#CascaraSagrada Aloe-Emodin Inhibits Proteins Associated with the Apoptosis of Primary #Glioblastoma Cells, Scientists Suggest

Kyle J. Norton

Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America, its bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc. 

Bone cancer is an abnormal growth of cells within the bone that have become cancerous. Bone cancer may be classified as primary cancer originating in the bone, and secondary cancer originating from elsewhere.

The health benefits of Aloe-emodin have been found to be effective in induced cell anti-proliferation and apoptosis in some cancer cell lines. In U87 human malignant glioma cells, the chemical constituent found in Cascara Sagrada,

Aloe-emodin also arrested the cell cycle in the synthesis phase of the cell cycle and promoted the loss of mitochondrial membrane potential in U87 cells, leading to early events of the mitochondria-induced apoptotic pathway. 

Other studies of dimethylsulfoxide (DMSO; control) or aloe-emodin (40 microM) showed the effect of Aloe-emodin in inducing apoptosis in U-373MG glioma cells by suppressed PKC(a family of protein) activity and reduced the protein content of most of the PKC isozymes. These results support the positive effect of aloe-emodin and may be considered as a potential agent in treating human malignant glioma cells.


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References
(1) Enhanced induction of cell cycle arrest and apoptosis via the mitochondrial membrane potential disruption in human U87 malignant glioma cells by aloe-emodin by Ismail S, Haris K, Abdul Ghani AR, Abdullah JM, Johan MF, Mohamed Yusoff AA.(PubMed)
(2) Aloe-emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells by Acevedo-Duncan M, Russell C, Patel S, Patel R.(PubMed)