Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Sunday 26 August 2018

* Black Tea, The Beverage Which Alleviates Symptoms and Treats Irritable Bowel Syndrome

Kyle J. Norton

Black tea may have a therapeutic and positive effect in reduced risk and treatment of irritable bowel syndrome, some scientists suggested.

Black tea is a type of tea with more oxidized in compared to green tea, made from leaves of the shrub (or small tree) Camellia sinensis.

Irritable bowel syndrome is a common condition of digestive disorder, affecting the large intestine without inducing evidences of intestinal damage.

According to worldwide statistic, irritable bowel syndrome (IBS) is the most common functional gastrointestinal (GI) disorder, affecting approximately 10–15% general population.

Scientists as of today do not the exact causes of irritable bowel syndrome. However, some researchers suggested that some conditions such as abnormal gastrointestinal (GI) tract movements,..... and a disruption in neuro transmitted information to the GI tract are associated to increased risk of the disease.

Women who are less than 35 of age are more susceptible to the disease onset in compared to men.

Most common symptoms of IBS are long term gastrointestinal discomforts, including abdominal cramping or pain, bloating, gassiness,.... and altered bowel habits. Some women with IBS also experience symptoms worsened during periods and menstruation

If you have some symptoms above, you may have IBS. Please check with your doctor to rule out the possibility.

In the study of symptoms of gastrointestinal (GI) motility in patients with irritable bowel syndrome who exhibited reduced levels of serotonin 5-HT3 which play an important role in regulating the motility in the entire GI tract, researchers found that application of black tea and its major polyphenolic pigment thearubigins (TR) enhance movement of the gastrointestinal tract and stimulating gut emptying.

Additional assessment also discovered, black tea and its bioactive component also improved symptoms of diarrhea through promoting prokinetic activity with efficiency similar to those of conventional medicine benzoxazole.

Furthermore, in compared the efficacy of black tea extract and injection of ondansetron, a potent antagonist of 5-HT3 receptor used for treatment of nausea and vomiting caused by cancer chemotherapy, in IBS patients researchers indicated that black tea and its major polyphenolic pigment thearubigins (TR) demonstrated significant activity in reduced symptoms of IBS through mediation by the 5-HT3 receptors.

After taking into account of other con founders, researcher suggested, "black tea drinking in moderate concentrations and in proper amount could be useful to abate the GI consequences of IBS. In order to avoid gastro-esophageal reflux, it may be better to use decaffeinated tea".

Moreover, in the examine the tea flavonoids the large group of polyphenols in antioxidative and anti-inflammatory effects, scientists showed that application of epigallocathechin gallate and apigenin isolated from tea in IBS patients demonstrate an impressive activities in reduced expression of proinflammatory cytokines, such as interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-α, and IL-12, and lower levels of anti inflammatory mytokines IL-10 in the blood stream.

Truly, treatment of black tea also expressed a strong effect in reduced levels of plasma concentrations of malondialdehyde (MDA) and nitric oxide (NO) which are found elevated in patients with IBS, thus decreasing lipid peroxidation and alterations in the oxidant-antioxidant enzymatic system function in contribution of the pathogenesis of IBS.

The effect of antioxidant in reduced over expression of oxidative stress of black tea were attributed the strong effect of its chemical constituents in inhibited free radicals through stimulated the function of antioxidant in the tea and in the body natural antioxidant defense.
Therefore, the combination restored the ratio of reactive oxygen species and antioxidant produced by tissue in the body.

Dr, Hoensch H, the lead author at the Marienhospital Darmstadt.said, " Dietary supplementation with specific tea-flavonoids could be used for Crohn's disease, ulcerative colitis and irritable bowel syndrome".

Although, black tea showed a significant effect in inhibited irritable bowel syndrome, the geographic region where the tea were growth, the time of growth and harvested, how the tea is processed overall may contribute the increased or deceased efficacy of the beverage.

Taken together, black tea may be considered as functional food for reduced risk, inhibited symptoms and treatment of irritable bowel syndrome. However, intake of black tea extracts should be taken with extreme care, as acute liver toxicity was reported in some medical literature.

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Black tea extract and its major polyphenolic pigment may ameliorate the gastrointestinal disorder in irritable bowel syndrome by Jafari K, Faghihi M, Gharibzadeh S.
(2) [Anti-inflammatory effects of tea-flavonoids].[Article in German] by Hoensch H1, Oertel R.(PubMed)

Fennel, The Herb and Food Which Balances The Ratio of Gut Bacteria in the Digestive Tract For Optimal Health

Kyle J. Norton

Herbal fennel may have a substantial and potential effect in optimized gastrointestinal function by balancing the ratio of bacteria in the digestive tract, some scientists suggested.

Today, intake of high amount of process foods such as junk foods with high on saturate and trans fat, sugars, altered meats,... and salts in our diet have a significant and strong impact to throw gut bacteria off balance, the major cause of digestive disorder.

According to the CSIRO Food and Nutrition Flagship, "Gut microbes are capable of producing a vast range of products, the generation of which can be dependent on many factors, including nutrient availability and the luminal environment, particularly pH" and "particularly, many enzymes produced by microbes influence digestion and health"(4)

Our diet, particularly macronutrients, plays a major role in shaping the composition and activity of gut bacteria populations. Unhealthy diet can lead to short- and long-term imbalance of the good and bad bacteria.

Unhealthy life style such as smoking was found to increase Bacteroides-Prevotellain found in individuals with Crohn’s Disease (CD) and healthy individuals. Lack of exercise and increased environmental pollution associated with industrialization can significantly impact the large bowel microbiota population, leading to irritable bowel syndrome (IBD), CD,... and colorectal cancer (CRC)(4).

Dr. Conlon MA, the lead author said, "Inter-individual differences in populations of the gut microbiota may lead to different capacities to utilize dietary components and to different levels of disease risk. For example, some individuals have consistently low stool levels of the microbial fermentation product butyrate, levels which generally remain lower relative to others despite concentrations increasing in response to a diet high in resistant starch (RS)".

These results suggested that there is no one diet for all. Depending to each individual gastrointestinal needs, modified and change of diet may be necessary to achieve the balance of gut microbiota and improve digestive functions.

Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean.

The popular herb and food has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms,.....regulate the menstrual cycle and relieve PMS,...

In the examine the herbal extracts effect isolated fennel in inhibited the exertion of 15 gram-negative bacterium Helicobacter pylori (HP) in the gastrointestine tract, by compared to others including methanol extracts of Myristica fragrans (seed) of 12.5 microg/mL; Zingiber officinale (ginger rhizome/root) and Rosmarinus officinalis (rosemary leaf) of MIC of 25 microg/mL. researchers found that methanol extracts of botanicals with MIC of 50 microg/mL included Achillea millefolium, Foeniculum vulgare (seed), exert a significant effect in improved several aspects of digestive disorder by inhibited over expression of the gram negative HP in compared to other groups.

These results reaffirmed the use of the herbal fennel in traditional medicine for treatment of HP infections in induction of gastritis and peptic ulcer disease through stimulated immune response to activate cytokines to the site of infection and anti inflammatory activity in prevented over production of pro inflammatory factors that cause harm to the nearby healthy cells.

Furthermore, in the aim to find a natural substance for treatment functional dyspepsia (FD), a functional gastrointestinal disorder, with low cost and tolerated adverse effect, researchers at the joint study lead the Keio University, found that in rodent models, anethole, a bioactive compound isolated from fennel essential oil demonstrates a strong activity in improved clonidine-induced delayed gastric emptying but does not affect normal gastric emptying in mice.

Moreover, application of fennel oil and Anchu-san (a Japanese herbal medicine containing anethole) also restored fhe function of digestive system in delayed gastric emptying.

And, oral administration of anethole and fennel oil could be beneficial for the treatment of functional dyspepsia (FD. through theirs' sustainable effect in stimulated gastric accommodation

Functional dyspepsia (FD),is characterized by persistent or recurrent postprandial upper abdominal discomfort and epigastric pain.

Additionally, herbal formulation ColiMil (which contains Matricaria recutita flowers extract, Foeniculum vulgare fruit extract and Melissa officinalis aerial parts extract) has been used in herbal medicine to treat breastfed colic in infants,

Researchers at the University of Naples Federico II conducted a vivo study to reaffirm the viability of ColiMil in upper gastrointestinal transit in mice showed that oral injection of the herbal formulation at doses of 0.4-0.8 mL/mice delayed upper gastrointestinal transit in dose dependent manner.

Application of Foeniculum vulgare (8.21 and 16.42 mg/mouse) alone also reduced motility significantly but lesser in compared to herbal components, Matricaria recutita extract (0.89 and 1.78 mg/mouse) and Melissa officinalis extract (6.46 and 12.92 mg/mouse).

These findings suggested that ColiMil could be considered as a function herbal formula to improve colic in breastfed infants through reducing upper gastrointestinal motility.

Taken together, there is no doubt that fennel and its bioactive compound anethole may be considered as a function food to promote gastrointestinal function in absorption and distribution of nutrients and fluids to the body.

However, further data collection on large example size and multi centers studies performed with human consumption of the whole food during the course of disease will be necessary to complete the picture of fennel anti digestive disorder possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) In vitro susceptibility of Helicobacter pylori to botanical extracts used traditionally for the treatment of gastrointestinal disorders by Mahady GB1, Pendland SL, Stoia A, Hamill FA, Fabricant D, Dietz BM, Chadwick LR.(PubMed)
(2) Anethole restores delayed gastric emptying and impaired gastric accommodation in rodents by Asano T1, Aida S2, Suemasu S2, Mizushima T3.(PubMed)
(3) Effects of the herbal formulation ColiMil on upper gastrointestinal transit in mice in vivo by Capasso R1, Savino F, Capasso F.(PubMed)
(4) The impact of diet and lifestyle on gut microbiota and human health by Conlon MA1, Bird AR(PMC)

Cinnamon, The Miracle Remedy Which Processes Anti Type 2 Diabetes Potency

Kyle J. Norton. Master of Nutrition

The causes of type 2 diabetes are debatable as researchers do not know why some people are susceptible to develop insulin resistance while others do not.

However, genetics, unhealthy diet and lifestyle are the most common risk factors of type 2 diabetes(8).

Some researchers suggested that racial/ethnic group, overweight/obesity, elevated blood pressure, elevated casual blood glucose, and the presence of acanthosis nigricans) are associated to the development of type 2 diabetes mellitus (T2DM)(9).

If untreated, patients with type 2 diabetes may develop potential complications of heart disease.neuron, kidney, eye, foot, skin damage.

In some cases, these patients may be infected by plaques accumulated in neurons, leading to Alzheimer's disease.

According to 2015 statistic, in US, approximately 30.3 million Americans, or 9.4% of the population, had diabetes, including 1.25 million children and adults have type 1 diabetes.

Unfortunately, according of Center of Diseases Control (CDC), over 7.2 million people have diabetes but remain undiagnosed, while another 84.1 million adults 18 years and older have prediabetes.

Continuously, the CDC wrote, " The estimated diabetes cost in the United States in 2012 was $245 billion, including $176 billion for direct medical costs and $69 billion in indirect costs, such as disability, time lost from work, and premature death".

Cinnamon, a kitchen spicy in many cultures, may have gained many believers, including medical professions because of its anti diabetic effect, through regulating the blood glucose levels in healthy and diabetic subjects.

According to herbalists, intake of 1/4 tsp. in the morning and evening may reduce the blood sugar significantly with little or no adverse side effects.

The herb has been use in herbal and traditional medicine as anti-fungal and bacteria level to improve reproductive organ, prevent flatulence and intestinal cramping, treat indigestion, diarrhea, bad breath, headache, migraine, etc.(1).

In a total of 66 patients with type 2 diabetes study conducted by Xuhui District Central Hospital, researchers showed that cinnamon reduces significantly blood triglyceride levels even in the low-dose group, after 3 months of oral administration(2)

Its extract also improved fasting blood glucose levels and glucose tolerance without altering the insulin secretion, through lower triglyceride and increased liver glycogen content and improved insulin action in liver tissues(3).

Dr. Kim SH and Dr. Choung SY. told PubMed that “The effect of cinnamon in significantly increases insulin sensitivity, reduces serum, and hepatic lipids, and improves hyperglycemia and hyperlipidemia possibly by regulating the PPAR-medicated glucose and lipid metabolism”(4)

In support of the above, chromium(Cr) and polyphenols found in cinnamon(Cinnamomon cassia) in patients with type 2 diabetes expressed an strong improvement of glucose, insulin, cholesterol and HbA1c following Cr supplementation, in a double-blind placebo-controlled study(7).

Unfortunately, according to the Western University of Health Sciences, consumption of cinnamon is associated with a statistically significant decrease of levels of fasting plasma glucose, but insisted that high degree of heterogeneity may limit the ability to apply these results to patient care, due to the unclear preferred dose and duration of therapy(5)

The randomized clinical trial in which 70 Patients with type II diabetesassigned randomly two groups (35 in cinnamon and 35 in placebo group for the testing of the effect of cinnamon on the glucose level in blood, also indicated an insignificant effect of using cinnamon on glucose level of diabetic patients and the herb should not be recommended to patients with type II diabetes(6).

Taken altogether, cinnamon in low dose may be effective in controlling the levels of blood glucose in patient with diabetes without altering the insulin level. according to DR. Georgakopoulou EA(7).

Oral intake of Cinnamon may cause Stomatitis, and burning sensation in mouth with large amount. The traditional Chinese medicine also insisted that Overdoses of cinnamon can be toxic and damaged to liver(1).

Author biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

References
(1) @Popular Herbs -Cinnamon
(2) Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes by Lu T, Sheng H, Wu J, Cheng Y, Zhu J, Chen Y.(PubMed)
(3) Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity by Sartorius T1, Peter A2, Schulz N3, Drescher A2, Bergheim I4, Machann J5, Schick F6, Siegel-Axel D2, Schürmann A3, Weigert C1, Häring HU1, Hennige AM(PubMed)
(4) Antihyperglycemic and antihyperlipidemic action of Cinnamomi Cassiae (Cinnamon bark) extract in C57BL/Ks db/db mice by Kim SH1, Choung SY.(PubMed)
(5) Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis by Allen RW1, Schwartzman E, Baker WL, Coleman CI, Phung OJ.(PubMed)
(6) The Effect of Cinnamon on Glucose of Type II Diabetes Patients by Hasanzade F1, Toliat M2, Emami SA3, Emamimoghaadam Z(PubMed)
(7) Chromium and polyphenols from cinnamon improve insulin sensitivity by Anderson RA.(PubMed)
(8) Risk factors contributing to type 2 diabetes and recent advances in the treatment and prevention by Wu Y1, Ding Y1, Tanaka Y2, Zhang W(PubMed)
(9) The Presence of Risk Factors for Type 2 Diabetes Mellitus in Underserved Preschool Children by Montgomery M1, Johnson P2, Ewell P(PubMed)

Green Tea and Its Bioactive Epigallocatechin-3-gallate (EGCG) That Gobble Up Herpesvirus

Kyle J. Norton

Green tea may have a therapeutic and positive effect in inhibited herpesvirus, some scientists suggested.

Herpesvirus is a large family of DNA viruses that cause diseases depending to types of viral infection.

According to viral classification, there are 8 types of herpesvirus, including human herpesvirus 1 that causes cold sores around the mouth. and 2 that causes genital herpes, herpes zoster that causes chickenpox and shingles, Epstein-Barr virus that causes infectious mononucleosis, cytomegalovirus (CMV) that causes mononucleosis, Human herpesvirus 6 and 7(HHV6 - 7) that causes roseola and Human herpesvirus 8 (HHV8) that causes cancer, such as Kaposi's Sarcoma.

According to statistic, in the United States, half of teens and adults under age 50 are still infected with the oral herpes virus, and about 1 in 8 have an infection with the genital herpes virus.

All herpesviruses like other virus are nuclear-replicating, infecting healthy cells nucleus through replication of viral DNA and transcription of viral mRNA.

People infected by may experience symptoms.of painful sores in the genital area, anus, buttocks, thighs, itching, painful urination, vaginal discharge,..... and tender lumps in the groin.

However, some people may not show any symptoms at all and sometimes, the diseases may be misdiagnosed as a skin condition.

Sadly, many people have blisters and sores that come back after the first herpes attack goes away.

Green tea is a precious drink processed numbers of health benefit known to almost everyone in Asia and the Western world.

In the study of green tea Epigallocatechin gallate (EGCG bioactive component against researchers found that
EGCG and other purified green tea catechins as topical agents inactivate multiple clinical isolates of HSV-1 and HSV-2(1).

Application of EGCG in 10 to 20 min and reduced HSV-1 titers by the same amount in 30 to 40 min reduced HSV-2 titers by ≥1,000-fold(1).

Dr. Charles E, the lead scientists said, "(The efficacy in ameliorated risk of HSV), because EGCG would be able to directly inactivate extracellular HSV virions in the vaginal lumen" and " At a concentration range that can easily be delivered to the female reproductive tract".

Interestingly, in the study of Epigallocatechin-3-gallate (EGCG) effects on primary effusion lymphoma (PEL), an aggressive neoplasm caused by human herpesvirus 8 (HHV8), researchers found that EGCG inhibits induced cell death and ROS generation in PEL cells in a dose-dependent manner(2).

Furthermore, application of EGCG reduced the production of progeny virus from PEL cells without causing HHV8 reactivation(2).

These results suggest that EGCG may have a therapeutic treatment of HHV8 infection and HHV8 that cause lymphomas.

Most importantly, according to the joint study conducted by the Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, epigallocatechin-3-gallate (EGCG), processed significant anti-infective properties. EGCG exerted different modes of action in inhibited the diverse families of viruses(3)

In details(3), EGCG

* inhibited HCV through viral entry by interference with binding to target cells.
* Inhibited integrase, an enzyme produced by a retrovirus HCV by binding to envelope and CD4 and interference.
* Reduced HBV antigen expression, extracellular HBV DNA and cccDNA
* Induced damage and inactivation of virions of HSV-1/HSV-2, probably by binding to envelope proteins
* Inhibited EBV transcription of immediate-early genes Rta, Zta, and EA-D
* Inactivated Adenovirus particles, inhibited Adenovirus intracellular virus growth and viral protease
* Alternated influenza virus physical integrity of virus particles, inhibited entry by binding to haemagglutinin
* Suppressed enterovirus replication via modulation of cellular redox milieu

Taking all together, green tea and its bioactive constituents may be used in combined with conventional medicine for the prevention and treatment of herpesvirus.

However, further data collection on large example size and multi-centers studies performed with human consumption of the green tea and its bioactive polyphenol epigallocatechin 3-gallate (EGCG), during the course of herpesviral infection will be necessary to complete the picture of their anti herpesviral possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Epigallocatechin Gallate Inactivates Clinical Isolates of Herpes Simplex Virus by Charles E. Isaacs, Guang Y. Wen, Weimin Xu, Jun Hua Jia, Lisa Rohan, Christopher Corbo, Vincenzo Di Maggio, Edmund C. Jenkins, Jr., Sharon Hillier(PubMed)
(2) Epigallocatechin-3-Gallate Suppresses Human Herpesvirus 8 Replication and Induces ROS Leading to Apoptosis and Autophagy in Primary Effusion Lymphoma Cells by Tsai CY1, Chen CY2, Chiou YH3, Shyu HW4, Lin KH5, Chou MC6, Huang MH7, Wang YF(PubMed)
(3) Anti-infective properties of epigallocatechin-3-gallate (EGCG), a component of green tea by Steinmann J1, Buer J, Pietschmann T, Steinmann E(PubMed)

Saturday 25 August 2018

Green Tea Mixture (NM) Which Kills 100% of Hemangioendotheliomas Cells, Biomedical Literature Suggest

Kyle J. Norton, Master of Nutrition

Green tea may have a therapeutic and positive effect in reduced development of hemangiomas, some scientists suggested.

The results were carried out by some respectable intistutes including the Dr. Rath Research Institute and published on online medical literature.

Hemangioma is a benign tumor formed by a collection of excess blood vessels. The disease is a birth mark usually growth during the first year of life, and recedes over time.

Hemangioendotheliomas are chronic condition caused by abnormal growth of blood vessel cells, with no exact underlying cause. The disease is a rare vascular tumor, described for the first time in 1975 by Dail and Liebow as an aggressive bronchoalveolar cell carcinoma.

The disease most commonly affect the soft tissues, liver, lungs and bones.

Localized epithelioid hemangioendothelioma can be removed surgically.

Patients with hemangioendothelioma may induce symptoms weight loss. localized pain and swelling in the tumor area, red or blue skin nodules,..... and infectious organs enlargement.

If you experience some of above symptoms, please check with your doctor right the way to rule the possibility.

Green tea, is a precious drink processed numbers of health benefit known to almost everyone in Asia and Western world.

In differentiation of the efficacy of a nutrient mixture (NM) containing lysine, proline, ascorbic acid and green tea extract against the development of hemangiomas researchers at the Dr. Rath Research Institute, conducted a experiment using mouse in hemangioendothelioma model injected by Matrigel.

NM had shown a significant effect in inhibited hemangioendothelioma cell proliferation and cell division, in vitro through evaluating cell viability, MMP secretion, invasion, morphology and apoptosis.

Athymic nude mice, 5-6 weeks old, inoculated with 3 x10(6) EOMA cells subcutaneously and randomly divided into two groups,
* Group A was fed with a regular diet and
* Group B was fed with a regular diet supplemented with 0.5% NM.

At the end of the experiment, researchers found that mice fed with NM inhibits 50% of tumors growth.

Further analysis suggested that the efficacy of NM in inhibited the growth of tumor was attributed to its cytotoxicity linearly in induced apoptosis of EOMA cells, in dose dependent manner.

Injection of Matrigel in induction of tumor was inhibited by green tea mixture at 50, 100 and 500 microg/ml by 25%, 30% and 100% respectively

Dr. Roomi MW, the lead author, after taking into account of other co and con founders said, " NM may have therapeutic potential in treating infantile hemangioendotheliomas and, perhaps, other cutaneous vascular tumors".

Taken together, green tea mixture NM may have a profound effect in reduced risk and treatment of hemangioendotheliomas.

However, further data collection on large example size and multi centers studies performed with human consumption of green tea and its bioactive phytochemicals, during the course of the condition will be necessary to complete the picture of their anti hemangioendothelioma possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Antiangiogenic properties of a nutrient mixture in a model of hemangioma by Roomi MW1, Kalinovsky T, Niedzwiecki A, Rath M.(PubMed)

* 13 Health Benefits of Green Tea Bioactive Polyphenols Gallocatechin (GC), According to Medical Publication Online

By Kyle J. Norton

Green tea contains more amount of antioxidants than any drinks or foods with the same volume, and is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China.

Gallocatechin, containing catechin is phytochemicals of Flavan-3-ols, in the group of Flavonoids (polyphenols), found abundantly in green tea, almonds, black diamond plums, black tea, cocoa beans, Fuji apples, golden delicious apple, etc.

1. Bone metabolism
In the investigation of three tea catechins, epigallocatechin (EGC), gallocatechin (GC), and gallocatechin gallate (GCG) for their effects on bone metabolism, researchers found that EGC significantly inhibit osteoclast formations from RAW 264.7 cells upon receptor activation of nuclear factor-kappaB ligand induction on the fourth day of treatment, at a concentration of 10 microM(1).

Receptor activator of nuclear factor (NF-kappaB) ligand (RANKL) is the essential factor for osteoclast formation, fusion, activation, and survival, thus resulting in bone resorption and bone loss.

EGC also at dose-dependently inhibited the mRNA expression of tatrate-resistant acid phosphatase(1) which plays a critical role in many biological processes including skeletal development, collagen synthesis and degradation, the mineralisation of bone(14),
Further more, GC and GCG could decrease osteoclastogenesis at 20 microM.

Dr. Chun Hay Ko, the lead author said, "tea catechins, EGC in particular, had positive effects on bone metabolism through a double process of promoting osteoblastic activity(bone formation) and inhibiting osteoclast differentiation(bone re absorption)"(1).

2. Antimetastatic effects
In the evaluation of the antimetastatic effects of P urinaria L extracts (PUE), containing polyphenols including gallic acid, methyl gallate, epicatechin, epigallocatechin-3-gallate, gallocatechin-3-gallate, rutin, epicatechin-3-gallate, and naringin, researchers found that PUE inhibits the transcription of of MMP-2 osteoblasts that regulates osteopontin and bone protein expression in bone metastasis of osteotropic cancers(2).

Further more, PUE also exerted an inhibitory effect on the DNA-binding activity and the nuclear translocation of NF-κB and AP-1 in induction of secondary cancer and growth of LLC cells in vivo(2)

"(These results suggested that) PUE could be applied applied to be a potential antimetastatic agent", Dr. Tseng HH, the lead scientists at the Antai Tian-Sheng Memorial Hospital said(2).

3. Anti skin cancer
In the determination of the effect of green tea catechins on the invasive potential of human melanoma cells and the molecular mechanisms underlying these effects using A375 (BRAF-mutated) and Hs294t (Non-BRAF-mutated) melanoma cell lines in vitro model, researchers found that application of green tea catechins inhibits melanoma cell migration, through transition of mesenchymal stage to epithelial stage in induction of tumor growth to advanced stage(3).

These results indicate that EGCG, a major green tea catechin, has the ability to inhibit melanoma cell invasion/migration, an essential step of metastasis, by targeting endogenous expression of COX-2, which plays an important role in increased production of PGE2, the hormone that modulates skin caner cell proliferation from epithelial-to-mesenchymal transition(3).

4. Antidiabetic activity
In the observation of Terminalia sericea stem bark extract and theirs effect against alpha-glucosidase and alpha-amylase enzymes, four known compounds namely beta-sitosterol (1), beta-sitosterol-3-acetate (2), lupeol (3), and stigma-4-ene-3-one (4), in addition to two inseparable sets of mixtures of isomers [epicatechin-catechin (M1), and gallocatechin-epigallocatechin (M2). scientists found that 1 and 3 show the best inhibitory activity on alpha-glucosidase (IC50:54.5 and 66.5 microM) located in the brush border of the small intestine with function in stimulated digestion of carbohydrates that facilitates onset of diabetes mellitus type 2(4).

Bio-evaluation of the inhibitory activity of the purified compounds on alpha-amylase showed that 3 and 1 exhibit IC50 values of 140.7 and 216.02 microM, respectively against alpha-amylase, a protein enzyme that -links polysaccharides in induction of glucose and maltose with no side effects(4).

5. Anti-uveal melanoma and cancers activity
In the study of the new compound gallocatechin 5-O-gallate isolated to MeOH extract of Acacia nilotica pods, scientists found that the newly found compound exerts a significant effect in inhibited uveal melanoma, a cancer (melanoma) of the eye involving the iris(5).

Further more, the antiproliferative activities of the isolated compounds and the related compound epigallocatechin 3-O-gallate (EGCG) also have a profound effect in protected healthy cells against the development of cutaneous melanoma, ovarian cancer, glioblastoma and normal retinal pigmented cells(5).

6. Degenerative diseases
In the investigation of whether green tea and its components can regulate the osteogenic and adipogenic differentiation in pluripotent rat mesenchymal stem cells (MSCs)in MSCs isolated from the bone marrow of tibiae and femora in rat, researchers found that among six tested tea polyphenols, epigallocatechin (EGC) processes the most effective in promoting osteogenic differentiation.

At 20 μM, EGC increased ALP levels and Ca deposition significantly in promote bone denesity by 2.3- and 1.7-fold, respectively,

When compared with the control group. EGC also increased the mRNA expression of bone formation markers runt-related transcription factor 2, ALP, osteonectin, and osteopontin(6)

7. Antioxidants
In the identification of glucose-6-phosphate dehydrogenase (G6PD) and its important roles in the maintenance of cellular redox balance, researchers found that pretreatment with green tea polyphenol epigallocatechin-3-gallate (EGCG) effectively blocks peroxynitrite-induced glutathione depletion(antioxidant enzyme in the host), p53 accumulation in suppressed irregular cell growth and apoptosis in both normal and G6PD-deficient cells(7).

EGCG, administered to cells alone or as pretreatment, caused activation of protein kinase B (PKB), also known as Akt, that plays a key role in multiple cellular process in promoted survival and growth in response to extracellular signals.

The protective effect was abolished by phosphatidylinositol 3-kinase (PI3K) inhibitors, wortmannin, and LY294002, a steroid metabolite with function as immune suppressors(7).

8. Anti HIV
In the investigation of Epigallocatechin gallate (EGCG), the most abundant catechin in green tea and its effect on HIV-1, scientists found that EGCG appears to act mainly as an allosteric reverse transcriptase inhibitor with mechanisms different from those of currently approved NNRTIs used in the treatment of human immunodeficiency virus (HIV)(8).

Thus, EGCG is a good candidate for use as an additional or supportive anti-HIV agent derived from natural plants, according to "Epigallocatechin gallate inhibits the HIV reverse transcription step" by Li S, Hattori T, Kodama EN.(8)

9. Anti inflammatory activities
In the evaluation of the radioprotective efficacy of green tea polyphenols and the component ingredients against irradiated-induced damage in mice and elucidate the underlying mechanisms, researchers found that GTP and its bioactive components (catechin, epigallocatechin and epigallocatechin-3-gallate) assists in decreasing the leukocytopenia, disease that decreases number of white blood cells (leukocytes) found in the blood(9).

Injection of GTP and its bioactive components, significantly reduced the elevated serum inflammatory cytokines (TNF-α, IL-1β, and IL-6)(9).

These results suggested that green tea polyphenols have a potential to be developed as radioprotective agents against irradiated-induced toxicity(9).

Furthermore, the antioxidant and anti-inflammatory activities of GTP can be attributed to the interaction of the different components through multiple and synergistic mechanisms.

10. Anti microbial effects
In the evaluation of the anti-inflammatory and antimicrobial effect of nanocatechin on CBP and plasma concentration of catechins in an animal model, researchers showed that the use of ciprofloxacin, catechin, and nanocatechin statistically significant decrease in bacterial growth and improvement in prostatic inflammation compared with the control and catechin group..

Plasma concentrations of epicatechin, gallocatechingallate, and epigallocatechin gallate, were significantly higher in the nanocatechin group than those in the catechin group.

These results suggest that nanocatechin has better antimicrobial and anti-inflammatory effects on rat CBP than catechin due to higher absorption into the body(10).

11. Ultraviolet B irradiation protection
In the investigation of the protective effect of epigallocatechin gallate (EGCG) on the immune function of dendritic cells (DCs) after ultraviolet B irradiation (UVB), scientists found that the inhibition rate of DCs was improved to some extent after treatment with 200 microg/mL of EGCG.

UVB showed no significant influence on the secretion of IL-10 and IL-12 from DCs, while EGCG was able to down-regulate the secretion level of IL-12 and up-regulate that of IL-10.(11).

12. Antiviral effect
In the identification of tea polyphenols ability to inhibit enterovirus 71 (EV71) replication in Vero cell culture, researchers found that the viral inhibitory effect correlated well with the antioxidant capacity of polyphenol(12).

Mechanistically, EV71 infection led to increased oxidative stress, as shown by increased dichlorofluorescein and MitoSOX Red fluorescence(12).

Upon EGCG treatment, reactive oxygen species (ROS) generation was significantly reduced.

Consistent with this, EV71 replication was enhanced in glucose-6-phosphate dehydrogenase deficient cells, and such enhancement was largely reversed by EGCG(12).
.
13. Neuroprotective effect
In the research of beta-Amyloid (Abeta) peptide, a major component of senile plaques that play a crucial role in the development and neuropathogenesis of Alzheimer's disease (AD), researchers found that EGCG may have preventive and/or therapeutic potential in AD patients by augmenting cellular antioxidant defense capacity and attenuating Abeta-mediated oxidative and/or nitrosative cell death(13).

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources

* Carrot and Its Bioactive Chemical Compounds in Reduced Risk and Treatment of Colon Cancer

Kyle J. Norton, Master of Nutrition

Carrots may have a profound and positive effect in reduced risk, progression and treatment of colon cancer, some scientists suggested.

Colon cancer is a chronic condition characterized by irregular cell growth in the colon tissue. At the later stage, the cancerous cells may travel a distance away from the original site to infect other healthy tissue and organs.

As of today, researchers do not know what cause colon cancer. However, certain risk factors, such as genetic mutations that induce healthy DNA change are associated to increase risk of cancer.

Some researchers suggested that unhealthy diet and life style such as American diet with high intake of red meat, low intake of fiber, low intake of calcium, cigarette smoking,.... and obesity are the prevalent risk factors of colon cancer(4).

And increase consumption of a wide variety of fruit and vegetable, particularly, dark-green leafy, cruciferous, a deep-yellow on tones, and fibre are convincing preventive factors(5).

Dr. Corrêa Lima MP, the lead author at the Mato Grosso Federal University said, " lifestyle modification including proper diet such as the ones rich in vegetable and poor in red meat and fat, regular physical activity and maintaining an appropriate body weight and avoiding the use of tobacco and alcohol may lead to reduce colorectal cancer risk"(5).

Patients in early stage colon cancer may experience gastrointestinal symptoms of changes in your bowel habits, constipation. diarrhea or alternating diarrhea and constipation. Some patients may also develop symptoms of from rectal bleeding or blood in your stool, abdominal bloating,.... and cramps or discomfort.

Truly, some chronic conditions and medicine use for treatments also were found to increased risk of colon cancer, including diabetes, acromegaly, a growth hormone disorder, ,,, and radiation treatment for other cancers.

In US, colorectal cancer is the third most common cancer diagnosed in both men and women.

According to statistic of American Cancer Society, in 2018, approximately, 97,220 new cases of colon cancer.and 43,030 new cases of rectal cancer.are diagnosed in US. Colorectal cancer also causes death of 50,630 during 2018(6).

Carrot, a root vegetable with orange color is a sub spices of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

According to the study to determine the anticancer activity of the pentane fraction (F1) and the 1:1 pentane:diethyl ether fraction (F2) isolated from Daucus Carota oil extract (DCOE) against human colon adenocarcinoma cell lines (HT-29 and Caco-2), application of various concentration of both extracts exerted significant inhibitory effect against proliferation and induced apoptosis through numbers of factors.

The observation by Western blot revealed that the activity of F1 and F2 constrict the tumors expansion through activation of caspase-3, the key protein facilitators with function to execute apoptosis or program cell death and PARP cleavage, with function in stimulated various pathological cell death processes.

Further analysis also suggested that F1 and F2 inhibited the cell death processes through increased levels of Bax expression in initiated pro-apoptotsis involved in a wide variety of cellular activities and p53 in regulated cell cycle as a tumor suppressor.

Together, both injections also deceased levels of Bcl-2 with function in inhibited tumor cells apoptosis.

Moreover, treatment of HT-29 cells with either fraction markedly also induced cell adhesion, cell cycle progression, cell migration, cell apoptosis through decreased the levels of both phosphorylated Erk and Akt.

Activation of oncogenic signalling proteins AKT and ERK by phosphorylation has an established role in the development of certain types of cancer(7).

Additionally, in mice model, β-2-himachalen-6-ol (HC) isolated from the Daucus carota oil extract st the concentration of 1, 5, 10 and 25 μg/ml, were also found to inhibit numbers of cancers, including colon cell progression.

In SW1116 colon cancer cell lines, injection of β-2-himachalen-6-ol (HC) demonstrated a significantly inhibitory activity in a dose-dependent in decreased cell survival with an IC50 of 18 and 14.5 μg/ml after 24 and 48 h respectively.

According to the Flow cytometry analysis, at concentration of 10 μg/ml, HC increased the number of tumors cells undergoing necrosis of 18.05% and 58.01% and late apoptosis of 15.66% and 30.47%, respectively.

These results suggested that β-2-himachalen-6-ol (HC) induced cancer cell apoptosis and cancer growth restriction, linearly in doses dependent manner.

Additional differentiation also suggested the application exerted anti colon cancers cell line effect through similar proteins and pathways as mentioned in the first study.

Most importantly, β-2-himachalen-6-ol (HC) in inhibited colon cancer cell line through cytotoxicity in cell cycle arrested without causing harm to the nearby health cells.

The above illustration were also supported by the investigation of beta-carotene and lycopene, a bioactive phytochemical found in carrot in a modify luminal process relevant to colon carcinogenesis conducted by the Technical University of Munich.

According to the randomized cross-over trial of twenty-two healthy young men on a low-carotenoid diet consumed 330 ml tomato or carrot juice per d for 2 weeks, consumption of carrot juice led to a marked increase of beta-carotene and alpha-carotene in faecal water with high dose-dependent cytotoxic and anti-proliferative effects on colon adenocarcinoma cells (HT29).

Taken together, carrot and its bioactive compounds may be considered as function food in ameliorated risk and increased efficacy of conventional medicine for treatment of colon cancer.

However, further data collection on large example size and multi centers studies performed with human consumption of the carrot and its bioactive phytochemicals, during the course of the disease will be necessary to complete the picture of their anti colon cancer possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Daucus carota Pentane-Based Fractions Suppress Proliferation and Induce Apoptosis in Human Colon Adenocarcinoma HT-29 Cells by Inhibiting the MAPK and PI3K Pathways by Shebaby WN1, Bodman-Smith KB1, Mansour A2, Mroueh M3, Taleb RI4, El-Sibai M4, Daher CF4.(PubMed)
(2) Effects of carrot and tomato juice consumption on faecal markers relevant to coloncarcinogenesis in humans by Schnäbele K1, Briviba K, Bub A, Roser S, Pool-Zobel BL, Rechkemmer G.(PubMed)

(3) Antitumor activity of β-2-himachalen-6-ol in colon cancer is mediated through its inhibition of the PI3K and MAPK pathways by Daaboul HE1, Daher CF2, Bodman-Smith K1, Taleb RI2, Shebaby WN2, Boulos J2, Dagher C3, Mroueh MA4, El-Sibai M5.(PubMed)
(4) Lifestyle Factors and Their Combined Impact on the Risk of Colorectal Polyps by Zhenming Fu, Martha J. Shrubsole, Walter E. Smalley, Huiyun Wu, Zhi Chen, Yu Shyr, Reid M. Ness, and Wei Zheng(PMC)
(5) Colorectal cancer: lifestyle and dietary factors by Corrêa Lima MP1, Gomes-da-Silva MH(PubMed)
(6) Key Statistics for Colorectal Cancer by American Cancer Society
(7) ERK and AKT phosphorylation status in lung cancer and emphysema using nanocapillary isoelectric focusing by Crosbie PA1, Crosbie EJ2, Aspinall-O'Dea M3, Walker M3, Harrison R4, Pernemalm M5, Shah R6, Joseph L7, Booton R8, Pierce A3, Whetton AD(PubMed)