Herbal Therapy: Cat's Claw, the Best Whole Herb medicine for Prevention and Treatment of Colorectal cancer

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Whole food(herbal medicine) used as medical treatment,  linking health benefits in prevention, management and treatment of diseases has induced much interests in today renowned scientists.

Many researchers has raised question of quality of the herbs because geographic differences, time of grown and harvest, etc. may effect their's potency. I do believe, these questions can only be answered by experience herbalists.

Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae, used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc..

The chemical constituents of Cat's claw include, ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine, etc.

Bowel cancer also known as colorectal cancer, is a condition of the abnormal proliferation of cells in the colon, rectum, or vermiform appendix. Bowl is divided in 2 parts, the first part of the bowel, the small bowl, is involved with the digestion and absorption of food. The 2nd part, the large bowel which consist the the colon and rectum, is involved in absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be re absorbed and reused by the body. Bowel cancer is relatively very common and slowly growing and progress cancer and in predictable way.
Bowel cancer is the third most commonly diagnosed cancer in developed countries, including U>S and Canada.

Cat's Claw extract may have a role for cancer patients as a complementary therapy. According to the joint study lead by the Federal University of Santa Maria (UFSM), Cat's Claw enhanced chemotherapy-induced apoptosis, with an interference in cell cycle division in colorectal adenocarcinoma cells (HT29 cells).

Dr. Gurrola-Díaz CM, the lead researchers at the Centro Universitario de Ciencias de la Salud (CUCS) suggested, the anti-inflammatory and anti-proliferative properties of different alkaloids extracted from Cat's Claw may be resulted of the interfering the proteins that pass signals into a cell through cell surface receptors. Uncaria tomentosa is less toxic in non-cancer cells than in cancer cells.

In a randomized clinical trial conducted of Patients (43) undergoing adjuvant/palliative chemotherapy, patient received chemotherapy plus 300 mg of Uncaria tomentosa daily, showed to reduce side effects of chemotherapy with no toxic effect.

Dr. Valerio LG Jr and Dr. Gonzales GF. in the review of the toxicological aspects of the South American herbs cat's claw said, " An important finding unveiled by this review is the importance of standardisation in quality and additional basic and clinical research to scientifically validate and understand composition, biological activity, safety and risk" and " Development of a comprehensive pharmacological and toxicological profile through critical evaluation of existing and future experimental data... "

Therefore, the use of Cat's Claw as a whole herb medicine should be taken with care. The quantity intake can only be prescribed by professional; herbalists.

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Sources
(1) Contraceptive effect of Uncaria tomentosa (cat's claw) in rats with experimental endometriosis by Nogueira Neto J1, Cavalcante FL, Carvalho RA, Rodrigues TG, Xavier MS, Furtado PG, Schor E.(PubMed)
(2) Inhibitory mechanisms of two Uncaria tomentosa extracts affecting the Wnt-signaling pathway by Gurrola-Díaz CM1, García-López PM, Gulewicz K, Pilarski R, Dihlmann S.(PubMed)
(3) Uncaria tomentosa for Reducing Side Effects Caused by Chemotherapy in CRC Patients: Clinical Trial by Farias IL1, Araújo MC, Farias JG, Rossato LV, Elsenbach LI, Dalmora SL, Flores NM, Durigon M, Cruz IB, Morsch VM, Schetinger MR.(PubMed)
(4) Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii) : a critical synopsis by Valerio LG Jr1, Gonzales GF.(PubMed)