Healthy Food Eggplants, the Cardio-Protective Veggies, Scientists Find

By Kyle J. Norton

Scientists may have found a whole fruit or vegetable with the potential to treat cardiovascular disease with no side effects, some studies found.

Cardiovascular disease is a class of conditions associated with heart and blood vessels. Anything that affects the normal heart and blood vessel functioning is considered risk factors of the disease, including heart muscle, valves, or rhythm, and blockage of blood vessels.

According to the statistics, in the US, approximately, 610,000 people die of heart disease every year that's 1 in every 4 deaths. The disease is the leading cause of death for both men and women.

The causes of cardiovascular diseases are associated with the location that affects the functioning of the heart and blood vessels, including atherosclerosis is caused by the blockade of the blood vessel due to the accumulation of plaques in the arteries and arrhythmias caused by abnormal heart rhythms.

Epidemiological studies strongly suggested that the most common cardiovascular disease that affects mostly heart disease patients is coronary artery disease (CAD).

Coronary artery disease (CAD) is the most common form of heart disease caused by one or more of the coronary arteries becoming narrow or blocked.

Some researchers suggested that the widespread diagnosis of coronary artery disease (CAD) in the Western world probably is a result of the promotion of the Western diet over the last few decades.


A diet high in bad cholesterol salts sugar and carcinogens associated with the accumulation of plaques on the arteries has been found to be a culprit of the onset of coronary artery disease in many studies.


Dr. Oikonomou E, the lead author in the joint study led by the National and Kapodistrian University of Athens in the concerns of CAD widespread in the Western world launched an investigation to examine the independent predictive value of an unhealthy diet on the severity of coronary artery disease (CAD).

In the total of 188 symptomatic stable patients with CAD. Patients were categorized as having severe CAD or nonsevere CAD by coronary angiography.

Among several demographics and clinical characteristics, all patients were tested using a semiquantitative food frequency questionnaire.

By analyzing the 8 principal components in the 8 distinct dietary patterns found in the returned questionnaire, researchers found that The Western dietary pattern (increased intake of fat, red meat, and carbohydrates and minimal consumption of fruits and green leafy vegetables) was predictive of severe CAD (area under the curve: 0.73, 95% confidence intervals: 0.64-0.83, P < .001).


These results not only suggested that the Western not only causes the onset of the disease but also increased the risk of severity of coronary artery lesions in patients with stable CAD.

The doctors in the study wrote the final report, "the findings highlight the role of dietary patterns when estimating cardiovascular risk for the management of patients with CAD".

Eggplant is a species of S. melongena, belonging to the family Solanaceae and native to India.

The plant has been cultivated in southern and eastern Asia since prehistory. It is famous for its deep purple and the best eggplant can be found from August through October when it is in season.

The chemical constituents of eggplant include sterols (i.e. typical plant sterols, androstane, pregnane, and cholestane derivatives, steroidal alkaloids, and sapogenins), phytosterols, triterpenes, δ-amyrin, Chlorogenic acid, Nasunin, and other Polyphenolic compounds.

In the finding, a natural compound with the efficacy for the prevention and treatment of cardiovascular disease with no side effects, researchers at the University of Connecticut School of Medicine examine the role of raw and grilled eggplants on cardioprotection using an isolated perfusion heart model.


The animals were fed freeze-dried products of either raw or grilled eggplants for 30 days. After 30 days, isolated working hearts were subjected to 30 min ischemia followed by 2 h of reperfusion.

The medical assays suggested eggplants process potent cardioprotective compounds judging by their ability to increase left ventricular function, and reduce myocardial infarct size and cardiomyocyte apoptosis.

Interestingly, researchers found no difference in cardioprotective ability between the raw and grilled products.

Based on the antioxidant vitamins classification, researchers showed that vitamin A, vitamin C, and β-carotene, were lower and some of the polyphenolic components, especially nasunin content, were higher in grilled eggplants, These results indicated that there must be some other ingredient processed by both grill and raw eggplants that exert cardiovascular diseases not found in this study.


Moreover, in the study to analyze total phenolics and antioxidant capacity in the indigenous vegetables for cardioprotective effect researchers at the Tuskegee University conducted a group analysis including collard greens, mustard greens, kale, okra, green onion, butter beans, butter peas, purple hull peas, rutabagas, and eggplant.

At a concentration of 10.0 mg dried vegetable equivalent/ml, the extract of these vegetables exerted a significant antioxidant activity by reducing 13.2-88.5% DPPH(•) radical in 30 min.

The Oxygen Radical Absorbance Capacity. (ORAC) value ranged from 2.5 to 100.7 µmoles of Trolox equivalents per gram of dried sample.

The antioxidant capacity of the vegetable samples was highly related to their total phenolic content.

The evidence suggested these indigenous vegetables are good sources of phenolic compounds, which might provide anti-oxidative protection against free radicals in inducing chronic diseases, such as cardiovascular disease.

Taken altogether, eggplant processed abundantly bioactive antioxidants may be considered a functional vegetable for the prevention and an adjunct therapy combined with the primary medicine for the treatment of cardiovascular disease without inducing any adverse effects

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cardioprotective properties of raw and cooked eggplant (Solanum melongena L) by Das S1, Raychaudhuri U, Falchi M, Bertelli A, Braga PC, Das DK. (PubMed)
(2) Total phenolics and antioxidant capacity of indigenous vegetables in the southeast United States: Alabama Collaboration for CardiovascularEquality Project by Huang Z1, Wang B, Eaves DH, Shikany JM, Pace RD. (PubMed)
(3) Western Dietary Pattern Is Associated With Severe Coronary Artery Disease by Oikonomou E1, Psaltopoulou T2, Georgiopoulos G1, Siasos G1,3, Kokkou E1, Antonopoulos A1, Vogiatzi G1, Tsalamandris S1, Gennimata V1, Papanikolaou A1, Tousoulis D. (PubMed)

Healthy Food Ginger May Process Anti Obesity Property, Researchers Say

By Kyle J Norton 

Ginger may be considered a functional food for the prevention and treatment of obesity without inducing side effects, some scientists found.

Obesity is a medical disease associated with extreme overweight.

In other words, obesity is the accumulation of excess fat to the extent that it may have an adverse effect on patient health.

According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered overweight, and a BMI of over 30 is an indication of obesity.

According to the statistic, 68% of the American population is either overweight or obese.

What causes obesity? Some researchers suggested that too much calories consumption and lack of physical exercise are the 2 main causes of obesity in once healthy individuals.

Some scientists indicated, there is no coincidence but a close correlation between the onset of obesity in a large percentage of Americans and the promotion of the Western diet in the past few decades.

Dr. Bortolin RC, the lead researcher in the obese team in the joint study led by the Instituto de Ciências Básicas da Saúde-Universidade Federal do Rio Grande do Sul (UFRGS in the examine the new animal diet based on human Western diet said, "Obesity is a metabolic disorder that predisposes patients to numerous diseases and has become a major global public health concern".


And, " diet, and not the obese state, was the major driving force behind gut microbiota changes. Moreover, the marked dysbiosis observed in CAF-fed rats might have resulted from the presence of several additives present in the CAF diet, or even a lack of essential vitamins and minerals".

These results strongly suggested that the Western diet alters the gut microbiota composition (dysbiosis) probably due to substances found in the Western diet foods, that are not found in other diets, compared to the group treated with HFD developed the greatest dysbiosis independent of obesity

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

On finding natural ingredients or whole food for the treatment of obesity researchers examine the traditional use of ginger in an animal model.

Application of ginger in vivo and vitro demonstrated a potential anti-obesity effect in regulating the PPARγ signaling pathway in adipocytes in the initiation of obesity,

Diet-induced obesity was attenuated in C57BL/6J mice treated with the dietary ginger extract (GE)also exhibited an increase in energy expenditure.



GE also exerted an anti-obesity effect through promoting the increased number of Types I muscle fibers, running endurance capacity, and upregulated PPARδ-targeted gene expression in skeletal muscle

Furthermore, the cellular respiration assay also revealed that pretreating cultured skeletal muscle myotubes with GE increased palmitate-induced oxygen consumption rate, which suggested an increase in cellular fatty acid catabolism, another anti-obesity activity.

After taking into account co and confounders, researchers said, "6-Shogaol and 6-gingerol (the ginger bioactive constituents)may be responsible for the regulatory effects of dietary ginger on PPARδ signaling".

Moreover, additional investigation of ginger exerts protective on obesity and its complications, researchers showed that gingerenone A, a bioactive compound isolated from ginger had the most potent inhibitory effect on adipogenesis and lipid accumulation in 3T3-L1 cells among ginger components at a single concentration (40 μM).

In vitro data, GA attenuates diet-induced obesity (DIO) by reducing fat mass in mice, accompanied by a modulation of fatty acid metabolism via activation of AMP-activated protein kinase (AMPK) in stimulating weight loss, in vitro and in vivo.

Dr.Suk S the lead author said in the final report, " GA may be used as a potential therapeutic candidate for the treatment of obesity and its complications by suppressing adipose expansion and inflammation".

Taken altogether, ginger processed abundant bioactive compounds may be considered a functional food in stimulating weight loss in obese subjects.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.





Sources
(1) Beneficial effects of ginger Zingiber officinale Roscoe on obesity and metabolic syndrome: a review by Wang J1,2, Ke W1, Bao R1, Hu X1,2, Chen F. (PubMed)
(2) Ginger extract prevents high-fat diet-induced obesity in mice via activation of the peroxisome proliferator-activated receptor δ pathway by Misawa K1, Hashizume K2, Yamamoto M3, Minegishi Y4, Hase T5, Shimotoyodome A. (PubMed)
(3) Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice by Suk S1, Kwon GT2, Lee E1, Jang WJ1, Yang H1, Kim JH3, Thimmegowda NR4, Chung MY1, Kwon JY5, Yang S1, Kim JK1,5, Park JHY2,3, Lee KW. (PubMed)
(4) A new animal diet based on human Western diet is a robust diet-induced obesity model: comparison to high-fat and cafeteria diets in term of metabolic and gut microbiota disruption by Bortolin RC1, Vargas AR1, Gasparotto J1, Chaves PR1, Schnorr CE1, Martinello KB2, Silveira AK1, Rabelo TK3, Gelain DP1, Moreira JCF. (PubMed)

Herbal Ashwagandha, the Best Antioxidant Functional Remedy

By Kyle J. Norton

Oxidative stress is a condition of imbalance of the ratio of antioxidants and free radicals in the body. In other words, the overproduction of free radicals accompanied by the decreased levels of antioxidants may cause cytotoxicity in the induction of oxidative stress.

Some researchers suggested long-term suppression by oxidative stress can activate the expression of over 500 different genes, including those for growth factors, inflammatory cytokines, chemokines, cell cycle regulatory molecules,...

Oxidative stress-activated inflammatory pathways have been found to induce the transformation of cell DNA to cause cancer and, chronic diseases.

Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.
Due to its nature to become stable, free radicals readily to donate or steal an electron from other molecules, leading to the chain of domino's effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.

This chain of reaction is the cause of oxidative stress, a condition is associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.

Antioxidants are stable atom that plays a critical role in protecting the body against the attack of free radicals.

In other words, antioxidants inhibited the onset of free radicals before they can cause a chain reaction in facilitating the protein, lipid, and cell DNA damage.

Antioxidants can either be produced by the liver or intake from dietary sources. Under normal conditions, antioxidant enzymes produced by the body in a healthy individual are good enough to counter the bombardment of free radical attacks.

However, in people with a weakened immune system, intake of dietary sources of antioxidants may be necessary.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound that processes the antioxidant activity, researchers investigated the effects of Withania somnifera on copper-induced lipid peroxidation and antioxidant enzymes in the aging spinal cord of Wistar rats.

According to the tested differentiation, the application of Withania somnifera exerted a strong effect on the levels glutathione peroxidase (GPx) which were decreased significantly in the spinal cord from adult to aged mice.

Withania somnifera also successfully inhibited lipid peroxidation in a dose-dependent manner through its antioxidant activity.

Furthermore, these effects were found to be similar to those of superoxide dismutase and mannitol.

Based on the findings, researchers said, "The results indicate the therapeutic potential of Withania somnifera in aging and copper-induced pathophysiological conditions".

Taken altogether, Ashwagandha may be considered a functional herb for the prevention of diseases associated with oxidative stress, pending the result of a larger sample size and multicenter study

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Withania somnifera (Ashwagandha) attenuates antioxidant defense in aged spinal cord and inhibits copper induced lipid peroxidation and protein oxidativemodifications by Gupta SK1, Dua A, Vohra BP. (PubMed)

Navy Bean, the Anti-Hypertension Health Food

By Kyle J. Norton

High blood pressure or hypertension is a medical condition characterized by abnormally high blood pressure in the arteries. High blood pressure is also a condition in the cluster of metabolic syndrome that increases the risk of heart disease, stroke, and diabetes.

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.

Although at the early stage, high blood pressure usually does not cause symptoms, some patients in extreme cases may experience dizziness and light head, shortness of breath, nosebleeds, flushing, chest pain, and visual changes.

Underlying medical conditions such as kidney disease and long-term stress are associated with high blood pressure.

More precisely, according to the American hypertension Association, long-term untreated high blood pressure can induce complications such as
* Heart attack is caused by damaged arteries due to high blood pressure that leads to blockage or limited blood flow to the heart muscle.

* Stroke, damaged blood vessels in the brain may be clogged and burst.


* Heart failure, high blood pressure increases the risk of enlarged-heart that limits the heart function in blood circulation


Conventional hypertensive medications have undoubtedly prevented many deaths from heart disease in the past 30 years, but they have many side effects.

If you currently taking hypertensive medicine, please make sure you know all the side effects of the preventive measure.

Some researchers also found that excessive energy intake and obesity are major causes of hypertension.

Dr. Savica V, the lead author in the study "The effect of nutrition on blood pressure" wrote, "Obesity is associated with increased activity of the renin-angiotensin-aldosterone and sympathetic nervous systems, possibly other mineralocorticoid activity, insulin resistance, salt-sensitive hypertension, and excess salt intake, and reduced kidney function".

High sodium chloride intake strongly predisposes to hypertension".

"Increased alcohol consumption may acutely elevate blood pressure. High intakes of potassium, polyunsaturated fatty acids, and protein, along with exercise and possibly vitamin D, may reduce blood pressure".


The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to its numerous health benefits.

With an aim to find a potential ingredient for the treatment of hypertension, researchers investigated the inhibitory activities of the navy bean by preparation of navy bean milk (NBM) subjected to fermentation of four lactic acid bacteria (LAB) strains, namely, Lactobacillus helveticus MB2-1, Lactobacillus plantarum B1-6, and Lactobacillus plantarum 70810.

According to the tested assays, all fermented NBM showed higher angiotensin I-converting enzyme (ACE) inhibitory activity compared to the unfermented ones.



By comparison of each strain, researchers found that 2 h, 3 h, and 5 h are the optimum fermentation periods for respectively L. plantarum 70810, L. plantarum B1-6 and L. bulgaricus.

Compared to the IC value without causing an intestinal disturbance, the extracts fermented by L. plantarum B1-6 exerted the lowest IC50 value of 21 ± 2.1 μg protein ml(-1).


Angiotensin-converting enzyme (ACE) is a central component of the renin-angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body.

In other words, the effect of LAB fermentation on the degradation of navy lean proteins and the capacity to release ACE inhibitory peptides may have a strong effect on the inhibition of hypertension.


Dr. Rui X, after taking other factors into account wrote, "The approach was promising to obtain probiotic products with the potential to serve as functional ingredients targeting hypertension".

Taken altogether, the fermented navy bean may be considered a remedy for the prevention and treatment of hypertension, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Enrichment of ACE inhibitory peptides in navy bean (Phaseolus vulgaris) using lactic acid bacteria by Rui X1, Wen D, Li W, Chen X, Jiang M, Dong M. (PubMed)
(2) The effect of nutrition on blood pressure by Savica V1, Bellinghieri G, Kopple JD(PubMed)

Omega-3 Fatty Acid Inhibits the Depressive Symptoms Regardless of Serum of Oxidated-LDL/LDL

By Kyle J. Norton

Depression is a normal response as part of our daily lives such as the loss of s job, the death of a loved one, and illness.

Over 30 million Americans suffer from depression and the amount is increasing at an alarming rate. Depression may be a mental health disorder that can affect the way you eat, sleep, and the way you feel about yourself. 

The mild case of depression can be defeated by a variety of self-care techniques. Others require the treatment of medication, such as antidepressant medications and psychotherapy that help to reduce and sometimes eliminate the symptoms of depression.

The most common depressive symptoms are feelings of helplessness and hopelessness, loss of interest in daily activities, appetite or weight changes, sleep changes, anger or irritability, reckless behavior and loss of concentration.

Cholesterol is a waxy substance that is produced either by the liver or injected from animal food sources.

Cholesterol found in our body is needed for our body to build cell walls, hormones, and vitamin D, and create bile salts that aid digestion. However, too much of them, in most cases due to the intake of animal protein can cause plaques built up on the arterial wall, the major cause of heart disease and stroke.

More precisely, if levels of low-density lipoprotein are high compared to high-density lipoprotein which returns the accessed cholesterol back to the liver, you have high blood cholesterol.

In other words, healthy blood cholesterol is any level with either less than or equal to 4 (low-density lipoprotein/ 1 (high-density lipoprotein).

According to the statistics, in 2015-2016, by age and gender, a total of 12.4 percent of adults aged 20 years and over had high cholesterol in the United States.

Lipoproteins are a general term of fat, cholesterol, and apolipoproteins, including the 2 most common forms of LDL (Low-Density Lipoprotein) and HDL (High-Density Lipoprotein).

Low-Density Lipoprotein is also known as bad cholesterol in the form of lipoprotein in which cholesterol is transported in the blood. High levels of low-density lipoprotein in the blood are associated with an increased risk of heart disease.

Lipoprotein ratio is the calculation of total/high-density lipoprotein (HDL) cholesterol and LDL/HDL cholesterol ratios which are considered indicators with greater predictive value than isolated parameters used independently in the prediction of the risk of heart disease.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of high blood cholesterol, researchers examined the effect of Omega 3 fatty acid on low-density lipoprotein on patients LDL with depression

The study included a total of 133 female workers in a hospital and nursing homes recruited in Japan.
According to the tested analysis, serum oxidated-LDL/LDL was positively connected with depressive symptoms but was more strongly related to perceived psychological stress.

Patients showed an increased serum of pro-inflammatory cytokine (IL-6)  partly transmitted via ox-LDL/LDL with a positive correlation with depressive symptoms.

Serum ω3 PUFAsfound in the blood were inversely associated with depressive symptoms independently of IL-6 or ox-LDL/LDL.

Taken altogether, Omega-3 fatty acids may be considered a functional food for the treatment of depressive symptoms regardless of the levels of the IL-6 or ox-LDL/LD, pending the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Serum IL-6 levels and oxidation rate of LDL cholesterol was related to depressive symptoms independent of omega-3 fatty acids among female hospital and nursing home workers in Japan by Tsuboi H1, Sakakibara H2, Tatsumi A3, Yamakawa-Kobayashi K4, Matsunaga M5, Kaneko H6, Shimoi K7. (PubMed)

Phytochemical Tocopherols Kill Glioma Cancer Cells in Vitro

By Kyle J. Norton


A glioma is a type of tumor that starts in the glial cells of the brain or the spine, comprising 30 percent of all brain tumors and central nervous system tumors.

Heterogeneous tumor cells of glioma are the type of cancer associated with genetic alterations that occur in individual tumors originating in the same organ.

Primary glioblastoma is considered the most aggressive cancer. Cancer may arise de novo, meaning they begin as a Grade IV malignant glioma tumor with no evidence.

Due to the rapid growth of the tumor, patients diagnosed with primary glioblastoma experience brain swelling and increased brain pressure, leading to symptoms of nausea, vomiting, and severe headaches and localized symptoms depending on the location of the tumor.

Radiation and chemotherapy are the most common forms of treatment for patients with glioblastoma particularly, in a tumor that cannot be removed with surgery.

According to the statistic, the median survival time of primary glioblastoma is approximately 3 months without medical treatment. Glioblastomas represent about 15% of all primary brain tumors.

Believe it or not, gliomas have been found accounting for 30 percent of all brain tumors and central nervous system tumors, and 80 percent of all malignant brain tumors.

Glioma can be classified into 3 types, including
* Astrocytomas are found in glial cells, star-shaped brain cells in the cerebrum called astrocytes. Most astrocytomas are localized.

* Ependymomas are cancers that grow in your brain or any part of the spine, including your neck and upper and lower back starting from the ependymal cells in the middle of your spinal cord and fluid-filled spaces in your brain.

* Oligodendrogliomas are cancers that begin on the oligodendrocytes of the brain or from a glial precursor cell.

The exact cause is unknown. Epidemiologically, age, exposure to radiation and family history are common risk factors that cause the onset of the disease,

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a most effective approach to glioma treatment, researchers examined the effects of a pH-sensitive core-shell nanoparticle (PDCP-NP) that targets the cancer stem cells (CSCs) and the differentiated tumor cells.

Where PDCP-NP is a cationic micellar core (Cur-M) that was first prepared from d-α-tocopherol-grafted-ε-polylysine polymer to encapsulate the hydrophobic curcumin, followed by dopamine-modified-poly-γ-glutamic acid polymer further deposited on its surface as an anion shell through pH-sensitive linkage to encapsulate the hydrophilic doxorubicin (DOX) hydrochloride with the control of the combinational Cur/DOX molar ratio at 3:1.

According to the analysis, PDCP-NP showed a ratiometric delivery capability to target cancer stem cells (CSCs) and the differentiated tumor cells in vitro and Vivo, compared to those of the cocktail Cur/DOX solution.

Treatment with PDCP-NP displayed a significantly decreased percentage of CSCs in tumors from 4.16% to 0.95%.

Based on the results, researchers said, " PDCP-NP may be a promising carrier for the combination therapy with drug candidates having dissimilar physicochemical properties".

Taken altogether, tocopherols used in a combination with other phytochemicals and chemo drugs may be considered an adjunct therapy for the treatment of glioma, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Ratiometric delivery of two therapeutic candidates with inherently dissimilar physicochemical property through pH-sensitive core-shell nanoparticles targeting the heterogeneous tumor cells of glioma by Xu HL1, Fan ZL1, ZhuGe DL1, Tong MQ1, Shen BX1, Lin MT1, Zhu QY1, Jin BH1, Sohawon Y2,3, Yao Q1, Zhao YZ. (PubMed)

Herbal Dandelion (Taraxacum officinale) Effects on Rheumatoid Arthritis (RA)

By Kyle J. Norton

Arthritis, one of the Musculoskeletal disorders (MSDs) degenerative disease, is a general term of joint inflammation, affecting over 21% of the US population.


There are over 100 different forms of arthritis and related diseases. Rheumatoid arthritis (RA), is the common form of arthritis involved in chronic low-grade inflammation.

Juvenile arthritis is an inflammatory disease affecting the synovium in children aged 16 or younger.

In other words, it is an autoimmune disorder caused by the immune system attacking some of the body's own healthy cells and tissues, in this case, the immune system attacks the joint tissue in the juvenile.

Genes that are associated with the risk of juvenile idiopathic arthritis include HLA-A. HLA-B. HLA-DPB1. HLA-DQA1. HLA-DQB1. HLA-DRB1. IL2RA. IL6, according to the National Institute of Health.

According to the statistic, the most common form of juvenile idiopathic arthritis (JIA), affects over 50,000 children in the United States alone.

Rheumatoid Arthritis (RA) is a type of arthritis associated with inflammation that affects mostly the flexible (synovial) joints and tissues and organs in the body.

The disease affects more women than men and generally occurs after the age of 40, causing the diminished quality of life of many older adults.

According to the CDC, musculoskeletal disorders (MSDs) affect over 52 million adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions.

Rheumatoid Arthritis can induce bone loss through elevating bone resorption without increasing bone formation.

A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes.


Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver, and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the treatment of chronic inflammatory diseases, scientists examined taraxasterol (TAR), a bioactive active compound pentacyclic triterpenes isolated from Chinese medicine herb Taraxacum officinale effects on rheumatoid arthritis (RA).

In Vitro and Vivo, the application of TRA significantly suppressed the proteins involved in the production of pro-inflammatory cytokines, namely tumor necrosis factor-α (TNF-α), IL-6, and IL-8 by blocking NOD-like receptor protein 3 (NLRP3) inflammasomes, activators of IL-1β secretion, particularly in the joints tissues of collagen-induced arthritis (CIA) mice.

Furthermore, the application of TRA also inhibited the enzymes involved in the productions of matrix metalloproteinases (MMPs), like MMP-1 and MMP-3 in HFLS-RA in vitro, degradation of the normal tissues.

Moreover, the injection of TRA also blocked nuclear factor kappa B (NF-κB) activation via modulating inhibitors of kappa B (IκB), IκB kinase (IKK) in the control of cytokines production and cell survival and transforming growth factor-β-activated kinase 1 (TAK1) to prevent the accumulation of ROS, resulting in cell death and inflammation.

Taken altogether, dandelion may be considered a remedy for the treatment of rheumatoid arthritis, pending the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Taraxasterol suppresses inflammation in IL-1β-induced rheumatoid arthritisfibroblast-like synoviocytes and rheumatoid arthritis progression in mice by Chen J1, Wu W2, Zhang M1, Chen C. (PubMed)