Healthy food papaya and cholesterol

Papaya is a species of Carica Papaya, belongs to the family Caricaceae and native to the tropics of the Americas, and was first cultivated in Mexico and several centuries

Nutrients
1. Carbohydrates
2. Sugars
3. Fiber
4. Protein
5. Vitamin A
6. Thiamine (Vitamin B1)
7. Riboflavin (Vitamin B2)
8. Niacin (Vitamin B3)
9. Vitamin B6
10. Vitamin C
11. Vitamin E
12. Vitamin K
13. Calcium
14. Iron
15. Magnesium
16. Phosphorus
17. Potassium
18. Sodium
19. Etc.

Chemical constituents
Alkaloids, Cardenolides, Anthraquinones, Saponins, Tannin, phenol, flavonoid, anthocyanin, Benzyl glucosinolate, benzylisothiocyanate, 5-(Hydroxymethyl)-2-furancarboxaldehyde, 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one and 1,3-dihydroxy-2-propanone, etc.(a)

Carica papaya and cholesterol
Cholesterol is needed for our body to build cell walls, make hormones and vitamin D, and create bile salts that help you digest fat. However too much of it can be dangerous because cholesterol cannot dissolve in your blood
Ficus carica leaf extract modulates, on hyperlipidemia in high fat diet (HFD)-induced obese male rats, showed to improve the lipid profile and decreased adipogenic risk factors, most likely mediated through an increase in HDL-C levels(1) and streptozotocin-induced diabetic rats, it also exerted hypoglycemic and antioxidant effect;, through improved the lipid profile and affected integrity and function of both liver and pancreas(2). Ether- and water-soluble fractions of Carica papaya ethanol extract, on the other hand, in dose-dependent manner inhibited the total cholesterol (TC), triglycerides (TG), low-density lipoproteins (LDL) level, and significantly increased high-density lipoprotein (HDL) level(3). Unfortunately, according to the Institute for Medical Research, C. papaya leaf extract at a dose over fourteen times the levels employed in practical use in traditional medicine may induce toxicity(4).

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References
(a) Chemical composition and bioactivity of dried fruits and honey of Ficus carica cultivars Dottato, San Francesco and Citrullara by Loizzo MR¹, Bonesi M, Pugliese A, Menichini F, Tundis R.(PubMed)
(1) Ficus carica leaf extract modulates the lipid profile of rats fed with a high-fat diet through an increase of HDL-C by Joerin L¹, Kauschka M, Bonnländer B, Pischel I, Benedek B, Butterweck V.(PubMed)
(2) Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats by Juárez-Rojop IE¹, Díaz-Zagoya JC, Ble-Castillo JL, Miranda-Osorio PH, Castell-Rodríguez AE, Tovilla-Zárate CA, Rodríguez-Hernández A, Aguilar-Mariscal H, Ramón-Frías T, Bermúdez-Ocaña DY.(PubMed)
(3) Effect of ether- and water-soluble fractions of Carica papaya ethanol extract in experimentally induced hyperlipidemia in rats by Iyer D¹, Sharma BK, Patil UK.(PubMed)
(4) Repeated dose 28-days oral toxicity study of Carica papaya L. leaf extract in Sprague Dawley rats by Afzan A¹, Abdullah NR, Halim SZ, Rashid BA, Semail RH, Abdullah N, Jantan I, Muhammad H, Ismail Z.(PubMed)