Black Bean, The Legume That Suppresses the Early Onset of Liver Fibrosis

By Kyle J. Norton, Master of Nutrition


Black or common bean may be potential function food used to suppress the progression of liver
fibrosis and protect the liver against the onset of the disease, researchers suggested.

Liver fibrosis is a medical condition characterized by advanced liver scars that take over most tissue of the liver organ, causing liver inability to perform its normal function.

In compared to cirrhosis, liver fibrosis is a moderate case of liver disease.

The disease is caused by infection of hepatitis virus. However, not all people with the virus will develop 

liver fibrosis.

Since liver fibrosis is a very slowly progressive disease, people who carry the disease may not experience any symptoms until the advanced stage.

Truly, people who consume excessive alcohol and carry the hepatitis virus may not develop the diseases until their later life.

Some researchers suggested that besides the hepatitis virus, liver fibrosis can also be caused by the accumulation of toxins that take years to damages the liver such as excessive alcohol intake,.environment toxins, liver injury,......and a medical condition such as alcoholic liver disease, nonalcoholic liver disease, biliary obstruction,.. and iron overload.

Symptoms of liver fibrosis include appetite loss, difficulty thinking clearly, fluid in the abdomen, bleeding in the intestines, unexplained weight loss, weakness,..... and poor blood clotting.

According to a statistic from John Hopskin Medicine(2), 

* Cirrhosis and other chronic liver diseases are common disease-related causes of death in the U.S. Approximately 31,000 people in the U.S. die each year from cirrhosis.

* Approximately 3.5 to 4.6 million people in the U.S. are chronically infected with the hepatitis C virus. About 2,000 people die of hepatitis C annually in the U.S.

And,

* Hepatitis B kills approximately 2,000 people in the U.S. annually, and 85,000 to 2.2 million people in the U.S. are infected with the virus.

Black bean, small roughly ovoid legumes with glossy black shells, genus Phaseolus, belongings to the family Fabaceae, first domesticated growth in South America.

The black legume can be bought in most grocery stores all around the year in dried and canned forms.

According to the Tecnológico de Monterrey, School of Medicine, Basic Research Laboratory, oral administrated black bean extract exerted a significantly decreased type I and type IV collagen gene expression(1).

Type I and type IV collagen were associated to the early event in the development of hepatic fibrosis, particularly, in the early marked increase in the mRNA for type IV collagen. (3).

In eight weeks of carbon tetrachloride (CCl4) induced liver injury in a rat model, black bean extract of 70 mg/kg treatment showed a reduced hepatic fibrosis index by 18% in compared to positive controls(1).

The study also indicated that the efficacy of black bean extract in ameliorated risk of liver fibrosis due to injury may be attributed to legume strong antifibrotic compounds that inhibit the increased inflammatory and oxidative burst in liver fibrosis(1).

Furthermore, in the application of 0.1 g of crude biomass obtained from seed coats of Perla black bean dissolved in 400 mL of H2 O,, and 100 g of NaCl added in liver injury mice model, back bean treatment in both group expressed evidence of improvement of pathological changes, including interstitial fibrosis, inflammatory infiltration, collagen deposition and steatosis in compared to normal group(1).

Histological analysis showed that the test group presented a significant reduction of collagen deposition of which exhibited a reduced risk of developed liver scaring in the recovery phase (1).

Antioxidant effect against liver intoxication, a widely used laboratory application in induced lipid peroxidation and trichloromethyl radical (CCl3 ), to cause severe liver cell damage in an animal model, may represent a new perspective in liver injury and fibrosis prevention, the researcher concluded.

Taking together, black bean, contains various phytochemicals, such as naringenin, Nacetylcysteine, vitamin E, silymarin, quercetin in exhibited antioxidant activity, may be considered as an integrated form of diet therapy for liver protection and suppressing liver fibrosis.

However, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of black bean anti-liver fibrosis possibilities.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Black bean extract ameliorates liver fibrosis in rats with CCl4-induced injury by López-Reyes AG1, Arroyo-Curras N, Cano BG, Lara-Díaz VJ, Guajardo-Salinas GE, Islas JF, Morales-Oyarvide V, Morales-Garza LA, Galvez-Gastelum FJ, Grijalva G, Moreno-Cuevas JE. (PubMed)(Annals of Hepatology)
(2) Liver Disease Statistics by John Hopskin Medicine
(3) Gene expression of type I, III and IV collagens in hepatic fibrosis induced by dimethylnitrosamine in the rat by L Ala-Kokko, T Pihlajaniemi, J C Myers, K I Kivirikko, and E R Savolainen(PMC)