Scientists may have found a whole food which contains abundantly bioactive compounds for the prevention and treatment of leukemia with no side effects, some studies suggested.
Leukemia is a medical and chronic condition of abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system or the body's blood-forming tissues.
Depending on the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.
The causes of leukemia are unknown. However, most common risk factors associated with the onset of the disease include radiation exposure, treatment chemotherapy for cancer, smoking, family history of leukemia, and exposure to certain chemicals such as benzene.
Genetic preposition, according to some researchers, also plays a critical role in the prevalent risk of leukemia.
Dr. Nazanin Heidari, the lead scientist in the investigation of the genetic impact in the risk of leukemia wrote, "Epigenetic and genetic alterations are two mechanisms participating in leukemia, which can inactivate genes involved in leukemia pathogenesis or progression".
The team continued, inactivation of the genes ASPP1, TP53, IKZF1, and P15, have been correlated with poor prognosis in acute lymphoid leukemia (ALL), chronic lymphoid leukemia (CLL), chronic myelogenous leukemia (CML) and acute myeloid leukemia (AML), respectively. And abnormal genes specifically involved in leukemogenesis such as chromosomal translocations as well as genetic or epigenetic alterations, are involved in leukemogenesis.
Therefore, people who carry the mutated or inactive genes are at an increased risk of the condition.
Strawberry is a genius of Fragaria × ananassa belongs to the family Roseaceae. The fruits have been grown all over the world with a suitable climate for commercial profits and health benefits.
The major chemical compounds of strawberry include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin
In finding a natural ingredient or whole food for the prevention and treatment of leukemia (CEM), researchers at the Indian Institute of Science evaluated the consumption of berry fruits, including strawberries, against oxidative stress-mediated diseases.
In vivo, the methanolic extract of strawberry (MESB) fruits demonstrated a potential activity against leukemia (CEM) cell lines.
In mice models, the extract of the fruit also displayed cancer therapeutic and chemopreventive potential.
According to the tested assay, MESB induced cytotoxicity in cancer cells, irrespective of origin, through its antioxidant properties in a concentration- and time-dependent manner.
Furthermore, according to the results at the end of the experience, MESB treatment affected tumor cell proliferation by activating apoptosis with no side effects.
In-depth analysis of the effect of the extract, researchers found that MESB induces cancer cell apoptosis through enhancing the function of the tumor suppressor gene p70 in the intrinsic pathway of apoptosis bypassed the mutated tumor suppressor gene p53.
Dr. Somasagara RR, the lead author said, "Strawberry fruits possess both cancer preventive and therapeutic values".
Taken together, strawberries with the abundant bioactive compound may be considered a functional fruit for the prevention and treatment of leukemia (CEM) with no side effects.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Extracts of strawberry fruits induce intrinsic pathway of apoptosis in breast cancer cells and inhibits tumor progression in mice by Somasagara RR, Hegde M, Chiruvella KK, Musini A, Choudhary B, Raghavan SC. (PubMed)
(2) Significance of Inactivated Genes in Leukemia: Pathogenesis and Prognosis by Nazanin Heidari, M.Sc,1 Saeid Abroun, Ph.D.,Jessika Bertacchini, Ph.D,3 Tina Vosoughi, M.D,1 Fakher Rahim, Ph.D. and Najmaldin Saki, Ph.D. (PMC)
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