Thursday, 7 February 2019

Ginger, the Remedy Effect On Fat and Glucose Metabolism Under Stress

By Kyle J. Norton

Scientists may have found a pungent spice which improves the fat and glucose metabolism under  stress, according to studies.

Psychological stress is the expression of emotion and physiology when the events happened to an individual going beyond his/her coping ability.

However, the coping resources for coping with the stress of each individual are quite different. Some can cope better than others when dealing with the same unfortunate events.

Psychologic stress was found to induce physiologic responses, leading to physical symptoms and disease. In some cases, the impacts of psychologic stress can result in the worsening of individuals' medical conditions.

According to the epidemiological studies, chronic psychological stress can cause symptoms anxiety and nervousness, panic attacks, physical sensations of anxiety, tendencies to predict the worst, conflict avoidance, muscle tension, tremors, headaches, low/excessive motivation. 

If you have experienced some of the above symptoms, you may have chronic psychological stress, please make sure you check with your doctor to rule out the possibility.

Some researchers suggested that psychological stress can increase or decrease the production of certain hormones, causing a significant change in one life physically and psychologically, if the change has become chronic.

Dr. Salam Ranabir, the lead scientist in examing the stress impacts on hormones, said, "In the modern environment one is exposed to various stressful conditions. Stress can lead to changes in the serum level of many hormones including glucocorticoids, catecholamines, growth hormone, and prolactin"

And, " Some of these changes are necessary for the fight or flight response to protect oneself. Some of these stress responses can lead to endocrine disorders like Graves’ disease, gonadal dysfunction, psychosexual dwarfism, and obesity. Stress can also alter the clinical status of many preexisting endocrine disorders such as precipitation of adrenal crisis and thyroid storm".

These results suggested clearly that people under long-term stress are susceptible to the onset of abnormal hormone-related diseases and syndrome.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding natural ingredients for the improvement of fat and glucose metabolism examined the effects of individual spice including ginger physiological responses to high-fat meals.

These results strongly suggested that a meal containing a high antioxidant spice blend attenuated postprandial lipemia by 30% compared to a low spice meal through the influence of acute psychological stress on fat metabolism.

The a 2 x 2, randomized, 4-period crossover design  in 20 healthy but overweight adults, researchers compared the effects of 14.5 g spices (black pepper, cinnamon, cloves, garlic, ginger, oregano, paprika, rosemary, and turmeric) vs. placebo incorporated into a high fat meal (1000 kcal, 45 g fat), followed by psychological stress (Trier Social Stress Test) vs. rest on postprandial metabolism.

According to the blood sample collected at baseline and at 105, 140, 180, and 210 minutes for analysis of triglycerides, glucose, and insulin, the levels of serum triglycerides, glucose and insulin were elevated following the meal.

Application of spices, including ginger reduced post-meal triglycerides by 31% followed by the rest condition (p = 0.048), however, this effect was not presented during stress.

Furthermore, the significant increase of acute stress of the tested subjects also had a strong impact to negate the activity of spice on levels of glucose or insulin.

Moreover, The spice blend and several of the individual spices dose-dependently inhibited PL and PLA2activity in vitro.

Where Phospholipase (PL) and Phospholipase A2 (PLA) are associated with the development of stress and inflammation.

Dr. the lead scientist after taking into account co and confounders said, "spices may attenuate postprandial lipemia via inhibition of PL and PLA2. However, the impact of psychological stress negates any influence of the spice blend on triglycerides, and further, increases blood glucose and insulin".

The finding strongly suggested ginger showed no effects in inhibiting triglycerides and modulating the levels of glucose and insulin in people who are under constant psychological stress.

Interestingly, in order to reveal more information about ginger against psychological stress, researchers evaluated the activity 6-gingerol on C. elegans.

The bioactive compound 6-gingerol was isolated from the most active ethyl acetate soluble fraction of ginger and showed an elevated survival rate of worms against stressful environment including thermal, osmotic, and oxidative conditions.

The results were attributed to the 6-gingerol activity in the elevated the antioxidant enzyme activities of C. elegans, in the reduction of intracellular reactive oxygen species (ROS) accumulation in worms in a dose-dependent manner.

More importantly, the injection of 6-gingerol demonstrated that the increased stress tolerance of 6-gingerol-mediated worms could result from the promotion of stress resistance proteins such as heat shock protein (HSP-16.2) and superoxide dismutase (SOD-3). 

Taken all together, ginger exerted significant antioxidative stress through its bioactive compound compared to no effects in modulating the triglycerides, blood glucose, and insulin if a person is under acute psychological stress.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Longevity and Stress Resistant Property of 6-Gingerol from Zingiber officinale Roscoe in Caenorhabditis elegans by Eun Byeol Lee,1 Jun Hyeong Kim,1 Chang Wan An,1 Yeong Jee Kim,1 Yun Jeong Noh,1Su Jin Kim,1 Ju-Eun Kim,1 Abinash Chandra Shrestha,1 Ha-Neul Ham,1 Jae-Yoon Leem,1Hyung-Kwon Jo,2 Dae-Sung Kim,2 Kwang Hyun Moon,3 Jeong Ho Lee,3 Kyung Ok Jeong,3 andDae Keun Kim. (PubMed)
(2) Effects of culinary spices and psychological stress on postprandial lipemia and lipase activity: results of a randomized crossover study and in vitro experiments by Cindy E McCrea, Sheila G West, Penny M Kris-Etherton, Joshua D Lambert, Trent L Gaugler,Danette L Teeter, Katherine A Sauder, Yeyi Gu, Shannon L Glisan, and Ann C Skulas-Ray. (PMC)
(3) Stress and hormones by Salam Ranabir and K. Reetu. (PMC)

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