Omega-3 Fatty Acids Process a Strong Impact on the Parameters Associated with Endocrine Disorder

By Kyle J. Norton

Ovarian cysts affect women of all ages, especially during a woman's childbearing years. Most ovarian cysts are functional and benign but some can become cancerous.

Some ovarian cysts can cause bleeding and pain such as endometriomas/chocolate cysts and surgery is required for any cyst larger than 5 cms in diameter or if the cyst has interfered with the extruding of mature follicle.

Traditional Chinese medicine defines ovarian cyst as a medical condition caused by excess- dampness (caused by blood and fluid stasis) accumulated in the abdomen and gradually coalesces into phlegm, which can manifest ovarian cysts and chocolate cysts.

In conventional medicine, an ovarian cyst is a collection of fluid, surrounded by a very thin wall, within an ovary.

Polycystic Ovarian Syndrome is endocrinologic diseases caused by undeveloped follicles clumping on the ovaries that interfere with the function of the normal ovaries as resulting of enlarged ovaries, leading to hormone imbalance( excessive androgen),

Epidemiologically, PCOs have been found to induce in male pattern hair development, acne, irregular period or absence of period, weight gain and infertility. 

More precisely, PCOs cause reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovascular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). 

Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase the risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

The condition affects over 5% of women population or 1 in 20 women.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of the endocrine disorder, researchers assessed the effectiveness and safety of omega-3 fatty acid for patients with polycystic ovary syndrome (PCOS).

The meta-analysis, data from randomized controlled trials included 9 trials involving 591 patients obtained to compare the effects of omega-3 fatty acid versus placebo or western medicine in women with PCOS.

According to the results of the analysis, compared to the control group, 

* Omega-3 fatty acid improved HOMA index associated with β-cell function and insulin resistance (IR) from basal (fasting) glucose and insulin or C-peptide concentrations.

* Furthermore, Omega-3 fatty acid was found to decrease TC and TG level [TC: (WMD -9.43; 95% CI -11.90, - 6.95; P<0. 00001); TG: (WMD -29.21; 95% CI -48.08, - 10.34; P = 0. 002)], which were levevated in patients with PCOS.

* Additionally, omega-3 fatty acid increases adiponectin level secreted by adipose tissue which was lows in PCOs compared to normal subjects.

Based on the findings, researchers said, "omega-3 fatty acid may be recommended for the treatment of PCOS with insulin resistance as well as high TC (especially LDL-C) and TG".

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the treatment of PCOS, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of omega-3 polyunsaturated fatty acids on steroidogenesis and cellular development in PCOS rats by Hu X 1, Weng X, Tian Y, Wang C, Yang Y, Xu K, Zhang C. (PubMed)
(2) Effectiveness of Omega-3 fatty acid for polycystic ovary syndrome: a systematic review and meta-analysis by Yang K1, Zeng L1, Bao T2, Ge J. (PubMed)
(3)The Holistic prevention, management, and treatment of Polycystic Ovarian Syndrome: The Risk Factors(Revised edition with Citations) by Kyle J. Norton