Cascara sagrada is a species of buckthorn, genus Rhamnus,
belonging to the family Rhamnaceae, native to western North America,
it's bark has been used in traditional medicine for gastrointestinal
support. and it is thought to have a laxative and natural cleansing, etc., effect.
Rhinoviruses
are viral infective agents in humans, associated to the cause of the common cold
The ingredients
Beside
the main compound of anthraquinones, otyher compounds include
anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin,
and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides
A, B, C, and D, and hydroxy anthracene derivatives (HAD), etc.
The effects
Mitoxantrone, a anthraquinone derivative
found in Cascara Sagrada may be the next potential agent in treating
severe asthma caused the Rhinoviruses. It is known that severe asthma is
associated the immune response to infection and inflammation and a
family of enzymes involved in cellular functions (PI3K). In the study of
the effects of Mitoxantrone allergic mice infected with RV1B, showed
an effective potential in RV-induced asthma by blocking pro-inflammatory
pathways regulated by multiple cellular processes of PI3K.
The effect of the herb may be more profound as the chemical constituent
of emodin showed a significantly anti inflammatory activity with
capable of interacting with several major inflammatory molecular
targets. The result re-emphasizes its potential therapeutic role in the
treatment of inflammatory diseases.
The Side effects
1. Cascara Sagrada can be liver toxic.
2. It may cause Postal hypertension
Cascara sagrada (CS) has been associated with the development of cholestatic hepatitis, complicated by portal hypertension.
3. Fresh cut, dried bark may cause vomiting and diarrhea.
4. It may allergic effect.
5. Etc.
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References
(1) Targeted abrogation of diverse signal transduction cascades by
emodin for the treatment of inflammatory disorders and cancer by
Shrimali D, Shanmugam MK, Kumar AP, Zhang J, Tan BK, Ahn KS, Sethi G.(PubMed)
(2) Inhibiting AKT Phosphorylation Employing Non-Cytotoxic Anthraquinones Ameliorates TH2 Mediated Allergic Airways Disease
and Rhinovirus Exacerbation by Cesar de Souza Alves C, Collison A,
Hatchwell L, Plank M, Morten M, Foster PS, Johnston SL, França da Costa
C, Vieira de Almeida M, Couto Teixeira H, Paula Ferreira A, Mattes J.(PubMed)
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