Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals : September 2017

Saturday, 30 September 2017

Food Therapy: Kidney beans May Induce Risk of Intestinal Atrophy

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The use of plants for healing purposes have been predated long before the existence of modern medicine. Herbal plants have formed a fundamental sources for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Intake of kidney beans may result in increased risk of the developed intestinal atrophy, the renowned institute study suggested.

Kidney beans with kidney shape, strong flavor and color of reddish brown in nature are often the excellent dietary selection with no cholesterol, but a good source of protein and minerals.

Intestinal atrophy is the abnormality of small intestine mucous membrane, caused by bacterial infection.

According to the University of Utrecht, animal fed with kidney bean induced mucosal atrophy microscopically causing atrophy and dissection of the intestinal villus in association with lengthen crypts with cells in increased mitotic activity in compared to than normal tissues.

In compared to controls, kidney bean intake significantly decreased the goblet cells in secrete gel-forming mucins, the major components of mucus but increased in the crypt region, a gland found in the intestinal epithelium lining of the small intestine and large intestine.

Dr. Kik MJ, the lead author of the study said, " feeding Phaseolus vulgaris beans reduced the digestive and absorptive capacity of the mucosa, resulting in weight loss and diarrhea in affected pigs".

In randomized study with mice fed to chow, elemental diet, elemental diet plus concanavalin-A and elemental diet plus phytohaemagglutinin groups, group fed phytohaemagglutinin showed a strong effect of chemical compound lectin in inducing cell proliferation in the small intestine and crypt fission of the middle and distal small intestine in compared to other groups.

The study also showed that phytohaemagglutinin with high amount of lectin also induced intestinal atrophy by affecting the gastric function and mobility through increased secretion of hormone in regulated gastric acid (HCl). In fact, the effects of lectins cause significant gastric trophy on the small intestine and colon may vary between different sites in the gastrointestinal tract.

In support to the above analysis, the Christian-Albrechts-Universität study
with 30 day old male rats pairfed for 10 days with lactalbumin as a control diet or lactalbumin plus PHA or purified soybean trypsin inhibitor (STI) as a positive control (42 mg/rat/day) with or without 20 micrograms of the cholecystokinin A (CCK-A) antagonist MK 329, also found that oral administration of phytohaemagglutinin (PHA) in rats dose dependently induces growth of the small intestine through significantly increased CCK plasma levels from 0.75 to 6.67 (SEM 2.23) compared with 2.3 (0.35) pM in the control group.

The result of phytohaemagglutinin (PHA) intake in exhibit the intestine atrophy may be attributed to the lectin levels in increased production of hormone cholecystokinin in stimulated additional release of bile into the intestine.

Taking together, intake of kidney bean should be taken with care with patients with digestive problems as level of lectin may induce intestinal atrophy.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Pathologic changes of the small intestinal mucosa of pigs after feeding Phaseolusvulgaris beans by Kik MJ1, Huisman J, van der Poel AF, Mouwen JM(PubMed)
(2) Lectins can reverse the dsstal intestinal atrophy associated with elemental diets in mice M by SASAKI*, A. J. FITZGERALD*, G. GRANT , M. A. GHATEIà, N. A. WRIGHT* & R. A. GOODLAD§(Wiley online Library)
(3) Red kidney bean lectin is a potent cholecystokinin releasing stimulus in the rat inducing pancreatic growth byK-H Herziga, S Bardoczc, G Grantc, R Nustedeb, U R Fölscha, A Pusztaic(BMJ Journals)

Food Therapy: Kidney Bean, the Natural Antioxidants Whole Food

Kidney bean is popular because of its kidney shape, strong flavor and color of reddish brown in nature, It is often an excellent dietary selection with no cholesterol, but a good source of protein and minerals.

According to the joint study lead by Nanchang University, kidney bean exhibited a strong antioxidant activities through the levels of total phenolics and flavonoids with respective values in compared to 0.25-3.79 mg gallic acid and 0.19-7.05 mg rutin found in analyzed chemical compounds assay.

In ultra-performance liquid chromatography with diode array detector (UPLC-DAD), kidney bean processed the antioxidant activity (AA) ranged from 1.568 ± 0.041 to 66.572 ± 3.197 mg and radicals inhibited by 50% (EC50)concentration.

The extracts of kidney also found to have a capability in inhibiting the proliferation of the human epithelial colorectal adenocarcinoma (Caco-2) cells, human breast cancer cells MCF-7, and A549 NSCLC cell line through its antioxidant effects.

Dr. Ombra MN, the lead author said, "Cultivars differed in composition and concentration of polyphenols including anthocyanins; cooking affected the antioxidant activity only marginally."

Further to the study to compare the antioxidant activity of two solvents, aqueous (70%) acetone and water, and the extracts in relation to their phenolic contents, researchers found that queous acetone (70%) extracted containing more than twice of phenolics from hulls exhibited significantly higher antioxidant and stronger inhibitory effect on both cyclooxygenases, COX-1 and COX-2, (in expression of inflammation and inflammation in gastrointestinal tract), than water in regulated inflammation.

Dr. Oomah BD the lead author in the compared study said, "antioxidant activity that were significantly affected by cultivar and extracting solvent".

Taking together, kidney beans exhibited a strong antioxidant effect through its procession of various phytochemical compounds, such as total phenolics and flavonoids, in regulated inflammation caused by free radicals and microbial invasion.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Nutrients, phytochemicals and antioxidant activities of 26 kidney bean cultivars by Kan L1, Nie S2, Hu J1, Wang S3, Cui SW4, Li Y1, Xu S1, Wu Y1, Wang J1, Bai Z1, Xie M1.(PubMed)
(2) Phenolic Composition and Antioxidant and Antiproliferative Activities of the Extracts of Twelve Common Bean (Phaseolus vulgaris L.) Endemic Ecotypes of Southern Italy before and after Cooking. by Ombra MN1, d'Acierno A1, Nazzaro F1, Riccardi R2, Spigno P2, Zaccardelli M3, Pane C3, Maione M1, Fratianni F1.(PubMed)
(3) Antioxidant and anti-inflammatory activities of bean ( Phaseolus vulgaris L.) hulls by Oomah BD1, Corbé A, Balasubramanian P.(PubMed)

Food Therapy: Kidney bean, the Whole Food in Reduced Risk and Treatment of Leukemia

Kidney bean is popular food, with kidney shape, strong flavor and color in reddish brown in nature, used often as an excellent dietary selection because of enormous health benefits with a good source of protein and minerals.

Leukemia is condition of abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system. Depending to the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.

Chemical compound purified from dried kidney beans, namely, 7.3-kDa antifungal peptide, used mainly for treatment of fungal overgrowth, showed to suppress the spread of leukemia L1210 cells with an half concentration of 5.2±0.4 µM and 7.6±0.6 µM, according to the China Agricultural University.

Dr. Ma DZ, the lead researcher said, "(the antifungal peptide isolated from dried Nepalese large red beans) exerted an antiproliferative action on L1210 leukemia cells with an an half concentration of high doses at 15 and 60 microM, respectively".

Other chemical compound, L-asparaginaseenzyme, isolated from Phaseolus vulgaris seeds also enhanced anti-proliferative effect on ALL cells according to the WST-8 cell viability assay kit.

Furthermore, treatment of L-asparaginaseenzyme also involved significant in induced early apoptosis in acute Lymphoblastic leukemia in test subjects jn vivo.

According to the joint study lead by the King Abdulaziz University, the efficacy of novel L-asparaginaseenzyme, isolated from Phaseolus vulgaris seeds (P-Asp) in mice study showed that mice treated with P-Asp had less distinct allergenic responses by immune system in expression of higher risk of carcinogens and reduced treatment effects.

There is no doubt that kidney beans may be a potential health benefit in targeting the risk of Leukemia in early stage and prevent the progression of the cancer through anti-proliferative and induced tumors cell death.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) An antifungal peptide with antiproliferative activity toward tumor cells from red kidney beans by Li M1, Wang H, Ng TB.(PubMed)
(2) A peptide with potent antifungal and antiproliferative activities from Nepalese large red beans by Ma DZ1, Wang HX, Ng TB.(PubMed)
(3) Trypsin isoinhibitors with antiproliferative activity toward leukemia cells from Phaseolus vulgaris cv "White Cloud Bean" by Sun J1, Wang H, Ng TB.(PubMed)
(4) Isolation and Characterization of a Phaseolus vulgaris Trypsin Inhibitor with Antiproliferative Activity on Leukemia and Lymphoma Cells by Li M1,2, Liu Q3, Cui Y4, Li D5, Wang H6, Ng TB7.(PubMed)

Thursday, 28 September 2017

Food Therapy: Black bean, the Functional Food In Reduced Risk and Treatment of Osteocarcinoma

According to the The Chinese University of Hong Kong, hemagglutinin isolated from an edible legume, namely black bean, showed an anti proliferative activity against tumor cell lines MG-63 and HepG2 but not the normal cell line.

Malignant osteocarcinoma cell treated with the phytochemical also exerted a significant effect in shrinking of tumor cells as well as inducing apoptosis.

The study also stated that hemagglutinin also induced cell death through interfering the first stage of tumor cell division in expression of protein, RNA, and DNA and inducing mitochondrial membrane depolarization in controlling plasma membrane of a muscle or nerve cell

Furthermore, the study also suggested that the efficacy of hemagglutinin in causing cell death may be attributed to the function of protein in increased regulation of pro inflammatory expressions.

Dr. Dan X, the lead author said, " a novel hemagglutinin from an edible legume (showed) a growth-inhibitory effect on osteocarcinoma and liver cancer cells" and " The hemagglutinating activity of this hemagglutinin was demonstrated to be ion dependent and stable over a wide range of temperature and pH values".

The findings suggested that black bean may be considered as functional food in improved bone health as well as reducing risk and treatment of osteocarcinoma, but further studies are necessary to confirm it's potency.

Sources
(1) Purification and Characterization of a Novel Hemagglutinin with Inhibitory Activity toward Osteocarcinoma Cells from Northeast China Black Beans by Dan X1, Wong JH1, Fang EF2, Chan FC3, Ng TB1(PubMed).

Food Therapy: Black Bean the Best on Ameliorated Oxidative Stress in Chronic Diseases

By Kyle J. Norton

People who turn to alternative medicine for treatment of diseases in avoidance of adverse effects induced by conventional medicine should be patient. In compared to herbal medicine; food therapy even takes longer than six months to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Black bean may be used as function food to counter the over expression of free radicals through improved antioxidant activity, a university study postulated.

Oxidative Stress is the imbalance between free radical and antioxidant expression.
Black bean, a small roughly ovoid legumes with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

According to the University of Illinois at Urbana-Champaign, the use of common bean peptides may contribute to reduced risk of complications associated to chronic diseases, including oxidative stress.

Proteins and synthesized pure peptides from Mexican black and Brazilian Carioca bean, all showed a significantly rate in reduced oxidative stress through over expression of antioxidant activity.

In a randomized, controlled, crossover trial, 12 adults with metabolic syndrome (MetS) consumed one of three meals (black bean (BB), fiber matched (FM), and antioxidant capacity matched (AM)) on three occasions, then blood of participants is collection before (fasting) and five hours postprandially, Oxidized LDL (oxLDL) showed a trend of declining observed after the Back Bean and antioxidant capacity matched meals at five hours compared to the FM group.

Dr. Reverri EJ, the lead author said" black beans with a typical Western-style meal attenuates postprandial insulin and moderately enhances postprandial antioxidant endpoints in adults with MetS, which could only be partly explained by fiber content and properties of antioxidant capacity".

In the compared black bean peel extract (BBPE), pomegranate peel extract (PPE) and a combination of the two (PPE + BBPE), on streptozotocin-induced diabetic mice study conducted by the Xuzhou Medical College, after 4 weeks of injection, researchers found that PPE, BBPE or PPE + BBPE, DM mice showed in some different degrees, a decrease in blood glucose, increases in insulin secretion and the pancreas weight index, and an increase in antioxidative activity.

The result indicated that mice treated with black bean or combination of black bean showed a significant in reduced levels of oxidative stress through enhanced antioxidant activities.

Taking together, black bean may have a potential used as therapeutic whole food therapy for treatment in reduced oxidative stress in chronic illness.

Sources
(1) Characterization of peptides from common bean protein isolates and their potential to inhibit markers of type-2 diabetes, hypertension and oxidative stress by Mojica L1,2, Luna-Vital DA1,3, González de Mejía E1.(PubMed)
(2) Black Beans, Fiber, and Antioxidant Capacity Pilot Study: Examination of Whole Foods vs. Functional Components on Postprandial Metabolic, Oxidative Stress, and Inflammation in Adults with Metabolic Syndrome by Reverri EJ1, Randolph JM2, Steinberg FM3, Kappagoda CT4, Edirisinghe I5, Burton-Freeman BM6,(PubMed)
(3) Extracts of black bean peel and pomegranate peel ameliorate oxidative stress-induced hyperglycemia in mice by Wang JY1, Zhu C1, Qian TW1, Guo H1, Wang DD1, Zhang F1, Yin X1.(PubMed)

Food Therapy: Black Bean, The Best Functional Food in Reduced Risk of CVD and Heart Complications in Diabetics

By Kyle J. Norton

People who turn to alternative medicine for treatment of disease in avoidance of adverse effects induced by conventional medicine should be patient. In compared to herbal medicine; food therapy even takes longer to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Black or common bean may be considered as function foods in attenuated risk of Cardivascular disease, a renowned institute postulated.

Cardiovascular disease is a condition of heart attack caused by block of blood in vessel as a result of narrowing and hardening of blood vessels.

Black bean, a small roughly ovoid legumes with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

According to the University of Colorado Colorado Springs, individuals who eat more bean in promoted less glycaemic stress (hyperglycaemia and hyperinsulinaemia) may have a reduced risk of CVD,

The study also addressed the importance of bean efficacy on glycaemic response and the impact of that relationship may have on the risk of developing diabetes and CVD.
In Sprague-Dawley rats model and C57Bl/6 mice induced obesity by a diet, both bean diet,groups showed a significant in reduced plasma total cholesterol and LDL-cholesterol without affecting HDL-cholesterol or total TAG in short-term. And bean-fed obese mice not only induced weight loss but also improved plasma lipid profile within a 12 d time frame in compared to other groups.

The weight loss and reduced levels of blood cholesterol in tested subjects provided a significant information of dried bean function in ameliorated risk of cardiovascular disease.

Other in the study of risk of development of cardiovascular complications in patients with diabetes, suggested that the imbalance between reactive oxygen species and antioxidant systems in patients with types 2 diabetes may be leading causes of heart complications involving high cardiac collagen content.

Therefor, increased intake of bean diet may play a prevalent role in reduced risk of CVD by increased total antioxidant activity and reduced the expression of hyperglycaemic state, catalase and superoxide dismutase activity and tissue damage caused by lipid peroxidation.

Dr. Oliveira RJ, the lead author said, "The phaseolamin treatment attenuated the collagen levels compared to non-treated diabetic rats. Thus, the short-term anti-hyperglycaemic effect of the phaseolamin treatment may prevent the initial changes caused by oxidative stress and the deposition of collagen, as well as reduce the incidence of heart complications".

Collectively, adding a bean portion in your diet daily may have a substantially reduced risk of heart disease and heart complications in diabetics, in comparison to people with typical American diet.

Author Biography

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Phaseolus beans: impact on glycaemic response and chronic disease risk in human subjects by Hutchins AM1, Winham DM, Thompson SV.(PubMed)
(2) Edible dry bean consumption (Phaseolus vulgaris L.) modulates cardiovascular risk factors and diet-induced obesity in rats and mice by Zhu Z1, Jiang W, Thompson HJ.(PubMed)
(3) Phaseolamin treatment prevents oxidative stress and collagen deposition in the hearts of streptozotocin-induced diabetic rats by Oliveira RJ1, de Oliveira VN, Deconte SR, Calábria LK, da Silva Moraes A, Espindola FS.(PubMed)

Food Therapy: Coffee and Coffee Caffeine Elevated and Ameliorated Menopause Symptoms Differently

By Kyle J. Norton

In compared to herbal medicine, food therapy even takes longer to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Menopause is a natural and biological progression of women at certain age. The reduced hormone levels of inaction of ovaries induced menstruation stop and a set of symptoms

Coffee, second to green tea, is a popular and social beverage all over the world, particular in the West, made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

A study conducted by a renowned institute suggested that coffee nd coffee caffeine may have potential effect in reduced severity of some menopause symptoms and elevation of others.

In a cross-sectional survey conducted using the Menopause Health Questionnaire, completed by 2,507 consecutive women with menopausal concerns at the Women's Health Clinic at Mayo Clinic (Rochester, MN) between July 25, 2005 and July 25, 2011, caffeine intake in participants showed a greater positive effect in expression of vasomotor symptom of menopause women in compared to non drinkers group.

Other, in a cross-sectional study of a community-based sample of 243 women with vasomotor symptoms to evaluate the menopause symptoms of hot flashes (HF) and night sweats (NS) in symptomatic middle-aged women, intake of coffee showed to elevate symptom of hot flashes (HF) and night sweats (NS) in compared to non drinkers.

And caffeine intake also is found as one of predictor in exhibited both hot flashes (HF) and night sweats (NS) in the same study group.

But in animal model, according to the behavioral tests and oxidative stress parameters in ovariectomized mice, caffeine intake also showed a significant in reduced symptoms of anxiety induced by oxidative stress.

Administration of low doses of caffeine, for a short period of time, may be a new therapeutic approach to modulate the oxidative stress and anxiety in menopause, the "Iuliu Hatieganu" University of Medicine and Pharmacy postulated.

Taking altogether, coffee and coffee caffeine may have a strong effect in reduced and elevated menopause symptoms, in types depending manner.

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Author biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Caffeine and menopausal symptoms: what is the association? by Faubion SS1, Sood R, Thielen JM, Shuster LT.(PubMed)
(2) Perceived control, lifestyle, health, socio-demographic factors and menopause: impact on hot flashes and night sweats by Pimenta F1, Leal I, Maroco J, Ramos C.(PubMed)
(3) Modulatory effects of caffeine on oxidative stress and anxiety-like behavior in ovariectomized rats by Caravan I1,1, Sevastre Berghian A1,1, Moldovan R1,1, Decea N1,1, Orasan R1,1, Filip GA1,1.(PubMed)

Food Therapy: Kidney bean, the Best Anti-cancer Healthy Whole Food

By Kyle J. Norton

Expectation of easing symptoms after a few days of herbal treatment, in most cases are ended with disappointment. Symptoms of the diseases can only be eased gradually, depending to stage of the treatment which directly addresses to the cause of the disease.

Kidney bean may have potential effects against irregular cell growth in the body, causing various types of cancer, a recent study proposed.

Kidney bean is popular food, with kidney shape, strong flavor and color in reddish brown in nature, used often as an excellent dietary selection because of enormous health benefits with a good source of protein and minerals.

Cancer, a group of diseases characterized by cells growing and multiplying disordered and uncontrollable in our body. At the late stage, cancer cells may travel a distance away from the original site to invase other tissues and organs.

According to the joint study lead by the Shenzhen University, chemical compound 60-kDa glucosamine binding lectin, white kidney bean lectin (WKBL), showed an efficacy in inhibited HepG2 activity in compared to MCF7 cells through induced anti proliferative and anti apoptotic activities.

The study also found that epithelial tumor cell lines ( HONE-1) also are inhibited by chemical compound lectin in activation of various extrinsic apoptosis pathway involved cell death.

Dr. Chan YS, the lead author said, " The (anti proliferative) activity could be reduced by addition of glucosamine, which occupies the binding sites of WKBL, indicating that carbohydrate binding is crucial for the activity".

Beside chemical compound 60-kDa glucosamine binding lectin, 64-kDa glucosamine-specific lectin isolated from brown kidney bean also exhibited antiproliferative activity against nubers of cell lines including human breast cancer (MCF7) cells, hepatoma (HepG2) cells and nasopharyngeal carcinoma (CNE1 and CNE2) cells with concentration of an inhibitor of 5.12 µM, 32.85 µM, 3.12 µM and 40.12 µM respectively after treatment for 24 hours.

Particularly in breast cancer cell line MCF7, formation of apoptotic bodies of the tumors are associated to apoptosis involved estrogen receptor(ER) stress and directed protein response.

Taking together, Kidney bean processed an anti cancer effects by exhibited anti proliferative and anti apoptotic activities against the early stage of development and progression of the cancer in various pathway. Please note that raw kidney beans are toxic.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) White kidney bean lectin exerts anti-proliferative and apoptotic effects on cancercells by Chan YS1, Xia L2, Ng TB3.(PubMed)
(2) Isolation of a glucosamine binding leguminous lectin with mitogenic activity towards splenocytes and anti-proliferative activity towards tumor cells by Chan YS1, Wong JH, Fang EF, Pan W, Ng TB.(PubMed)

Wednesday, 27 September 2017

Food Therapy: Kidney bean, The Natural Whole Food with Anti-Microbial Activities

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over laast 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Expectation of easing symptoms after a few days of herbal treatment, in most cases are ended with disappointment. Symptoms of the diseases can only be eased gradually, depending to stage of the treatment which directly addresses to the cause of the disease.

Recently study conducted by renowned institute suggested that oral administrated kidney bean may have a potential health benefits in reduced risk and treatment of microbial infection.

Kidney bean is popular because of its kidney shape, strong flavor and color of reddish brown in nature, It is often an excellent dietary selection with no cholesterol and good sources of protein and mineral.

According to the research article posted at the Journal of Microbial & Biochemical Technology, lectins isolated from kidney bean seed displayed a significant antifungal and anti bacteria activity on many straits of Staphylococcus aureus ATCC 6538, and Streptococcus mutants ATCC 25175, Pseudomonas aeruginosa ATCC 10145 and Klebsiella pneumonia and Candida albican.

The chemical compound lectins also manifested inhibitory effects on human immunodeficiency virus-1 reverse transcriptase of enzymes in catalyzed the formation of RNA from a DNA and alpha-glucosidase in lower the rate of glucose absorption.

Dr. Ye XY, the lead author in the study said, " It(Lectins) exerted a suppressive effect on growth of the fungal species Fusarium oxysporum, Coprinus comatus, and Rhizoctonia solani".

Other researchers suggested that the potency of kidney bean in exhibited anti microbial effect may be a result of its source of nondigestible fermentable components and phenolic compounds.

In healthy mice exposed to dextran sodium sulphate (DSS) (via drinking water, 2% DSS w/v, 7 days) induced colitis and fed with one of three isocaloric diets: basal diet control (BD), or BD supplemented with 20% cooked white (WK) or dark red kidney (DK) bean flour for 3 weeks, mice fed with both bean diets reduced, significantly disease severity, colonic damage and exerted increased mRNA expression of antimicrobial effects involved innate immunity and protected mucosa from insults through stabilizing the mucus layer and promoted healing of the epithelium and reduced proinflammatory cytokins demonstration.

Furthermore, cooked white (WK) or dark red kidney (DK) bean fed mice also enhanced microbial-derived SCFA metabolite production in regulated fermentation products, gut barrier integrity and the microbial defensive response .....

Taking together, Kidney beans ( Phaseolus) showed to process a strong anti-microbial effect in reduced infection and inflammation caused by straits of bacteria and fungi, especially in protected the digestive system against inflammation cause of colitis.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Antimicrobial Activities of Lectins Extracted from Some Cultivars of Phaseolus vulgaris by SeedsEinas Hamed El-S1, Magda Mahmoud Ibrahim El-A2and Mervat Mounir S1(Journal of Microbial & Biochemical Technology)
(2) White and dark kidney beans reduce colonic mucosal damage and inflammation in response to dextran sodium sulfate by Monk JM1, Zhang CP1, Wu W2, Zarepoor L1, Lu JT1, Liu R2, Pauls KP3, Wood GA4, Tsao R2, Robinson LE5, Power KA6.(PubMed)
(3) Isolation of a homodimeric lectin with antifungal and antiviral activities from red kidney bean (Phaseolus vulgaris) seeds by Ye XY1, Ng TB, Tsang PW, Wang J.(PubMed)

Food Therapy: Coffee and Coffee Caffeine Intake and Risk of Gallstone and Gallstone Diseases

By Kyle J. Norton

In compared to herbal medicine, food therapy even takes longer to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Epidemiological studies, linking coffee consumption in reduced risk of gallstone, but not gallstone disease have been contradictory.

Gallstone is a stone formed within the gallbladder out of bile components as a result of building up of undissolved cholesterol over a prolonged period of time.

Coffee, a popular and social beverage all over the world, particular in the West, made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

In the review of 174 cases of gallstones determined by ultrasonography, 104 cases of postcholecystectomy, and 6889 controls of normal gallbladder in the total of 7637 men received a health examination at four hospitals of the Self-Defense Forces (SDF) with 174 cases of prevalent gallstones, 50 had been aware of having gallstones, researchers found that coffee and coffee caffeine drinkers express a high risk of gallstone incidence in compared to non drinkers.

In these group of middle-aged Japanese men, the relative odds ratios of gallstone disease 1.7 for coffee consumption of five cups or more per day vs. no consumption and 2.2 for caffeine intake of 300 mg/day or more vs. less than 100 mg/day.

Obviously, these findings contradicted to other studies in support of risk of gallstone reduced by coffee and caffeine intake, including the study conducted by Harvard School of Public Health.

Other, in the review literature of database from PubMed and EMBASE of all published studies before June 2015 researchers at The First Affiliated Hospital of Zhengzhou University files the following results
1. Coffee intake regularly and daily had a significantly reduced risk of gallstone disease, in related females, but not in males. based on prospective studies.

2. For patients drinking one cup of coffee per day, the risk of of gallstone disease was 0.95
3. For patients drinking 2, 4 and 6 cups of coffee per day, the estimated RRs of gallstone disease reduced to 0.89 (95% CI, 0.79 to 0.99), 0.81 and .75 respectively.
4, Coffee intake showed a linear association to ameliorated risk of gallstone diseases.

Interestingly, in a cohort of 80,898 women age 34-59 years in 1980 who had no history of gallstone disease, during 20 years of follow-up, researchers filed the below results
1. Compared to non caffeine coffee drinkers women, the multivariate relative risks of gallstone disease with cholecystectomy in compared to consistent intake of caffeinated coffee (0, 1, 2-3, and > or =4 cups/day) were 1.0, 0.91, 0.78, and 0.72 respectively.
2. Coffee caffeine intake was inversely associated to risk of cholecystectomy.
3. Caffeine intake (< or =25, 26-100, 101-200, 201-400, 401-800, and >800 mg/day) is linearly associated to reduced risk of gallstone disease with multivariate relative ratio of 1.0, 1.03, 1.01, 0.94, 0.85, and 0.85 4. Decaffienated coffee was not associated with risk.

There is no doubt that the study addresses a significantly inverse association in reduced risk of gallstone disease among coffee drinkers linearly.

Taking altogether, the contradictory result may warrant a further study, before one can make a decision of the effect of coffee and coffee caffeine in concern of risk of gallstone, but not in the attnuated risk of symptomatic gallstone disease.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Lossu

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Relation of coffee, green tea, and caffeine intake to gallstone disease in middle-aged Japanese men by Ishizuk H1, Eguchi H, Oda T, Ogawa S, Nakagawa K, Honjo S, Kono S.(PubMed)
(2) Systematic review with meta-analysis: coffee consumption and the risk of gallstone disease by Zhang YP1, Li WQ1, Sun YL1, Zhu RT1, Wang WJ1.(PubMed)
(3) A prospective study of coffee consumption and the risk of symptomatic gallstone disease in men by Leitzmann MF1, Willett WC, Rimm EB, Stampfer MJ, Spiegelman D, Colditz GA, Giovannucci E.(PubMed)

Food Therapy: Black Bean, A Potent Chronic Diseases Functional Food

By Kyle J. Norton

People who turn to alternative medicine for treatment of disease in avoidance of adverse effects induced by conventional medicine should be patient. In compared to herbal medicine; food therapy even takes longer to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Intake black bean regularly may have a potential effect in attenuated risk and treatment of chronic diseases.

Chronic diseases, not prevented by vaccines or cured by medication are any diseases last over 3 months or more.

Black bean, a small roughly ovoid legumes with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

According to the University of Colorado Colorado Springs, the efficacy of legume in reduced chronic illness risk may be attributed to antioxidant phytochemical activities as well as other responses influenced the classification to types of diseases such as diabetes, CVD and cancer.

In protein and four synthesized pure peptides isolated Mexican black and Brazilian Carioca bean showed a potential and therapeutic effect in treating antidiabetic and antihypertensive mice regardless of their antioxidant capacity.

In fact, according to the Universidad Complutense de Madrid, types of carbohydrates found in black bean may be associated with a low glycemic response, low serum cholesterol levels, and a decrease of colon cancer risk factors as well as other forms of in chronic diseases such as diabetes type II and cardiovascular diseases.

Collectively, black bean reduced risk and treatment of chronic illness are the result of improved antioxidant status and other mechanisms, including reduction of glucose, triglycerides, total cholesterol, llower levels of LDL and Raised HDL as well as protecting pancreatic ß-cells, ...

Taking together, there is no doubt that black bean may be used as functional foods in attenuated risk and treatment of chronic disease, through antioxidant, anti inflammatory, anti profilerative, cardioprotective..... activities.

Biography

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Phaseolus beans: impact on glycaemic response and chronic disease risk in human subjects by Hutchins AM1, Winham DM, Thompson SV.(PubMed)
(2) Characterization of peptides from common bean protein isolates and their potential to inhibit markers of type-2 diabetes, hypertension and oxidative stress by Mojica L1,2, Luna-Vital DA1,3, González de Mejía E1.(PubMed)
(3) [Role of black bean Phaseolus vulgaris on the nutritional status of Guatemalan population].
[Article in Spanish]by Serrano J1, Goñi I.(PubMed)

Tuesday, 26 September 2017

Food Therapy: Coffee, A Potent Functional Food in Attenuated Risk of Metabolic Syndrome

By Kyle J. Norton

In compared to herbal medicine, food therapy even takes longer to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Metabolic Syndrome is a group of risk factors associated with the development of cardiovascular disease and type 2 diabetes, including high blood pressure, abnormal high blood cholesterol and triglyceride levels,.....

A joint study by respectable institutes suggested that intake of coffee and coffee caffeine daily and regularly may associate to attenuated risk of metabolic syndrome.

Coffee, second to green tea, is a popular and social beverage all over the world, particular in the West, made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

According to the searching of database from f PubMed and the China National Knowledge Infrastructure (CNKI) for relevant articles published between 1 January 1999 and 31 May 2015, including 11 published reports and 13 studies with a total of 159,805 participants were eligible for our meta-analysis, the relative odd risk ratio of metabolic syndrome between the highest vs lowest category of coffee consumption was 0.872

The review also observed a non linear relationship between coffee and coffee caffeine consumption in ameliorated risk of metabolic syndrome, by dose-response analysis.

Additionally, in a cross-sectional population-based survey of 8,821 adults (51.4% female) conducted in Krakow, Poland. to evaluate the coffee and tea consumption and risk of metabolic syndrome, using food frequency questionnaires, observation of the questionnaire returned from participants expressed an interesting association between high coffee consumption of 3 cups and the clusters of lower BMI, waist circumference, systolic and diastolic blood pressure, triglycerides, and higher HDL cholesterol than those drinking less than 1 cup/day.

The study apparently indicated that people drinking 3 cups of coffee daily and regularly have a favorably ameliorated risk of metabolic syndrome even after adjusting for potential confounding factors.

More importantly, the study also pointed out that high coffee consumption was negatively associated with waist circumference, hypertension, and triglycerides in women but not in men.

Furthermore, in animal evaluation of the effect of coffee drinking on clinical markers of diabetes and metabolic syndrome in Zucker rats including Diabetic Zucker rats with metabolic syndrome and control Zucker rats, researchers at the Fluminense Federal Institute postulated that after animals received daily doses of coffee drink by gavage for 30 days, coffee consumption expressed a decreased risk of metabolic syndrome in reduced serum glucose, total cholesterol and triglycerides in compared to non treatment group.

Dr. Abrahão SA, the lead researchers said, "The results demonstrate that treatment with roasted coffee drink, because of its hypoglycemic and hypolipidemic effect, is efficient in the protection of animals with metabolic syndrome and diabetes mellitus type 2".

The findings from above studies suggested that coffee and coffee caffeine drinking daily and regularly have a favorably profound effect in decreased risk of metabolic syndrome, particular in women.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Author Biopraphy
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Coffee consumption and risk of the metabolic syndrome: A meta-analysis by Shang F1, Li X1, Jiang X2.(PubMed)
(2) Association of daily coffee and tea consumption and metabolic syndrome: results from the Polish arm of the HAPIEE study by Grosso G1,2, Stepaniak U3, Micek A3, Topor-Mądry R3, Pikhart H4, Szafraniec K3, Pająk A3.(PubMed)

Food Therapy: Black Bean, The Best Functional Food for Hypertension

Black bean, a small roughly ovoid legume with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

According to the joint study lead by the University of Illinois at Urbana-Champaign, Mexican black bean isolated proteins peptidase-IV (DPP-IV), after pepsin/pancreatin digestion, showed a significant effect in reduced hypertension at dose with IC50 = 0.03-0.87 mg and dry weight and inhibited α-glucosidase, a protein related to early onset of diabetes, ranged from 36.3 to 50.1% mg-1 DW.

The efficacy of the anti hypertension of the black bean is attributed to the elevation of antioxidant capacity fighting against forming of reactive oxygen species (ROS), Dr. Mojica L, the lead author insisted.

In an article published at the Research Journal of Pharmaceutical, Biological and Chemical Sciences,
black bean crude extract decreased both systolic as well as diastolic BP in a dose-dependent manner (1-100 mg/kg).

The article also indicated that the fall of both pressure may be due to presence of phytochemicals saponin fraction and medicogenic acid glucoside in the crude extract.

Further more, azuki bean (Vigna angularis) seed coats (ABSC) with different color, containing high amount of polyphenols attenuated vascular oxidative stress and inflammation associated with hypertension in experiment of hypertensive rats (SHR) and control normotensive Wistar-Kyoto (WKY) rats.

More importantly, treated mice with azuki bean (Vigna angularis) seed coats (ABSC), suppressed the elevation of SBP throughout the treatment period of 8 weeks, by decreasing of NADPH pxidase in activated free radical expression and increasing antibody p47phox and Nox4 against radical formation through mRNA expression.

Dr. Mukai Y, the lead researcher said, " polyphenol-containing ABSC could attenuate vascular oxidative stress and inflammation during the progression of hypertension, and this may lead to an improvement in hypertension".

The findings suggested that black bean with various chemical constituents may be considered as a functional and integrated food for reduced hypertensive risk and treatment of high blood pressure.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Characterization of peptides from common bean protein isolates and their potential to inhibit markers of type-2 diabetes, hypertension and oxidative stress by Mojica L1,2, Luna-Vital DA1,3, González de Mejía E1.(PubMed)
(2) Comparative Review on Harmless Herbs with Allopathic Remedies As AntiHypertensive by Joshi UH*, Ganatra TH, Bhalodiya PN, Desai TR, Tirgar PR(Research Journal of Pharmaceutical, Biological and Chemical Sciences)
(3) Polyphenol-containing azuki bean (Vigna angularis) seed coats attenuate vascular oxidative stress and inflammation in spontaneously hypertensive rats by Mukai Y1, Sato S.(PubMed)

Monday, 25 September 2017

Food Therapy: Intake of Raw and Incompletely Cooked Kidney Bean May Induce Toxicity

By Kyle J. Norton

The use of plants for healing purposes has been predated long before the existence of modern medicine. Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Hemagglutinating lectin, a main component isolated from several varieties of kidney bean (Phaseolus vulgaris) may induce toxicity, affecting abnormal development of microvilli of tiny hairlike folds in the plasma membrane of the small intestine, a respectable institute study suggested.

In South Africa, dried red kidney beans are prohibited for cultivation or consumption because of the potential toxicity to humans. However, the toxicity levels of hemagglutinating lectins activity in uncooked and incompletely cooked kidney bean is not higher in compared to the other bean varieties sold in the regions.

Researchers, in the compared toxicity of uncooked red kidney bean and other dried bean found that toxic potentials and health risks associated with red kidney beans are similar to those of other dry beans already commercially available to South Africans. Therefore, red kidney should have a commercial preference as of other beans.

Kidney bean is popular food, with kidney shape, strong flavor and color in reddish brown in nature, used often as an excellent dietary selection because of its enormous health benefits with a good source of protein and minerals.

According to the recent advanced study, intake of raw kidney bean may cause lectin-induced disruption of intestinal in interference with the intermediate and final stages of nutrient break down in the gut.

Dr.Pusztai A, the lead author said, "In nitrogen balance studies it was found that rats ingesting pure bean lectins were in negative nitrogen balance" and "These nitrogen losses may have been partly the result of systemic effects, possibly caused by a selective uptake of lectins by the gut".

The poorly digested chemical compound actually disrupted borders cells and intestinal absorptive cells of duodenum.

Taking together, regardless to levels of toxicity of bean varieties, epidemiological studies agreed that consumption of fully cooked kidney bean provides many nutrients with numerous health benefits. but kidney beans should not be eaten as raw.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biogrphy
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) The nutritional toxicity of Phaseolus vulgaris lectins by Pusztai A, Clarke EM, King TP.(PubMed)
(2) Recent advances in the study of the nutritional toxicity of kidney bean (Phaseolusvulgaris) lectins in rats by Pusztai A, King TP, Clarke EM.(PubMed)
(3) Red kidney beans--to eat or not to eat? by Venter FS1, Thiel PG.(PubMed)

Food Therapy: Black Bean, The Best in Reduced Risk and Treatment of Liver Fibrosis Naturally

Black or common bean may be a potential function foods used for reduced risk and treatment of liver

fibrosis, a research institute supposed.

Black bean, a small roughly ovoid legumes with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

Liver fibrosis is a condition of excessive accumulation of extracellular collagen caused by abnormal liver response to injure.

According to the Tecnológico de Monterrey, School of Medicine, Basic Research Laboratory, oral administrated black bean extraxt exerted a significantly decreased type I and type IV collagen gene expression.

In an eight weeks of carbon tetrachloride (CCl4)induced liver injury in rat model, black bean extract of 70 mg/kg treatment showed a reduced hepatic fibrosis index by 18% compared to positive controls.

The study also indicated that the efficacy of black bean extract in ameliorated risk of liver fibrosis due to injure may be attributed to legume strong antifibrotic compounds in treatment of diseases with increase in inflammation and oxidative burst in their pathogenesis, including liver fibrosis.

Furthermore in the application of 0.1 g of crude biomass obtained from seed coats of Perla black bean dissolved in 400 mL of H2 O, and 100 g of NaCl added in liver injure mice model, back bean treatment group expressed evidence of improvement of pathological changes, including interstitial fibrosis, inflammatory infiltration, collagen deposition and steatosis in compared to normal group.

Histological analysis showed that the test group presented a significant reduction of collagen deposition of which exhibited a reduced risk of developed liver scaring in the recover phase.

The study also insisted that antioxidant effect against liver intoxication, a widely use laboratory application in induced lipid peroxidation and trichloromethyl radical (CCl3 ), to cause severe liver cell damage in animal model, may represent a new perspective in liver injury and fibrosis prevention, the researcher concluded.

Taking together, black bean, contains various phytochemicals, such as naringenin, Nacetylcysteine, vitamin E, sylimarin, quercetin in exhibited antioxidant activity, may be considered as a integrated form of diet therapy for reduced risk and treatment of liver fibrosis.

Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Black bean extract ameliorates liver fibrosis in rats with CCl4-induced injury by López-Reyes AG1, Arroyo-Curras N, Cano BG, Lara-Díaz VJ, Guajardo-Salinas GE, Islas JF, Morales-Oyarvide V, Morales-Garza LA, Galvez-Gastelum FJ, Grijalva G, Moreno-Cuevas JE.(PubMed)(Annals of Hepatology)

Sunday, 24 September 2017

Food Therapy: Kidney(Common) Bean, The Whole Food in Reduced Risk and Treatment of Colon Cancer

By Kyle J. Norton

The use of plants for healing purposes has been predated long before the existence of modern medicine. Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Intake of thoroughly cooked kidney bean may reduce risk and inhibit the progression of colon cancer, the recent study suggested.

According to the Hannam University Daedeok Valley Campus, Korean kidney bean husk extract, ameliorated risk of colon cancer through the ability in control the messenger initiated chemical reactions of intracellular signaling responsible for inducing antitumor activities in colon cancer cells.

The anti preoperative effect of the extract also exhibited the protein in resposible in inducing cell death by interfering phases of tumor cell cycle division.

Dr.Lee YK, the lead author in the study said, " the ability of carcinogenesis control by Korean kidney bean husk extract with high potency suggests its value as an antitumor agent in colon cancer therapy."

Further more, in the evaluated composition and chemopreventive effect of a polysaccharide extract (PE) from cooked common beans ( P. vulgaris L), including kidney bean, in Negro 8025 with azoxymethane (AOM) induced colon cancer, rats group fed with polysaccharide extract (PE) showed a significantly decreased clusters of abnormal tissues in the lining of the colon and rectum.

The study also insisted, the anti colon cancer activity can also be attributed to cell apoptostic expression and action of butyrate concentration found in the beans.

In support to the above differentiation, the Querétaro State University study concluded that the efficacy of common bean in treatment of colon cancer is a result of chemoprevention against aberrant crypt foci, clusters of abnormal tube-like glands in the lining of the colon and rectum through a combination of cell-cycle arrest in phase I and II.

Additionally, the study also suggested that through modulation of gene expression profiles in the colon tissue, non-digestible fraction (NDF) of cooked bean (cultivar Bayo Madero) may contribute to the chemoprotective effect on early-stage colon cancer.

Taking together, intake of kidney bean regularly may have a potential effect in reduced risk and treatment of early stage of colon cancer.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Kidney bean husk extracts exert antitumor effect by inducing apoptosis involving AMP-activated protein kinase signaling pathway by Lee YK1, Hwang JT, Lee MS, Kim YM, Park OJ.(PubMed)
(2) Composition and chemopreventive effect of polysaccharides from common beans(Phaseolus vulgaris L.) on azoxymethane-induced colon cancer by Feregrino-Pérez AA1, Berumen LC, García-Alcocer G, Guevara-Gonzalez RG, Ramos-Gomez M, Reynoso-Camacho R, Acosta-Gallegos JA, Loarca-Piña G.(PubMed)
(3) Non-digestible fraction of beans (Phaseolus vulgaris L.) modulates signalling pathway genes at an early stage of colon cancer in Sprague-Dawley rats by Haydé VC1, Ramón GG, Lorenzo GO, Dave OB, Rosalía RC, Paul W, Guadalupe LP.(PubMed)

Food Therapy: Kidney Bean, The Best Natural Weight Loss Functional Food

Kidney bean, one of the functional food and its supplement may have a profound effect on weight loss to benefit people of overweight and obese, the recent study suggested.

Kidney bean is popular because of its kidney shape, strong flavor and color that is reddish brown in nature, genus Phaseolus, belonging to the family Fabaceae. The bean is often an excellent dietary selection with no cholesterol, but a good source of protein and minerals.

According to the Medicus Research LLC, Food with a low glycemic index such as kidney bean consisted the ability to cause weight loss with doses of 500 to 3000 mg per day, in either a single dose or in divided doses in oral administration.

Dr. Barrett ML, the lead author said, "Experiments conducted incorporating Phase 2 into food(including kidney bean) and beverage products have found that it can be integrated into various products without losing activity or altering the appearance, texture or taste of the food" and " ...has the potential to induce weight loss and reduce spikes in blood sugar caused by carbohydrates through its alpha-amylase inhibiting activity".

Other studies showed that extracts of kidney beans (Phaseolus vulgaris)suppress appetite to induce weight loss in animal and human. The efficacy of the extract induced weight loss of obese subjects may be depended to doses intake without promoting toxicity.

The efficacy of weight loss effects is attributed to function of kidney beans in inhibition of protein enzymes in breaking down the bond in long starch or glycogen molecules, interfering hormone in regulation of release stored bile into the intestine and the central mechanism(s) in regulating appetite, food intake, and food palatability.

In animal study, standardized extracts of P. vulgaris and C. scolymus and their combination, expressed a significant control of appetite, food intake, and postprandial glycemia.

With all information collected, one can believe that Kidney Bean and Kidney Bean supplement may represent a successful example of translational research in the nutraceutical field for production of commercial benefit weight loss products.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) A proprietary alpha-amylase inhibitor from white bean (Phaseolus vulgaris): a review of clinical studies on weight loss and glycemic control by Barrett ML1, Udani JK.(PubMed)
(2) Reducing effect of a Phaseolus vulgaris dry extract on food intake, body weight, and glycemia in rats by Fantini N1, Cabras C, Lobina C, Colombo G, Gessa GL, Riva A, Donzelli F, Morazzoni P, Bombardelli E, Carai MA.(PubMed)
(3) Reducing effect of a combination of Phaseolus vulgaris and Cynara scolymus extracts on food intake and glycemia in rats by Loi B1, Fantini N, Colombo G, Gessa GL, Riva A, Bombardelli E, Morazzoni P, Carai MA.(PubMed)

Saturday, 23 September 2017

Food Therapy: Black Bean In Reduced Risk of CVD and Diabetes in Metabolic Syndrome Adults

Intake of black bean and other common bean may associate to ameliorated risk of metabolic syndrome induced type 2 diabetes and cardiovascular disease, a joint study of renowned institutes suggested.

Metabolic Syndrome is a group of risk factors associated with the development of cardiovascular disease and type 2 diabetes.
Black bean, a small roughly ovoid legume with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

In a pilot study consisted 12 men and women with metabolic syndrome randomly assigned to eat three standard meals in a crossover design on three different occasions that contained either no added fiber (control (NF)), extrinsic or added fiber (AF), or whole black beans as the source of intrinsic fiber (BN). 5 hours after meal intake, black bean injection group showed a remarkable improvement of blood glucose, insulin, cholecystokinin (CCK) and the GI hormones in compared to other groups.

Unfortunately, even with such results, black bean meal was not the meal of choice of tested adult in compared to NF meal which tended to result in more satisfaction.

Dr. Reverri EJ, the lead author said, "incorporating whole blackbeans into a meal has acute beneficial metabolic and GI hormone responses in adults with metabolic syndrome and are preferred over adding equivalent amounts of fiber from a supplement."

Other, in the study of 12 adults with metabolic syndrome (MetS) consumed one of three meals (black bean (BB), fiber matched (FM), and antioxidant capacity matched (AM)) on three occasions with included blood collection before (fasting) and five hours postprandially, black beam intake group showed an improvement of insulin resistance, antioxidant capacity, oxLDL and inhibited pro inflammatory expression against risk factor of metabolic syndrome in increased risk of diabetes and cardiovascular disease.

The study also suggested black bean group according to observed plasma antioxidant capacity may be less at beginning in compared to AM group, but at the end point, BB group showed a significant antioxidant levels in compared to other 2 groups.

The finding evidences suggested that black bean may be considered as a therapeutic functional food in reduced risk of metabolic syndrome which is an early indicator of onset of diabetes and cardiovascular disease.

Sources
(1) Assessing beans as a source of intrinsic fiber on satiety in men and women with metabolicsyndrome by Reverri EJ1, Randolph JM2, Kappagoda CT3, Park E4, Edirisinghe I5, Burton-Freeman BM6.(PubMed)
(2) Black Beans, Fiber, and Antioxidant Capacity Pilot Study: Examination of Whole Foods vs. Functional Components on Postprandial Metabolic, Oxidative Stress, and Inflammation in Adults with Metabolic Syndrome by Reverri EJ1, Randolph JM2, Steinberg FM3, Kappagoda CT4, Edirisinghe I5, Burton-Freeman BM6,7.(PubMed)

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