Phytochemical Alliin Isolated From Garlic, Reduces the Levels of Triglyceride(TG) and Total Cholesterol(TC), According to Studies

By Kyle J. Norton
Fat including cholesterol and triglycerides consists of hydrocarbon molecules.

Cholesterol is the type of fat produced by the liver or from fat intake playing a critical role in the building of strong cell walls, production of vitamin D and steroid hormones, and bile acid to aid digestion in the small intestine.

Accessed cholesterol produced by the liver in a healthy individual is returned to the liver by high-density lipoprotein (HDL).

Overexpression of cholesterol levels in the bloodstream has been linked to plaques accumulation on the arterial walls, a major cause of some forms of heart disease and stroke.


The healthy ratio of HDL/LDL cholesterol is any numbers that are less than 1/4.

On the other hand, triglyceride is fat in the blood that comes from the outside source used by the body to convert to energy.

Triglyceride is stored in the fat cells used to produced energy between meals and in the case when food is scarce.

Compared to cholesterol, triglycerides in high levels also associated with the risk of heart disease, particularly in people with high levels of LDL and low levels of HDL.

Evolutionally, fat accumulation is considered a defense mechanism in the human body where excess fat is stored when food is plentiful and release to produce energy when food is scarce.

This defense mechanism has become deadly in Western countries where goods are always plentiful, leading to overweight and obesity in the induction of the onset of various types of chronic disease.

Dr. Karen Kearns, the lead scientist wrote, "Overweight and obesity prevalence was higher in men (43.0% and 16.1%) compared to women (29.2% and 13.4%), respectively. The most prevalent chronic conditions were lower back pain, hypertension, and raised cholesterol. Prevalence of chronic disease generally increased with increasing BMI".

And, "Compared to normal weight persons, the strongest associations were found in obese women for diabetes (RR 3.9, 95% CI 2.5-6.3), followed by hypertension (RR 2.9, 95% CI 2.3-3.6); and in obese men for hypertension (RR 2.1, 95% CI 1.6-2.7), followed by osteoarthritis (RR 2.0, 95% CI 1.2-3.2)".

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

On finding a potential compound for the prevention of triglycerides accumulation, researchers examined the effect of alliin on lipid accumulation in HepG2 cells.

According to tested data, injection of 1,3-dichloro-2-propanol (1,3-DCP), a food born hepatoxic chloropropanol contaminant significantly increased the intracellular content of triglyceride (TG) and total cholesterol (TC) at 0.5-2μg/mL.

Furthermore, 1,3-DCP also greatly decreased cyclic AMP (cAMP) level which plays an important role in the regulation of metabolism generally, particularly in fat accumulation in this case.

Moreover, 1,3-DCP also inhibited PKA and AMPK signaling pathways associated with the regulation of cellular energy homeostasis.

Additionally, 1,3-DCP significantly decreased GPR41 and GPR43 expression in brown adipogenesis associated with transfer energy from food into heat.

Collectively, 1,3-DCP enhanced the accumulation of fat in the tissue and inhibited the genes associated with the increase of metabolic efficiency.

Alliin, the most abundant sulfur compound in garlic, reversed all parameters changes caused by 1,3-DCP through its hypoglycemic, antioxidant, and anti-inflammatory activities.

In other words, alliin protects the body against abnormal lipid deposits caused by 1,3-DCP through its antioxidants, anti-hyperglycemic, and anti-inflammatory effects.

In HepG2 cells exposed to 1,3-DCP, alliin exhibited a significantly decreased increase of triglyceride(TG) and total cholesterol(TC).

Taken altogether, alliin may be considered supplements for the prevention and treatment of fat accumulation with no side effect, responding to the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Alliin attenuates 1, 3-dichloro-2-propanol-induced lipogenesis in HepG2 cells through activation of the AMP-activated protein kinase-dependent pathway by Lu J1, Cheng B1, Meng Z1, Fang B1, Li T2, Sun M1, Liu M1, Guan S. (PubMed)
(2) 1,3-dichloro-2-propanol induced lipid accumulation in HepG2 cells through cAMP/protein kinase A and AMP-activated protein kinase pathways via Gi/o-coupled receptors by Lu J1, Fang B2, Zheng Y2, Yu X2, Huang G2, Wang Z2, Deng X3, Guan S. (PubMed)
(3) Chronic disease burden associated with overweight and obesity in Ireland: the effects of a small BMI reduction at population level by Karen Kearns,1,5 Anne Dee,2 Anthony P Fitzgerald,1,4 Edel Doherty,3 and Ivan J Perry. (PMC)

Beta-Sitosterol Protects the Kidneys Against Nephrotoxicity

By Kyle J. Norton

The kidneys are essential bean shape organ of our body, located just below the rib cage, one on each side of your spine.

Kidneys play a critical role in filtering blood with billions of glomeruli by separating the cells of blood from plasma and reabsorb back substances, and secret waste such as urea and ammonium that are stored into pelvis then into the ureter to the bladder.

Furthermore, kidneys also process the functions that regulate electrolytes, blood pressure, maintains acid-base balance, produce hormone calcitriol, renin, and erythropoietin, etc.

In the urinary system, the kidney also reabsorbed back substances into the blood, while other wastes, such as urea and ammonium are stored into pelvis then into the ureter to the bladder.

Nephrotoxicity or acute kidney failure is a condition of toxicity in the kidneys.

The disease is caused by a poisonous effect of prolonged use of certain medications and the accumulation of harmful chemicals.

According to the American physician association, long term use of penicillins, cephalosporins, sulfonamides, thiazide diuretics, furosemide, NSAIDs and rifampicin are associated to increase damage to the kidney.

And people with age over 60 are at increased risk of nephrotoxicity if the above medicines are prescribed for prolonged periods.

The most common symptoms of nephrotoxicity decreased urine output, fluid retention, causing swelling in your legs, ankles or feet, weakness, fatigue, and irregular heartbeat.

In severe cases, patients may also experience symptoms of shortness of breath, and confusion.
acute nephrotoxicity.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the prevention and treatment of kidney diseases, researchers evaluated the nephroprotective effect of β-sitosterol against nephrotoxicants, using renal function markers, antioxidant and lipid peroxidation status, and inflammatory markers.

The study included male albino Wistar rats that were randomly grouped into four:
* Group 1 was vehicle control rats (0.1% carboxymethyl cellulose [CMC]); 

* Group 2 was rats treated with N-diethylnitrosamine (DEN) (200 mg/kg body weight [bw] i.p. on the 15th day) and ferric nitrilotriacetate (Fe-NTA) (9 mg/kg BW i.p. on 30th and 32nd days);

* Group 3 was rats that received β-sitosterol (20 mg/kg BW in 0.1% CMC, p.o. for 32 days) 2 weeks prior to the exposure to the nephrotoxic; and

* Group 4 was rats that received β-sitosterol alone

According to the chemical analysis, after the experiments were terminated after the 24 h of the last dosage of Fe-NTA, and all the animals were sacrificed, 

* All the parameters showed significant changes in DEN and Fe-NTA treated animals.

* β-sitosterol pretreated animals' altered biochemical parameters were restored to near normal.

More precisely, β-sitosterol activated the expression of antioxidant enzymes enhancer Nrf2 gene expression against renal oxidative stress markers.

The administration of β-sitosterol exerted a strong protective effect in biochemical parameters against nephrotoxicity induced rats, according to the histopathological and immunohistochemical observations,

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of obese neral toxicity, pending to the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources

(1) Nephroprotective effect of β-sitosterol on N-diethylnitrosamine initiated and ferric nitrilotriacetate promoted acute nephrotoxicity in Wistar rats by Sharmila R, Sindhu G, Arockianathan PM. (PubMed)

Tocopherols Inhibits the Adverse Effects Osteoradionecrosis (ORN)-Induced by Radiotherapy in Patients with Head and Neck

By Kyle J. Norton


Head and neck cancer is a group of cancers found in the mouth, throat, larynx, sinuses, or salivary glands.

Most cases of head and neck cancer, at the early stage, start by the cell growth irregularly and disorderly on the surface of the inner lining in the head and neck.

At the advanced stage, patients may experience symptoms of a lump in the nose, neck or throat, with or without pain, a persistent sore throat that does not heal, trouble swallowing (dysphagia) and frequent and persistent coughing.

At this stage, cancer cells may travel a distance away from the original site to infect other healthy tissue and organs.

Most common head and neck cancer metastases are secondary skin cancer.

The exact causes of head and neck cancer are unknown. However, certain risk factors have been found to associate with the onset of the disease, including, excessive alcohol intake, smoking, infected by the HPV virus, poor oral health, race, long-term exposure to wood dust.

Some researchers suggested that people who perform oral sex before sexual intercourse is at a higher incidence of disease development as human papillomavirus (HPV) can spread during oral sex, increasing the possibility of oral cancer.

According to the statistics, in the US, HPV is the most common sexually transmitted virus.

Osteoradionecrosis is a condition associated with bone death due to exposure to radiation or radiation treatment.

The death of bone cells is a result of radiation induce-damage of the blood vessel that supplies the nutrients to the bone.

Osteoradionecrosis is a rare side effect occurred sometime after radiation therapy has ended. The complication usually occurs in the lower jaw or mandible.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of chronic diseases, researchers examined the prophylactic role of pentoxifylline and tocopherol in patients who require dental extractions after radiotherapy with cancer of head and neck adverse effects osteoradionecrosis (ORN).

The retrospective study included a total of 110 patients who had radiotherapy for cancer of the head and neck.

According to the analysis of 450 dental extractions 110 patients after radiotherapy, ORN developed only in 2 patients.

However, patients had taken PVe for a mean of 12 (24) weeks preoperatively and 14 (18) weeks postoperatively showed a lower ORN incidence than normally associated with dental extractions in irradiated patients.

Based on the results, researchers said, "In patients undergoing dental extractions, after receiving radiotherapy of head and neck region, combination therapy of pentoxifylline and tocopherol are sufficiently effective".

Taken altogether, tocopherols may be considered a supplement for reducing side effects of cancer of head and neck adverse effects osteoradionecrosis (ORN), pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Prophylactic Use of Pentoxifylline and Tocopherol in Patients Undergoing Dental Extractions Following Radiotherapy for Head and Neck Cancer by Aggarwal K1, Goutam M2, Singh M2, Kharat N3, Singh V4, Vyas S5, Singh HP. (PubMed)

Topical Turmeric Extract Processes Anti Aging Activity in Vitro

By Kyle J. Norton

Aging is a natural and biological process that cannot be prevented.

Skin aging is one of the most visible processes which occurs constantly in our skin organ.

However, actively engaging healthy living lifestyle by increasing the intake of good healthy food such as whole grain, fruits, vegetables, beans, and legumes, etc. and reducing the consumption of harmful foods, such as saturated fat, trans fat, artificial ingredients, etc. accompanied with moderate exercise has been found to delay aging progression.

In other words, it is possible that a person has physiological younger than his or her biological age.


There many theory that explains the aging processes. According to the free radical theory, oxidative damage to the enzymes, other proteins, unsaturated fatty acids, phospholipids, DNA and RNA, etc., caused by free radical chain reaction can lead to aging of the organisms by attacking the lipid bilayers of the cell walls.

You can view other theories of aging by click this link.

There are many risk factors associated with aging and premature aging processes. Dr. Bhatt N in the assessment of the risk factors and self-perception for facial aging among the Nepalese population wrote, "Around 50% of attendees were conscious about facial health, 53% perceived their facial age as their chronological age, 39% used some facial care products, and 68% were aware of the risk factors for facial aging".

And "The major perceived risk factors were unhealthy eating habits, stress, less exercise, dehydration, diseased state, and sleeping habits. A significant association was found between increasing age, place of birth in hills or mountains and sun exposure with high wrinkling score".

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a better compound for the treatment of skin aging, researchers determined the antiaging activity of Curcuma heyneana to prove its traditional use as skincare, for cosmetic and body freshness.

In vitro, according to the tested assay, the extracts showed a dose-dependent manner in the final concentration range from 62.5 to 500 µg/mL in the inhibition of free radical expression and 31.25 to 250 µg/mL for tyrosinase and collagenase.

The extract containing a high amount of curcuminoid (CUR), the active principle of Curcuma is the best antioxidant, that acts as a tyrosinase inhibitor, and collagenase inhibitor, compared to those with a low concentration of CUR.

The topical application of the crude extract also induced significant improvement effects on the UV-induced skin structure damage.


By examining the efficacy of constituent of the extracts, researchers found that total CUR content was correlated with the anti-aging activity.


Based on the findings, researchers said, "The results show that C. heyneana contains antioxidant compounds and has potent anti-aging activity, indicating that it can be used as an anti-aging drug candidate or as a phyto-cosmeceutical".

Taken altogether, turmeric in form of extract may be considered supplements used for the treatment of skin aging, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-aging properties of Curcuma heyneana Valeton & Zipj: A scientific approach to its use in Javanese tradition by Kusumawati I1, Kurniawan KO2, Rullyansyah S2, Prijo TA3, Widyowati R2, Ekowati J4, Hestianah EP5, Maat S6, Matsunami K7. (PubMed)
(2) Development and evaluation of topical films containing phytoestrogenic diaryheptanoids from Curcuma comosa extract by Tuntiyasawasdikul S1, Limpongsa E1, Jaipakdee N1, Sripanidkulchai B. (PubMed)
(3) Risk factors and self-perception for facial aging among Nepalese population by Bhatt N1, Agrawal S1, Mehta K. (PubMed)

Proanthocyanidin (cPAC) Found in Cranberry May be Used as Repressing Antibiotic Against Resistance Gram-Negative Bacteria, Researchers Find

By Kyle J. Norton

Antibiotics are a group of conventional medicines used for the treatment of bacterial, fungal parasitic,... infection.

The medications have no effects on viral infection.

Infection is a disease caused by microorganism invasion.

After entering the body, the organisms selectively find a specific tissue or organ to start their multiplication.

Most infectious diseases can be passed from infected person to person or transmitted by bites from insects or animals.

However, the acquired infectious diseases can also be caused by ingesting contaminated food or water or being exposed to organisms in the environment.

Most organisms before having a chance to induce infection are killed off by the immune system response in the acute phase of infection, by stimulating the production of a proinflammatory cytokine.

Unfortunately, if the immune system fails to destroy the invasive organism within a set period of time, normally in a few weeks, it will adapt to the change, causing chronic infection.


Antibiotics have been found to cause digestive discomforts such as nausea, indigestion. vomiting, diarrhea, bloating. the feeling of fullness, and loss of appetite, and stomach cramping or pain, acutely.


Chronic use of antibiotics also induces more serious adverse effects, including skin rash, skin allergic reactions, upset stomach, and fungal (yeast) vaginal infections or oral thrush by weakening the immune system.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of infectious diseases, researchers investigated the antibacterial activity of cranberry proanthocyanidin (cPAC) on resistance to tetracycline in Escherichia coli and Pseudomonas aeruginosa.


According to the tested assays, cPAC exerted a potentiating effect, both in vitro and in vivo, on a broad range of antibiotic classes against pathogenic E. coli, Proteus mirabilis, and P. aeruginosa.

cPAC demonstrated the antibacterial effect through two antibiotic resistance mechanisms, namely, selective membrane permeability, and multidrug efflux pumps.


Based on the evidence, researchers said, " The use of cPAC to potentiate antibiotics and mitigate the development of resistance could improve treatment outcomes and help combat the growing threat of antibiotic resistance".

Taken altogether, cranberry may be considered an adjunct therapy as an antibiotic against bacterial pathogens, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Proanthocyanidin Interferes with Intrinsic Antibiotic Resistance Mechanisms of Gram-Negative Bacteria by Maisuria VB1, Okshevsky M1, Déziel E2, Tufenkji N. (PubMed)

Moronic Acid Found in Rhus javanica, Mistletoe,..., A Promising Antidiabetic Antioxidant and Phytochemical

By Kyle J. Norton

Diabetes is a chronic low-grade inflammatory condition caused by insufficient insulin entering the bloodstream to regulate glucose.

In other words, diabetes occurs when cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

Inflammation is a natural defense of the immune system that protects the body against the insult from foreign invasion.

Acute inflammation occurs quickly or within the hours and lasts a few days or weeks and the damaged tissues are healed themselves after all pathogens are killed off.

However, if the immune system can not completely eradicate all invaders in the acute phase of infection, it will compromise, leading to chronic low-grade inflammation, a major cause of cardiovascular disease, arthritis, and diabetes.

Chronic inflammation is a low-grade inflammation caused by the inability of the immune system to eliminate the invasive pathogens that occurred in the acute phase of infection.

Any inflammation that lasts more than 8 weeks is considered chronic inflammation.

Believe it or not, worldwide, 3 of 5 death are results from chronic inflammatory diseases like stroke, chronic respiratory diseases, heart disorders, cancer, obesity, and diabetes.

In the US, chronic inflammatory diseases affect more than 50 million Americans each year.

Sub-chronic diabetic treatment is a process associated with the treatment of diabetes that lasts only in a moderate or intermediate duration.


Moronic acid is a phytochemical in the subclass of Triterpenoid, belonging to the group of Terpenes found extracted from Rhus javanica, Mistletoe, etc.

On finding a potential phytochemical for the treatment of diabetes, researchers examined the ix derivatives (1-6) of moronic acid that were semi-synthesized and their in vitro protein tyrosine phosphatase 1B (PTP-1B) inhibition activity in diabetes.* In rat induced diabetes, derivatives 2 (IC50=10.8 ± 0.5 μM) and 6 (IC50=7.5 ± 0.1 μM) displayed the most potent inhibitory activity.

* The derivatives decreased plasma glucose levels during all the experiments in vitro and vivo.

* Most importantly, The #2 had polar and Van der Waals interactions in both sites with Val49, Gln262, Met258, Phe182, Ala217, Ile219, and Gly259 and # 6 showed polar interaction with Gln262 and Van der Waals with Val49, Ile219, Gly259, Arg254, Ala27, Phe52, Met258, the proteins associated with the onset of diabetes.
Based on the findings, researchers said, "derivatives 2 and 6 have the potential for the development of antidiabetic agents".

Taken altogether, moronic acid may be considered a remedy for the treatment of diabetes in a short duration, pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) In vitro and in silico PTP-1B inhibition and in vivo antidiabetic activity of semisynthetic moronic acid derivatives by Cerón-Romero L1, Paoli P2, Camici G2, Flores-Morales V3, Rios MY4, Ramírez-Espinosa JJ1, Hidalgo-Figueroa S1, Navarrete-Vázquez G1, Estrada-Soto S. (PubMed)

Tocopherols Intake with Selenium May Increase the Risk of Prostate Cancer

By Kyle J. Norton

Prostate warped around the around a tube (the urethra) is a gland of the male reproductive system found in front of the rectum and just below the bladder.

The prostate gland also makes and stores semen

Prostate enlargement is the condition that the prostate gland has grown bigger. The condition has been found in almost all aging males.

More precisely, by the age of 40, the levels of testosterone of men start to decrease resulting in the increase of the by-product prolactin of testosterone that stimulates the production of the enzyme 5-alpha reductase induce-the conversion of testosterone to dihydro-testosterones DHT triggering prostate enlargement and prostate cancer. 

Primary prostate cancer normally starts from the cell on the surface of the inner lining of the prostate tissue and gradually spreads to the deeper part of the prostate.

Most prostate cancers are slow-growing and prostate cancer may be detected during physical (rectum) exams.

At the early stage, patients may not experience any symptoms, However, at the advanced stage, prostate cancer can induce symptoms of blood in the urine, frequent urination and urinary difficulty.

The cancer cells at this stage can also travel a distance away from the prostate to invade other healthy tissue and organ, leading secondary metastasis tumors.

According to the statistic, the 5-year survival rate for local and regional (stage 0 and 1) stages of prostate cancer is nearly 100%.

More than 80% of prostate cancers are diagnosed in men who are 65 or older. Therefore, men who are at higher risk of prostate cancer due to family history and increase in age and inherited gene changes should have their prostate gland checked annually.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of chronic diseases, researchers examined the effect of supplementation plasma α-tocopherol or γ-tocopherol in overall or high-grade prostate cancer.

The stratified case-cohort sample that included 1,746 incident prostate cancer cases diagnosed through June 2009 and a subcohort of 3,211 men derived from the SELECT trial of 35,533 men.

According to plasma were collected at entry from 2001 to 2004, and median follow-up was 5.5 years (range, 0-7.9 years),
* Men with higher α-tocopherol concentrations seemed to have risk similar to that of men with lower concentrations [overall HR for fifth (Q5) vs. first quintile (Q1), 1.21; 95 % confidence interval (CI), 0.88-1.66; P-trend = 0.24; in the trial placebo arm, Q5 HR, 0.85; 95% CI, 0.44-1.62; P-trend = 0.66].

In other words, plasma α-tocopherol does not influence the risk of prostate cancer.

* A strong positive plasma α-tocopherol association among men receiving the trial selenomethionine supplement [Q5 HR, 2.04; 95% CI, 1.29-3.22; P-trend = 0.005].

* A positive plasma α-tocopherol-prostate cancer association also seemed limited to high-grade disease (Gleason grade, 7-10; overall Q5 HR, 1.59; 95% CI, 1.13-2.24; P-trend = 0.001; among men receiving selenomethionine, Q5 HR, 2.12; 95% CI, 1.32-3.40; P-trend = 0.0002).

Where selenomethionine is an amino acid containing selenium

Based on the results, researchers said, "higher plasma α-tocopherol concentrations may interact with selenomethionine supplements to increase high-grade prostate cancer risk, suggesting a biologic interaction between α-tocopherol and selenium itself or selenomethionine".

Taken altogether, intake tocopherols together with selenomethionine may increase the risk of prostate cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Plasma tocopherols and risk of prostate cancer in the Selenium and Vitamin E Cancer Prevention Trial (SELECT) by Albanes D1, Till C2, Klein EA3, Goodman. (PubMed)
(2) Plasma carotenoids, retinol, and tocopherols and the risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition study by Key TJ1, Appleby PN, Allen NE, Travis RC, Roddam AW, Jenab M, Egevad L, Tjønneland A, Johnsen NF, Overvad K, Linseisen J, Rohrmann S, Boeing H, Pischon T, Psaltopoulou T, Trichopoulou A, Trichopoulos D, Palli D, Vineis P, Tumino R, Berrino F, Kiemeney L, Bueno-de-Mesquita HB, Quirós JR, González CA, Martinez C, Larrañaga N, Chirlaque MD, Ardanaz E, Stattin P, Hallmans G, Khaw KT, Bingham S, Slimani N, Ferrari P, Rinaldi S, Riboli E. (PubMed)