Phytochemical Piperine and allergic effect

Piperine is a phytochemical alkaloid in the class of organosulfur compound, found abundantly in white and black pepper, long pepper, etc.

In picryl chloride (PC)-induced ear swelling in PC sensitized mice, PN-ext exhibited its histamine release inhibitory activity, in vitro on compound 48/80-induced histamine release from rat peritoneal mast cells. Piperine (4.5 and 2.25 mg/kg) orally administered 5 times a week for 8 weeks in a murine model of asthma, showed an effectiveness in suppressed eosinophil infiltration, allergic airway inflammation and airway hyperresponsiveness  by suppression of the production of interleukin-4, interleukin-5(white blood cells expression), immunoglobulin E and histamine



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References
(1) Histamine release inhibitory activity of Piper nigrum leaf by Hirata N, Naruto S, Inaba K, Itoh K, Tokunaga M, Iinuma M, Matsuda H.(PubMed)
(2) Piperine inhibits eosinophil infiltration and airway hyperresponsiveness by suppressing T cell activity and Th2 cytokine production in the ovalbumin-induced asthma model by Kim SH, Lee YC.(PubMed)