Piperine is a phytochemical alkaloid in the class of organosulfur compound, found abundantly in white and black pepper, long pepper, etc.
In picryl chloride (PC)-induced ear swelling in PC sensitized mice,
PN-ext exhibited its histamine release inhibitory activity, in vitro on
compound 48/80-induced histamine release from rat peritoneal mast cells.
Piperine (4.5 and 2.25 mg/kg) orally
administered 5 times a week for 8 weeks in a murine model of asthma,
showed an effectiveness in suppressed eosinophil infiltration, allergic
airway inflammation and airway hyperresponsiveness by suppression of
the production of interleukin-4, interleukin-5(white blood cells
expression), immunoglobulin E and histamine
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References
(1) Histamine release inhibitory activity of Piper nigrum leaf by Hirata
N, Naruto S, Inaba K, Itoh K, Tokunaga M, Iinuma M, Matsuda H.(PubMed)
(2) Piperine inhibits eosinophil
infiltration and airway hyperresponsiveness by suppressing T cell
activity and Th2 cytokine production in the ovalbumin-induced asthma
model by Kim SH, Lee YC.(PubMed)
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