Kyle J. Norton
Ovarian cancer is defined as
a condition of abnormal cells growth of ovaries. It is
one of most common cancer in US, according to the statistics adapted
from the American Cancer Society's publication, Cancer Facts &
Figures 2010, an estimated 21,880 women in the United States will be
diagnosed with ovarian cancer and 13,850 deaths.
Depending to the
stage and grade of the cancer, chemotherapy such as cisplatin,
carboplatin, paclitaxel, liposomal doxorubicin may be necessary to
prevent the spread and recurrence of the cancer. Epidemiological studies
focusing in vegetables and fruits in reduced risk and treatment of
ovarian cancer have not been conclusive(a)(b)(c)(d), some vitamins have showed
to inhibit the progression of cancer with little or no side effects.
Vitamin B6, also known as pyridoxine, is a water soluble vitamin found
abundantly in green peas, yams, broccoli, asparagus and turnip
greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish
etc., with functions of amino acid, carbohydrate metabolism, brain
health, and liver detoxification, etc.
Epidemiological studies, linking vitamin B6 in reduced risk of ovarian cancer have been inconsistent.
The study of the Brigham and Women's Hospital, Boston, indicated that intake of one-carbon metabolism related nutrients, especially vitamin B(6) and methionine, may lower ovarian cancer risk (1). In 80,254
Nurses' Health Study participants, during 22 years of follow-up
(1980-2002), researchers found little evidence to support dietary
folate, methionine, and vitamin B(6) in related ovarian cancer risk(2), But
in the study to compare the effectiveness of acupuncture plus vitamin B6 PC6 points injection of 142 patients, between March 1, 2006, and June 30,
2008 indicated that acupuncture plus vitamin B6 PC6 points injection relieved nausea and vomiting in patients with ovarian cancer, undergoing a highly emetogenic chemotherapy regimen(3). In a total of 248 analyzable patients with Stages III-IV ovarian epithelial cancer (114 with and 134 without prior chemotherapy) conducted by the Albert Einstein Cancer Center, showed that although administration of pyridoxine significantly
reduced neurotoxicity, its
adverse effect on response duration suggests that the agent should not
be administered with cisplatin (DDP) and hexamethylmelamine (HMM)
regimens(4). In the assessed dietary intakes and factors associated with
diet in women with family history of breast and/or ovarian cancer (FHBOC) study, suggest that women with FHBOC should be encouraged to meet dietary guidelines for cancer prevention, including intake of vitamin B6(5).
Taking altogether, vitamin B6 may be associated to reduced risk and
treatment of ovarian cancer when it is used in conjunction with
acupuncture, but further study with large sample and multi center
studies are necessary to improve the validation. Over doses may induced
the symptoms
of difficulty coordinating movement, numbness, sensory changes, etc.,
please make sure you follow the guideline of the Institute of Medicine
of the National Academies.
Ovarian Cysts And PCOS Elimination
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References
(a) Fruit and vegetable consumption and risk of epithelial ovarian cancer: the European Prospective Investigation into Cancer and Nutrition by Schulz M1,
Lahmann PH, Boeing H, Hoffmann K, Allen N, Key TJ, Bingham S, Wirfält
E, Berglund G, Lundin E, Hallmans G, Lukanova A, Martínez Garcia C,
González CA, Tormo MJ, Quirós JR, Ardanaz E, Larrañaga N, Lund E, Gram
IT, Skeie G, Peeters PH, van Gils CH, Bueno-de-Mesquita HB, Büchner FL,
Pasanisi P, Galasso R, Palli D, Tumino R, Vineis P, Trichopoulou A,
Kalapothaki V, Trichopoulos D, Chang-Claude J, Linseisen J,
Boutron-Ruault MC, Touillaud M, Clavel-Chapelon F, Olsen A, Tjønneland
A, Overvad K, Tetsche M, Jenab M, Norat T, Kaaks R, Riboli E.(PubMed)
(b) Fruits and vegetables and ovarian cancer risk in a pooled analysis of 12 cohort studies by Koushik A1,
Hunter DJ, Spiegelman D, Anderson KE, Arslan AA, Beeson WL, van den
Brandt PA, Buring JE, Cerhan JR, Colditz GA, Fraser GE, Freudenheim JL,
Genkinger JM, Goldbohm RA, Hankinson SE, Koenig KL, Larsson SC,
Leitzmann M, McCullough ML, Miller AB, Patel A, Rohan TE, Schatzkin A,
Smit E, Willett WC, Wolk A, Zhang SM, Smith-Warner SA(PubMed).
(c) Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk by Riboli E1, Norat T.(PubMed)
(d) Risk of ovarian carcinoma and consumption of vitamins A, C, and E and specific carotenoids: a prospective analysis by Fairfield KM1, Hankinson SE, Rosner BA, Hunter DJ, Colditz GA, Willett WC.(PubMed)
(1)Folate, vitamin B(6) , vitamin B(12) , methionine and alcohol intake in relation to ovarian cancer risk by Harris HR1, Cramer DW, Vitonis AF, DePari M, Terry KL.(PubMed)
(2) Intake of folate and related nutrients in relation to risk of epithelial ovarian cancer by Tworoger SS1, Hecht JL, Giovannucci E, Hankinson SE.(PubMed)
(3) Vitamin B6 points PC6 injection during acupuncture can relieve nausea and vomiting in patients with ovarian cancer by You Q1, Yu H, Wu D, Zhang Y, Zheng J, Peng C.(PubMed)
(4) Hexamethylmelamine and low or moderate dose cisplatin with or without pyridoxine for treatment of advanced ovarian carcinoma: a study of the Eastern Cooperative Oncology Group by Wiernik PH1, Yeap B, Vogl SE, Kaplan BH, Comis RL, Falkson G, Davis TE, Fazzini E, Cheuvart B, Horton J.(PubMed)
(5) Diet and predictors of dietary intakes in women with family history of breast and/or ovarian cancer by McEligot AJ1, Mouttapa M, Ziogas A, Anton-Culver H.(PubMed)
Health Researcher and Article Writer. Expert in Health Benefits of Foods, Herbs, and Phytochemicals. Master in Mathematics & Nutrition and BA in World Literature and Literary criticism. All articles written by Kyle J. Norton are for information & education only.
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