver of NDEA associated with the high expression of cell-proliferation (P ≤ 0.001) in NDEA mice observed by the increased expression of genes (PCNA, Cyclin D1, and p21) associated with tumorigenesis compared to control.

* Furthermore, elevated expression of parameters associated with cancer expression in NDEA mice were also inhibited by the injection of lycopene extract compared to control.

* The aforementioned parameters correlated to the alterations in hepatic ultrastructure in the NDEA group were also inhibited by the lycopene extract.

* Moreover, according to the hepatic electron micrographs, LycT + NDEA group showed also increased macrophages, apoptotic bodies and well-differentiated hepatocellular carcinoma (HCC), compared to undifferentiated HCC observed in the NDEA treated group.

Based on the findings, researchers said, "This study demonstrates that dietary supplementation with LycT has a multidimensional role in preventing HCC development".

Taken altogether, lycopene found in tomato may be considered supplements for the prevention of liver cancer pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary Tomato Powder Inhibits High-Fat Diet-Promoted Hepatocellular Carcinomawith Alteration of Gut Microbiota in Mice Lacking Carotenoid Cleavage Enzymes by Xia H#1, Liu C#1, Li CC#1, Fu M2, Takahashi S2, Hu KQ1, Aizawa K1,2, Hiroyuki S2, Wu G3, Zhao L3, Wang XD. (PubMed)
(2) Lycopene modulates cellular proliferation, glycolysis and hepatic ultrastructure during hepatocellular carcinoma by Gupta P1, Bhatia N1, Bansal MP1, Koul A. (PubMed)
(3) Severe alcohol-related liver disease on the rise, study finds by Linda Carroll (NBC News)

Devil's claw (Harpagophytum procumbens), the Anti-Inflammatory Remedy

By Kyle J. Norton

Inflammation is the natural response of the immune system macrophages, the first line of defense in stimulating the production of inflammatory cytokines to protect our body against the infection caused by foreign microorganisms during the acute phase of body damage and injury.

Truly, the main focus of inflammation is to repair damage and injury.

Most cases of infection associated with inflammation are stopped at the acute phase. The wound or injury is slowly recovered.

However, overexpression of inflammatory cytokines in most cases can cause improper healing with scar formation or the death of nearby cells.

Any inflammation that lasts more than 8 weeks is considered chronic inflammation.

Believe it or not, worldwide, 3 of 5 death are results from chronic inflammatory diseases like stroke, chronic respiratory diseases, heart disorders, cancer, obesity, and diabetes.

In the US, chronic inflammatory diseases affect more than 50 million Americans each year.

Diseases associated with low-grade inflammation include diabetes and cardiovascular.

Conventionally, Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most common medical drugs such as aspirin. ibuprofen in reducing inflammation associated with pain-relieving.

On finding a natural ingredient for the prevention and treatment of liver diseases, scientists investigated the prepared an extract of Euphrasia officinalis, a traditional folk medicine, to synthesize gold nanoparticles (EO-AuNPs) anti-inflammatory effects on lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages.

Devil's claw also known as the wood spider, is a plant of genus Harpagophytum in the family of Pedaliaceae, native to South Africa. 

The plant has been used as an herb in traditional and herbal medicine to treat fever, rheumatoid arthritis, skin, gallbladder, pancreas, stomach and kidneys conditions, etc.

According to tested analysis, the successful synthesis of AuNPs by E. officinalis showed significant anti-inflammatory activities detected by a model of LPS-induced upregulation of inflammatory mediators and cytokines.

More precisely, AuNPs by E. officinalis inhibited the levels of nitric oxide (NO), nitric oxide synthase (iNOS), tumor necrosis factor-α (TNF-α), IL-1β, and IL-6 in RAW 264.7 cells.

Furthermore, EO-AuNPs exhibited little cytotoxicity in RAW 264.7 cells at 100 µg/mL concentration after 24 hours.

Pretreatment with EO-AuNPs also significantly reduced the phosphorylation and degradation of inhibitor kappa B-alpha and inhibited the nuclear translocation of NF-κB p65 involved the production of pro-inflammatory cytokines.

Additionally, EO-AuNPs suppressed LPS-stimulated inflammation by blocking the activation of JAK/STAT pathway associated with cytokines and growth factors.

Based on the results, researchers suggest, "The synthesized EO-AuNPs showed anti-inflammatory activity in LPS-induced RAW 264.7 cells, suggesting they may be potential candidates for treating inflammatory-mediated diseases".

Taken altogether, Dandelion may be considered an anti-inflammatory remedy, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Green synthesis of gold nanoparticles using Euphrasia officinalisleaf extract to inhibit lipopolysaccharide-induced inflammation through NF-κB and JAK/STAT pathways in RAW 264.7 macrophages by Liu Y1, Kim S2, Kim YJ1,2, Perumalsamy H2, Lee S3, Hwang E4, Yi TH. (PubMed)

Herbal Cleaver(Galium aparine), inhibits the Melanoma Cell Metastasis in Vitro

By Kyle J. Norton

Skin melanoma is a skin cancer characterized by the alternation of the pigment-containing cells known as melanocytes. However, in rare cases, melanoma can also occur in the mouth, intestines, or eye.

Most cases of melanoma start in melanocytes on skin before spreading to the nearby tissue. In the advanced stage, the cancer cells can also travel a distance away from the originated site to infect other tissues and organs, leading to secondary metastasis, through the circulation of blood and fluids.

The most common sites of melanoma metastasis are the lung and breast.

The most common symptoms are visible by examing the change of skin, including the sores that can not heal itself, redness or swelling, persistent itching, tenderness and pain and particular, change of skin color and bleeding off of a mole compared to the normal moles.

The 4 most common types of skin melanoma include
* Superficial spreading melanoma, the type of cancer has a tendency to spread grow outward and spread across the surface of the skin, accounted for 70% of all melanoma skin cancer.

* Nodular melanoma normally grows down into the skin and has a tendency to spread more quickly than other types of melanoma skin cancer.

* Lentigo malignant melanoma, most common in the older population, making up approximately 15% of all melanoma skin cancer.

* Acral lentiginous melanoma, most common in people with darker skin. Cancer first moves outward before spreading deeper into the skin.

According to the statistics provided by the American Cancer Society, in 2019, approximately, 96,480 new melanomas will be diagnosed (about 57,220 in men and 39,260 in women) in the US. The condition also causes the death of 4,740 men and 2,490 women.

Believe it or not. most cases of melanoma are found in older adults. The average age diagnosed with melanoma is 63.

Cleaver is a herbaceous annual plant, genus Galium, belonging to the family Rubiaceae, native to North America and Eurasia. The herb has been used over thousands of years in herbal and traditional medicine as mild diuretic and blood and lymphatic cleanser and to treat psoriasis, skin conditions, glands, tonsillitis, bladder infections, prevent small kidney stone, etc.

On finding a potential compound for the treatment of skin diseases, researchers investigated the Gallic acid (GA) found in herbal Cleaver in the inhibition of the growth of human cancer cells in vitro and in vivo.

GA decreases the expression of MMPs MMPs mRNA levels in A375.S2 human melanoma cells in stimulating the cancer cell metastasis.

Furthermore, GA processed antimetastatic potential by decreasing the invasiveness of cancer cells.

Moreover, this action of GA was involved in the Ras, p-ERK signaling pathways with function to communicate a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell to induce the inhibition of MMP-2 associated with cancer spreading in A375.S2 human melanoma cells.

 

 Based on the findings, researchers said, " These data, therefore, provide evidence for the role of GA as a potential cancer chemotherapeutic agent, which can markedly inhibit the invasive capacity of melanoma cells".

 o

Taken altogether, Comfrey may be considered a remedy to inhibit cancer call spreading, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Gallic acid inhibits the migration and invasion of A375.S2 human melanoma cells through the inhibition of matrix metalloproteinase-2 and Ras by Lo C1, Lai TY, Yang JS, Yang JH, Ma YS, Weng SW, Lin HY, Chen HY, Lin JG, Chung JG. (PubMed)

Common Fig or Fig (Ficus carica) Gobbles Up Triple-Negative Invasive Breast Cancer in Vitro

By Kyle J. Norton

The women's breasts are made up of specialized tissue that produces milk (glandular tissue) and fatty tissue. The size of a women's breast is totally determined by the amount of fat.

Breast cancer (malignant breast neoplasm) is cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. There are also rare cases that breast cancer starts in other areas of the breast.

At the advanced stage, after colonizing the entire breast the adance stage, malignant cancers can travel a distance away to infect other healthy cells and tissue.

The exact causes of breast cancer are unknown.

In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of women is 1/8.

Unlike general breast cancer which processes either receptors for estrogen or progesterone and/or receptors with a protein called HER2, triple-negative breast cancer is a form of breast cancer that does not share the aforementioned characteristics.

In other words, triple-negative breast cancer does not have receptors of estrogen or progesterone or genetic preposition.

More importantly, triple-negative breast cancer was found to infect women under the age of 40 and women of African or Asian ancestry in the US, compared to breast cancer in the White.

Particularly, according to the epidemiological study, younger women and in women of African ancestry are susceptible to a higher risk of basal-like triple-negative breast cancers.

Compared to the malignant nature, triple-negative and basal-like breast cancers are highly invasive which can grow and spread quickly to other tissues and organs through lymph and blood.

Also compared to other breast cancers, with decreased risk after 5 years, triple-negative breast cancers have a substantial higher recurrent rate within 5 years after treatment.

Fig is a species of F. Carica, belonging to the family Moraceae. It is a deciduous shrub, native to Southeast Asia. The tree can grow to a height of 33 ft and the fruit can be as large as 2.0 inches.

On finding a natural compound or whole food for the treatment of cancer, researchers investigated the effects of Ficus carica leaves on triple-negative breast cancer MDA-MB-231 cells.

According to the tested differentiation, the application of Ficus carica leaves promoted the gene expressions associated with apoptosis.

Furthermore,  Ficus carica leaves also demonstrated significant activity in the induction of S phase cell cycle arrest by changing the expression of cyclin-dependent kinases involved in the cancer cell cycle division.

The cell mobility associated with metastasis. in the cells was also inhibited by the application.

Most importantly, 2 chemical compounds bergapten and psoralen found in the F. Carica leaves also had similar anticancer effects as F. Carica leaf extracts.

Based on the results, researchers wrote, "F. Carica leaves might be a good source to develop drugs for suppressing cancer-cell growth and migration to treat triple-negative breast cancers".

Taken altogether, common fig or fig (Ficus carica)  may be considered a remedy for the prevention and treatment of triple-negative breast cancer, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Extracts and components of Ficus carica leaves suppress survival, cell cycle, and migration of triple-negative breast cancer MDA-MB-231 cells by Yu Zhang,1 Youzhong Wan,1,2 Bo Huo,1 Boyuan Li,1 Yue Jin,1 and Xin Hu. (PMC)

Broccli Processes Anti Nasopharyngeal Cancer Activity

By Kyle J. Norton

Cancers are a class of chronic and medical conditions characterized by cells growth irregularly and disorderly in the tissue of a specific organ.

Most cases of cancer start in the cell on the surface of the inner lining of organ tissue caused by the alternation of the cell DNA.

According to the National Cancer Institute, approximately 38.4% of men and women will be diagnosed with cancer at some point during their lifetimes, based on the 2013–2015 data.

In 2017, about15,270 children and adolescents ages 0 to 19 were diagnosed with cancer. Cancer in the same year also causes the death 1,790 of children and adolescents Americans.
The nasopharynx is the upper part of the pharynx, connecting with the nasal cavity above the soft palate that allows a person to breathe through the nose.

Nasopharyngeal cancer is a medical condition characterized by cells growth irregularly and disorderly in the tissues of the nasopharynx.

Most cases of nasopharyngeal cancer start in the cells on the surface of the inner lining of the nasopharynx.

According to the statistics provided by the American cancer society, nasopharyngeal cancer (NPC) is quite rare in the United States). The risk of cancer is less than one case for every 100,000 people.

Epidemiologically, some patients at this stage may also experience symptoms of frequent ear infections, hearing loss and headaches.

The exact causes of nasopharyngeal cancer are unknown. Gender, family history, ethnicity, where you live, poor diet, infected by the Epstein-Barr virus are some of the prevalent factors of nasopharyngeal cancer.
 
On finding a potential plant that processes anti-cancer activity researchers compared the effects investigate the role of miRNAs from broccoli in human nasopharyngeal cancer (NPC).

Where microRNAs (miRNAs), a small non-coding RNA molecule found in plants, animals and some viruses have been documented as having an important role in the development of cancer.

According to the analysis of a total of 84 conserved miRNAs and 184 putative novel miRNAs in broccoli by sequencing technology, the most abundant miR156a mimic inhibited the EMT of NPC cells in vitro.

The molecular genetics 3' UTR of Junctional adhesion molecule A (JAMA) associated with cancer cell migration and tight junctions was inhibited by the miR156a mimic on the tested EMT of NPC.

Collectively, researchers said, "These miRNA profiles of broccoli provide a fundamental basis for further research. Moreover, the discovery of miR156a may have clinical implications for the treatment of patients with NPC".

Taken altogether, broccoli which consists of microRNAs may be considered a functional food for the prevention and treatment of atherothrombotic diseases, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) miR156a Mimic Represses the Epithelial-Mesenchymal Transition of Human Nasopharyngeal Cancer Cells by Targeting Junctional Adhesion Molecule A by Tian Y1, Cai L1, Tian Y2, Tu Y1, Qiu H1, Xie G1, Huang D1, Zheng R1, Zhang W. (PubMed)

Cranberry Inhibits Herpes simplex virus 1 and 2 (HSV-1, 2) Infection

By Kyle J. Norton

Herpes simplex virus 1 (HSV-1) primarily causes oral herpes, including cold sores and fever blisters around the mouth and on the face.

Herpes simplex virus-2 (HSV-2) primarily causes genital herpes and  genital herpes outbreaks

Infection can be acute or chronic. In the acute phase of infection, after receiving the messages from the central nervous system related to the danger of microbial infection, the immune macrophages in the first line of defense stimulates the production of blood palette to the cover the wound and pro-inflammatory cytokines to the site of the infection to kill off pathogens which try to enter the body.

However, overproduction of pro-inflammatory cytokines in the acute phase of infection has also killed off or damage to the nearby healthy cells, leading to the formation of scars.

In most cases in a healthy individual, the immune system can easily eradicate all foreign invaders and the wound is recovered within days and weeks.

Symptoms of the acute infection include gastrointestinal discomforts, such as congestion vomiting or nausea, and diarrhea, short term joint or muscle pain, fever, headache, skin rash and cough, Some patients with acute infection also experience symptoms of swollen lymph nodes, an indication of the body is fighting infection.

In chronic infection, the symptoms are most vague or no specific symptoms, including bronchitis and asthma, persistent low-grade chronic joint and muscle pain, or swelling and the alternations between diarrhea and constipation, bloating, or heartburn, In other words, the symptoms are totally depended on the location of the low-grade inflammation.

Most cases of infection except those of viral infection are treated by topical antibiotic cream and/or oral antibiotics.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of skin infection, researchers investigated the effects of cranberry (Vaccinium macrocarpon Ait.) extracts Oximacro(®) against Herpes simplex type 1 (HSV-1) and type 2 (HSV-2) infections.

In vitro, the novel cranberry extract Oximacro(®) and its purified A-type proanthocyanidins (PACs-A) inhibited HSV-1 and HSV-2 replication.

Furthermore, Oximacro(®) prevented the adsorption of HSV-1 and HSV-2 to target cells.

Moreover, Oximacro(®) and its PACs-A targeted the viral envelope glycoproteins gD and gB to enter cells, thus resulting in the loss of infectivity of HSV particles.

Most importantly, Oximacro(®) completely exerted continuously its anti-HSV activity even at acidic pHs (3.0 and 4.0) and in the presence of 10% human serum proteins, and conditions that mimic the physiological properties of the vagina.

Based on the findings, researchers said, "Oximacro(®) as an attractive candidate for the development of novel microbicides of natural origin for the prevention of HSV infections".

Taken altogether, cranberry may be considered immune-modulatory remedy, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibition of herpes simplex type 1 and type 2 infections by Oximacro(®), a cranberry extract with a high content of A-type proanthocyanidins (PACs-A) by Terlizzi ME1, Occhipinti A2, Luganini A3, Maffei ME4, Gribaudo G. (PubMed)

Cruciferous Vegetables Inhibit the Risk of Gastric/Stomach Cancer

By Kyle J. Norton

Gastric cancer is a medical condition characterized by irregular and uncontrollable cell growth in the stomach.

Most cases of gastric cancer start in the cells on the surface of the inner lining of stomach tissue.
Due to the small size at the early stage, gastric cancer is asymptomatic.

However, at the later stage, after penetrating into the deeper layers of the stomach, the cancer cell may travel a distance away to infect other healthy tissues and organs, leading to secondary metastasis.

Researchers do not know why some people with the same health condition are susceptible to the risk of gastric cancer, while others do not. The exact causes of gastric cancer are also unknown. However, some researchers suggested that Age, diet, and stomach disease, such as can increase the risk of developing gastric cancer.

The most common symptoms of gastric cancer are stomach pain, nausea and vomiting, loss of appetite,... and indigestion. However, common symptoms of unexpected weight loss and stomach ulcers can only be found in gastric cancer while iron-deficiency anemia.

According to the statistics provided by the American Cancer Society, in 2019, approximately, 27,510 cases of stomach cancer will be diagnosed (17,230 in men and 10,280 in women) and 11,140 people will die from gastric cancer (6,800 men and 4,340 women).

Overall, the 5-year survival rate for people with gastric cancer is 31%. Cancer diagnosed at the localized stage have a 5 years survival rate of 67%.

Out of many risk factors associated with the onset of cancer, aging may be one of the major risk factors that cause the disease onset as cancer has been found to have a peak incidence between 50 and 70 years of age.

On finding a potential plant that processes anti-invasive cancer activity researchers examined the relationship between consumption of cruciferous vegetables (CV) in the risk of gastric cancer.

According to the meta-analysis that summarize available evidence from epidemiological studies published reports of CV intake and gastric cancer were identified using MEDLINE (PubMed), EMBASE, and Web of Science databases through to the end of September 2012, including 16 case-control and 6 prospective studies,

* The pooled studies showed a significantly inverse association between CV (relative risk = 0.81; 95% confidence interval, 0.75-0.88) intake and gastric cancer risk, with little heterogeneity (Q = 27.27, P = 0.292, I(2) = 12.0%). 

* In a separate analysis, the case-control studies of CV intake yielded significant results compared to the borderline statistical significance of CV intake yielded in the prospective studies.

* Moreover, significant results were consistent for high-quality studies, for North American, European, and Asian studies, for studies on males, and for studies on non-cardia gastric cancer.

Based on the findings, researchers said, "... this meta-analysis provides evidence that high intake of CV was inversely associated with the risk of gastric cancer and non-cardia gastric cancer in humans.

Taken altogether, CV with rich phytochemicals may be considered a functional food for the prevention and treatment of gastric cancer, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cruciferous vegetable consumption and gastric cancer risk: a meta-analysis of epidemiological studies by Wu QJ1, Yang Y, Wang J, Han LH, Xiang YB. (PubMed)

Vegetables and Fruits Show Inverse;y Associated with the Risk of Esophageal Cancer

By Kyle J. Norton

Esophagus, an organ in vertebrates, is the tube that leads foods from the pharynx to the stomach.

Esophageal cancer is a medical condition caused by cell growth disorderly and uncontrollably in the tissue of the esophagus due to the alternation of the cell DNA. 

More precisely, esophageal cancer can be a result of DNA alternation of the cells that line the upper part of the esophagus or glandular cells that line the lower part of the esophagus, connecting to the stomach.

At the advanced stage, most cases of esophageal cancer after penetrating the wall of the esophagus tend to spread to the lymph node around the bottom of the esophagus, stomach, and chest, then to the distant parts of the body.

According to the statistics provided by the American Cancer Society, in 2019, approximately 17,650 new esophageal cancer cases will be diagnosed, including 13,750 in men and 3,900 in women.

Also, in 2019, esophageal cancer will also cause the death of 16,080 Americans, including 13,020 in men and 3,060 in women.

The 5-year survival rate of people diagnosed in the local stage of esophageal cancer is 45%, much less than other cancer, including 100% of breast cancer.

Believe it or not, esophageal cancer is more common among men than among women. The lifetime risk of esophageal cancer in the US is 1 in 132 in men and about 1 in 455 in women.

Patients with esophageal cancer at the very early stage due to the very small size of the tumor are asymptomatic. However, at the advanced stage, esophageal cancer tends to travel a distance away to infect other healthy tissue and organ, leading to secondary metastasis.

The most common areas of metastasis of esophageal cancer are lymph node around the bottom of the esophagus, stomach, and chest.

On finding a potential plant that processes anti-malignant tumor, activity researchers investigated the association between vegetables and fruits consumption and risk of esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma (EAC), gastric cardia adenocarcinoma (GCA) and gastric noncardia adenocarcinoma (GNCA)

According to the Netherlands Cohort Study in 1986 consisting of 120,852 Dutch men and women aged 55-69 filled out a questionnaire on diet and other cancer risk factors and after 16.3 years of follow-up
* 101 ESCC, 144 EAC, 156 GCA, 460 GNCA cases were identified.

* Total vegetable consumption was nonsignificantly inversely associated with EAC and ESCC risk, but not with GCA and GNCA risk/

* There were significant inverse associations with raw vegetables and EAC risk [RR per 25 g/day: 0.81, 95% confidence interval (CI) 0.68-0.98], and Brassica vegetables and GCA risk (RR per 25 g/day: 0.72, 95% CI 0.54-0.95).

* Total fruit consumption was associated with a nonsignificantly decreased EAC risk. Citrus fruits were inversely associated with EAC and GCA risk (RRs for highest vs. lowest intake: 0.55, 95% CI 0.31-0.98 and 0.38, 95% CI 0.21-0.69, respectively).

* Particularly, current smokers, vegetables and possibly also fruits intake was inversely associated with ESCC and EAC risk.

Based on the evidence, scientists said, "Consumption of (specific groups of) vegetables and fruits may protect against subtypes of esophageal and gastric cancer:.

 

Taken altogether, vegetables and fruits may be considered functional foods for the prevention and treatment of esophageal cancer, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Vegetables and fruits consumption and risk of esophageal and gastric cancer subtypes in the Netherlands Cohort Study by Steevens J1, Schouten LJ, Goldbohm RA, van den Brandt PA. (PubMed)

Field mustard Kills Lung Cancer Cells in Vitro

By Kyle J. Norton

Cancer is a class of diseases caused by cell growth and multiplication disorderly and uncontrollably due to the alternation of the DNA.

After colonizing the entire tissues of the specific organ, the oversize tumor cell can travel a distance away from the originated site to invade other healthy tissues, via lymph or blood.

The most advanced stage of cancer may result in the death of the patients.

The lung is a vital organ of the human being, located near the backbone on either side of the heart with functions that inhale oxygen from the air then transport them to the bloodstream to nourish the body cells' need and to exhale carbon dioxide from the bloodstream.

Lung cancer is a condition of the abnormal growth of the cells in the lung's tissue. A most common form of primary lung cancer is derived from epithelial cells.

The exact cause of lung cancer is not identified. However, epidemiologically, smoking, second smoke, exposure to certain chemicals, family history, people who have lung disease and excessive drinking are some prevalent factors associated with lung cancer developing.

Current and past smoking account for most cases of lung cancer. The risk of developing lung cancer is about 23 times higher in male smokers compared to non-smokers, epidemiologically.

The most common glands and organs of lung cancer metastases are adrenal glands, bones, brain, and liver.

According to the statistics provided by the American cancer society, lung cancer accounts for 14% of all new cancers diagnosed in the US. In 2018, there were about 234,030 new cases of lung cancer (121,680 in men and 112,350 in women). Lung cancer also causes the death of 83,550 in men and 70,500 in women in the same year.

On finding a potential plant that processes anti-invasive tumor activity researchers compared the effects of an n-butanol subfraction of B. Rapa L. (BRBS) anti-tumor effect on A549 lung adenocarcinoma cell.

According to the experimental results,
* BRBS treatment in a dose- and time-dependent manner, significantly inhibited the proliferation of A549 cells.

* Furthermore, by activating the increased reactive oxygen species (ROS) production to induce cytotoxic effects, BRBS significantly induced cell cycle arrest and apoptosis in A549 cells.

* Moreover, the inhibition was also found to exhibit cancer cell mitochondrial dysfunction characterized by a reduction in mitochondrial membrane potential and the release of cytochrome c, which promoted caspase-3 and poly(ADP-ribose) polymerase processing.

* Additionally, BRBS significantly suppressed the migration of A549 cells in vitro.

Collectively, scientists wrote, "BRBS inhibited A549 cell proliferation through increased ROS production and the mitochondria-dependent apoptosis pathway. Consequently, BRBS might be a potential candidate for the treatment of lung cancer".

Taken altogether, field mustard may be considered a functional food for the prevention and treatment of lung cancer, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) N-Butanol Subfraction of Brassica Rapa L. Promotes Reactive Oxygen Species Production and Induces Apoptosis of A549 Lung Adenocarcinoma Cells via Mitochondria-Dependent Pathway by Aipire A1, Chen Q2, Cai S3, Li J4, Fu C5, Ying T6, Lu J7, Li J. (PubMed)