Antioxidant Sinigrin Isolated From Brussel Sprouts, Broccoli,... May Be The Potential Anti Atherosclerosis Chemical Compound, According to Studies

By Kyle J. Norton

Sinigrin may be used as a bioactive ingredient for the prevention and treatment of atherosclerosis, according to studies.

Atherosclerosis is a medical condition caused by plaques accumulated on the wall of the arteries, leading to narrowing the arteries in transporting oxygenated blood to the heart and other parts of the body.

Depending on the blood obstruction, atherosclerosis can induce different types of heart disease and stroke.

Plaque is made of cholesterols, calcium, and other toxic substances, including cadmium.

According to the statistics provided by Atherosclerosis Open Acess, 32% of deaths account for atherosclerosis. 13.8% prevalence is among adults of 20 years and above. In 2010, the coronary heart disease mortality rate was about 60%.



Risk factors of atherosclerosis include high blood pressure and cholesterol, diabetes, being overweight or obese, unhealthy diet, family history of heart disease and physical inactivity, particularly smoking.


Some researchers suggested that since cholesterol makes up a big part of the plaque, an unhealthy diet with a high saturated trans fat, red meat, and processed meat may be the major cause of atherosclerosis.


In other words, the Western diet is one of the major culprits that cause the majority of cases of atherosclerosis.


Dr. Meifang Wang, the lead researcher in the study of "Western Diet Increases Inflammatory Responses and Atherosclerosis Progression via IGF-1 Receptor in ApoE-Deficient Mice" said, "....lowered circulating IGF-1 increases atherosclerosis progression in atherosclerosis-prone apolipoprotein E-deficient mice (ApoE−/−) while increased circulating IGF-1 downregulates vascular pro-inflammatory cytokine gene expression, reduces systemic and vascular oxidant stress, vascular cytokine expression, and decreases atherosclerosis progression".

And, "the pro-inflammatory phenotype that is enhanced by WD in ApoE−/− mice is further enhanced by specific IGF1R deficiency in monocytes/macrophages, and may consequently increase atherosclerosis progression".


The results suggested that the Western diet-induced atherosclerosis progression through the increase of production of pro-inflammatory cytokines and decrease of the function of insulin-like growth factor-1 (IGF-1) as a mediator of anabolic responses in many cells and tissues.


Sinigrin is a phytochemical glucosinolate, belonging to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.

Scientists on finding a natural bioactive compound for the treatment of atherosclerosis examined the effect of sinigrin against plaque accumulation on the arterial walls.

On atherosclerosis in ApoE-/- mice, injection sinigrin exerted a significant effect in the inhibition of the serum concentrations of lactate dehydrogenase (LDH), triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), calcium (Ca2+), and pro-inflammatory cytokines associated with plaque accumulated on the wall of the arteries.


Furthermore, oral administration of sinigrin attenuated the mRNA expression of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), which form a part of immunoglobulin superfamily in inflammatory and immune responses.

Moreover, injection also reduced the expression of genes C-C motif chemokine ligand 2 (CCL2), and CCL5 on aorta tissues associated with the risk of atherosclerosis.

The expression of low-density lipoprotein was also reduced by the injection of sinigrin observed by some keys regulators of cholesterol such as sterol regulatory element-binding protein-2 (SREBP-2).


Interestingly, increasing the concentration of sinigrin at the dose up to 100 μg/ml also significantly suppressed the levels of Tumor necrosis factor (TNF-α) and nuclear translocation of NF-κB, cell signaling protein (cytokine) involved in systemic inflammation.


Additionally, at a contraction ut to 100 μg/ml, sinigrin inhibited the c-Jun-NH (2)-terminal kinase (JNK) signaling pathway which plays a critical role in regulating cellular differentiation.

The findings strongly suggested that sinigrin inhibited the onset of atherosclerosis by lowering the low-density lipoproteins and mechanisms associated with inflammatory induction of plaque accumulation on the arterial wall.

Dr. Jang YJ, the lead scientist wrote, "sinigrin decreases the TNF-α-stimulated VCAM-1 expression through the suppression of NF-κB and MAP kinases signaling pathways, Overall, sinigrin has the potential to be used in reducing the risks of atherosclerosis".

Taken altogether, sinigrin may be considered a supplement for the prevention and combined with the primary therapy for the treatment of atherosclerosis, pending the confirmation of a larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professional's Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sinigrin attenuates the progression of atherosclerosis in ApoE-/- mice fed a high-cholesterol diet potentially by inhibiting VCAM-1 expression by Jang YJ1, Park B1, Lee HW1, Park HJ1, Koo HJ2, Kim BO3, Sohn EH4, Um SH5, Pyo S. (PubMed)
(2) Western Diet Increases Inflammatory Responses and Atherosclerosis Progression via IGF-1 Receptor in ApoE-Deficient Mice by Meifang Wang, Yusuke Higashi, Derek Wang, Ronald Korthuis, and Patrice Delafontaine. (FASEB Journal)

Phytochemical Beta-Sitosterol Inhibits the Risk and Treatment of Colon Cancer in Vitro and Vivo

By Kyle J. Norton

The colon-formed parts of the secretory system are also known as the large bowel or large intestine with a function to reabsorb fluids and process and secret waste products from the body.

Cancer is a class of chronic diseases caused by cell growth disorderly and irregularly in the tissue of a specific organ as a result of the alternation of DNA.

Colon cancer is a chronic condition caused by cell growth irregularly and disorderly in the colon due to the alternation of DNA.

Colon cancer is one most slow-growing cancer compared to other cancers. In some patients, colon cancer may exist in the colon more than 20 years before it is discovered. Therefore, only 39% of colon cancer is diagnosed in the early stage, which orchestrates more incidences of death compared to other cancers.

Most cases of colon cancer start in the cells on the surface of the inner lining of the colon. At this stage, patients may not experience any symptoms.

After penetrating deeper into the colon layer, the cancer cells may travel a distance away to infect other healthy tissue and organs through the fluids and blood circulation.

At this stage, the increased size of the tumor may suppress the nearby tissue, organs, or nerve cells causing localized symptoms and severe pain.

According to the statistic provided by the American Cancer Society, in 2019, approximately, 101,420 new cases of colon cancer will be diagnosed. Colon cancer also causes the death of 51,020 deaths. during 2019.

The lifetime risk associated with the onset of colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.

The median age diagnosed with colon cancer is 68 in men and 72 in women compared to the age of 63 for rectal cancer in both men and women.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belonging to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.


On finding a potential phytochemical for the treatment of malignant tumors, researchers examined the protective effect of beta-sitosterol isolated from A. curassavica against colon cancer in Vitro and Vivo.

The study included male Wistar rats injected with 1,2-dimethylhydrazine (DMH, 20 mg/kg b.w.) and supplemented with beta-sitosterol throughout the experimental period of 16 weeks at 5, 10, and 20 mg/kg b.w.

According to the tested analysis, beta-sitosterol induced significant growth inhibition of COLO 320 in a dose-dependent manner.

Beta-sitosterol supplementation also reduced the number of aberrant crypt and crypt multiplicity in DMH-initiated rats in a dose-dependent manner without inducing toxicity. 

Additionally, the application of 10-20 mg/kg b.w. of beta-sitosterol not only is effective in vivo but also induced chemopreventive potential by inhibiting the expression of free radicals in vitro, with minimal toxicity to normal cells.

Based on the findings, researchers said, " It (Beta-sitosterol) also attenuated beta-catenin and PCNA expression, making it a potential anticancer drug for colon carcinogenesis".

Taken altogether, beta-Sitosterol may be considered a functional food for the prevention and treatment of colon cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Chemopreventive potential of beta-Sitosterol in experimental colon cancer model--an in vitro and In vivo study by Baskar AA1, Ignacimuthu S, Paulraj GM, Al Numair KS. (PubMed)

Beetroot's Betanin Enhances the Effects of Chemotherapy In Vitros

By Kyle J. Norton

Chemotherapy is an action in which a substance including drugs was used to treat any disease, particularly, cancer.

In cancers, chemotherapy is a treatment to kill or damage cancer cells in a specific area. Besides chemotherapy, the most common treatment for cancer in conventional medicine are surgery and radiation, depending on the severity of the condition.


The aim of chemotherapy is to cure or control the progression of cancer and improve the quality of life of patients by reducing symptoms.


In other words, chemotherapy is effective to shrink a tumor before surgery or kill the remaining cancer cells that cannot completely be removed by radiation and surgery.

Depending on the type and stage and grade of cancer, treatment may be a single chemo drug or several drugs.

Chemotherapy has been found to induce serious side effects, including fatigue. hair loss, easy bruising and bleeding, infection, anemia, nausea and vomiting, and constipation due to its nature to kill cells (cancer and healthy cells) indiscriminatingly.

Betanin is a phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

Researchers with an aim to discover a natural compound or whole food which enhances chemotherapy in the treatment of cancer examined the effects of betanin (BET) co-administration with the potent anticancer drugs e.g. doxorubicin (DOX) in reducing the side effects.

The study included the introduction of a new pH-responsive nanocarrier via decoration of gelatin nanoparticles (GNPs) by (methoxy poly (ethylene glycol)-poly ((2-dimethylamino) ethyl methacrylate-co-itaconic acid) (PGNPs) loaded with 20.5 % of DOX and 16.25of BET that overcomes the restrictions of BET and provides the synergistic effect of DOX@BET.

At the adjusting of the pH of the environment, the stimulated release of DOX and BET from PGNPs showed a significant synergistic effect of DOX@BET not only inhibited the tested cancer cell line MCF-7 but also the side effect caused by DOX.


In other words, the betanin enhanced chemo drug efficacy and inhibited the treatment of drug toxicity.


Based on the findings, Dr. Amjadi S, the lead scientist said, "(The synergistic effect of DOX@BET may contribute to the) developed smart nanocarrier will be a hopeful nanocarrier for cancer therapy".

In order to find out more information about the enhanced chemotherapy researchers investigated the activity of extract of red beetroot (Beta vulgaris L.), the FDA approved red food color E162 with an anticancer drug, doxorubicin (adriamycin) in human prostate cancer cells (PC-3) and estrogen receptor-positive human breast cancer cells (MCF-7).

Individual treatment of doxorubicin and the beetroot extract exhibited a cytotoxic effect in the two tested cancer cell lines in a dose-dependent manner.

The cytotoxicity induced by beetroot extract at the concentration of 29 µg/ml was significantly lower compared to doxorubicin.

Beetroot extract inhibited the cancer proliferation at a trend of gradual decrease of the growth rate of the PC-3 cells (3.7% in 3 days vs. 12.5% in 7 days) compared to doxorubicin completely inhibited the growth of the PC-3 cells in three days at the same concentration level.

In the additional differentiation of the results, researchers found that the cytotoxicity exhibited by the red beetroot extract is attributed to the effects of betanin, the major betacyanin constituent.

Based on the findings, betanin co-administration with chemo drug not only have a profound effect in enhancing the function of the anti-cancer drug but also reduce the side effect induced by conventional medicine.

Taken altogether, betanin used alone or combined with other chemo drugs may be considered medicine for the treatment of cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of betanin in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A novel smart PEGylated gelatin nanoparticle for co-delivery of doxorubicin and betanin: A strategy for enhancing the therapeutic efficacy of chemotherapy by Amjadi S1, Hamishehkar H2, Ghorbani M. (PubMed)
(2) Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancercell lines by Kapadia GJ1, Azuine MA, Rao GS, Arai T, Iida A, Tokuda H. (PubMed)

Phytochemical Tocopherols Have No Effects on Platelet Aggregation in Patients with Metabolic Syndrome

By Kyle J. Norton

A metabolic syndrome is a group of conditions associated with an increased risk of cardiovascular disease and type 2 diabetes, including high blood pressure, sugar, cholesterol, triglyceride levels, and excess body fat around the waist.

Epidemiological studies suggested if you have 3 of the above syndromes you have metabolic syndrome.

According to statistics, in the US, 30% of Americans are living with metabolic syndrome,

and, 1 in 5 people in Canada has metabolic syndrome, affecting 19.1% of all Canadian adults.

The CDC statistic suggested, that among US adults aged 18 years or older, the prevalence of metabolic syndrome rose by more than 35% from 25.3% to 34.2% according to the data from 1988–1994 to 2007–2012.

There are certain risk factors associated with the onset of metabolic syndrome besides the five mentioned above including age, family history of metabolic syndrome, physical activity, and women diagnosed with polycystic ovary syndrome.

Untreated metabolic syndrome epidemiologically may induce complications of chronic illness such as atherosclerosis, nonalcoholic fatty liver disease, and kidney diseases.

Platelet aggregation is a condition of platelets clumping together in the blood. The process also is necessary for the cover of vascular injury.

Tocopherols are phytochemicals of which many have vitamin E activity, belongings to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of cardiovascular diseases and diabetes, researchers examined the effect of palm-based tocotrienols and tocopherol (PTT) mixture supplementation on platelet aggregation reactivity. 

A randomized, double-blind, crossover, and the placebo-controlled trial included 32 metabolic syndrome adults supplemented with 200 mg (69% tocotrienols and 31% α-tocopherol) twice daily of PTT mixture or placebo capsules for 14 days and consumed 200 mg PTT mixture or placebo capsule after a meal, after 14 days,  after15-day washout period.

Fasting platelet aggregation reactivity stimulated with adenosine diphosphate (ADP) which is essential to the flow of energy in living cells, did not show substantial changes after supplementation with PTT mixture compared to placebo.

There are no changes in postprandial platelet aggregation reactivity compared to PTT mixture and placebo interventions.

Based on the findings, researchers said, "The results of this study highlight the lack of inhibitory effect on platelet aggregation after short-term supplementation of PTT mixture in participants with metabolic syndrome".

Taken altogether, tocopherols have no effect on platelet aggregation in patients with metabolic syndrome, pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of palm-based tocotrienols and tocopherol mixture supplementation on platelet aggregation in subjects with metabolic syndrome: a randomised controlled trial by Gan YL1,2, Fu JY3, Lai OM1,4, Chew BH5, Yuen KH6, Teng KT2, Nesaretnam K2, Selvaduray KR2, Meganathan P. (PubMed)

Pungent Spice Onions Suppress Weight Gain in Obese Animals in Vivos

By Kyle J. Norton

Obesity is a medical and chronic condition caused by long-term excessive body fat accumulated. Overweight is a condition of excess body weight relative to height.

According to the Body Mass Index(BMI), people who have a BMI between 25 to 29.9 are considered overweight and a BMI of over 30 is an indication of obesity.

The formula of the BMI indexBMI= weight (kg)/ height (m2)

According to the statistic, 68% of the American population is either overweight or obese. However,
in 2016, more than 1.9 billion adults, 18 years and older, were overweight, including over 650 million were obese worldwide.

The most common causes of obesity are associated with
* An increased intake of energy-dense foods that are high in saturated and trans fat, processed foods, and red meat.

* An increase in physical inactivity.

The WHO in the explanation of the causes of obesity wrote, "Changes in dietary and physical activity patterns are often the result of environmental and societal changes associated with the development and lack of supportive policies in sectors such as health, agriculture, transport, urban planning, environment, food processing, distribution, marketing, and education".

Certain medical conditions such as hypothyroidism, polycystic ovary syndrome, Cushing's syndrome,..., genetic preposition, and the use of certain medications that can cause weight gain or water retention, such as corticosteroids, antidepressants, or some seizure medications, also increases the risk of overweight and obesity.

Epidemiologically, obese people are associated with an increased risk of diseases and health problems, including heart disease, diabetes, and high blood pressure.

Some researchers suggested that dietary changes, increased physical activity, and behavior changes have been found to enhance weight loss in obesity. In extremely obese subjects, prescription medications and weight-loss surgery may be the only options.

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation to garlic. It is often called the "king of vegetables" because of its pungent taste and is found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.

On finding a potential compound for the treatment of obesity, researchers examined the effects of
garlic oil and onion oil on serum lipid levels in hyperlipidemia in an animal model.

The study included 96 Sprague-Dawley rats randomly allocated into eight groups that received repeated oral administration of volatile oils extracted from garlic and onion for 60 days, based on their body weight and serum levels of triglycerides (TG) and total cholesterol (TC).

According to the tested assays compared to the baseline, the volatile oils of garlic and onion suppressed weight gain induced by HFD accompanied by the decrease of adipose tissue weight.

The decreased levels of TG, TC, and LDL-C and increased serum level of HDL-C were also found in the treatment group compared to rats in the hyperlipidemia model groups.

Furthermore, treatment with volatile oil also protects the liver against hepatic steatosis by improving the effects of the lipid profile.

In other words, volatile oils extracted from garlic and onion inhibit the risk of obesity by improving the liver and adipose tissue in fat metabolisms.

Dr. Yang C, the lead scientist after taking other factors into account wrote, "Our results implied that garlic oil and onion oil have anti-obesity properties that can counteract the effects of an HFD on body weight, adipose tissue weight, and serum lipid profiles".

Moreover, the assessment of the effect of onion peel tea (OPT) in a mouse model of high-fat-diet-induced obesity suggested that BALB/c mice fed a high-fat diet for three weeks, followed by a normal diet with or without OPT for 28 days suppresses the increases in body weight and level of epididymal fat tissue, similar to those of the aforementioned results.

Additionally, OPT administration also significantly reduced the serum concentrations of total cholesterol on day 14 and those of glucose and leptin on day 28.

These results suggested OPT inhibits the parameters associated with the onset of obesity.

Taken altogether, onion used alone or combined with garlic may be considered functional food/foods for the prevention and treatment of obesity, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-obesity and Hypolipidemic effects of garlic oil and onion oil in rats fed a high-fat diet by Yang C1, Li L1, Yang L1, Lǚ H1,2, Wang S1, Sun G. (PubMed)
(2) Onion peel tea ameliorates obesity and affects blood parameters in a mouse model of high-fat-diet-induced obesity by Matsunaga S1, Azuma K1, Watanabe M2, Tsuka T1, Imagawa T1, Osaki T1, Okamoto Y. (PubMed)
(3) Obesity and overweight by WHO

Turmeric Exerts Anti Hypertension Activity in Vivos

By Kyle J. Norton

High blood pressure or hypertension is a condition of abnormally high blood pressure in the arteries. Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.

High blood pressure is also a condition in the cluster of metabolic syndrome associated with the increased risk of cardiovascular disease (CVD), and diabetes.

Depending on the levels of blood pressure, most patients with high blood pressure are asymptomatic, However, long-term very high blood pressure has been found to induce dizziness and light head, shortness of breath, nosebleeds, flushing, chest pain, and visual changes.

Some medical conditions such as kidney disease and long-term stress are associated with high blood pressure.

According to the American hypertension Association, long-term untreated high blood pressure can induce complications that reduce or obstruct the function of the heart and blood vessels, leading to heart attack, stroke, and heart failure.

Conventional hypertensive medications have undoubtedly prevented many deaths from heart disease in the past 30 years, but they have many side effects.

If you are currently taking hypertensive medicine, please make sure you know all the side effects of the preventive measure.

Some researchers also found that excessive energy intake and obesity are major causes of hypertension.

Dr. Savica V, the lead author in the study "The effect of nutrition on blood pressure" wrote, "Obesity is associated with increased activity of the renin-angiotensin-aldosterone and sympathetic nervous systems, possibly other mineralocorticoid activity, insulin resistance, salt-sensitive hypertension, and excess salt intake, and reduced kidney function. High sodium chloride intake strongly predisposes to hypertension".

And, "Increased alcohol consumption may acutely elevate blood pressure. High intakes of potassium, polyunsaturated fatty acids, and protein, along with exercise and possibly vitamin D, may reduce blood pressure".

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.



The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.

On findings of a potential compound for the treatment of high blood pressure, researchers examined the effects of ginger (Zingiber officinale) and turmeric (Curcuma longa) on a hypertensive animal model.

Selected rats induced hypertension by oral administration of Nω-nitro-L-arginine methyl ester hydrochloride, 40 mg/kg body weight to the study were divided into seven groups (n = 10).
* The groups 1-3 included normotensive control rats, hypertensive (Nω-nitro-L-arginine methyl ester hydrochloride) rats, and hypertensive control rats treated with atenolol (an antihypertensive drug).

* Groups 4 and 5 included normotensive and hypertensive (Nω-nitro-L-arginine methyl ester hydrochloride) rats treated with 4 % supplementation of turmeric, respectively.

* Groups 6 and 7 included normotensive and hypertensive rats treated with 4 % supplementation of ginger, respectively.

During the experiment, researchers found that Nω-nitro-L-arginine methyl ester hydrochloride hypertensive rats showed a significant increase in ATP and ADP hydrolysis, adenosine deaminase involved in purine metabolism, and acetylcholinesterase involved in the regulation of blood vessel tone compared to the control rats.

In other words, the injection of Nω-nitro-L-arginine methyl ester hydrochloride causes the increase of enzymes associated with the constriction of blood vessel tone, blocking the blood vessel dilatation and blood flow through the coronary blood vessels.

Furthermore, Nω-nitro-L-arginine methyl ester hydrochloride rats also demonstrated an elevated production of the pro-inflammatory cytokines such as interleukin-1 and - 6, interferon-γ, and tumor necrosis factor-α) and reduced levels of an anti-inflammatory cytokine such as interleukin-10, a leading cause of the increase in arterial stiffness and risk of CVD.

Moreover, increased butyrylcholinesterase activity associated with chronic inflammation was also found in the Nω-nitro-L-arginine methyl ester hydrochloride rats.

However, all parameters caused by the injection of Nω-nitro-L-arginine methyl ester hydrochloride involved in the onset of hypertension were totally inhibited by the application of ginger (Zingiber officinale) and turmeric (Curcuma longa).


Based on the findings, researchers said, "these activities could suggest a possible insight about the protective mechanisms of the rhizomes against hypertension-related inflammation."


Taken altogether, turmeric used alone or in combination with ginger may be considered supplements for the prevention and treatment of hypertension, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary Supplementation of Ginger and Turmeric Rhizomes Modulates Platelets Ectonucleotidase and Adenosine Deaminase Activities in Normotensive and Hypertensive Rats by Akinyemi AJ1,2,3, Thomé GR3, Morsch VM3, Bottari NB3, Baldissarelli J3, de Oliveira LS3, Goularte JF4, Belló-Klein A4, Oboh G1, Schetinger MR. (PubMed)
(2) Effect of Ginger and Turmeric Rhizomes on Inflammatory Cytokines Levels and Enzyme Activities of Cholinergic and Purinergic Systems in Hypertensive Rats by Akinyemi AJ1, Thomé GR2, Morsch VM2, Bottari NB2, Baldissarelli J2, de Oliveira LS2, Goularte JF3, Belló-Klein A3, Duarte T4, Duarte M4, Boligon AA5, Athayde ML5, Akindahunsi AA1, Oboh G1, Schetinger MR. (PubMed)
(3) The effect of nutrition on blood pressure by Savica V1, Bellinghieri G, Kopple JD(PubMed)

Cruciferous vegetables Inhibit Oral Cancer in Vitro

By Kyle J. Norton

Oral cancer is a medical condition characterized by irregular cell growth in the oral cavity. In the early stage, the abnormal cells only appear in the surface lining of the cavity. However, in the late stage, the infectious cells may travel a distance away from the original site to invade other cells and tissue.

Early diagnosed oral cancer may have a close to 100% recovery.

Most cases of oral cancer begin in the cells on the surface of the inner lining of oral tissue.

However, at the advanced stage, oral cancer cells can travel a distance away to infect other healthy tissue and organs, leading to secondary metastasis.

According to the statistic provided by the American Cancer Society, in 2018, approximately 51,540 people were diagnosed with oral cavity or oropharyngeal cancer. The disease causes the death of an estimated 10,030 people.

The 5-year survival rate of oral cancer is 66%, including all stages.

Family history, smoking, alcohol drinking, infection by the HPV virus, poor hygiene, and genetic preposition are some of the risk factors associated with the disease.

According to the cancer society, the 5 survival rate of oral cancer is about 60% plus without taking into consideration the stage of cancer.

The early symptoms of oral cancer include lip or mouth sores and persistent pain,... Check with a dentist, if you experience the above unexplained or persistent symptoms, particularly, if the sore mouth does not heal in 2 weeks.

Cruciferous vegetables are a group of vegetables, belongings of the family Brassicaceae (also called Cruciferae) with many genera, species, and cultivated all over the world in suitable climates for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.

On finding potential and natural foods for the prevention and treatment of cancer, researchers investigated the effect of sulforaphane, a predominant isothiocyanate in Brassica oleracea, a family of cruciferous vegetables on oral carcinoma cell lines.

According to the tested analysis. sulforaphane showed strong growth inhibition of oral carcinoma cell lines by blocking the cancer cell migration and invasion activities.

Based on the Multiplex protein analysis kits, the impairment of the migration and invasion induced by sulforaphane were attributed to associated with the anti-orchestration in the secretion of metalloprotease levels including MMP-1 and MMP-2.

In other words, sulforaphane demonstrated a therapeutic potency as an inhibitor of metastasis in oral carcinoma cell lines.

Taken altogether, cruciferous vegetables processed abundantly sulforaphane, may be considered functional remedies for the prevention of oral cancer, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sulforaphane inhibits oral carcinoma cell migration and invasion in vitro by Jee HG1, Lee KE, Kim JB, Shin HK, Youn YK. (PubMed)

Phytochemical Beta-Sitosterol Alleviates the Progression of Fatty Liver in Vivo

By Kyle J. Norton

The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing them to other parts of the body.

The liver also produces cholesterol, a waxy substance that aids digestion, builds cell membranes, and produces vitamin D and steroid hormones.

Liver disease is a class of medical conditions characterized by reducing partly or completely the function of the liver, including liver failure.

A fatty liver is a liver condition associated with the accumulation of excess fat in the liver.

There are two main types of fatty liver disease:
* Nonalcoholic fatty liver disease is a medical condition characterized by fat accumulated in the liver tissue other than excessive consumption of alcohol.
According to the American liver foundation, Nonalcoholic Fatty Liver Disease is one of the most common causes of liver disease, and approximately 30% (100 million) individuals in the United States are estimated to have nonalcoholic fatty liver disease.

The causes of Nonalcoholic Fatty Liver Disease are unknown. Also, as of today researchers do not understand why some people are susceptible to liver fat accumulation while others are not.

The disease can be classified into the types of non-inflammatory fatty liver (NAFL) and inflammatory nonalcoholic steatohepatitis (NASH) and acute fatty liver of pregnancy (AFLP), a relatively rare disorder that happens only during pregnancy.

* Alcoholic fatty liver diseases is a condition caused by lifelong heavy alcohol use.

In other words, substances found in alcohol damage liver cells, promote inflammation and weaken your body's natural defenses. More precisely, the more alcohol that you drink, the more you damage your liver.

Alcoholic fatty liver disease is the earliest stage of alcohol-related liver disease.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

In finding a potential phytochemical for the prevention and treatment of liver diseases, researchers elucidated the effects of stigmasterol and β-sitosterol on a high-fat Western diet (HFWD)-induced nonalcoholic fatty liver disease (NAFLD).

According to the results after 33 weeks of treatment* stigmasterol and β-sitosterol were effective in protecting the liver against HFWD-induced NAFLD.

* The parameters that contributed to the onset of NAFLD are triacylglycerols (TGs), phosphatidylcholines, cholesteryl esters, diacylglycerols, and free fatty acids (FFAs).

* The efficacy of stigmasterol and β-sitosterol in the alleviation of NAFLD was mainly associated with decreases in hepatic cholesterol, TGs with polyunsaturated fatty acids, and alterations of free hepatic FFA.

Based on the findings, researchers said, "phytosterols, at a dose comparable to that suggested for humans by the FDA for the reduction of plasma cholesterol levels, are shown to protect against NAFLD in this long-term (33-week) study".

Beta-Sitosterol may be considered a remedy for the prevention and treatment of NAFLD, pending the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of Stigmasterol and β-Sitosterol on Nonalcoholic Fatty Liver Disease in a Mouse Model: A Lipidomic Analysis by Feng S1,2,3, Gan L1, Yang CS2, Liu AB2, Lu W4, Shao P1, Dai Z5, Sun P1, Luo Z. (PubMed)

Fermented Soy Shows Lowering Blood Cholesterol Property, Clinical Diagnosis Suggests

By Kyle J. Norton

Cholesterol is a waxy substance that is produced either by the liver or injected from animal food sources.

Cholesterol found in our body is needed for our body to build cell walls, hormones, and vitamin D, and create bile salts that aid digestion. However, too much of them, in most cases due to the intake of animal protein can cause plaques to build up on the arterial wall, the major cause of heart disease and stroke.

More precisely, if levels of low-density lipoprotein are high compared to high-density lipoprotein which returns the accessed cholesterol back to the liver, you have high blood cholesterol.

In other words, healthy blood cholesterol is any level with either less than or equal to 4 (low-density lipoprotein/ 1 (high-density lipoprotein).

The most common diseases associated with high cholesterol are cardiovascular disease, including coronary heart disease, stroke, and peripheral vascular disease.

Most patients with high cholesterol also have diabetes and high blood pressure.

Hyperlipidemia is a condition of abnormally high levels of cholesterol in the bloodstream.

High blood cholesterol is the most common cause of hyperlipidemia.

According to statistics provided by the CDC, more than 12% of adults age 20 and older are living with high blood cholesterol with a total cholesterol higher than 240 mg/dL. and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL.

In other words, hyperlipidemia has a high prevalent ratio that affects over 100 million Americans and the condition is increasing at an alarming rate due to overweight and obesity.

Believe it or not, only half of the people with high blood cholesterol benefits from taking the lowering blood cholesterol medicine.

Fermented soy products are diverse varieties of soy food that are made from fermented soybeans, including miso, natto, tempeh, and soy sauce.

On finding a potential plant that processes high blood cholesterol activity researchers examined the health benefits of QCAN® Plus-an easily available fermented soy drink.

According to the results of the analysis of the study that was performed on lean (n = 10) and obese (n = 10) subjects during pre-soy (weeks -2, -1, and 0), on-soy (weeks 1, 2, 3, and 4), and post-soy (weeks 6, 8, 10, and 12) periods,* Total cholesterol and low-density lipoprotein (LDL) cholesterol levels were significantly reduced in both lean and obese individuals during on-soy (P ≤ .05).

* Furthermore, cytokines such as platelet-derived growth factor (PDGF) AA and AB/BB were significantly lowered on-soy compared with pre-soy (P ≤ .05) in lean subjects, and PDGF AA, IL-1RA, and GMCSF were significantly reduced on-soy (P ≤ .05) in obese subjects.

* The product is safe.

In other words, QCAN® Plus-an easily available fermented soy drink. showed a strong effect on the inhibition of high blood cholesterol and lipid oxidation.

Collectively, researchers said, "Our preliminary study on Q-CAN Plus ensures its safety for consumption and highlights its hypolipidemic and suppressive effect on certain cytokines ".

Taken altogether, fermented soy may be considered a functional food for the prevention and treatment of high blood cholesterol, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Fermented Soy Beverage Q-CAN Plus Consumption Improves Serum Cholesterol and Cytokines by Arumugam S1, Dioletis E1, Paiva R1, Fields MR2, Weiss TR2, Secor ER3, Ali A, (PubMed)