Food Therapy - Button Mushroom and Colon cancer

Mushroom is a standard name of white button mushroom, the fleshy, spore-bearing fruiting body of a fungus produced above ground on soil or on its food source, It is a genus A. Muscaria and belong to the family Amanitaceae and has been cultivated in many cultures all over the world for foods and health benefits.
Nutrients1. Carbohydrates
2. Protein
3. Thiamine (Vitamin B1)
4. Riboflavin (Vitamin B2)
5. Niacin (Vitamin B3)
6. Pantothenic acid (Vitamin B5)
7. Calcium
8. Phosphorus
9. Potassium
10. Sodium
11. Selenium
12. Iron
13. Copper
14. Zinc
15. Etc.
Chemical constituents
Astraodorol, Psilocybin, Lectin, adustin, ribonuclease, nicotine, 2-hydroxy-4-methoxy-6-methylbenzoic acid, orsellinic acid, melleolide, ergosterol, genistein, daidzein, daucosterol, genistin, uracil and D-mannitol(a).
Button Mushroom and colon cancer
Bowel cancer also known as colorectal cancer, is defined as a condition of the abnormal proliferation of cells in the colon, rectum, or vermiform appendix. It is the third most commonly diagnosed cancer in developed countries, including US and Canada.
A. bisporus showed to inhibit colon cancer cell line through positively increased GPx-1 and GPx-2 gene expression and GPx-1 enzyme activity in rat colon, due to the presented selenium(1). the Methodist Research Institute, Indianapolis study showed a positive effect of A. bisporus in inhibition of colon cancer (HT-29, HCT-116) cells, through cell cycle arrest at G0/G1 phase(2) and reversibly inhibits cell proliferation occurred within 30 min of the lectin being bound to the cell surface(3).



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References
(a) [Chemical constituents from fungus Armillaria mellea]. by [Article in Chinese] by Yuan XL¹, Yan LH, Zhang QW, Wang ZM.(PubMed)
(1) Selenium-enriched Agaricus bisporus increases expression and activity of glutathione peroxidase-1 and expression of glutathione peroxidase-2 in rat colon by Maseko T¹, Howell K, Dunshea FR, Ng K.(PubMed)
(2) Pleurotus ostreatus inhibits proliferation of human breast and colon cancer cells through p53-dependent as well as p53-independent pathway by Jedinak A¹, Sliva D.(PubMed)
(3) Intracellular trafficking and release of intact edible mushroom lectin from HT29 human colon cancer cells Lu-Gang Yu¹, David G. Fernig² an Jonathan M. Rhodes (The Febs Journal)