Sunday 30 August 2020

Lower Dose of Cabbage Kills Breast Cancer Cells in Vitro

By Kyle J. Norton

Cancer is a class of diseases in which a group of cells growing and multiplying disorderly and uncontrollably in our body.

The women's breasts are made up of specialized tissue that produces milk (glandular tissue) and fatty tissue. The size of a women's breast is totally determined by the amount of fat.

Breast cancer is a medical condition characterized by cell growth irregularly and disorderly in the breast tissue.

Most cases of breast cancer start in the cell on the surface of the inner lining of the breast tissue before spreading into deeper layers of the breast.

Breast cancer is first noticed as a painless lump in the breast or armpit and most often discovered by the women themselves.

In some cases, breast cancer can also be noticed by the woman partner or during the doctor's routine physical exam.

However, breast skin irritation or dimpling, nipple pain, nipple retraction (turning inward), redness and scaliness that cannot be healed within 3 weeks are also the signs and symptoms of breast cancer.

In Canada, according to the statistic, 11% of women will develop breast cancer by the time they reach 90 years of age.

Just about 20% of breast cancers in Canada are diagnosed in women under 50, while almost 30% are diagnosed in women over 70 years of age.

Breast cancer diagnosed in the early stage have a 5-year survival rate of 100%. Therefore, women at a higher risk of breast cancer should examine their breasts at least once a month for preventive measures.


Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem of which is crowded a mass of leaves, usually green but in some varieties, it may be red or purplish.

With an aim to find a natural food for the prevention of cancers, researchers compared the cruciferous vegetable extracts from freeze-dried cabbage (FDC), freeze-dried fermented cabbage (FDS), and acidified Brussels sprouts (ABS) on human breast cancer cell lines.

According to the tested differentiation, the experimental extracts bounded with low affinity to the ER, and the relative binding affinity is estradiol > FDS > FDC > ABS and reduced 1 nM estradiol-induced MCF-7 cell proliferation at low concentrations (5-25 ng/mL).

Interestingly, extracts at 25 ng/mL inhibited breast cancer markers estradiol-induced pS2 mRNA expression, but at higher extract concentrations (50 ng/mL-25 microg/mL), the extracts increased proliferation in MCF-7 cells and pS2 gene at the higher extract concentrations (0.25-25 microg/mL).

In other words, at low concentrations which are in the range from 5-25 ng/mL, freeze-dried cabbage (FDC), freeze-dried fermented cabbage (FDS) inhibited the MCF breast cancer cell proliferation.

Based on the results, researchers wrote, "This study demonstrates that cruciferous vegetable extracts act bifunctionally, like an antiestrogen at low concentrations and an estrogen agonist at high concentrations.".

Taken altogether, cabbage may be considered a remedy for the prevention and treatment of breast cancer at low doses, pending to the confirmation of the larger sample size and multicenter human study.



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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Estrogenic effects of extracts from cabbage, fermented cabbage, and acidified brussels sprouts on growth and gene expression of estrogen-dependent human breast cancer (MCF-7) cells by Ju YH1, Carlson KE, Sun J, Pathak D, Katzenellenbogen BS, Katzenellenbogen JA, Helferich WG. (PubMed)

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