Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Monday 24 February 2020

Legume, the Natural Anti-Hypercholesterolemic Functional Food

By Kyle J. Norton

Hypercholesterolemia is a condition characterized by abnormally high levels of cholesterol in the bloodstream.

The cause of hypercholesterolemia is a result of overexpression of low-density lipoprotein with reduced levels of high-density lipoprotein in the blood.

In other words, the condition is a result caused by either overexpression of "bad" cholesterol (LDL) or low levels of "good" cholesterol (HDL).

Cholesterol, a waxy substance produced by the liver or the dietary in moderate amount source plays a critical to aid digestive function in absorbing nutrients, build strong cell membranes, produce steroid hormones and vitamin D. However, excessive amounts in the blood have been found to induce plaque built-up on the arterial wall, leading to heart disease and stroke.

Similar to high blood pressure, people with hypercholesterolemia are asymptomatic. Patients with familial hyper cholesterol may experience symptoms of chest pain with activity. xanthomas, and cholesterol deposits around the eyelids.

The most common complications associated with uncontrolled hypercholesterolemia are carotid artery disease, coronary heart disease, including angina or heart attack, peripheral artery disease, and stroke.

According to the statistics provided by the CDC, hypercholesterolemia is a major risk factor of heart disease, a leading cause of death in the US. In the US, approximately, 71 million American adults (33.5%) have high low-density lipoprotein (LDL), or “bad,” cholesterol, and only 1 out of every 3 adults with high LDL cholesterol has the condition under control.

Compared to hypercholesterolemia, the healthy levels of LDL/HDL are any numbers that are less than 4.

There is no single cause of hypercholesterolemia. Epidemiologically, diet, obesity, genetic preposition and medical conditions such as diseases such as type 2 diabetes and an underactive thyroid are some of the prevalent factors associated with the risk of the condition.

Legume is a class of fruits or seeds of a plant group in the family Fabaceae (or Leguminosae), cultivated all over the world as foods for commercial profits.

On finding a potent ingredient for the treatment of diseases associated with high blood cholesterols, researchers investigated the impact of potential health benefits of legumes as a good source of dietary fiber such as cowpeas, mung beans, pole sitao, chickpeas, green peas, groundnuts, pigeon peas, kidney beans, lima beans and soybeans against hypercholesterolemia.

According to the tested analysis,
* In vitro, the legume showed a good glycaemic index (GI) in non-diabetic and diabetic human subjects.

*The legume exerted a cholesterol-lowering effect in human subjects with moderately raised serum cholesterol levels.

* Kidney beans showed significant reductions for both total (6 %) and LDL-cholesterol (9 %), and groundnuts for total cholesterol (7 %; P < 0.05), compared to other types of legume.

Based on the findings, researchers concluded, "legumes are considered low-GI foods and have shown potential hypocholesterolemic effects. The above studies can be a scientific basis for considering legumes as functional foods".

Taken altogether, legume may be considered a functional food for the prevention of hypercholesterolemia, pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) The potential health benefits of legumes as a good source of dietary fibre by Trinidad TP1, Mallillin AC, Loyola AS, Sagum RS, Encabo RR. (PubMed)

Green Peas (Pisum Sativum), the Potential Anti Colitis Health Food

By Kyle J. Norton

Inflammatory bowel disease (IBD) refers to a set of disorders that involve chronic inflammation of your digestive tract, including the most common types such as

* Ulcerative colitis affects the innermost lining of your large intestine (colon) and rectum.

* Crohn's disease affects mostly the colon and the last part of the small intestine (ileum).

Colitis is a condition of inflammation of the large intestine, including the colon, caecum, and rectum.

There is no exact cause of colitis. Certain risk factors such as colon infection, inflammatory bowel disease (Crohn's disease, ulcerative colitis), ischemic colitis, allergic reactions, and microscopic colitis have been found to increase the risk of the condition.

The most common symptoms of colitis are totally depending on the types, including abdominal pain, cramping, diarrhea, with or without blood in the stool.

Conventionally, colitis caused by infection is treated by antibiotics. However, treatment of non-infection colitis is focusing on symptoms relief, supportive care, and maintaining adequate hydration and pain control.

The most common tools used for the colitis diagnosis are X-rays of the colon, testing the stool for blood and pus, sigmoidoscopy and colonoscopy.

The statistics provided by a study from the Medscape, suggested, "Internationally, the incidence of IBD is approximately 0.5-24.5 cases per 100,000 person-years for ulcerative colitis and 0.1-16 cases per 100,000 person-years for Crohn disease. Overall, the prevalence of IBD is 396 cases per 100,000 persons annually".

Green peas are species of Pisum Sativum belongings to the family Fabaceae and native to western Asia from the Mediterranean Sea to the Himalaya Mountains. The pea is a green, pod-shaped vegetable and a cool-season crop grown in many parts of the world.

On finding a potent ingredient for the treatment of diseases associated with a colonic inflammation, researchers investigated the impact of green pea (GP) supplementation on the susceptibility of high-fat diet (HFD)-fed mice to dextran sulfate sodium (DSS)-induced colitis.

The study included 6-week-old C57BL/6J female mice induced colitis was induced by adding 2.5% DSS in drinking water for 7 days followed by a 7-day recovery period that was fed a 45% HFD or HFD supplemented with 10% GP, after 7-week dietary supplementation.

According to the tested analysis, the administration of GP supplementation ameliorated the disease activity index score in HFD-fed mice during the recovery stage, and reduced neutrophil infiltration associated immune responses.

Furthermore, the production of pro-inflammatory cytokines involved in the mRNA expression of monocyte chemoattractant protein-1 (MCP-1) and inflammatory markers interleukin (IL)-6, cyclooxygenase-2 (COX-2), IL-17, interferon-γ (IFN-γ), and inducible nitric oxide synthase (iNOS) in HFD-fed mice was significantly decreased by the injection of GP.

Moreover, levels of mucin 2 produced from goblet cells in the epithelial lining into the lumen of the large intestine to protect the intestinal epithelium also increased in GP mice.

Additionally, GP ameliorated endoplasmic reticulum (ER) stress involved in the mediation of a pro-inflammatory synergy in the colon.

Based on the results, scientists said, " GP supplementation ameliorated the severity of DSS-induced colitis in HFD-fed mice, which was associated with the suppression of inflammation, mucin depletion, and ER stress in the colon".

Taken altogether, green peas may be considered a functional food for the prevention of colitis, pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) Dietary Green Pea Protects against DSS-Induced Colitis in Mice Challenged with High-Fat Diet by Shima Bibi, Luís Fernando de Sousa Moraes, Noelle Lebow, and Mei-Jun Zhu. (PMC)
(2) What is the global prevalence of inflammatory bowel disease (IBD)? by William A Rowe, MD; Chief Editor: BS Anand, MD. (Medscape)

Brassica Oleracea Vegetables Kills Colorectal cancer Cells in Vitro

By Kyle J. Norton

The colon-rectum formed a part of the digestive system is involved in the absorption of water from the small bowel contents and broken down certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.

Cancer is a class of diseases characterized by the irregular cell growth on the body tissue, due to the alternation of cell DNA.

Colorectal cancer is a medical condition caused by cell growth irregularly in the tissue of the colon or rectum due to the alternation of cells DNA.

According to the statistics provided by the American Cancer Society, in the US, colorectal cancer is the third most common cancer diagnosed in both men and women compared to other types of cancer.

The lifetime risk of colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.

Approximately, 140,000 cases of colorectal cancer were diagnosed in the US in 2018. Colorectal Cancer also causes the death of over 50, 000 people, representing 8.3% of total cancer death.

Being overweight or obese. smoking, physical inactivity, excessive alcohol drinking, the increase in age, family and personal history, genetic preposition are some of the prevalent risks of the disease.

Overall, the lifetime risk of colorectal cancer developing is 1 in 22 (4.49%) in men and 1 in 24 (4.15%) in women.

On finding a potential wholefood for the treatment of cancer, researchers examined the effect of principle bioactive compounds, isothiocyanates (ITCs) on a colorectal cancer cell line (HT-29).

According to the chemicals analysis, purple cabbage extract showed the highest ITC concentration per gram, fresh weight, followed by black cabbage and Romanesco cauliflower.

ITC at the concentrations of 7.08 microg/mL decreased cancer cell viability by inducing the caspase-3 associated with cell death and DNA fragmentation at 48h.

Brussels sprouts showed the strongest effects on cell viability and caspase-3 activity.

Furthermore, all varieties of Brassica Oleracea with rich sources of ITCs potently inhibit the growth of colon cancer cells by inducing apoptosis.

All the extracts showed anticancer activity at ITC concentrations of between 3.54 to 7.08 mug/mL,

Based on the finding, researchers said, " ITC concentration and the chemopreventive responses of plant extracts vary among the varieties of Brassica Oleracea studied and among their cultivars".

Taken altogether, Brassica Oleracea vegetables may be considered functional foods for the prevention and treatment of colorectal cancer, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Induction of apoptosis in HT-29 cells by extracts from isothiocyanates-rich varieties of Brassica oleracea by Mas S1, Crescenti A, Gassó P, Deulofeu R, Molina R, Ballesta A, Kensler TW, Lafuente A. (PubMed)

Sunday 23 February 2020

Lycopene, the Natural Antioxidants that Inhibits the Risk of Dyslipidemia

By Kyle J. Norton

Antioxidants are stable atoms that inhibit the oxidation caused by reactive oxygen species.

Antioxidants also play a critical role in the prevention of the oxidative stress induced by a chain of reaction as a result of over-expression of free radicals that can only be stopped with the expression of antioxidants produced by the host or from the dietary sources.

More precisely, oxidative stress is caused by the imbalance of the ratio of free radicals and antioxidants.

Epidemiologically, over time, oxidative stress induces damage of protein, lipid, and cell DNA that lead to the incidences of chronic disease, including heart disease, RA and cancers.

In cancer, antioxidants are molecules that process the capability to protect healthy cells against oxidative stress-induced DNA alternation.

In cardiovascular disease, antioxidants reduce the fragility and “permeability” in capillaries and prevent the clotting up of arteries due to oxidation.

In RA, antioxidant inhibits the rheumatoid joint fluid containing significant amounts of hydroxyl radical.

The overexpression of free radicals is bad. However, free radicals generated from cell metabolism may play a critical role in the synthesis of the energy of essential molecules and boosting the immune system. According to the free radical theory, over time, the damage inflicted by reactive oxygen species (ROS), can also induce skin aging.

In a healthy individual, antioxidant enzymes produced by the body are more than enough to accounter the expression of free radicals occurred in our body every day.

However, in people with a weakened immune system such as the elderly, the intake of dietary antioxidants such as supplements or fruits rich with antioxidants may be the only option to improve levels of antioxidants in the body.

Dyslipidemia is a condition with an abnormally high amount of lipids (e.g. triglycerides, cholesterol and/or fat phospholipids) in the blood.

Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

On finding a potential ingredient for the prevention and treatment of diseases associated with oxidative stress, researchers examined the effects of lycopene on vascular oxidative stress and inflammation in a young healthy subject.

The study included blood collection of 18 men and 9 women with restriction of lycopene-containing foods for 1-wk (LYr), after a fasting state and 3 h after an HFm and a low-fat meal (LFm).

Compared to the blood sample collected on pre- and post-meals following 1-wk of 80 mg/day lycopene supplementation (LYs) under continued dietary LYr in the fasting state, researchers found that

* LYs compared with LYr not only evoked a >2-fold increase in plasma lycopene but also increased plasma beta-carotene and alpha-tocopherol.

* However, LYs did not affect plasma nitrate/nitrite, a biomarker of nitric oxide, malondialdehyde, a biomarker of lipid oxidative stress, vascular- and intercellular-adhesion molecules or C-reactive protein, the biomarkers of inflammation.

In other words, HFm-induced dyslipidemic state was inhibited by LYr or LYs but did not affect the plasma malondialdehyde, C-reactive protein, or adhesion molecules.

The results suggested that 1-wk of LYs increased plasma lycopene, beta-carotene, and alpha-tocopherol do not have an effect on the plasma lipid-soluble antioxidant pool, biomarkers of vascular oxidative stress and inflammation in the fasted state as well as during dyslipidemia induced by an HFm in young healthy subjects.

In other words, plasma lycopene consumption inhibits dyslipidemia but does not affect the changes of parameters induced by an HFm in young healthy subjects in the short term.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The role of the antioxidants lycopene and vitamin E in the prevention of halothane-induced hepatotoxicity by Beştaş A1, Kahramanoglu M, Erhan OL, Bolat E, Ozercan I, Gürsu F, Gülcü F. (PubMed)
(2) Effect of short-term lycopene supplementation and postprandial dyslipidemia on plasma antioxidants and biomarkers of endothelial health in young, healthy individuals by Denniss SG1, Haffner TD, Kroetsch JT, Davidson SR, Rush JW, Hughson RL. (PubMed)

Non-soy Legume Inhibits the Over Expression of Serum Uric Acid that Causes Gout

By Kyle J. Norton

Uric acid, the form of ions and salts is a by-product of chemical after the body breaks down purines, the substance is found in many foods, including Asparagus, Bacon, Beef, Bluefish, Bouillon, Calf tongue, Carp, Cauliflower, Chicken, Chicken soup, Codfish, Crab, Duck, Goose, etc..

High levels of uric acid in blood serum can be harmful, leading to gout and forming of kidney stones.

Hyperuricemia is a condition of an excess of uric acid in the blood caused by reduced renal function.

The most common causes of hyperuricemia are genetics, insulin resistance, hypertension, hypothyroidism, obesity, diet, medications such as diuretics, and consumption of excess alcoholic beverages.

Gout mostly affected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in the blood, inducing joint inflammation.

The causes of gout are the result of high levels of uric acid in the body that can lead to the forming of crystals causes of inflammation due to your body can not get rid of uric acid or have made too much uric acid.

Reduced intake of meats and seafood and foods containing higher levels of uric acid, such as alcoholic beverages, especially beer, and drinks sweetened with fruit sugar (fructose) in patients with gout may be necessary.

According to the New York University School of Medicine/Langone Medical Center, the prevalence of gout and hyperuricemia has increased dramatically during the last several decades, to the point that gout is the most common inflammatory arthritis in the United States, affecting approximately 8 million Americans and contributing to great numbers of hypertension, chronic kidney disease, and cardiovascular disease.

The most common medication for the treatment of gout is Non-steroidal anti-inflammatory drugs (NSAIDs) by reducing pain and inflammation during an attack.

On finding a natural ingredient for the prevention and treatment of diseases associated with overexpression of purine, scientists examined the association between the consumption of non-soy legumes and different subtypes of non-soy legumes and serum uric acid (SUA) in elderly individuals with overweight or obesity and metabolic syndrome.

The cross-sectional analysis was conducted in the framework of the PREDIMED-Plus study that included 6329 participants with information on non-soy legume consumption and SUA levels

According to tested analysis,
* Individuals in the highest tertile (T3) of total non-soy legume, lentil, and pea consumption, had 0.14 mg/dL, 0.19 mg/dL, and 0.12 mg/dL lower SUA levels, respectively, compared to those in the lowest tertile (T1),

* Chickpea and dry bean consumption showed no association.

Based on the results, researchers suggest, "despite being a purine-rich food, non-soy legumes were inversely associated with SUA levels...prevalence".

Taken altogether, non-soy legumes may be considered functional foods for the treatment of diseases associated overexpression of serum uric acid (SUA), pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cross-sectional association between non-soy legume consumption, serum uric acid and hyperuricemia: the PREDIMED-Plus study by Becerra-Tomás N, Mena-Sánchez G, Díaz-López A, Martínez-González MÁ, Babio N, Corella D, Freixer G, Romaguera D, Vioque J, Alonso-Gómez ÁM, Wärnberg J, Martínez JA, Serra-Majem L, Estruch R, Fernández-García JC, Lapetra J, Pintó X, Tur JA, López-Miranda J, Bueno-Cavanillas A, Gaforio JJ, Matía-Martín P, Daimiel L, Martín-Sánchez V, Vidal J, Vázquez C, Ros E, Razquin C, Abellán Cano I, Sorli JV, Torres L, Morey M, Navarrete-Muñoz EM, Tojal Sierra L, Crespo-Oliva E, Zulet MÁ, Sanchez-Villegas A, Casas R, Bernal-Lopez MR, Santos-Lozano JM, Corbella E, Del Mar Bibiloni M, Ruiz-Canela M, Fernández-Carrión R, Quifer M, Prieto RM, Fernandez-Brufal N, Salaverria Lete I, Cenoz JC, Llimona R, Salas-Salvadó J; PREDIMED-Plus Investigators. (PubMed)

Green Bean Promotes Anti- Colon Cancer Activity in Vivo

By Kyle J. Norton

Cancer is a class of diseases characterized by cell growth irregularly in the tissue of specific organs.

Most cases of primary cancer start in the cells on the surface of the inner lining of specific tissues and organs, before penetrating into deeper layers to form a tumor.

At the advanced stage, the most malignant cancer cell can travel a distance away to infect other healthy tissues and organs, leading to secondary metastasis through blood and fluids circulation.

The colon formed a part of the digestive system is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.

Colon cancer is a chronic condition caused by irregular cell growth in the colon tissue. Most cases of colon cancer start with the alternation of cells DNA on the surface of the inner lining colon tissue before proliferating into deeper tissues to form a tumor.

Colon cancer is relatively very common, slowly growing and progressing cancer.

According to the statistics provided by the American Cancer Society, in 2019, colorectal cancer including colon and rectal cancer is the third most common cancer diagnosed in both men and women in the United States.

The lifetime risk of colon cancer developing is approximately 1 in 23 for men and women, inclduing 71% of colon and 29% of rectal cancer. Believe it or not, only 39% of colon patients are diagnosed with the localized-stage disease.

The exact causes of colon cancer are unknown. However, some researchers suggested the promotion of a high-fat diet over the past few decades may have a strong impact on the induction of colon cancer developing.

Dr. Milly Ryan-Harshman said, "Consumption of red meat might be related directly to the incidence of CRC or indirectly because a diet high in meat tends to be low in vegetables, fruit, and fiber".

And, "Evidence that diet has an effect on the incidence of CRC is only moderate and might be affected by the multifactorial nature of CRC. Making appropriate choices across food groups, particularly with respect to fruit, vegetables, and fiber, is the key to healthy eating".

Green bean is a genus of Phaseolus Sensu Stricto, containing 55 difference species, belong to the family Fabaceae and native to the New World tropics and grown in Europe for its attractive flowers and fleshy immature pods. It can be classified into two major groups, bush beans, and pole beans.

On finding a potent compound which processes chemopreventive activity, researchers examined BN999, a fermentation product of soybean, black bean, and green bean mixture in the inhibition the growth of human colon cancer.

Application of the mixed product showed a significant effect on inhibiting the growth of mouse CT-26 colon cancer xenografts from a patient's tumor that was implanted into syngenic BALB/c mice, without causing obvious side effects.

Furthermore, BN999 induced apoptosis in colon cancer cells without affecting the healthy cells.

Based on the findings, researchers after taking into account co and confounder wrote, "these data suggest that BN999 has the potential to be used as cancer chemoprevention or therapeutic agent".

Taken altogether, green beans used combined with fermentation product of soybean, the black bean may be used as an adjunct therapy for the prevention of colon cancer, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Fermentation product of soybean, black bean, and green bean mixture induces apoptosis in a wide variety of cancer cells by Chia JS1, Du JL, Wu MS, Hsu WB, Chiang CP, Sun A, Lu JJ, Wang WB. (PubMed)
(2) Diet and colorectal cancer. Review of the evidence by Milly Ryan-Harshman, Ph.D. RD and Walid Aldoori, MB BCh MPA ScD. (PMC)

Saturday 22 February 2020

Green Leafy Veggies Process Bile Acid Binding Activity

By Kyle J. Norton

Bile acids synthesized from by oxidation from cholesterol in the liver, flowing to the gallbladder to aid digestion.

Cholesterol is a waxy substance that is produced either by the liver or injected from animal food sources.

Cholesterol found in our body is needed for our body to build cell walls, hormones, and vitamin D, and create bile salts that aid digestion. However, too much of them, in most cases due to the intake of animal protein can cause plaques built up on the arterial wall, the major cause of heart disease and stroke.

Bile acid-binding is a process that interferes with normal fat digestion and absorption including the prevention of absorption of fat-soluble vitamins such as A, D, E, and K.

In other words, binding of bile acids (BAs) may have a strong effect to lower blood cholesterol levels by increasing the excretion of bile acids in the stool and reducing the amount of bile acid returning to the liver.

By inhibiting the levels of bile acid caused by a certain type of liver/bile duct disease such as partial biliary obstruction, levels of cholesterol can be controlled.

Conventionally, the effects of bile acid sequestrant are limited. Low doses of 8 gram/day of Cholestyramine, a bile acid sequestrant, which binds bile in the gastrointestinal tract to prevent its reabsorption can lower LDL cholesterol by 10%-15% compared to high doses of 24 gram/day of only 25%.

In other words, bile acid-binding medicine such as Cholestyramine, used alone are less effective, compared to statins in lowering LDL cholesterol.

The most common symptoms associated with the intake of Cholestyramine are constipation, diarrhea, stomach/abdominal pain, bloating, nausea, vomiting, and loss of appetite.

On finding a potential plant that processes anti-high blood cholesterol activity, researchers compared the bile acid-binding potential that lowers the risk of heart disease and cancer of various vegetables.

Compared to Cholestyramine (a cholesterol-lowering, bile acid-binding drug) that was used as the positive control treatment and cellulose as the negative control, researchers found that

* Relative to cholestyramine, in vitro bile acid binding on dry matter basis was for the collard greens, kale, and mustard greens, 13%; broccoli, 10%; Brussels sprouts and spinach, 8%; green bell pepper, 7%; and cabbage, 5%.

In other words, collard greens = kale = mustard greens showed the strongest healthy-promoting potential in bile acid-binding compared to the following lesser extent of > broccoli > Brussels sprouts = spinach = green bell pepper > cabbage.

More importantly, steam cooking significantly improved the in vitro bile acid binding of collard greens, kale, mustard greens, broccoli, green bell pepper, and cabbage compared to vegetables raw (uncooked).

More precisely, Inclusion of steam-cooked collard greens, kale, mustard greens, broccoli, green bell pepper, and cabbage in our daily diet may have the potential in improving the healthy levels of blood cholesterol.

Collectively, researchers said, "These green/leafy vegetables, when consumed regularly after steam cooking, would lower the risk of cardiovascular disease and cancer, advance human nutrition research, and improve public health".

Taken altogether, green leafy veggies may be considered functional foods for lowering blood cholesterol, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Steam cooking significantly improves in vitro bile acid binding of collard greens, kale, mustard greens, broccoli, green bell pepper, and cabbage by Kahlon TS1, Chiu MC, Chapman MH. (PubMed)