Tocopherols in the prevention of Chronic Epilepsy

By Kyle J. Norton

Epilepsy is a condition of a neurological disorder caused by abnormal electrical activity in the brain inducing sudden recurrent episodes of sensory disturbance and convulsions.

A seizure is a sudden, uncontrolled electrical disturbance in the brain induced the changes to patients' behavior, movements or feelings, and levels of consciousness.

Patients with have two or more seizures or a tendency to have recurrent seizures are considered to have epilepsy.

Believe it or not, seizures have been found associated with a stroke, a closed head injury, an infection such as meningitis or another illness.

However, most cases of seizure have unknown causes.

The most common symptoms of seizure are temporary confusion, uncontrollable jerking movements of the arms and legs, loss of consciousness or awareness and cognitive or emotional symptoms, such as fear, and anxiety.

The seizure has also been found to induce complications such as failing, car accidents due to loss control, pregnancy complications, and emotional health problems such as depression and anxiety.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of symptoms of epilepsy, researchers examined the effect of Tocotrienol activity on seizure-triggered maladaptive neural plasticity and neuroinflammation that occur during the latent period as a key underlying event in epilepsy chronicization.

According to the analysis, α-tocopherol (α-T) reduced hippocampal neuroglial activation and neurodegeneration in the rat model of kainic acid (KA)-induced status epilepticus (SE).

Furthermore, α-T-treated epileptic rats, * showed to increase the number of population spikes elicited by pyramidal neurons, and recovered the latency to the onset of epileptiform-like network activity compared to control levels; (

* Prevented the neuronal death.

* Protected the blood-brain barrier protein by fully reversed the decrease of claudin,

* Inhibited the expression of pro-inflammatory cytokines and exhibited anti-inflammatory cytokines against neuroinflammation.

* Modulated the Genes associated with blood cell development in the hippocampus

Collectively, researchers said, "These findings support the potential of a timely intervention with α-T in the clinical management of SE to reduce epileptogenesis, thus preventing chronic epilepsy development".

Taken altogether, tocopherols may be considered a supplement or improvement of bone collagen formation against the risk of osteoporosis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Neurobiological Correlates of Alpha-Tocopherol Antiepileptogenic Effects and MicroRNA Expression Modulation in a Rat Model of Kainate-Induced Seizures by Ambrogini P1, Albertini MC2, Betti M2, Galati C2, Lattanzi D2, Savelli D2, Di Palma M2, Saccomanno S3, Bartolini D4, Torquato P4, Ruffolo G5, Olivieri F6,7, Galli F4, Palma E5, Minelli A2, Cuppini R. (PubMed)