Cardiomyocyte hypertrophy is a medical condition characterized by the thickening of the heart muscle, leading to reduced function of the heart in pumping blood throughout the body.
The heart-formed part of the circulatory system is a muscular organ that pumps blood through the body's blood vessels to provide oxygen and nutrients and remove metabolic wastes.
The heart muscles made up the bulk of the heart’s mass control the heartbeat with high contractile strength and endurance.
Cardiac muscle also has a unique function to regulate heart performance by spreading electrochemical signals to all cells in the heart.
Damage of the heart muscle has been found to induce blood vessel diseases, such as coronary artery disease; heart rhythm problems (arrhythmias).
In some cases, heart muscle disease also is found in patients with congenital heart defects.
The most common symptoms of cardiac hypertrophy are breathlessness with exertion or at rest, legs, ankles, and feet swelling. persistent fatigue, dizziness, lightheadedness, and fainting, particularly, in the symptoms of irregular heartbeats.
Conventionally, treatments of cardiac hypertrophy are totally depending on the type of heart disease, including lowering blood pressure medication such as ACE inhibitors; lowing the heart rate, such as beta-blockers, normalizing heart beating, and balancing electrolytes in the body.
Making a healthy lifestyle change and moderate exercise may also recommend by your doctor.
Cardiac hypertrophy has been found in patients with uncontrol high blood pressure accompanied by tobacco smoking. The condition is a common risk factor for heart attack and stroke.
Dr. Thomas Kahan, the lead scientist wrote, "Myocardial hypertrophy is also part of the remodeling process following an acute myocardial infarction, and is a common finding in patients with congestive heart failure caused by systolic and/or diastolic LV dysfunction".
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On findings a potential compound for the treatment of heart failure, researchers examined the efficacy of curcumin an anti-hypertrophic potential.
According to the tested analysis, curcumin encapsulated by carboxymethyl chitosan (CMC) nanoparticle conjugated to a myocyte specific homing peptide was effective in the regression of cardiac hypertrophy in a rat (Rattus norvegicus) model.
Curcumin at a low dose of 5 mg/kg body weight compared to free Curcumin at 35 mg/kg body weight. showed a higher cardiac bioavailability, compared to other concentrations.
Furthermore, cardiac function during hypertrophy was significantly improved by the application of Curcumin/CMC-peptide by inhibiting the hypertrophy marker genes (ANF, β-MHC) and apoptotic mediators (Bax, Cytochrome-c) and activity of apoptotic markers (Caspase 3 and PARP) in the lower doses compared to higher doses.
Targeted Curcumin treatment significantly lowered p53 expression which is associated with pro-apoptotic function in cardiac hypertrophy.
Based on the findings, researchers wrote, "Curcumin and also attributes towards probable mechanistic insight into its therapeutic potential as a cardio-protective agent for regression of cardiac hypertrophy".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of cardiac hypertrophy, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
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Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Improved bioavailability of targeted Curcumin delivery efficiently regressed cardiac hypertrophy by modulating apoptotic load within cardiacmicro environment by Ray A1, Rana S2, Banerjee D3, Mitra A4, Datta R5, Naskar S6, Sarkar S. (PubMed)
(2) Left ventricular hypertrophy in hypertension: its arrhythmogenic potential by Thomas Kahan1 and Lennart Bergfeldt. (PMC)
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