Anacardic acids are phenolic lipids, phytochemicals of the organic acid found abundantly in cashews, mangoes, etc.
Lung cancer is defined as a condition of the abnormal
growth of the cells in the lung's tissue. Most common form of primary
lung cancers are derived from epithelial cells. In Us, Lung cancer is
the leading cause of cancer deaths, causing 158,683 people deaths,
including 88,329 men and 70,354 women, according to 2007 statistic.
The health benefits
Anacardic acid (AA), a chemical conpound
found in some foods and herb has exerted its cytotoxicity property to
causes cell on A549 lung adenocarcinoma cells through the activation of
mitochondrial-mediated involved in initiating a caspase-independent
pathway and an contact activation pathway executioner such as cytochrome
c. The phytochemical on the other hand also expresses its
anticancer, anti-inflammatory, and
radiosensitization through suppresion of a protein complex that controls
transcription of DNA, the NF-kappaB signalling pathway. These results
may demonstrate a novel role for anacardic acid in potentially preventing or treating cancer through modulation of certain pathways.
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References
(1) Anacardic acid induces
mitochondrial-mediated apoptosis in the A549 human lung
adenocarcinoma cells by Seong YA, Shin PG, Kim GD.(PubMed)
(2) Anacardic acid (6-nonadecyl salicylic
acid), an inhibitor of histone acetyltransferase, suppresses expression
of nuclear factor-kappaB-regulated gene products involved in cell
survival, proliferation, invasion, and inflammation through inhibition
of the inhibitory subunit of nuclear factor-kappaBalpha kinase, leading
to potentiation of apoptosis by Sung B, Pandey MK, Ahn KS, Yi T,
Chaturvedi MM, Liu M, Aggarwal BB.(PubMed)
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