How To Treat Inflammatory Diseases Effectively and Naturally, PubMed Studies Suggestions

Arnica essential oil and major phytochemicals may have a therapeutic effect in reduced inflammation though skin penetration, some scientists suggested.

The results of these investigation were carried out by some respectable institutes, including the Albert-Ludwigs-University Freiburg.

You can view the article as the differentiation were published on some online literature, including public medical library.

Inflamamtion is a natural reaction of immune response to protect the damage or injure tissue against foreign invasion.

However, over production of pro inflammatory cytokines may induce normal cell deaths and forming of scars.

Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, native to Europe and Asia, used in herbal medicine for centuries to treat strains, sprains, and bruises.
Wound healing is process of repairing after damage of skin, tissues, organs, etc.


The ingredients
Helenalin, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivative.

In inflammatory diseases, topical of Arinca preparation exerted a significantly anti inflammatory activity through skin penetration of sesquiterpene lactones (SLs) from the helenalin and 11alpha,13-dihydrohelenalin, the major bioactive compound found in the herb.

Sesquiterpene lactones (SLs) isolated from Arnica, according to a gas chromatography/mass spectrometry method in tested subjects, in investigation of penetration behaviour of one gel preparation and two ointment preparations demonstrated the comparable penetration through the stratum corneum, the uppermost part of the skin. 

These results suggested that the bioactive compound induced efficacy by injecting its effectiveness through the horny outer layer of the skin in inhibited the production of anti inflammatory cytokines without ameliorating the immune response to the site of infection.

Levels of sesquiterpene lactones (SLs) was slowly decrease, 4 hours after injection in compared to penetration rate of ointments kept constant over time. 

Dr. Wagner S, the lead author, after taking into account of other co and con factors said, "the totally penetrated amount of SLs only depends on the kind of the formulation and of the SLs-content in the formulation but not on the SLs composition or on the used extraction agent".

Further testing the anti inflammatory property of Sesquiterpene lactones (SLs) islated fron Arnica, researchers at the Albert-Ludwigs-Universität Freiburg conducted an investigation, using some alcoholic preparations of fresh Arnica flowers and an Arnica fresh plant gel.

The stripping method with adhesive tape and pig skin were used as a model to determine the quantity of SLs in the stripped layers of the stratum corneum (SC). 

According to the observation, application of isolated SLs permeated through the SC in a very small amount, in compared to permeation of SLs much higher when they were present in the tinctures.

Tested Arnica preparations of fresh Arnica flowers with two preparations showed the best penetration behaviour of all the tested substances.

These conclusion suggested that all preparations reconfirm the efficacy of Arnica in attenuated over expression of inflammation induced by immune  response and some preparations consisted a better anti inflammatory effect than others. 

Dr. Wagner S, the lead scientists once again said, "a sufficient amount of SLs might permeate the skin barrier by using Arnica preparations to exert anti-inflammatory effects and that the topical use of plant preparations may be advantageous compared to the isolated compounds".

Interestingly, in the analysis of SLs therapeutic relevance as single components for the local treatment of inflammation, Dr. Merfort I suggested that " SLs may be favourable in dual therapy or in the inhibition of leukaemia cell growth" and "native SLs serve as leads that have to be optimised in terms of their specificity, pharmacokinetics and absorption, distribution, metabolism and excretion (=ADME) properties".

Taken together, herbal Arnica and Its bioactive compound, particularly sesquiterpene lactones (SLs) may be used alone as a topical substance or combination with conventional medicine for treatment of all forms of  inflammatory diseases.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Skin penetration behaviour of sesquiterpene lactones from different Arnica preparations using a validated GC-MSD method by Wagner S1, Merfort I.(PubMed)
(2) Skin penetration studies of Arnica preparations and of their sesquiterpene lactones by Wagner S1, Suter A, Merfort I.(PubMed)
(3) Perspectives on sesquiterpene lactones in inflammation and cancer by Merfort I(PubMed)